Yingyan Yu

Yingyan Yu

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Expression pattern of CDK12 protein in gastric cancer and its positive correlation with CD8 cell density and CCL12 expression.

Int J Med Sci 2019 6;16(8):1142-1148. Epub 2019 Aug 6.

Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin er Road, Shanghai, 200025, China.

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http://www.medsci.org/v16p1142.htm
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http://dx.doi.org/10.7150/ijms.34541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743279PMC
August 2019

A positive feedback between IDO1 metabolite and COL12A1 via MAPK pathway to promote gastric cancer metastasis.

J Exp Clin Cancer Res 2019 Jul 17;38(1):314. Epub 2019 Jul 17.

Department of Surgery of Ruijin Hospital, and Shanghai Key Laboratory for Gastric Neoplasms, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1186/s13046-019-1318-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637527PMC
July 2019

HUPAN: a pan-genome analysis pipeline for human genomes.

Genome Biol 2019 07 31;20(1):149. Epub 2019 Jul 31.

School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.

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https://genomebiology.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13059-019-1751-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670167PMC
July 2019

Identification of discrepancy between CTLA4 expression and CTLA4 activation in gastric cancer.

Immunopharmacol Immunotoxicol 2019 Jun 13;41(3):386-393. Epub 2018 Nov 13.

e Department of Gastrointestinal Surgery , The General Hospital of Ningxia Medical University , Yinchuan , China.

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https://www.tandfonline.com/doi/full/10.1080/08923973.2018.1
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http://dx.doi.org/10.1080/08923973.2018.1533968DOI Listing
June 2019

A Novel Citrullinated Modification of Histone 3 and Its Regulatory Mechanisms Related to IPO-38 Antibody-Labeled Protein.

Front Oncol 2019 18;9:304. Epub 2019 Apr 18.

Department of Surgery, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory for Gastric Neoplasms, Shanghai, China.

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http://dx.doi.org/10.3389/fonc.2019.00304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482251PMC
April 2019

Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases.

Front Med 2019 Feb 18;13(1):24-31. Epub 2019 Jan 18.

Department of Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

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http://dx.doi.org/10.1007/s11684-019-0679-7DOI Listing
February 2019

LncRNAs GIHCG and SPINT1-AS1 Are Crucial Factors for Pan-Cancer Cells Sensitivity to Lapatinib.

Front Genet 2019 19;10:25. Epub 2019 Feb 19.

Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA, United States.

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http://dx.doi.org/10.3389/fgene.2019.00025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391897PMC
February 2019

Progression on Citrullination of Proteins in Gastrointestinal Cancers.

Front Oncol 2019 23;9:15. Epub 2019 Jan 23.

Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory for Gastric Neoplasms, Shanghai, China.

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http://dx.doi.org/10.3389/fonc.2019.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357933PMC
January 2019

Protein arginine methyltransferase 5-mediated epigenetic silencing of IRX1 contributes to tumorigenicity and metastasis of gastric cancer.

Biochim Biophys Acta Mol Basis Dis 2018 09 23;1864(9 Pt B):2835-2844. Epub 2018 May 23.

Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254439183018
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http://dx.doi.org/10.1016/j.bbadis.2018.05.015DOI Listing
September 2018

Difference of molecular alterations in HER2-positive and HER2-negative gastric cancers by whole-genome sequencing analysis.

Cancer Manag Res 2018 26;10:3945-3954. Epub 2018 Sep 26.

Department of Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China,

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http://dx.doi.org/10.2147/CMAR.S172710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165778PMC
September 2018

HGF derived from cancer‑associated fibroblasts promotes vascularization in gastric cancer via PI3K/AKT and ERK1/2 signaling.

Oncol Rep 2018 Aug 18;40(2):1185-1195. Epub 2018 Jun 18.

Department of Oncology, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China.

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http://dx.doi.org/10.3892/or.2018.6500DOI Listing
August 2018

UBE2C Is a Potential Biomarker of Intestinal-Type Gastric Cancer With Chromosomal Instability.

Front Pharmacol 2018 2;9:847. Epub 2018 Aug 2.

Department of Surgery, Ruijin Hospital, Shanghai Key Laboratory for Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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https://www.frontiersin.org/article/10.3389/fphar.2018.00847
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http://dx.doi.org/10.3389/fphar.2018.00847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082955PMC
August 2018

Cross-Database Analysis Reveals Sensitive Biomarkers for Combined Therapy for ERBB2+ Gastric Cancer.

Front Pharmacol 2018 3;9:861. Epub 2018 Aug 3.

Department of Surgery, Ruijin Hospital, Shanghai Institute of Digestive Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai, China.

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https://www.frontiersin.org/article/10.3389/fphar.2018.00861
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http://dx.doi.org/10.3389/fphar.2018.00861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085474PMC
August 2018

HGF-mediated crosstalk between cancer-associated fibroblasts and MET-unamplified gastric cancer cells activates coordinated tumorigenesis and metastasis.

Cell Death Dis 2018 08 29;9(9):867. Epub 2018 Aug 29.

Department of Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No. 197 Ruijin Er Road, Shanghai, 200025, China.

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http://dx.doi.org/10.1038/s41419-018-0922-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115420PMC
August 2018

Molecular classification and precision therapy of cancer: immune checkpoint inhibitors.

Authors:
Yingyan Yu

Front Med 2018 Apr 5;12(2):229-235. Epub 2017 Dec 5.

Department of Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

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http://dx.doi.org/10.1007/s11684-017-0581-0DOI Listing
April 2018

Metronomic chemotherapy remodel cancer-associated fibroblasts to decrease chemoresistance of gastric cancer in nude mice.

Oncol Lett 2017 Dec 16;14(6):7903-7909. Epub 2017 Oct 16.

Department of Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China.

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http://dx.doi.org/10.3892/ol.2017.7197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755147PMC
December 2017

Pulmonary CCR2CD4 T cells are immune regulatory and attenuate lung fibrosis development.

Thorax 2017 11 5;72(11):1007-1020. Epub 2017 Aug 5.

Comprehensive Pneumology Center, Helmholtz Center Munich Germany, Member of the German Center for Lung Research (DZL), Munich, Germany.

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http://dx.doi.org/10.1136/thoraxjnl-2016-208423DOI Listing
November 2017

EGFR High Expression, but not KRAS Status, Predicts Sensitivity of Pancreatic Cancer Cells to Nimotuzumab Treatment In Vivo.

Curr Cancer Drug Targets 2017 ;17(1):89-97

Department of Oncology, RuiJin Hospital, Shanghai Jiaotong University School of Medicine, No. 197 Ruijiner Road, Shanghai 200025, China.

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http://dx.doi.org/10.2174/1568009616666161013101657DOI Listing
October 2017

MiR-148a Functions as a Tumor Suppressor by Targeting CCK-BR via Inactivating STAT3 and Akt in Human Gastric Cancer.

PLoS One 2016 12;11(8):e0158961. Epub 2016 Aug 12.

Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158961PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982598PMC
July 2017

A hydrophobic residue in the TALE homeodomain of PBX1 promotes epithelial-to-mesenchymal transition of gastric carcinoma.

Oncotarget 2017 Jul;8(29):46818-46833

Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.18632/oncotarget.17473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564525PMC
July 2017

PKM2 promotes cell migration and inhibits autophagy by mediating PI3K/AKT activation and contributes to the malignant development of gastric cancer.

Sci Rep 2017 06 6;7(1):2886. Epub 2017 Jun 6.

Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Er Road, Shanghai, 200025, China.

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http://dx.doi.org/10.1038/s41598-017-03031-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460252PMC
June 2017

Fbxw7 haploinsufficiency loses its protection against DNA damage and accelerates MNU-induced gastric carcinogenesis.

Oncotarget 2017 May;8(20):33444-33456

Department of Surgery of Shanghai Ruijin Hospital, Shanghai Institute of Digestive Surgery, Shanghai Key Laboratory for Gastric Neoplasms, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

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http://dx.doi.org/10.18632/oncotarget.16800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464881PMC
May 2017

Deubiquitinating enzyme USP20 is a positive regulator of Claspin and suppresses the malignant characteristics of gastric cancer cells.

Int J Oncol 2017 Mar 8. Epub 2017 Mar 8.

Department of Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China.

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http://dx.doi.org/10.3892/ijo.2017.3904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363881PMC
March 2017

Transgenic and gene knockout mice in gastric cancer research.

Oncotarget 2017 Jan;8(2):3696-3710

Department of Surgery of Ruijin Hospital and Shanghai Institute of Digestive Surgery, Shanghai Key Laboratory for Gastric Neoplasms, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.18632/oncotarget.12467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356912PMC
January 2017

A characteristic biosignature for discrimination of gastric cancer from healthy population by high throughput GC-MS analysis.

Oncotarget 2016 Dec;7(52):87496-87510

Department of Surgery of Ruijin Hospital, and Shanghai Institute of Digestive Surgery, Shanghai Key Laboratory for Gastric Neoplasms, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.18632/oncotarget.11754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350005PMC
December 2016

DBGC: A Database of Human Gastric Cancer.

PLoS One 2015 13;10(11):e0142591. Epub 2015 Nov 13.

School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142591PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643992PMC
July 2016

Mitochondrial aldehyde dehydrogenase 2 protects gastric mucosa cells against DNA damage caused by oxidative stress.

Free Radic Biol Med 2016 Apr 5;93:165-76. Epub 2016 Feb 5.

Department of Surgery, Ruijin Hospital, Shanghai Institute of Digestive Surgery and Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin er Road, Shanghai 200025, People's Republic of China; Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200025, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.02.001DOI Listing
April 2016

Stomach virtual non-enhanced CT with second-generation, dual-energy CT: a preliminary study.

PLoS One 2014 13;9(11):e112295. Epub 2014 Nov 13.

Shanghai Institute of Digestive Surgery, Shanghai Jiaotong University School of Medicine, Shanghai, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0112295PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231030PMC
January 2016

Cetuximab inhibits gastric cancer growth in vivo, independent of KRAS status.

Curr Cancer Drug Targets 2014 ;14(2):217-24

Departments of Surgery and Clinical Oncology, Shanghai Institute of Digestive Surgery, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, No. 197 Ruijin Er Road, Shanghai 200025, China.

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http://dx.doi.org/10.2174/1570163811666140127145031DOI Listing
June 2015

KRAS and DAXX/ATRX gene mutations are correlated with the clinicopathological features, advanced diseases, and poor prognosis in Chinese patients with pancreatic neuroendocrine tumors.

Int J Biol Sci 2014 30;10(9):957-65. Epub 2014 Aug 30.

1. Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No. 197 Ruijin Er Road, Shanghai 200025, China; ; 2. Department of Clinical Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No. 197 Ruijin Er Road, Shanghai 200025, China;

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http://dx.doi.org/10.7150/ijbs.9773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159686PMC
May 2015

MTA2 enhances colony formation and tumor growth of gastric cancer cells through IL-11.

BMC Cancer 2015 May 2;15:343. Epub 2015 May 2.

Department of Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No. 197 Ruijin er Road, Shanghai, 200025, China.

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http://bmccancer.biomedcentral.com/articles/10.1186/s12885-0
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http://dx.doi.org/10.1186/s12885-015-1366-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419442PMC
May 2015

Capecitabine metronomic chemotherapy inhibits the proliferation of gastric cancer cells through anti-angiogenesis.

Oncol Rep 2015 Apr 29;33(4):1753-62. Epub 2015 Jan 29.

Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China.

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http://dx.doi.org/10.3892/or.2015.3765DOI Listing
April 2015

Pin1 is overexpressed and correlates with poor prognosis in gastric cancer.

Cell Biochem Biophys 2015 Mar;71(2):857-64

Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No. 197 Ruijin er Road, Shanghai, 200025, China.

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http://dx.doi.org/10.1007/s12013-014-0274-0DOI Listing
March 2015

Rac1 is correlated with aggressiveness and a potential therapeutic target for gastric cancer.

Int J Oncol 2015 Mar 13;46(3):1343-53. Epub 2015 Jan 13.

Department of Clinical Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China.

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http://dx.doi.org/10.3892/ijo.2015.2836DOI Listing
March 2015

The important molecular markers on chromosome 17 and their clinical impact in breast cancer.

Int J Mol Sci 2011 5;12(9):5672-83. Epub 2011 Sep 5.

Department of Surgery, School of Medicine, The Ninth People's Hospital of Shanghai Jiao Tong University, Shanghai 200011, China.

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http://dx.doi.org/10.3390/ijms12095672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189742PMC
February 2015

Reactivation of HIC-1 gene by saRNA inhibits clonogenicity and invasiveness in breast cancer cells.

Oncol Lett 2015 Jan 24;9(1):159-164. Epub 2014 Oct 24.

Department of Surgery, The Ninth People's Hospital of Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, P.R. China.

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http://dx.doi.org/10.3892/ol.2014.2633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246611PMC
January 2015

Claudin-1 enhances tumor proliferation and metastasis by regulating cell anoikis in gastric cancer.

Oncotarget 2015 Jan;6(3):1652-65

Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359322PMC
http://dx.doi.org/10.18632/oncotarget.2936DOI Listing
January 2015

[Bioinformatics of tumor molecular targets from big data].

Zhonghua Wei Chang Wai Ke Za Zhi 2015 Jan;18(1):9-12

Shanghai Institute of Digestive Surgery, Department of Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.

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January 2015

Small activating RNA restores the activity of the tumor suppressor HIC-1 on breast cancer.

PLoS One 2014 28;9(1):e86486. Epub 2014 Jan 28.

Department of Surgery, The Ninth People's Hospital of Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086486PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904905PMC
December 2014

Identification of differentially-expressed genes in intestinal gastric cancer by microarray analysis.

Genomics Proteomics Bioinformatics 2014 Dec 11;12(6):276-83. Epub 2014 Dec 11.

Laboratory of Molecular Oncology, MOE Key Laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital & Institute, Beijing 100142, China. Electronic address:

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http://dx.doi.org/10.1016/j.gpb.2014.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411479PMC
December 2014

DACT2 is frequently methylated in human gastric cancer and methylation of DACT2 activated Wnt signaling.

Am J Cancer Res 2014 19;4(6):710-24. Epub 2014 Nov 19.

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital #28 Fuxing Road, Beijing 100853, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266706PMC
December 2014

Suberoylanilide hydroxamic acid enhances the antitumor activity of oxaliplatin by reversing the oxaliplatin‑induced Src activation in gastric cancer cells.

Mol Med Rep 2014 Nov 9;10(5):2729-35. Epub 2014 Sep 9.

Department of Surgery, Shanghai Institute of Digestive Surgery, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China.

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http://dx.doi.org/10.3892/mmr.2014.2548DOI Listing
November 2014

Novel methodologies in analysis of small molecule biomarkers and living cells.

Tumour Biol 2014 Oct 14;35(10):9469-77. Epub 2014 Aug 14.

Department of Surgery, Shanghai Institute of Digestive Surgery, Shanghai Key Laboratory for Gastric Neoplasms, Shanghai Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Ruijin er Road, No. 197, 200025, Shanghai, China.

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http://link.springer.com/10.1007/s13277-014-2439-2
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http://dx.doi.org/10.1007/s13277-014-2439-2DOI Listing
October 2014

Anti-angiogenesis participates in antitumor effects of metronomic capecitabine on colon cancer.

Cancer Lett 2014 Jul 16;349(2):128-35. Epub 2014 Apr 16.

Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No. 197 Ruijin Er Road, Shanghai 200025, China; Department of Clinical Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No. 197 Ruijin Er Road, Shanghai 200025, China. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2014.04.002DOI Listing
July 2014

Tumor suppressor miR-24 restrains gastric cancer progression by downregulating RegIV.

Mol Cancer 2014 May 28;13:127. Epub 2014 May 28.

Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No 197 Ruijin er Road, Shanghai 200025, People's Republic of China.

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http://dx.doi.org/10.1186/1476-4598-13-127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041902PMC
May 2014

[Application of genetically engineered mice model in the research of gastrointestinal tumor].

Zhonghua Wei Chang Wai Ke Za Zhi 2014 Apr;17(4):407-10

Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.

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April 2014

Decrease of miR-202-3p expression, a novel tumor suppressor, in gastric cancer.

PLoS One 2013 25;8(7):e69756. Epub 2013 Jul 25.

Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069756PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723650PMC
March 2014

Epigenetic silencing of miR-338-3p contributes to tumorigenicity in gastric cancer by targeting SSX2IP.

PLoS One 2013 24;8(6):e66782. Epub 2013 Jun 24.

Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066782PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691322PMC
January 2014

Integrity of the LXXLL motif in Stat6 is required for the inhibition of breast cancer cell growth and enhancement of differentiation in the context of progesterone.

BMC Cancer 2014 Jan 8;14:10. Epub 2014 Jan 8.

Breast Department, International Peace Maternity and Child Health Hospital, Shanghai Jiaotong University, Shanghai 200030, People's Republic of China.

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http://dx.doi.org/10.1186/1471-2407-14-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021501PMC
January 2014

MiR-133b is frequently decreased in gastric cancer and its overexpression reduces the metastatic potential of gastric cancer cells.

BMC Cancer 2014 Jan 21;14:34. Epub 2014 Jan 21.

Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Road, Shanghai 200025, People's Republic of China.

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http://dx.doi.org/10.1186/1471-2407-14-34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925791PMC
January 2014

[Evaluation of traditional pathological classification at molecular classification era for gastric cancer].

Authors:
Yingyan Yu

Zhonghua Wei Chang Wai Ke Za Zhi 2014 Jan;17(1):18-20

Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Department of Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.

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January 2014

CRKL promotes cell proliferation in gastric cancer and is negatively regulated by miR-126.

Chem Biol Interact 2013 Nov 18;206(2):230-8. Epub 2013 Sep 18.

Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, 197 Rui Jin Er Road, Shanghai 20025, People's Republic of China; Shanghai Key Laboratory of Gastric Neoplasms, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, 197 Rui Jin Er Road, Shanghai 20025, People's Republic of China; Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, 197 Rui Jin Er Road, Shanghai 20025, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2013.09.003DOI Listing
November 2013

Overexpressed miR-301a promotes cell proliferation and invasion by targeting RUNX3 in gastric cancer.

J Gastroenterol 2013 Sep 22;48(9):1023-33. Epub 2013 Jan 22.

Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 197# Ruijin Er Road, Shanghai, 200025, People's Republic of China.

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http://link.springer.com/10.1007/s00535-012-0733-6
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http://dx.doi.org/10.1007/s00535-012-0733-6DOI Listing
September 2013

Inactivation of tumor suppressor gene HIC1 in gastric cancer is reversed via small activating RNAs.

Gene 2013 Sep 12;527(1):102-8. Epub 2013 Jun 12.

Department of Surgery, Shanghai Institute of Digestive Surgery, Shanghai Ruijin Hospital, Shanghai Key Laboratory for Gastric Neoplasms, Shanghai Jiao Tong University, School of Medicine, Ruijin er Road, No. 197, 200025 Shanghai, China.

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http://dx.doi.org/10.1016/j.gene.2013.05.034DOI Listing
September 2013

MTA2 promotes gastric cancer cells invasion and is transcriptionally regulated by Sp1.

Mol Cancer 2013 Sep 8;12(1):102. Epub 2013 Sep 8.

Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No, 197 Ruijin er Road, Shanghai 200025, P,R, China.

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http://dx.doi.org/10.1186/1476-4598-12-102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851872PMC
September 2013

Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancer.

Cancer Lett 2013 Jul 9;335(1):128-35. Epub 2013 Feb 9.

Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, PR China.

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http://dx.doi.org/10.1016/j.canlet.2013.02.002DOI Listing
July 2013

Synergistic antitumor effects of dasatinib and oxaliplatin in gastric cancer cells.

Cancer Chemother Pharmacol 2013 Jul 28;72(1):35-44. Epub 2013 May 28.

Department of Surgery, Shanghai Institute of Digestive Surgery, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, No. 197 Ruijin er Road, Shanghai, 200025, People's Republic of China.

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http://dx.doi.org/10.1007/s00280-013-2166-1DOI Listing
July 2013

Osteopontin splice variants differentially exert clinicopathological features and biological functions in gastric cancer.

Int J Biol Sci 2013 20;9(1):55-66. Epub 2012 Dec 20.

Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 197 Rui Jin Er Road, Shanghai 200025, People's Republic of China.

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http://dx.doi.org/10.7150/ijbs.5280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535534PMC
June 2013

A unique feature of iron loss via close adhesion of Helicobacter pylori to host erythrocytes.

PLoS One 2012 21;7(11):e50314. Epub 2012 Nov 21.

Shanghai Institute of Digestive Surgery and Department of Surgery, Shanghai Ruijin Hospital, Shanghai Key Laboratory for Gastric Neoplasia, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050314PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503993PMC
May 2013

Stromal fibroblasts in the microenvironment of gastric carcinomas promote tumor metastasis via upregulating TAGLN expression.

BMC Cell Biol 2013 Mar 19;14:17. Epub 2013 Mar 19.

Key Laboratory of Shanghai Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

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http://dx.doi.org/10.1186/1471-2121-14-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610155PMC
March 2013

Oncogenic miR-544 is an important molecular target in gastric cancer.

Anticancer Agents Med Chem 2013 Feb;13(2):270-5

Department of Surgery of Ruijin Hospital, Shanghai Key Laboratory for Gastric Neoplasia, Affiliated to Shanghai Jiao Tong University, School of Medicine, Ruijin er Road, No. 197, 200025, Shanghai, China.

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http://dx.doi.org/10.2174/1871520611313020013DOI Listing
February 2013

Editorial: translational medicine is promoting cross-talk of inter discipline.

Authors:
Yingyan Yu

Anticancer Agents Med Chem 2013 Feb;13(2):193-4

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http://dx.doi.org/10.2174/1871520611313020001DOI Listing
February 2013

Stat6 cooperates with Sp1 in controlling breast cancer cell proliferation by modulating the expression of p21(Cip1/WAF1) and p27 (Kip1).

Cell Oncol (Dordr) 2013 Feb 27;36(1):79-93. Epub 2012 Nov 27.

Breast Department, International Peace Maternity and Child Health Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.

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http://dx.doi.org/10.1007/s13402-012-0115-3DOI Listing
February 2013

ABO blood group system and gastric cancer: a case-control study and meta-analysis.

Int J Mol Sci 2012 Oct 17;13(10):13308-21. Epub 2012 Oct 17.

Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

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http://dx.doi.org/10.3390/ijms131013308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497328PMC
October 2012

MicroRNA-409-3p regulates cell proliferation and apoptosis by targeting PHF10 in gastric cancer.

Cancer Lett 2012 Jul 1;320(2):189-97. Epub 2012 Mar 1.

Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

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http://dx.doi.org/10.1016/j.canlet.2012.02.030DOI Listing
July 2012

Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK.

FEBS Lett 2012 Jul 4;586(16):2382-8. Epub 2012 Jun 4.

Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197# Ruijin Er Road, Shanghai 200025, People's Republic of China.

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http://dx.doi.org/10.1016/j.febslet.2012.05.050DOI Listing
July 2012

Hypermethylated FAM5C and MYLK in serum as diagnosis and pre-warning markers for gastric cancer.

Dis Markers 2012 ;32(3):195-202

Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.3233/DMA-2011-0877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826591PMC
June 2012

Hypermethylated DNA as potential biomarkers for gastric cancer diagnosis.

Clin Biochem 2011 Dec 16;44(17-18):1405-11. Epub 2011 Sep 16.

Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, People's Republic of China.

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http://dx.doi.org/10.1016/j.clinbiochem.2011.09.006DOI Listing
December 2011

P27(Kip1), regulated by glycogen synthase kinase-3β, results in HMBA-induced differentiation of human gastric cancer cells.

BMC Cancer 2011 Mar 27;11:109. Epub 2011 Mar 27.

Key Laboratory of Shanghai Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

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http://dx.doi.org/10.1186/1471-2407-11-109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078896PMC
March 2011

miR-126 functions as a tumour suppressor in human gastric cancer.

Cancer Lett 2010 Dec 8;298(1):50-63. Epub 2010 Jul 8.

Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai 20025, People's Republic of China.

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http://dx.doi.org/10.1016/j.canlet.2010.06.004DOI Listing
December 2010

miRNA-331-3p directly targets E2F1 and induces growth arrest in human gastric cancer.

Biochem Biophys Res Commun 2010 Jul 16;398(1):1-6. Epub 2010 May 16.

Department of Surgery, Shanghai Ruijin Hospital, Shanghai Institute of Digestive Surgery, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.

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http://dx.doi.org/10.1016/j.bbrc.2010.05.082DOI Listing
July 2010

Effect of a matrix metalloproteinase-12 inhibitor, S-1, on allergic airway disease phenotypes in mice.

Inflamm Res 2010 Jun 12;59(6):419-28. Epub 2010 Jan 12.

Department of Pharmacology, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.

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http://dx.doi.org/10.1007/s00011-009-0153-0DOI Listing
June 2010

A novel plant homeodomain finger 10-mediated antiapoptotic mechanism involving repression of caspase-3 in gastric cancer cells.

Mol Cancer Ther 2010 Jun 8;9(6):1764-74. Epub 2010 Jun 8.

Department of General Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.

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http://dx.doi.org/10.1158/1535-7163.MCT-09-1162DOI Listing
June 2010

International network of cancer genome projects.

Authors:
Thomas J Hudson Warwick Anderson Axel Artez Anna D Barker Cindy Bell Rosa R Bernabé M K Bhan Fabien Calvo Iiro Eerola Daniela S Gerhard Alan Guttmacher Mark Guyer Fiona M Hemsley Jennifer L Jennings David Kerr Peter Klatt Patrik Kolar Jun Kusada David P Lane Frank Laplace Lu Youyong Gerd Nettekoven Brad Ozenberger Jane Peterson T S Rao Jacques Remacle Alan J Schafer Tatsuhiro Shibata Michael R Stratton Joseph G Vockley Koichi Watanabe Huanming Yang Matthew M F Yuen Bartha M Knoppers Martin Bobrow Anne Cambon-Thomsen Lynn G Dressler Stephanie O M Dyke Yann Joly Kazuto Kato Karen L Kennedy Pilar Nicolás Michael J Parker Emmanuelle Rial-Sebbag Carlos M Romeo-Casabona Kenna M Shaw Susan Wallace Georgia L Wiesner Nikolajs Zeps Peter Lichter Andrew V Biankin Christian Chabannon Lynda Chin Bruno Clément Enrique de Alava Françoise Degos Martin L Ferguson Peter Geary D Neil Hayes Thomas J Hudson Amber L Johns Arek Kasprzyk Hidewaki Nakagawa Robert Penny Miguel A Piris Rajiv Sarin Aldo Scarpa Tatsuhiro Shibata Marc van de Vijver P Andrew Futreal Hiroyuki Aburatani Mónica Bayés David D L Botwell Peter J Campbell Xavier Estivill Daniela S Gerhard Sean M Grimmond Ivo Gut Martin Hirst Carlos López-Otín Partha Majumder Marco Marra John D McPherson Hidewaki Nakagawa Zemin Ning Xose S Puente Yijun Ruan Tatsuhiro Shibata Michael R Stratton Hendrik G Stunnenberg Harold Swerdlow Victor E Velculescu Richard K Wilson Hong H Xue Liu Yang Paul T Spellman Gary D Bader Paul C Boutros Peter J Campbell Paul Flicek Gad Getz Roderic Guigó Guangwu Guo David Haussler Simon Heath Tim J Hubbard Tao Jiang Steven M Jones Qibin Li Nuria López-Bigas Ruibang Luo Lakshmi Muthuswamy B F Francis Ouellette John V Pearson Xose S Puente Victor Quesada Benjamin J Raphael Chris Sander Tatsuhiro Shibata Terence P Speed Lincoln D Stein Joshua M Stuart Jon W Teague Yasushi Totoki Tatsuhiko Tsunoda Alfonso Valencia David A Wheeler Honglong Wu Shancen Zhao Guangyu Zhou Lincoln D Stein Roderic Guigó Tim J Hubbard Yann Joly Steven M Jones Arek Kasprzyk Mark Lathrop Nuria López-Bigas B F Francis Ouellette Paul T Spellman Jon W Teague Gilles Thomas Alfonso Valencia Teruhiko Yoshida Karen L Kennedy Myles Axton Stephanie O M Dyke P Andrew Futreal Daniela S Gerhard Chris Gunter Mark Guyer Thomas J Hudson John D McPherson Linda J Miller Brad Ozenberger Kenna M Shaw Arek Kasprzyk Lincoln D Stein Junjun Zhang Syed A Haider Jianxin Wang Christina K Yung Anthony Cros Anthony Cross Yong Liang Saravanamuttu Gnaneshan Jonathan Guberman Jack Hsu Martin Bobrow Don R C Chalmers Karl W Hasel Yann Joly Terry S H Kaan Karen L Kennedy Bartha M Knoppers William W Lowrance Tohru Masui Pilar Nicolás Emmanuelle Rial-Sebbag Laura Lyman Rodriguez Catherine Vergely Teruhiko Yoshida Sean M Grimmond Andrew V Biankin David D L Bowtell Nicole Cloonan Anna deFazio James R Eshleman Dariush Etemadmoghadam Brooke B Gardiner Brooke A Gardiner James G Kench Aldo Scarpa Robert L Sutherland Margaret A Tempero Nicola J Waddell Peter J Wilson John D McPherson Steve Gallinger Ming-Sound Tsao Patricia A Shaw Gloria M Petersen Debabrata Mukhopadhyay Lynda Chin Ronald A DePinho Sarah Thayer Lakshmi Muthuswamy Kamran Shazand Timothy Beck Michelle Sam Lee Timms Vanessa Ballin Youyong Lu Jiafu Ji Xiuqing Zhang Feng Chen Xueda Hu Guangyu Zhou Qi Yang Geng Tian Lianhai Zhang Xiaofang Xing Xianghong Li Zhenggang Zhu Yingyan Yu Jun Yu Huanming Yang Mark Lathrop Jörg Tost Paul Brennan Ivana Holcatova David Zaridze Alvis Brazma Lars Egevard Egor Prokhortchouk Rosamonde Elizabeth Banks Mathias Uhlén Anne Cambon-Thomsen Juris Viksna Fredrik Ponten Konstantin Skryabin Michael R Stratton P Andrew Futreal Ewan Birney Ake Borg Anne-Lise Børresen-Dale Carlos Caldas John A Foekens Sancha Martin Jorge S Reis-Filho Andrea L Richardson Christos Sotiriou Hendrik G Stunnenberg Giles Thoms Marc van de Vijver Laura van't Veer Fabien Calvo Daniel Birnbaum Hélène Blanche Pascal Boucher Sandrine Boyault Christian Chabannon Ivo Gut Jocelyne D Masson-Jacquemier Mark Lathrop Iris Pauporté Xavier Pivot Anne Vincent-Salomon Eric Tabone Charles Theillet Gilles Thomas Jörg Tost Isabelle Treilleux Fabien Calvo Paulette Bioulac-Sage Bruno Clément Thomas Decaens Françoise Degos Dominique Franco Ivo Gut Marta Gut Simon Heath Mark Lathrop Didier Samuel Gilles Thomas Jessica Zucman-Rossi Peter Lichter Roland Eils Benedikt Brors Jan O Korbel Andrey Korshunov Pablo Landgraf Hans Lehrach Stefan Pfister Bernhard Radlwimmer Guido Reifenberger Michael D Taylor Christof von Kalle Partha P Majumder Rajiv Sarin T S Rao M K Bhan Aldo Scarpa Paolo Pederzoli Rita A Lawlor Massimo Delledonne Alberto Bardelli Andrew V Biankin Sean M Grimmond Thomas Gress David Klimstra Giuseppe Zamboni Tatsuhiro Shibata Yusuke Nakamura Hidewaki Nakagawa Jun Kusada Tatsuhiko Tsunoda Satoru Miyano Hiroyuki Aburatani Kazuto Kato Akihiro Fujimoto Teruhiko Yoshida Elias Campo Carlos López-Otín Xavier Estivill Roderic Guigó Silvia de Sanjosé Miguel A Piris Emili Montserrat Marcos González-Díaz Xose S Puente Pedro Jares Alfonso Valencia Heinz Himmelbauer Heinz Himmelbaue Victor Quesada Silvia Bea Michael R Stratton P Andrew Futreal Peter J Campbell Anne Vincent-Salomon Andrea L Richardson Jorge S Reis-Filho Marc van de Vijver Gilles Thomas Jocelyne D Masson-Jacquemier Samuel Aparicio Ake Borg Anne-Lise Børresen-Dale Carlos Caldas John A Foekens Hendrik G Stunnenberg Laura van't Veer Douglas F Easton Paul T Spellman Sancha Martin Anna D Barker Lynda Chin Francis S Collins Carolyn C Compton Martin L Ferguson Daniela S Gerhard Gad Getz Chris Gunter Alan Guttmacher Mark Guyer D Neil Hayes Eric S Lander Brad Ozenberger Robert Penny Jane Peterson Chris Sander Kenna M Shaw Terence P Speed Paul T Spellman Joseph G Vockley David A Wheeler Richard K Wilson Thomas J Hudson Lynda Chin Bartha M Knoppers Eric S Lander Peter Lichter Lincoln D Stein Michael R Stratton Warwick Anderson Anna D Barker Cindy Bell Martin Bobrow Wylie Burke Francis S Collins Carolyn C Compton Ronald A DePinho Douglas F Easton P Andrew Futreal Daniela S Gerhard Anthony R Green Mark Guyer Stanley R Hamilton Tim J Hubbard Olli P Kallioniemi Karen L Kennedy Timothy J Ley Edison T Liu Youyong Lu Partha Majumder Marco Marra Brad Ozenberger Jane Peterson Alan J Schafer Paul T Spellman Hendrik G Stunnenberg Brandon J Wainwright Richard K Wilson Huanming Yang

Nature 2010 Apr;464(7291):993-8

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http://dx.doi.org/10.1038/nature08987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902243PMC
April 2010

IPO-38 is identified as a novel serum biomarker of gastric cancer based on clinical proteomics technology.

J Proteome Res 2008 Sep 5;7(9):3668-77. Epub 2008 Aug 5.

Department of Surgery of Ruijin Hospital, Shanghai Institute of Digestive Surgery, Shanghai Jiaotong University, 197 Ruijin second Road, Shanghai, 200025, P.R. China.

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http://dx.doi.org/10.1021/pr700638kDOI Listing
September 2008

Increase in the expression of matrix metalloproteinase-12 in the airways of rats with allergic bronchial asthma.

Biol Pharm Bull 2007 Feb;30(2):318-23

Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.

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http://dx.doi.org/10.1248/bpb.30.318DOI Listing
February 2007

Identification of a new target region by loss of heterozygosity at 5p15.33 in sporadic gastric carcinomas: genotype and phenotype related.

Cancer Lett 2005 Jun 26;224(2):329-37. Epub 2005 Jan 26.

Health Science Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Second Medical University, Shanghai 200025, People's Republic of China.

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http://linkinghub.elsevier.com/retrieve/pii/S030438350400911
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http://dx.doi.org/10.1016/j.canlet.2004.11.057DOI Listing
June 2005

Effects of repeated antigen exposure on endothelin-1-induced bronchial smooth muscle contraction and activation of RhoA in sensitized rats.

J Biochem 2005 Jun;137(6):751-6

Department of Pharmacology, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.

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http://dx.doi.org/10.1093/jb/mvi091DOI Listing
June 2005