Yih-Leong Chang

Yih-Leong Chang

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Yih-Leong Chang

Publications by authors named "Yih-Leong Chang"

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Primary resistance to osimertinib despite acquired .

Respirol Case Rep 2020 Mar 5;8(2):e00532. Epub 2020 Feb 5.

Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan.

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http://dx.doi.org/10.1002/rcr2.532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002899PMC
March 2020

Clinical characteristics and treatment outcome of oropharyngeal squamous cell carcinoma in an endemic betel quid region.

Sci Rep 2020 Jan 16;10(1):526. Epub 2020 Jan 16.

Department of Pathology, National Taiwan University Hospital, National Taiwan University Cancer Center and National Taiwan University College of Medicine, Taipei, 10002, Taiwan.

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http://dx.doi.org/10.1038/s41598-019-57177-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965138PMC
January 2020

A Web-Based Virtual Microscopy Platform for Improving Academic Performance in Histology and Pathology Laboratory Courses: A Pilot Study.

Anat Sci Educ 2019 Dec 27. Epub 2019 Dec 27.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1002/ase.1940DOI Listing
December 2019

Clinical Outcomes of Up-front Surgery Versus Surgery After Induction Chemotherapy for Thymoma and Thymic Carcinoma: A Retrospective Study.

Clin Lung Cancer 2019 11 10;20(6):e609-e618. Epub 2019 Jul 10.

Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2019.06.011DOI Listing
November 2019

Impact of dysplastic surgical margins for patients with oral squamous cell carcinoma.

Oral Oncol 2019 Oct 31;97:1-6. Epub 2019 Jul 31.

Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 10002, Taiwan; Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei 10002, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13688375193025
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http://dx.doi.org/10.1016/j.oraloncology.2019.07.015DOI Listing
October 2019

Acquired resistance to EGFR tyrosine kinase inhibitors is mediated by the reactivation of STC2/JUN/AXL signaling in lung cancer.

Int J Cancer 2019 09 25;145(6):1609-1624. Epub 2019 Jun 25.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1002/ijc.32487DOI Listing
September 2019

Improved prognosis with induction chemotherapy in pathological complete responders after trimodality treatment for esophageal squamous cell carcinoma: Hypothesis generating for adjuvant treatment.

Eur J Surg Oncol 2019 Aug 19;45(8):1498-1504. Epub 2019 Mar 19.

Division of Radiation Oncology, National Taiwan University Hospital, Taiwan; Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ejso.2019.03.020DOI Listing
August 2019

Mixed squamous cell and glandular papilloma of the lung: A case report of a novel mutation in the BRAF gene and coexistent HPV infection, possible relationship to ciliated muconodular papillary tumor.

Pathol Int 2019 Feb 21;69(2):104-109. Epub 2019 Jan 21.

Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7, Chung-Shan South Road, Taipei 10002, Taiwan.

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http://dx.doi.org/10.1111/pin.12747DOI Listing
February 2019

Prevalence of current oral HPV infection among 100 betel nut chewers or cigarette smokers in Northern Taiwan.

J Formos Med Assoc 2019 Jan 7;118(1 Pt 1):203-208. Epub 2018 Apr 7.

Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2018.03.013DOI Listing
January 2019

The Differences in Clinicopathologic and Prognostic Characteristics Between Surgically Resected Peripheral and Central Lung Squamous Cell Carcinoma.

Ann Surg Oncol 2019 Jan 19;26(1):217-229. Epub 2018 Nov 19.

Graduate Institute of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1245/s10434-018-6993-5DOI Listing
January 2019

IGFBP7 Drives Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition in Lung Cancer.

Cancers (Basel) 2019 Jan 2;11(1). Epub 2019 Jan 2.

Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei 10002, Taiwan.

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http://www.mdpi.com/2072-6694/11/1/36
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http://dx.doi.org/10.3390/cancers11010036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356910PMC
January 2019

Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis.

J Exp Clin Cancer Res 2019 Jan 6;38(1). Epub 2019 Jan 6.

Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, No. 2, Syu-Jhou Rd, Taipei, 100, Taiwan.

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https://jeccr.biomedcentral.com/articles/10.1186/s13046-018-
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http://dx.doi.org/10.1186/s13046-018-0996-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322271PMC
January 2019

Prognostic significance of tumor-infiltrating lymphocytes in patients with operable tongue cancer.

Radiat Oncol 2018 Aug 28;13(1):157. Epub 2018 Aug 28.

Cancer Research Center, National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1186/s13014-018-1099-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114480PMC
August 2018

M1 macrophages decrease in the deciduae from normal pregnancies but not from spontaneous abortions or unexplained recurrent spontaneous abortions.

J Formos Med Assoc 2018 Mar 29;117(3):204-211. Epub 2017 Apr 29.

Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2017.03.011DOI Listing
March 2018

Outcomes in patients with non-small-cell lung cancer and acquired Thr790Met mutation treated with osimertinib: a genomic study.

Lancet Respir Med 2018 02 14;6(2):107-116. Epub 2017 Dec 14.

Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132600173048
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http://dx.doi.org/10.1016/S2213-2600(17)30480-0DOI Listing
February 2018

Globo H expression is associated with driver mutations and PD-L1 expressions in stage I non-small cell lung cancer.

Cancer Biomark 2017 Dec;21(1):211-220

Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 10002, Taiwan.

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http://dx.doi.org/10.3233/CBM-170660DOI Listing
December 2017

Clinicopathological features and prognosis of patients with de novo versus nevus-associated melanoma in Taiwan.

PLoS One 2017 4;12(5):e0177126. Epub 2017 May 4.

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177126PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417671PMC
September 2017

Astrocyte-elevated gene-1 confers resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase expression.

Oncotarget 2017 Sep 28;8(37):61901-61916. Epub 2017 Jun 28.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.18632/oncotarget.18717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617473PMC
September 2017

Upregulation of microRNA-137 expression by Slug promotes tumor invasion and metastasis of non-small cell lung cancer cells through suppression of TFAP2C.

Cancer Lett 2017 08 10;402:190-202. Epub 2017 Jun 10.

Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei 10002, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.06.002DOI Listing
August 2017

Single-Tube Reaction Using Perfluorocarbons: A Prerequisite Step Leading to the Whole-Slide In Situ Technique on Histopathological Slides.

PLoS One 2016 23;11(6):e0158018. Epub 2016 Jun 23.

Department and Graduate Institute of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158018PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919083PMC
July 2017

The Pretreatment Neutrophil-to-Lymphocyte Ratio is a Prognostic Determinant of T3-4 Hypopharyngeal Squamous Cell Carcinoma.

Ann Surg Oncol 2017 Jul 21;24(7):1980-1988. Epub 2017 Apr 21.

Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1245/s10434-017-5865-8DOI Listing
July 2017

A clinicopathological analysis of 153 acral melanomas and the relevance of mechanical stress.

Sci Rep 2017 07 17;7(1):5564. Epub 2017 Jul 17.

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, 7 Chun-Shan South Road, Taipei, 10002, Taiwan.

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http://dx.doi.org/10.1038/s41598-017-05809-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514126PMC
July 2017

Lung adenocarcinoma patients of young age have lower mutation rate and poorer efficacy of EGFR tyrosine kinase inhibitors.

ERJ Open Res 2017 Jul 12;3(3). Epub 2017 Jul 12.

Dept of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taiwan.

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http://dx.doi.org/10.1183/23120541.00092-2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507146PMC
July 2017

Lymph Node Ratio Predicts Recurrence and Survival for Patients with Resectable Stage 4 Hypopharyngeal Cancer.

Ann Surg Oncol 2017 Jun 27;24(6):1707-1713. Epub 2017 Jan 27.

Department and Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei, 100, Taiwan.

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http://dx.doi.org/10.1245/s10434-017-5770-1DOI Listing
June 2017

Histologic Transformation in a Patient with Lung Cancer Treated with Chemotherapy and Pembrolizumab.

J Thorac Oncol 2017 06;12(6):e75-e76

Department of Pathology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Republic of China; Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei, Republic of China.

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http://dx.doi.org/10.1016/j.jtho.2017.02.006DOI Listing
June 2017

Evaluation of geranylgeranylacetone against cisplatin-induced ototoxicity by auditory brainstem response, heat shock proteins and oxidative levels in guinea pigs.

Neurotoxicol Teratol 2017 05 24;61:29-35. Epub 2017 Mar 24.

Department of Otolaryngology, Far Eastern Memorial Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ntt.2017.03.004DOI Listing
May 2017

Reevaluation of MAML2 fusion-negative mucoepidermoid carcinoma: a subgroup being actually hyalinizing clear cell carcinoma of the salivary gland with EWSR1 translocation.

Hum Pathol 2017 03 18;61:9-18. Epub 2016 Oct 18.

Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 10002, Taiwan; Graduate Institute of Pathology, College of Medicine, National Taiwan University, Taipei 10002, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00468177163024
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http://dx.doi.org/10.1016/j.humpath.2016.06.029DOI Listing
March 2017

High PD-L1 expression is associated with stage IV disease and poorer overall survival in 186 cases of small cell lung cancers.

Oncotarget 2017 Mar;8(11):18021-18030

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 10002, Taiwan.

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http://dx.doi.org/10.18632/oncotarget.14935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392304PMC
March 2017

SOX10-positive salivary gland tumors: a growing list, including mammary analogue secretory carcinoma of the salivary gland, sialoblastoma, low-grade salivary duct carcinoma, basal cell adenoma/adenocarcinoma, and a subgroup of mucoepidermoid carcinoma.

Hum Pathol 2016 10 17;56:134-42. Epub 2016 Jun 17.

Department of Pathology, National Taiwan University Hospital and National Taiwan, University College of Medicine, Taipei, Taiwan 100; Graduate Institute of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan 100. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2016.05.021DOI Listing
October 2016

The Role of PIK3CA Mutations among Lung Adenocarcinoma Patients with Primary and Acquired Resistance to EGFR Tyrosine Kinase Inhibition.

Sci Rep 2016 10 13;6:35249. Epub 2016 Oct 13.

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1038/srep35249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062358PMC
October 2016

The Prognostic Significance of pSTAT1 and CD163 Expressions in Surgically Resected Stage 1 Pulmonary Squamous Cell Carcinomas.

Ann Surg Oncol 2016 09 5;23(9):3071-81. Epub 2016 May 5.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1245/s10434-016-5244-xDOI Listing
September 2016

Insulin-Like Growth Factor II mRNA-Binding Protein 3 Expression Correlates with Poor Prognosis in Acral Lentiginous Melanoma.

PLoS One 2016 21;11(1):e0147431. Epub 2016 Jan 21.

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147431PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721868PMC
August 2016

Assessment of D-methionine protecting cisplatin-induced otolith toxicity by vestibular-evoked myogenic potential tests, ATPase activities and oxidative state in guinea pigs.

Neurotoxicol Teratol 2015 Sep-Oct;51:12-20. Epub 2015 Jul 26.

Department of Otolaryngology, Far Eastern Memorial Hospital, Taipei, Taiwan; Oriental Institute of Technology, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ntt.2015.07.004DOI Listing
July 2016

Efficacy of Pemetrexed-Based Chemotherapy in Patients with ROS1 Fusion-Positive Lung Adenocarcinoma Compared with in Patients Harboring Other Driver Mutations in East Asian Populations.

J Thorac Oncol 2016 07 16;11(7):1140-52. Epub 2016 Apr 16.

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei 10002, Republic of China; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2016.03.022DOI Listing
July 2016

High co-expression of PD-L1 and HIF-1α correlates with tumour necrosis in pulmonary pleomorphic carcinoma.

Eur J Cancer 2016 06 22;60:125-35. Epub 2016 Apr 22.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7, Chung-Shan S. Rd., Taipei 10002, Taiwan; Graduate Institute of Pathology, National Taiwan University College of Medicine, No. 7, Chung-Shan S. Rd., Taipei 10002, Taiwan; National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan.

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http://dx.doi.org/10.1016/j.ejca.2016.03.012DOI Listing
June 2016

BRAF mutation may have different prognostic implications in early- and late-stage colorectal cancer.

Med Oncol 2016 May 31;33(5):39. Epub 2016 Mar 31.

Department of Oncology, National Taiwan University Hospital, No 7, Chung-Shan South Rd, Taipei, 10002, Taiwan.

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http://dx.doi.org/10.1007/s12032-016-0756-6DOI Listing
May 2016

Regular screening of esophageal cancer for 248 newly diagnosed hypopharyngeal squamous cell carcinoma by unsedated transnasal esophagogastroduodenoscopy.

Oral Oncol 2016 Apr 1;55:55-60. Epub 2016 Feb 1.

Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan; Graduate Institute of Pathology, National Taiwan University, College of Medicine, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2016.01.008DOI Listing
April 2016

Programmed cell death-ligand 1 expression is associated with a favourable immune microenvironment and better overall survival in stage I pulmonary squamous cell carcinoma.

Eur J Cancer 2016 Apr 21;57:91-103. Epub 2016 Feb 21.

Department of Internal Medicine, Taiwan, ROC; Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei 10002, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.ejca.2015.12.033DOI Listing
April 2016

Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon.

Nat Commun 2014 ;5:3344

1] Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 100, Taiwan [2] NTU Center for Genomic Medicine, National Taiwan University College of Medicine, Taipei 100, Taiwan [3] Department of Laboratory Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.

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http://dx.doi.org/10.1038/ncomms4344DOI Listing
November 2015

Associations among pretreatment tumor necrosis and the expression of HIF-1α and PD-L1 in advanced oral squamous cell carcinoma and the prognostic impact thereof.

Oral Oncol 2015 Nov 11;51(11):1004-1010. Epub 2015 Sep 11.

Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 10002, Taiwan; Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei 10002, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2015.08.011DOI Listing
November 2015

Intrathoracic thyroid solitary fibrous tumor presenting with respiratory failure.

Ann Thorac Cardiovasc Surg 2014 28;20 Suppl:427-9. Epub 2013 Feb 28.

Department of Surgery, National Taiwan University Hospital Yun-Lin Branch, Yunlin, Taiwan.

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http://dx.doi.org/10.5761/atcs.cr.12.02068DOI Listing
October 2015

Intussusception caused by intestinal metastasis from lung pleomorphic carcinoma.

Ann Thorac Cardiovasc Surg 2014 31;20 Suppl:635-8. Epub 2013 Jul 31.

Department of Surgery, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan; Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.5761/atcs.cr.13-00099DOI Listing
October 2015

Papillary-cystic pattern is characteristic in mammary analogue secretory carcinomas but is rarely observed in acinic cell carcinomas of the salivary gland.

Virchows Arch 2015 Aug 15;467(2):145-53. Epub 2015 May 15.

Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, No 7, Chung-Shan South Road, 100, Taipei, Taiwan.

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http://dx.doi.org/10.1007/s00428-015-1786-8DOI Listing
August 2015

Mixed mucoepidermoid carcinoma and adenocarcinoma of the lung: Two cases with unusual histologic features.

Lung Cancer 2015 Jul 30;89(1):80-3. Epub 2015 Apr 30.

Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2015.04.010DOI Listing
July 2015

Cetuximab Might Be Detrimental to Metastatic Colorectal Cancer Patients with KRAS Codon 12 Mutations.

Anticancer Res 2015 Jul;35(7):4207-14

Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan, R.O.C. Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan, R.O.C. Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, R.O.C.

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July 2015

PD-L1 is highly expressed in lung lymphoepithelioma-like carcinoma: A potential rationale for immunotherapy.

Lung Cancer 2015 Jun 21;88(3):254-9. Epub 2015 Mar 21.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei, Taiwan; National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.lungcan.2015.03.017DOI Listing
June 2015

Positive immunostaining of thyroid transcription factor-1 in primary nasopharyngeal papillary adenocarcinoma.

J Formos Med Assoc 2015 May 27;114(5):473-4. Epub 2013 Jun 27.

Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan; Department of Otolaryngology, Buddhist Tzu Chi General Hospital, Taichung Branch, Taichung, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2013.04.012DOI Listing
May 2015

Significance of nuclear p-mTOR expression in advanced oral squamous cell carcinoma with extracapsular extension of lymph node metastases.

Oral Oncol 2015 May 11;51(5):493-9. Epub 2015 Mar 11.

Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 10002, Taiwan; Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei 10002, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2015.02.093DOI Listing
May 2015

Circulating mRNA Profiling in Esophageal Squamous Cell Carcinoma Identifies FAM84B As A Biomarker In Predicting Pathological Response to Neoadjuvant Chemoradiation.

Sci Rep 2015 May 18;5:10291. Epub 2015 May 18.

1] Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan [2] Bioinformatics and Biostatistics Core, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan.

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http://www.nature.com/articles/srep10291
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http://dx.doi.org/10.1038/srep10291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434848PMC
May 2015

Identification of a novel FN1-FGFR1 genetic fusion as a frequent event in phosphaturic mesenchymal tumour.

J Pathol 2015 Mar 7;235(4):539-45. Epub 2015 Jan 7.

Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1002/path.4465DOI Listing
March 2015

DUSP1 expression induced by HDAC1 inhibition mediates gefitinib sensitivity in non-small cell lung cancers.

Clin Cancer Res 2015 Jan;21(2):428-38

Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-14-1150DOI Listing
January 2015

Oxaliplatin-based chemotherapy is more beneficial in KRAS mutant than in KRAS wild-type metastatic colorectal cancer patients.

PLoS One 2014 4;9(2):e86789. Epub 2014 Feb 4.

Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan ; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan ; Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086789PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913571PMC
December 2014

Crystal amphetamine smoking-induced acute eosinophilic pneumonia and diffuse alveolar damage: a case report and literature review.

Chin J Physiol 2014 Oct;57(5):295-8

Division of Chest Medicine, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 11101, Taiwan, Republic of China.

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http://dx.doi.org/10.4077/CJP.2014.BAC201DOI Listing
October 2014

Clinicopathology and genetic profile of synchronous multiple small adenocarcinomas: implication for surgical treatment of an uncommon lung malignancy.

Ann Surg Oncol 2014 Aug 19;21(8):2555-62. Epub 2014 Mar 19.

Department of Surgery, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.

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http://dx.doi.org/10.1245/s10434-014-3642-5DOI Listing
August 2014

Clinicopathologic characteristics and prognostic significance of EGFR and p53 mutations in surgically resected lung adenocarcinomas ≤2 cm in maximal dimension.

J Surg Oncol 2014 Aug 30;110(2):99-106. Epub 2014 Apr 30.

Department of Surgery, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu City, Taiwan; Graduate Institute of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1002/jso.23628DOI Listing
August 2014

Clinical and the prognostic characteristics of lung adenocarcinoma patients with ROS1 fusion in comparison with other driver mutations in East Asian populations.

J Thorac Oncol 2014 Aug;9(8):1171-9

*Department of Internal Medicine, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin; †Department of Pathology; ‡Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei; §Department of Molecular Biotechnology, Da-Yeh University, Chang-Hua; ‖Department of Oncology, National Taiwan University Hospital; and ¶Graduate Institute of Oncology Cancer Research Centre, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1097/JTO.0000000000000232DOI Listing
August 2014

Multidriver mutation analysis in pulmonary mucinous adenocarcinoma in Taiwan: identification of a rare CD74-NRG1 translocation case.

Med Oncol 2014 Jul 10;31(7):34. Epub 2014 Jun 10.

Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, 220, Taiwan.

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http://dx.doi.org/10.1007/s12032-014-0034-4DOI Listing
July 2014

New aspects of the clinicopathology and genetic profile of metachronous multiple lung cancers.

Ann Surg 2014 May;259(5):1018-24

Departments of *Pathology †Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan ‡Department of Surgery, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu City, Taiwan.

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http://dx.doi.org/10.1097/SLA.0000000000000385DOI Listing
May 2014

Programmed cell death-ligand 1 expression in surgically resected stage I pulmonary adenocarcinoma and its correlation with driver mutations and clinical outcomes.

Eur J Cancer 2014 May 15;50(7):1361-9. Epub 2014 Feb 15.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, 7 Chung-Shan South Road, Taipei 10002, Taiwan.

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http://dx.doi.org/10.1016/j.ejca.2014.01.018DOI Listing
May 2014

Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling.

Nat Commun 2014 Mar 25;5:3472. Epub 2014 Mar 25.

1] Graduate Institute of Oncology, National Taiwan University Medical College, Taipei 10051, Taiwan [2] Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University Medical College, Taipei 10051, Taiwan [3] Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.

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http://dx.doi.org/10.1038/ncomms4472DOI Listing
March 2014

Constructive remarks concerning visceral pleural surface invasion in non-small cell lung cancer patients.

Ann Thorac Surg 2014 Feb;97(2):735

Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7, Chung-Shan S Rd, Taipei 10002, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.athoracsur.2013.07.111DOI Listing
February 2014

MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1.

Nat Commun 2013 ;4:1877

Graduate Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei 10043, Taiwan.

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http://dx.doi.org/10.1038/ncomms2876DOI Listing
December 2013

Expansile kaposiform hemangioendothelioma deformed thoracic cage in an adult.

Ann Thorac Surg 2013 Nov;96(5):1854-7

Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.athoracsur.2013.02.059DOI Listing
November 2013

Unusual presentation of lymphoepithelioma-like carcinoma of lung as a thin-walled cavity.

Ann Thorac Surg 2013 Nov;96(5):1857-9

Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.athoracsur.2013.03.021DOI Listing
November 2013

Human pulmonary dirofilariasis coexisting with intercostal neurilemmoma: a case report and literature review.

J Formos Med Assoc 2013 Oct 27;112(10):644-7. Epub 2013 Sep 27.

Division of Thoracic Surgery, Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.jfma.2012.07.016DOI Listing
October 2013

The impact of perineural invasion and/or lymphovascular invasion on the survival of early-stage oral squamous cell carcinoma patients.

Ann Surg Oncol 2013 Jul 30;20(7):2388-95. Epub 2013 Jan 30.

Department of Otolaryngology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1245/s10434-013-2870-4DOI Listing
July 2013

Tid1-L inhibits EGFR signaling in lung adenocarcinoma by enhancing EGFR Ubiquitinylation and degradation.

Cancer Res 2013 Jul 22;73(13):4009-19. Epub 2013 May 22.

Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Taoyuan, Taiwan.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-4066DOI Listing
July 2013

Oxaliplatin-based Chemotherapy Might Provide Longer Progression-Free Survival in KRAS Mutant Metastatic Colorectal Cancer.

Transl Oncol 2013 Jun 1;6(3):363-9. Epub 2013 Jun 1.

Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan ; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660806PMC
http://dx.doi.org/10.1593/tlo.13166DOI Listing
June 2013

The clinical predictive factors for subsequent distant metastasis in patients with locoregionally advanced oral squamous cell carcinoma.

Oral Oncol 2013 Apr 9;49(4):367-73. Epub 2012 Nov 9.

Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.oraloncology.2012.10.006DOI Listing
April 2013

The significance of visceral pleural surface invasion in 321 cases of non-small cell lung cancers with pleural retraction.

Ann Surg Oncol 2012 Sep 11;19(9):3057-64. Epub 2012 Apr 11.

Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1245/s10434-012-2354-yDOI Listing
September 2012

The determining risk factors for treatment outcomes in patients with squamous cell carcinoma of the hard palate.

Ann Surg Oncol 2012 Jun 20;19(6):2003-10. Epub 2012 Jan 20.

Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1245/s10434-011-2214-1DOI Listing
June 2012

TROP2 is epigenetically inactivated and modulates IGF-1R signalling in lung adenocarcinoma.

EMBO Mol Med 2012 Jun 15;4(6):472-85. Epub 2012 Mar 15.

Department of Respiratory Therapy, Fu-Jen Catholic University, New Taipei, Taiwan.

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http://dx.doi.org/10.1002/emmm.201200222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443948PMC
June 2012

Effusion immunocytochemistry as an alternative approach for the selection of first-line targeted therapy in advanced lung adenocarcinoma.

J Thorac Oncol 2012 Jun;7(6):993-1000

Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1097/JTO.0b013e31824cc46bDOI Listing
June 2012

Pulmonary metastatic giant cell tumors presenting as totally hyalinized and ossified nodules.

Ann Thorac Surg 2012 Jun;93(6):2044-7

Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.athoracsur.2011.10.055DOI Listing
June 2012

Common genetic mutations in the start codon of the SDH subunit D gene among Chinese families with familial head and neck paragangliomas.

Oral Oncol 2012 Feb 25;48(2):125-9. Epub 2011 Sep 25.

Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.oraloncology.2011.08.025DOI Listing
February 2012

EML4-ALK translocation predicts better outcome in lung adenocarcinoma patients with wild-type EGFR.

J Thorac Oncol 2012 Jan;7(1):98-104

Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan.

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http://dx.doi.org/10.1097/JTO.0b013e3182370e30DOI Listing
January 2012

Thymidylate synthase and dihydrofolate reductase expression in non-small cell lung carcinoma: the association with treatment efficacy of pemetrexed.

Lung Cancer 2011 Oct 1;74(1):132-8. Epub 2011 Mar 1.

Division of Pulmonary Medicine, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, No. 7, Chung-Shan South Road, Taipei 100, Taiwan.

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http://dx.doi.org/10.1016/j.lungcan.2011.01.024DOI Listing
October 2011

EGFR and p53 status of pulmonary pleomorphic carcinoma: implications for EGFR tyrosine kinase inhibitors therapy of an aggressive lung malignancy.

Ann Surg Oncol 2011 Oct 16;18(10):2952-60. Epub 2011 Mar 16.

Department of Pathology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1245/s10434-011-1621-7DOI Listing
October 2011

Tumor satellite in predicting occult nodal metastasis of tongue cancer.

Otolaryngol Head Neck Surg 2011 Oct 13;145(4):599-605. Epub 2011 Jun 13.

Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1177/0194599811411635DOI Listing
October 2011

Significance of tumor satellite variables in reflecting the epithelial-mesenchymal transition of tongue cancer.

Oral Oncol 2011 Aug 12;47(8):720-4. Epub 2011 Jun 12.

Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

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http://linkinghub.elsevier.com/retrieve/pii/S136883751100133
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http://dx.doi.org/10.1016/j.oraloncology.2011.04.006DOI Listing
August 2011