Publications by authors named "Yimin Cheng"

32 Publications

Examining the Mechanisms of Huachansu injection on Liver Cancer through Integrated Bioinformatics Analysis.

Recent Pat Anticancer Drug Discov 2022 May 11. Epub 2022 May 11.

Department of gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Objective: To explore the potential anti-liver cancer mechanism of Huachansu injection through integrated bioinformatics analysis.

Methods: Active ingredients of Huachansu injection (extraction of toad skin) were obtained, and their potential drug targets were predicted via SwissTargetPrediction database. Liver cancer disease targets were identified from the GEO (Gene Expression Omnibus) dataset and four public databases. Then protein-protein interaction(PPI) network of toad skin was constructed. GO (Gene ontology) enrichment analysis and KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analysis were performed subsequently. Finally, molecular docking was performed using AutoDock Vina.

Results: In the search for therapeutic targets, twenty active components of toad skin were screened for further study, five hundred and sixty-eight targets of components were identified. In the search for disease targets, three thousand two hundred and twenty-seven genes were identified after removal of duplicated genes, one hundred and fifty-nine genes were up-regulated in liver cancer samples while two hundred and seventy-eight were down-regulated in liver cancer patients. After predicting the therapeutic targets of the components, the results were cross-checked with the disease targets, thirteen up-regulated targets and ten down-regulated targets were obtained. Finally, in the results of molecular docking, seven targets (CDK1, AKR1B1, MMP12, AURKB, CHEK1, AURKA, TTK) were potential up-regulated targets, three targets (SHBG, SRD5A2, NR1I2) were potential down-regulated targets, all of which have the best binding energy and molecular interactions.

Conclusion: CDK1, AKR1B1, MMP12, AURKB, CHEK1, AURKA, TTK could be potential up-regulated target proteins of Huachansu injection for treating liver cancer. The mechanism of Huachansu injection in the treatment of liver cancer through these up-regulated targets is related to cell cycle, cellular senescence cellular senescence, viral carcinogenesis, p53 signaling pathway. SHBG, SRD5A2, and NR1I2 could be potential down-regulated target proteins of Huachansu injection in treating liver cancer.
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http://dx.doi.org/10.2174/1574892817666220511162046DOI Listing
May 2022

Meta analysis for insomnia Guizhi Gancao Longgu Muli decoction for insomnia A meta-analysis.

Complement Ther Clin Pract 2022 May 23;47:101550. Epub 2022 Feb 23.

Ming'e Department, Shuangyashan, 155100, Heilongjiang Prov., China.

Background: Guizhi Gancao Longgu Muli Decoction can make a good effect on the insomnia under the catalogue of traditional Chinese medicine.

Method: To search the databases:Pubmed, Web of Science, EMBASE, the Cochrane Library, the China National Knowledge Infrastructure (CNKI), the China Biology Medicine disc (CBMdisc), the China Science and Technology Journal Database (VIP), the Wanfang.

Results: Fifteen randomized controlled trials were included, totally including 1164 participants. After summarizing the observational index revised according to the "Guiding Principles for Clinical Research of New Chinese Medicines", we found that the curative effect of the trial group is 2.29 times that of the control group in the fixed effect model which had a statistically significant difference [OR = 2.293681, 95%CI = 0.3266112-5.83]. And the Pittsburgh Sleep Quality Index (PSQI) which had 7 different dimensions, including subjective sleep quality[p = 0.001 < 0.05], sleep latency, sleep duration[p = 0.000 < 0.05], habitual SE[p = 0.000 < 0.05], sleep disorders[p = 0.002 < 0.05], use of sleep medications[p = 0.000 < 0.05], and daytime dysfunction[p = 0.000 < 0.05], showed a higher scores in the trial group than the one in the control group in every dimension. The final results of the total scores in PSQI also showed a higher scores in trial group with a p = 0.000 < 0.05 (Test of WMD), suggest a statistically significant difference. While the adverse effects showed a lower rate in the trial group than the one in the control group under a fixed-effect model, with a p = 0.000 < 0.05, indicate a statistically significant difference.

Conclusion: The efficacy and safety of GGLMD in the trial groups are better than the modern western medicine in the control groups.
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http://dx.doi.org/10.1016/j.ctcp.2022.101550DOI Listing
May 2022

Pregnancy-associated decrease of Siaα2-3Gal-linked glycans on salivary glycoproteins affects their binding ability to avian influenza virus.

Int J Biol Macromol 2021 Aug 17;184:339-348. Epub 2021 Jun 17.

Laboratory for Functional Glycomics, College of Life Sciences, Northwest University, Xi'an, China. Electronic address:

Salivary glycoproteins are known as an important barrier to inhibit influenza infection by presenting sialic acid (Sia) ligands that can bind with viral hemagglutination. Here, to further understand why pregnant women are more vulnerable to avian influenza virus (AIV), we investigated the alteration of protein sialylation in the saliva of women during pregnancy and postpartum, and its impact on the saliva binding affinity to AIV. Totally 1200 saliva samples were collected, the expression levels of terminal α2-3/6-linked Sia on salivary proteins were tested and validated, and the binding activities of salivary proteins were assessed against 3 strains of AIV and the H1N1 vaccine. Result showed that the expression of terminal α2-3-linked Sia in the saliva of women decreased dramatically during pregnancy compared to that of non-pregnancy control, especially for women in the second or third trimester (fold change = 0.53 and 0.37, p < 0.001). And their salivary protein binding ability to AIV declined accordingly. The variation of terminal α2-3-linked Sia on salivary MUC5B and IgA was consistent with the above results. This study indicates that the decrease of terminal α2-3-linked Sia on salivary glycoproteins of pregnant women affects their binding ability to AIV, which may provide new insights into AIV prevention and control.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.06.006DOI Listing
August 2021

The Influence of NDRG1 Single Nucleotide Polymorphisms on Glioma Risk and Prognosis in Chinese Han Population.

Cell Mol Neurobiol 2022 Aug 12;42(6):1949-1964. Epub 2021 Mar 12.

Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, 712082, Shaanxi, China.

Glioma is a highly fatal malignant tumor with a high recurrence rate, poor clinical treatment effect, and prognosis. We aimed to determine the association between single nucleotide polymorphisms (SNPs) of NDRG1 and glioma risk and prognosis in the Chinese Han population. 5 candidate SNPs were genotyped by Agena MassARRAY in 558 cases and 503 controls; logistic regression was used to analyze the relationship between SNPs and glioma risk. We used multi-factor dimensionality reduction to analyze the interaction of 'SNP-SNP'; the prognosis analysis was performed by log-rank test, Kaplan-Meier analysis, and Cox regression model. Our results showed that the polymorphisms of rs3808599 was associated with the reduction of glioma risk in all participants (OR 0.41, p = 0.024) and the participants ≤ 40 years old (OR 0.30, p = 0.020). rs3802251 may reduce glioma risk in all participants (OR 0.79, p = 0.008), the male participants (OR 0.68, p = 0.033), and astrocytoma patients (OR 0.81, p = 0.023). rs3779941 was associated with poor glioma prognosis in all participants (HR = 2.59, p = 0.039) or astrocytoma patients (HR = 2.63, p = 0.038). We also found that the key factors for glioma prognosis may include surgical operation, radiotherapy, and chemotherapy. This study is the first to find that NDRG1 gene polymorphisms may have a certain association with glioma risk or prognosis in the Chinese Han population.
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http://dx.doi.org/10.1007/s10571-021-01075-6DOI Listing
August 2022

Ninjurin 2 rs118050317 gene polymorphism and endometrial cancer risk.

Cancer Cell Int 2021 Jan 4;21(1). Epub 2021 Jan 4.

The National Engineering Research Centre for Miniaturized Detection Systems, College of Life Science, Northwest University, #229 North TaiBai Road, Xi'an, 710069, Shaanxi, China.

Background: Endometrial cancer is one of the most common female reproductive system tumors. Ninjurin2 (NINJ2) is a new adhesion factor. As a vascular susceptibility gene, it is highly expressed in other cancers and promotes the growth of cancer cells. We conducted an association analysis between NINJ2 gene polymorphism and endometrial cancer risk.

Methods: Five SNPs rs118050317, rs75750647, rs7307242, rs10849390 and rs11610368 of NINJ2 gene were genotyped in 351 endometrial cancer patients and 344 healthy controls. The clinical index difference between cases and controls were tested by one-way analysis of variance. The allele and genotype frequency of cases and controls were been compared by Chi square test. The odds ratios (OR) with 95% confidence interval (95% CI) were examined by logistic regression analysis.

Results: The SNP rs118050317 mutant allele C and homozygote CC genotype were significant increased the endometrial cancer risk (OR 1.46, 95% CI 1.04-2.06, p = 0.028; OR 8.43, 95% CI 1.05-67.89, p = 0.045). In the clinical index analysis, there were significant higher quantities of CEA, CA125 and AFP in cases serum than controls.

Conclusion: The NINJ2 gene polymorphism loci rs118050317 mutant allele C was associated with an increased risk of endometrial cancer. CEA, CA125 and AFP quantities were significant higher in endometrial cancer patients.
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http://dx.doi.org/10.1186/s12935-020-01646-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784262PMC
January 2021

Suppression of bromodomain-containing protein 4 protects trophoblast cells from oxidative stress injury by enhancing Nrf2 activation.

Hum Exp Toxicol 2021 May 23;40(5):742-753. Epub 2020 Oct 23.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of 117799Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Oxidative stress is considered a key hallmark of preeclampsia, which causes the dysregulation of trophoblast cells, and it contributes to the pathogenesis of preeclampsia. Emerging evidence has suggested bromodomain-containing protein 4 (BRD4) as a key regulator of oxidative stress in multiple cell types. However, whether BRD4 participates in regulating oxidative stress in trophoblast cells remains undetermined. The current study was designed to explore the potential function of BRD4 in the regulation of oxidative stress in trophoblast cells. Our data revealed that BRD4 expression was elevated in trophoblast cells stimulated with hydrogen peroxide. Exposure to hydrogen peroxide caused marked decreases in the levels of proliferation and invasion but promoted apoptosis and the production of ROS in trophoblast cells. Knockdown of BRD4, or treatment with a BRD4 inhibitor, markedly increased the levels of cell proliferation and invasion and decreased apoptosis and ROS production following the hydrogen peroxide challenge. Further data indicated that suppression of BRD4 markedly decreased the expression levels of Keap1, but increased the nuclear expression of Nrf2 and enhanced Nrf2-mediated transcriptional activity. BRD4 inhibition-mediated protective effects were markedly reversed by Keap1 overexpression or Nrf2 inhibition. Overall, these results demonstrated that BRD4 inhibition attenuated hydrogen peroxide-induced oxidative stress injury in trophoblast cells by enhancing Nrf2 activation via the downregulation of Keap1. Our study highlights the potential importance of the BRD4/Keap1/Nrf2 axis in the modulation of the oxidative stress response in trophoblast cells. Targeted inhibition of BRD4 may offer new opportunities for the development of innovative therapeutic approaches to treat preeclampsia.
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http://dx.doi.org/10.1177/0960327120968857DOI Listing
May 2021

Diet-induced obesity is associated with altered expression of sperm motility-related genes and testicular post-translational modifications in a mouse model.

Theriogenology 2020 Dec 17;158:233-238. Epub 2020 Sep 17.

Institute of Life Science and School of Life Science, Nanchang University, Nanchang, Jiangxi, 330031, China; Key Laboratory of Reproductive Physiology and Pathology in Jiangxi Province, Jiangxi Medical College of Nanchang University, Nanchang University, Nanchang, Jiangxi, 330031, China. Electronic address:

Obesity is a metabolic disease and its relation with male subfertility has aroused a growing concern. However, it is unclear whether gene expression and post-translational modifications (PTMs), two vital molecular mechanisms regulating cellular functions, are associated with obesity-induced male reproductive dysfunction. In this study, male obesity with compromised sperm motility was induced by a high-fat diet (HFD) using a mouse model. The expression of motility related-genes, the level of histone modifications, and the global profiles of post-translational modifications (PTMs), were examined in testes of HFD and control mice by quantitative real-time PCR and western blot, respectively. Outer dense fiber protein 2, a major component of outer dense fibers in the sperm tail, is the most obviously down-regulated gene out of 11 evaluated genes, showing a reduction of about 50% RNA level in testes of obese male mice compared with that in control mice. Semi-quantitative analysis of the western blot demonstrated that ∼56% enrichment of di-methylated histone (H)3 lysine (K)36, ∼59% enrichment of 2-hydroxyisobutyrylated H4K8, ∼32% decrease of propionylated H3K23, ∼33% decrease of crotonylated H4K8, and ∼45% decrease of acetylated H3K122 and H4K8 were detected in testes of male HFD mice compared with that in control mice. In addition, male obesity up-regulated the testicular levels of ubiquitination by ∼18%, tyrosine nitration by ∼20%, lysine succinylation by ∼25%, lysine benzoylation by ∼28%, lysine malonylation by ∼32%, lysine glutarylation by ∼36%, lysine propionylation by ∼42%, lysine 2-hydroxyisobutyrylation by ∼45%, and SUMO1 modification by ∼59%, and down-regulated the testicular levels of O-GlcNAcylation by ∼12%, lysine crotonylation by ∼22%, and lysine acetylation by 35%. These findings indicate that altered gene expression and PTMs are associated with the obesity-induced male reproductive dysfunction.
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http://dx.doi.org/10.1016/j.theriogenology.2020.09.023DOI Listing
December 2020

PFOA evokes extracellular Ca influx and compromises progesterone-induced response in human sperm.

Chemosphere 2020 Feb 8;241:125074. Epub 2019 Oct 8.

Department of Physiology, School of Basic Medical Sciences, Jiangxi Provincial Key Laboratory of Reproductive Physiology and Pathology, Nanchang University, Nanchang, 330006, PR China. Electronic address:

Perfluorooctane acid (PFOA), a persistent organic pollutant, is ubiquitously present in the environment and may detrimentally affect male reproductive health. In this study, mature human sperm were in vitro exposed to different concentrations of PFOA (0.25, 2.5 or 25 μg/ml) alone or in combination with progesterone (P4) to evaluate the toxicity and the potential mechanism of action. Exposure to high-dose PFOA (25 μg/ml) alone for 4 h caused a decline in capacity of human spermatozoa to penetrate synthetic mucus, with an increased production of reactive oxygen species (ROS). Furthermore, PFOA treatment (2.5 and 25 μg/ml) evoked a transient rise in intracellular calcium concentration [Ca] by activating the sperm-specific CatSper channel. However, preincubation with PFOA (2.5-25 μg/ml) for 4 h significantly suppressed P4-stimulated extracellular Ca influx in human spermatozoa. Moreover, PFOA pretreatment at all concentrations evaluated markedly compromised P4-induced acrosome reaction and sperm penetration into viscous medium. Taken together, these results suggest that PFOA exposure may impair human sperm function through inducing oxidative stress and disturbing P4-induced Ca signaling.
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http://dx.doi.org/10.1016/j.chemosphere.2019.125074DOI Listing
February 2020

Association between polymorphisms of MIR17HG and risk of colorectal cancer in the Chinese Han population.

Mol Genet Genomic Med 2019 06 3;7(6):e667. Epub 2019 Apr 3.

The National Engineering Research Centre for Miniaturized Detection Systems, College of Life Science, Northwest University, Xi'an, P.R. China.

Background: Colorectal cancer is the third most common cancer worldwide. Recently, an increasing number of evidences suggest that genetic susceptibility plays an important role in the occurrence of colorectal cancer. This study aimed to better understand the influence of MIR17HG polymorphisms on colorectal cancer susceptibility in the Chinese Han population.

Methods: We recruited 514 patients with colorectal cancer and 510 healthy controls to investigate the association between polymorphisms of MIR17HG and risk of colorectal cancer in the Chinese Han population. Genotyping was performed with the Agena MassARRAY platform. We used the χ test to compare the distributions of single nucleotide polymorphisms (SNPs) allele and genotypes frequencies between cases and controls. Odds ratios and 95% confidence intervals were calculated by logistic regression analysis to evaluate the association under genetic models. Linkage disequilibrium between the five SNPs was assessed using the Haploview software.

Results: Overall analysis found that rs7336610 and rs1428 and haplotype CTAGA were significantly associated with increased risk of colorectal cancer. However, we found rs7318578 was associated with a decreased risk of colorectal cancer in the dominant model. Stratification analysis showed that rs7336610, rs7318578, and rs1428 were also associated with rectal cancer risk. Gender stratification analysis found that rs7336610, rs7318578, rs17735387, and rs1428 were significantly associated with colorectal cancer risk in males.

Conclusion: In conclusion, this study indicated that the polymorphisms of MIR17HG were associated with colorectal cancer risk. Therefore, our findings may provide new insights into the development of colorectal cancer. Further association and functional studies are of great importance to confirm these results and to define the potential biological mechanism of colorectal cancer.
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http://dx.doi.org/10.1002/mgg3.667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565593PMC
June 2019

CCR6 is required for ligand-induced CatSper activation in human sperm.

Oncotarget 2017 Oct 5;8(53):91445-91458. Epub 2017 Sep 5.

Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.

CatSper channel has been considered the principal sperm Ca channel responsible for the cytosolic Ca elevation required for various sperm functions necessary for fertilization [1-4]. However, the mechanism underlying the activation of CatSper channel by various physiological ligands remain incompletely understood. We have recently demonstrated the expression of C-C chemokine receptor 6 (CCR6) in sperm and Ca influx upon binding of human β-defensin 1 (DEFB1) to CCR6, which is important for sperm motility [5]. In the present study, we have demonstrated that CCR6 receptor and CatSper channel are both required for the Ca entry/current induced by physiological ligands DEFB1, chemokine (C-C motif) ligand 20 (CCL20) and progesterone in human sperm. CCR6 is co-localized and interacts with CatSper in human sperm. Ca influx mediated by CCR6 and CatSper is required for essential sperm functions, including motility, hyperactivation and acrosome reaction, which are impaired in infertile sperm showing reduced levels of CCR6 and CatSper. The present finding suggests a critical role of CCR6 receptor in mediating ligand-induced, CatSper-dependent Ca influx required for various sperm functions and thus male fertility.
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http://dx.doi.org/10.18632/oncotarget.20651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710936PMC
October 2017

Acceptability of Phoenurse female condom and second-generation Femidom female condom in Chinese women.

J Obstet Gynaecol Res 2016 Nov 22;42(11):1567-1574. Epub 2016 Jul 22.

Social Medicine Center, National Research Institute for Family Planning, Beijing, China.

Aim: To compare the acceptability of Phoenurse female condom (PFC) and second-generation Femidom female condom (FC2) among Chinese women.

Methods: A randomized, cross-over clinical trial was carried out in women aged 20-49 years seeking family service in Qingdao, China, between April and October 2013. Women were classified into two groups using a computer-generated randomized sequence. Participants completed questionnaires at baseline and after using 10 of each type of female condom (FC).

Results: Of 290 women, 247 (85.2%) believed that FC could protect against sexually transmitted diseases and HIV. A total of 152 (52.5%) thought that the female condom (FC) contraceptive failure rate was higher, and 107 (36.9%) thought that FC could be reused before they participated in this study. After the study, 135 (46.6%) and 39 women (13.4%) would have been happy to use FC2 and PFC, respectively. Significant difference was noted between PFC and FC2 for the features color, lubrication and overall fit, rather than length, appearance, smell and application method. A total of 68 (23.5%) and 140 women (49.5%) liked FC2's color and lubrication better than PFC (44, 15.2%; 99, 34.6%). Also, 158 women (54.5%) preferred the overall fit of FC2 compared with PFC (143, 49.5%; P < 0.05).

Conclusion: Participants did not have sufficient knowledge about the contraceptive effect and use of FC. Lubrication means the smooth degree of using FC. Length means the size of FC. Appearance means the users' overall impression of the FC.
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http://dx.doi.org/10.1111/jog.13080DOI Listing
November 2016

Awareness of female condoms and failures reported with two different types in China.

Int J Gynaecol Obstet 2015 Feb 13;128(2):152-6. Epub 2014 Oct 13.

Social Medicine Center, National Research Institute for Family Planning, Beijing, China. Electronic address:

Objective: To explore knowledge and use of female condoms in China, and to compare four modes of failure between the Phoenurse female condom (PFC) and the second-generation Femidom female condom (FC2).

Methods: In a randomized, crossover trial, sexually active women aged 20-49years who attended a family planning service in Qingdao, China, were recruited between April and October, 2013. A computer-generated randomized sequence was used to assign participants (1:1) to group A (used 10 PFCs followed by 10 FC2s) or group B (used 10 FC2s followed by 10 PFCs). Study investigators and participants were masked to allocation. Participants completed questionnaires at baseline and after using the two types of FCs. They also kept coital logs.

Results: At baseline, 30 (10.3%) of 290 participants understood female condoms, but only 1 (0.3%) had ever used one. Total failure rates were 3.6% (420/11 578) and 2.3% (265/11 594) for PFC and FC2, respectively (P<0.001). Slippage was the most common form of failure, affecting 6.9% of PFC uses and 5.0% of FC2 uses. Breakage, misdirection, and slippage were significantly more common with the PFC than with the FC2 (P≤0.002).

Conclusion: Understanding of female condoms is poor in China. Failure is more common with the PFC than with the FC2.
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http://dx.doi.org/10.1016/j.ijgo.2014.08.017DOI Listing
February 2015

Risk factors associated with cesarean section in a Chinese rural population: a cross sectional study.

J Reprod Med 2012 Sep-Oct;57(9-10):441-5

Graduate School of Peking Union Medical College, and National Research Institute for Family Planning, Beijing, China.

Objective: To identify individual and clinical risk factors associated with cesarean section (CS) delivery in a Chinese rural population.

Study Design: A cross-sectional study was conducted with data from hospital medical records in Henan Province and Anhui Province, China, using univariate and multiple logistic regression analyses.

Results: Between January 1 and December 31, 2008, 46.3% (4,823/10,425) of deliveries were via CS in the study population. After adjustment for other variables, pregnant women in the 25-29-year-old (odds ratio [OR] 1.41, 95% confidence interval [CI] 1.24-1.61) and > or = 30-year-old (OR 1.73, 95% CI 1.46-2.04) age groups were more likely to give birth by CS as compared to the 20-24-year-old age group. Other independent factors related to a higher risk of CS included nonagricultural occupation (OR 1.44, 95% CI 1.27-1.62), gestational hypertension (OR 5.22, 95% CI 3.93-6.93), breech presentation (OR 10.47, 95% CI 6.37-17.20), dystocia (OR 28.62, 95% CI 24.62-33.28), and preterm delivery (OR 1.28, 95% CI 1.06-1.54).

Conclusion: Age, occupation, gestational hypertension, breech presentation, and dystocia may play an important role in the high level of CS among women in a Chinese rural population. Further comprehensive studies on both medical and nonmedical reasons for CS delivery are needed.
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December 2012

Medical abortion service in rural areas of Henan Province, China: a provider survey.

J Obstet Gynaecol Res 2013 Mar 25;39(3):672-9. Epub 2012 Sep 25.

Graduate School of Peking Union Medical College, Beijing, China.

Aim: The aim of this study was to explore the knowledge, attitudes and practices on medical abortion of abortion service providers in rural areas of China.

Material And Methods: A cross-sectional study via self-administered questionnaire was conducted among 362 abortion service providers from family planning service centers (FPSC) and hospitals in rural areas of Henan Province, China, between November 2009 and May 2010.

Results: Most of the providers were female (99.4%) and obstetricians/gynecologists (63.3%). The knowledge score achieved ranged from 9.4 to 78.1 points, with both the median and the mode of 56.3 points. Of the 52.2% (189/362) of providers having a preference on abortion method, 30.2% (57/189) preferred medical abortion, while 69.8% (132/189) preferred surgical abortion. In total, 50.7% (174/343) of the providers indicated the provision of medical abortion should be expanded, with the three biggest challenges in its further expansion being increased complications/failures, poor client knowledge/awareness, and problems with drug/equipment supplies. Of all the providers, 81.7% and 92.2% reported they had experience in providing medical abortion and surgical abortion, respectively. Medical abortion providers were mainly experienced in misoprostol with oral (81.8%)/vaginal (79.6%) prostaglandin (misoprostol/gemeprost).

Conclusion: Knowledge on medical abortion of providers working in rural China was at a moderate level. Providers preferred surgical abortion to medical abortion. Providers have more experience in providing surgical abortion than medical abortion. Efforts should be made to overcome the perceived challenges in future expansion of medical abortion.
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http://dx.doi.org/10.1111/j.1447-0756.2012.02004.xDOI Listing
March 2013

Study of knowledge and attitudes on medical abortion among Chinese health providers.

Int J Gynaecol Obstet 2012 Sep;118 Suppl 1:S28-32

Center for Social Medicine Research, National Research Institute for Family Planning (NRIFP), Beijing, China.

Objective: To investigate providers' knowledge and attitudes about medical abortion (MA) and their views regarding the main challenges to expanding the use of MA in urban and rural areas in China.

Methods: A total of 658 abortion providers were surveyed from November 7, 2009, to May 29, 2010.

Results: The providers' knowledge about MA was relatively poor, and most thought the risks of severe complications of MA were much higher than they are. Urban nonphysician providers were the least informed about MA. Most providers thought that the main challenges to an expanded use of MA were its lesser effectiveness in comparison to surgical abortion and women's lack of knowledge about it. In rural areas many providers thought that deficiencies of clinics, such as limited bed space and inadequate toilets and washing facilities, also posed serious obstacles to expanding MA use.

Conclusion: Abortion providers, especially urban nonphysician providers, need refresher training to strengthen their knowledge of the approved protocol for providing MA in China, and also of the indications, contraindications, and safety and efficacy of the method. Deficiencies at abortion facilities should be addressed as well, and they are more numerous in rural areas.
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http://dx.doi.org/10.1016/j.ijgo.2012.05.007DOI Listing
September 2012

Promoting contraceptive use among female rural-to-urban migrants in Qingdao, China: a comparative impact study of worksite-based interventions.

Eur J Contracept Reprod Health Care 2012 Oct 30;17(5):363-72. Epub 2012 Jul 30.

International Centre for Reproductive Health (ICRH), Ghent University, Belgium.

Background: We conducted a comparative study in worksites to assess the impact of sexual health promoting interventions on contraceptive use among female rural-to-urban migrants.

Study Design: In Qingdao ten manufacturing worksites were randomly allocated to a standard package of interventions (SPI) and an intensive package of interventions (IPI). The interventions ran from July 2008 to January 2009. Cross-sectional surveys at baseline and end line assessed the sexual behaviour of young female migrants. To evaluate the impact of the interventions we assessed pre- and post-time trends.

Results: From the SPI group 721 (baseline) and 615 (end line) respondents were considered. Out of the IPI group we included 684 and 603 migrants. Among childless migrants, self-reported contraceptive use increased significantly after SPI and IPI (adjusted odds ratio [aOR] = 3.23; 95% confidence interval [CI] = 1.52-6.84; p < 0.01 and aOR = 5.81; 95% CI = 2.63-12.80; p < 0.001, respectively). Childless migrants older than 22 years reported a greater use after IPI than after SPI.

Conclusion: Implementing current Chinese sexual health promotion programmes at worksites is likely to have a positive impact on migrant women working in the manufacturing industry of Qingdao. More comprehensive interventions seem to have an added value if they are well targeted to specific groups.
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http://dx.doi.org/10.3109/13625187.2012.696752DOI Listing
October 2012

Prevalence of inconsistent condom use and associated factors among HIV discordant couples in a rural county in China.

AIDS Behav 2013 Jun;17(5):1888-94

Center for Health Behaviours Research, School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, 5/F, School of Public Health and Primary Care, Prince of Wales Hospital, Shatin, N.T., Hong Kong, People's Republic of China.

A random sample consisting of 88 sexually active people living with HIV (PLWH) and their HIV negative spouses in rural China were interviewed. Data of 68 couples (77.2 %) who gave identical responses to whether they had been using condoms consistently in the last 12 months (n = 136) were analyzed. The results showed that 27.9 % of the discordant couples used condom inconsistently in the last year. Condom non-availability was the most commonly given main reason for not using condoms. Free condoms should be made available to these low-income couples. Suicidal ideation of the PLWH and the spouse's perception on 'whether someone could contract HIV via unprotected sexual intercourse with a HIV positive person' were significantly associated with inconsistent condom use in the last year. Education program should change the cognition about the risk for HIV transmission via unprotected sex. Integrated psychological services to reduce suicidal ideation are greatly warranted.
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http://dx.doi.org/10.1007/s10461-012-0269-zDOI Listing
June 2013

A cross-sectional study of contraceptive use among married women living in rural China.

Int J Gynaecol Obstet 2012 Aug 12;118(2):129-32. Epub 2012 Jun 12.

Graduate School of Peking Union Medical College, Beijing, China.

Objective: To examine the prevalence of contraceptive use in rural China and to determine factors that influence choice of contraceptive method.

Methods: A cross-sectional study was conducted using multistage cluster sampling to identify married women aged 20-49 years residing in Shaanxi Province, China. Data on demographics and contraceptive use were collected via detailed questionnaire.

Results: The prevalence of contraceptive use in the study population was 93.9% (19 599/20 878 eligible women). Among the women using contraceptives, 10 408 (53.1%) used sterilization (female and male) and 6947 (35.4%) chose an intrauterine device. In total, 2244 (11.4%) women used short-acting contraceptive (SAC) methods: condoms and pills accounted for 8.7% (n=1712) and 1.0% (n=216), respectively. Young age; high level of education; low parity; increased number of abortions; low frequency of sexual intercourse; long duration between marriage and delivery; and marriage after 1994 were all associated with SAC usage.

Conclusion: Although contraceptive use was high in rural China, the participants' awareness of free selection of contraceptive method and the rate of SAC use were both low. Appropriate and diverse family-planning services should be provided to meet the needs of women living in rural areas.
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http://dx.doi.org/10.1016/j.ijgo.2012.03.037DOI Listing
August 2012

A pilot theory-based intervention to improve resilience, psychosocial well-being, and quality of life among people living with HIV in rural China.

J Sex Marital Ther 2014 8;40(1):1-16. Epub 2013 May 8.

a Center for Health Behaviours Research, School of Public Health and Primary Care, Faculty of Medicine , The Chinese University of Hong Kong , Hong Kong , People's Republic of China.

This pilot study aimed at fostering resilience among people living with HIV and improving the HIV-negative participants' acceptance of people living with HIV. A group of 75 people living with HIV who were former blood/plasma donors and 36 HIV-negative fellow villagers in rural China participated in the intervention. The 8 sessions lasted for 4 months and were facilitated by trained local family-planning officers. Efficacy of the intervention was assessed using a pre- and postprogram study design; measurements were made at baseline, at completion, and 3 months afterward completion. The authors found that the HIV-positive participants increased their levels of resilience, social support, and quality of life and that they reported fewer symptoms of depression, anxiety, and stress at the completion of the intervention; most of these changes were sustained at the 3-month follow-up. Such participants also reported subjective improvements on problem-solving skills, self-confidence, and a feeling of being cared for by others. In addition, the HIV-negative participants' discriminatory attitudes toward people living with HIV were reduced after completing the intervention. The majority of the participants was satisfied with the intervention and would recommend it to others. The train-the-trainer approach was used effectively. Positive effects of the intervention have been revealed and future randomized controlled studies are warranted.
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http://dx.doi.org/10.1080/0092623X.2012.668512DOI Listing
August 2014

Study on sexual and reproductive health behaviors of unmarried female migrants in China.

J Obstet Gynaecol Res 2012 Apr 13;38(4):632-8. Epub 2012 Mar 13.

Graduate School of Peking Union Medical College, Beijing, China.

Aim: The purpose of this study was to broadly assess the level of knowledge, attitude and behaviors related to sexual and reproductive health (SRH) among unmarried female migrants in China.

Material And Methods: This cross-sectional study was conducted and a self-administered questionnaire was designed for collecting information on SRH including 15 items for knowledge, 8 items for attitude and some items for contraception and abortion related behaviors.

Results: A total of 1690 unmarried female migrants were interviewed. Most of the respondents had less knowledge of SRH. Only one-third of respondents was aware of emergency contraceptives and could freely talk about SRH with their friends. Over one-third of respondents were not willing to come into contact with someone with AIDS or STDs. In this study, 10.4% participants had an unwanted pregnancy and 95% of them had an abortion. Multivariate analysis showed that having a boyfriend, duration of employment in city, knowledge on SRH and freely discussing SRH with peer were associated with having premarital sex among these unmarried female migrants.

Conclusion: This study revealed that the unmarried female migrant was one of the most vulnerable groups concerning SRH. In some policy reforms, appropriate and cost-effective SRH services should be provided for these migrants.
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http://dx.doi.org/10.1111/j.1447-0756.2011.01753.xDOI Listing
April 2012

Perspectives of Chinese healthcare providers on medical abortion.

Int J Gynaecol Obstet 2011 Jul 14;114(1):15-7. Epub 2011 May 14.

Graduate School of Peking Union Medical College, Beijing, China.

Objective: To evaluate Chinese healthcare providers' knowledge regarding medical abortion, to understand provider preferences for abortion methods, and to investigate the role of remuneration on providers' decision making.

Methods: Between November 2009 and May 2010, 658 abortion service providers from family-planning service centers and hospitals in Shenzhen and Henan, China, were surveyed via self-administered questionnaires.

Results: The knowledge score (out of a maximum of 32) regarding medical abortion was 16-20 for 60.9% of the providers; 20.4% of the providers preferred medical abortion to surgical abortion, whereas 35.0% preferred surgical abortion. Overall, 72.2% of providers stated that they did not receive any commission for providing medical abortion or surgical abortion.

Conclusion: Most healthcare providers believed that surgical abortion was preferable to medical abortion. Efforts should be made to overcome the perceived disadvantages of medical abortion.
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http://dx.doi.org/10.1016/j.ijgo.2011.01.027DOI Listing
July 2011

[Intervention effects of promoting the use of contraceptives in migrant population working in factory].

Wei Sheng Yan Jiu 2011 Jan;40(1):82-5

Center for Social Medicine Research, National Research Institute for Family Planning, Beijing 100081, China.

Objective: To evaluate the effectiveness of an intervention program on promoting the use of contraceptives in migrant population working in factories, and to compare the difference of results between the basic intervention mode and the comprehensive intervention mode.

Methods: This was an epidemiologic intervention study carried out in each 2 factories in Shenzhen and Dongguan among migrant workers by comparing the effectiveness of a baseline survey and a end-line survey. The basic intervention mode was composed of spreading contraceptives and reproductive health information, conducting education and communication and providing references to access free services from family planning clinics (IEC). The comprehensive intervention mode provided more services on face to face counseling and distributing free contraceptives.

Results: The demographic characteristics of subjects before and after surveys were comparable. Whether in the basic group or comprehensive mode group, the awareness of contraceptive/reproductive health knowledge was increased significantly after intervention (P = 0.000), and the pass rate was higher in the comprehensive intervention group (P = 0.000). The self-reported most frequently used contraceptives was condoms. The proportion of using condoms and purchasing condoms was increased after intervention (P = 0.000) from 69.7% and 67.7% before intervention to 84.9% and 90.2% after basic intervention and 87.1% and 95.1% after comprehensive intervention. The proportion of using contraceptives every time was increased from 35.7% before intervention to 38.1% after basic intervention (P = 0.018) and to 42.9% after comprehensive intervention (P = 0.000).

Conclusion: Intervention measures based on implementing in factories were effective in promoting contraception among migrant workers, and the integration of counseling and free contraceptive services with IEC was better. Carrying on and extending this kind of intervention measures to other migrant population in similar conditions is suggested.
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January 2011

Determinants of unmet need for contraception among Chinese migrants: a worksite-based survey.

Eur J Contracept Reprod Health Care 2011 Feb 15;16(1):26-35. Epub 2010 Dec 15.

International Centre for Reproductive Health, Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Ghent University, Belgium.

Background: Considerable sexual and reproductive health (SRH) challenges have been reported among rural-to-urban migrants in China. Predictors thereof are urgently needed to develop targeted interventions.

Study Design: A cross-sectional study assessed determinants of unmet need for contraception using semi-structured interviews in two cities in China: Guangzhou and Qingdao.

Results: Between July and September 2008, 4867 female rural-to-urban migrants aged 18-29 years participated in the study. Of these, 2264 were married or cohabiting. Among sexually-active women (n = 2513), unmet need for contraception was reported by 36.8% and 51.2% of respondents in Qingdao and Guangzhou, respectively; it was associated with being unmarried, having no children, less schooling, poor SRH knowledge, working in non-food industry, and not being covered by health insurance. A substantial proportion of unmarried migrants reported they had sexual intercourse (16.6 % in Qingdao and 21.4% in Guangzhou) contrary to current sexual standards in China.

Conclusion: The study emphasises the importance of improving the response to the needs of rural-to-urban migrants and recommends strategies to address the unmet need for contraception. These should enhance open communication on sexuality, increase the availability of condoms, and improve health insurance coverage.
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http://dx.doi.org/10.3109/13625187.2010.536920DOI Listing
February 2011

Impact of post-abortion family planning services on contraceptive use and abortion rate among young women in China: a cluster randomised trial.

Eur J Contracept Reprod Health Care 2009 Feb;14(1):46-54

The Danish Epidemiology Science Centre, University of Aarhus, Aarhus, Denmark.

Objectives: To compare two post-abortion family planning (FP) service packages on contraceptive use and repeat abortion rate among young women in three cities in China.

Methods: In this cluster-randomized trial, one FP service package included provision of limited information and referral to existing FP services, and the other, more comprehensive, package consisted--in addition to the above simple package--of individual counselling, free provision of contraceptive materials, and involvement of the male partner. Eight matched pairs of hospitals were certified by centralized randomization. Women undergoing abortion were followed up for six months, and data were collected in two rounds, before and after the intervention.

Results: We followed a total of 2336 women younger than 25 years (555 before and 555 after the simple intervention package; 634 before and 592 after the comprehensive intervention package). Both packages increased use of any contraceptive method, but the comprehensive approach also increased use of more effective methods. Odds ratios for consistent and correct use of condoms were 2.32 (95% confidence interval 1.55-3.46) and 2.78 (1.81-4.26), respectively, compared with the simple package. The rates of unwanted pregnancies and repeat abortions were somewhat reduced for both packages, with no significant statistical difference between them.

Conclusion: Couples who received the comprehensive post-abortion FP service appear to use more effective contraceptive methods and show better compliance.
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http://dx.doi.org/10.1080/13625180802512994DOI Listing
February 2009

The need for integrating family planning and postabortion care in China.

Int J Gynaecol Obstet 2008 Nov 29;103(2):140-3. Epub 2008 Aug 29.

National Research Institute for Family Planning, Beijing, China.

Objective: To assess the need for integrating postabortion care with family planning services in China.

Method: We collected data from a clinic-based study of 24 abortion clinics in 3 large cities in China.

Results: There was a total of 287 (10.3%) high-risk abortions among the 2780 respondents, 974 (35%) of whom had had repeated abortions and 48.4% had had 2 abortions within 1 year; 63.7% of the current pregnancies resulted from not using contraceptives; 28.8% and 19.8% of these new pregnancies, respectively, were due to the failure of the rhythm or the withdrawal method; only 9.7% of the respondents consistently used condoms; and only 9.1% could identify the correct time of their first ovulation following an abortion.

Conclusion: Contraceptive neglect and the high rates of repeated and high-risk abortions call for the integration of postabortion care with family planning services in China.
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http://dx.doi.org/10.1016/j.ijgo.2008.06.013DOI Listing
November 2008

Infertility-related perceptions and responses and their associations with quality of life among rural chinese infertile couples.

J Sex Marital Ther 2008 ;34(3):248-67

Centre for Epidemiology and Biostatistics, School of Public Health, The Chinese University of Hong Kong, Shatin, Hong Kong.

An anonymous cross-sectional survey interviewed 192 infertile couples consulting a family planning clinic in rural China. Of them, over 30% believed that childless couples could not live well, 80% desired to have a child very badly, over 60% pressured themselves or spouse due to infertility, and over 50% felt pressured when having sex. Furthermore, 19.8% of men and 37.5% of women felt that infertility is humiliating for women. A multivariate analyses showed that a lower income, a worsened spousal relationship, infertility related perceptions, pressuring oneself or spouse due to infertility, and a strong desire for children were significantly associated with a lowered quality of life. Gender differences were also observed.
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http://dx.doi.org/10.1080/00926230701866117DOI Listing
May 2008

Bayesian Method for Continuous Cursor Control in EEG-Based Brain-Computer Interface.

Conf Proc IEEE Eng Med Biol Soc 2005;2005:7052-5

Institute for Infocomm Research, 21 Heng Mui Keng Terrace, Singapore 119613; Department of Electronic Science and Technology, USTC, Hefei, Anhui, China 230026. E-mail:

To develop effective learning algorithms for continuous prediction of cursor movement using EEG signals is a challenging research issue in Brain-Computer Interface (BCI). To train a classifier for continuous prediction, trials in training dataset are first divided into segments. The difficulty is that the actual intention (label) at each time interval (segment) is unknown. In this paper, we propose a novel statistical approach under Bayesian learning framework to learn the parameters of a classifier. To make use of all the training dataset, we iteratively estimate probability of the unknown label, and use this probability to assist the training process. Experimental results have shown that the performance of the proposed method is equal to or better than the best results so far.
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http://dx.doi.org/10.1109/IEMBS.2005.1616130DOI Listing
October 2012

Gender power and marital relationship as predictors of sexual dysfunction and sexual satisfaction among young married couples in rural China: a population-based study.

Urology 2006 Mar;67(3):579-85

Centre for Epidemiology and Biostatistics, School of Public Health, Chinese University of Hong Kong Faculty of Medicine, Hong Kong, China.

Objectives: To investigate associations between gender relationships and sexual dysfunction (SD) of younger married couples living in rural China.

Methods: An anonymous cross-sectional population-based survey study was conducted in a rural area in Hunan, China. A random sample of 298 couples were recruited. Self-reported SD, sexual satisfaction, and variables related to gender power and marital relationship were measured.

Results: Of the respondents, 28.2% and 45.6% of the husbands and wives were having at least one of the studied SDs, respectively. The results of the multivariate analyses showed that husbands not reporting a quality marital relationship (odds ratio [OR] 4.27, 95% confidence interval [CI] 2.13 to 8.57), who mistrusted their wives (OR 9.14, 95% CI 4.22 to 19.78), who claimed themselves as the decision-maker regarding condom use (OR 2.41, 95% CI 1.20 to 4.85), and whose wife scored lower in the relationship control subscale of the sexual relationship power scale (OR 2.83, 95% CI 1.15 to 6.95) were more likely than other husbands to have at least one SD. Wives who were not trusted by their husbands (OR 2.94, 95% CI 1.39 to 6.25), whose husbands were more powerful than they were in general decision-making (OR 1.98, 95% CI 1.14 to 3.43), and who scored lower in the relationship control subscale (OR 3.77, 95% CI 1.65 to 8.62) were more likely than other wives to have at least one SD.

Conclusions: Gender relationships, including the quality of the marital relationship, mutual trust, decision-making, and relationship control, were significantly associated with SD. Gender inequality has been observed and needs to be taken into account in promoting sexual health among married couples living in rural China.
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http://dx.doi.org/10.1016/j.urology.2005.09.039DOI Listing
March 2006

Prevalence and risk factors of sexual dysfunction among younger married men in a rural area in China.

Urology 2005 Sep;66(3):616-22

Chinese University of Hong Kong, Hong Kong, China.

Objectives: To investigate the prevalence and factors associated with sexual dysfunction (SD) among younger married men living in rural China.

Methods: An anonymous questionnaire was self-administered by the husbands of 298 randomly selected married women aged 20 to 39 years.

Results: Of all 298 respondents, 84 (28.8%) had at least one of the seven studied SDs. The prevalence of an individual SD ranged from 3.7% (physical pain) to 19.5% (premature ejaculation); 41.9% were dissatisfied with their sexual life. Age, education level, age at marriage, and income were, in general, not statistically significant in predicting SD. Adjusting for age, education level, and age at marriage, the following were significantly associated with different categories of SD: smoking, SD of the wife, perceived health status, mental health and vitality quality of life (QOL), sharing a bedroom with nonspouse family members, masturbation, and the perceived importance of sexual life. Income, the perceived importance of sexual life and adequate sexual knowledge, mental health QOL, inability to achieve climax, and erectile problems were independently associated with sexual satisfaction.

Conclusions: SD among younger married men in rural China was significantly associated with mental health QOL and vitality QOL. Other factors, such as perceived physical health, room sharing, and spousal SD, were also involved. Most respondents perceived their sexual knowledge to be inadequate, which was also associated with sexual satisfaction. Because various factors were significant in predicting SD, multiple approaches are required in promoting sexual health in this study population.
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http://dx.doi.org/10.1016/j.urology.2005.04.010DOI Listing
September 2005

Mifepristone-induced early abortion and outcome of subsequent wanted pregnancy.

Am J Epidemiol 2004 Jul;160(2):110-7

Key Laboratory of Contraceptive Drug and Device Research, Department of Reproductive Epidemiology and Social Science, Shanghai Institute of Planned Parenthood Research, Shanghai, China.

Follow-up information on subsequent pregnancies after mifepristone (RU486)-induced abortion is scarce. The authors examined whether one mifepristone-induced first-trimester abortion affects the outcome of a subsequent wanted pregnancy. In a study conducted in 1998-2001 at antenatal clinics in Beijing, Chengdu, and Shanghai, China, the authors enrolled 4,925 women with no history of induced abortion, 4,931 women with one previous mifepristone-induced abortion, and 4,800 women with one previous surgical abortion and followed them through pregnancy and childbirth. The adjusted odds ratio for preterm delivery in women with one mifepristone abortion compared with women with no abortion was 0.77 (95% confidence interval: 0.61, 0.98). Although the mean birth weight of infants born to women with mifepristone abortion was 33 g (95% confidence interval: 17, 49) higher than that of infants born to women with no abortion, the frequencies of low birth weight and mean lengths of pregnancy were similar. There were no significant differences in risk of preterm delivery, frequency of low birth weight, or mean infant birth weight in the comparisons of women with previous mifepristone abortion and women with surgical abortion. This study suggests that one early abortion induced by mifepristone in nulliparous women has no adverse effects on the outcome of a subsequent pregnancy.
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http://dx.doi.org/10.1093/aje/kwh182DOI Listing
July 2004
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