Yixin Zeng

Yixin Zeng

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Yixin Zeng

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The novel non-immunological role and underlying mechanisms of B7-H3 in tumorigenesis.

J Cell Physiol 2019 Dec 21;234(12):21785-21795. Epub 2019 Jun 21.

Department of Radiotherapy of the First Affiliated Hospital, University of South China, Hengyang, China.

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http://dx.doi.org/10.1002/jcp.28936DOI Listing
December 2019

The c-Myc-regulated miR-17-92 cluster mediates ATRA-induced APL cell differentiation.

Asia Pac J Clin Oncol 2019 Dec 1;15(6):364-370. Epub 2019 Jul 1.

Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory Oncology in South China, Guangzhou, China.

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http://dx.doi.org/10.1111/ajco.13225DOI Listing
December 2019

Analysis of 47 non-MHC Ankylosing Spondylitis Susceptibility Loci Reveals Shared Associated Variants across Caucasians and Han Chinese.

J Rheumatol 2019 Sep 15. Epub 2019 Sep 15.

From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email:

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http://dx.doi.org/10.3899/jrheum.190184DOI Listing
September 2019

Immunization With Fc-Based Recombinant Epstein-Barr Virus gp350 Elicits Potent Neutralizing Humoral Immune Response in a BALB/c Mice Model.

Front Immunol 2018 1;9:932. Epub 2018 May 1.

Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, China.

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http://dx.doi.org/10.3389/fimmu.2018.00932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938345PMC
July 2019

Outcome of chemotherapy with or without targeted agents in metastatic colorectal cancer patients with deficient DNA mismatch repair: A single center, cohort study.

Asia Pac J Clin Oncol 2019 Jun 29;15(3):128-135. Epub 2019 Jan 29.

Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1111/ajco.13130DOI Listing
June 2019

Changes in Expression of Multiple Checkpoint Molecules and Infiltration of Tumor Immune Cells after Neoadjuvant Chemotherapy in Gastric Cancer.

J Cancer 2019 2;10(12):2754-2763. Epub 2019 Jun 2.

State Key Laboratory of Molecular Oncology, National Cancer Center /National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.7150/jca.31755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584940PMC
June 2019

Successful treatment with pazopanib plus PD-1 inhibitor and RAK cells for advanced primary hepatic angiosarcoma: a case report.

BMC Cancer 2018 02 21;18(1):212. Epub 2018 Feb 21.

Department of Geriatric, Beijing Hospital, National Center of Gerontology, Beijing, 100730, People's Republic of China.

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http://dx.doi.org/10.1186/s12885-018-3996-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822655PMC
February 2018

Nasopharyngeal carcinoma super-enhancer-driven ETV6 correlates with prognosis.

Proc Natl Acad Sci U S A 2017 09 22;114(36):9683-9688. Epub 2017 Aug 22.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1705236114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594663PMC
September 2017

Estimation of heritability for nine common cancers using data from genome-wide association studies in Chinese population.

Int J Cancer 2017 Jan 11;140(2):329-336. Epub 2016 Oct 11.

Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China.

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http://dx.doi.org/10.1002/ijc.30447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536238PMC
January 2017

In vitro thermosensitivity of rat lateral parabrachial neurons.

Neurosci Lett 2016 Apr 2;619:15-20. Epub 2016 Mar 2.

Department of Physiology, Chengdu Medical College, Chengdu, Sichuan 610500, PR China; Key Laboratory of Thermoregulation and Inflammation of Sichuan Higher Education Institutes, Chengdu Medical College, Chengdu, Sichuan 610500, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2016.02.058DOI Listing
April 2016

Comprehensive profiling of EBV gene expression in nasopharyngeal carcinoma through paired-end transcriptome sequencing.

Front Med 2016 Mar 11;10(1):61-75. Epub 2016 Mar 11.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.

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http://link.springer.com/content/pdf/10.1007%2Fs11684-016-04
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http://link.springer.com/10.1007/s11684-016-0436-0
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http://dx.doi.org/10.1007/s11684-016-0436-0DOI Listing
March 2016

Common variations in TERT-CLPTM1L locus are reproducibly associated with the risk of nasopharyngeal carcinoma in Chinese populations.

Oncotarget 2016 Jan;7(1):759-70

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China.

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http://dx.doi.org/10.18632/oncotarget.6397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808031PMC
January 2016

TERT Polymorphism rs2736100-C Is Associated with EGFR Mutation-Positive Non-Small Cell Lung Cancer.

Clin Cancer Res 2015 Nov 6;21(22):5173-5180. Epub 2015 Jul 6.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-0009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644673PMC
November 2015

BIRC6-ALK, a Novel Fusion Gene in ALK Break-Apart FISH-Negative Lung Adenocarcinoma, Responds to Crizotinib.

J Thorac Oncol 2015 Jun;10(6):e37-9

Departments of *Pathology, †Medical Oncology, ‡Diagnostic Imaging, §Laboratory of Cell and Molecular Biology and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; ‖MyGenostics Inc., Baltimore, MD, USA; ¶Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College; #Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, China; and **State Key Laboratory of Oncology in Southern China, Guangzhou, China.

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http://dx.doi.org/10.1097/JTO.0000000000000467DOI Listing
June 2015

Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells.

Front Med 2015 Mar 7;9(1):57-62. Epub 2015 Feb 7.

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.

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http://link.springer.com/content/pdf/10.1007%2Fs11684-015-03
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http://link.springer.com/10.1007/s11684-015-0389-8
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http://dx.doi.org/10.1007/s11684-015-0389-8DOI Listing
March 2015

Exome sequencing reveals novel mutation targets in diffuse large B-cell lymphomas derived from Chinese patients.

Blood 2014 Oct 29;124(16):2544-53. Epub 2014 Aug 29.

Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, Sweden; Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, and Collaborative Innovation Center of Cancer Medicine, Guangzhou, China; and Guangzhou Institute of Respiratory Disease and China State Key Laboratory of Respiratory Disease, Guangzhou, China.

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http://dx.doi.org/10.1182/blood-2013-12-546309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199956PMC
October 2014

Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.

Authors:
Chen Wu Zhaoming Wang Xin Song Xiao-Shan Feng Christian C Abnet Jie He Nan Hu Xian-Bo Zuo Wen Tan Qimin Zhan Zhibin Hu Zhonghu He Weihua Jia Yifeng Zhou Kai Yu Xiao-Ou Shu Jian-Min Yuan Wei Zheng Xue-Ke Zhao She-Gan Gao Zhi-Qing Yuan Fu-You Zhou Zong-Min Fan Ji-Li Cui Hong-Li Lin Xue-Na Han Bei Li Xi Chen Sanford M Dawsey Linda Liao Maxwell P Lee Ti Ding You-Lin Qiao Zhihua Liu Yu Liu Dianke Yu Jiang Chang Lixuan Wei Yu-Tang Gao Woon-Puay Koh Yong-Bing Xiang Ze-Zhong Tang Jin-Hu Fan Jing-Jing Han Sheng-Li Zhou Peng Zhang Dong-Yun Zhang Yuan Yuan Ying Huang Chunling Liu Kan Zhai Yan Qiao Guangfu Jin Chuanhai Guo Jianhua Fu Xiaoping Miao Changdong Lu Haijun Yang Chaoyu Wang William A Wheeler Mitchell Gail Meredith Yeager Jeff Yuenger Er-Tao Guo Ai-Li Li Wei Zhang Xue-Min Li Liang-Dan Sun Bao-Gen Ma Yan Li Sa Tang Xiu-Qing Peng Jing Liu Amy Hutchinson Kevin Jacobs Carol Giffen Laurie Burdette Joseph F Fraumeni Hongbing Shen Yang Ke Yixin Zeng Tangchun Wu Peter Kraft Charles C Chung Margaret A Tucker Zhi-Chao Hou Ya-Li Liu Yan-Long Hu Yu Liu Li Wang Guo Yuan Li-Sha Chen Xiao Liu Teng Ma Hui Meng Li Sun Xin-Min Li Xiu-Min Li Jian-Wei Ku Ying-Fa Zhou Liu-Qin Yang Zhou Wang Yin Li Qirenwang Qige Wen-Jun Yang Guang-Yan Lei Long-Qi Chen En-Min Li Ling Yuan Wen-Bin Yue Ran Wang Lu-Wen Wang Xue-Ping Fan Fang-Heng Zhu Wei-Xing Zhao Yi-Min Mao Mei Zhang Guo-Lan Xing Ji-Lin Li Min Han Jing-Li Ren Bin Liu Shu-Wei Ren Qing-Peng Kong Feng Li Ilyar Sheyhidin Wu Wei Yan-Rui Zhang Chang-Wei Feng Jin Wang Yu-Hua Yang Hong-Zhang Hao Qi-De Bao Bao-Chi Liu Ai-Qun Wu Dong Xie Wan-Cai Yang Liang Wang Xiao-Hang Zhao Shu-Qing Chen Jun-Yan Hong Xue-Jun Zhang Neal D Freedman Alisa M Goldstein Dongxin Lin Philip R Taylor Li-Dong Wang Stephen J Chanock

Nat Genet 2014 Sep 17;46(9):1001-1006. Epub 2014 Aug 17.

Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/ng.3064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212832PMC
September 2014

High expression of H3K27me3 is an independent predictor of worse outcome in patients with urothelial carcinoma of bladder treated with radical cystectomy.

Biomed Res Int 2013 4;2013:390482. Epub 2013 Sep 4.

State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, China ; Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, China.

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http://dx.doi.org/10.1155/2013/390482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777191PMC
June 2014

α4 contributes to bladder urothelial carcinoma cell invasion and/or metastasis via regulation of E-cadherin and is a predictor of outcome in bladder urothelial carcinoma patients.

Eur J Cancer 2014 Mar 2;50(4):840-51. Epub 2014 Jan 2.

State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangdong, Guangzhou 510060, China; Department of Pathology, Sun Yat-Sen University Cancer Center, Guangdong, Guangzhou 510060, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2013.11.038DOI Listing
March 2014

Expression of variant isoforms of the tyrosine kinase SYK determines the prognosis of hepatocellular carcinoma.

Cancer Res 2014 Mar 29;74(6):1845-56. Epub 2014 Jan 29.

Authors' Affiliations: State Key Laboratory of Oncology in South China; Department of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center; Department of Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; and Division of Pharmacy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959256PMC
March 2014

Scavenger receptor B1 is a potential biomarker of human nasopharyngeal carcinoma and its growth is inhibited by HDL-mimetic nanoparticles.

Theranostics 2013 25;3(7):477-86. Epub 2013 Jun 25.

Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan 430074, China.

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http://dx.doi.org/10.7150/thno.6617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706691PMC
February 2014

Risk prediction of esophageal squamous-cell carcinoma with common genetic variants and lifestyle factors in Chinese population.

Carcinogenesis 2013 Aug 27;34(8):1782-6. Epub 2013 Mar 27.

State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1093/carcin/bgt106DOI Listing
August 2013

Policy dialogue on China's changing burden of disease.

Lancet 2013 Jun;381(9882):1961-2

Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/S0140-6736(13)61031-4DOI Listing
June 2013

Rapid health transition in China, 1990-2010: findings from the Global Burden of Disease Study 2010.

Lancet 2013 Jun;381(9882):1987-2015

Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1016/S0140-6736(13)61097-1DOI Listing
June 2013

The case-only test for gene-environment interaction is not uniformly powerful: an empirical example.

Genet Epidemiol 2013 May 13;37(4):402-7. Epub 2013 Mar 13.

Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1002/gepi.21713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858433PMC
May 2013

Forum on frontiers of science and technology: lifeomics and translational medicine.

Sci China Life Sci 2013 Mar 23;56(3):199-200. Epub 2013 Mar 23.

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http://dx.doi.org/10.1007/s11427-013-4463-7DOI Listing
March 2013

[Bacterial diversity within different sections of summer sea-ice samples from the Prydz Bay, Antarctica].

Wei Sheng Wu Xue Bao 2013 Feb;53(2):185-96

SOA Key Laboratory for Polar Science, Polar Research Institute of China, Shanghai 200136, China.

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February 2013

Targeted and personalized therapy for cancer: theory and practice in China.

Sci China Life Sci 2011 Dec 7;54(12):1081-4. Epub 2012 Jan 7.

State Key Laboratory of Oncology in South China, Guangzhou 510060, China.

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http://dx.doi.org/10.1007/s11427-011-4253-zDOI Listing
December 2011

Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.

Nat Genet 2011 Jun 5;43(7):679-84. Epub 2011 Jun 5.

State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://www.nature.com/articles/ng.849
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http://dx.doi.org/10.1038/ng.849DOI Listing
June 2011

Static pressure accelerates ox-LDL-induced cholesterol accumulation via SREBP-1-mediated caveolin-1 downregulation in cultured vascular smooth muscle cells.

Biochem Biophys Res Commun 2010 Dec 29;403(1):52-8. Epub 2010 Oct 29.

Department of Pharmacology, School of Pharmaceutics, Central South University, Changsha 410083, Hunan, China.

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http://dx.doi.org/10.1016/j.bbrc.2010.10.111DOI Listing
December 2010

14-3-3 mediates apelin-13-induced enhancement of adhesion of monocytes to human umbilical vein endothelial cells.

Acta Biochim Biophys Sin (Shanghai) 2010 Jun;42(6):403-9

Institute of Pharmacy and Pharmacology, University of South China, Hengyang, China.

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http://dx.doi.org/10.1093/abbs/gmq036DOI Listing
June 2010

Synergism of BARF1 with Ras induces malignant transformation in primary primate epithelial cells and human nasopharyngeal epithelial cells.

Neoplasia 2009 Sep;11(9):964-73

Department of Thoracic Oncology, Tianjin Lung Cancer Center, Tianjin Cancer Institute & Hospital, Tianjin Medical University, Tianjin 300060, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735807PMC
http://dx.doi.org/10.1593/neo.09706DOI Listing
September 2009

A major EBNA1 variant from Asian EBV isolates shows enhanced transcriptional activity compared to prototype B95.8.

Virus Res 2008 Mar 21;132(1-2):15-24. Epub 2007 Dec 21.

Department of Microbiology, Tumor and Cell Biology , Karolinska Institutet, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.virusres.2007.10.020DOI Listing
March 2008

Minicircle-IFNgamma induces antiproliferative and antitumoral effects in human nasopharyngeal carcinoma.

Clin Cancer Res 2006 Aug;12(15):4702-13

State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, PR China.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-06-0520DOI Listing
August 2006

Oncogenic transformation by SEI-1 is associated with chromosomal instability.

Cancer Res 2005 Aug;65(15):6504-8

Department of Clinical Oncology, The University of Hong Kong Medical Center, Hong Kong SAR, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-0351DOI Listing
August 2005

A rare polymorphism of the COX7B2 gene in a Cantonese family with nasopharyngeal carcinoma.

Sci China C Life Sci 2004 Oct;47(5):449-53

Cancer Center, Sun Yat-sen University, Guangzhou 510060, China.

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http://dx.doi.org/10.1360/03yc0037DOI Listing
October 2004

[Differentially expressed gene in nasopharyngeal carcinoma cell lines with various metastatic potentialities].

Zhonghua Zhong Liu Za Zhi 2002 Sep;24(5):430-4

Cancer Center, Sun Yat-sen University, Guangzhou 510060, China.

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September 2002

High frequency loss of heterozygosity on the long arms of chromosomes 13 and 14 in nasopharyngeal carcinoma in Southern China.

Chin Med J (Engl) 2002 Apr;115(4):571-5

Cancer Center, Sun Yat-Sen University of Medical Sciences, Guangzhou 510060, China.

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April 2002

Rapid tissue microarray assay of p16 protein expression for different stage nasopharyngeal carcinoma.

Zhonghua Bing Li Xue Za Zhi 2002 Apr;31(2):132-4

Department of Etiology, Cancer Institute, Cancer Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060. China (Email:

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April 2002