Publications by authors named "Yimo Wang"

5 Publications

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Metal ion implantation into transparent dielectric slab: an effective route to high-stability localized surface plasmon resonance sensors.

Nanotechnology 2021 Oct 12. Epub 2021 Oct 12.

College of Science, China University of Petroleum East China - Qingdao Campus, No. 66, West Changjiang Road, Huangdao District, Qingdao, Shandong, 266580, CHINA.

Ag/SiOand Au/SiOsamples were prepared by separately implanting 30 keV Ag and Au ions into 0.5-mm-thick SiOslabs at a fluence of 6 × 10ion/cm, and their optical and structural properties were studied in detail by using a fiber spectrometer and a transmission electron microscope, respectively. Our results showed that the two samples featured by their respective nanocomposite surface layers were asymmetrical in structure, and hence, their characteristic signals in the reflectance spectra excited by the lights incident from the rear surfaces were able to exhibit corresponding blueshifts when the overlays on the implanted surfaces were increased in refractive index with respect to air. Our results also showed that each of characteristic signals was strongly dependent on the localized surface plasmon resonance (LSPR) behavior of the involved Ag or Au nanoparticles (NPs), and it could not appear at a wavelength position smaller than or equal to that of the LSPR absorption peak since the involved Ag or Au NPs were quite small in size. These results meant that the two samples could be regarded as the LSPR sensors with a negative refractive index sensitivity (RIS), although their sensing abilities would lose when the overlays were very large in refractive index. Especially, the two samples were demonstrated to be relatively high in stability because the involved Ag and Au NPs were closely hugged and chemically protected by the matrices of SiO, and consequently, they could have a chance to become prospective sensing devices in some special fields as long as their RISs and linearities could be improved in the future. The above findings substantially confirmed that the metal ion implantation into transparent dielectric slab was an effective route to the high-stability LSPR sensors.
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http://dx.doi.org/10.1088/1361-6528/ac2f23DOI Listing
October 2021

A new sawfly of Megalodontesidae (Insecta, Hymenoptera, Pamphilioidea) with pectinate antennae from the Early Cretaceous of China.

Zookeys 2019 2;893:115-123. Epub 2019 Dec 2.

College of Life Sciences and Academy for Multidisciplinary Studies, Capital Normal University, 105 Xisanhuanbeilu, Haidian District, Beijing 100048, China Capital Normal University Beijing China.

A new sawfly of Megalodontesidae, , is described from the Lower Cretaceous Yixian Formation of Northeastern China. It is established mainly based on the pectinate antenna comprising 42 flagellomeres and the proximal 28 bearing apical rami, which gradually shorten in length toward the apex of the flagellum. The pterostigma of the forewing is infuscated apically and on the hind wing, vein 1-Rs is nearly equal to 1r-m and slightly shorter than 1-M. The first tergum is widely excised posteriorly and roundly protruding laterally alike in . This find supports that pectinate antennae in extant sawflies of Megalodontesidae originated at least during or before the Early Cretaceous.
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http://dx.doi.org/10.3897/zookeys.893.38512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901609PMC
December 2019

DNA methyltransferase activity detection based on fluorescent silver nanocluster hairpin-shaped DNA probe with 5'-C-rich/G-rich-3' tails.

Biosens Bioelectron 2015 Jun 7;68:736-740. Epub 2015 Feb 7.

College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan, Hubei 430072, PR China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, PR China. Electronic address:

DNA methylation has received a large amount of attention due to its close relationship to a wide range of biological phenomena, such as gene activation, gene imprinting, and chromatin stability. Herein, we have designed a hairpin-shaped DNA probe with 5'-C-rich/G-rich-3' tails and developed a simple and reliable fluorescence turn-off assay for DNA adenine methylation (Dam) methyltransferase (MTase) detection combining site recognition and the fluorescence enhancement of DNA-templated silver nanoclusters (DNA-AgNCs) by guanine-rich DNA sequences. A designed hairpin probe with 5' CCCTTACCCC and 3' GGGTGGGGTGGGGTGGGG displays a bright red emission after reacting with AgNO3 and NaBH4. In the presence of Dam MTase, the methylation-sensitive restriction endonuclease Dpn I which has the same recognition site with the Dam MTase can split the probe, freeing the G-rich sequence from the C-rich sequence, thus quenching the fluorescence of DNA-AgNCs. Compared to traditional fluorescent-based methods, this strategy is simple and inexpensive. A linear response to concentrations of Dam MTase which range from 1 U/mL to 100 U/mL and a detection limit of 1 U/mL are obtained without any amplification steps. In addition, we also demonstrate the method can be used for evaluation and screening of inhibitors for Dam MTase.
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http://dx.doi.org/10.1016/j.bios.2015.02.005DOI Listing
June 2015

The bed nucleus of the stria terminalis is critical for anxiety-related behavior evoked by CO2 and acidosis.

J Neurosci 2014 Jul;34(31):10247-55

Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, Iowa 52242, Department of Psychiatry, University of Iowa, Iowa City, Iowa 52242, Medical Scientist Training Program, University of Iowa, Iowa City, Iowa 52242, Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, Department of Neurosurgery, University of Iowa, Iowa City, Iowa 52242, and Department of Veterans Affairs Medical Center, Iowa City, Iowa 52246

Carbon dioxide (CO2) inhalation lowers brain pH and induces anxiety, fear, and panic responses in humans. In mice, CO2 produces freezing and avoidance behavior that has been suggested to depend on the amygdala. However, a recent study in humans with bilateral amygdala lesions revealed that CO2 can trigger fear and panic even in the absence of amygdalae, suggesting the importance of extra-amygdalar brain structures. Because the bed nucleus of the stria terminalis (BNST) contributes to fear- and anxiety-related behaviors and expresses acid-sensing ion channel-1A (ASIC1A), we hypothesized that the BNST plays an important role in CO2-evoked fear-related behaviors in mice. We found that BNST lesions decreased both CO2-evoked freezing and CO2-conditioned place avoidance. In addition, we found that CO2 inhalation caused BNST acidosis and that acidosis was sufficient to depolarize BNST neurons and induce freezing behavior; both responses depended on ASIC1A. Finally, disrupting Asic1a specifically in the BNST reduced CO2-evoked freezing, whereas virus-vector-mediated expression of ASIC1A in the BNST of Asic1a(-/-) and Asic1a(+/+) mice increased CO2-evoked freezing. Together, these findings identify the BNST as an extra-amygdalar fear circuit structure important in CO2-evoked fear-related behavior.
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http://dx.doi.org/10.1523/JNEUROSCI.1680-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115136PMC
July 2014

Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity.

Nat Neurosci 2014 Aug 22;17(8):1083-91. Epub 2014 Jun 22.

1] Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa, USA. [2] Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA. [3] Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, Iowa, USA. [4] Department of Neurosurgery, University of Iowa, Iowa City, Iowa, USA. [5] Department of Veterans Affairs Medical Center, Iowa City, Iowa, USA.

Acid-sensing ion channel 1A (ASIC1A) is abundant in the nucleus accumbens (NAc), a region known for its role in addiction. Because ASIC1A has been suggested to promote associative learning, we hypothesized that disrupting ASIC1A in the NAc would reduce drug-associated learning and memory. However, contrary to this hypothesis, we found that disrupting ASIC1A in the mouse NAc increased cocaine-conditioned place preference, suggesting an unexpected role for ASIC1A in addiction-related behavior. Moreover, overexpressing ASIC1A in rat NAc reduced cocaine self-administration. Investigating the underlying mechanisms, we identified a previously unknown postsynaptic current during neurotransmission that was mediated by ASIC1A and ASIC2 and thus well positioned to regulate synapse structure and function. Consistent with this possibility, disrupting ASIC1A altered dendritic spine density and glutamate receptor function, and increased cocaine-evoked plasticity, which resemble changes previously associated with cocaine-induced behavior. Together, these data suggest that ASIC1A inhibits the plasticity underlying addiction-related behavior and raise the possibility of developing therapies for drug addiction by targeting ASIC-dependent neurotransmission.
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http://dx.doi.org/10.1038/nn.3750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115047PMC
August 2014
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