Publications by authors named "Yihua Lu"

27 Publications

  • Page 1 of 1

Optimization of the Radiation Dose of Digital Breast Tomosynthesis in Opportunistic Screening by Studying the Effect of Different Combinations of FFDM and DBT Views.

Int J Gen Med 2021 30;14:1147-1154. Epub 2021 Mar 30.

Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, Nantong, 226019, Jiangsu, People's Republic of China.

Background: Full-field digital mammography (FFDM) and digital breast tomosynthesis (DBT) are used separately or in combination to identify small breast lesions. The dose of the examination depends on the density of the breast and the imaging (FFDM or DBT) performed. We have performed a retrospective review of FFDM and DBT in women with denser breasts in order to demonstrate how varying the combination of FFDM and DBT in CC and MLO views affects lesion detection and the average gland dose.

Methods: Eighty-one patients with dense breast received both full-field digital mammography (FFDM) and DBT bilateral screening. The recorded data included the display rates for small lesions or other positive lesions, the type of breast gland, the average gland dose (AGD), and the compression thickness of different collection methods. ANOVA was used to compare the AGD among different collection combinations, and -test was used to perform pairwise comparison between groups with the same gland type. The relationship between AGD and compression thickness was analyzed by Pearson linear correlation, and the lesion display rates were compared using Chi-square test.

Results: We found that AGDs were significantly different among the 6 collection methods (F = 119.06, p<0.01), but were not obviously different between groups with the same gland type (F = 0.848, p>0.05). The types of dense glands were correlated with compression thickness, and the thickness was moderately to strongly correlated with AGD (r=0.596-0.736). The combination of single-view DBT(CC-DBT) and FFDM showed significantly higher mass display rates than the two-view FFDM (p<0.05), while the display rates for other positive lesions were similar (p>0.05).

Conclusion: Our study showed that in opportunistic screening of patients with small breast masses that can be easily detected by ultrasound, MLO-FFDM+CC-DBT or CC-FFDM+MLO-DBT combinations can better balance the individual average gland dose and detection accuracy. The study result cannot be applied to the detection of non-mass lesions as the numbers are too small.
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http://dx.doi.org/10.2147/IJGM.S300584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019607PMC
March 2021

A robust edge-based template matching algorithm for displacement measurement of compliant mechanisms under scanning electron microscope.

Rev Sci Instrum 2021 Mar;92(3):033703

Guangdong Key Laboratory of Precision Equipment and Manufacturing Technology, South China University of Technology, Guangzhou 510640, People's Republic of China.

This paper develops a robust edge-based template matching algorithm for displacement measurement of compliant mechanisms under a scanning electron microscope (SEM). The algorithm consists of three steps. First, the Sobel gradient operator and a self-adaptive segment strategy are used to establish the shape model in which the gradient directions of the object's edge points are calculated. Second, a similarity criterion based on image gradients that is robust to illumination change and image noise is utilized for template matching to obtain the coarse results. The third step is to refine the matching results by using an orientation-guided subpixel interpolation strategy. A series of simulations is conducted, and the results show that the proposed algorithm enjoys great robustness against strong image noise and gray-value fluctuation, as well as small rotations and background interferences, and thus is suitable for processing SEM images of compliant mechanisms. Finally, the application of the proposed algorithm in the measurement of the spring constant of the flexure hinges with a straight beam form under a SEM is demonstrated.
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http://dx.doi.org/10.1063/5.0023244DOI Listing
March 2021

Association of Serum Uric Acid, Urea Nitrogen, and Urine Specific Gravity Levels at 16-18 Weeks of Gestation with the Risk of Gestational Diabetes Mellitus.

Diabetes Metab Syndr Obes 2020 1;13:4689-4697. Epub 2020 Dec 1.

Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, People's Republic of China.

Objective: To evaluate the associations of serum uric acid (UA), urea nitrogen (UN), and urine specific gravity (USG) levels in the first trimester of pregnancy with the risk of gestational diabetes mellitus (GDM).

Patients And Methods: A retrospective cohort study was conducted in 1,769 pregnant women aged 31.55 ± 3.91 years. UA, UN, and USG levels were measured during the 16-18th week of gestation. GDM was diagnosed by an oral 75 g glucose tolerance test during the 24-28th week of gestation.

Results: A multivariate adjusted logistic regression analysis showed that UA levels in the highest quartile increased the risk of GDM by 55.7% (odds ratio [OR]: 1.557, 95% confidence interval [CI]: 1.055-2.298; = 0.026) compared to those in the lowest quartile. USG levels in the second, third, and fourth quartiles increased the risk of GDM by 67.6% (95% CI: 1.090-2.421), 112.4% (95% CI: 1.446-3.119), and 94.5% (95% CI: 1.314-2.880), respectively, compared to those in the first quartile ( trend = 0.001). No significant association between UN levels and the GDM risk was observed. When the extreme composite biomarker score quartiles were compared, the adjusted OR (95% CI) for GDM was 1.909 (95% CI: 1.332-2.736). Age-stratified analyses revealed similar results in women aged ≤35 years only, but not in those aged >35 years.

Conclusion: Higher levels of UA and USG and a higher composite kidney function biomarker score during the 16-18th week of gestation were positively and independently associated with an increased risk of GDM.
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http://dx.doi.org/10.2147/DMSO.S282403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718966PMC
December 2020

Pharmacokinetics and Tissue Distribution of Loratadine, Desloratadine and Their Active Metabolites in Rat based on a Newly Developed LC-MS/MS Analytical Method.

Drug Res (Stuttg) 2020 Nov 2;70(11):528-540. Epub 2020 Sep 2.

Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, Nanjing, P. R. China.

Loratadine (LOR) and its major metabolite, desloratadine (DL) are new-generation antihistamines. The hydroxylated metabolites of them, 6-OH-DL, 5-OH-DL and 3-OH-DL are also active because of their ability to inhibit binding of pyrilamine to brain H receptors and a tendency for distributing to specific immune-regulatory tissues. In this study, a new validated LC-MS/MS method to simultaneously quantify LOR, DL, 6-OH-DL, 5-OH-DL and 3-OH-DL in plasma and tissues was established and applied to an investigation of their pharmacokinetics and target-tissue distribution tendency for the first time. Pharmacokinetics parameters in rat were measured and the results suggest that the body's exposure to active metabolites were much higher than to the prodrug with LOR, but much lower with DL. The tissue distribution study shows that LOR, DL and their active metabolites were widely distributed in the liver, spleen, thymus, heart, adrenal glands and pituitary gland. For immune-regulatory tissues, the concentrations of LOR, DL and their active metabolites in the spleen were much higher than in the thymus, which is related to the spleen, one of the sites where immune responses occur. LOR and its metabolites might inhibit immune-mediated allergic inflammation through the hypothalamic-pituitary-adrenal (HPA) axis. It was also found that the concentration of LOR in the heart was highest after liver and adrenal glands while those of DL, 6-OH-DL and 5-OH-DL in the liver, adrenal glands and spleen were all higher than those in the heart, which suggests that LOR may have a greater tendency to distribute in the heart than its metabolites.
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http://dx.doi.org/10.1055/a-1233-5575DOI Listing
November 2020

Effect of graphene quantum dot size on plant growth.

Nanoscale 2020 Jul 20;12(28):15045-15049. Epub 2020 May 20.

Shenzhen Institute of Artificial Intelligence and Robotics for Society (AIRS), Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), 14-15F, Tower G2, Xinghe World, Rd Yabao, Longgang District, Shenzhen 518172, China.

We found a straightforward dependence of plant growth on the sizes of graphene quantum dots. Enormous GQDs, such as graphene with dimensions of micrometers, neither promoted nor inhibited the growth. In contrast, synthesized GQDs with dimensions of about 10 nm best promoted the plant growth. Moreover GQDs synthesized using an "intelligent" chemistry robot yielded even better growth results than did GQDs synthesized conventionally by humans. In addition, a theoretical model was derived for the mechanism of the promotion of plant growth by GQDs.
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http://dx.doi.org/10.1039/d0nr01913eDOI Listing
July 2020

Toward "On-Demand" Materials Synthesis and Scientific Discovery through Intelligent Robots.

Adv Sci (Weinh) 2020 Apr 3;7(7):1901957. Epub 2020 Feb 3.

Shenzhen Institute of Artificial Intelligence and Robotics for Society (AIRS) The Chinese University of Hong Kong Shenzhen Guangdong 518172 China.

A Materials Acceleration Operation System (MAOS) is designed, with unique language and compiler architecture. MAOS integrates with virtual reality (VR), collaborative robots, and a reinforcement learning (RL) scheme for autonomous materials synthesis, properties investigations, and self-optimized quality assurance. After training through VR, MAOS can work independently for labor and intensively reduces the time cost. Under the RL framework, MAOS also inspires the improved nucleation theory, and feedback for the optimal strategy, which can satisfy the demand on both of the CdSe quantum dots (QDs) emission wavelength and size distribution quality. Moreover, it can work well for extensive coverages of inorganic nanomaterials. MAOS frees the experimental researchers out of the tedious labor as well as the extensive exploration of optimal reaction conditions. This work provides a walking example for the "On-Demand" materials synthesis system, and demonstrates how artificial intelligence technology can reshape traditional materials science research in the future.
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http://dx.doi.org/10.1002/advs.201901957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141037PMC
April 2020

Lithium Clustering during the Lithiation/Delithiation Process in LiFePO Olivine-Structured Materials.

ACS Omega 2019 Dec 25;4(24):20612-20617. Epub 2019 Nov 25.

Shenzhen Institute of Artificial Intelligence and Robotics for Society (AIRS), The Chinese University of Hong Kong, Shenzhen, 14-15F, Tower G2, Xinghe World, Rd Yabao, Longgang District, Shenzhen 518172, P. R. China.

Olivine-structured LiFePO is one of the most popular cathode materials in lithium-ion batteries (LIBs) for sustainable applications. Significant attention has been paid to investigating the dynamics of the lithiation/delithiation process in Li FePO (0 ≤ ≤ 1), which is crucial for the development of high-performance LiFePO material. Various macroscopic models based on experimental evidence have been proposed to explain the mechanism of phase transition from LiFePO to FePO, such as the shrinking core (i.e., core-shell) model, Laffont's (i.e., new core-shell) model, domino-cascade model, phase transformation wave, solid solution model, many-particle models, etc. However, these models, unfortunately, contradict each other and their validity is still under debate. An atomistic model is urgently required to depict the lithiation/delithiation process in Li FePO. In this article, we reveal the lithiation/delithiation process in LiFePO simulated by a computational model using the generalized gradient approximation (GGA + ) method. We find that the clustered configuration is the most energetically favorable, leading to co-operative Jahn-Teller distortion among the inter-polyhedrons that can be observed clearly from the bond patterns. This atomistic model not only offers answers to experimental results obtained at moderate or high rates but also gives the direction to further improve the rate capability of LiFePO cathode material for high-power LIBs.
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http://dx.doi.org/10.1021/acsomega.9b02694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906779PMC
December 2019

A magnification-continuous calibration method for SEM-based nanorobotic manipulation systems.

Rev Sci Instrum 2019 May;90(5):053706

Guangdong Key Laboratory of Precision Equipment and Manufacturing Technology, School of Mechanical and Automotive Engineering, South China University of Technology, Guangzhou 510640, People's Republic of China.

Calibration for scanning electron microscope (SEM) based nanorobotic manipulation systems is important and difficult. Most current calibration methods are cumbersome because they require customized high precision calibration boards and repeated calibration procedures in different magnifications. This paper presents a convenient magnification-continuous calibration method with high precision for SEM-based nanorobotic manipulation systems. The projection matrix containing a continuous magnification factor is obtained by modifying the affine camera model. This facilitates the simplification of the parameter computing process. Movement features are used to align the moving axes of micropositioning stages and calibrate the system, which benefits for the realization of efficient automatic calibration. Three experiments are carried out, and the results demonstrate that the proposed method is effective and practical for calibrating SEM-based nanorobotic manipulation systems under a wide range of continuous magnifications. Experiments also confirm that high precision measurements can be conducted in different magnifications with only once calibration and the relative error is within 1%.
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http://dx.doi.org/10.1063/1.5086940DOI Listing
May 2019

Using path analysis to investigate the relationships between depression, anxiety, and health-related quality of life among patients with coronary artery disease.

Qual Life Res 2019 Oct 16;28(10):2695-2704. Epub 2019 May 16.

Department of Cardiovascular Surgery, Nantong Rich Hospital, Nantong, 226010, People's Republic of China.

Purpose: Demographic and clinical indicators usually influence depression, anxiety, and health-related quality of life (HRQoL) in patients with coronary artery disease (CAD). The aim of this study was to assess the direct and indirect association that existed among the identified variables, psychosocial status, and HRQoL in CAD patients.

Methods: CAD patients with at least one of the main coronary artery and/or branch stenosis over 50% were eligible for inclusion. HRQoL, depression, and anxiety were tested by questionnaires within 3 days after angiography. Mono-factor and multiple linear regression models were used to examine the independent associations of depression, anxiety, and HRQoL. A path analysis was conducted to examine the association among demographic/clinical indicators, depression, anxiety, and HRQoL.

Results: The sample consisted of 414 subject, patients with depression accounted for 40.82%, and patients with anxiety accounted for 25.12%. The direct effects of SAS scores on HRQoL (B = - 0.26, β = - 0.16), of SDS scores on HRQoL (B = - 0.70, β = - 0.47), of gender on HRQoL (B = 4.05, β = 0.17), and of NYHA classification on HRQoL (B = - 3.46, β = - 0.18) were significant (p < 0.001). The indirect effects of gender on HRQoL (B = 2.16, β = 0.09) and of Gensini scores on HRQoL (B = - 0.06, β = - 0.08) were also statistically significant (p < 0.001).

Conclusions: Depression and anxiety were common CAD patients and played an important role in HRQoL. Gender differences were found in determinants of HRQoL and the state of depression and anxiety directly, and women's anxiety, depression, and quality of life were worse than men's. NYHA classification and Gensini scores also played direct and indirect role in HRQoL, respectively.
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http://dx.doi.org/10.1007/s11136-019-02207-8DOI Listing
October 2019

Functional variant of the carboxypeptidase M (CPM) gene may affect silica-related pneumoconiosis susceptibility by its expression: a multistage case-control study.

Occup Environ Med 2019 03 23;76(3):169-174. Epub 2019 Jan 23.

Jiangsu Provincial Key Laboratory of Geriatrics, Department of Geriatrics, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.

Objectives: In a genome-wide association study, we discovered chromosome 12q15 (defined as rs73329476) as a silica-related pneumoconiosis susceptibility region. However, the causal variants in this region have not yet been reported.

Methods: We systematically screened eight potentially functional single-neucleotide polymorphism (SNPs) in the genes near rs73329476 (carboxypeptidase M () and cleavage and polyadenylation specific factor 6 ()) in a case-control study including 177 cases with silicosis and 204 healthy controls, matched to cases with years of silica dust exposure. We evaluated the associations between these eight SNPs and the development of silicosis. Luciferase reporter gene assays were performed to test the effects of selected SNP on the activity of in the promoter. In addition, a two-stage case-control study was performed to investigate the expression differences of the two genes in peripheral blood leucocytes from a total of 64 cases with silicosis and 64 healthy controls with similar years of silica dust exposure as the cases.

Results: We found a strong association between the mutant rs12812500 G allele and the susceptibility of silicosis (OR=1.45, 95% CI 1.03 to 2.04, p=0.034), while luciferase reporter gene assays indicated that the mutant G allele of rs12812500 is strongly associated with increased luciferase levels compared with the wild-type C allele (p<0.01). Moreover, the mRNA (peripheral blood leucocytes) expression of the gene was significantly higher in subjects with silicosis compared with healthy controls.

Conclusions: The rs12812500 variant of the gene may increase silicosis susceptibility by affecting the expression of , which may contribute to silicosis susceptibility with biological plausibility.
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http://dx.doi.org/10.1136/oemed-2018-105545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581105PMC
March 2019

Superbound Excitons in 2D Phosphorene Oxides.

Authors:
Yihua Lu Xi Zhu

J Phys Chem A 2019 Jan 18;123(1):21-25. Epub 2018 Dec 18.

School of Science and Engineering , Chinese University of Hong Kong Shenzhen , Shenzhen , Guangdong 518172 , China.

The optical excitations in layered phosphorene oxides are studied via ab initio calculation together with GW approximation for the self-energy and solving the Bethe-Salpeter equation (BSE) for the excitations. It is found that the electronic structure of phosphorene oxides closely depends on the oxygen concentration. For the high oxygen coverage structure PO, it shows a strong localized molecular-like electronic structure with exciton binding ( E) energy up to 3.0 eV, which is several times larger than the ordinary E value in various low-dimensional materials. This study may provide an alternative way to design functional layered materials with large exciton binding energies by controlling the oxidation level in phosphorene oxides.
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http://dx.doi.org/10.1021/acs.jpca.8b09683DOI Listing
January 2019

AIR-Chem: Authentic Intelligent Robotics for Chemistry.

J Phys Chem A 2018 Nov 13;122(46):9142-9148. Epub 2018 Nov 13.

Hefei National Laboratory for Physical Sciences at Microscale, Collaborative Innovation Center of Chemistry for Energy Materials , University of Science and Technology of China , Hefei , Anhui 230026 , China.

The new era with prosperous artificial intelligence (AI) and robotics technology is reshaping the materials discovery process in a more radical fashion. Here we present authentic intelligent robotics for chemistry (AIR-Chem), integrated with technological innovations in the AI and robotics fields, functionalized with modules including gradient descent-based optimization frameworks, multiple external field modulations, a real-time computer vision (CV) system, and automated guided vehicle (AGV) parts. AIR-Chem is portable and remotely controllable by cloud computing. AIR-Chem can learn the parametric procedures for given targets and carry on laboratory operations in standalone mode, with high reproducibility, precision, and availability for knowledge regeneration. Moreover, an improved nucleation theory of size focusing on inorganic perovskite quantum dots (IPQDs) is theoretically proposed and experimentally testified to by AIR-Chem. This work aims to boost the process of an unmanned chemistry laboratory from the synthesis of chemical materials to the analysis of physical chemical properties, and it provides a vivid demonstration for future chemistry reshaped by AI and robotics technology.
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http://dx.doi.org/10.1021/acs.jpca.8b10680DOI Listing
November 2018

A Novel Variant of Desmoplakin Is Potentially Associated with Silicosis Risk.

DNA Cell Biol 2018 Nov 12;37(11):925-931. Epub 2018 Sep 12.

1 School of Public Health, Nantong University , Nantong, China .

Two genome-wide association studies and one sequencing study have coincidently reported significant associations of single nucleotide polymorphisms (SNPs) in the desmoplakin (DSP) gene with the risk of pulmonary fibrosis (mainly idiopathic pulmonary fibrosis). However, these findings have not been well generalized to occupational pulmonary fibrosis (e.g., silica-related silicosis). We systematically genotyped 8 potentially functional SNPs and the previously reported rs2076295 and rs2744371 in DSP gene region and evaluated the associations between these 10 SNPs and silicosis risk in a case-control study that included 177 silicosis cases and 204 controls with similar numbers of silica dust exposure years as the cases from a Chinese population. Genotyping was performed using the improved multiligase detection reaction multiplex SNP genotyping system. The variant A allele of rs2076304 exhibited significant association with the risk of silicosis (odds ratio = 1.53, 95% confidence interval = 1.03-2.29, p = 0.036). Moreover, significant association was observed between different genotypes of rs2076304 and DSP expression (p = 1.1 × 10) in 383 normal lung tissues. Further functional annotation indicated that the rs2076304 might influence the binding of RHOXF1. The rs2076304 in DSP gene is associated with a significantly increased risk of silicosis in a Han Chinese population. Further studies are warranted to validate and extend our findings, especially the biological mechanisms of rs2076304 in silicosis susceptibility.
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http://dx.doi.org/10.1089/dna.2018.4370DOI Listing
November 2018

The rs2609255 polymorphism in the FAM13A gene is reproducibly associated with silicosis susceptibility in a Chinese population.

Gene 2018 Jun 3;661:196-201. Epub 2018 Apr 3.

School of Public Health, Nantong University, Nantong, China. Electronic address:

Background: Two recent genome-wide association studies (GWASs) reported that the FAM13A gene at the 4q22 locus associated with pulmonary fibrosis (defined by rs2609255) overlapping with COPD (defined by rs6837671). We hypothesized that single-nucleotide polymorphisms (SNPs) related to lung disease (especially pulmonary fibrosis) identified in this region are also associated with the risk of silicosis.

Methods: To test this hypothesis, we genotyped these two SNPs (rs2609255 and rs6837671) in a case-control study including 177 silicosis cases and 204 controls with silica dust exposure years similar to the levels for cases in a Chinese population.

Results: We found that rs2609255 was significantly associated with increased silicosis risk (dominant model: OR = 1.71; 95% CI = 1.01-2.92; P = 0.047). Additionally, eQTL analysis based on the GTEx database indicated that the rs2609255 polymorphism may alter the expression level of FAM13A in lung tissues (P = 1.8 × 10). Furthermore, interaction analyses showed that rs2609255 interacts multiplicatively with years of silica dust exposure to contribute to silicosis risk (interaction P = 0.040).

Conclusions: These results indicate that rs2609255 may modify silicosis susceptibility in the Chinese population.
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http://dx.doi.org/10.1016/j.gene.2018.03.098DOI Listing
June 2018

Association of aspartic acid repeat polymorphism in the asporin gene with osteoarthritis of knee, hip, and hand: A PRISMA-compliant meta-analysis.

Medicine (Baltimore) 2018 Mar;97(12):e0200

Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu Province.

Objective: Several human studies have been conducted to explore the association between aspirin (ASPN) D-repeat polymorphisms and OA susceptibility, but these provide inconsistent results. Our primary aim is to examine whether D-repeat polymorphisms are related to OA risk.

Methods: We conducted a meta-analysis to investigate the association between ASPN D-repeat polymorphisms and OA. Electronic database was searched, including PubMed, Embase, CNKI, Ovid, and the reference lists of relevant articles published from the inception to January 24, 2018. The included studies were assessed in the following allele model: D14 allele versus others combined, D13 allele versus others combined, D15 allele versus others combined, and D14 allele versus D13 allele. Female population was also analyzed separately.

Results: Eleven articles (12 comparisons) with 4975 patients of knee, hip, and/or hand OA and 3754 controls were considered in this meta-analysis. For the D13 allele, OR and 95% CI in combined population indicated an borderline association (odds ratio [OR] = 0.94, confidence interval [CI]: 0.89-0.99, P = .027). No significant association between OA and the D14 allele and D15 allele in all pooled studies were observed.

Conclusion: Our result based on previously published studies demonstrated that the ASPN D13 allele was a protective factor for OA of knee, hip, and hand. For D14 and D15 allele, our present meta-analysis did not demonstrate statistically significant association. Further studies with larger sample size would be required.
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http://dx.doi.org/10.1097/MD.0000000000010200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895348PMC
March 2018

RAGE may act as a tumour suppressor to regulate lung cancer development.

Gene 2018 Apr 5;651:86-93. Epub 2018 Feb 5.

Jiangsu Provincial Key Laboratory of Geriatrics, Department of Geriatrics, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China. Electronic address:

Although the correlation of the RAGE rs2070600 polymorphism and cancer risk has been confirmed, detailed studies with functional and experimental evaluations are lacking. In this study, we first aimed to examine whether this polymorphism is associated with cancer risk based on the latest published data, and consistent with previous meta-analyses, a significant association between the rs2070600 polymorphism and cancer risk was observed (A versus G: OR = 1.25; 95% CI = 1.12-1.40). In additional stratified analyses based on cancer type, rs2070600 was significantly associated with an increased risk of lung cancer (A versus G: OR = 1.20; 95% CI = 1.09-1.33). Moreover, TCGA database showed that the expression level of RAGE was significantly lower in lung cancer tumour tissues than in adjacent non-tumour tissues, which was validated in the GEO database. Additionally, eQTL analysis indicated that the rs2070600 polymorphism may modify the expression level of RAGE in lung squamous cell carcinoma tissues (P = 0.09). Finally, we performed functional experiments in lung cancer cells and preliminarily demonstrated that RAGE may act as a tumour suppressor in lung cancer development. These findings provide evidence that the variant A allele of rs2070600 may decrease the expression of the tumour suppressor gene RAGE, thereby increasing lung cancer risk.
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http://dx.doi.org/10.1016/j.gene.2018.02.009DOI Listing
April 2018

Micro-motion detection of the 3-DOF precision positioning stage based on iterative optimized template matching.

Appl Opt 2017 Dec;56(34):9435-9443

This study presents a method for micro-motion detection of the three-degrees-of-freedom (3-DOF; x, y, θ) precision positioning stage (PPS) based on iterative optimized template matching (IOTM). In this method, a micro-vision system (MVS) is constructed and employed to capture magnified images of the measured PPS's surface with high quality. In addition, an efficient and accurate IOTM algorithm, which includes a pyramid hierarchical matching step for generating the initial guess and an iterative searching step for 3-DOF fine matching, is proposed to detect the micro-motion of the 3-DOF PPS. The simulation results show that the locating accuracy of the translation component (TC) and rotation component of this algorithm can respectively reach 0.01 pixels and 0.01 deg when the image quality is high and the initial guess is close to the real location. Measurement tests of a nano-PPS verify that the proposed method is practical and effective for 3-DOF micro-motion detection and the absolute accuracy of the TC of the MVS can easily reach the nanometer level.
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http://dx.doi.org/10.1364/AO.56.009435DOI Listing
December 2017

The reliability and validity of a new professionalism assessment scale for young health care workers.

Medicine (Baltimore) 2017 Jun;96(25):e7058

President's Office Department of Radiology Department of Scientific Research and Teaching, The Second Affiliated Hospital of Nantong University Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, Nantong, Jiangsu, China.

With the development of medical technique, many medical challenges have been solved. This cross-sectional study was aimed to assess the reliability and validity of a new developed scale for assessing the professionalism of young health care workers.This cross-sectional population-based study was conducted based on cluster sampling method in 2015. The participants were from 2 medical centers of Nantong city of Jiangsu province in China. The internal consistency reliability was assessed using Cronbach's alpha and split-half reliability coefficients. Construct validity was analyzed using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). Content, convergent, and discriminant validities were also assessed in this study.Total 749 individuals aged 29.09 ± 3.91 years old participated in this investigation. There were 745 valid questionnaires and 730 were complete. Cronbach's alpha value (0.944) and the split-half reliability coefficient (0.873) reflected satisfactory internal consistency reliability of this new professionalism assessment scale. EFA extracted a 7-factor model. About 63.4% of the total variance was explained by these factors. However, CFA showed a good model fit after excluding the items with factor loading lower than 0.5. Good discriminant validity of this new developed professionalism assessment scale was also shown (P < .05). However, the evidences for content and convergent validity were not enough in this study.The results showed the satisfactory reliability of this new developed professionalism assessment scale. However, this scale should be modified to improve the validity in further studies.
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http://dx.doi.org/10.1097/MD.0000000000007058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484190PMC
June 2017

HIV-1 CRF01_AE strain is associated with faster HIV/AIDS progression in Jiangsu Province, China.

Sci Rep 2017 05 8;7(1):1570. Epub 2017 May 8.

Department of Epidemiology and Biostatistics, School of Public Health, Nantong University, Nantong, Jiangsu, China.

The goal of this study was to assess risk factors associated with HIV/AIDS progression. Between May 2007 and December 2014, 114 subjects were enrolled in Wuxi City and examined every 6 months. The pol gene sequence was amplified to ascertain the HIV-1 subtype. A Cox proportional hazards regression model was used to estimate the factors associated with HIV/AIDS progression. The median follow-up time for all 114 subjects was 26.70 months (IQR: 18.50-41.47), while the median progression time of the 38 progressed subjects was 24.80 months (IQR: 14.13-34.38). Overall, the CRF01_AE subtype was correlated with a significant risk of accelerated progression compared to non-CRF01_AE subtypes (HR = 3.14, 95%CI: 1.39-7.08, P = 0.006). In addition, a lower CD4 count (350-499) at baseline was associated with a risk of accelerated HIV/AIDS progression compared to higher CD4 count (≥500) (HR = 4.38, 95%CI: 1.95-9.82, P < 0.001). Furthermore, interaction analyses showed that HIV-1 subtypes interacted multiplicatively with transmission routes or CD4 count at baseline to contribute to HIV/AIDS progression (P = 0.023 and P < 0.001, respectively). In conclusion, the CRF01_AE subtype and a lower CD4 count at baseline tend to be associated with the faster progression of HIV/AIDS. Understanding the factors affecting HIV/AIDS progression is crucial for developing personalized management and clinical counselling strategies.
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http://dx.doi.org/10.1038/s41598-017-01858-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431509PMC
May 2017

Body mass index and hand osteoarthritis susceptibility: an updated meta-analysis.

Int J Rheum Dis 2016 Dec 5;19(12):1244-1254. Epub 2016 Nov 5.

Department of Statistics, Public Health College Nantong University, Nantong, Jiangsu Province, China.

Aim: Numerous epidemiologic studies have evaluated the association between overweight and hand osteoarthritis; However, the existing results are inconsistent.

Methods: Systematic searches were performed and reference lists from the retrieved trials were searched. This meta-analysis and meta-regression was executed to identify all English-language articles that quantitatively assess the strength of associations between body mass index and hand osteoarthritis risk. Study-specific incremental estimates were standardized to determine the risk associated with a 5 kg/m increase in body mass index. We conducted the study according to the guidelines for the meta-analysis of observational studies in epidemiology.

Results: Of the 21 studies included, 13 were cross-sectional studies, three were case control studies and five were cohort studies. The pooled summary estimates were 1.10 (95%CI: 0.98-1.24) with no significant difference (P = 0.09). Subgroup analysis shows that body mass index was positively associated with hand osteoarthritis in cross-sectional studies (1.05 [95%CI: 1.02-1.08] P < 0.01), while with no significant difference was found in case-control studies (1.28 [95%CI: 0.87-1.88]) and in cohort studies (1.06 [95%CI: 0.71-1.58]) (P = 0.21 and P = 0.77, respectively). A weak but significant effect on radiographic hand osteoarthritis risk was found. The summary estimates were 1.06 (95%CI: 1.02-1.10) in studies defined by radiography and 1.25 (95%CI: 1.06-1.49) by radiography and clinically (P < 0 .01 and P = 0.01, respectively).

Conclusion: It appears that increased body mass index contributes to a positively moderate effect on susceptibility to hand osteoarthritis, as defined radiographically and/or radiographically and clinically. The effects vary by study design and osteoarthritis definition.
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http://dx.doi.org/10.1111/1756-185X.12895DOI Listing
December 2016

Coronary Artery Disease in Premenopausal and Postmenopausal Women.

Int Heart J 2017 Apr 17;58(2):174-179. Epub 2017 Mar 17.

Department of Epidemiology, School of Public Health, Nantong University.

The purpose was to determine the differences between premenopausal and postmenopausal coronary artery disease (CAD) risk factors, clinical manifestation, cardiovascular features, rates of recurrence, and influencing factors.Premenopausal (n = 57) and postmenopausal (n = 178) CAD women hospitalized during the same period were enrolled. All patients were followed-up, and the combined recurrence of major adverse cardiovascular events was recorded as the clinical outcome. Differences were compared between the 2 groups.Fewer premenopausal women suffered from hypertension (43.86% versus 75.28%, P < 0.001), type 2 diabetes (12.28% versus 35.96%, P = 0.001), and hyperlipidemia (5.26% versus 34.83%, P < 0.001), but more had a positive family history of premature CAD (40.35% versus 25.28%, P = 0.03). Acute coronary syndrome (ACS) was more frequently seen in premenopausal women (82.46% versus 48.88%, P < 0.001), and their left anterior descending branch was the vessel most often involved (65.33%). The cumulative recurrence rate was 1.76 times higher in postmenopausal patients than premenopausal patients. Clinical diagnosis (HR = 2.54, 95%CI: 1.21-4.85, P = 0.02) and type 2 diabetes (HR = 4.10, 95%CI: 2.37-8.83, P = 0.004) were two factors that influenced recurrence in premenopausal subjects, while the clinical diagnosis (HR = 1.93, 95%CI: 1.59-3.46, P = 0.03) and Gensini score (HR = 1.20, 95%CI: 1.11-1.45, P = 0.02) were influencing factors in the postmenopausal patients.Symptoms among younger women were atypical, but the onset of disease was faster and more urgent, and angiography in premenopausal women might underestimate the severity of disease. The risk factors, rate of recurrence, and influencing factors were different between premenopausal and postmenopausal patients.
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http://dx.doi.org/10.1536/ihj.16-095DOI Listing
April 2017

Quantitative assessment of polymorphisms in H19 lncRNA and cancer risk: a meta-analysis of 13,392 cases and 18,893 controls.

Oncotarget 2016 Nov;7(48):78631-78639

Department of Epidemiology and Biostatistics, School of Public Health, Nantong University, Nantong, Jiangsu, China.

H19 refers to a long non-coding RNA (lncRNA) that functions as an oncogenic molecule in different cancer cells. Genetic variants of H19 may affect the activity of certain regulatory factors, which subsequently regulate the aberrant expression of H19. This feedback loop might be one of the underlying mechanisms influencing tumour susceptibility and prognosis. Although there have been several recent studies that examined possible links between polymorphisms in H19 and cancer risk, the results have been inconclusive. Thus, we performed a meta-analysis to estimate the associations between H19 polymorphisms (rs2107425, rs2839698 and rs217727) and cancer risk. Ten studies comprising 13,392 cases and 18,893 controls were included in the study. Overall, the variant T allele of rs2107425 correlated with a significantly decreased risk of developing cancer (dominant model: OR = 0.86; 95% CI = 0.76-0.98). In addition, a marginally significant association between the rs2839698 and cancer risk was observed (dominant model: OR = 1.09; 95% CI = 0.99-1.20). After stratification for ethnicity, it became apparent that Asians with the variant A allele of rs2839698 exhibited a significantly higher risk of developing cancer (dominant model: OR = 1.11; 95% CI = 1.01-1.23). Interestingly, the rs2839698 variant was also significant associated with an increased risk of cancers of the digestive system (dominant model: OR = 1.23; 95% CI = 1.08-1.41). These findings provided evidence that H19 rs2107425 may modify general cancer susceptibility, while rs2839698 may modify cancer susceptibility based on ethnicity and type. Further experimental studies to evaluate the limits of this hypothesis are warranted, and future functional studies are required to clarify the possible mechanisms.
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http://dx.doi.org/10.18632/oncotarget.12530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346665PMC
November 2016

A comprehensive validation of HBV-related acute-on-chronic liver failure models to assist decision-making in targeted therapeutics.

Sci Rep 2016 09 16;6:33389. Epub 2016 Sep 16.

Department of Epidemiology and Medical Statistics, Nantong University, Nantong, China.

This research utilized an external longitudinal dataset of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) to compare and validate various predictive models that support the current recommendations to select the most effective predictive risk models to estimate short- and long-term mortality and facilitate decision-making about preferable therapeutics for HBV-ACLF patients. Twelve ACLF prognostic models were developed after a systematic literature search using the longitudinal data of 232 HBV-ACLF patients on the waiting list for liver transplantation (LT). Four statistical measures, the constant (A) and slope (B) of the fitted line, the area under the curve (C) and the net benefit (D), were calculated to assess and compare the calibration, discrimination and clinical usefulness of the 12 predictive models. According to the model calibration and discrimination, the logistic regression models (LRM2) and the United Kingdom model of end-stage liver disease(UKELD) were selected as the best predictive models for both 3-month and 5-year outcomes. The decision curve summarizes the benefits of intervention relative to the costs of unnecessary treatment. After the comprehensive validation and comparison of the currently used models, LRM2 was confirmed as a markedly effective prognostic model for LT-free HBV-ACLF patients for assisting targeted and standardized therapeutic decisions.
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http://dx.doi.org/10.1038/srep33389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025883PMC
September 2016

Fire-Needle Moxibustion for the Treatment of Knee Osteoarthritis: A Meta-Analysis.

Evid Based Complement Alternat Med 2016 15;2016:1392627. Epub 2016 Jun 15.

Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu 226009, China.

Objectives. The aim of this study was to evaluate the effectiveness of fire-needle moxibustion as an intervention in the treatment of knee osteoarthritis (KOA). Methods. An updated meta-analysis of randomized controlled trials (RCTs) on fire-needle moxibustion in treating KOA was conducted by searching PubMed, Embase, the Cochrane Library, Web of Science, Wanfang database, and the Chinese Medical Database (CNKI) since their inception through March 2016. The meta-analysis was performed using RevMan 5.3. Results. Thirteen RCTs were identified in the systematic study which consisted of 1179 participants. Fire-needle moxibustion treatment group had a statistical significance on recovery rate as well as recovery and marked-improvement rate compared with control group. Subgroup analysis indicated that there was significant difference between fire-needle moxibustion group and control group. However, GRADE analysis indicated that the quality of evidence for all outcomes was relatively low. Only two of 13 studies reported adverse reactions (difficulty in movement and intolerance of cold). Conclusion. This meta-analysis suggests that fire-needle moxibustion is more effective than control group in symptom management of KOA. Further high quality trials should be conducted to evaluate the effectiveness of fire-needle moxibustion on KOA.
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http://dx.doi.org/10.1155/2016/1392627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925950PMC
July 2016

Quantitative Assessment of the Polymorphisms in the HOTAIR lncRNA and Cancer Risk: A Meta-Analysis of 8 Case-Control Studies.

PLoS One 2016 24;11(3):e0152296. Epub 2016 Mar 24.

Department of Epidemiology and Biostatistics, School of Public Health, Nantong University, Nantong, Jiangsu, China.

HOX transcript antisense intergenic RNA (HOTAIR) is a long non-coding RNA (lncRNA) that functions as an oncogenic molecule in different cancer cells. Genetic variants of HOTAIR may affect the activity of certain regulatory factors and further regulate the aberrant expression of HOTAIR, which might be underlying mechanisms that affect tumour susceptibility and prognosis. Recently, several studies have been performed to examine the possible link between polymorphisms in HOTAIR and cancer risk; however, the results have been inconclusive. Therefore, we performed a meta-analysis to estimate the associations between HOTAIR polymorphisms (rs920778, rs4759314 and rs1899663) and cancer risk. Eight studies comprising 7,151 cases and 8,740 controls were included in our study. Overall, no significant associations between the HOTAIR polymorphisms (rs920778, rs4759314 and rs1899663) and cancer risk were observed. However, in further stratified analyses, the variant T allele of rs920778 exhibited a significant increased risk of developing digestive cancers (dominant model: OR = 1.44; 95% CI = 1.31-1.59). These findings provided evidence that HOTAIR rs920778 may modify the susceptibility to certain cancer types. Further studies incorporating subjects with different ethnic backgrounds combined with re-sequencing of the marked region and functional evaluations are warranted.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152296PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806879PMC
August 2016

A cross-sectional survey on the health status and the health-related quality of life of the elderly after flood disaster in Bazhong city, Sichuan, China.

BMC Public Health 2015 Feb 19;15:163. Epub 2015 Feb 19.

The Kirby Institute, the University of New South Wales, Sydney, Australia.

Background: Flood is common in China and causes extensive loss of property and human lives. Elderly is a vulnerable population prone to the detrimental impacts of floods. This survey aims to investigate the health status and the HRQoL of the elderly in Bazhong city after a major flood in 2011.

Methods: A total of 1183 elderly (aged > 60) were surveyed through random sampling from eight villages in Bazhong city. Two-week healthcare-seeking rate and chronic diseases prevalence were recorded anonymously. Health-related quality of life (HRQoL) was measured by the Medical Outcomes Study Short Form-36 (MOS SF-36). Multivariate regression analysis was conducted to determine the associated factors of poor HRQoL.

Results: The two-week healthcare-seeking rate among post-flood Bazhong elderly was significantly higher than the references rate among rural elderly in Sichuan province (59.3% versus 55.7%, χ2 = 5.134, p = 0.013), but Bazhong elderly demonstrated a significantly lower prevalence of chronic disease (33.2% versus 44.4%, χ2 = 48.847, p < 0.001). All dimension scores among Bazhong elderly were significantly lower than the references scores in rural Sichuan elderly. The determinants of poor physical health included older age, singlehood, poor sleep patterns, and chronic diseases and so on.

Conclusions: A marked decline in health status among elderly in Bazhong after the 2011 flood. Post-flood management targeting elderly need to be sensitive to their age, gender, married status and status of chronic diseases.
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http://dx.doi.org/10.1186/s12889-015-1402-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359459PMC
February 2015

Plasma adiponectin levels in relation to prognosis in patients with angiographic coronary artery disease.

Metabolism 2012 Dec 11;61(12):1803-8. Epub 2012 Jul 11.

Division of Cardiology, Department of Medicine, Peking Union Medical College Hospital, PUMC, Chinese Academy of Medical Sciences, Beijing 100730, China.

Objective: The objective was to study the associations between adiponectin levels and cardiovascular adverse clinical outcomes in patients with angiographic coronary artery disease (CAD) within the Han Chinese population in Beijing.

Materials/methods: A total of 449 hospitalized patients with angiographic CAD who were Han Chinese in Beijing participated in the study. Plasma adiponectin levels were examined from blood samples using a type of unique enzyme-linked immunosorbent assay that was developed by our laboratory. All of the patients' clinical data, including previously identified cardiovascular risk factors, creatinine clearance and left ventricle ejection fraction, were recorded after admission, and patients were followed up for 19±8 months. The primary end-point was marked by the occurrence of major adverse cardiovascular events (MACE), which included death, targeted vascular revascularization, acute coronary syndrome, heart failure, and transient ischemic attack (TIA) / stroke.

Results: A total of 109 cases of MACE occurred: 15 cases of death, 66 cases of acute coronary syndrome, 4 cases of TIA/stroke, 6 cases of targeted vessel revascularization, and 18 cases of heart failure. Among all the patients, 173 were assigned to the high adiponectin group and 276 were assigned to the low adiponectin group according to their baseline plasma adiponectin levels. The incidence of MACE was significantly higher in the low adiponectin group (P=.037). In a multivariate Cox regression analysis for adiponectin levels, previously documented risk factors, coronary artery stenosis scores, and low adiponectin levels were indicated as independent predictors of MACE in patients with CAD (RR 1.75; 95% CI, 1.066-2.865; P=.027). Further adjustment for hsCRP, Ccr, LVEF, fasting glucose and lipid profile did not attenuate this association (RR=2.36; 95% CI 1.338-4.167; P=.003). The relative risk for low adiponectin levels after additional adjustment for the coronary score was 2.42 (95% CI 1.367-4.279; P=.002). The Kaplan-Meier survival analysis curve suggested that patients with lower adiponectin concentrations had a decreased event-free survival ratio (log-rank χ(2) =4.592, P=.032).

Conclusions: The results indicate a potential association between plasma adiponectin levels and cardiovascular prognosis in patients with CAD.
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http://dx.doi.org/10.1016/j.metabol.2012.06.001DOI Listing
December 2012