Publications by authors named "Yoel Sadovsky"

100Publications

Transgenic expression of human C19MC miRNAs impacts placental morphogenesis.

Placenta 2020 Sep 29;101:208-214. Epub 2020 Sep 29.

Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.placenta.2020.09.069DOI Listing
September 2020

Internalization of trophoblastic small extracellular vesicles and detection of their miRNA cargo in P-bodies.

J Extracell Vesicles 2020 Aug 28;9(1):1812261. Epub 2020 Aug 28.

Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1080/20013078.2020.1812261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480505PMC
August 2020

Trophoblastic extracellular vesicles and viruses: Friends or foes?

Am J Reprod Immunol 2020 Sep 16:e13345. Epub 2020 Sep 16.

Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1111/aji.13345DOI Listing
September 2020

Optimal timing of antenatal corticosteroid administration and preterm neonatal and early childhood outcomes.

Am J Obstet Gynecol MFM 2020 Feb 17;2(1). Epub 2019 Dec 17.

Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of North Carolina-Chapel Hill, Chapel Hill, NC.

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http://dx.doi.org/10.1016/j.ajogmf.2019.100077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469940PMC
February 2020

Correction: Separating extracellular vesicles and lipoproteins via acoustofluidics.

Lab Chip 2020 09 19;20(18):3472. Epub 2020 Aug 19.

Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27707, USA.

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http://dx.doi.org/10.1039/d0lc90093aDOI Listing
September 2020

Reply to "Diversity is essential for good science and Reproductive science is no different: A response to the recent formulation of the Burroughs Welcome Fund Pregnancy Think-Tank".

Am J Obstet Gynecol 2020 Aug 11. Epub 2020 Aug 11.

Office of the President, Burroughs Wellcome Fund, 21 TW Alexander Dr., Research Triangle Park, NC 27709. Electronic address:

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http://dx.doi.org/10.1016/j.ajog.2020.08.009DOI Listing
August 2020

Increasing NIH funding for academic departments of obstetrics and gynecology: a call to action.

Am J Obstet Gynecol 2020 07 6;223(1):79.e1-79.e8. Epub 2020 Apr 6.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1016/j.ajog.2020.03.022DOI Listing
July 2020

Unique microRNA Signals in Plasma Exosomes from Pregnancies Complicated by Preeclampsia.

Hypertension 2020 Mar 27;75(3):762-771. Epub 2020 Jan 27.

From the Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute (H.L., Y.O., E.S., T.C., Y.S.), University of Pittsburgh, PA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.14081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076905PMC
March 2020

Deep phenotyping during pregnancy for predictive and preventive medicine.

Sci Transl Med 2020 01;12(527)

Magee-Womens Research Institute and Departments of OBGYN and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1126/scitranslmed.aay1059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268934PMC
January 2020

Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia.

Autophagy 2020 Oct 26;16(10):1771-1785. Epub 2019 Dec 26.

Departments of Pediatrics, Obstetrics and Gynecology and Pathology, Women and Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University , Providence, RI, USA.

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http://dx.doi.org/10.1080/15548627.2019.1707494DOI Listing
October 2020

Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors.

Cell Death Dis 2019 12 5;10(12):927. Epub 2019 Dec 5.

Departments of Pediatrics, Obstetrics and Gynecology and Pathology, Women and Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University, Providence, RI, USA.

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http://dx.doi.org/10.1038/s41419-019-2162-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895177PMC
December 2019

Klf14 is an imprinted transcription factor that regulates placental growth.

Placenta 2019 12 27;88:61-67. Epub 2019 Sep 27.

Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, USA. Electronic address:

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http://dx.doi.org/10.1016/j.placenta.2019.09.013DOI Listing
December 2019

The biology of extracellular vesicles: The known unknowns.

PLoS Biol 2019 07 18;17(7):e3000363. Epub 2019 Jul 18.

Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.3000363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667152PMC
July 2019

Separating extracellular vesicles and lipoproteins via acoustofluidics.

Lab Chip 2019 03;19(7):1174-1182

Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27707, USA.

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http://dx.doi.org/10.1039/c8lc01134fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453118PMC
March 2019

Distinct communication patterns of trophoblastic miRNA among the maternal-placental-fetal compartments.

Placenta 2018 12 22;72-73:28-35. Epub 2018 Oct 22.

Magee-Womens Research Institute, USA; Department of Obstetrics and Gynecology and Reproductive Science, University of Pittsburgh, Pittsburgh, PA, 15213, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Electronic address:

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http://dx.doi.org/10.1016/j.placenta.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329371PMC
December 2018

PLIN2 Is Essential for Trophoblastic Lipid Droplet Accumulation and Cell Survival During Hypoxia.

Endocrinology 2018 12;159(12):3937-3949

Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1210/en.2018-00752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240902PMC
December 2018

Human Placental Syncytiotrophoblasts Restrict Attachment and Replication and Respond to Infection by Producing Immunomodulatory Chemokines.

mBio 2018 01 9;9(1). Epub 2018 Jan 9.

Department of Biological Sciences, Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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http://dx.doi.org/10.1128/mBio.01678-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760739PMC
January 2018

Chromosome 19 microRNAs exert antiviral activity independent from type III interferon signaling.

Placenta 2018 01 10;61:33-38. Epub 2017 Nov 10.

Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Obstetrics and Gynecology, and Reproductive Science, University of Pittsburgh, PA 15213, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address:

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http://dx.doi.org/10.1016/j.placenta.2017.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745809PMC
January 2018

Research to knowledge: promoting the training of physician-scientists in the biology of pregnancy.

Am J Obstet Gynecol 2018 01 7;218(1):B9-B13. Epub 2017 Oct 7.

Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina, USA.

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http://dx.doi.org/10.1016/j.ajog.2017.09.024DOI Listing
January 2018

Isolation of exosomes from whole blood by integrating acoustics and microfluidics.

Proc Natl Acad Sci U S A 2017 10 18;114(40):10584-10589. Epub 2017 Sep 18.

Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708;

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http://dx.doi.org/10.1073/pnas.1709210114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635903PMC
October 2017

Organotypic models of type III interferon-mediated protection from Zika virus infections at the maternal-fetal interface.

Proc Natl Acad Sci U S A 2017 08 7;114(35):9433-9438. Epub 2017 Aug 7.

Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213;

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http://dx.doi.org/10.1073/pnas.1707513114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584447PMC
August 2017

Microbial Vertical Transmission during Human Pregnancy.

Cell Host Microbe 2017 May;21(5):561-567

Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA; Center for Microbial Pathogenesis, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2017.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148370PMC
May 2017

The expression level of C19MC miRNAs in early pregnancy and in response to viral infection.

Placenta 2017 05 16;53:23-29. Epub 2017 Mar 16.

Magee-Womens Research Institute, Pittsburgh, PA, United States; Department of OBGYN and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, United States; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.placenta.2017.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506831PMC
May 2017

Development and Testing of the MyHealthyPregnancy App: A Behavioral Decision Research-Based Tool for Assessing and Communicating Pregnancy Risk.

JMIR Mhealth Uhealth 2017 Apr 10;5(4):e42. Epub 2017 Apr 10.

Magee-Womens Research Institute, Department of OBGYN and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, United States.

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http://dx.doi.org/10.2196/mhealth.7036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404142PMC
April 2017

Formation and size distribution of self-assembled vesicles.

Proc Natl Acad Sci U S A 2017 03 6;114(11):2910-2915. Epub 2017 Mar 6.

Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1702065114
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http://dx.doi.org/10.1073/pnas.1702065114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358381PMC
March 2017

The function of miR-519d in cell migration, invasion, and proliferation suggests a role in early placentation.

Placenta 2016 12 10;48:34-37. Epub 2016 Oct 10.

Magee-Womens Research Institute, Department of OBGYN and Reproductive Sciences, University of Pittsburgh, PA 15213, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01434004163054
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http://dx.doi.org/10.1016/j.placenta.2016.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130096PMC
December 2016

Isolation of human trophoblastic extracellular vesicles and characterization of their cargo and antiviral activity.

Placenta 2016 11 14;47:86-95. Epub 2016 Sep 14.

Magee-Womens Research Institute, Department of OBGYN and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address:

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http://dx.doi.org/10.1016/j.placenta.2016.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123854PMC
November 2016

Intact feto-placental growth in microRNA-210 deficient mice.

Placenta 2016 11 23;47:113-115. Epub 2016 Sep 23.

Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.placenta.2016.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123836PMC
November 2016

Determinants of effective lentivirus-driven microRNA expression in vivo.

Sci Rep 2016 09 15;6:33345. Epub 2016 Sep 15.

Magee-Womens Research Institute, Department of Obstetrics, Gynaecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213 USA.

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http://dx.doi.org/10.1038/srep33345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024309PMC
September 2016

Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection.

Cell Host Microbe 2016 May 5;19(5):705-12. Epub 2016 Apr 5.

Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Obstetrics, Gynecology, and Reproductive Science, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19313128163010
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http://dx.doi.org/10.1016/j.chom.2016.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866896PMC
May 2016

Comparison of syncytiotrophoblast generated from human embryonic stem cells and from term placentas.

Proc Natl Acad Sci U S A 2016 May 5;113(19):E2598-607. Epub 2016 Apr 5.

Division of Animal Sciences, Bond Life Sciences Center, University of Missouri, Columbia, MO 65211; Department of Biochemistry, University of Missouri, Columbia, MO 65211

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http://dx.doi.org/10.1073/pnas.1601630113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868474PMC
May 2016

Isolation of basal membrane proteins from BeWo cells and their expression in placentas from fetal growth-restricted pregnancies.

Placenta 2016 Mar 6;39:24-32. Epub 2016 Jan 6.

Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.placenta.2016.01.001DOI Listing
March 2016

A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance.

Sci Adv 2016 Mar 4;2(3):e1501462. Epub 2016 Mar 4.

Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA.; Magee-Womens Research Institute, Department of Obstetrics, Gynecology, and Reproductive Science, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://advances.sciencemag.org/cgi/doi/10.1126/sciadv.150146
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http://dx.doi.org/10.1126/sciadv.1501462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783126PMC
March 2016

Predictors of response to 17-alpha hydroxyprogesterone caproate for prevention of recurrent spontaneous preterm birth.

Am J Obstet Gynecol 2016 Mar 12;214(3):376.e1-8. Epub 2015 Dec 12.

Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.

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http://dx.doi.org/10.1016/j.ajog.2015.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803498PMC
March 2016

MicroRNAs in placental health and disease.

Am J Obstet Gynecol 2015 Oct;213(4 Suppl):S163-72

Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA. Electronic address:

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http://dx.doi.org/10.1016/j.ajog.2015.05.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592520PMC
October 2015

The expression and post-transcriptional regulation of FSTL1 transcripts in placental trophoblasts.

Placenta 2015 Nov 10;36(11):1231-8. Epub 2015 Sep 10.

Magee-Womens Research Institute, University of Pittsburgh, PA, USA; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, PA, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.placenta.2015.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644452PMC
November 2015

ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry.

PLoS Pathog 2015 Sep 15;11(9):e1005150. Epub 2015 Sep 15.

Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Magee-Womens Research Institute, Department of Obstetrics, Gynecology, and Reproductive Science, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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http://search.proquest.com/openview/1b90cce4fca1aec783369988
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http://dx.plos.org/10.1371/journal.ppat.1005150
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http://dx.doi.org/10.1371/journal.ppat.1005150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570769PMC
September 2015

Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms.

Am J Obstet Gynecol 2015 Sep 9;213(3):429.e1-9. Epub 2015 Jun 9.

Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.

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http://dx.doi.org/10.1016/j.ajog.2015.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556543PMC
September 2015

Perinatal outcomes and unconventional natural gas operations in Southwest Pennsylvania.

PLoS One 2015 3;10(6):e0126425. Epub 2015 Jun 3.

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126425PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454655PMC
February 2016

The Function of TrophomiRs and Other MicroRNAs in the Human Placenta.

Cold Spring Harb Perspect Med 2015 Apr 15;5(8):a023036. Epub 2015 Apr 15.

Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15219.

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http://dx.doi.org/10.1101/cshperspect.a023036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526727PMC
April 2015

The phenotype of spontaneous preterm birth: application of a clinical phenotyping tool.

Am J Obstet Gynecol 2015 Apr 14;212(4):487.e1-487.e11. Epub 2015 Feb 14.

Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.

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https://linkinghub.elsevier.com/retrieve/pii/S00029378150013
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http://dx.doi.org/10.1016/j.ajog.2015.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456184PMC
April 2015

The assembly of miRNA-mRNA-protein regulatory networks using high-throughput expression data.

Bioinformatics 2015 Jun 24;31(11):1780-7. Epub 2015 Jan 24.

Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, 15213 USA, Women's Health Integrated Research Center at Inova Health System, Annandale, VA, 22003 USA and Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, 15213 USA Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, 15213 USA, Women's Health Integrated Research Center at Inova Health System, Annandale, VA, 22003 USA and Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, 15213 USA.

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http://dx.doi.org/10.1093/bioinformatics/btv038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443676PMC
June 2015

A genome-wide association study of early spontaneous preterm delivery.

Genet Epidemiol 2015 Mar 19;39(3):217-26. Epub 2015 Jan 19.

Department of Biostatistics, Yale University School of Public Health, New Haven, Connecticut, United States of America.

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http://dx.doi.org/10.1002/gepi.21887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366311PMC
March 2015

Prevention of preterm birth: harnessing science to address the global epidemic.

Sci Transl Med 2014 Nov;6(262):262sr5

Global Alliance to Prevent Prematurity and Stillbirth, Seattle Children's Hospital, Seattle, WA 98101, USA.

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http://dx.doi.org/10.1126/scitranslmed.3009871DOI Listing
November 2014

The Placenta as a Barrier to Viral Infections.

Annu Rev Virol 2014 Nov;1(1):133-46

Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15219; email:

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http://dx.doi.org/10.1146/annurev-virology-031413-085524DOI Listing
November 2014

C19MC microRNAs regulate the migration of human trophoblasts.

Endocrinology 2014 Dec 11;155(12):4975-85. Epub 2014 Sep 11.

Magee-Womens Research Institute (L.X., J.-F.M., T.C., W.T.P., E.S., Y.S.), Department of OBGYN and Reproductive Sciences, University of Pittsburgh, Pennsylvania 15213; Medical Systems Biology Research Center (L.X.), Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing 100084 China; Department of Obstetrics and Fetal-Maternal Medicine (M.K.), Reproductive Biology Unit, Medical University of Vienna, Vienna, A-1090 Austria; and Department of Microbiology and Molecular Genetics (Y.S.), University of Pittsburgh, Pennsylvania 15213.

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http://dx.doi.org/10.1210/en.2014-1501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239420PMC
December 2014

Molecular speciation and dynamics of oxidized triacylglycerols in lipid droplets: Mass spectrometry and coarse-grained simulations.

Free Radic Biol Med 2014 Nov 10;76:53-60. Epub 2014 Aug 10.

Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA; Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2014.07.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276254PMC
November 2014

Human trophoblasts confer resistance to viruses implicated in perinatal infection.

Am J Obstet Gynecol 2015 Jan 6;212(1):71.e1-71.e8. Epub 2014 Aug 6.

Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1016/j.ajog.2014.07.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275367PMC
January 2015

The role of trophoblastic microRNAs in placental viral infection.

Int J Dev Biol 2014 ;58(2-4):281-9

Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1387/ijdb.130349ysDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377297PMC
March 2015

Maternal serum serpin B7 is associated with early spontaneous preterm birth.

Am J Obstet Gynecol 2014 Dec 19;211(6):678.e1-12. Epub 2014 Jun 19.

Center for Cancer Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1016/j.ajog.2014.06.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254341PMC
December 2014

Advancing research transdisciplinarity within our discipline.

Am J Obstet Gynecol 2014 Sep 11;211(3):205-7. Epub 2014 Feb 11.

Department of Obstetrics and Gynecology, Columbia University, New York, NY.

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http://dx.doi.org/10.1016/j.ajog.2014.02.006DOI Listing
September 2014

NDRG1 deficiency attenuates fetal growth and the intrauterine response to hypoxic injury.

Endocrinology 2014 Mar 1;155(3):1099-106. Epub 2013 Jan 1.

Magee-Womens Research Institute (J.L., X.H.S., T.M., Y.B., Y.S.), Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15213; Department of Obstetrics and Gynecology (B.C.), Washington University, St Louis, Missouri 63110; Department of Molecular Pathogenesis (K.K.), National Cerebral and Cardiovascular Center, Osaka, Japan 565-8565; and Department of Microbiology and Molecular Genetics (Y.B., Y.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15213.

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http://dx.doi.org/10.1210/en.2013-1425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929742PMC
March 2014

Autophagy as a mechanism of antiviral defense at the maternal-fetal interface.

Autophagy 2013 Dec 8;9(12):2173-4. Epub 2013 Oct 8.

Department of Microbiology and Molecular Genetics; University of Pittsburgh; Pittsburgh, PA USA.

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http://dx.doi.org/10.4161/auto.26558DOI Listing
December 2013

The expression and localization of N-myc downstream-regulated gene 1 in human trophoblasts.

PLoS One 2013 16;8(9):e75473. Epub 2013 Sep 16.

Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075473PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774633PMC
May 2014

Human placental trophoblasts confer viral resistance to recipient cells.

Proc Natl Acad Sci U S A 2013 Jul 1;110(29):12048-53. Epub 2013 Jul 1.

Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA.

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http://dx.doi.org/10.1073/pnas.1304718110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718097PMC
July 2013

The unique expression and function of miR-424 in human placental trophoblasts.

Biol Reprod 2013 Aug 1;89(2):25. Epub 2013 Aug 1.

Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1095/biolreprod.113.110049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076361PMC
August 2013

Homeobox gene transforming growth factor β-induced factor-1 (TGIF-1) is a regulator of villous trophoblast differentiation and its expression is increased in human idiopathic fetal growth restriction.

Mol Hum Reprod 2013 Oct 11;19(10):665-75. Epub 2013 Jun 11.

Department of Perinatal Medicine Pregnancy Research Centre, and University of Melbourne Department of Obstetrics and Gynaecology, Royal Women's Hospital, Locked Bag 300, Parkville, VIC 3052, Australia.

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http://dx.doi.org/10.1093/molehr/gat042DOI Listing
October 2013

Lipid raft- and SRC family kinase-dependent entry of coxsackievirus B into human placental trophoblasts.

J Virol 2013 Aug 29;87(15):8569-81. Epub 2013 May 29.

Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1128/JVI.00708-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719791PMC
August 2013

Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.

Dev Biol 2012 Dec 29;372(1):143-55. Epub 2012 Aug 29.

Magee-Womens Research Institute, Department of OBGYN and Reproductive Sciences, University of Pittsburgh, 204 Craft Avenue, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1016/j.ydbio.2012.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479343PMC
December 2012

The expression profile of C19MC microRNAs in primary human trophoblast cells and exosomes.

Mol Hum Reprod 2012 Aug 29;18(8):417-24. Epub 2012 Feb 29.

Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh, 204 Craft Avenue, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1093/molehr/gas013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389496PMC
August 2012

The expression and function of fatty acid transport protein-2 and -4 in the murine placenta.

PLoS One 2011 20;6(10):e25865. Epub 2011 Oct 20.

Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197585PMC
February 2012

Fatty acid binding protein 4 regulates intracellular lipid accumulation in human trophoblasts.

J Clin Endocrinol Metab 2011 Jul 27;96(7):E1083-91. Epub 2011 Apr 27.

Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1210/jc.2010-2084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135200PMC
July 2011

Expression patterns of placental microRNAs.

Birth Defects Res A Clin Mol Teratol 2011 Aug 21;91(8):737-43. Epub 2011 Mar 21.

Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh, 204 Craft Avenue, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1002/bdra.20782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030720PMC
August 2011

Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.

Am J Physiol Cell Physiol 2010 Nov 1;299(5):C968-76. Epub 2010 Sep 1.

Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://ajpcell.physiology.org/cgi/doi/10.1152/ajpcell.00154.
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http://dx.doi.org/10.1152/ajpcell.00154.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980304PMC
November 2010

Administration of steroids after 34 weeks of gestation enhances fetal lung maturity profiles.

Am J Obstet Gynecol 2010 Jul 15;203(1):47.e1-5. Epub 2010 May 15.

Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, MO, USA.

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http://dx.doi.org/10.1016/j.ajog.2010.02.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655550PMC
July 2010

Basic and clinical studies on functional RNA molecules for advanced medical technologies.

J Nippon Med Sch 2010 Apr;77(2):71-9

Division of Molecular Medicine and Anatomy, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

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April 2010

MiR-205 silences MED1 in hypoxic primary human trophoblasts.

FASEB J 2010 Jun 11;24(6):2030-9. Epub 2010 Jan 11.

Magee-Womens Research Institute, Department of Obstetrics, Gynecology, and Reproductive Sciences, Pittsburgh, PA 15213, USA.

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http://www.fasebj.org/cgi/doi/10.1096/fj.09-149724
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http://dx.doi.org/10.1096/fj.09-149724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874470PMC
June 2010

Magnetic resonance imaging of hypoxic injury to the murine placenta.

Am J Physiol Regul Integr Comp Physiol 2010 Feb 18;298(2):R312-9. Epub 2009 Nov 18.

Department of Obstetrics and Gynecology, Washington University, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1152/ajpregu.00425.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828172PMC
February 2010

Hypoxia in human trophoblasts stimulates the expression and secretion of connective tissue growth factor.

Endocrinology 2008 Jun 21;149(6):2952-8. Epub 2008 Feb 21.

Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1210/en.2007-1099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408813PMC
June 2008

PPAR Signaling in Placental Development and Function.

PPAR Res 2008 ;2008:142082

The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225458PMC
July 2011

Epidermal growth factor abrogates hypoxia-induced apoptosis in cultured human trophoblasts through phosphorylation of BAD Serine 112.

Endocrinology 2008 May 14;149(5):2131-7. Epub 2008 Feb 14.

Department of Obstetrics-Gynecology, Washington University School of Medicine, 4566 Scott Avenue, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1210/en.2007-1253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2329276PMC
May 2008

DEAD-box protein-103 (DP103, Ddx20) is essential for early embryonic development and modulates ovarian morphology and function.

Endocrinology 2008 May 7;149(5):2168-75. Epub 2008 Feb 7.

Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1210/en.2007-1237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2329271PMC
May 2008

Hypoxia regulates the expression of fatty acid-binding proteins in primary term human trophoblasts.

Am J Obstet Gynecol 2007 Nov 10;197(5):516.e1-6. Epub 2007 Sep 10.

Department of Obstetrics and Gynecology, Washington University in St Louis School of Medicine, St Louis, MO, USA.

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http://dx.doi.org/10.1016/j.ajog.2007.03.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151846PMC
November 2007

Ligand-activated peroxisome proliferator activated receptor gamma alters placental morphology and placental fatty acid uptake in mice.

Endocrinology 2007 Aug 26;148(8):3625-34. Epub 2007 Apr 26.

Washington University School of Medicine, Department of Obstetrics and Gynecology, Campus Box 8064, 4566 Scott Avenue, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1210/en.2007-0211DOI Listing
August 2007

The expression of Argonaute2 and related microRNA biogenesis proteins in normal and hypoxic trophoblasts.

Mol Hum Reprod 2007 Apr 27;13(4):273-9. Epub 2007 Feb 27.

Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1093/molehr/gam006DOI Listing
April 2007

Fetal heart rate accelerations and the risk of cerebral lesions and poor neurodevelopmental outcome in very low birthweight neonates.

Am J Perinatol 2007 Feb 29;24(2):83-8. Epub 2007 Jan 29.

Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-2006-958161
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http://dx.doi.org/10.1055/s-2006-958161DOI Listing
February 2007

Increased expression of N-myc downstream-regulated gene 1 (NDRG1) in placentas from pregnancies complicated by intrauterine growth restriction or preeclampsia.

Am J Obstet Gynecol 2007 Jan;196(1):45.e1-7

Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1016/j.ajog.2006.08.029DOI Listing
January 2007

The use of needle biopsy for assessment of placental gene expression.

Am J Obstet Gynecol 2006 Apr;194(4):1137-42; discussion 1142-4

Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO, USA.

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http://dx.doi.org/10.1016/j.ajog.2005.12.021DOI Listing
April 2006

The pleiotropic function of PPAR gamma in the placenta.

Mol Cell Endocrinol 2006 Apr 29;249(1-2):10-5. Epub 2006 Mar 29.

Department of Obstetrics and Gynecology, and Cell Biology and Physiology, Washington University School of Medicine, Department of OBGYN - Campus Box 8064, 4566 Scott Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.mce.2006.02.009DOI Listing
April 2006

The rare occurrence of absent adrenals in a term infant: a case report and review of the literature.

Am J Perinatol 2006 Feb;23(2):111-4

Department of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1055/s-2006-931911DOI Listing
February 2006

N-myc down-regulated gene 1 modulates the response of term human trophoblasts to hypoxic injury.

J Biol Chem 2006 Feb 28;281(5):2764-72. Epub 2005 Nov 28.

Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M507330200DOI Listing
February 2006

Insulin and fatty acids regulate the expression of the fat droplet-associated protein adipophilin in primary human trophoblasts.

Am J Obstet Gynecol 2005 Nov;193(5):1716-23

Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1016/j.ajog.2005.04.012DOI Listing
November 2005

The mean weekly increment of amniotic fluid TDx-FLM II ratio is constant during the latter part of pregnancy.

Am J Obstet Gynecol 2005 Nov;193(5):1685-90

Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO, USA.

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http://dx.doi.org/10.1016/j.ajog.2005.03.070DOI Listing
November 2005

Microarray analysis of trophoblast cells.

Methods Mol Med 2006 ;121:411-24

Department of Obstetrics & Gynecology, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1385/1-59259-983-4:409DOI Listing
December 2005

Tumor heterogeneity affects the precision of microarray analysis.

Diagn Mol Pathol 2005 Jun;14(2):65-71

Department of Pathology, University of British Columbia, British Columbia's Children's Hospital, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1097/01.pas.0000158988.46025.f6DOI Listing
June 2005

Peroxisome proliferator-activated receptor-gamma and retinoid X receptor signaling regulate fatty acid uptake by primary human placental trophoblasts.

J Clin Endocrinol Metab 2005 Jul 12;90(7):4267-75. Epub 2005 Apr 12.

Washington University School of Medicine, Department of Obstetrics and Gynecology, Campus Box 8064, 4566 Scott Avenue, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1210/jc.2004-2265DOI Listing
July 2005