Yigal M Pinto

Yigal M Pinto

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Yigal M Pinto

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Diagnostic tools for early detection of cardiac dysfunction in childhood cancer survivors: Methodological aspects of the Dutch late effects after childhood cancer (LATER) cardiology study.

Authors:
Jan M Leerink E Lieke A M Feijen Helena J H van der Pal Wouter E M Kok Annelies M C Mavinkurve-Groothuis Livia Kapusta Yigal M Pinto Angela H E M Maas Louise Bellersen Arco J Teske Cécile M Ronckers Marloes Louwerens Elvira C van Dalen Eline van Dulmen-den Broeder Lilian Batenburg Margriet van der Heiden-van der Loo Marry M van den Heuvel-Eibrink Flora E van Leeuwen Andrica C H de Vries Gert Weijers Chris L de Korte Jacqueline J Loonen Sebastian J C M M Neggers A B Birgitta Versluys Wim J E Tissing Leontien C M Kremer

Am Heart J 2019 Nov 9;219:89-98. Epub 2019 Nov 9.

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands; Amsterdam UMC, University of Amsterdam, Department of Pediatric Oncology, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ahj.2019.10.010DOI Listing
November 2019

Risk Prediction in Transition: MAGGIC Score Performance at Discharge and Incremental Utility of Natriuretic Peptides.

Authors:
Alexander Michaels Lindsey Aurora Edward Peterson Bin Liu Yigal M Pinto Hani N Sabbah Keoki Williams David E Lanfear

J Card Fail 2019 Nov 18. Epub 2019 Nov 18.

Heart and Vascular Institute, Henry Ford Hospital, Detroit, Michigan; Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan; Center for Individualized and Genomic Medicine Research, Henry Ford Hospital, Detroit, Michigan. Electronic address:

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http://dx.doi.org/10.1016/j.cardfail.2019.11.016DOI Listing
November 2019

Multimodality imaging in the diagnosis, risk stratification, and management of patients with dilated cardiomyopathies: an expert consensus document from the European Association of Cardiovascular Imaging.

Authors:
Erwan Donal Victoria Delgado Chiara Bucciarelli-Ducci Elena Galli Kristina H Haugaa Philippe Charron Jens-Uwe Voigt Nuno Cardim P G Masci Maurizio Galderisi Oliver Gaemperli Alessia Gimelli Yigal M Pinto Patrizio Lancellotti Gilbert Habib Perry Elliott Thor Edvardsen Bernard Cosyns Bogdan A Popescu

Eur Heart J Cardiovasc Imaging 2019 Oct;20(10):1075-1093

Department of Cardiology, University of Medicine and Pharmacy "Carol Davila"- Euroecolab, Emergency Institute of Cardiovascular Diseases "Prof. Dr. C. C. Iliescu", Sos. Fundeni 258, Sector 2, Bucharest, Romania.

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http://dx.doi.org/10.1093/ehjci/jez178DOI Listing
October 2019

Circular RNAs open a new chapter in cardiovascular biology.

Authors:
Simona Aufiero Yolan J Reckman Yigal M Pinto Esther E Creemers

Nat Rev Cardiol 2019 Aug;16(8):503-514

Department of Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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http://www.nature.com/articles/s41569-019-0185-2
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http://dx.doi.org/10.1038/s41569-019-0185-2DOI Listing
August 2019

Prognosis and NT-proBNP in heart failure patients with preserved versus reduced ejection fraction.

Authors:
Khibar Salah Susan Stienen Yigal M Pinto Luc W Eurlings Marco Metra Antoni Bayes-Genis Valerio Verdiani Jan G P Tijssen Wouter E Kok

Heart 2019 Aug 8;105(15):1182-1189. Epub 2019 Apr 8.

Heart Centre, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amasterdam, The Netherlands.

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http://dx.doi.org/10.1136/heartjnl-2018-314173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662953PMC
August 2019

External Validation of the ELAN-HF Score, Predicting 6-Month All-Cause Mortality in Patients Hospitalized for Acute Decompensated Heart Failure.

Authors:
Khibar Salah Susan Stienen Andreas H M Moons Adrianus L M Bakx Petra E van Pol R A Mikael Kortz João Pedro Ferreira Irene Marques Jutta M Schroeder-Tanka Jan T Keijer Antoni Bayes-Genis Yigal M Pinto Jan G Tijssen Wouter E Kok

J Am Heart Assoc 2019 Jul 12;8(14):e010309. Epub 2019 Jul 12.

1 Heart Center Department of Clinical and Experimental Cardiology Amsterdam Cardiovascular Sciences Amsterdam University Medical Center University of Amsterdam Amsterdam the Netherlands.

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http://dx.doi.org/10.1161/JAHA.118.010309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662127PMC
July 2019

Heritability in genetic heart disease: the role of genetic background.

Authors:
Joeri A Jansweijer Karin Y van Spaendonck-Zwarts Michael W T Tanck J Peter van Tintelen Imke Christiaans Jasper van der Smagt Alexa Vermeer J Martijn Bos Arthur J Moss Heikki Swan Sylvia Priori Annika Rydberg Jacob Tfelt-Hansen Michael Ackerman Iacopo Olivotto Philippe Charron Juan R Gimeno Maarten van den Berg Arthur Wilde Yigal M Pinto

Open Heart 2019 28;6(1):e000929. Epub 2019 May 28.

Heart Center, Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.

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http://dx.doi.org/10.1136/openhrt-2018-000929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546190PMC
May 2019

Therapeutic Delivery of miR-148a Suppresses Ventricular Dilation in Heart Failure.

Authors:
Andrea Raso Ellen Dirkx Leonne E Philippen Amaya Fernandez-Celis Federica De Majo Vasco Sampaio-Pinto Marida Sansonetti Rio Juni Hamid El Azzouzi Martina Calore Nicole Bitsch Servé Olieslagers Martinus I F J Oerlemans Manon M Huibers Roel A de Weger Yolan J Reckman Yigal M Pinto Lorena Zentilin Serena Zacchigna Mauro Giacca Paula A da Costa Martins Natalia López-Andrés Leon J De Windt

Mol Ther 2019 03 17;27(3):584-599. Epub 2018 Nov 17.

Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403487PMC
March 2019

Relevance of Titin Missense and Non-Frameshifting Insertions/Deletions Variants in Dilated Cardiomyopathy.

Authors:
Oyediran Akinrinade Tiina Heliö Ronald H Lekanne Deprez Jan D H Jongbloed Ludolf G Boven Maarten P van den Berg Yigal M Pinto Tero-Pekka Alastalo Samuel Myllykangas Karin van Spaendonck-Zwarts J Peter van Tintelen Paul A van der Zwaag Juha Koskenvuo

Sci Rep 2019 Mar 11;9(1):4093. Epub 2019 Mar 11.

Blueprint Genetics, Helsinki, Finland.

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http://dx.doi.org/10.1038/s41598-019-39911-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412046PMC
March 2019

Biomarkers to diagnose ventricular dysfunction in childhood cancer survivors: a systematic review.

Authors:
Jan M Leerink Simone J Verkleij Elizabeth A M Feijen Annelies M C Mavinkurve-Groothuis Milanthy S Pourier Kaisa Ylänen Wim J E Tissing Marloes Louwerens Marry M van den Heuvel Eline van Dulmen-den Broeder Andrica C H de Vries Cecile M Ronckers Heleen J H van der Pal Livia Kapusta Jacqueline Loonen Louise Bellersen Yigal M Pinto Leontien C M Kremer Wouter E M Kok

Heart 2019 02 29;105(3):210-216. Epub 2018 Aug 29.

Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Heart Center, Amsterdam, The Netherlands.

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http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2018-313634
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http://dx.doi.org/10.1136/heartjnl-2018-313634DOI Listing
February 2019

Formins Emerge as a Cause of Hypertrophic Cardiomyopathy: New Genes for Thick Hearts.

Authors:
Yigal M Pinto Yolan J Reckman

J Am Coll Cardiol 2018 11;72(20):2468-2470

Department of Experimental Cardiology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.jacc.2018.09.026DOI Listing
November 2018

The clinical outcome of LMNA missense mutations can be associated with the amount of mutated protein in the nuclear envelope.

Authors:
Rasha A Al-Saaidi Torsten B Rasmussen Rune I D Birkler Johan Palmfeldt Abdelaziz Beqqali Yigal M Pinto Peter H Nissen Ulrik Baandrup Henning Mølgaard Thomas M Hey Hans Eiskjaer Peter Bross Jens Mogensen

Eur J Heart Fail 2018 10 26;20(10):1404-1412. Epub 2018 Jun 26.

Department of Cardiology, Odense University Hospital, Odense, Denmark.

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http://dx.doi.org/10.1002/ejhf.1241DOI Listing
October 2018

The MEF2 transcriptional target DMPK induces loss of sarcomere structure and cardiomyopathy.

Authors:
Amin Damanafshan Ies Elzenaar Benoit Samson-Couterie Ingeborg van der Made Meriem Bourajjaj Maarten M van den Hoogenhof Henk A van Veen Daisy I Picavet Abdelaziz Beqqali Elisabeth Ehler Leon J De Windt Yigal M Pinto Ralph J van Oort

Cardiovasc Res 2018 09;114(11):1474-1486

Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/cvr/cvy091DOI Listing
September 2018

RBM20 Mutations Induce an Arrhythmogenic Dilated Cardiomyopathy Related to Disturbed Calcium Handling.

Authors:
Maarten M G van den Hoogenhof Abdelaziz Beqqali Ahmad S Amin Ingeborg van der Made Simona Aufiero Mohsin A F Khan Cees A Schumacher Joeri A Jansweijer Karin Y van Spaendonck-Zwarts Carol Ann Remme Johannes Backs Arie O Verkerk Antonius Baartscheer Yigal M Pinto Esther E Creemers

Circulation 2018 09;138(13):1330-1342

Department of Experimental Cardiology (M.M.G.v.d.H., A.B., A.S.A., I.v.d.M., S.A., M.A.F.K., C.A.S., J.A.J., C.A.R., A.o.V., A.B., Y.M.P., E.E.C.), Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.031947DOI Listing
September 2018

AAV9-mediated Rbm24 overexpression induces fibrosis in the mouse heart.

Authors:
Maarten M G van den Hoogenhof Ingeborg van der Made Nina E de Groot Amin Damanafshan Shirley C M van Amersfoorth Lorena Zentilin Mauro Giacca Yigal M Pinto Esther E Creemers

Sci Rep 2018 08 3;8(1):11696. Epub 2018 Aug 3.

Department of Experimental Cardiology, Academic Medical Center (AMC), Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41598-018-29552-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076270PMC
August 2018

Additional Genetic Variants in Inherited Dilated Cardiomyopathy: Just Another Brick in the Wall?

Authors:
J Peter van Tintelen Yigal M Pinto

Circ Genom Precis Med 2018 07;11(7):e002249

Department of Cardiology (Y.M.P.).

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http://dx.doi.org/10.1161/CIRCGEN.118.002249DOI Listing
July 2018

Cardiac circRNAs arise mainly from constitutive exons rather than alternatively spliced exons.

Authors:
Simona Aufiero Maarten M G van den Hoogenhof Yolan J Reckman Abdelaziz Beqqali Ingeborg van der Made Jolanda Kluin Mohsin A F Khan Yigal M Pinto Esther E Creemers

RNA 2018 06 22;24(6):815-827. Epub 2018 Mar 22.

Department of Experimental Cardiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam 1105AZ, The Netherlands.

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http://dx.doi.org/10.1261/rna.064394.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959250PMC
June 2018

Race and Beta-Blocker Survival Benefit in Patients With Heart Failure: An Investigation of Self-Reported Race and Proportion of African Genetic Ancestry.

Authors:
Jasmine A Luzum Edward Peterson Jia Li Ruicong She Hongsheng Gui Bin Liu John A Spertus Yigal M Pinto L Keoki Williams Hani N Sabbah David E Lanfear

J Am Heart Assoc 2018 05 8;7(10). Epub 2018 May 8.

Center for Health Policy and Health Services Research, Henry Ford Health System, Detroit, MI

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https://www.ahajournals.org/doi/10.1161/JAHA.117.007956
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http://dx.doi.org/10.1161/JAHA.117.007956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015313PMC
May 2018

The first titin (c.59926 + 1G > A) founder mutation associated with dilated cardiomyopathy.

Authors:
Edgar T Hoorntje Karin Y van Spaendonck-Zwarts Wouter P Te Rijdt Ludolf Boven Aryan Vink Jasper J van der Smagt Folkert W Asselbergs Jan van Wijngaarden Eric A Hennekam Yigal M Pinto Ronald H Lekanne Deprez Daniela Q C M Barge-Schaapveld Marianne Bootsma Jakub Regieli Yvonne M Hoedemaekers Jan D H Jongbloed Maarten P van den Berg J Peter van Tintelen

Eur J Heart Fail 2018 04 23;20(4):803-806. Epub 2017 Oct 23.

Netherlands Heart Institute, Utrecht, the Netherlands.

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http://dx.doi.org/10.1002/ejhf.1030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993291PMC
April 2018

NT-proBNP (N-Terminal pro-B-Type Natriuretic Peptide)-Guided Therapy in Acute Decompensated Heart Failure: PRIMA II Randomized Controlled Trial (Can NT-ProBNP-Guided Therapy During Hospital Admission for Acute Decompensated Heart Failure Reduce Mortality and Readmissions?).

Authors:
Susan Stienen Khibar Salah Arno H Moons Adrianus L Bakx Petra van Pol R A Mikael Kortz João Pedro Ferreira Irene Marques Jutta M Schroeder-Tanka Jan T Keijer Antoni Bayés-Genis Jan G P Tijssen Yigal M Pinto Wouter E Kok

Circulation 2018 04 14;137(16):1671-1683. Epub 2017 Dec 14.

Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands (S.S., K.S., J.G.P.T., Y.M.P., W.E.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.029882DOI Listing
April 2018

Serially measured circulating microRNAs and adverse clinical outcomes in patients with acute heart failure.

Authors:
Nick van Boven Isabella Kardys Laura C van Vark K Martijn Akkerhuis Maurice W J de Ronde Mohsin A F Khan Daphne Merkus Zhen Liu Adriaan A Voors Folkert W Asselbergs Ewout-Jan van den Bos Eric Boersma Hans Hillege Dirk J Duncker Yigal M Pinto Douwe Postmus

Eur J Heart Fail 2018 01 25;20(1):89-96. Epub 2017 Sep 25.

Department of Epidemiology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1002/ejhf.950DOI Listing
January 2018

Prognostic value of circulating microRNAs on heart failure-related morbidity and mortality in two large diverse cohorts of general heart failure patients.

Authors:
Antoni Bayés-Genis David E Lanfear Maurice W J de Ronde Josep Lupón Joost J Leenders Zhen Liu Nicolaas P A Zuithoff Marinus J C Eijkemans Elisabet Zamora Marta De Antonio Aeilko H Zwinderman Sara-Joan Pinto-Sietsma Yigal M Pinto

Eur J Heart Fail 2018 01 26;20(1):67-75. Epub 2017 Sep 26.

ACS Biomarker BV, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/ejhf.984DOI Listing
January 2018

Myofilament Remodeling and Function Is More Impaired in Peripartum Cardiomyopathy Compared with Dilated Cardiomyopathy and Ischemic Heart Disease.

Authors:
Ilse A E Bollen Elisabeth Ehler Karin Fleischanderl Floor Bouwman Lanette Kempers Melanie Ricke-Hoch Denise Hilfiker-Kleiner Cristobal G Dos Remedios Martina Krüger Aryan Vink Folkert W Asselbergs Karin Y van Spaendonck-Zwarts Yigal M Pinto Diederik W D Kuster Jolanda van der Velden

Am J Pathol 2017 Dec 19;187(12):2645-2658. Epub 2017 Sep 19.

Department of Physiology, VU University Medical Center, Amsterdam, the Netherlands; Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands; Netherlands Heart Institute, Utrecht, the Netherlands.

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http://dx.doi.org/10.1016/j.ajpath.2017.08.022DOI Listing
December 2017

A Comparison of Heritability Estimates by Classical Twin Modeling and Based on Genome-Wide Genetic Relatedness for Cardiac Conduction Traits.

Authors:
Ilja M Nolte Joeri A Jansweijer Hariette Riese Folkert W Asselbergs Pim van der Harst Timothy D Spector Yigal M Pinto Harold Snieder Yalda Jamshidi

Twin Res Hum Genet 2017 12 17;20(6):489-498. Epub 2017 Oct 17.

Genetics Unit,Cardiovascular and Cell Sciences Institute,St George's University of London,London,UK.

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http://dx.doi.org/10.1017/thg.2017.55DOI Listing
December 2017

Targeted Metabolomic Profiling of Plasma and Survival in Heart Failure Patients.

Authors:
David E Lanfear Joseph J Gibbs Jia Li Ruicong She Christopher Petucci Jeffrey A Culver W H Wilson Tang Yigal M Pinto L Keoki Williams Hani N Sabbah Stephen J Gardell

JACC Heart Fail 2017 11;5(11):823-832

Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida.

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http://dx.doi.org/10.1016/j.jchf.2017.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679305PMC
November 2017

Prognostic Value of Serial ST2 Measurements in Patients With Acute Heart Failure.

Authors:
Laura C van Vark Ivonne Lesman-Leegte Sara J Baart Douwe Postmus Yigal M Pinto Joke G Orsel B Daan Westenbrink Hans P Brunner-la Rocca Addy J M van Miltenburg Eric Boersma Hans L Hillege K Martijn Akkerhuis

J Am Coll Cardiol 2017 Nov;70(19):2378-2388

Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands; Cardiovascular Research School, Erasmus Medical Center (COEUR), Rotterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.jacc.2017.09.026DOI Listing
November 2017

Prognostic Value of Serial Galectin-3 Measurements in Patients With Acute Heart Failure.

Authors:
Laura C van Vark Ivonne Lesman-Leegte Sara J Baart Douwe Postmus Yigal M Pinto Rudolf A de Boer Folkert W Asselbergs Elly M C J Wajon Joke G Orsel Eric Boersma Hans L Hillege K Martijn Akkerhuis

J Am Heart Assoc 2017 Nov 29;6(12). Epub 2017 Nov 29.

Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1161/JAHA.116.003700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778986PMC
November 2017

The RNA-binding protein Rbm38 is dispensable during pressure overload-induced cardiac remodeling in mice.

Authors:
Maarten M G van den Hoogenhof Ingeborg van der Made Abdelaziz Beqqali Nina E de Groot Amin Damanafshan Ralph J van Oort Yigal M Pinto Esther E Creemers

PLoS One 2017 29;12(8):e0184093. Epub 2017 Aug 29.

Department of Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184093PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574583PMC
October 2017

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy.

Authors:
Matthias Heinig Michiel E Adriaens Sebastian Schafer Hanneke W M van Deutekom Elisabeth M Lodder James S Ware Valentin Schneider Leanne E Felkin Esther E Creemers Benjamin Meder Hugo A Katus Frank Rühle Monika Stoll François Cambien Eric Villard Philippe Charron Andras Varro Nanette H Bishopric Alfred L George Cristobal Dos Remedios Aida Moreno-Moral Francesco Pesce Anja Bauerfeind Franz Rüschendorf Carola Rintisch Enrico Petretto Paul J Barton Stuart A Cook Yigal M Pinto Connie R Bezzina Norbert Hubner

Genome Biol 2017 09 14;18(1):170. Epub 2017 Sep 14.

Cardiovascular and Metabolic Sciences, Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, Robert-Rössle-Str. 10, 13125, Berlin, Germany.

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http://dx.doi.org/10.1186/s13059-017-1286-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598015PMC
September 2017

Practical data handling pipeline improves performance of qPCR-based circulating miRNA measurements.

Authors:
Maurice W J de Ronde Jan M Ruijter David Lanfear Antoni Bayes-Genis Maayke G M Kok Esther E Creemers Yigal M Pinto Sara-Joan Pinto-Sietsma

RNA 2017 05 15;23(5):811-821. Epub 2017 Feb 15.

Department of Vascular Medicine.

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http://dx.doi.org/10.1261/rna.059063.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393188PMC
May 2017

Truncating titin mutations are associated with a mild and treatable form of dilated cardiomyopathy.

Authors:
Joeri A Jansweijer Karin Nieuwhof Francesco Russo Edgar T Hoorntje Jan D H Jongbloed Ronald H Lekanne Deprez Alex V Postma Marieke Bronk Ingrid A W van Rijsingen Simone de Haij Elena Biagini Paul L van Haelst Jan van Wijngaarden Maarten P van den Berg Arthur A M Wilde Marcel M A M Mannens Rudolf A de Boer Karin Y van Spaendonck-Zwarts J Peter van Tintelen Yigal M Pinto

Eur J Heart Fail 2017 04 3;19(4):512-521. Epub 2016 Nov 3.

AMC Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center Amsterdam, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/ejhf.673DOI Listing
April 2017

Letter by Amin et al Regarding Article, "Genetic Modifiers for the Long-QT Syndrome: How Important Is the Role of Variants in the 3' Untranslated Region of KCNQ1?"

Authors:
Ahmad S Amin Yigal M Pinto Michael J Ackerman Arthur A M Wilde

Circ Cardiovasc Genet 2016 12;9(6):580

Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001629DOI Listing
December 2016

Circulating microRNA biomarkers for cardiovascular risk prediction: are we approaching clinical application?

Authors:
Maurice W J de Ronde Yigal M Pinto Sara-Joan Pinto-Sietsma

Ann Transl Med 2016 Dec;4(24):490

Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.21037/atm.2016.12.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233531PMC
December 2016

A mutation in the glutamate-rich region of RNA-binding motif protein 20 causes dilated cardiomyopathy through missplicing of titin and impaired Frank-Starling mechanism.

Authors:
Abdelaziz Beqqali Ilse A E Bollen Torsten B Rasmussen Maarten M van den Hoogenhof Hanneke W M van Deutekom Sebastian Schafer Jan Haas Benjamin Meder Keld E Sørensen Ralph J van Oort Jens Mogensen Norbert Hubner Esther E Creemers Jolanda van der Velden Yigal M Pinto

Cardiovasc Res 2016 10 5;112(1):452-63. Epub 2016 Aug 5.

Department of Experimental Cardiology, Academic Medical Center, Meibergdreef 15, 1105AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/cvr/cvw192DOI Listing
October 2016

RBM20 Regulates Circular RNA Production From the Titin Gene.

Authors:
Mohsin A F Khan Yolan J Reckman Simona Aufiero Maarten M G van den Hoogenhof Ingeborg van der Made Abdelaziz Beqqali Dave R Koolbergen Torsten B Rasmussen Jolanda van der Velden Esther E Creemers Yigal M Pinto

Circ Res 2016 Oct 16;119(9):996-1003. Epub 2016 Aug 16.

From the Department of Experimental Cardiology (M.A.F.K., Y.J.R., S.A., M.M.G.v.d.H., I.v.d.M., A.B., E.E.C., Y.M.P.), Department of Clinical Epidemiology, Biostatistics and Bioinformatics (M.A.F.K., S.A.), and Department of Cardiothoracic Surgery (D.R.K.), Academic Medical Center, Amsterdam, The Netherlands; Department of Cardiology, Aarhus University Hospital, Denmark (T.B.R.); and Department of Physiology, VU University Medical Center, Amsterdam, The Netherlands (J.v.d.V.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.309568DOI Listing
October 2016

Targeting N-Terminal Pro-Brain Natriuretic Peptide in Older Versus Younger Acute Decompensated Heart Failure Patients.

Authors:
Susan Stienen Khibar Salah Luc W Eurlings Paulo Bettencourt Joana M Pimenta Marco Metra Antoni Bayes-Genis Valerio Verdiani Luca Bettari Valentina Lazzarini Jan P Tijssen Yigal M Pinto Wouter E Kok

JACC Heart Fail 2016 09 6;4(9):736-45. Epub 2016 Jul 6.

Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jchf.2016.05.007DOI Listing
September 2016

52 Genetic Loci Influencing Myocardial Mass.

Authors:
Pim van der Harst Jessica van Setten Niek Verweij Georg Vogler Lude Franke Matthew T Maurano Xinchen Wang Irene Mateo Leach Mark Eijgelsheim Nona Sotoodehnia Caroline Hayward Rossella Sorice Osorio Meirelles Leo-Pekka Lyytikäinen Ozren Polašek Toshiko Tanaka Dan E Arking Sheila Ulivi Stella Trompet Martina Müller-Nurasyid Albert V Smith Marcus Dörr Kathleen F Kerr Jared W Magnani Fabiola Del Greco M Weihua Zhang Ilja M Nolte Claudia T Silva Sandosh Padmanabhan Vinicius Tragante Tõnu Esko Gonçalo R Abecasis Michiel E Adriaens Karl Andersen Phil Barnett Joshua C Bis Rolf Bodmer Brendan M Buckley Harry Campbell Megan V Cannon Aravinda Chakravarti Lin Y Chen Alessandro Delitala Richard B Devereux Pieter A Doevendans Anna F Dominiczak Luigi Ferrucci Ian Ford Christian Gieger Tamara B Harris Eric Haugen Matthias Heinig Dena G Hernandez Hans L Hillege Joel N Hirschhorn Albert Hofman Norbert Hubner Shih-Jen Hwang Annamaria Iorio Mika Kähönen Manolis Kellis Ivana Kolcic Ishminder K Kooner Jaspal S Kooner Jan A Kors Edward G Lakatta Kasper Lage Lenore J Launer Daniel Levy Alicia Lundby Peter W Macfarlane Dalit May Thomas Meitinger Andres Metspalu Stefania Nappo Silvia Naitza Shane Neph Alex S Nord Teresa Nutile Peter M Okin Jesper V Olsen Ben A Oostra Josef M Penninger Len A Pennacchio Tune H Pers Siegfried Perz Annette Peters Yigal M Pinto Arne Pfeufer Maria Grazia Pilia Peter P Pramstaller Bram P Prins Olli T Raitakari Soumya Raychaudhuri Ken M Rice Elizabeth J Rossin Jerome I Rotter Sebastian Schafer David Schlessinger Carsten O Schmidt Jobanpreet Sehmi Herman H W Silljé Gianfranco Sinagra Moritz F Sinner Kamil Slowikowski Elsayed Z Soliman Timothy D Spector Wilko Spiering John A Stamatoyannopoulos Ronald P Stolk Konstantin Strauch Sian-Tsung Tan Kirill V Tarasov Bosco Trinh Andre G Uitterlinden Malou van den Boogaard Cornelia M van Duijn Wiek H van Gilst Jorma S Viikari Peter M Visscher Veronique Vitart Uwe Völker Melanie Waldenberger Christian X Weichenberger Harm-Jan Westra Cisca Wijmenga Bruce H Wolffenbuttel Jian Yang Connie R Bezzina Patricia B Munroe Harold Snieder Alan F Wright Igor Rudan Laurie A Boyer Folkert W Asselbergs Dirk J van Veldhuisen Bruno H Stricker Bruce M Psaty Marina Ciullo Serena Sanna Terho Lehtimäki James F Wilson Stefania Bandinelli Alvaro Alonso Paolo Gasparini J Wouter Jukema Stefan Kääb Vilmundur Gudnason Stephan B Felix Susan R Heckbert Rudolf A de Boer Christopher Newton-Cheh Andrew A Hicks John C Chambers Yalda Jamshidi Axel Visel Vincent M Christoffels Aaron Isaacs Nilesh J Samani Paul I W de Bakker

J Am Coll Cardiol 2016 09;68(13):1435-1448

Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Epidemiology, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1016/j.jacc.2016.07.729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478167PMC
September 2016

Resveratrol Inhibits Aortic Root Dilatation in the Fbn1C1039G/+ Marfan Mouse Model.

Authors:
Stijntje Hibender Romy Franken Cindy van Roomen Anique Ter Braake Ingeborg van der Made Edith E Schermer Quinn Gunst Maurice J van den Hoff Esther Lutgens Yigal M Pinto Maarten Groenink Aeilko H Zwinderman Barbara J M Mulder Carlie J M de Vries Vivian de Waard

Arterioscler Thromb Vasc Biol 2016 08 9;36(8):1618-26. Epub 2016 Jun 9.

From the Department of Medical Biochemistry (S.H., C.v.R., A.t.B., E.E.S., E.L., C.J.M.d.V., V.d.W.), Department of Cardiology (R.F., M.G., B.J.M.M.), Department of Experimental Cardiology (I.v.d.M., Y.M.P.), Heart Failure Research Center (Q.G., M.J.v.d.H.), Department of Radiology (M.G.), Department of Clinical Epidemiology and Biostatistics (A.H.Z.), Academic Medical Center, Amsterdam, The Netherlands; and Institute for Cardiovascular Prevention (IPEK) and Ludwig Maximilians University, Munich, Germany (E.L.).

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http://dx.doi.org/10.1161/ATVBAHA.116.307841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961273PMC
August 2016

Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing.

Authors:
Jérôme Nicod Robert W Davies Na Cai Carl Hassett Leo Goodstadt Cormac Cosgrove Benjamin K Yee Vikte Lionikaite Rebecca E McIntyre Carol Ann Remme Elisabeth M Lodder Jennifer S Gregory Tertius Hough Russell Joynson Hayley Phelps Barbara Nell Clare Rowe Joe Wood Alison Walling Nasrin Bopp Amarjit Bhomra Polinka Hernandez-Pliego Jacques Callebert Richard M Aspden Nick P Talbot Peter A Robbins Mark Harrison Martin Fray Jean-Marie Launay Yigal M Pinto David A Blizard Connie R Bezzina David J Adams Paul Franken Tom Weaver Sara Wells Steve D M Brown Paul K Potter Paul Klenerman Arimantas Lionikas Richard Mott Jonathan Flint

Nat Genet 2016 08 4;48(8):912-8. Epub 2016 Jul 4.

Wellcome Trust Centre for Human Genetics, Oxford, UK.

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http://dx.doi.org/10.1038/ng.3595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966644PMC
August 2016

Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases.

Authors:
Yigal M Pinto Perry M Elliott Eloisa Arbustini Yehuda Adler Aris Anastasakis Michael Böhm Denis Duboc Juan Gimeno Pascal de Groote Massimo Imazio Stephane Heymans Karin Klingel Michel Komajda Giuseppe Limongelli Ales Linhart Jens Mogensen James Moon Petronella G Pieper Petar M Seferovic Stephan Schueler Jose L Zamorano Alida L P Caforio Philippe Charron

Eur Heart J 2016 06 19;37(23):1850-8. Epub 2016 Jan 19.

Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.

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http://dx.doi.org/10.1093/eurheartj/ehv727DOI Listing
June 2016

MicroRNAs in heart failure: from biomarker to target for therapy.

Authors:
Eline L Vegter Peter van der Meer Leon J de Windt Yigal M Pinto Adriaan A Voors

Eur J Heart Fail 2016 05 11;18(5):457-68. Epub 2016 Feb 11.

Department of Cardiology, University Medical Centre Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.

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http://dx.doi.org/10.1002/ejhf.495DOI Listing
May 2016

Signature of circulating microRNAs in patients with acute heart failure.

Authors:
Ekaterina S Ovchinnikova Daniela Schmitter Eline L Vegter Jozine M Ter Maaten Mattia A E Valente Licette C Y Liu Pim van der Harst Yigal M Pinto Rudolf A de Boer Sven Meyer John R Teerlink Christopher M O'Connor Marco Metra Beth A Davison Daniel M Bloomfield Gadi Cotter John G Cleland Alexandre Mebazaa Said Laribi Michael M Givertz Piotr Ponikowski Peter van der Meer Dirk J van Veldhuisen Adriaan A Voors Eugene Berezikov

Eur J Heart Fail 2016 04 8;18(4):414-23. Epub 2015 Sep 8.

European Research Institute for the Biology of Ageing and University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1002/ejhf.332DOI Listing
April 2016

Reply: Worsening Renal Function in Acute Decompensated Heart Failure: The Puzzle is Still Incomplete.

Authors:
Khibar Salah Wouter E Kok Yigal M Pinto

JACC Heart Fail 2016 Mar;4(3):233-4

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http://dx.doi.org/10.1016/j.jchf.2015.12.002DOI Listing
March 2016

A targeted metabolomics assay for cardiac metabolism and demonstration using a mouse model of dilated cardiomyopathy.

Authors:
James A West Abdelaziz Beqqali Zsuzsanna Ament Perry Elliott Yigal M Pinto Eloisa Arbustini Julian L Griffin

Metabolomics 2016;12:59. Epub 2016 Mar 7.

The Department of Biochemistry & The Cambridge Systems Biology Centre, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA UK ; The Elsie Widdowson Laboratory, Medical Research Council Human Nutrition Research, 120 Fulbourn Road, Cambridge, CB1 9NL UK.

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http://dx.doi.org/10.1007/s11306-016-0956-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781888PMC
March 2016

Genome-Wide Polyadenylation Maps Reveal Dynamic mRNA 3'-End Formation in the Failing Human Heart.

Authors:
Esther E Creemers Amira Bawazeer Alejandro P Ugalde Hanneke W M van Deutekom Ingeborg van der Made Nina E de Groot Michiel E Adriaens Stuart A Cook Connie R Bezzina Norbert Hubner Jolanda van der Velden Ran Elkon Reuven Agami Yigal M Pinto

Circ Res 2016 Feb 15;118(3):433-8. Epub 2015 Dec 15.

From the Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands (E.E.C., A.B., H.W.M.D., I.M., N.E.G., M.E.A., C.R.B., Y.M.P.); Division of Biological Stress Response, The Netherlands Cancer Institute, Amsterdam, The Netherlands (A.P.U., R.E., R.A.); National Heart and Lung Institute, Imperial College, London, United Kingdom (S.A.C.); Cardiovascular and Metabolic Sciences, Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany (N.H.); and Department of Physiology, VU University Medical Center, Amsterdam, The Netherlands (J.V.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.307082DOI Listing
February 2016

RNA Splicing: Regulation and Dysregulation in the Heart.

Authors:
Maarten M G van den Hoogenhof Yigal M Pinto Esther E Creemers

Circ Res 2016 Feb;118(3):454-68

From the Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCRESAHA.115.307872DOI Listing
February 2016

MicroRNAs relate to early worsening of renal function in patients with acute heart failure.

Authors:
Noemi Bruno Jozine M ter Maaten Ekaterina S Ovchinnikova Eline L Vegter Mattia A E Valente Peter van der Meer Rudolf A de Boer Pim van der Harst Daniela Schmitter Marco Metra Christopher M O'Connor Piotr Ponikowski John R Teerlink Gad Cotter Beth Davison John G Cleland Michael M Givertz Daniel M Bloomfield Howard C Dittrich Yigal M Pinto Dirk J van Veldhuisen Hans L Hillege Eugene Berezikov Adriaan A Voors

Int J Cardiol 2016 Jan 11;203:564-9. Epub 2015 Nov 11.

University of Groningen, Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2015.10.217DOI Listing
January 2016

Which heart failure patients profit from natriuretic peptide guided therapy? A meta-analysis from individual patient data of randomized trials.

Authors:
Hans-Peter Brunner-La Rocca Luc Eurlings A Mark Richards James L Januzzi Matthias E Pfisterer Ulf Dahlström Yigal M Pinto Patric Karlström Hans Erntell Rudolf Berger Hans Persson Christopher M O'Connor Deddo Moertl Hanna K Gaggin Christopher M Frampton M Gary Nicholls Richard W Troughton

Eur J Heart Fail 2015 Dec 30;17(12):1252-61. Epub 2015 Sep 30.

Department of Medicine, University of Otago Christchurch, Christchurch Hospital, Christchurch, New Zealand.

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http://dx.doi.org/10.1002/ejhf.401DOI Listing
December 2015

N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) Measurements Until a 30% Reduction Is Attained During Acute Decompensated Heart Failure Admissions and Comparison With Discharge NT-proBNP Levels: Implications for In-Hospital Guidance of Treatment.

Authors:
Susan Stienen Khibar Salah Cathelijne Dickhoff Valentina Carubelli Marco Metra Laura Magrini Salvatore Di Somma Jan P Tijssen Yigal M Pinto Wouter E Kok

J Card Fail 2015 Nov 26;21(11):930-4. Epub 2015 Jul 26.

Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cardfail.2015.07.011DOI Listing
November 2015

Competing Risk of Cardiac Status and Renal Function During Hospitalization for Acute Decompensated Heart Failure.

Authors:
Khibar Salah Wouter E Kok Luc W Eurlings Paulo Bettencourt Joana M Pimenta Marco Metra Valerio Verdiani Jan G Tijssen Yigal M Pinto

JACC Heart Fail 2015 Oct;3(10):751-61

Heart Failure Research Center and Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jchf.2015.05.009DOI Listing
October 2015

Challenging the two concepts in determining the appropriate pre-discharge N-terminal pro-brain natriuretic peptide treatment target in acute decompensated heart failure patients: absolute or relative discharge levels?

Authors:
Susan Stienen Khibar Salah Luc W M Eurlings Paulo Bettencourt Joana M Pimenta Marco Metra Antoni Bayes-Genis Valerio Verdiani Luca Bettari Valentina Lazzarini Jan P Tijssen Yigal M Pinto Wouter E M Kok

Eur J Heart Fail 2015 Sep 29;17(9):936-44. Epub 2015 Jul 29.

Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/ejhf.320DOI Listing
September 2015

Serum potassium decline during hospitalization for acute decompensated heart failure is a predictor of 6-month mortality, independent of N-terminal pro-B-type natriuretic peptide levels: An individual patient data analysis.

Authors:
Khibar Salah Yigal M Pinto Luc W Eurlings Marco Metra Susan Stienen Carlo Lombardi Jan G Tijssen Wouter E Kok

Am Heart J 2015 Sep 10;170(3):531-42.e1. Epub 2015 Jun 10.

Academic Medical Center, University of Amsterdam, Heart failure Research Center & Department of Cardiology, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.ahj.2015.06.003DOI Listing
September 2015

Cardiomyocyte-specific miRNA-30c over-expression causes dilated cardiomyopathy.

Authors:
Wino J Wijnen Ingeborg van der Made Stephanie van den Oever Monika Hiller Bouke A de Boer Daisy I Picavet Iliana A Chatzispyrou Riekelt H Houtkooper Anke J Tijsen Jaco Hagoort Henk van Veen Vincent Everts Jan M Ruijter Yigal M Pinto Esther E Creemers

PLoS One 2014 2;9(5):e96290. Epub 2014 May 2.

Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096290PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008570PMC
June 2015

Atlas of the clinical genetics of human dilated cardiomyopathy.

Authors:
Jan Haas Karen S Frese Barbara Peil Wanda Kloos Andreas Keller Rouven Nietsch Zhu Feng Sabine Müller Elham Kayvanpour Britta Vogel Farbod Sedaghat-Hamedani Wei-Keat Lim Xiaohong Zhao Dmitriy Fradkin Doreen Köhler Simon Fischer Jennifer Franke Sabine Marquart Ioana Barb Daniel Tian Li Ali Amr Philipp Ehlermann Derliz Mereles Tanja Weis Sarah Hassel Andreas Kremer Vanessa King Emil Wirsz Richard Isnard Michel Komajda Alessandra Serio Maurizia Grasso Petros Syrris Eleanor Wicks Vincent Plagnol Luis Lopes Tenna Gadgaard Hans Eiskjær Mads Jørgensen Diego Garcia-Giustiniani Martin Ortiz-Genga Maria G Crespo-Leiro Rondal H Lekanne Dit Deprez Imke Christiaans Ingrid A van Rijsingen Arthur A Wilde Anders Waldenstrom Martino Bolognesi Riccardo Bellazzi Stellan Mörner Justo Lorenzo Bermejo Lorenzo Monserrat Eric Villard Jens Mogensen Yigal M Pinto Philippe Charron Perry Elliott Eloisa Arbustini Hugo A Katus Benjamin Meder

Eur Heart J 2015 May 27;36(18):1123-35a. Epub 2014 Aug 27.

Department of Internal Medicine III, University of Heidelberg, Germany DZHK (German Centre for Cardiovascular Research), Germany Klaus Tschira Institute for Computational Cardiology, University of Heidelberg, Germany

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https://academic.oup.com/eurheartj/article-lookup/doi/10.109
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http://dx.doi.org/10.1093/eurheartj/ehu301DOI Listing
May 2015

Risk stratification with the use of serial N-terminal pro-B-type natriuretic peptide measurements during admission and early after discharge in heart failure patients: post hoc analysis of the PRIMA study.

Authors:
Luc W Eurlings Sandra Sanders-van Wijk Dave J W van Kraaij Roland van Kimmenade Joan G Meeder Otto Kamp Marja P van Dieijen-Visser Jan G P Tijssen Hans-Peter Brunner-La Rocca Yigal M Pinto

J Card Fail 2014 Dec 28;20(12):881-90. Epub 2014 Aug 28.

Department of Cardiology, Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.cardfail.2014.08.014DOI Listing
December 2014

The microRNA-15 family inhibits the TGFβ-pathway in the heart.

Authors:
Anke J Tijsen Ingeborg van der Made Maarten M van den Hoogenhof Wino J Wijnen Elza D van Deel Nina E de Groot Sergey Alekseev Kees Fluiter Blanche Schroen Marie-José Goumans Jolanda van der Velden Dirk J Duncker Yigal M Pinto Esther E Creemers

Cardiovasc Res 2014 Oct 7;104(1):61-71. Epub 2014 Aug 7.

Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands

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http://dx.doi.org/10.1093/cvr/cvu184DOI Listing
October 2014

Outcome in phospholamban R14del carriers: results of a large multicentre cohort study.

Authors:
Ingrid A W van Rijsingen Paul A van der Zwaag Judith A Groeneweg Eline A Nannenberg Jan D H Jongbloed Aeilko H Zwinderman Yigal M Pinto Ronald H Lekanne Dit Deprez Jan G Post Hanno L Tan Rudolf A de Boer Richard N W Hauer Imke Christiaans Maarten P van den Berg J Peter van Tintelen Arthur A M Wilde

Circ Cardiovasc Genet 2014 Aug 8;7(4):455-65. Epub 2014 Jun 8.

Departments of Cardiology (I.A.W.v.R., Y.M.P., H.L.T., A.A.M.W.), Genetics (E.A.N., R.H.L.d.D., I.C.), and Epidemiology (A.H.Z.), Academic Medical Center, Amsterdam, The Netherlands; Departments of Genetics (P.A.v.d.Z., J.D.H.J., J.P.v.T.) and Cardiology (R.A.d.B., M.P.v.d.B.), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands (J.A.G., Y.M.P., R.N.W.H., A.A.M.W.); Departments of Cardiology (J.A.G., R.N.W.H.) and Genetics (J.G.P.), University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1161/CIRCGENETICS.113.000374DOI Listing
August 2014

HCN4 mutations in multiple families with bradycardia and left ventricular noncompaction cardiomyopathy.

Authors:
Annalisa Milano Alexa M C Vermeer Elisabeth M Lodder Julien Barc Arie O Verkerk Alex V Postma Ivo A C van der Bilt Marieke J H Baars Paul L van Haelst Kadir Caliskan Yvonne M Hoedemaekers Solena Le Scouarnec Richard Redon Yigal M Pinto Imke Christiaans Arthur A Wilde Connie R Bezzina

J Am Coll Cardiol 2014 Aug;64(8):745-56

Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2014.05.045DOI Listing
August 2014

Rationale and design of PRIMA II: A multicenter, randomized clinical trial to study the impact of in-hospital guidance for acute decompensated heart failure treatment by a predefined NT-PRoBNP target on the reduction of readmIssion and Mortality rAtes.

Authors:
Susan Stienen Khibar Salah Andreas H M Moons Adrianus L M Bakx Petra E van Pol Jutta M Schroeder-Tanka Albertus J Voogel Jan T Keijer R A Mikael Kortz Cathelijne Dickhoff Paola G Meregalli Jan G Tijssen Yigal M Pinto Wouter E Kok

Am Heart J 2014 Jul 23;168(1):30-6. Epub 2014 Apr 23.

Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ahj.2014.04.008DOI Listing
July 2014

Effect of B-type natriuretic peptide-guided treatment of chronic heart failure on total mortality and hospitalization: an individual patient meta-analysis.

Authors:
Richard W Troughton Christopher M Frampton Hans-Peter Brunner-La Rocca Matthias Pfisterer Luc W M Eurlings Hans Erntell Hans Persson Christopher M O'Connor Deddo Moertl Patric Karlström Ulf Dahlström Hanna K Gaggin James L Januzzi Rudolf Berger A Mark Richards Yigal M Pinto M Gary Nicholls

Eur Heart J 2014 Jun 6;35(23):1559-67. Epub 2014 Mar 6.

Department of Medicine, University of Otago Christchurch, Christchurch Hospital, PO Box 4345, Christchurch 8140, New Zealand.

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http://dx.doi.org/10.1093/eurheartj/ehu090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057643PMC
June 2014

A novel discharge risk model for patients hospitalised for acute decompensated heart failure incorporating N-terminal pro-B-type natriuretic peptide levels: a European coLlaboration on Acute decompeNsated Heart Failure: ELAN-HF Score.

Authors:
Khibar Salah Wouter E Kok Luc W Eurlings Paulo Bettencourt Joana M Pimenta Marco Metra Antoni Bayes-Genis Valerio Verdiani Luca Bettari Valentina Lazzarini Peter Damman Jan G Tijssen Yigal M Pinto

Heart 2014 Jan 31;100(2):115-25. Epub 2013 Oct 31.

Heart failure Research Center & Department of Cardiology, Academic Medical Center, University of Amsterdam, , Amsterdam, The Netherlands.

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http://dx.doi.org/10.1136/heartjnl-2013-303632DOI Listing
January 2014

The therapeutic potential of miRNAs in cardiac fibrosis: where do we stand?

Authors:
Wino J Wijnen Yigal M Pinto Esther E Creemers

J Cardiovasc Transl Res 2013 Dec 3;6(6):899-908. Epub 2013 Jul 3.

Heart Failure Research Center, Academic Medical Center, Meibergdreef 15, 1015 AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s12265-013-9483-yDOI Listing
December 2013

The LMNA mutation p.Arg321Ter associated with dilated cardiomyopathy leads to reduced expression and a skewed ratio of lamin A and lamin C proteins.

Authors:
Rasha Al-Saaidi Torsten B Rasmussen Johan Palmfeldt Peter H Nissen Abdelaziz Beqqali Jakob Hansen Yigal M Pinto Thomas Boesen Jens Mogensen Peter Bross

Exp Cell Res 2013 Nov 31;319(19):3010-9. Epub 2013 Aug 31.

Research Unit for Molecular Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1016/j.yexcr.2013.08.024DOI Listing
November 2013

Lamin A/C mutation is independently associated with an increased risk of arterial and venous thromboembolic complications.

Authors:
Ingrid A W van Rijsingen Annemieke Bakker Donija Azim Johanna F Hermans-van Ast Anneke J van der Kooi J Peter van Tintelen Maarten P van den Berg Imke Christiaans Ronald H Lekanne Dit Deprez Arthur A M Wilde Aeilko H Zwinderman Joost C M Meijers Anita E Grootemaat Rienk Nieuwland Yigal M Pinto Sara-Joan Pinto-Sietsma

Int J Cardiol 2013 Sep 14;168(1):472-7. Epub 2012 Oct 14.

ICIN Netherlands Heart Institute/Durrer Center for Cardiogenetic Research, The Netherlands.

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http://dx.doi.org/10.1016/j.ijcard.2012.09.118DOI Listing
September 2013

Long QT syndrome: beyond the causal mutation.

Authors:
Ahmad S Amin Yigal M Pinto Arthur A M Wilde

J Physiol 2013 Sep 10;591(17):4125-39. Epub 2013 Jun 10.

A. A. M. Wilde: Department of Cardiology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1113/jphysiol.2013.254920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779107PMC
September 2013

Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases.

Authors:
Alida L P Caforio Sabine Pankuweit Eloisa Arbustini Cristina Basso Juan Gimeno-Blanes Stephan B Felix Michael Fu Tiina Heliö Stephane Heymans Roland Jahns Karin Klingel Ales Linhart Bernhard Maisch William McKenna Jens Mogensen Yigal M Pinto Arsen Ristic Heinz-Peter Schultheiss Hubert Seggewiss Luigi Tavazzi Gaetano Thiene Ali Yilmaz Philippe Charron Perry M Elliott

Eur Heart J 2013 Sep 3;34(33):2636-48, 2648a-2648d. Epub 2013 Jul 3.

Division of Cardiology, Department of Cardiological Thoracic and Vascular Sciences, University of Padua, Padova, Italy.

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http://eurheartj.oxfordjournals.org/cgi/doi/10.1093/eurheart
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http://dx.doi.org/10.1093/eurheartj/eht210DOI Listing
September 2013

Macrophage microRNA-155 promotes cardiac hypertrophy and failure.

Authors:
Stephane Heymans Maarten F Corsten Wouter Verhesen Paolo Carai Rick E W van Leeuwen Kevin Custers Tim Peters Mark Hazebroek Lauran Stöger Erwin Wijnands Ben J Janssen Esther E Creemers Yigal M Pinto Dirk Grimm Nina Schürmann Elena Vigorito Thomas Thum Frank Stassen Xiaoke Yin Manuel Mayr Leon J de Windt Esther Lutgens Kristiaan Wouters Menno P J de Winther Serena Zacchigna Mauro Giacca Marc van Bilsen Anna-Pia Papageorgiou Blanche Schroen

Circulation 2013 Sep 16;128(13):1420-32. Epub 2013 Aug 16.

Center for Heart Failure Research, Department of Cardiology (S.H., M.F.C., W.V., P.C., R.E.W.v.L., K.C., T.P., M.H., M.v.B., A.-P.P., B.S.), Department of Molecular Genetics (L.S., M.P.J.d.W.), Department of Pathology (E.W., E.L.), Department of Pharmacology (B.J.J.), Department of Cardiology (L.J.d.W.), and Department of Internal Medicine (K.W.), Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands (S.H.); Center for Molecular and Cardiovascular Biology, Department of Cardiovascular Sciences, Leuven, Belgium (S.H., P.C., A.-P.P.); Department of Medical Biochemistry (L.S., E.L., M.P.J.d.W.) and Heart Failure Research Center (E.E.C., Y.M.P.), Academic Medical Center, Amsterdam, the Netherlands; Cluster of Excellence Cell Networks, Department of Infectious Diseases/Virology, Virus Host Interactions, Heidelberg University, Heidelberg, Germany (D.G., N.S.); Laboratory of Lymphocyte Signaling and Development, Babraham Institute, Cambridge, UK (E.V.); Institute for Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany (T.T.); Medical Microbiology, Maastricht University, Maastricht, the Netherlands (F.S.); King's BHF Centre, King's College London, London UK (X.Y., M.M.); Institute for Cardiovascular Prevention, Ludwig Maximilians University, Munich, Germany (E.L.); and Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy (S.Z., M.G.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.001357DOI Listing
September 2013

The hypoxia-inducible microRNA cluster miR-199a∼214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation.

Authors:
Hamid el Azzouzi Stefanos Leptidis Ellen Dirkx Joris Hoeks Bianca van Bree Karl Brand Elizabeth A McClellan Ella Poels Judith C Sluimer Maarten M G van den Hoogenhof Anne-Sophie Armand Xiaoke Yin Sarah Langley Meriem Bourajjaj Serve Olieslagers Jaya Krishnan Marc Vooijs Hiroki Kurihara Andrew Stubbs Yigal M Pinto Wilhelm Krek Manuel Mayr Paula A da Costa Martins Patrick Schrauwen Leon J De Windt

Cell Metab 2013 Sep;18(3):341-54

Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, 6229 ER Maastricht, the Netherlands; Department of Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.

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http://dx.doi.org/10.1016/j.cmet.2013.08.009DOI Listing
September 2013

Genetic analysis in 418 index patients with idiopathic dilated cardiomyopathy: overview of 10 years' experience.

Authors:
Karin Y van Spaendonck-Zwarts Ingrid A W van Rijsingen Maarten P van den Berg Ronald H Lekanne Deprez Jan G Post Anneke M van Mil Folkert W Asselbergs Imke Christiaans Irene M van Langen Arthur A M Wilde Rudolf A de Boer Jan D H Jongbloed Yigal M Pinto J Peter van Tintelen

Eur J Heart Fail 2013 Jun 24;15(6):628-36. Epub 2013 Jan 24.

Department of Genetics, University of Groningen, University Medical Centre Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands.

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http://dx.doi.org/10.1093/eurjhf/hft013DOI Listing
June 2013

Gender-specific differences in major cardiac events and mortality in lamin A/C mutation carriers.

Authors:
Ingrid A W van Rijsingen Eline A Nannenberg Eloisa Arbustini Perry M Elliott Jens Mogensen Johanna F Hermans-van Ast Anneke J van der Kooi J Peter van Tintelen Maarten P van den Berg Maurizia Grasso Alessandra Serio Sharon Jenkins Camilla Rowland Pascale Richard Arthur A M Wilde Andreas Perrot Sabine Pankuweit Aeilko H Zwinderman Philippe Charron Imke Christiaans Yigal M Pinto

Eur J Heart Fail 2013 Apr 25;15(4):376-84. Epub 2012 Nov 25.

Department of Cardiology (Heart Failure Research Center), Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/eurjhf/hfs191DOI Listing
April 2013

Circulating microRNAs as diagnostic biomarkers for cardiovascular diseases.

Authors:
Anke J Tijsen Yigal M Pinto Esther E Creemers

Am J Physiol Heart Circ Physiol 2012 Nov 31;303(9):H1085-95. Epub 2012 Aug 31.

Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1152/ajpheart.00191.2012DOI Listing
November 2012

Multimarker strategy for short-term risk assessment in patients with dyspnea in the emergency department: the MARKED (Multi mARKer Emergency Dyspnea)-risk score.

Authors:
Luc W Eurlings Sandra Sanders-van Wijk Roland van Kimmenade Aart Osinski Lidwien van Helmond Maud Vallinga Harry J Crijns Marja P van Dieijen-Visser Hans-Peter Brunner-La Rocca Yigal M Pinto

J Am Coll Cardiol 2012 Oct 26;60(17):1668-77. Epub 2012 Sep 26.

Department of Cardiology, Maastricht University Medical Center, CARIM, Maastricht, the Netherlands.

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http://dx.doi.org/10.1016/j.jacc.2012.06.040DOI Listing
October 2012

Repression of cardiac hypertrophy by KLF15: underlying mechanisms and therapeutic implications.

Authors:
Joost J Leenders Wino J Wijnen Ingeborg van der Made Monika Hiller Melissa Swinnen Thierry Vandendriessche Marinee Chuah Yigal M Pinto Esther E Creemers

PLoS One 2012 7;7(5):e36754. Epub 2012 May 7.

Heart Failure Research Center, AMC, University of Amsterdam, Amsterdam, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346753PMC
September 2012

Structural and functional cardiac changes in myotonic dystrophy type 1: a cardiovascular magnetic resonance study.

Authors:
Mieke C E Hermans Catharina G Faber Sebastiaan C A M Bekkers Christine E M de Die-Smulders Monique M Gerrits Ingemar S J Merkies Gabriel Snoep Yigal M Pinto Simon Schalla

J Cardiovasc Magn Reson 2012 Jul 24;14:48. Epub 2012 Jul 24.

Department of Neurology, Maastricht University Medical Centre, PO box 5800, Maastricht, AZ, 6202, The Netherlands.

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http://dx.doi.org/10.1186/1532-429X-14-48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461413PMC
July 2012

Post-natal myogenic and adipogenic developmental: defects and metabolic impairment upon loss of A-type lamins.

Authors:
Nard Kubben Jan Willem Voncken Gonda Konings Michel van Weeghel Maarten Mg van den Hoogenhof Marion Gijbels Arie van Erk Kees Schoonderwoerd Bianca van den Bosch Vivian Dahlmans Chantal Calis Sander M Houten Tom Misteli Yigal M Pinto

Nucleus 2011 May-Jun;2(3):195-207

Heart Failure Research Center and Department of Cardiology, Maastricht University Medical Centre, The Netherlands.

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http://dx.doi.org/10.4161/nucl.2.3.15731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149880PMC
April 2012

Non-cardiomyocyte microRNAs in heart failure.

Authors:
Anke J Tijsen Yigal M Pinto Esther E Creemers

Cardiovasc Res 2012 Mar 16;93(4):573-82. Epub 2011 Dec 16.

Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/cvr/cvr344DOI Listing
March 2012

Variants in the 3' untranslated region of the KCNQ1-encoded Kv7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner.

Authors:
Ahmad S Amin John R Giudicessi Anke J Tijsen Anne M Spanjaart Yolan J Reckman Christine A Klemens Michael W Tanck Jamie D Kapplinger Nynke Hofman Moritz F Sinner Martina Müller Wino J Wijnen Hanno L Tan Connie R Bezzina Esther E Creemers Arthur A M Wilde Michael J Ackerman Yigal M Pinto

Eur Heart J 2012 Mar 23;33(6):714-23. Epub 2011 Dec 23.

Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1093/eurheartj/ehr473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303714PMC
March 2012

Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease?

Authors:
Esther E Creemers Anke J Tijsen Yigal M Pinto

Circ Res 2012 Feb;110(3):483-95

Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Netherlands.

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http://dx.doi.org/10.1161/CIRCRESAHA.111.247452DOI Listing
February 2012

Troponin T measurements by high-sensitivity vs conventional assays for risk stratification in acute dyspnea.

Authors:
Sandra van Wijk Leo Jacobs Luc W Eurlings Roland van Kimmenade Roosmarijn Lemmers Pieter Broos Otto Bekers Martin H Prins Harry J Crijns Yigal M Pinto Marja P van Dieijen-Visser Hans-Peter Brunner-La Rocca

Clin Chem 2012 Jan 18;58(1):284-92. Epub 2011 Nov 18.

Department of Cardiology, Maastricht University Medical Center, CARIM, Maastricht, the Netherlands.

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http://dx.doi.org/10.1373/clinchem.2011.175976DOI Listing
January 2012

Risk factors for malignant ventricular arrhythmias in lamin a/c mutation carriers a European cohort study.

Authors:
Ingrid A W van Rijsingen Eloisa Arbustini Perry M Elliott Jens Mogensen Johanna F Hermans-van Ast Anneke J van der Kooi J Peter van Tintelen Maarten P van den Berg Andrea Pilotto Michele Pasotti Sharon Jenkins Camilla Rowland Uzma Aslam Arthur A M Wilde Andreas Perrot Sabine Pankuweit Aeilko H Zwinderman Philippe Charron Yigal M Pinto

J Am Coll Cardiol 2012 Jan;59(5):493-500

Department of Cardiology, Heart Failure Research Center, Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.jacc.2011.08.078DOI Listing
January 2012

Absence of thrombospondin-2 increases cardiomyocyte damage and matrix disruption in doxorubicin-induced cardiomyopathy.

Authors:
Geert C van Almen Melissa Swinnen Paolo Carai Wouter Verhesen Jack P M Cleutjens Jan D'hooge Fons K Verheyen Yigal M Pinto Blanche Schroen Peter Carmeliet Stephane Heymans

J Mol Cell Cardiol 2011 Sep 23;51(3):318-28. Epub 2011 May 23.

Center for Heart Failure Research, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 5800, 6202 AZ Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.yjmcc.2011.05.010DOI Listing
September 2011

Clinical utility gene card for: hypertrophic cardiomyopathy (type 1-14).

Authors:
Yigal M Pinto Arthur Aam Wilde Ingrid Aw van Rijsingen Imke Christiaans Ronald H Lekanne Deprez Perry M Elliott

Eur J Hum Genet 2011 Aug 26;19(8). Epub 2011 Jan 26.

Heart Failure Research Centre, Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/ejhg.2010.243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172916PMC
August 2011

Tapping the brake on cardiac growth-endogenous repressors of hypertrophic signaling.

Authors:
Joost J Leenders Yigal M Pinto Esther E Creemers

J Mol Cell Cardiol 2011 Aug 7;51(2):156-67. Epub 2011 May 7.

Heart Failure Research Center, Academic Medical Center, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands.

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August 2011

[Ambiguities in the diagnosis of heart failure].

Authors:
Ingrid A W van Rijsingen Yigal M Pinto Wouter E M Kok

Ned Tijdschr Geneeskd 2011 ;155:A3159

Academisch Medisch Centrum, afd. Cardiologie, Amsterdam, the Netherlands.

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July 2011

A complex double deletion in LMNA underlies progressive cardiac conduction disease, atrial arrhythmias, and sudden death.

Authors:
Roos F Marsman Abdennasser Bardai Alex V Postma Jan C J Res Tamara T Koopmann Leander Beekman Allard C van der Wal Yigal M Pinto Ronald H Lekanne Deprez Arthur A M Wilde Luc J Jordaens Connie R Bezzina

Circ Cardiovasc Genet 2011 Jun 15;4(3):280-7. Epub 2011 Mar 15.

Heart Failure Research Center, Department of Experimental Cardiology, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCGENETICS.110.959221DOI Listing
June 2011

Pivotal role of cardiomyocyte TGF-β signaling in the murine pathological response to sustained pressure overload.

Authors:
Norimichi Koitabashi Thomas Danner Ari L Zaiman Yigal M Pinto Janelle Rowell Joseph Mankowski Dou Zhang Taishi Nakamura Eiki Takimoto David A Kass

J Clin Invest 2011 Jun 2;121(6):2301-12. Epub 2011 May 2.

Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1172/JCI44824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104748PMC
June 2011

Heart failure: advances through genomics.

Authors:
Esther E Creemers Arthur A Wilde Yigal M Pinto

Nat Rev Genet 2011 05 22;12(5):357-62. Epub 2011 Mar 22.

The Heart Failure Research Center, Room K2-120, Academic Medical Center (AMC), Meibergdreef 15, 1105AZ Amsterdam, The Netherlands.

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http://www.nature.com/articles/nrg2983
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May 2011

Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart.

Authors:
Esther E Creemers Yigal M Pinto

Cardiovasc Res 2011 Feb 28;89(2):265-72. Epub 2010 Sep 28.

Heart Failure Research Center, Academic Medical Center, Meibergdreef 15, Room L2-108-3, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/cvr/cvq308DOI Listing
February 2011

Management of chronic heart failure guided by individual N-terminal pro-B-type natriuretic peptide targets: results of the PRIMA (Can PRo-brain-natriuretic peptide guided therapy of chronic heart failure IMprove heart fAilure morbidity and mortality?) study.

Authors:
Luc W M Eurlings Petra E J van Pol Wouter E Kok Sandra van Wijk Cara Lodewijks-van der Bolt Aggie H M M Balk Dirk J A Lok Harry J G M Crijns Dave J W van Kraaij Nicolaas de Jonge Joan G Meeder Martin Prins Yigal M Pinto

J Am Coll Cardiol 2010 Dec;56(25):2090-100

Maastricht University Medical Center, Maastricht, the Netherlands.

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http://dx.doi.org/10.1016/j.jacc.2010.07.030DOI Listing
December 2010

Ultrastructural pathology of the nuclear envelope in familial lamin A/C cardiomyopathy.

Authors:
Gilles F Diercks J Peter van Tintelen Rene A Tio Wilhelmina S Kerstjens-Frederikse Yigal M Pinto Albert J Suurmeijer

Cardiovasc Pathol 2010 Jul-Aug;19(4):e135-6. Epub 2009 Apr 16.

Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.carpath.2009.03.001DOI Listing
October 2010

Regulation of cardiac gene expression by KLF15, a repressor of myocardin activity.

Authors:
Joost J Leenders Wino J Wijnen Monika Hiller Ingeborg van der Made Viola Lentink Rick E W van Leeuwen Veronica Herias Saraswati Pokharel Stephane Heymans Leon J de Windt Morten A Høydal Yigal M Pinto Esther E Creemers

J Biol Chem 2010 Aug 21;285(35):27449-56. Epub 2010 Jun 21.

Heart Failure Research Center, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M110.107292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930743PMC
August 2010

The yield of risk stratification for sudden cardiac death in hypertrophic cardiomyopathy myosin-binding protein C gene mutation carriers: focus on predictive screening.

Authors:
Imke Christiaans Erwin Birnie Irene M van Langen Karin Y van Spaendonck-Zwarts J Peter van Tintelen Maarten P van den Berg Douwe E Atsma Apollonia T J M Helderman-van den Enden Yigal M Pinto J F Hermans-van Ast Gouke J Bonsel Arthur A M Wilde

Eur Heart J 2010 Apr 16;31(7):842-8. Epub 2009 Dec 16.

Department of Clinical Genetics, Academic Medical Centre, Amsterdam, The Netherlands.

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https://academic.oup.com/eurheartj/article-lookup/doi/10.109
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http://dx.doi.org/10.1093/eurheartj/ehp539DOI Listing
April 2010

MiR423-5p as a circulating biomarker for heart failure.

Authors:
Anke J Tijsen Esther E Creemers Perry D Moerland Leon J de Windt Allard C van der Wal Wouter E Kok Yigal M Pinto

Circ Res 2010 Apr 25;106(6):1035-9. Epub 2010 Feb 25.

Heart Failure Research Center, Academic Medical Center, Meibergdreef 15, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCRESAHA.110.218297DOI Listing
April 2010

How do hypertrophic cardiomyopathy mutations affect myocardial function in carriers with normal wall thickness? Assessment with cardiovascular magnetic resonance.

Authors:
Tjeerd Germans Iris K Rüssel Marco J W Götte Marieke D Spreeuwenberg Pieter A Doevendans Yigal M Pinto Rob J van der Geest Jolanda van der Velden Arthur A M Wilde Albert C van Rossum

J Cardiovasc Magn Reson 2010 Mar 15;12:13. Epub 2010 Mar 15.

Department of Cardiology, VU University Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1186/1532-429X-12-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842263PMC
March 2010

Syndecan-1 amplifies angiotensin II-induced cardiac fibrosis.

Authors:
Mark W M Schellings Davy Vanhoutte Geert C van Almen Melissa Swinnen Joost J G Leenders Nard Kubben Rick E W van Leeuwen Leo Hofstra Stephane Heymans Yigal M Pinto

Hypertension 2010 Feb 4;55(2):249-56. Epub 2010 Jan 4.

Department of Cardiology, Cardiovascular Research Institute Maastricht, University Hospital Maastricht, Maastricht, The Netherlands.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.137885DOI Listing
February 2010

Absence of thrombospondin-2 causes age-related dilated cardiomyopathy.

Authors:
Melissa Swinnen Davy Vanhoutte Geert C Van Almen Nazha Hamdani Mark W M Schellings Jan D'hooge Jolanda Van der Velden Matthew S Weaver E Helene Sage Paul Bornstein Fons K Verheyen Thierry VandenDriessche Marinee K Chuah Dirk Westermann Walter J Paulus Frans Van de Werf Blanche Schroen Peter Carmeliet Yigal M Pinto Stephane Heymans

Circulation 2009 Oct 5;120(16):1585-97. Epub 2009 Oct 5.

Center for Heart Failure Research, CARIM, Maastricht University, Maastricht, the Netherlands.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.109.863266DOI Listing
October 2009

Avoidance of transient cardiomyopathy in cardiomyocyte-targeted tamoxifen-induced MerCreMer gene deletion models.

Authors:
Norimichi Koitabashi Djahida Bedja Ari L Zaiman Yigal M Pinto Manling Zhang Kathleen L Gabrielson Eiki Takimoto David A Kass

Circ Res 2009 Jul 11;105(1):12-5. Epub 2009 Jun 11.

Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.109.198416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747596PMC
July 2009

Atrial fibrillation and heart failure in cardiology practice: reciprocal impact and combined management from the perspective of atrial fibrillation: results of the Euro Heart Survey on atrial fibrillation.

Authors:
Robby Nieuwlaat Luc W Eurlings John G Cleland Stuart M Cobbe Panos E Vardas Alessandro Capucci José L López-Sendòn Joan G Meeder Yigal M Pinto Harry J G M Crijns

J Am Coll Cardiol 2009 May;53(18):1690-8

Department of Cardiology, University Hospital Maastricht, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.jacc.2009.01.055DOI Listing
May 2009

Renal clearance of B-type natriuretic peptide and amino terminal pro-B-type natriuretic peptide a mechanistic study in hypertensive subjects.

Authors:
Roland R J van Kimmenade James L Januzzi Jaap A Bakker Alphonse J Houben Roger Rennenberg Abraham A Kroon Harry J G M Crijns Marja P van Dieijen-Visser Peter W de Leeuw Yigal M Pinto

J Am Coll Cardiol 2009 Mar;53(10):884-90

Department of Cardiology, University Hospital Maastricht, the Netherlands.

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http://dx.doi.org/10.1016/j.jacc.2008.11.032DOI Listing
March 2009

Cost-effectiveness of genotyping in inherited arrhythmia syndromes: are we getting value for the money?

Authors:
Arthur A M Wilde Yigal M Pinto

Circ Arrhythm Electrophysiol 2009 Feb;2(1):1-3

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http://dx.doi.org/10.1161/CIRCEP.109.849000DOI Listing
February 2009