Yingjian Liang

Yingjian Liang

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Yingjian Liang

Yingjian Liang

Publications by authors named "Yingjian Liang"

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42Publications

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Gankyrin drives metabolic reprogramming to promote tumorigenesis, metastasis and drug resistance through activating β-catenin/c-Myc signaling in human hepatocellular carcinoma.

Cancer Lett 2019 Feb 29;443:34-46. Epub 2018 Nov 29.

Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, China; Department of Pharmacology (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Heilongjiang Province, Harbin, China; Department of Phase I Clinical Trials, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, China. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.11.030DOI Listing
February 2019

Unfractionated Heparin Alleviates Sepsis-Induced Acute Lung Injury by Protecting Tight Junctions.

J Surg Res 2019 Feb 13;238:175-185. Epub 2019 Feb 13.

Department of Critical Care Medicine, The First Affiliated Hospital, China Medical University, Shenyang, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2019.01.020DOI Listing
February 2019

Tetraspanin 1 promotes epithelial-to-mesenchymal transition and metastasis of cholangiocarcinoma via PI3K/AKT signaling.

J Exp Clin Cancer Res 2018 Dec 4;37(1):300. Epub 2018 Dec 4.

Department of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, Heilongjiang, China.

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http://dx.doi.org/10.1186/s13046-018-0969-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280496PMC
December 2018

Long non-coding RNA NEAT1-modulated abnormal lipolysis via ATGL drives hepatocellular carcinoma proliferation.

Mol Cancer 2018 05 15;17(1):90. Epub 2018 May 15.

Department of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, Heilongjiang Province, China.

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http://dx.doi.org/10.1186/s12943-018-0838-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953401PMC
May 2018

[Unfractionated heparin ameliorates lipopolysaccharide induced expressions of nitric oxide and reactive oxygen species in renal microvascular endothelial cells].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 May;30(5):405-408

Department of Intensive Care Unit, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, China. Corresponding author: Ma Xiaochun, Email:

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.05.003DOI Listing
May 2018

[Unfractionated heparin inhibits the activation of endothelial cells by decreasing the degree of HOXA9 reduced expression].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Apr;30(4):302-305

Department of Critical Care Medicine, the First Hospital of China Medical University, Shenyang 110001, Liaoning, China. Corresponding author: Ma Xiaochun, Email:

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.04.003DOI Listing
April 2018

STK17B promotes carcinogenesis and metastasis via AKT/GSK-3β/Snail signaling in hepatocellular carcinoma.

Cell Death Dis 2018 Feb 14;9(2):236. Epub 2018 Feb 14.

Department of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, China.

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http://dx.doi.org/10.1038/s41419-018-0262-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833726PMC
February 2018

N-myc downstream-regulated gene 2 inhibits human cholangiocarcinoma progression and is regulated by leukemia inhibitory factor/MicroRNA-181c negative feedback pathway.

Hepatology 2016 11 30;64(5):1606-1622. Epub 2016 Sep 30.

Department of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, China.

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http://dx.doi.org/10.1002/hep.28781DOI Listing
November 2016

Inhibition of histone deacetylase 6 restores intestinal tight junction in hemorrhagic shock.

J Trauma Acute Care Surg 2016 09;81(3):512-9

From the Department of Surgical ICU (Z.C.), Beijing Hospital, Beijing, China; Department of Cardiothoracic Surgery (W.H.), Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China; Department of Surgery (Z.C., Y.L., W.H., B.L., I.H., T.B., B.P., Y.L., V.C.N., P.G., H.B.A.), University of Michigan Hospital, Ann Arbor, Michigan; The First Hospital (Y.L.), China Medical University, Shengyang, China; and Department of Pathology (X.D.), Loyola University Medical Center, Maywood, Illinois.

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http://dx.doi.org/10.1097/TA.0000000000001137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001880PMC
September 2016

FCN2 inhibits epithelial-mesenchymal transition-induced metastasis of hepatocellular carcinoma via TGF-β/Smad signaling.

Cancer Lett 2016 08 10;378(2):80-6. Epub 2016 May 10.

Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Department of General Surgery, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.05.007DOI Listing
August 2016

Selecting molecular therapeutic drug targets based on the expression profiles of intrahepatic cholangiocarcinomas and miRNA-mRNA regulatory networks.

Oncol Rep 2016 Jan 15;35(1):382-90. Epub 2015 Oct 15.

Key Laboratory of Hepatosplenic Surgery, Chinese Ministry of Education, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.

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http://dx.doi.org/10.3892/or.2015.4330DOI Listing
January 2016

A preliminary study of ALPPS procedure in a rat model.

Sci Rep 2015 Dec 3;5:17567. Epub 2015 Dec 3.

Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Department of General Surgery, the First Affiliated Hospital of Harbin Medical University, Harbin, China.

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http://dx.doi.org/10.1038/srep17567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668375PMC
December 2015

Selective inhibition of histone deacetylase 6 promotes survival in a rat model of hemorrhagic shock.

J Trauma Acute Care Surg 2015 Dec;79(6):905-10

From the Department of Surgical ICU (Z.C.), Beijing Hospital Ministry of Health, Beijing; Department of Cardiothoracic Surgery (W.H.), Zhongda Hospital, School of Medicine, Southeast University, Nanjing; and The First Hospital (Y.Lia.), China Medical University, Shengyang, China; and Department of Surgery (Z.C., Y.Li., W.H., B.L., I.H., T.B., Y.Lia., H.B.A.), University of Michigan Hospital, Ann Arbor, Michigan.

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http://dx.doi.org/10.1097/TA.0000000000000784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142612PMC
December 2015

YAP is a critical oncogene in human cholangiocarcinoma.

Oncotarget 2015 Jul;6(19):17206-20

Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627302PMC
http://dx.doi.org/10.18632/oncotarget.4043DOI Listing
July 2015

Downregulation of high mobility group box 1 attenuates the severity of acute lung injury in endotoxemic mice.

Mol Med Rep 2015 Jun 26;11(6):4513-7. Epub 2015 Jan 26.

Intensive Care Unit, First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.

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https://www.spandidos-publications.com/10.3892/mmr.2015.3251
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http://dx.doi.org/10.3892/mmr.2015.3251DOI Listing
June 2015

RRAD inhibits the Warburg effect through negative regulation of the NF-κB signaling.

Oncotarget 2015 Jun;6(17):14982-92

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, NJ, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558130PMC
http://dx.doi.org/10.18632/oncotarget.3719DOI Listing
June 2015

GDC-0152 attenuates the malignant progression of osteosarcoma promoted by ANGPTL2 via PI3K/AKT but not p38MAPK signaling pathway.

Int J Oncol 2015 Apr 4;46(4):1651-8. Epub 2015 Feb 4.

Department of Orthopedics, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.

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http://dx.doi.org/10.3892/ijo.2015.2872DOI Listing
April 2015

Reciprocal activation between ATPase inhibitory factor 1 and NF-κB drives hepatocellular carcinoma angiogenesis and metastasis.

Hepatology 2014 Nov 2;60(5):1659-73. Epub 2014 Oct 2.

Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Department of General Surgery, First Affiliated Hospital of Harbin Medical University, Harbin, China.

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http://dx.doi.org/10.1002/hep.27312DOI Listing
November 2014

PTEN antagonises Tcl1/hnRNPK-mediated G6PD pre-mRNA splicing which contributes to hepatocarcinogenesis.

Gut 2014 Oct 18;63(10):1635-47. Epub 2013 Dec 18.

Department of Surgery, Robert-Wood-Johnson Medical School University Hospital, University of Medicine & Dentistry of New Jersey, New Brunswick, New Jersey, USA.

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http://dx.doi.org/10.1136/gutjnl-2013-305302DOI Listing
October 2014

FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling.

BMC Cancer 2014 Oct 25;14:783. Epub 2014 Oct 25.

Department of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, No, 23 Youzheng Street, Heilongjiang Province, Harbin 150001, China.

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http://dx.doi.org/10.1186/1471-2407-14-783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221672PMC
October 2014

The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway.

Oncotarget 2014 Sep;5(18):8478-91

Department of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, Heilongjiang Province, China. Department of Pharmacology (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226698PMC
http://dx.doi.org/10.18632/oncotarget.2328DOI Listing
September 2014

Tumour-associated mutant p53 drives the Warburg effect.

Nat Commun 2013 ;4:2935

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers State University of New Jersey, New Brunswick, New Jersey 08902, USA.

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http://dx.doi.org/10.1038/ncomms3935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969270PMC
July 2014

Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD.

Oncotarget 2014 Jul;5(14):5535-46

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, USA.

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http://www.oncotarget.com/fulltext/2137
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170611PMC
http://dx.doi.org/10.18632/oncotarget.2137DOI Listing
July 2014

Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma.

Mol Cancer 2014 May 31;13:133. Epub 2014 May 31.

Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Department of General Surgery, the First Affiliated Hospital of Harbin Medical University, #23 Youzheng Street, Harbin 150001, Heilongjiang Province, China.

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http://dx.doi.org/10.1186/1476-4598-13-133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046148PMC
May 2014

Gankyrin promotes tumor growth and metastasis through activation of IL-6/STAT3 signaling in human cholangiocarcinoma.

Hepatology 2014 Mar 29;59(3):935-46. Epub 2014 Jan 29.

Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Department of General Surgery, the First Affiliated Hospital of Harbin Medical University, Harbin, China.

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http://dx.doi.org/10.1002/hep.26705DOI Listing
March 2014

[How to understand the diagnosis of VAP correctly].

Zhonghua Yi Xue Za Zhi 2014 Feb;94(5):329-30

Email:

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February 2014

LBH589 Inhibits proliferation and metastasis of hepatocellular carcinoma via inhibition of gankyrin/STAT3/Akt pathway.

Mol Cancer 2013 Oct 5;12(1):114. Epub 2013 Oct 5.

Department of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, 150001 Harbin, Heilongjiang Province, China.

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http://dx.doi.org/10.1186/1476-4598-12-114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853770PMC
October 2013

Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma.

Hepatology 2013 May 14;57(5):1847-57. Epub 2013 Mar 14.

Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Department of General Surgery, the First Affiliated Hospital of Harbin Medical University, Harbin, China.

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http://dx.doi.org/10.1002/hep.26224DOI Listing
May 2013

In vivo and in vitro suppression of hepatocellular carcinoma by EF24, a curcumin analog.

PLoS One 2012 31;7(10):e48075. Epub 2012 Oct 31.

Department of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, Heilongjiang Province, PR China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048075PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485291PMC
April 2013

The regulation of cellular metabolism by tumor suppressor p53.

Cell Biosci 2013 Feb 6;3(1). Epub 2013 Feb 6.

The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, 195 Little Albany Street, New Brunswick, NJ, 08903, USA.

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http://dx.doi.org/10.1186/2045-3701-3-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573943PMC
February 2013

R-SNARE ykt6 resides in membrane-associated protease-resistant protein particles and modulates cell cycle progression when over-expressed.

Biol Cell 2012 Jul 29;104(7):397-417. Epub 2012 May 29.

Division of Biological Sciences and Centre for Structural and Functional Neuroscience, The University of Montana, Missoula, MT 59812, USA.

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http://dx.doi.org/10.1111/boc.201100048DOI Listing
July 2012

Diphenyl difluoroketone: a potent chemotherapy candidate for human hepatocellular carcinoma.

PLoS One 2011 25;6(8):e23908. Epub 2011 Aug 25.

Key Laboratory of Hepatosplenic Surgery, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Ministry of Education, Harbin, Heilongjiang Province, People's Republic of China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023908PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162018PMC
April 2012

PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice.

J Cell Biochem 2010 Sep;111(1):218-28

Department of General Surgery, the First Affiliated Hospital of Harbin Medical University, Harbin, China.

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http://dx.doi.org/10.1002/jcb.22691DOI Listing
September 2010

SNARE status regulates tether recruitment and function in homotypic COPII vesicle fusion.

J Biol Chem 2006 Dec 12;281(50):38825-33. Epub 2006 Oct 12.

Division of Biological Sciences, University of Montana, Missoula, MT 59812-4824, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M606044200
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http://dx.doi.org/10.1074/jbc.M606044200DOI Listing
December 2006

Phospholipase D2 modulates agonist-induced mu-opioid receptor desensitization and resensitization.

J Neurochem 2004 Feb;88(3):680-8

Department of Pharmacology and Toxicology, Otto-von-Guericke University, Magdeburg, Germany.

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February 2004

ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis.

J Biol Chem 2003 Mar 7;278(11):9979-85. Epub 2003 Jan 7.

Department of Pharmacology and Toxicology, Otto-von-Guericke University, 39120 Magdeburg, Germany.

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http://dx.doi.org/10.1074/jbc.M206709200DOI Listing
March 2003