Yingxiao Wang

Yingxiao Wang

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Yingxiao Wang

Publications by authors named "Yingxiao Wang"

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An AND-Gated Drug and Photoactivatable Cre- System for Spatiotemporal Control in Cell-Based Therapeutics.

ACS Synth Biol 2019 Oct 8. Epub 2019 Oct 8.

Department of Pathology, Veterans Affairs San Diego Healthcare System , University of California, San Diego , 9500 Gilman Drive , La Jolla , California 92093-0412 , United States.

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http://dx.doi.org/10.1021/acssynbio.9b00175DOI Listing
October 2019

Genetically Encoded FRET Biosensor for Visualizing EphA4 Activity in Different Compartments of the Plasma Membrane.

ACS Sens 2019 Feb 16;4(2):294-300. Epub 2019 Jan 16.

Sanford Burnham Prebys Medical Discovery Institute , La Jolla , California 92037 , United States.

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http://dx.doi.org/10.1021/acssensors.8b00465DOI Listing
February 2019

Protein circuits reprogram cells.

Nat Chem Biol 2019 02;15(2):96-97

Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/s41589-018-0210-5DOI Listing
February 2019

Matrix Rigidity-Dependent Regulation of Ca at Plasma Membrane Microdomains by FAK Visualized by Fluorescence Resonance Energy Transfer.

Adv Sci (Weinh) 2019 Feb 18;6(4):1801290. Epub 2018 Dec 18.

Neuroscience Program and the Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign Urbana IL 61801 USA.

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http://dx.doi.org/10.1002/advs.201801290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382294PMC
February 2019

Sensitive FRET Biosensor Reveals Fyn Kinase Regulation by Submembrane Localization.

ACS Sens 2019 01 9;4(1):76-86. Epub 2019 Jan 9.

Department of Bioengineering , University of California at San Diego , La Jolla , California 92093 , United States.

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http://pubs.acs.org/doi/10.1021/acssensors.8b00896
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http://dx.doi.org/10.1021/acssensors.8b00896DOI Listing
January 2019

Pathological cyclic strain promotes proliferation of vascular smooth muscle cells via the ACTH/ERK/STAT3 pathway.

J Cell Biochem 2018 11 26;119(10):8260-8270. Epub 2018 Jun 26.

Institute of Mechanobiology and Medical Engineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.

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http://dx.doi.org/10.1002/jcb.26839DOI Listing
November 2018

Deciphering and engineering chromodomain-methyllysine peptide recognition.

Sci Adv 2018 11 7;4(11):eaau1447. Epub 2018 Nov 7.

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1126/sciadv.aau1447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221542PMC
November 2018

Acoustic mechanogenetics.

Curr Opin Biomed Eng 2018 Sep 11;7:64-70. Epub 2018 Oct 11.

Department of Bioengineering, University of California, San Diego.

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http://dx.doi.org/10.1016/j.cobme.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261469PMC
September 2018

Visualizing Spatiotemporal Dynamics of Intercellular Mechanotransmission upon Wounding.

ACS Photonics 2018 Sep 20;5(9):3565-3574. Epub 2018 Aug 20.

Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, United States.

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http://dx.doi.org/10.1021/acsphotonics.8b00383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502247PMC
September 2018

Directed Evolution to Engineer Monobody for FRET Biosensor Assembly and Imaging at Live-Cell Surface.

Cell Chem Biol 2018 04 27;25(4):370-379.e4. Epub 2018 Jan 27.

Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910193PMC
April 2018

Mechanogenetics for the remote and noninvasive control of cancer immunotherapy.

Proc Natl Acad Sci U S A 2018 01 17;115(5):992-997. Epub 2018 Jan 17.

Department of Bioengineering & Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093;

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http://dx.doi.org/10.1073/pnas.1714900115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798350PMC
January 2018

Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions.

Nat Commun 2017 09 7;8(1):477. Epub 2017 Sep 7.

Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

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http://dx.doi.org/10.1038/s41467-017-00569-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589908PMC
September 2017

Subcellular domain-dependent molecular hierarchy of SFK and FAK in mechanotransduction and cytokine signaling.

Sci Rep 2017 08 22;7(1):9033. Epub 2017 Aug 22.

Department of Biomedical Engineering, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, 46202, USA.

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http://www.nature.com/articles/s41598-017-09495-5
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http://dx.doi.org/10.1038/s41598-017-09495-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567257PMC
August 2017

Acoustic-transfection for genomic manipulation of single-cells using high frequency ultrasound.

Sci Rep 2017 07 13;7(1):5275. Epub 2017 Jul 13.

Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, Los Angeles, California, 90089, USA.

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http://dx.doi.org/10.1038/s41598-017-05722-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509725PMC
July 2017

FRET-based Visualization of PDGF Receptor Activation at Membrane Microdomains.

Sci Rep 2017 05 9;7(1):1593. Epub 2017 May 9.

Neuroscience Program, University of Illinois, Urbana-Champaign, Urbana, IL, 61801, USA.

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http://dx.doi.org/10.1038/s41598-017-01789-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431615PMC
May 2017

Involvement of a Rac1-Dependent Macropinocytosis Pathway in Plasmid DNA Delivery by Electrotransfection.

Mol Ther 2017 03 24;25(3):803-815. Epub 2017 Jan 24.

Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA; Department of Ophthalmology, Duke University, Durham, NC 27708, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2016.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363188PMC
March 2017

Imaging Spatiotemporal Activities of ZAP-70 in Live T Cells Using a FRET-Based Biosensor.

Ann Biomed Eng 2016 12 6;44(12):3510-3521. Epub 2016 Jul 6.

Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

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http://dx.doi.org/10.1007/s10439-016-1683-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114152PMC
December 2016

In-situ coupling between kinase activities and protein dynamics within single focal adhesions.

Sci Rep 2016 07 7;6:29377. Epub 2016 Jul 7.

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1038/srep29377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935953PMC
July 2016

Nuclear envelope proteins modulate proliferation of vascular smooth muscle cells during cyclic stretch application.

Proc Natl Acad Sci U S A 2016 May 25;113(19):5293-8. Epub 2016 Apr 25.

Institute of Mechanobiology and Medical Engineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China;

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http://dx.doi.org/10.1073/pnas.1604569113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868428PMC
May 2016

Rapid and Localized Mechanical Stimulation and Adhesion Assay: TRPM7 Involvement in Calcium Signaling and Cell Adhesion.

PLoS One 2015 6;10(5):e0126440. Epub 2015 May 6.

Department of Bioengineering & Beckman Institute for Advanced Science and Technology, Center for Biophysics and Computational Biology, Institute for Genomic Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois, 61801, United States of America; Department of Mechanical Science & Engineering, Integrative and Molecular Physiology, Center for Biophysics and Computational Biology, Institute for Genomic Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois, 61801, United States of America; Department of Bioengineering & Institute of Engineering in Medicine, University of California, San Diego, La Jolla, California, 92093, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126440PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422584PMC
April 2016

New technologies of molecular engineering and screening for cell signaling studies.

Authors:
Yingxiao Wang

Mol Biol Cell 2016 Mar;27(6):875-6

Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093

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http://dx.doi.org/10.1091/mbc.E15-11-0762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791127PMC
March 2016

Real-Time Analysis of Calcium Signals during the Early Phase of T Cell Activation Using a Genetically Encoded Calcium Biosensor.

J Immunol 2016 Feb 8;196(4):1471-9. Epub 2016 Jan 8.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110; Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110;

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http://www.jimmunol.org/content/early/2016/01/07/jimmunol.15
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1502414
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http://dx.doi.org/10.4049/jimmunol.1502414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744592PMC
February 2016

Direct and sustained intracellular delivery of exogenous molecules using acoustic-transfection with high frequency ultrasound.

Sci Rep 2016 Feb 4;6:20477. Epub 2016 Feb 4.

Department of Biomedical Engineering, University of Southern California, Los Angeles, California 90089, USA.

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http://dx.doi.org/10.1038/srep20477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740885PMC
February 2016

The availability and affordability of orphan drugs for rare diseases in China.

Orphanet J Rare Dis 2016 Feb 27;11:20. Epub 2016 Feb 27.

Department of Endocrinology, Institute of Geriatric medicine, Liyuan Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.

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http://dx.doi.org/10.1186/s13023-016-0392-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769558PMC
February 2016

Integrin Molecular Tension within Motile Focal Adhesions.

Biophys J 2015 Dec;109(11):2259-67

Department of Physics and Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Urbana, Illinois; Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois; Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, Maryland; Department of Biophysics & Biophysical Chemistry, Department of Biophysics, and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.bpj.2015.10.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675889PMC
December 2015

Activatable and Cell-Penetrable Multiplex FRET Nanosensor for Profiling MT1-MMP Activity in Single Cancer Cells.

Nano Lett 2015 Aug 27;15(8):5025-32. Epub 2015 Jul 27.

§Department of Bioengineering, University of Illinois at Urbana-Champaign, Champaign, Illinois 61801, United States.

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http://dx.doi.org/10.1021/acs.nanolett.5b01047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675668PMC
August 2015

Subcellular and Dynamic Coordination between Src Activity and Cell Protrusion in Microenvironment.

Sci Rep 2015 Aug 11;5:12963. Epub 2015 Aug 11.

1] Department of Bioengineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801 [2] Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093-0435.

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http://dx.doi.org/10.1038/srep12963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531316PMC
August 2015

Prolonged mechanical stretch initiates intracellular calcium oscillations in human mesenchymal stem cells.

PLoS One 2014 20;9(10):e109378. Epub 2014 Oct 20.

Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America; Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America; Department of Bioengineering and Institute of Engineering in Medicine, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109378PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203723PMC
July 2015

The primary cilium functions as a mechanical and calcium signaling nexus.

Cilia 2015 29;4. Epub 2015 May 29.

Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, MC 8904, 1210 Amsterdam Ave, New York, NY 10027 USA.

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http://dx.doi.org/10.1186/s13630-015-0016-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448211PMC
June 2015

Nuclear envelope proteins Nesprin2 and LaminA regulate proliferation and apoptosis of vascular endothelial cells in response to shear stress.

Biochim Biophys Acta 2015 May 23;1853(5):1165-73. Epub 2015 Feb 23.

Institute of Mechanobiology & Medical Engineering, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2015.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784407PMC
May 2015

Single-cell imaging of mechanotransduction in endothelial cells.

Prog Mol Biol Transl Sci 2014 ;126:25-51

Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1016/B978-0-12-394624-9.00002-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665391PMC
April 2015

Laser-induced shockwave paired with FRET: a method to study cell signaling.

Microsc Res Tech 2015 Mar 13;78(3):195-9. Epub 2015 Jan 13.

Institute of Engineering in Medicine, University of California, San Diego 9500, Gilman Drive La Jolla, California, 92093-0435.

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http://dx.doi.org/10.1002/jemt.22463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675664PMC
March 2015

Mechanical loading in osteocytes induces formation of a Src/Pyk2/MBD2 complex that suppresses anabolic gene expression.

PLoS One 2014 19;9(5):e97942. Epub 2014 May 19.

Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097942PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026426PMC
January 2015

Dynamic visualization of α-catenin reveals rapid, reversible conformation switching between tension states.

Curr Biol 2015 Jan 24;25(2):218-224. Epub 2014 Dec 24.

Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Department of Bioengineering and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Department of Integrative and Molecular Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Department of Bioengineering and Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302114PMC
January 2015

Nanoporous silica-based protocells at multiple scales for designs of life and nanomedicine.

Life (Basel) 2015 Jan 19;5(1):214-29. Epub 2015 Jan 19.

Department of Chemical and Nuclear Engineering, Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NW 87106, USA.

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http://dx.doi.org/10.3390/life5010214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390849PMC
January 2015

Photocaged DNAzymes as a general method for sensing metal ions in living cells.

Angew Chem Int Ed Engl 2014 Dec 14;53(50):13798-802. Epub 2014 Oct 14.

Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801 (USA).

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http://dx.doi.org/10.1002/anie.201408333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297208PMC
December 2014

3D traction stresses activate protease-dependent invasion of cancer cells.

Biophys J 2014 Dec 2;107(11):2528-37. Epub 2014 Dec 2.

Department of Bioengineering, University of California-San Diego, La Jolla, California; Institute of Engineering in Medicine, University of California-San Diego, La Jolla, California; IFOM-inStem Joint Research Laboratory, Bangalore, India. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2014.07.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255420PMC
December 2014

RhoA and membrane fluidity mediates the spatially polarized Src/FAK activation in response to shear stress.

Sci Rep 2014 Nov 12;4:7008. Epub 2014 Nov 12.

1] Department of Bioengineering and the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA [2] Department of Integrative and Molecular Physiology, Center for Biophysics and Computational Biology, Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA [3] Department of Bioengineering, University of California at San Diego, CA 92093, USA.

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http://dx.doi.org/10.1038/srep07008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228346PMC
November 2014

Electroporation-delivered fluorescent protein biosensors for probing molecular activities in cells without genetic encoding.

Chem Commun (Camb) 2014 Oct;50(78):11536-9

School of Biomedical Engineering and Sciences, Virginia Tech-Wake Forest University, Blacksburg, Virginia 24061, USA.

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http://dx.doi.org/10.1039/c4cc04730cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783554PMC
October 2014

The regulation of β-adrenergic receptor-mediated PKA activation by substrate stiffness via microtubule dynamics in human MSCs.

Biomaterials 2014 Sep 24;35(29):8348-8356. Epub 2014 Jun 24.

Neuroscience Program, Center for Biophysics and Computational Biology, Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2014.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144871PMC
September 2014

Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression.

Nat Commun 2014 Aug 6;5:4619. Epub 2014 Aug 6.

1] Laboratory for Cell Biomechanics and Regenerative Medicine, Department of Biomedical Engineering, School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China [2] Department of Mechanical Science and Engineering, College of Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.

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http://dx.doi.org/10.1038/ncomms5619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133791PMC
August 2014

FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells.

Sci Rep 2014 Aug 12;4:6024. Epub 2014 Aug 12.

1] Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA [2] Institute of Engineering in Medicine University of California, San Diego, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1038/srep06024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129417PMC
August 2014

Decipher the dynamic coordination between enzymatic activity and structural modulation at focal adhesions in living cells.

Sci Rep 2014 Jul 24;4:5756. Epub 2014 Jul 24.

1] Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093-0435 [2] Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 [3] Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801 [4] Center of Biophysics and Computational Biology, Beckman Institute for Advanced Science and Technology, Department of Molecular and Integrative Physiology and, University of Illinois at Urbana-Champaign, Urbana, IL 61801.

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http://www.nature.com/articles/srep05756
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http://dx.doi.org/10.1038/srep05756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108961PMC
July 2014

The effect of differentiation induction on FAK and Src activity in live HMSCs visualized by FRET.

PLoS One 2013 27;8(8):e72233. Epub 2013 Aug 27.

Biomaterials and Live Cell Imaging Institute, Chongqing University of Science and technology, Chongqing, People's Republic of China ; Beckman Institute for Advanced Science and Technology, Center for Biophysics and Computational Biology, Department of Integrative and Molecular Physiology, Institute for Genomic Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072233PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754985PMC
May 2014

Genetically encoded fluorescent biosensors for live-cell imaging of MT1-MMP protease activity.

Methods Mol Biol 2014 ;1071:163-74

Department of Bioengineering, University of Illinois at Urbana-Champaign, Champaign, IL, USA.

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http://dx.doi.org/10.1007/978-1-62703-622-1_13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550515PMC
April 2014

The role of mechanical tension on lipid raft dependent PDGF-induced TRPC6 activation.

Biomaterials 2014 Mar 4;35(9):2868-77. Epub 2014 Jan 4.

Department of Bioengineering & Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801, United States; Department of Bioengineering & Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, United States. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2013.12.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925146PMC
March 2014

Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2.

Nat Commun 2013 ;4:2037

Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1038/ncomms3037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777412PMC
December 2013

Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins.

Proc Natl Acad Sci U S A 2013 Nov 12;110(48):19372-7. Epub 2013 Nov 12.

Neuroscience Program, Department of Mechanical Science and Engineering, and Department of Bioengineering and Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801.

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http://dx.doi.org/10.1073/pnas.1307405110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845171PMC
November 2013

Special section on fluorescence molecular imaging honoring Prof. Roger Tsien, a pioneer in biomedical optics.

J Biomed Opt 2013 Oct;18(10):101301

Institute for Biological and Medical Imaging, Helmholtz Zentrum München GmbH.

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http://dx.doi.org/10.1117/1.JBO.18.10.101301DOI Listing
October 2013

Quantitative FRET imaging to visualize the invasiveness of live breast cancer cells.

PLoS One 2013 13;8(3):e58569. Epub 2013 Mar 13.

Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058569PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596289PMC
September 2013

Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer.

Cancer Res 2013 Aug 7;73(15):4674-86. Epub 2013 Jun 7.

The Beatson Institute for Cancer Research, Glasgow; Section of Dermatology, School of Medicine, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-4545DOI Listing
August 2013

The antagonistic roles of PDGF and integrin αvβ3 in regulating ROS production at focal adhesions.

Biomaterials 2013 May 7;34(15):3807-15. Epub 2013 Mar 7.

Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2013.01.092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602290PMC
May 2013

Mechanotransduction at focal adhesions: from physiology to cancer development.

J Cell Mol Med 2013 May 18;17(5):597-604. Epub 2013 Apr 18.

Neuroscience Program, University of Illinois, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1111/jcmm.12045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665742PMC
May 2013

Visualization of Src and FAK activity during the differentiation process from HMSCs to osteoblasts.

PLoS One 2012 10;7(8):e42709. Epub 2012 Aug 10.

Biomaterials and Live Cell Imaging Institute, School of Metallurgy and Materials Engineering, Chongqing University of Science and technology, Chongqing, People's Republic of China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416797PMC
March 2013

FRET imaging of calcium signaling in live cells in the microenvironment.

Integr Biol (Camb) 2013 Feb;5(2):431-8

Department of Bioengineering & Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, IL 61801, USA.

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http://dx.doi.org/10.1039/c2ib20264fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165894PMC
February 2013

Dispersion-relation fluorescence spectroscopy.

Phys Rev Lett 2012 Nov 2;109(18):188104. Epub 2012 Nov 2.

Quantitative Light Imaging Laboratory, Department of Mechanical Science and Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.

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http://dx.doi.org/10.1103/PhysRevLett.109.188104DOI Listing
November 2012

VE-cadherin trans-interactions modulate Rac activation and enhancement of lung endothelial barrier by iloprost.

J Cell Physiol 2012 Oct;227(10):3405-16

Lung Injury Center, Section of Pulmonary and Critical Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1002/jcp.24041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328640PMC
October 2012

Calcium signaling in live cells on elastic gels under mechanical vibration at subcellular levels.

PLoS One 2011 28;6(10):e26181. Epub 2011 Oct 28.

Department of Bioengineering and Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026181PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203865PMC
February 2012

Computational analysis of the spatiotemporal coordination of polarized PI3K and Rac1 activities in micro-patterned live cells.

PLoS One 2011 27;6(6):e21293. Epub 2011 Jun 27.

Department of Bioengineering, University of Illinois at Urbana-Champaign, Champaign, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021293PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124492PMC
December 2011

A FRET-Based Biosensor for Imaging SYK Activities in Living Cells.

Cell Mol Bioeng 2011 Dec;4(4):670-677

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.

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http://dx.doi.org/10.1007/s12195-011-0211-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274623PMC
December 2011

Bone Physiology, Biomaterial and the Effect of Mechanical/Physical Microenvironment on MSC Osteogenesis: A Tribute to Shu Chien's 80th Birthday.

Cell Mol Bioeng 2011 Dec;4(4):579-590

Department of Bioengineering & Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801 ; Center for Biophysics and Computational Biology, Department of Integrative and Molecular Physiology, Institute for Genomic Biology, University of Illinois, Urbana-Champaign, Urbana, IL 61801.

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http://dx.doi.org/10.1007/s12195-011-0204-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288028PMC
December 2011

Two distinct phases of calcium signalling under flow.

Cardiovasc Res 2011 Jul 1;91(1):124-33. Epub 2011 Feb 1.

Department of Bioengineering and Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1093/cvr/cvr033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112016PMC
July 2011

Phase differential enhancement of FLIM to distinguish FRET components of a biosensor for monitoring molecular activity of Membrane Type 1 Matrix Metalloproteinase in live cells.

J Fluoresc 2011 Jul 26;21(4):1763-77. Epub 2011 Apr 26.

Center of Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1007/s10895-011-0871-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637990PMC
July 2011

Live Cell Imaging of Src/FAK Signaling by FRET.

Cell Mol Bioeng 2011 Jun;2(4):138-147

Neuroscience Program, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1007/s12195-011-0161-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157646PMC
June 2011

Micro/nano-fabrication technologies for cell biology.

Med Biol Eng Comput 2010 Oct 21;48(10):1023-32. Epub 2010 May 21.

Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1007/s11517-010-0632-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373892PMC
October 2010

Fluorescence resonance energy transfer biosensors for cancer detection and evaluation of drug efficacy.

Clin Cancer Res 2010 Aug;16(15):3822-4

Department of Bioengineering & Beckman Institute for Advanced Science and Technology, Neuroscience Program, Center of Biophysics and Computational Biology, Institute of Genomic Biology, University of Illinois at Urbana-Champaign, 405 N. Mathews Avenue, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913312PMC
August 2010

Live cell imaging of mechanotransduction.

J R Soc Interface 2010 Jun 31;7 Suppl 3:S365-75. Epub 2010 Mar 31.

Department of Bioengineering and Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1098/rsif.2010.0042.focusDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943879PMC
June 2010

Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer.

Cancer Res 2010 Mar 2;70(6):2204-12. Epub 2010 Mar 2.

Department of Bioengineering, Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Illinois 61801, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-3698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840183PMC
March 2010

Rapid activation of Rac GTPase in living cells by force is independent of Src.

PLoS One 2009 Nov 18;4(11):e7886. Epub 2009 Nov 18.

Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007886PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773925PMC
November 2009

FRET and mechanobiology.

Integr Biol (Camb) 2009 Oct;1(10):565-73

Department of Bioengineering, Center for Biophysics and Computational Biology, Institute of Genomic Biology, The Beckman Institute for Advance Science and Technology, University of Illinois at Urbana-Champaign, IL 61801, USA.

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http://dx.doi.org/10.1039/b913093bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794131PMC
October 2009

Shear Stress Regulates the Flk-1/Cbl/PI3K/NF-κB Pathway Via Actin and Tyrosine Kinases.

Cell Mol Bioeng 2009 Sep;2(3):341-350

Department of Bioengineering and The Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1007/s12195-009-0069-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790296PMC
September 2009

Plectin contributes to mechanical properties of living cells.

Am J Physiol Cell Physiol 2009 Apr 25;296(4):C868-77. Epub 2009 Feb 25.

Dept. of Mechanical Science, Univ. of Illinois, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1152/ajpcell.00604.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670656PMC
April 2009

Substrate rigidity regulates Ca2+ oscillation via RhoA pathway in stem cells.

J Cell Physiol 2009 Feb;218(2):285-93

Neuroscience Program, Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, Illinois, USA.

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http://dx.doi.org/10.1002/jcp.21598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592496PMC
February 2009

Differential RhoA dynamics in migratory and stationary cells measured by FRET and automated image analysis.

PLoS One 2008 30;3(12):e4082. Epub 2008 Dec 30.

Center of Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004082PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603592PMC
February 2009

Visualization of Src activity at different compartments of the plasma membrane by FRET imaging.

Chem Biol 2009 Jan;16(1):48-57

Neuroscience Program, Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1016/j.chembiol.2008.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647969PMC
January 2009

Fluorescence proteins, live-cell imaging, and mechanobiology: seeing is believing.

Annu Rev Biomed Eng 2008 ;10:1-38

Department of Bioengineering and Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1146/annurev.bioeng.010308.161731DOI Listing
October 2008

Determination of hierarchical relationship of Src and Rac at subcellular locations with FRET biosensors.

Proc Natl Acad Sci U S A 2008 Sep 17;105(38):14353-8. Epub 2008 Sep 17.

Department of Bioengineering, Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, IL 61801, USA.

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http://dx.doi.org/10.1073/pnas.0807537105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567163PMC
September 2008

The spatiotemporal pattern of Src activation at lipid rafts revealed by diffusion-corrected FRET imaging.

PLoS Comput Biol 2008 Jul 25;4(7):e1000127. Epub 2008 Jul 25.

Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

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http://dx.doi.org/10.1371/journal.pcbi.1000127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517613PMC
July 2008

Visualization of polarized membrane type 1 matrix metalloproteinase activity in live cells by fluorescence resonance energy transfer imaging.

J Biol Chem 2008 Jun 25;283(25):17740-8. Epub 2008 Apr 25.

Department of Bioengineering and the Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Illinois 61801, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M709872200
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http://dx.doi.org/10.1074/jbc.M709872200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427332PMC
June 2008

Rapid signal transduction in living cells is a unique feature of mechanotransduction.

Proc Natl Acad Sci U S A 2008 May 2;105(18):6626-31. Epub 2008 May 2.

Departments of Mechanical Science and Engineering and Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1073/pnas.0711704105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373315PMC
May 2008

Analysis of integrin signaling by fluorescence resonance energy transfer.

Methods Enzymol 2007 ;426:177-201

Department of Bioengineering and Molecular & Integrative Physiology, Neuroscience Program, Center for Biophysics and Computational Biology, Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, USA.

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http://dx.doi.org/10.1016/S0076-6879(07)26009-4DOI Listing
October 2007

Laser tweezers in the study of mechanobiology in live cells.

Methods Cell Biol 2007 ;82:497-523

Department of Biomedical Engineering, Beckman Laser Institute, University of California, Irvine, California 92612, USA.

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http://dx.doi.org/10.1016/S0091-679X(06)82018-2DOI Listing
August 2007

Selective adapter recruitment and differential signaling networks by VEGF vs. shear stress.

Proc Natl Acad Sci U S A 2007 May 11;104(21):8875-9. Epub 2007 May 11.

Department of Bioengineering and The Whitaker Institute of Biomedical Engineering, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.0703088104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885595PMC
May 2007

Roles of microfilaments and microtubules in paxillin dynamics.

Biochem Biophys Res Commun 2006 Oct 14;348(4):1463-71. Epub 2006 Aug 14.

Department of Bioengineering and the Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.bbrc.2006.08.022DOI Listing
October 2006

Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras.

Proc Natl Acad Sci U S A 2006 Feb 30;103(6):1774-9. Epub 2006 Jan 30.

Department of Bioengineering, The Whitaker Institute of Biomedical Engineering, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.0510774103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413667PMC
February 2006

Visualizing the mechanical activation of Src.

Nature 2005 Apr;434(7036):1040-5

Department of Bioengineering and the Whitaker Institute of Biomedical Engineering, La Jolla, California 92093, USA.

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http://www.nature.com/articles/nature03469
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April 2005