Publications by authors named "Yingxin Guo"

4 Publications

  • Page 1 of 1

Genome wide association study of the whiteness and colour related traits of flour and dough sheets in common wheat.

Sci Rep 2021 Apr 22;11(1):8790. Epub 2021 Apr 22.

State Key Laboratory of Crop Biology, Key Laboratory of Crop Biology of Shandong Province, Group of Wheat Quality and Molecular Breeding, College of Agronomy, Shandong Agricultural University, Tai'an, 271000, Shandong, People's Republic of China.

Flour whiteness and colour are important factors that influence the quality of wheat flour and end-use products. In this study, a genome wide association study focusing on flour and dough sheet colour using a high density genetic map constructed with 90K single nucleotide polymorphism arrays in a panel of 205 elite winter wheat accessions was conducted in two different locations in 2 years. Eighty-six significant marker-trait associations (MTAs) were detected for flour whiteness and the brightness index (L* value), the redness index (a* value), and the yellowness index (b* value) of flour and dough sheets (P < 10) on homologous group 1, 2, 5 and 7, and chromosomes 3A, 3B, 4A, 6A and 6B. Four, three, eleven, eleven MTAs for the flour whiteness, L* value, a* value, b* value, and one MTA for the dough sheet L* value were identified in more than one environment. Based on MATs, some important new candidate genes were identified. Of these, two candidate genes, TraesCS5D01G004300 and Gsp-1D, for BS00000020_51 were found in wheat, relating to grain hardness. Other candidate genes were associated with proteins, the fatty acid biosynthetic process, the ketone body biosynthetic process, etc.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-021-88241-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062544PMC
April 2021

Two-Dimensional Asynchronous Sliding-Mode Control of Markov Jump Roesser Systems.

IEEE Trans Cybern 2020 Jul 28;PP. Epub 2020 Jul 28.

In this article, asynchronous sliding-mode control (SMC) is investigated for 2-D discrete-time Markov jump systems. As the system modes are not always accessible to the controller, the hidden Markov model is employed to describe the asynchronization between the system modes and controller. A new 2-D sliding surface is constructed and the corresponding asynchronous SMC law is designed under the framework of the hidden Markov model. By Lyapunov function and linear matrix inequality (LMI) approaches, the reachability of system dynamics to the predefined sliding surface is investigated, and sufficient conditions are established to guarantee that the underlying 2-D system is asymptotically mean-square stable (AMSS) with an H∞ disturbance attenuation performance. Then, an algorithm is provided to derive the asynchronous 2D-SMC law. Finally, an example is given to verify the validity and effectiveness of the new SMC law design algorithm.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1109/TCYB.2020.3006329DOI Listing
July 2020

Preparation and pharmacokinetics evaluation of oral self-emulsifying system for poorly water-soluble drug Lornoxicam.

Drug Deliv 2015 13;22(4):487-98. Epub 2014 Feb 13.

Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University , Shenyang , China and.

The present work was performed aiming to develop a new solid self-emulsifying system (SMEDDS) for poorly water-soluble drug Lornoxicam and evaluate the bioavailability in Wister rats by oral gavage. Liquid SMEDDS of Lornoxicam was formulated with Labrafil M 1944 CS as oil phase, Kolliphor HS 15 as a surfactant and Transcutol HP as a cosurfactant after screening various vehicles. The microemulsion system selected from the phase diagram and optimized by central composite design (CCD) response surface method was transformed into solid-SMEDDS (S-SMEDDS) by lyophilization using sucrose as cryoprotectant. The formulations were further characterized by the particle size, poly dispersity index (PDI), self-emulsifying time, zeta potential, transmission electron microscope (TEM), differential scanning calorimeter (DSC), in vitro drug release and in vivo pharmacokinetics. Results of DSC studies confirmed that the drug was incorporated in the S-SMEDDS. The in vitro drug release from Lornoxicam SMEDDS was found to be greatly higher in comparison with that from the commercial tablets. It was indicated that SMEDDS might be effective in reducing the effect of pH variability of Lornoxicam and improving the release performance of Lornoxicam. HPLC system was applied to study the concentration of Lornoxicam in the plasma of the Wister rats after oral administration of Lornoxicam SMEDDS and Lornoxicam commercial tablets. The pharmacokinetics parameters of the rats were C(max) 1065.91 ± 224.90 and 1855.22 ± 748.25 ngmL(-1), T(max) were 2.5 ± 0.4 h and 1.8 ± 0.5 h, and AUC(0∼t) were 5316.35 ± 323.62 and 7758.07 ± 241.57 ngmL(-1) h, respectively. Calculated by AUC(0∼∞), the relative bioavailability of Lornoxicam S-SMEDDS was 151.69 ± 15.32%. It suggested that this S-SMEDDS could be used as a successful oral solid dosage form to improve the solubility and bioavailability of poorly water-soluble drug Lornoxicam as well.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3109/10717544.2014.885615DOI Listing
March 2016

Effects of natural and recombinant hirudin on VEGF expression and random skin flap survival in a venous congested rat model.

Int Surg 2013 Jan-Mar;98(1):82-7

Department of Plastic and Aesthetic Surgery, the first Affiliated Hospital of Guangxi Medical University, Nanning Guangxi, People's Republic of China.

We aim to investigate the effects of locally injected natural and recombinant hirudin on vascular endothelial growth factor (VEGF) expression and flap survival in venous congested skin flaps using a rat model. A dorsal random skin flap (10 × 3 cm) was prepared on each of 30 Wistar rats to establish a venous congested model. The rats were randomly divided into 2 treatment groups [receiving subcutaneous injection of either natural hirudin (6 U) or recombinant hirudin (6 U)] and a control group, which received subcutaneous injection of physiologic saline. After treatment, skin flap survival rates were calculated. VEGF messenger RNA levels and VEGF-positive vessel density as a marker for VEGF levels were measured in the flaps during and after treatment. The skin flap VEGF messenger RNA levels increased in the natural hirudin-treated group. The VEGF-positive vessel density was increased in all 3 groups. Statistically significant increases of VEGF levels were observed in the natural and recombinant hirudin-treated groups compared with the control group (P < 0.05). The skin flap survival rates were improved in both hirudin treated groups. Natural and recombinant hirudin can increase VEGF expression in random skin flaps, which can potentially improve random skin flap survival in rats through angio genic mechanisms. Our results showed that hirudin treatment led to an increase in VEGF expression in the congested skin flaps. Natural hirudin demonstrated more pronounced effects than recombinant hirudin. Further studies are needed to understand the specific mechanisms.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.9738/CC171.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723165PMC
August 2014
-->