Publications by authors named "Ying Guo"

1,284 Publications

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Genesis and influencing factors of the colour of chrysoprase.

Sci Rep 2021 May 11;11(1):9939. Epub 2021 May 11.

School of Gemmology, China University of Geosciences (Beijing), No.29 Xueyuan Road, Beijing, 100083, China.

The genesis and influencing factors of the colour of chrysoprase were studied based on the results of transmission electron microscopy and X-ray fluorescence, ultraviolet-visible and Raman spectroscopies. The results show that under a 6504-K fluorescent lamp, chrysoprase colour is divided into the grades of fancy, fancy intense and fancy deep. The lightness of chrysoprase is affected mainly by its chromium content, the chroma is affected by its nickel content and the hue angle is affected by the sum of its chromium and ferrum contents. The colour of chrysoprase is related significantly to the transmission window that occurs between the two main bands centred at 380 and 660 nm and the absorption peaks at 380 and 660 nm in the ultraviolet-visible spectrum. Chrysoprase with low crystallinity has more nickel and a higher chroma. The inclusions that cause the chrysoprase colour have been identified as pimelite.
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http://dx.doi.org/10.1038/s41598-021-89406-xDOI Listing
May 2021

The impact of trace metal cations and absorbed water on colour transition of turquoise.

R Soc Open Sci 2021 Feb 3;8(2):201110. Epub 2021 Feb 3.

School of Gemmology, China University of Geosciences (Beijing), Beijing 100083, People's Republic of China.

Thirty-five gem-quality turquoise samples with various colours were investigated using energy-dispersive X-ray fluorescence spectroscopy, ultraviolet-visible spectroscopy, Fourier-transform infrared spectroscopy and scanning electron microscopy. Sample chemical and spectral analyses indicate that Fe contributes to green hue of turquoise, whose absorption band exhibits a bathochromic shift from 426 to 428 nm with increasing V content in the solid-solution series turquoise-chalcosiderite. V enhances absorption in the blue and orange regions, and Cr increases absorption in the green region, both of which are responsible for the vivid greenish yellow in faustite. Substitutions of Al by medium-sized trivalent cations (primarily Fe and V) enhance polarity of the phosphate group (PO), resulting in strong absorption in the infrared spectra for analogues of turquoise. The reflectivity ratio () of the double absorption peaks at 781 and 833 cm allows faustite to be distinguished from turquoise and chalcosiderite, with a value greater than 1, while V-rich faustite only has a single absorption peak at 798 cm. An increasing amount of absorbed water contributes to blue chroma in turquoise and has a negative effect on lightness based on the CIE 1976 *** colour system. Loose turquoise with a low specific gravity tends to display greater colour differences with a significant decrease in lightness.
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http://dx.doi.org/10.1098/rsos.201110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074670PMC
February 2021

Nanocellulose-derived carbon/g-CN heterojunction with a hybrid electron transfer pathway for highly photocatalytic hydrogen peroxide production.

J Colloid Interface Sci 2021 Apr 24;599:507-518. Epub 2021 Apr 24.

College of Material Engineering, Fujian Agriculture and Forestry University, Fuzhou 350108, China.

Using oxygen reduction for the photocatalytic production of hydrogen peroxide (HO) has been considered a green and sustainable route. In the present study, to achieve high efficiency, graphitic carbon nitride (g-CN) was obtained using thermal polymerization from a bi-component precursor and was then assembled with cellulose nanofibers. It was found that a small quantity of cellulose nanofibers that generates carbon fibers upon pyrolysis greatly improves the photocatalytic activity compared with that of g-CN alone. The well-defined carbon/g-CN heterojunction-type material exhibits as high as 1.10 mmol Lh of photo-production of HO under visible light, which is 4.2 times higher than that yielded by pristine g-CN from a single precursor. A comprehensive characterization of the photocatalyst enables us to delineate the effect of the carbon nanofiber with respect to porosity, electron-hole separation, band gap regulation, and especially the electron transfer pathway. Our results demonstrate that nanocellulose-derived carbon, when precisely assembled with other functional material such as a photocatalyst, is a promising promoter of their activity.
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http://dx.doi.org/10.1016/j.jcis.2021.04.111DOI Listing
April 2021

Ultraeven Mo-Doped CoP Nanocrystals as Bifunctional Electrocatalyst for Efficient Overall Water Splitting.

Langmuir 2021 May 7. Epub 2021 May 7.

Laboratory for Low Dimensional Materials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.

To develop precious-metal-free bifunctional catalysts for overall water splitting, ultraeven Mo-doped CoP composites (Mo-CoP) have been fabricated by an in situ phosphorization protocol using CoMo-layered double hydroxide (CoMo-LDH) as the precursor. The ordered arrangement of cations in the CoMo-LDH could be easily phosphored and generate the ultraevenly dispersed Mo element within the CoP structure, resulting in the excellent bifunctional catalyst for overall water splitting. The hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) catalytic activities of the composites present an increase first and then a decreasing tendency with increased Mo doping content. Among all the Mo-doped CoP materials, the composite with a Mo/Co mole ratio of 1/2.3 presents the highest HER activity and stability in acidic conditions. At the current density of -10 mA·cm in 0.5 M HSO, the overpotential is only 116 mV. In addition, the composite also presents excellent HER and OER performance under alkaline conditions. The overpotential is 118 mV for HER and 317 mV for OER at 10 mA cm in 1 M KOH. It requires a cell voltage of 1.7 V to achieve a current density of 10 mA·cm and maintains a stable water-splitting current for at least 24 h, which is superior to most reported alkaline media. This simple and efficient synthetic approach could also be used for ultraeven doping between other transition metal ions.
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http://dx.doi.org/10.1021/acs.langmuir.1c00524DOI Listing
May 2021

Single-Cell Profiling of Kidney Transplant Recipients With Immunosuppressive Treatment Reveals the Dynamic Immune Characteristics.

Front Immunol 2021 20;12:639942. Epub 2021 Apr 20.

Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Kidney transplantation is currently the first choice of treatment for various types of end-stage renal failure, but there are major limitations in the application of immunosuppressive protocols after kidney transplantation. When the dose of immunosuppressant is too low, graft rejection occurs easily, while a dose that is too high can lead to graft loss. Therefore, it is very important to explore the immune status of patients receiving immunosuppressive agents after kidney transplantation. To compare the immune status of the recipient's whole peripheral blood before and after receipt of immunosuppressive agents, we used single-cell cytometry by time-of-flight (CyTOF) to detect the peripheral blood immune cells in five kidney transplant recipients (KTRs) from the Department of Organ Transplantation of Zhujiang Hospital of Southern Medical University before and after receiving immunosuppressive agents. Based on CyTOF analysis, we detected 363,342 live single immune cells. We found that the immune cell types of the KTRs before and after receipt of immunosuppressive agents were mainly divided into CD4+ T cells, CD8+ T cells, B cells, NK cells/γδ T cells, monocytes/macrophages, granulocytes, and dendritic cells (DCs). After further reclustering of the above cell types, it was found that the immune cell subclusters in the peripheral blood of patients underwent major changes after receipt of immunosuppressants. After receiving immunosuppressive therapy, the peripheral blood of KTRs had significantly increased levels of CD57+NK cells and significantly decreased levels of central memory CD4+ T cells, follicular helper CD4+ T cells, effector CD8+ T cells, effector memory CD8+ T cells and naive CD8+ T cells. This study used CyTOF to classify immune cells in the peripheral blood of KTRs before and after immunosuppressive treatment, further compared differences in the proportions of the main immune cell types and immune cell subgroups before and after receipt of immunosuppressants, and provided relatively accurate information for assessment and treatment strategies for KTRs.
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http://dx.doi.org/10.3389/fimmu.2021.639942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093626PMC
April 2021

New Genotype of Found in Live Rodents in Yunnan Province, China.

Front Microbiol 2021 15;12:628335. Epub 2021 Apr 15.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.

Yunnan Province, China is thought to be the original source of biovar Orientalis of , the causative agent of the third plague pandemic that has spread globally since the end of the 19th century. Although encompassing a large area of natural plague foci, strains have rarely been found in live rodents during surveillance in Yunnan, and most isolates are from rodent corpses and their fleas. In 2017, 10 strains were isolated from seven live rodents and three fleas in Heqing County of Yunnan. These strains were supposed to have low virulence to local rodents and because the rodents were healthy and no dead animals were found in surrounding areas, as had occurred in previous epizootic disease. We performed microscopic and biochemical examinations of the isolates, and compared their whole-genome sequences and transcriptome with those of 10 high virulence strains that were isolated from nine rodents and one parasitic flea in adjacent city (Lijiang). We analyzed the phenotypic, genomic, and transcriptomic characteristics of live rodent isolates. The isolates formed a previously undefined monophyletic branch of that was named 1.IN5. Six SNPs, two indels, and one copy number variation were detected between live rodent isolates and the high virulence neighbors. No obvious functional consequence of these variations was found according to the known annotation information. Among genes which expression differential in the live rodent isolates compared to their high virulent neighbors, we found five iron transfer related ones that were significant up-regulated (| log (FC) | > 1, p.adjust < 0.05), indicating these genes may be related to the low-virulence phenotype. The novel genotype of reported here provides further insights into the evolution and spread of plague as well as clues that may help to decipher the virulence mechanism of this notorious pathogen.
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http://dx.doi.org/10.3389/fmicb.2021.628335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084289PMC
April 2021

The Impact of ABCB1 and CES1 Polymorphisms on Dabigatran Pharmacokinetics in Healthy Chinese Subjects.

Pharmgenomics Pers Med 2021 23;14:477-485. Epub 2021 Apr 23.

Internal Medicine-Cardiovascular Department, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing Hospital, Beijing, People's Republic of China.

Dabigatran is a novel direct oral anticoagulant agent, whose plasma concentration is closely related to bleeding risk. Genetic polymorphisms can affect the level of plasma dabigatran. The purpose of this study was to understand the relationship between dabigatran-related genes and the plasma level of dabigatran in healthy Chinese subjects after taking a single oral dose. This study was performed with a single-center, single-dose, randomized, open-label, and four-period crossover trial design under both fasting and fed conditions. A total of 106 eligible healthy subjects were enrolled in the study and 104 were genotyped. One-way analysis of variance (ANOVA) was used to compare pharmacokinetic parameters among different genotypes and linear regression was applied to explore the multiplicative interaction between variables. In this study, we found that the genotype frequencies of CES1 rs2244613 and CES1 rs8192935 were significantly different between Chinese and Caucasians, but the genotype frequencies of ABCB1 rs1045642 and ABCB1 rs4148738 were similar in both populations. CES1 rs8192935 were associated with the peak concentration of dabigatran. There was no significant gender difference in the exposure level of dabigatran. Furthermore, food significantly delayed the absorption of dabigatran but had little effect on C and AUC.
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http://dx.doi.org/10.2147/PGPM.S291723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081719PMC
April 2021

Isolation and characterization of two new chroman-4-ones from the endophytic fungus obtained from Oliver.

Nat Prod Res 2020 Dec 1:1-6. Epub 2020 Dec 1.

Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Two new chroman-4-ones penicichromanone A () and penicichromanone B (), together with three known compounds conioxepinol C (), emodin () and moniliphenone (), were obtained from the endophytic fungus , which was isolated from the bark of Oliver. The structures of and were elucidated by detailed analysis of HRESIMS, 1D/2D NMR and ECD spectra. All the compounds were evaluated for their anti-inflammatory activities using HEK293 cells, and compounds , , and exhibited significant inhibitory effects on TNF--stimulated NF-κB activation.
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http://dx.doi.org/10.1080/14786419.2020.1855161DOI Listing
December 2020

Synergistic Effects of Ladder and Cage Structured Phosphorus-Containing POSS with Tetrabutyl Titanate on Flame Retardancy of Vinyl Epoxy Resins.

Polymers (Basel) 2021 Apr 22;13(9). Epub 2021 Apr 22.

Key Laboratory of Science and Technology on High-Tech Polymer Materials, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

The cage and ladder structured phosphorus-containing polyhedral oligomeric silsesquioxanes (DOPO-POSS) have been synthesized through the hydrolytic condensation of 9,10-dihydro-9-oxa-10-phosphenanthrene-10-oxide (DOPO)-vinyl triethoxysilane (VTES). The unique ladder and cage-ladder structured components in DOPO-POSS endowed it with good solubility in vinyl epoxy resin (VE), and it was used with tetrabutyl titanate (TBT) to construct a phosphorus-silicon-titanium synergy system for the flame retardation of VE. Thermal stabilities, mechanical properties, and flame retardancy of the resultant VE composites were investigated by thermal gravimetric analysis (TGA), dynamic mechanical analysis (DMA), three-point bending tests, limiting oxygen index (LOI) measurement, and cone calorimetry. The experimental results showed that with the addition of only 4 wt% DOPO-POSS and 0.5 wt% TBT, the limiting oxygen index value (LOI) increased from 19.5 of pure VE to 24.2. With the addition of DOPO-POSS and TBT, the peak heat release rate (PHRR), total heat release (THR), smoke production rate (SPR), and total smoke production (TSP) were decreased significantly compared to VE-0. In addition, the VE composites showed improved thermal stabilities and mechanical properties comparable to that of the VE-0. The investigations on pyrolysis volatiles of cured VE further revealed that DOPO-POSS and TBT exerted flame retardant effects in gas phase. The results of char residue of the VE composites by SEM and XPS showed that TBT and DOPO-POSS can accelerate the char formation during the combustion, forming an interior char layer with the honeycomb cavity structure and dense exterior char layer, making the char strong with the formation of Si-O-Ti and Ti-O-P structures.
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http://dx.doi.org/10.3390/polym13091363DOI Listing
April 2021

Salivary microbial diversity at different stages of human immunodeficiency virus infection.

Microb Pathog 2021 Apr 27;155:104913. Epub 2021 Apr 27.

Capital Medical University School of Stomatology, Beijing, 100050, China. Electronic address:

Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) disrupts the host microbial balance. During disease progression, the oral microbial environment is altered in untreated people living with HIV/AIDS (PLWHA); however, no studies have reported changes in salivary microbial diversity during different stages of HIV infection. Therefore, in this study, we aimed to assess the relationships between immune dysfunction and changes in saliva microbiota. To this end, we collected saliva samples from 11 HIV-negative individuals and 44 PLWHA during different stages based on the Centers for Disease Control and Prevention criteria (stage 0, early stage during the first 6 months after infection; stages 1, 2, and 3 associated with CD4 T-lymphocyte counts of ≥500, 200-499, and ≤200 or opportunistic infection, respectively). We analyzed salivary microbial community diversity using polymerase chain reaction amplification and Illumina MiSeq sequencing. We found that HIV-positive individuals had significantly greater alpha-diversity in the microbial community composition compared with HIV-negative controls (P < 0.05) except for AIDS (stage 3); however, the predominant salivary microbiota in the five groups remained similar. Porphyromonas in the four positive groups was the only genus that was significantly less abundant in the HIV-positive groups than in the control group (P < 0.05). There were some consistencies between the general abundance of salivary microbiota and AIDS disease progression. Lots of bacterial abundances in the saliva increased dramatically during the acute HIV infection (stage 0), and some of the negligible and abnormally proliferating bacteria in the asymptomatic stage showed a downward trend. Additionally, in the AIDS stage, partial inhibition was observed. Notably, Porphyromonas was closely related to the immune activation of HIV, showing a decline in abundance once infected with HIV. Solobacterium, which induces inflammation, was negatively correlated with CD4 counts. Overall, our findings provided important insights into changes in salivary microbial diversity in PLWHA.
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http://dx.doi.org/10.1016/j.micpath.2021.104913DOI Listing
April 2021

Application of online-offline integrated medical care management in patients with gestational diabetes.

Ginekol Pol 2021 Apr 29. Epub 2021 Apr 29.

2nd People's Hospital of Lianyungang, Jiangsu Province, China.

Objectives: To investigate efficacy of online-offline integrated medical care management in patients with gestational diabetes.

Material And Methods: A total of 140 patients with gestational diabetes were randomly divided into two groups: integrated management (IM) group (n = 70) and control group (n = 70). Patients in the control group were treated with routine nursing intervention, and the patients in the IM group were treated with integrated care (offline medical and nursing management combined with WeChat online management). The fasting plasma glucose (FPG), 2h postprandial plasma glucose (2hPG), Self-rating Anxiety Scale (SAS) score, Self-rating Depression Scale (SDS) score, Diabetes Care Profile (DPC) score, 36-item Short-Form (SF-36) score, and poor pregnancy outcomes were compared between the two groups.

Results: After intervention, the FPG, 2hPG, SAS score, SDS score, DPC score and SF-36 score were improved in both groups. All indicators in the IM group were better than the control group (p < 0.05). The incidence of premature delivery, polyhydramnios, neonatal respiratory distress, intrauterine distress, and postpartum hemorrhage in the IM group were lower than those in the control group (p < 0.05).

Conclusions: The online-offline integrated medical care management effectively improved the blood glucose level, mental state, self-management behavior, quality of life and pregnancy outcomes of patients with gestational diabetes.
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http://dx.doi.org/10.5603/GP.a2021.0054DOI Listing
April 2021

miR-574-5p mediates epithelial-mesenchymal transition in small cell lung cancer by targeting vimentin via a competitive endogenous RNA network.

Oncol Lett 2021 Jun 8;21(6):459. Epub 2021 Apr 8.

Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, P.R. China.

Numerous studies have suggested that non-coding RNAs mediate tumorigenesis via the epithelial-mesenchymal transition (EMT). However, whether the long non-coding RNA (lncRNA) HOXA transcript at the distal tip (HOTTIP) plays a role in the EMT of small cell lung cancer (SCLC) remains unclear. The results of the present study suggest that HOTTIP-knockdown may lead to a significant increase in E-cadherin expression and a decrease in vimentin (VIM) expression; these proteins are two key markers of EMT. Furthermore, a notable morphological change in SCLC cells with HOTTIP-knockdown was observed: After upregulation of microRNA (miR)-574-5p, the cells exhibited a long, fusiform morphology. Investigating these phenomena further revealed that HOTTIP may participate in EMT by binding to miR-574-5p. In addition, using bioinformatics technology and a dual luciferase reporter assay, it was found that miR-574-5p inhibited VIM expression via direct binding and interaction. In summary, the present results indicate that HOTTIP may be involved in the EMT of SCLC by binding to miR-574-5p, and that miR-574-5p may act through VIM, which is a key marker of EMT.
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http://dx.doi.org/10.3892/ol.2021.12720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063265PMC
June 2021

Functional impairments and rehabilitation outcomes of patients with immunotherapy-induced Acute Inflammatory Demyelinating Polyradiculoneuropathy, Myasthenia Gravis and Myositis.

Am J Phys Med Rehabil 2021 Apr 8. Epub 2021 Apr 8.

The University of Texas MD Anderson Cancer Center, Department of Palliative, Rehabilitation and Integrative Medicine, Houston, Texas.

Abstract: Immunotherapy has led to a higher survival rate among different oncological disease groups but also associated with adverse related events in multiple organ systems. Immunotherapy related musculoskeletal weakness often results in a loss of cancer survivors' physical function, ultimately impacting their independence and quality of life. This is a retrospective study of 24 cancer patients who were treated with immunotherapy either alone or in conjunction with other oncological treatments. Twelve (50%) subjects were found to have acute inflammatory demyelinating polyradiculopathy (AIDP)/Guillain-Barré syndrome (GBS), 6 (25%) myositis, 2 (8%) Myasthenia Gravis (MG) and 2 (8%) diagnosis of myositis/MG and 1 (4%) GBS/MG combination. Physical Therapy (PT) was provided in 91.7% of the cases and Physiatrist was involved in 54% of the cases. Almost half (45%) were discharged home, 6 (25%) to acute inpatient rehabilitation, 2(8%) to subacute rehabilitation, 3 (12.5%) to hospice and 2 (8%) patients died. The average length of hospital stay was 30 days and eight (33%) patients re-admitted within 3 months. Our findings highlight the severity of functional impairments and the need for early rehabilitation interventions.
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http://dx.doi.org/10.1097/PHM.0000000000001764DOI Listing
April 2021

Decreased expression of IDH1 by chronic unpredictable stress suppresses proliferation and accelerates senescence of granulosa cells through ROS activated MAPK signaling pathways.

Free Radic Biol Med 2021 Apr 16;169:122-136. Epub 2021 Apr 16.

The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China; Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, 200030, China; Shanghai Municipal Key Clinical Speciality, Shanghai, 200030, China. Electronic address:

Studies suggested that psychosocial stress was associated with female fertility decline, but the underlying mechanisms remained unclear. Granulosa cells (GCs) are important somatic cells to support follicular development and oocyte maturation. Herein, by using a mouse model of chronic unpredictable stress (CUS), we found that CUS induced oxidative stress damage in mouse ovaries, also inhibited GCs proliferation and accelerated GCs senescence. Isocitrate dehydrogenase-1 (IDH1), an antioxidant related gene by generating NADPH, was shown to be downregulated in GCs of CUS mice. Consistently, IDH1 knockdown inhibited cell proliferation and accelerated cellular senescence in KGN cells in vitro. In addition, IDH1 knockdown increased ROS content, induced autophagy activation and triggered cell cycle arrest in S and G2/M phases in KGN cells, which could be rescued by N-acetyl-l-cysteine (NAC), a ROS scavenger in these cells. Besides, IDH1 knockdown activated MAPK signaling pathways, including ERK, JNK and p38 signaling pathways in KGN cells, while NAC could suppress the activation. Through using inhibitors of MAPK signaling pathways, we showed that the activation of ERK pathway participated in autophagy related cell proliferation inhibition and cellular senescence, whereas JNK and p38 MAPK signaling pathways took part in regulation cell cycle arrest associated cell proliferation inhibitory and senescence in IDH1 knockdown KGN cells. Our findings suggested that downregulated expression of IDH1 induced by CUS has a physiological function in GCs proliferation and senescence through ROS activated MAPK signaling pathways, and improvement of IDH1 activity might be a beneficial therapeutic strategy for ovarian dysfunction.
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http://dx.doi.org/10.1016/j.freeradbiomed.2021.04.016DOI Listing
April 2021

Parabens and bisphenol A and its structural analogues in over-the-counter medicines from China.

Environ Sci Pollut Res Int 2021 Apr 16. Epub 2021 Apr 16.

Guangdong Key Laboratory of Environmental Pollution and Health, and School of Environment, Jinan University, Guangzhou, 510632, China.

Pharmaceuticals, such as over-the-counter (OTC) medicines, may be an important source of human exposure to several endocrine disruptors, though unnoticed to date. In the present study, we investigated the presence of six parabens and nine bisphenol A (BPA) and its analogues in OTC medicines manufactured in China. Parabens and bisphenols were present in more than 90% of the samples. The total measured concentrations of parabens and bisphenols were in the range of non-detectable (ND) to 213 ng/g and ND to 415 ng/g, respectively. Regarding parabens, methyl paraben (MeP) was the predominant analog, accounting for 43 ± 36% of the total amount, followed by ethyl paraben (EtP) (39 ± 35%), and others (< 10%). Bisphenol F and BPA were the predominant bisphenols, accounting for 24 ± 28% and 22 ± 26% of the total amount, respectively. The median values of estimated daily intakes (EDIs) of parabens and bisphenols were the highest for infants (2.96 and 3.14 ng/kg_bw/day, respectively) and the lowest for adults (0.69 and 0.25 ng/kg_bw/day, respectively); moreover, the EDIs of parabens and bisphenols were higher in Chinese patent medicines than in western pediatric medicines. The hazard quotient (HQ) for sum of MeP and EtP (∑(MeP + EtP)) and BPA in three age groups were within the safe zone (HQ < 0.0004). Monte Carlo simulation was applied to predict the human exposure risk of parabens and bisphenols. The predicted ranges of EDIs of parabens and bisphenols were much wider, and the extreme predicted values were observed in all four age groups, which were higher than the acceptable daily intake. The extreme predicted values of ∑(MeP + EtP) and BPA were indicative of carcinogenic risk in toddlers. These results implied potential risks for the Chinese people existed. Considering the huge export of Chinese traditional medicines and western medicines worldwide, and easy access to OTC medicines for the general population, the presence of parabens, bisphenols, and other environmental contaminants in medicines still need to be monitored.
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http://dx.doi.org/10.1007/s11356-021-13931-5DOI Listing
April 2021

Machine-Learning-Guided Discovery and Optimization of Additives in Preparing Cu Catalysts for CO Reduction.

J Am Chem Soc 2021 Apr 12;143(15):5755-5762. Epub 2021 Apr 12.

State Key Laboratory of Physical Chemistry of Solid Surfaces, iChem, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China.

Discovery and optimization of new catalysts can be potentially accelerated by efficient data analysis using machine-learning (ML). In this paper, we record the process of searching for additives in the electrochemical deposition of Cu catalysts for CO reduction (CORR) using ML, which includes three iterative cycles: "experimental test; ML analysis; prediction and redesign". Cu catalysts are known for CORR to obtain a range of products including C (CO, HCOOH, CH, CHOH) and C (CH, CH, CHOH, CHOH). Subtle changes in morphology and surface structure of the catalysts caused by additives in catalyst preparation can lead to dramatic shifts in CORR selectivity. After several ML cycles, we obtained catalysts selective for CO, HCOOH, and C products. This catalyst discovery process highlights the potential of ML to accelerate material development by efficiently extracting information from a limited number of experimental data.
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http://dx.doi.org/10.1021/jacs.1c00339DOI Listing
April 2021

MiR-3663-3p participates in the anti-hepatocellular carcinoma proliferation activity of baicalein by targeting SH3GL1 and negatively regulating EGFR/ERK/NF-κB signaling.

Toxicol Appl Pharmacol 2021 Jun 8;420:115522. Epub 2021 Apr 8.

National & Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, the Second Affiliated Hospital of Xi' an Jiaotong University, Xi'an, Shaanxi 710004, China; Shaanxi Provincial Clinical Research Center for Hepatic & Splenic Diseases, Xi'an, Shaanxi 710004, China; Center for Tumor and Immunology, the Precision Medical Institute, the Second Affiliated Hospital of Xi' an Jiaotong University, Xi'an, Shaanxi 710004, China. Electronic address:

Baicalein is a purified flavonoid that exhibits anticancer effects in hepatocellular carcinoma (HCC). However, its underlying molecular mechanisms remain largely unclear. In this study, we found that baicalein inhibited HCC cell growth, induced apoptosis, and blocked cell cycle arrest at the S phase in vitro, as well as reduced HCC tumor volume and weight in vivo. Quantitative reverse transcriptase-PCR (qRT-PCR) results suggested that miR-3663-3p was downregulated in HCC tissues. After baicalein treatment, miR-3663-3p expression was upregulated in HCC cells. Transfection of miR-3663-3p suppressed HCC cell proliferation and colony formation, increased the proportion of apoptotic cells in vitro, and reduced the volume and weight of tumors in vivo. The results of dual-luciferase reporter assay showed that miR-3663-3p could directly bind to the 3'-UTR of SH3GL1. SH3GL1 overexpression partly reduced the growth-inhibiting effect of miR-3663-3p. Both baicalein treatment and miR-3663-3p overexpression downregulated the expression of SH3GL1 and inactivated the Erk1/2, p-NF-κB/p65, and EGFR signaling pathways. Overall, our data suggest that baicalein may act as a novel HCC suppressor, and that the miR-3663-3p/SH3GL1/EGFR/ERK/NF-κB pathway plays a vital role in HCC progression. Thus, baicalein treatment or miR-3663-3p induction may be a promising strategy for HCC therapy.
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http://dx.doi.org/10.1016/j.taap.2021.115522DOI Listing
June 2021

Exposure to phthalates and correlations with phthalates in dust and air in South China homes.

Sci Total Environ 2021 Mar 31;782:146806. Epub 2021 Mar 31.

Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, School of Environment, Guangzhou 510632, China. Electronic address:

We spend more than half of our daily time in indoor environments, and the contributions of phthalates present in it to total exposure are important. Here, we determined phthalate concentrations in paired indoor settled dust/air and their metabolites in human urine from 100 general families in south China to explore such kind of effect. The total concentrations of phthalates/metabolites were 48.7-2850 μg/g, 279-5080 ng/m and 10.7-2840 ng/mL in the indoor dust, air and urine samples, respectively. Among all targets, di-n-butyl phthalate, di-isobutyl phthalate and di-(2-ethylhexyl) phthalate and their metabolites were the predominant compounds. The daily intakes (DIs) of phthalates via dust or air decreased with age, except for infant, and the values of dust ingestion, air inhalation and air dermal uptake were 2720 ± 2460, 1300 ± 973 and 3590 ± 2890 ng/kg/day for toddlers and 236 ± 194, 360 ± 179 and 1120 ± 586 ng/kg/day for adults, respectively. The ratios of DIs from air to dust were greater than 1.0 for people in all age groups, and the ratio was the highest for adults. Furthermore, the contributions of phthalates from indoor dust and air to total DIs from all sources (estimated from urinary phthalate metabolites) were 0.60%-5.23% and 2.65%-12.2% for different ages, respectively. Our results indicated that indoor air was a quite important source for human exposure to phthalates in indoor environment in south China.
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http://dx.doi.org/10.1016/j.scitotenv.2021.146806DOI Listing
March 2021

Frequency of Sarcopenia, Sarcopenic Obesity, and Changes in Physical Function in Surgical Oncology Patients Referred for Prehabilitation.

Integr Cancer Ther 2021 Jan-Dec;20:15347354211000118

The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Purpose: Sarcopenia and suboptimal performance status are associated with postoperative complications and morbidity in cancer patients. Prehabilitation has emerged as an approach to improve fitness and muscle strength in patients preoperatively. We sought to describe the frequency of sarcopenia and sarcopenic obesity (SO) in a cohort of cancer patients referred for prehabilitation and the association between body composition and physical function.

Methods: In this retrospective review of 99 consecutive cancer patients referred for prehabilitation prior to intended oncologic surgery, prehabilitation included physical medicine and rehabilitation (PM&R) physician evaluation of function and physical therapy for individualized home-based exercise. Sarcopenic A was defined using sex-adjusted norms of skeletal muscle (SKM), measured using the sliceOmatic software (TomoVision, 2012) on computed tomography images at baseline. Sarcopenic B was defined by abnormal SKM and physical function. SO was defined as sarcopenia with BMI ≥ 25. Six-minute walk test (6MWT), 5 times sit-to-stand (5×STS), and grip strength were obtained at consultation (baseline) and at preoperative follow-up (if available).

Results: Forty-nine patients (49%) were Sarcopenic A, 28 (28%) SO, and 38 (38%) Sarcopenic B. Age was negatively correlated with SKM ( = .0436). There were no significant associations between Sarcopenic A/B or SO with baseline or changes in physical function. Assessed by sex, Sarcopenic A females had low 5×STS ( = .04) and Sarcopenic B females had low GS ( = .037). Sarcopenic B males had low preoperative GS ( = .026). 6MWT and grip strength at baseline were lower than age- and sex-related norms (both  < .001). Preoperatively, 6MWT distance and 5×STS time improved (both  < .001). Functional improvement in the sarcopenic and nonsarcopenic patients did not differ according to sex.

Conclusions: In this cohort of prehabilitation surgical oncology patients, frequencies of sarcopenia and SO were high, and baseline physical function was abnormal but improved significantly regardless of body composition. These findings suggest that patients have considerable prehabilitation needs and are capable of improving with comprehensive care.
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http://dx.doi.org/10.1177/15347354211000118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040607PMC
April 2021

Stable, precisely controlled, and switchable thulium-doped fiber laser based on cascaded mode interference filters.

Opt Express 2021 Mar;29(7):9786-9796

This research experimentally demonstrates a switchable, single-wavelength, thulium-doped fiber laser based on the cascading of a multimode-single-mode-multimode (MSM) fiber filter and a two-mode fiber (TMF) filter. When the MSM fiber filter suffers from bending, the blue-shift of the output spectrum can be obtained. A switchable lasing wavelength output is realized by bending the MSM fiber filter to cover different channels of the TMF filter. The output wavelength can be switched from 1982.54 to 1938.81 nm with an optical signal-to-noise ratio of higher than 40 dB. The wavelength interval of the switchable output is an integral multiple of the wavelength interval of the TMF filter. The stability of the output wavelength was tested within 60 min, and the wavelength shift and output power fluctuation were found to be less than 0.01 nm and 0.31 dB, respectively, which demonstrates a stable output performance.
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http://dx.doi.org/10.1364/OE.419283DOI Listing
March 2021

The Contributions of Language Skills and Comprehension Monitoring to Chinese Reading Comprehension: A Longitudinal Investigation.

Front Psychol 2021 19;12:625555. Epub 2021 Mar 19.

Department of Curriculum and Instruction, University of Huston, Houston, TX, United States.

This study examined how vocabulary, syntactic knowledge, and orthographic knowledge are related to comprehension monitoring and whether comprehension monitoring mediates the relations between these language skills and reading comprehension. Eighty-nine Chinese children were assessed on their vocabulary, syntactic knowledge, orthographic knowledge, and comprehension monitoring in Grade 1. Their reading comprehension skills were assessed in Grade 1 and Grade 3. Results showed that in Grade 1, comprehension monitoring mediated the relations between vocabulary and syntactic knowledge and reading comprehension. For Grade 3 reading comprehension, syntactic knowledge in Grade 1 was the only significant predictor. These findings indicate that multiple language skills make direct and indirect contributions comprehension monitoring to Chinese reading comprehension, and the relations would change as children's reading skills develop.
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http://dx.doi.org/10.3389/fpsyg.2021.625555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017195PMC
March 2021

Occurrence and abundance of poly- and perfluoroalkyl substances (PFASs) on microplastics (MPs) in Pearl River Estuary (PRE) region: Spatial and temporal variations.

Environ Pollut 2021 Mar 27;281:117025. Epub 2021 Mar 27.

School of Environment, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, 510632, China. Electronic address:

Although the occurrence and distribution of various chemicals on microplastics (MPs) has been widely studied, little was known about the concentrations of poly- and perfluoroalkyl substances (PFASs) on MPs. In this study, MPs from eight rivers draining into Pearl River Estuary (PRE) region were collected and analyzed. Higher concentrations of PFASs on MPs (105-9.07 × 10 ng g) were found in the drain outlets receiving wastewater from most urbanized cities with large population densities. On the other hand, lower concentrations of PFASs on MPs (10.3-227.8 ng g) were found in the drain outlets receiving wastewater mostly from agricultural and forested areas. Specially, 8:2 disubstituted polyfluoroalkyl phosphates (8:2 diPAP) was detected with the highest frequency, in 92.5% of the samples. Furthermore, a positive Spearman correlation was found between 6:2 disubstituted polyfluoroalkyl phosphates (6:2 diPAP) and perfluorotetradecanoic acid (PFTeDA) (r = 0.621, p = 0.012), indicating they might share similar sources. PFASs on MPs were found to vary significantly with different seasons. Higher concentrations of PFASs on MPs were found in dry seasons, while lower concentrations were observed in wet seasons. The results of this study should be important for the understanding of PFAS occurrence and distribution on MPs and the partitioning mechanism of PFASs on MPs in estuary systems.
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http://dx.doi.org/10.1016/j.envpol.2021.117025DOI Listing
March 2021

Metabolome and Transcriptome Analyses Reveal the Regulatory Mechanisms of Photosynthesis in Developing Leaves.

Int J Mol Sci 2021 Mar 5;22(5). Epub 2021 Mar 5.

Co-Innovation Centre for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing 210037, China.

Ginkgo ( L.) is a deciduous tree species with high timber, medicinal, ecological, ornamental, and scientific values, and is widely cultivated worldwide. However, for such an important tree species, the regulatory mechanisms involved in the photosynthesis of developing leaves remain largely unknown. Here, we observed variations in light response curves (LRCs) and photosynthetic parameters (photosynthetic capacity (P) and dark respiration rate (R)) of leaves across different developmental stages. We found the divergence in the abundance of compounds (such as 3-phospho-d-glyceroyl phosphate, sedoheptulose-1,7-bisphosphate, and malate) involved in photosynthetic carbon metabolism. Additionally, a co-expression network was constructed to reveal 242 correlations between transcription factors (TFs) and photosynthesis-related genes ( < 0.05, |r| > 0.8). We found that the genes involved in the photosynthetic light reaction pathway were regulated by multiple TFs, such as bHLH, WRKY, ARF, IDD, and TFIIIA. Our analysis allowed the identification of candidate genes that most likely regulate photosynthesis, primary carbon metabolism, and plant development and as such, provide a theoretical basis for improving the photosynthetic capacity and yield of ginkgo trees.
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http://dx.doi.org/10.3390/ijms22052601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961846PMC
March 2021

Manifestation of cardiac injury in hospitalised patients with COVID-19.

Int J Clin Pract 2021 Mar 31:e14197. Epub 2021 Mar 31.

Department of Cardiology, National Center of Gerontology, Institute of Geriatric Medicine, Beijing Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Background: COVID-19 has been sweeping the world since it emerged in late December 2019. However, little is known about cardiac injury in hospitalised COVID-19 patients. This study is to investigate the incidence and characteristics of myocardial injury in COVID-19 patients admitted in hospital.

Methods: Fifty-four COVID-19 patients were enrolled in one ward in Tongji Hospital, Wuhan, China, and 5 were excluded caused by missing cardiac troponin I levels. Forty-nine participants were included in the final analysis. The clinical manifestations of hospitalised patients were analysed. Patients were divided into two groups, cardiac injury group and non-cardiac injury group, based on whether cardiac troponin I was elevated. Epidemic characteristics and laboratory test results were analysed in these two group.

Results: The average age of patients in the cardiac injury group was older (68.0 years old) than that in the non-cardiac injury group (61.5 years old). The percentages of patients with diabetes and critically severe pneumonia in the cardiac injury group were 38.5% and 38.5% respectively. Lymphocytes were decreased in 53.1% of all enrolled patients, but this decrease was more prominent (76.9%) in the cardiac injury group than the non-cardiac injury group (44.4%). Patients in the cardiac injury group also had lower platelet counts.

Conclusions: COVID-19 can cause cardiac injury in many patients. It is more common in older patients and patients with diabetes and is associated with a significant decrease in lymphocytes.
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http://dx.doi.org/10.1111/ijcp.14197DOI Listing
March 2021

A Predictive Nomogram for Red Blood Cell Transfusion in Pheochromocytoma Surgery: A Study on Improving the Preoperative Management of Pheochromocytoma.

Front Endocrinol (Lausanne) 2021 11;12:647610. Epub 2021 Mar 11.

Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Purpose: Surgery is the major treatment option for pheochromocytoma but carries potential risks, including hemorrhage and hemodynamic instability. Even with laparoscopic adrenalectomy, intraoperative blood transfusion happens from time to time, but few studies have investigated risk factors. For the first time we develop and validate a nomogram for prediction of red blood cell transfusion in pheochromocytoma surgery.

Methods: There were 246 patients in our center and 56 patients in Peking Union Medical College Hospital, who underwent pheochromocytoma surgery, enrolled in the study. We incorporated clinical and radiological risk factors, and presented this with a nomogram. Lasso regression model was used for feature selection. Logistic regression analysis was performed to identify the odd ratios. The performance of the nomogram was assessed with respect to its discrimination, calibration and clinical usefulness.

Results: Thirty-two features were reduced to five, which were phenoxybenzamine use, phenoxybenzamine treatment duration, preinduction heart rate, tumor diameter and surgical procedure. The model showed good discrimination (C-index, 0.857; 95% CI, 0.781-0.836) and application in the validation sets also gave good discrimination (internal validation: C-index, 0.831; 95% CI, 0.750-0.822; external validation: C-index, 0.924; 95% CI, 0.766-1.000). Calibration tested with the Hosmer-Lemeshow test yielded a good agreement between prediction and observation (training P=0.358; internal validation P=0.205; external validation P=0.395). Odd ratios of phenoxybenzamine use, phenoxybenzamine treatment duration, preinduction HR, tumor diameter and open surgery were 13.32 (95% CI, 1.48-197.38; P = 0.034), 1.04 (95% CI, 0.99-1.08; P = 0.092), 1.04 (95% CI, 1.01-1.08; P=0.006), 1.03 (95% CI, 1.02-1.06; P<0.001), 17.13 (95% CI, 5.18-78.79; P<0.001), respectively. Decision curve analysis demonstrated the clinical usefulness of the nomogram.

Conclusions: This study presents a nomogram that may be used to facilitate the prediction of red blood cell transfusion in pheochromocytoma surgery and help to do the preoperative management more efficiently.
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http://dx.doi.org/10.3389/fendo.2021.647610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006300PMC
March 2021

HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia.

Nat Commun 2021 03 29;12(1):1956. Epub 2021 Mar 29.

Department of Molecular Medicine, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.

Nucleophosmin (NPM1) is the most commonly mutated gene in acute myeloid leukemia (AML) resulting in aberrant cytoplasmic translocation of the encoded nucleolar protein (NPM1c). NPM1c maintains a unique leukemic gene expression program, characterized by activation of HOXA/B clusters and MEIS1 oncogene to facilitate leukemogenesis. However, the mechanisms by which NPM1c controls such gene expression patterns to promote leukemogenesis remain largely unknown. Here, we show that the activation of HOXBLINC, a HOXB locus-associated long non-coding RNA (lncRNA), is a critical downstream mediator of NPM1c-associated leukemic transcription program and leukemogenesis. HOXBLINC loss attenuates NPM1c-driven leukemogenesis by rectifying the signature of NPM1c leukemic transcription programs. Furthermore, overexpression of HoxBlinc (HoxBlincTg) in mice enhances HSC self-renewal and expands myelopoiesis, leading to the development of AML-like disease, reminiscent of the phenotypes seen in the Npm1 mutant knock-in (Npm1) mice. HoxBlincTg and Npm1 HSPCs share significantly overlapped transcriptome and chromatin structure. Mechanistically, HoxBlinc binds to the promoter regions of NPM1c signature genes to control their activation in HoxBlincTg HSPCs, via MLL1 recruitment and promoter H3K4me3 modification. Our study reveals that HOXBLINC lncRNA activation plays an essential oncogenic role in NPM1c leukemia. HOXBLINC and its partner MLL1 are potential therapeutic targets for NPM1c AML.
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http://dx.doi.org/10.1038/s41467-021-22095-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007823PMC
March 2021

Correlation study of parabens in urine, serum, and seminal plasma of adult men in Beijing, China.

Environ Sci Pollut Res Int 2021 Mar 28. Epub 2021 Mar 28.

Department of Male Clinical Research, the Key Laboratory of Male Reproductive Health of National Health Commission of PRC, Human Sperm Bank, Research Institute of National Health Commission, Beijing, 100081, China.

The adverse effects of parabens raise concerns about their extensive use as preservatives in consumer products, especially in cosmetics. Until now, their distribution and excretion in humans have attracted little attention. Here, we quantified various agents including, for the first time, methyl-; ethyl-; n-propyl-; n-butyl-, and i-butylparaben (MeP, EtP, PrP, n-BuP, i-BuP); methyl- and ethyl-protocatechuate (OH-MeP and OH-EtP); hydroxybenzoic acid (4-HB); and 3,4-dihydroxybenzoic acid (3,4-DHB) in urine, serum, and seminal plasma samples from 50 healthy Chinese men in Beijing, China. Urine paraben concentrations were 1-2 orders of magnitudes higher than those in serum and seminal plasma. MeP and PrP were predominant and correlated with each other in the urine, serum, and seminal plasma. In urine, we observed a significant correlation between MeP and OH-MeP; EtP and OH-EtP; and 4-HB and 3,4-DHB concentrations. All these results provide new information on parabens as biomarkers for the assessment of exposure.
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http://dx.doi.org/10.1007/s11356-021-13625-yDOI Listing
March 2021

Simultaneous differential network analysis and classification for matrix-variate data with application to brain connectivity.

Biostatistics 2021 Mar 26. Epub 2021 Mar 26.

Department of Statistics, School of Management, Fudan University, Shanghai, 200433, China.

Growing evidence has shown that the brain connectivity network experiences alterations for complex diseases such as Alzheimer's disease (AD). Network comparison, also known as differential network analysis, is thus particularly powerful to reveal the disease pathologies and identify clinical biomarkers for medical diagnoses (classification). Data from neurophysiological measurements are multidimensional and in matrix-form. Naive vectorization method is not sufficient as it ignores the structural information within the matrix. In the article, we adopt the Kronecker product covariance matrices framework to capture both spatial and temporal correlations of the matrix-variate data while the temporal covariance matrix is treated as a nuisance parameter. By recognizing that the strengths of network connections may vary across subjects, we develop an ensemble-learning procedure, which identifies the differential interaction patterns of brain regions between the case group and the control group and conducts medical diagnosis (classification) of the disease simultaneously. Simulation studies are conducted to assess the performance of the proposed method. We apply the proposed procedure to the functional connectivity analysis of an functional magnetic resonance imaging study on AD. The hub nodes and differential interaction patterns identified are consistent with existing experimental studies, and satisfactory out-of-sample classification performance is achieved for medical diagnosis of AD.
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http://dx.doi.org/10.1093/biostatistics/kxab007DOI Listing
March 2021

Schottky barrier heights in two-dimensional field-effect transistors: from theory to experiment.

Rep Prog Phys 2021 Apr 27;84(5). Epub 2021 Apr 27.

State Key Laboratory for Mesoscopic Physics and Department of Physics, Peking University, Beijing 100871, People's Republic of China.

Over the past decade, two-dimensional semiconductors (2DSCs) have aroused wide interest due to their extraordinary electronic, magnetic, optical, mechanical, and thermal properties, which hold potential in electronic, optoelectronic, thermoelectric applications, and so forth. The field-effect transistor (FET), a semiconductor gated with at least three terminals, is pervasively exploited as the device geometry for these applications. For lack of effective and stable substitutional doping techniques, direct metal contact is often used in 2DSC FETs to inject carriers. A Schottky barrier (SB) generally exists in the metal-2DSC junction, which significantly affects and even dominates the performance of most 2DSC FETs. Therefore, low SB or Ohmic contact is highly preferred for approaching the intrinsic characteristics of the 2DSC channel. In this review, we systematically introduce the recent progress made in theoretical prediction of the SB height (SBH) in the 2DSC FETs and the efforts made both in theory and experiments to achieve low SB contacts. From the comparison between the theoretical and experimentally observed SBHs, the emerging first-principles quantum transport simulation turns out to be the most powerful theoretical tool to calculate the SBH of a 2DSC FET. Finally, we conclude this review from the viewpoints of state-of-the-art electrode designs for 2DSC FETs.
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http://dx.doi.org/10.1088/1361-6633/abf1d4DOI Listing
April 2021

Targeting P2 receptors in purinergic signaling: a new strategy of active ingredients in traditional Chinese herbals for diseases treatment.

Purinergic Signal 2021 Mar 22. Epub 2021 Mar 22.

Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Adenosine triphosphate (ATP) and its metabolites adenosine diphosphate, adenosine monophosphate, and adenosine in purinergic signaling pathway play important roles in many diseases. Activation of P2 receptors (P2R) channels and subsequent membrane depolarization can induce accumulation of extracellular ATP, and furtherly cause kinds of diseases, such as pain- and immune-related diseases, cardiac dysfunction, and tumorigenesis. Active ingredients of traditional Chinese herbals which exhibit superior pharmacological activities on diversified P2R channels have been considered as an alternative strategy of disease treatment. Experimental evidence of potential ingredients in Chinese herbs targeting P2R and their pharmacological activities were outlined in the study.
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http://dx.doi.org/10.1007/s11302-021-09774-xDOI Listing
March 2021