Publications by authors named "Yining Wang"

253 Publications

Domain Adaptation for Medical Image Segmentation: A Meta-Learning Method.

J Imaging 2021 Feb 10;7(2). Epub 2021 Feb 10.

Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA.

Convolutional neural networks (CNNs) have demonstrated great achievement in increasing the accuracy and stability of medical image segmentation. However, existing CNNs are limited by the problem of dependency on the availability of training data owing to high manual annotation costs and privacy issues. To counter this limitation, domain adaptation (DA) and few-shot learning have been extensively studied. Inspired by these two categories of approaches, we propose an optimization-based meta-learning method for segmentation tasks. Even though existing meta-learning methods use prior knowledge to choose parameters that generalize well from few examples, these methods limit the diversity of the task distribution that they can learn from in medical image segmentation. In this paper, we propose a meta-learning algorithm to augment the existing algorithms with the capability to learn from diverse segmentation tasks across the entire task distribution. Specifically, our algorithm aims to learn from the diversity of image features which characterize a specific tissue type while showing diverse signal intensities. To demonstrate the effectiveness of the proposed algorithm, we conducted experiments using a diverse set of segmentation tasks from the Medical Segmentation Decathlon and two meta-learning benchmarks: model-agnostic meta-learning (MAML) and Reptile. U-Net and Dice similarity coefficient (DSC) were selected as the baseline model and the main performance metric, respectively. The experimental results show that our algorithm maximally surpasses MAML and Reptile by 2% and 2.4% respectively, in terms of the DSC. By showing a consistent improvement in subjective measures, we can also infer that our algorithm can produce a better generalization of a target task that has few examples.
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http://dx.doi.org/10.3390/jimaging7020031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321260PMC
February 2021

Early soft tissue response to zirconium oxide and titanium healing abutments in vivo: a study in dogs.

BMC Oral Health 2021 Aug 24;21(1):416. Epub 2021 Aug 24.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education and Department of Oral Implantology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.

Background: This study aimed to investigate the clinical characteristics and early soft tissue response to zirconium oxide (Zr) and titanium (Ti) healing abutments in dogs.

Methods: Eight implants (four at each hemi-mandible) were inserted after bilateral mandibular third and fourth premolars and first molar extraction in dogs. Then, two Zr and two Ti healing abutments were connected to each unilateral mandible eight weeks later. The ligation method was used to create a peri-implant mucositis model and the 24 abutments were divided into four groups: Zr or Ti healing abutments with ligation (ZrL, TiL) or non-ligation (ZrN, TiN). The clinical indices, peri-implant crevicular fluid (PICF), and inflammatory cytokines (TNF-α and IL-1β) were measured and analyzed on days 0 and 28. The dogs were then sacrificed on day 28, soft tissues around the implants were harvested, and inflammation infiltration was tested by immunohistochemistry. Normal distribution test and two-way analysis of variance was used to analyze the data.

Results: The results showed that the clinical indices were similar for Zr and Ti healing abutments. There was significantly more PICF in the ZrL and TiL groups compared to in the ZrN and TiN groups. The TNF-α levels in PICF were significantly different between ZrL and ZrN groups on day 28. And the TNF-α levels in PICF were significantly higher in TiL group on day 28 than that on day 0. However, the number of inflammatory cells was not significantly different between the groups as measured by immunohistochemistry.

Conclusions: These data indicate that soft tissue responses to Zr healing abutments with peri-implant mucositis were comparable to those of Ti healing abutments in vivo, providing a theoretical foundation for the clinical application of Zr abutments.
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http://dx.doi.org/10.1186/s12903-021-01748-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383379PMC
August 2021

LncRNA AC020978 facilitates non-small cell lung cancer progression by interacting with malate dehydrogenase 2 and activating the AKT pathway.

Cancer Sci 2021 Aug 23. Epub 2021 Aug 23.

Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Long non-coding RNA AC020978 (lncRNA AC020978) is an oncogenic regulator of non-small cell lung cancer (NSCLC). However, the function of AC020978 in regulating NSCLC metastasis and the potential molecular mechanism remains largely unknown. In this study, we evaluated the expression levels of AC020978 in a series of NSCLC tissues using FISH assays and found that higher AC020978 expression levels were closely associated with metastasis and unfavorable prognosis. Functional studies showed that AC020978 promoted NSCLC migration and invasion both in vitro and in vivo. Further investigation demonstrated that AC020978 interacted with malate dehydrogenase 2 (MDH2) and maintained MDH2 stability. Knockdown of MDH2 weakened the facilitating effect on cell metastasis and 2-hydroxyglutarate (2-HG) metabolism in AC020978-overexpressed NSCLC cells. RNA sequencing, bioinformatic analysis, and western blotting revealed that AC020978 was associated with the AKT signaling pathway. Taken together, our findings revealed that AC020978 might serve as a prognostic biomarker and activate the AKT pathway by stabilizing MDH2, leading to metastasis and progression of NSCLC.
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http://dx.doi.org/10.1111/cas.15116DOI Listing
August 2021

Hepatitis E virus infection activates NLRP3 inflammasome antagonizing interferon response but therapeutically targetable.

Hepatology 2021 Aug 15. Epub 2021 Aug 15.

Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.

Background & Aims: Hepatitis E virus (HEV) infection is the most common cause of liver inflammation, but the pathogenic mechanisms remain largely unclear. We aim to explore whether HEV infection activates inflammasomes, the crosstalk with antiviral interferon response and potential of therapeutic targeting.

Approach & Results: We measured IL-1β secretion, the hallmark of inflammasome activation, in serum of HEV-infected patients and rabbits, and in cultured macrophage cell lines and primary monocyte-derived macrophages. We found that genotypes 3 and 4 HEV infection in rabbits elevated IL-1β production. A profound increase of IL-1β secretion was further observed in HEV-infected patients (1733 pg/mL ± 1234; n = 70) compared with healthy individuals (731 pg/mL ± 701; n = 70). As macrophages are the drivers of inflammatory response, we found inoculation with infectious HEV particles robustly triggered NLRP3 inflammasome activation in primary macrophages and macrophage cell lines. We further revealed that the ORF2 capsid protein and the formed integral viral particles are responsible for activating inflammasome response. We also identified NF-κB signaling activation as a key upstream event of HEV-induced NLRP3 inflammasome response. Interestingly, inflammasome activation antagonizes interferon response to facilitate viral replication in macrophages. Pharmacological inhibitors and clinically used steroids can effectively target inflammasome activation. Combining steroids with ribavirin simultaneously inhibit HEV and inflammasome response without cross-interference.

Conclusions: HEV infection strongly activates NLRP3 inflammasome activation in macrophages, which regulates host innate defense and pathogenesis. Therapeutic targeting NLRP3, in particular when combined with antiviral agents, represents a viable option for treating severe HEV infection.
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http://dx.doi.org/10.1002/hep.32114DOI Listing
August 2021

Patchouli Alcohol Improves the Integrity of the Blood-Spinal Cord Barrier by Inhibiting Endoplasmic Reticulum Stress Through the Akt/CHOP/Caspase-3 Pathway Following Spinal Cord Injury.

Front Cell Dev Biol 2021 22;9:693533. Epub 2021 Jul 22.

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Spinal cord injury (SCI) is a destructive and complex disorder of the central nervous system (CNS) for which there is no clinical treatment. Blood-spinal cord barrier (BSCB) rupture is a critical event in SCI that aggravates nerve injury. Therefore, maintaining the integrity of the BSCB may be a potential method to treat SCI. Here, we showed that patchouli alcohol (PA) exerts protective effects against SCI. We discovered that PA significantly prevented hyperpermeability of the BSCB by reducing the loss of tight junctions (TJs) and endothelial cells. PA also suppressed endoplasmic reticulum stress and apoptosis . Furthermore, in a rat model of SCI, PA effectively improved neurological deficits. Overall, these results prove that PA exerts neuroprotective effects by maintaining BSCB integrity and thus be a promising candidate for SCI treatment.
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http://dx.doi.org/10.3389/fcell.2021.693533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339579PMC
July 2021

Nonenhanced Chemical Exchange Saturation Transfer Cardiac Magnetic Resonance Imaging in Patients With Amyloid Light-Chain Amyloidosis.

J Magn Reson Imaging 2021 Jul 29. Epub 2021 Jul 29.

Department of Radiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Dongcheng District, Beijing, 100730, China.

Background: Chemical exchange saturation transfer (CEST) is an emerging metabolic MRI technique to map creatine distribution in the myocardium.

Purpose: To investigate the feasibility of using a contrast-free CEST technique to evaluate cardiac involvement in amyloid light-chain (AL) amyloidosis.

Study Type: Prospective.

Population: Forty patients with biopsy-proven AL amyloidosis (age 57.6 ± 9.1 years, 31 males) and 20 healthy controls (age 42.8 ± 13.8 years, 13 males).

Field Strength/sequence: A 3.0 T, CEST imaging using a single-shot FLASH sequence, T1 mapping with a modified Look-Locker inversion recovery sequence and late gadolinium enhancement (LGE) imaging with a phase-sensitive inversion recovery gradient echo sequence.

Assessment: The average CEST was calculated in the basal short-axis slice of the entire left ventricle and septum. LGE was assessed subjectively (none/patchy/global) and extracellular volume (ECV), CEST and T1 maps generated.

Statistical Tests: Comparison between patient groups and healthy controls was performed by one-way analysis of variance with post hoc Bonferroni correction. Correlation was assessed using the Pearson's r correlation or Spearman ρ correlation. Statistical significance was defined as P < 0.05.

Results: Global (0.09 ± 0.03 vs. 0.11 ± 0.02) and septal (0.09 ± 0.03 vs. 0.11 ± 0.03) basal short-axis CEST was significantly decreased in patients with AL amyloidosis compared to the controls. Global CEST correlated significantly with Mayo stage (ρ = -0.508), NYHA Class (ρ = -0.430), LVEF (r = 0.511), mass index (r = -0.373), LGE (ρ = -0.537), ECV (r = -0.544), and T2 (r = -0.396). Septal CEST correlated significantly with LVEF (r = 0.395), LGE (ρ = -0.330), and ECV (r = -0.391).

Data Conclusions: This study highlights the potential of CEST MRI to identify cardiac involvement and evaluate disease burden and to give insight into cellular changes intermediary between function and structure in AL amyloidosis patients.

Evidence Level: 2 TECHNICAL EFFICACY: Stage 2.
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http://dx.doi.org/10.1002/jmri.27859DOI Listing
July 2021

Incremental improvement of diagnostic performance of coronary CT angiography for the assessment of coronary stenosis in the presence of calcium using a dual-layer spectral detector CT: validation by invasive coronary angiography.

Int J Cardiovasc Imaging 2021 Aug 27;37(8):2561-2572. Epub 2021 Jun 27.

Department of Radiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , No.1, Shuaifuyuan, Dongcheng District, Beijing, 100730, China.

To investigate value of spectral reconstructions for the quantification of coronary stenosis in the presence of calcified or partially calcified plaques using a dual-layer spectral detector CT (SDCT). Seventy-two consecutive patients were retrospectively enrolled. Conventional 120 kVp images, eight virtual monoenergetic images (VMI) (70 to 140 keV), the effective atomic number (Z effective) and iodine no water images were reconstructed. Invasive coronary angiography was used as the reference standard. Parallel and serial testing were used to assess the incremental diagnostic value of Z effective and iodine no water images to the best VMI series. 122 coronary lesions of 72 patients (49 men and 23 women; 63.7 ± 10.2 years) were enrolled in analysis. Reconstruction at 100 keV yielded optimal diagnostic performance, the sensitivity, specificity, PPV, NPV and diagnostic accuracy to identify stenosis ≥ 50% or ≥ 70% were 84%, 70%, 80%, 76%, 79% and 78%, 98%, 93%, 91%, 92%, respectively. A serial combination (100 keV VMI followed by Z effective images) resulted in an improved specificity (from 70 to 80%) with a moderate loss of sensitivity (81% from 84%) in identifying ≥ 50% stenosis (P = 0.021). For patients with high Agatston score, this combination could further reduce false positive cases and improve diagnostic accuracy. 100 keV VMI provide optimal diagnostic performance for the detection of coronary stenosis in the presence of calcified or partially calcified plaques using a dual-layer SDCT, with further improvements obtained with the combined use of Z effective images.
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http://dx.doi.org/10.1007/s10554-021-02205-3DOI Listing
August 2021

Ordered multi-path propagation for vessel centerline extraction.

Phys Med Biol 2021 Jul 19;66(15). Epub 2021 Jul 19.

Laboratory of Beijing Engineering Research Center of Mixed Reality and Advanced Display, School of Optics and Photonics, Beijing Institute of Technology, Beijing 100081, People's Republic of China.

Vessel centerline extraction from x-ray angiography images is essential for vessel structure analysis in the diagnosis of coronary artery disease. However, complete and continuous centerline extraction remains a challenging task due to image noise, poor contrast, and complexity of vessel structure. Thus, an iterative multi-path search framework for automatic vessel centerline extraction is proposed. First, the seed points of the vessel structure are detected and sorted by confidence. With the ordered seed points, multi-bifurcation centerline is searched through multi-path propagation of wavefront and accumulated voting. Finally, the centerline is further extended piecewise by wavefront propagation on the basis of keypoint detection. The latter two steps are performed alternately to obtain the final centerline result. The proposed method is qualitatively and quantitatively evaluated on 1260 synthetic images and 50 clinical angiography images. The results demonstrate that our method has a highF1score of 87.8% ± 2.7% for the angiography images and achieves accurate and continuous results of vessel centerline extraction.
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http://dx.doi.org/10.1088/1361-6560/ac0d8eDOI Listing
July 2021

The Heterogeneous Metabolic Patterns of Ganglia in Ga-PSMA, C-choline, and F-FDG PET/CT in Prostate Cancer Patients.

Front Oncol 2021 23;11:666308. Epub 2021 Apr 23.

Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Purpose: Studies have indicated that PSMA-positive ganglia represent a diagnostic pitfall for nuclear medicine physicians. No studies have described choline and FDG uptake in ganglia, which may be a source of misdiagnosis. Herein, we described the percentage and uptake pattern of Ga-PSMA, C-choline and F-FDG PET/CT in ganglia and evaluated the heterogeneous metabolic patterns of ganglia to differentiate from lymph node metastases (LNM).

Methods: Thirty-nine patients who underwent C-choline PET/CT and 120 patients who underwent Ga-PSMA PET/CT and F-FDG PET/CT were retrospectively analyzed. The prevalence of PSMA-positive, choline-positive and FDG-positive ganglia was determined, the SUVmax of ganglia in different locations were measured, and the configuration was described. The SUVmax cutoff of PSMA-PET, choline-PET and FDG-PET was determined by ROC curve analysis to differentiate ganglia from LNM.

Results: 329 PSMA-positive ganglia were identified in 120 patients, 95 choline-positive ganglia were identified in 39 patients, and 39 FDG-positive ganglia were identified in 34 patients. PSMA-positive uptake was observed in 98.3%, 95.8%, and 80.0% of cervical, coeliac, and sacral ganglia, respectively. Choline-positive uptake was observed in 84.6%, 97.4%, and 61.5% of cervical, coeliac, and sacral ganglia, respectively. FDG-positive uptake was observed in 16.7%, 13.3%, and 2.5% of cervical, coeliac, and sacral ganglia, respectively. Cervical and coeliac ganglia had a higher rate of PSMA-positive uptake than sacral ganglia. Choline uptake was highest in coeliac ganglia followed by cervical and sacral ganglia. PSMA, choline or FDG uptake in LNM was all significantly higher than ganglia. ROC curve analysis revealed that at a 4.1 SUVmax cutoff of PSMA-PET, the sensitivity, specificity and accuracy of LNM identification was 88.4%, 97.9% and 96.2%, respectively. ROC curve analysis revealed that at a 2.35 SUVmax cutoff for choline-PET, the sensitivity, specificity, and accuracy of LNM identification was 95.0%, 92.6% and 93.0%, respectively. ROC curve analysis revealed that at a 2.55 SUVmax cutoff for FDG-PET, the sensitivity, specificity, and accuracy of LNM identification was 77.3%, 87.2%, and 81.9%, respectively. PSMA-, Choline- and FDG-positive ganglia are mainly band-shaped; most LNMs exhibited nodular and teardrop-shaped configuration.

Conclusion: Ga-PSMA and C-choline uptake in ganglia was common, and FDG-positive ganglia were observed at lower frequency. Using Ga-PSMA, C-choline and F-FDG uptake and anatomic location and configuration, the differentiation of ganglia from adjacent LNM is feasible.
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http://dx.doi.org/10.3389/fonc.2021.666308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103210PMC
April 2021

The added value of F-FDG PET/CT compared to Ga-PSMA PET/CT in patients with castration-resistant prostate cancer.

J Nucl Med 2021 Apr 23. Epub 2021 Apr 23.

Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University,, China.

The Ga-PSMA PET/CT is a commonly used imaging modality in prostate cancers. However, few studies have compared the diagnostic efficiency between Ga-PSMA and F-FDG PET/CT and evaluated whether a heterogeneous metabolic phenotype (especially PSMA-FDG+ lesions) exists in patients with castration-resistant prostate cancer (CRPC). We determined the added value of F-FDG PET/CT compared to Ga-PSMA PET/CT in CRPC patients and identified CRPC patients who may benefit from additional F-FDG PET/CT. Data of 56 patients with CRPC who underwent both Ga-PSMA and F-FDG PET/CT from May 2018 to February 2021 were retrospectively analysed. Patients were classified into two groups with or without PSMA-FDG+ lesions. The differences in patient characteristics between the two groups and predictors of patients who having at least one PSMA-FDG+ lesion were analysed. Although both the detection rate (75.0% vs. 51.8%, = 0.004) and positive lesion number (135 vs. 95) of Ga-PSMA PET/CT were higher than F-FDG PET/CT, there were still 13/56 (23.2%) patients with at least one PSMA-FDG+ lesion. The prostate-specific antigen (PSA) and Gleason score were both higher in the patients with PSMA-FDG+ lesions than in those without PSMA-FDG+ lesions ( = 0.04 and P<0.001, respectively). Multivariate regression analysis showed that the Gleason score (≥8) and PSA (≥7.9 ng/mL) were associated with the detection rate of patients who had PSMA-FDG+ lesions ( = 0.01 and = 0.04, respectively). The incidences of having PSMA-FDG+ lesions in low-probability (Gleason score<8 and PSA<7.9 ng/mL), medium-probability (Gleason score≥8 and PSA<7.9 ng/mL or Gleason score<8 and PSA≥7.9 ng/mL), and high-probability (Gleason score≥8 and PSA≥7.9 ng/mL) groups were 0%, 21.7%, and 61.5%, respectively (P<0.001). Gleason score and PSA are significant predictors for PSMA-FDG+ lesions, and CRPC patients with high Gleason score and PSA may benefit from additional F-FDG PET/CT.
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http://dx.doi.org/10.2967/jnumed.121.262250DOI Listing
April 2021

Noninvasive Detection of Cardiac Amyloid With 11C-Pittsburgh Compound B PET/CT and 99mTc-PYP Scintigraphy.

Clin Nucl Med 2021 Sep;46(9):776-778

Cardiology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, China.

Abstract: We report the imaging findings of 2 cases of cardiac amyloidosis, one light chain (AL) type and another transthyretin (ATTR) type. The images showed 11C-Pittsburgh compound B (11C-PIB) uptake in the heart with AL amyloidosis, whereas the ATTR amyloidosis showed 11C-PIB-negative and 99mTc-PYP-positive uptake in the heart. It demonstrated that using 99mTc-PYP scintigraphy and 11C-PIB PET/CT might be able to differentiate these 2 major types of cardiac amyloidosis noninvasively.
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http://dx.doi.org/10.1097/RLU.0000000000003665DOI Listing
September 2021

An innovative coupled model in view of wavelet transform for predicting short-term PM10 concentration.

J Environ Manage 2021 Jul 16;289:112438. Epub 2021 Apr 16.

Faculty of Architecture, Civil and Transportation Engineering, Beijing University of Technology, Beijing, 100124, China. Electronic address:

Wavelet transform (WT) is an advanced preprocessing technique, which has been widely used in PM 10 prediction. However, this technique cannot provide stable performance due to the empirical selection of wavelet's layers. For fixing the optimal wavelet's layers in PM10 forecasting, an innovative coupled model based on WT, long short-term memory (LSTM), and SAE (stacked autoencoder) are proposed. This study designs a crossover experiment with 960 high- and low-frequency components by wavelet decomposition and predicts each component with SAE-LSTM based on 12 samples from different regions. The results indicate that the developed model outperforms other BiLSTM (Biredictional LSTM) and LSTM based on some error evaluation indicators (i.e. Nash-Sutcliffe efficiency coefficient (NSEC)), and compared with other steps, the accuracy of two-step prediction is the highest in view of root mean squares error (RMSE). In addition, for 12 samples, the prediction accuracy by using high layers is higher than that by adopting low layers for decomposing them. This paper fixes the optimal wavelet' layers in PM10 prediction, which provides a meaningful reference in other prediction scenarios based on the application of WT.
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http://dx.doi.org/10.1016/j.jenvman.2021.112438DOI Listing
July 2021

Using deep learning to predict microvascular invasion in hepatocellular carcinoma based on dynamic contrast-enhanced MRI combined with clinical parameters.

J Cancer Res Clin Oncol 2021 Apr 10. Epub 2021 Apr 10.

Department of Liver Surgery, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.

Purpose: Microvascular invasion (MVI) is a critical determinant of the early recurrence and poor prognosis of patients with hepatocellular carcinoma (HCC). Prediction of MVI status is clinically significant for the decision of treatment strategies and the assessment of patient's prognosis. A deep learning (DL) model was developed to predict the MVI status and grade in HCC patients based on preoperative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and clinical parameters.

Methods: HCC patients with pathologically confirmed MVI status from January to December 2016 were enrolled and preoperative DCE-MRI of these patients were collected in this study. Then they were randomly divided into the training and testing cohorts. A DL model with eight conventional neural network (CNN) branches for eight MRI sequences was built to predict the presence of MVI, and further combined with clinical parameters for better prediction.

Results: Among 601 HCC patients, 376 patients were pathologically MVI absent, and 225 patients were MVI present. To predict the presence of MVI, the DL model based only on images achieved an area under curve (AUC) of 0.915 in the testing cohort as compared to the radiomics model with an AUC of 0.731. The DL combined with clinical parameters (DLC) model yielded the best predictive performance with an AUC of 0.931. For the MVI-grade stratification, the DLC models achieved an overall accuracy of 0.793. Survival analysis demonstrated that the patients with DLC-predicted MVI status were associated with the poor overall survival (OS) and recurrence-free survival (RFS). Further investigation showed that hepatectomy with the wide resection margin contributes to better OS and RFS in the DLC-predicted MVI present patients.

Conclusion: The proposed DLC model can provide a non-invasive approach to evaluate MVI before surgery, which can help surgeons make decisions of surgical strategies and assess patient's prognosis.
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http://dx.doi.org/10.1007/s00432-021-03617-3DOI Listing
April 2021

Use of Ga-PSMA-11 and F-FDG PET-CT Dual-Tracer to Differentiate Between Lymph Node Metastases and Ganglia.

Front Oncol 2021 10;11:646110. Epub 2021 Mar 10.

Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Purpose: Differentiating lymph node metastases (LNM) from peripheral ganglia by physiological prostate-specific membrane antigen (PSMA) uptake is challenging. Two tracers (Ga-PSMA-11 and F-fluorodeoxyglucose [FDG]) metabolic uptake patterns were evaluated by positron emission tomography-computed tomography (PET-CT), searching for differences that could tell ganglia from LNM.

Methods: Dual Ga-PSMA-11 and F-FDG PET-CT data of 138 prostate cancer patients acquired from June 2018 to December 2019 were retrospectively evaluated. Ganglia and LNM with PSMA-11 uptake above local background were analyzed by the location and PSMA-11-PET and FDG-PET maximum standardized uptake value (SUVmax).

Results: PSMA-11-positive ganglia (n = 381) and LNM (n = 83) were identified in 138 and 58 patients, respectively. The LNM SUVmax of PSMA-11-PET (16.4 ± 14.8 vs 2.3 ± 0.7, < 0.001) and FDG-PET (3.3 ± 3.2 vs 1.5 ± 0.5, < 0.001) were higher than in ganglia. The probabilities of being an LNM in the low-potential (PSMA-11-PET SUVmax of <4.1 and FDG-PET SUVmax of <2.05), moderate-potential (PSMA-11-PET SUVmax of >4.1 and FDG-PET SUVmax of <2.05, or PSMA-11-PET SUVmax of <4.1 and FDG-PET SUVmax of >2.05), and high-potential (PSMA-11-PET SUVmax of >4.1 and FDG-PET SUVmax of >2.05) groups were 0.9% (3/334), 44.6% (37/83), and 91.5% (43/47), respectively ( < 0.001). The cervical and coeliac ganglia had higher PSMA-11 and FDG uptake than the sacral ganglia (P < 0.001 for all). LNM PSMA-11 and FDG uptake was similar in these three locations.

Conclusion: The FDG-PET and PSMA-11-PET SUVmax, especially when combined, could well differentiate LNM from ganglia. The tracers uptake differed between cervical/coeliac and sacral ganglia, so the lesion location should be considered during image assessment.
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http://dx.doi.org/10.3389/fonc.2021.646110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987919PMC
March 2021

Anion Exchange of Ruddlesden-Popper Lead Halide Perovskites Produces Stable Lateral Heterostructures.

J Am Chem Soc 2021 Apr 24;143(13):5212-5221. Epub 2021 Mar 24.

Department of Chemistry, University of Wisconsin - Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.

Heterostructures of three-dimensional (3D) halide perovskites are unstable because of facile anion interdiffusion at halide interfaces. Two-dimensional (2D) Ruddlesden-Popper halide perovskites (RPPs) show suppressed and anisotropic ion diffusion that could enable stable RPP heterostructures, yet the direct and general growth of lateral RPP heterostructures remains challenging. Here, we show that halide miscibility in RPPs decreases with perovskite layer thickness (), enabling the formation of sharp halide lateral heterostructures from = 1 and 2 RP lead iodide microplates via anion exchange with hydrogen bromide vapor. In contrast, RPPs with ≥ 3 form more diffuse lateral heterojunctions, more similar to those in 3D perovskites. The anion exchange behaviors are further modulated by the spacer and A-site cations in the RPP structures. These new insights, and kinetic studies of the exchange reactions, enable the preparation of lateral heterostructures from various = 2 RPPs that are more stable against anion interdiffusion and degradation for potential optoelectronic device applications.
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http://dx.doi.org/10.1021/jacs.1c01573DOI Listing
April 2021

Cardiac Phenotype Characterization at MRI in Patients with Danon Disease: A Retrospective Multicenter Case Series.

Radiology 2021 05 23;299(2):303-310. Epub 2021 Mar 23.

From the Department of Radiology (X.W., X.Z., W.Y., H.L.) and Guangdong Cardiovascular Institute (Y.L.), Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhong Shan Er Lu, Guangzhou, Guangdong Province 510080, China; School of Medicine, South China University of Technology, Guangzhou, China (X.W., H.L.); Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing, China (L.Z.); Department of Radiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China (J.X.); Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, China (Z.D.); Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China (Y.W.); Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China (Y.C.); Department of Magnetic Resonance Imaging, Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (M.L.); The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China (H.L.).

Danon disease (DD) is a rare X-chromosome-linked dominant lysosomal glycogen storage disease. Its features have seldom been reported by using cardiac MRI. This case series aimed to evaluate cardiac features of DD on the basis of MRI observations from five centers in China. From January 2010 to May 2019, 16 patients with DD (13 male patients [81%]; median age, 19 years; age range, 14-44 years) underwent MRI. The most frequent DD cardiomyopathy manifestation was symmetric hypertrophy cardiomyopathy (HCM) phenotype (nine of 16; 56%), followed by asymmetric HCM phenotype (six of 16; 38%) and dilated cardiomyopathy phenotype (one of 16; 6%). The characteristic late gadolinium enhancement features included midbasal septum sparing (14 of 16; 88%) and apex involvement (16 of 16; 100%) with a base-to-apex increasing tendency, free wall involvement (15 of 16; 94%), and extensive subendocardium involvement (14 of 16; 88%). Abnormal T2 signal (seven of 16; 44%) and resting perfusion defect (14 of 16; 88%) were not uncommon in patients with DD. Furthermore, the cardiac MRI features of DD cohort in this study were compared with those of DD in previous literature and with genetically confirmed sarcomeric HCM.
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http://dx.doi.org/10.1148/radiol.2021203996DOI Listing
May 2021

Left-behind children's social adjustment and relationship with parental coping with children's negative emotions during the COVID-19 pandemic in China.

Int J Psychol 2021 Aug 19;56(4):512-521. Epub 2021 Mar 19.

School of Educational Sciences, Xingyi Nationalities Normal College, Xingyi, China.

Using data collected from two provinces in China through an online survey, the current study aimed to investigate left-behind children's emotional and academic adjustment during the COVID-19 pandemic in China. The participants included 1780 left-behind (960 boys) and 1500 non-left-behind (811 boys) children in elementary and junior high school with a mean age of 11.23. Self-reported questionnaires concerning children's depression, loneliness, anxiety, and academic adjustment, and parents' coping with children's negative emotions were completed. The results suggested that compared with non-left-behind children, left-behind children's depression and anxiety symptoms were more severe and their academic adjustment was poorer. However, left-behind children had lower levels of loneliness than non-left-behind children. Additionally, supportive coping types, especially emotion-focused and problem-focused reactions, were significantly negatively correlated with children's depression and anxiety. Unsupportive coping types, especially distress and punitive reactions, were significantly positively correlated with children's depression and anxiety symptoms. Moreover, the relationships between punitive reactions and depression, ignoring and loneliness and problem-focused reactions and academic adjustment were significantly stronger in left-behind children. Hence, during the pandemic, left-behind children were still at a disadvantage even with their parents' company. However, parents' coping style towards left-behind children's negative emotions played a significant role in their adjustment.
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http://dx.doi.org/10.1002/ijop.12754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251002PMC
August 2021

Application of ultrasound technology in the field of solid-state fermentation: increasing peptide yield through ultrasound-treated bacterial strain.

J Sci Food Agric 2021 Oct 26;101(13):5348-5358. Epub 2021 Mar 26.

School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China.

Background: The increase of peptide yield contributed to reducing the usage of antibiotics in solid-state fermented feed. Ultrasound technology is used in the field of liquid-state fermentation to improve yield of fermented products but has not been utilized in the field of solid-state fermentation (SSF). The main objective of this study was to investigate the feasibility of improving peptide yield in SSF products through ultrasound-treated bacterial strain.

Results: The highest peptides content in soybean meal SSF products reached 153.28 mg g , which increased by 15.05% compared with the control. This content value was acquired through treating the bacteria of Bacillus amyloliquefaciens by ultrasound before inoculating into soybean meal under the optimized mode and parameters (simultaneous dual-frequency ultrasound mode, frequency combination of 40/60 kHz, total power density of 40 W L , time of 20 min, pulse-on and pulse-off times of 40 and 60 s, delayed inoculation time of 0 h). Fermenting with ultrasound-treated bacterial strain can effectively increase peptide yield, biomass and protease activity of soybean meal fermented products during the SSF prophase. After treating by ultrasound, the latent phase and logarithmic phase of the bacterial strain shortened by 1 and 3 h while the generation time reduced by 23.64%. In qualitative test of protease activity, diameter ratio (DR) value of ultrasound-treated bacterial cells enlarged by 12.0% compared with the control.

Conclusion: Peptide yield of soybean meal SSF products can be improved through ultrasound-treated bacterial inoculum, which attributed to the promoting effect of ultrasound treatment on growth activity and protease production capability of bacterial cells. © 2021 Society of Chemical Industry.
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http://dx.doi.org/10.1002/jsfa.11183DOI Listing
October 2021

The Efficacy and Safety of the mTOR Signaling Pathway Activator, MHY1485, for Activation of Human Ovarian Tissue.

Front Genet 2020 4;11:603683. Epub 2021 Feb 4.

Shanghai Key Laboratory of Embryo Original Diseases, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Premature ovarian insufficiency (POI) is characterized by abnormal ovarian function before the age of 40. POI showed that primordial follicles developed in disorder. mTOR signaling plays a vital role in the process of follicle development. It has been verified that the mTOR signaling pathway activator, MHY1485, can promote primordial follicle development in mice. We considered that MHY1485 would be a promising fertility preservation method for POI patients.

Methods: The fragmented ovarian tissues of normal woman was cultured with activator MHY1485 , and then the control and activated ovaries were transplanted into the kidney capsules of ovariectomized mice. We then used the Infinium Human Methylation EPIC BeadChip to verify the DNA methylation level of ovarian tissues, thus exploring the effectiveness of them.

Results: MHY1485 stimulated mTOR, S6K1, and rpS6 phosphorylation. Cultured with MHY1485, ovarian weights increased and endocrine function was restored. The number of growing follicles was increased. The activation process did not induce histological changes or abnormal DNA methylation occurrence.

Conclusion: MHY1485 for activation (IVA) is effective for ovarian rejuvenation and is a potential therapeutic treatment for POI patients.
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http://dx.doi.org/10.3389/fgene.2020.603683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890121PMC
February 2021

Diagnostic value of F-FDG PET/CT in patients with biochemical recurrent prostate cancer and negative Ga-PSMA PET/CT.

Eur J Nucl Med Mol Imaging 2021 08 2;48(9):2970-2977. Epub 2021 Feb 2.

Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Purpose: Ga-PSMA PET/CT has a high detection rate in prostate cancer patients with biochemical recurrence (BCR). However, few studies have reported other imaging methods for BCR with negative Ga-PSMA PET/CT findings. We investigated the value of F-FDG compared with Ga-PSMA and identified BCR patients with Ga-PSMA-negative findings who are most likely to benefit from F-FDG PET/CT.

Methods: Seventy-two BCR patients with negative Ga-PSMA PET/CT findings were retrospectively identified from 510 patients who underwent concomitant Ga-PSMA and F-FDG PET/CT between June 2018 and August 2020. Patients were categorised into groups with positive or negative F-FDG PET/CT findings. Differences in patients' characteristics between these two groups and predictors of positive F-FDG findings were analysed.

Results: The detection rate of F-FDG PET/CT was 16.7% (12/72) in BCR patients with Ga-PSMA-negative findings. PSA and Gleason score were significantly higher in the F-FDG-positive group than in the F-FDG-negative group (P < 0.001 and P < 0.001, respectively). A multivariate analysis indicated that PSA (PSA ≥2.3 ng/mL) and Gleason score (Gleason score ≥ 8) correlated with F-FDG-positive findings (P < 0.001 and P = 0.015, respectively). The probabilities of F-FDG-positive findings in the low-potential (PSA <2.3 ng/mL and Gleason score <8), moderate-potential (PSA <2.3 ng/mL and Gleason score ≥ 8 or PSA ≥2.3 ng/mL and Gleason score <8), and high-potential (PSA ≥2.3 ng/mL and Gleason score ≥ 8) groups were 0%, 11.5%, and 90.0%, respectively (P < 0.001).

Conclusion: PSA level and Gleason score are independent predictors of F-FDG-positive findings, and BCR patients with Ga-PSMA-negative findings with high PSA and Gleason score are most likely to benefit from F-FDG PET/CT.
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http://dx.doi.org/10.1007/s00259-021-05221-6DOI Listing
August 2021

Development of Microsatellite Marker System to Determine the Genetic Diversity of Experimental Chicken, Duck, Goose, and Pigeon Populations.

Biomed Res Int 2021 14;2021:8851888. Epub 2021 Jan 14.

Capital Medical University, School of Basic Medical Sciences, Beijing 100069, China.

Poultries including chickens, ducks, geese, and pigeons are widely used in the biological and medical research in many aspects. The genetic quality of experimental poultries directly affects the results of the research. In this study, following electrophoresis analysis and short tandem repeat (STR) scanning, we screened out the microsatellite loci for determining the genetic characteristics of Chinese experimental chickens, ducks, geese, and pigeons. The panels of loci selected in our research provide a good choice for genetic monitoring of the population genetic diversity of Chinese native experimental chickens, ducks, geese, and ducks.
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http://dx.doi.org/10.1155/2021/8851888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822670PMC
June 2021

Quick evaluation of lower leg ischemia in patients with peripheral arterial disease by time maximum intensity projection CT angiography: a pilot study.

BMC Med Imaging 2021 01 6;21(1). Epub 2021 Jan 6.

Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: The purpose of this study is to evaluate a new method involving time maximum intensity projection (t-MIP) postprocessed from dynamic computed tomographic angiography (dyn-CTA) in diagnosing peripheral arterial disease (PAD).

Methods: A population of 34 patients with known PAD was examined with a combined CTA protocol consisting of a standard CTA (s-CTA) scan of the lower extremities and a dyn-CTA scan of the calves. For each lower leg, t-MIP images consisting of the MIP (sagittal MIP), MIP (45° lateral MIP), and MIP (- 45° lateral MIP) were automatically generated from dyn-CTA. An objective evaluation of the vascular CT attenuation of the best enhancement phase of dyn-CTA and t-MIP was measured; a subjective evaluation of vessel stenosis and occlusion was performed, assigning a score for t-MIP and s-CTA. The CT attenuation of t-MIP and dyn-CTA was compared, as were the runoff scores of t-MIP and s-CTA.

Results: The CT attenuation of t-MIP CTA of three vascular segments from 68 lower extremities was higher than that of the best enhancement phase of dyn-CTA and s-CTA, with statistically significant differences at the posterior tibial artery and fibular artery (all p < 0.05). There were strong correlations (r ≥ 0.75, p < 0.05) of the runoff scores between t-MIP and s-CTA.

Conclusions: There is potential clinical applicability of t-MIP in assisting with the diagnosis of lower leg vascular stenosis in dyn-CTA with reliable diagnostic accuracy and convenient immediacy.
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http://dx.doi.org/10.1186/s12880-020-00537-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789570PMC
January 2021

Molecular Examination of Ion-Pair Competition in Alkaline Aluminate Solutions Using In Situ Liquid SIMS.

Anal Chem 2021 Jan 7;93(2):1068-1075. Epub 2020 Dec 7.

Pacific Northwest National Laboratory, 902 Battelle Blvd, Richland, Washington 99354, United States.

Understanding the structure and composition of aluminate complexes in extremely alkaline systems such as Bayer liquors has received enormous attention due to their fundamental and industrial importance. However, obtaining direct molecular information of the underlying ion-ion interactions using traditional approaches such as NMR spectroscopy or Raman spectroscopy is challenging due to the weakness of these interactions and/or their complex overlapping spectral signatures. Here, we exploit in situ liquid secondary-ion mass spectrometry (SIMS) as a new approach and show how it enables new insights. In contrast with traditional techniques, using SIMS we succeeded in acquiring information on dominant ion clusters in these alkaline systems. In Na/K mixed alkaline aluminate solutions, we clearly observe preferential formation of Na-anion clusters over K-anion clusters. Evaluation of these clusters by density functional theory (DFT) calculations shows that these structures are stable and that their relative bond energies are consistent with their observed SIMS signal intensity differences. This demonstrates a key advantage of in situ liquid SIMS for overcoming ambiguities obscuring important information in these systems on constituent molecular clusters defined by relatively weak ion-pair competition and ion-solvent interactions.
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http://dx.doi.org/10.1021/acs.analchem.0c04070DOI Listing
January 2021

PD-1/PD-L1 expression profiles within intrahepatic cholangiocarcinoma predict clinical outcome.

World J Surg Oncol 2020 Nov 23;18(1):303. Epub 2020 Nov 23.

Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.

Objective: Immunotherapy targeting the programmed cell death protein-1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) pathway has been observed to be efficient in several solid tumors. We aim to investigate the prognostic significance of PD-1/PD-L1 expression profile in intrahepatic cholangiocarcinoma (ICC).

Materials And Methods: We investigated the expression of PD-1, PD-L1, CD8 T cells, and CD68 macrophages in paired tumor and adjacent normal tissues from 322 ICC patients using tyramide signal amplification (TSA)-based multiplexed immunohistochemistry.

Results: We found that high proportion of tumor-infiltrating CD8 PD-1 within CD8 PD-1 T cells significantly correlated with advanced TNM stage (P = 0.035). ICC patients with high proportion of CD8 PD-1 in CD8 PD-1 had worse postoperative survival than low proportion patients (P = 0.0037), which was an independently prognostic factor for OS (P = 0.025,). The density of CD68 PD-L1 significantly and positively correlated with the density of CD8 PD-1 (P < 0.0001, r = 0.5927). The proportion of CD68 PD-L1 within CD68 ICC was the risk factor for OS and TTR but not an independently factor for prognosis. The CD68 PD-L1 macrophages and CD8 PD-1 T cells may cooperatively play a role in inhibiting anti-tumor immunity.

Conclusion: CD68 PD-L1 macrophages and CD8 PD-1 T cells predict unfavorable prognosis, which could also bring new progress about immune target therapy in ICC research.
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http://dx.doi.org/10.1186/s12957-020-02082-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686719PMC
November 2020

Facile Interfacial Synthesis of Densely Spiky Gold Nano-Chestnuts With Full Spectral Absorption for Photothermal Therapy.

Front Bioeng Biotechnol 2020 26;8:599040. Epub 2020 Oct 26.

Department of Neurosurgery, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.

The gold nanostructure is regarded as the most promising photothermal agent due to its strong localized surface plasma resonance (LSPR) effect. In particular, the gold nanostructures with sharp spikes on the surface have higher optical signal enhancement, owing to the sharp tips drastically enhancing the intense nanoantenna effect. However, current approaches for the synthesis of spiky gold nanostructures are either costly, complicated, or uncontrollable. Herein, we report a novel strategy to synthesize gold nano-chestnuts (SGNCs) with sharp spikes as an excellent photothermal agent. The SGNCs were prepared by a facile one-pot interfacial synthetic method, and their controllable preparation mechanism was acquired. The SGNCs exhibited ideal full-spectrum absorption and showed excellent photothermal effect. They have a photothermal conversion efficiency (η) as high as 52.9%, which is much higher than traditional photothermal agents. The and results show that the SGNCs could efficiently ablate the tumor cells. Thus, the SGNCs have great potential in photothermal therapy applied in malignant tumors.
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http://dx.doi.org/10.3389/fbioe.2020.599040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649415PMC
October 2020

Reversibility of Cardiac Involvement in Acromegaly Patients After Surgery: 12-Month Follow-up Using Cardiovascular Magnetic Resonance.

Front Endocrinol (Lausanne) 2020 21;11:598948. Epub 2020 Oct 21.

Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Purpose: Cardiac comorbidity is one of the leading causes of death among acromegaly patients. We aimed to investigate the reversibility of acromegalic cardiac involvement after surgical treatment using the gold standard method, cardiovascular magnetic resonance, and to explore the effects of endocrine remission and gender on reversibility.

Methods: In this single-center, prospective cohort study, fifty untreated acromegaly patients were enrolled. Comprehensive cardiac assessments were performed using a 3.0 T magnetic resonance scanner before and 3 and 12 months after transsphenoidal adenomectomy.

Results: Preoperatively, left ventricular (LV) enlargement (13.0%), LV systolic dysfunction (6.5%), right ventricular (RV) enlargement (4.3%), RV systolic dysfunction (2.2%) and myocardial fibrosis (12.0%) were identified. On average, the LV and RV ejection fractions of acromegaly patients were higher than the healthy reference values. Male patients had thicker LV myocardia, wider ventricular diameters and more dilated pulmonary artery roots than female patients. After surgery, LV myocardial hypertrophy was reversed, the left atrium was remodeled, and ventricular systolic dysfunction recovered to normal. Cardiac alterations were detected early in the 3 postoperative month and persisted until the 12 month. The interventricular septum was initially thickened in the 3 postoperative month and then recovered at the 12th month. Notable postoperative cardiac reversibility was observed in male patients but did not occur in all female patients. Patients achieving endocrine remission with normalized hormone levels had thinner LV myocardia than patients without normalized hormone levels.

Conclusion: Our findings demonstrated that some of the cardiac involvement in acromegaly patients is reversible after surgical treatment which lowers hormone levels. Endocrine remission and gender significantly impacted postoperative cardiac reversibility.
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http://dx.doi.org/10.3389/fendo.2020.598948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609918PMC
June 2021

Systematically comparing COVID-19 with the 2009 influenza pandemic for hospitalized patients.

Int J Infect Dis 2021 Jan 12;102:375-380. Epub 2020 Nov 12.

Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands; Biomedical Research Center, Northwest Minzu University, Lanzhou, China. Electronic address:

Objectives: This study aimed to comprehensively compare the clinical features of hospitalized COVID-19 patients with hospitalized 2009 influenza pandemic patients.

Methods: Medline, Embase, Web of Science, Cochrane CENTRAL, and Google scholar were systematically searched to identify studies related to COVID-19 and the 2009 influenza pandemic. The pooled incidence rates of clinical features were estimated using the DerSimonian-Laird random-effects model with the Freeman-Tukey double arcsine transformation method.

Results: The incidence rates of fever, cough, shortness of breath, sore throat, rhinorrhea, myalgia/muscle pain, or vomiting were found to be significantly higher in influenza patients when compared with COVID-19 patients. The incidence rates of comorbidities, including cardiovascular disease/hypertension and diabetes, were significantly higher in COVID-19 compared with influenza patients. In contrast, comorbidities such as asthma, chronic obstructive pulmonary disease, and immunocompromised conditions were significantly more common in influenza compared with COVID-19 patients. Unexpectedly, the estimated rates of intensive care unit admission, treatment with extracorporeal membrane oxygenation, treatment with antibiotics, and fatality were comparable between hospitalized COVID-19 and 2009 influenza pandemic patients.

Conclusions: This study comprehensively estimated the differences and similarities of the clinical features and burdens of hospitalized COVID-19 and 2009 influenza pandemic patients. This information will be important to better understand the current COVID-19 pandemic.
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http://dx.doi.org/10.1016/j.ijid.2020.11.127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658594PMC
January 2021

Diffused coronary arteritis in undifferentiated connective tissue disease identified with coronary atherosclerosis T1-weighted charac terization (CATCH).

Eur Heart J Cardiovasc Imaging 2021 May;22(6):e73

Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1, Shuaifuyuan, Dongcheng District, Beijing, 100730, China.

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http://dx.doi.org/10.1093/ehjci/jeaa278DOI Listing
May 2021

Delayed F-FDG PET/CT Appearance of Urachal Adenocarcinomas.

Contrast Media Mol Imaging 2020 14;2020:3216179. Epub 2020 Sep 14.

Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Urachal carcinoma is a rare urological malignancy. Use of F-FDG PET/CT in urological oncology has developed slowly because of the urinary elimination of F-FDG. We investigated whether delayed postdiuretic F-FDG PET/CT could be used for diagnosing urachal carcinoma.

Methods: This retrospective study included 6 patients who underwent delayed postdiuretic F-FDG PET/CT for the evaluation of urachal carcinoma. The delayed postdiuretic PET/CT parameters and clinical characteristics of urachal carcinoma were investigated.

Results: There was no significant difference in the SUVmax between the primary tumors and the urine in the bladder before delayed diuresis (25.4 ± 19.5 vs. 42.9 ± 31.1, =0.18). However, the SUVmax of the primary tumors was significantly higher than the SUVmax of urine after delayed diuresis (25.4 ± 19.5 vs. 3.5 ± 1.6, =0.002). Diuretic F-FDG PET/CT was positive in all patients when compared with normal liver tissues or urine after delayed diuresis. The SUVmax, TLR, and TUR of the primary tumors were 25.4 (range: 7.2-58.9), 7.0 (range: 1.8-14.7), and 6.8 (range: 3.8-11.3), respectively. Delayed postdiuretic F-FDG PET/CT had a negative predictive value of 100% (5/5) for predicting lymph node metastasis. One patient received chemotherapy after radical resection of urachal carcinoma because F-FDG PET/CT found lung metastases, and one patient only received chemotherapy because PET/CT found peritoneal and skeletal metastases.

Conclusions: Delayed postdiuretic F-FDG PET/CT is a useful tool for the preoperative evaluation of urachal carcinoma. F-FDG PET/CT may improve clinical decision making and management of urachal carcinomas.
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http://dx.doi.org/10.1155/2020/3216179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509541PMC
September 2020
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