Yigal Dror

Yigal Dror

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Yigal Dror

Publications by authors named "Yigal Dror"

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PKD1L1-related situs inversus associated with sideroblastic anemia.

Clin Genet 2019 05 21;95(5):629-630. Epub 2019 Feb 21.

Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/cge.13512DOI Listing
May 2019

ERCC6L2-associated inherited bone marrow failure syndrome.

Mol Genet Genomic Med 2018 05 6;6(3):463-468. Epub 2018 Apr 6.

Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/mgg3.388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014454PMC
May 2018

Underlying undiagnosed inherited marrow failure syndromes among children with cancer.

Pediatr Blood Cancer 2017 02 31;64(2):302-305. Epub 2016 Aug 31.

Marrow Failure and Myelodysplasia Program, Division of Haematology and Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.26120DOI Listing
February 2017

Response to treatment with azacitidine in children with advanced myelodysplastic syndrome prior to hematopoietic stem cell transplantation.

Haematologica 2016 12 18;101(12):1508-1515. Epub 2016 Aug 18.

Marrow Failure and Myelodysplasia Program, Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada

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http://dx.doi.org/10.3324/haematol.2016.145821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479623PMC
December 2016

Case 1: A newborn with pancytopenia.

Paediatr Child Health 2016 Jan-Feb;21(1):9-11

Department of Pediatrics, Division of Hematology Oncology, Marrow Failure and Myelodysplasia Program, The Hospital for Sick Children, Toronto, Ontario.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758432PMC
http://dx.doi.org/10.1093/pch/21.1.9DOI Listing
March 2016

Treatment of dyskeratosis congenita-associated pulmonary fibrosis with danazol.

Pediatr Pulmonol 2015 Dec 17;50(12):E48-51. Epub 2015 Jun 17.

Genetics and Genome Biology Program, Research Institute, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/ppul.23235DOI Listing
December 2015

Bone marrow failure and developmental delay caused by mutations in poly(A)-specific ribonuclease (PARN).

J Med Genet 2015 Nov 4;52(11):738-48. Epub 2015 Sep 4.

Genetics and Genome Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/jmedgenet-2015-103292DOI Listing
November 2015

Oral health comparison between children with neutropenia and healthy controls.

Spec Care Dentist 2014 Jan-Feb;34(1):12-8. Epub 2012 Nov 22.

Staff Paediatric Dentist, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/j.1754-4505.2012.00299.xDOI Listing
October 2015

Improving diagnostic precision, care and syndrome definitions using comprehensive next-generation sequencing for the inherited bone marrow failure syndromes.

J Med Genet 2015 Sep 1;52(9):575-84. Epub 2015 Jul 1.

Program in Genetics and Genome Biology, Research Institute, Toronto, Ontario, Canada Marrow Failure and Myelodysplasia Program, Division of Hematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada Faculty of Medicine, Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/jmedgenet-2015-103270DOI Listing
September 2015

Response to comments from Drs. Alter and Rosenberg.

Haematologica 2015 Sep;100(9):e381-2

Marrow Failure and Myelodysplasia Program, Division of Hematology/Oncology, Department of Paediatrics and the Genetics and Genome Biology Program, Research Institute, The Hospital for Sick Children and the University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.3324/haematol.2015.130898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800703PMC
September 2015

Transient erythroblastopenia of childhood is an underdiagnosed and self-limiting disease.

Acta Paediatr 2014 Jul 29;103(7):e288-94. Epub 2014 Apr 29.

Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/apa.12634DOI Listing
July 2014

Molecular characteristics of a pancreatic adenocarcinoma associated with Shwachman-Diamond syndrome.

Pediatr Blood Cancer 2013 May 9;60(5):754-60. Epub 2013 Jan 9.

Cell Biology Program, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1002/pbc.24453
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http://dx.doi.org/10.1002/pbc.24453DOI Listing
May 2013

Gray platelet syndrome: macrothrombocytopenia with deficient α-granules.

Blood 2012 Sep;120(13):2543

Hospital for Sick Children and University of Toronto.

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http://dx.doi.org/10.1182/blood-2012-03-415778DOI Listing
September 2012

Definition of a critical genetic interval related to kidney abnormalities in the Potocki-Lupski syndrome.

Am J Med Genet A 2012 Jul 25;158A(7):1579-88. Epub 2012 May 25.

Division of Clinical and Metabolic Genetics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/ajmg.a.35399DOI Listing
July 2012

The cellular and molecular mechanisms for neutropenia in Barth syndrome.

Eur J Haematol 2012 Mar 4;88(3):195-209. Epub 2011 Dec 4.

Department of Medicine, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1111/j.1600-0609.2011.01725.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445723PMC
March 2012

The ribosome-related protein, SBDS, is critical for normal erythropoiesis.

Blood 2011 Dec 30;118(24):6407-17. Epub 2011 Sep 30.

Cell Biology Program, Research Institute, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/blood-2011-02-335190DOI Listing
December 2011

SBDS-deficiency results in deregulation of reactive oxygen species leading to increased cell death and decreased cell growth.

Pediatr Blood Cancer 2010 Dec;55(6):1138-44

Cell Biology Program, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.22700DOI Listing
December 2010

Proximal radio-ulnar synostosis with bone marrow failure syndrome in an infant without a HOXA11 mutation.

J Pediatr Hematol Oncol 2010 Aug;32(6):479-85

Department of Pediatrics, Riley Hospital for Children, Indiana University School of MedicineCentre, Indianapolis, IN 46202, USA.

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https://insights.ovid.com/crossref?an=00043426-201008000-000
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http://dx.doi.org/10.1097/MPH.0b013e3181e5129dDOI Listing
August 2010

Hepatitis-associated aplastic anemia presenting as a familial bone marrow failure syndrome.

J Pediatr Hematol Oncol 2009 Nov;31(11):884-7

Department of Pediatrics, Division of Pediatric Hematology and Oncology, Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/MPH.0b013e3181b86ec3DOI Listing
November 2009

Aplastic anemia following varicella vaccine.

Pediatr Infect Dis J 2009 Aug;28(8):746-8

Division of Haematology and Oncology, Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1097/INF.0b013e31819b6c1fDOI Listing
August 2009

Bone marrow cells from patients with Shwachman-Diamond syndrome abnormally express genes involved in ribosome biogenesis and RNA processing.

Br J Haematol 2009 Jun 6;145(6):806-15. Epub 2009 May 6.

Cell Biology Program, Research Institute, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/j.1365-2141.2009.07692.xDOI Listing
June 2009

Allogeneic hematopoietic stem cell transplantation of patients with FA and high risk features using fludarabine without radiation.

Pediatr Blood Cancer 2009 May;52(5):683-5

Division of Hematology-Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.21921DOI Listing
May 2009

Complete response to tacrolimus in a child with severe aplastic anemia resistant to cyclosporin A.

Pediatr Blood Cancer 2009 Apr;52(4):525-7

Marrow Failure and Myelodysplasia Program, Division of Haematology and Oncology, Department of Paediatrics, The Hospital for Sick Children, and The University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.21751DOI Listing
April 2009

SBDS-deficiency results in specific hypersensitivity to Fas stimulation and accumulation of Fas at the plasma membrane.

Apoptosis 2009 Jan;14(1):77-89

Cell Biology Program, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

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http://link.springer.com/10.1007/s10495-008-0275-9
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http://dx.doi.org/10.1007/s10495-008-0275-9DOI Listing
January 2009

Ataxia and pancytopenia caused by a mutation in TINF2.

Hum Genet 2008 Dec 1;124(5):507-13. Epub 2008 Nov 1.

Cell Biology Program, Research Institute, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00439-008-0576-7DOI Listing
December 2008

Shwachman-Diamond syndrome: implications for understanding the molecular basis of leukaemia.

Authors:
Yigal Dror

Expert Rev Mol Med 2008 Dec 23;10:e38. Epub 2008 Dec 23.

Division of Haematology/Oncology, Marrow Failure and Myelodysplasia Program,Cell Biology Program, Research Institute The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1017/S1462399408000938DOI Listing
December 2008

Enhanced alternative splicing of the FLVCR1 gene in Diamond Blackfan anemia disrupts FLVCR1 expression and function that are critical for erythropoiesis.

Haematologica 2008 Nov 24;93(11):1617-26. Epub 2008 Sep 24.

The Hospital for Sick Children, Program in Cell Biology, Room 7129 Elm Wing, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.

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http://dx.doi.org/10.3324/haematol.13359DOI Listing
November 2008

An intronic mutation in DKC1 in an infant with Høyeraal-Hreidarsson syndrome.

Am J Med Genet A 2008 Aug;146A(16):2159-61

The McGill Department of Pediatrics, The Montreal Children's Hospital (MUHC), Montreal, Quebec, Canada.

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http://dx.doi.org/10.1002/ajmg.a.32412DOI Listing
August 2008

Clinical and genetic analysis of unclassifiable inherited bone marrow failure syndromes.

Pediatrics 2008 Jul;122(1):e139-48

Marrow Failure and Myelodysplasia Program, Division of Haematology, Research Institute, The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1542/peds.2007-3415DOI Listing
July 2008

SBDS-deficient cells undergo accelerated apoptosis through the Fas-pathway.

Haematologica 2008 Mar 11;93(3):363-71. Epub 2008 Feb 11.

Division of Haematology/Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3324/haematol.11579DOI Listing
March 2008

Outcome of children with aplastic anemia treated with immunosuppressive therapy.

Pediatr Blood Cancer 2008 Jan;50(1):52-7

Cell Biology Program, Research Institute, Division of Haematology and Oncology, Department of Paediatrics, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.21377DOI Listing
January 2008

Neutrophil elastase mutations and risk of leukaemia in severe congenital neutropenia.

Br J Haematol 2008 Jan 20;140(2):210-3. Epub 2007 Nov 20.

Biostatistics Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2007.06897.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143022PMC
January 2008

Remission of aplastic anemia induced by treatment for Graves disease in a pediatric patient.

Pediatr Blood Cancer 2007 Aug;49(2):210-2

Department of Pediatrics, Division of Hematology Oncology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1002/pbc.20640DOI Listing
August 2007

Mutations in the SBDS gene in acquired aplastic anemia.

Blood 2007 Aug 3;110(4):1141-6. Epub 2007 May 3.

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1202, USA.

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http://dx.doi.org/10.1182/blood-2007-03-080044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1939897PMC
August 2007

Leukaemia-related gene expression in bone marrow cells from patients with the preleukaemic disorder Shwachman-Diamond syndrome.

Br J Haematol 2007 Jun;137(6):537-44

Marrow Failure and Myelodysplasia Program, Division of Haematology/Oncology, Department of Paediatrics, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

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http://doi.wiley.com/10.1111/j.1365-2141.2007.06608.x
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http://dx.doi.org/10.1111/j.1365-2141.2007.06608.xDOI Listing
June 2007

Oral health-related quality of life of children with neutropenia.

Spec Care Dentist 2007 Jan-Feb;27(1):6-11

CIHR Group in Matrix Dynamics, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/j.1754-4505.2007.tb00320.xDOI Listing
April 2007

Clinical applications of granulocyte-colony stimulating factor.

Front Biosci 2007 Jan 1;12:1988-2002. Epub 2007 Jan 1.

Division of Haematology and Oncology, Department of Paediatrics, The Hospital for Sick Children , University of Toronto, 555 University Ave. Toronto, Ontario, Canada, M5G 1X8.

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http://dx.doi.org/10.2741/2204DOI Listing
January 2007

Timing of neutrophil tissue repopulation predicts restoration of innate immune protection in a murine bone marrow transplantation model.

Blood 2006 Oct 27;108(8):2821-6. Epub 2006 Jun 27.

Canadian Institutes of Health Research Group in Matrix Dynamics, University of Toronto, Fitzgerald Bldg., 150 College Street, Rm 241, Toronto, Ontario Canada M5S 3E2.

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http://dx.doi.org/10.1182/blood-2006-04-018184DOI Listing
October 2006

Shwachman-Diamond syndrome: an inherited model of aplastic anaemia with accelerated angiogenesis.

Br J Haematol 2006 Jun;133(5):558-61

Marrow Failure and Myelodysplasia Program, Division of Hematology/Oncology, Department of Pediatrics, the Hospital for Sick Children and the University of Toronto, 555 University Avenue, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1111/j.1365-2141.2006.06069.x
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http://dx.doi.org/10.1111/j.1365-2141.2006.06069.xDOI Listing
June 2006

Advances in understanding the genetic basis for bone-marrow failure.

Curr Opin Pediatr 2006 Feb;18(1):15-21

Division of Hematology/Oncology, The Hospital for Sick Children and The University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/01.mop.0000192520.48411.faDOI Listing
February 2006

Mutation analysis of SBDS in pediatric acute myeloblastic leukemia.

Pediatr Blood Cancer 2005 Dec;45(7):920-4

Division of Hematology/Oncology, Marrow Failure and Myelodysplasia Program, Immunity Infection Injury and Repair Programme, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.20416DOI Listing
December 2005

Shwachman-Diamond syndrome.

Authors:
Yigal Dror

Pediatr Blood Cancer 2005 Dec;45(7):892-901

Marrow Failure and Myelodysplasia Program, Division of Haematology and Oncology, Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.20478DOI Listing
December 2005

Reduced intensity hematopoietic stem-cell transplantation across human leukocyte antigen barriers in a patient with congenital amegakaryocytic thrombocytopenia and monosomy 7.

Pediatr Blood Cancer 2005 Aug;45(2):212-6

Marrow Failure and Myelodysplasia Programme, and Blood and Marrow Transplantation Section, Division of Haematology and Oncology, Department of Paediatrics, The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.20332DOI Listing
August 2005

A basic classification and a comprehensive examination of pediatric myeloproliferative syndromes.

J Pediatr Hematol Oncol 2005 Apr;27(4):192-6

Divisions of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1097/01.mph.0000159934.35079.b5DOI Listing
April 2005

Update on childhood neutropenia: molecular and clinical advances.

Hematol Oncol Clin North Am 2004 Dec;18(6):1439-58, x

Division of Hematology/Oncology, The Hospital for Sick Children and The University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8, Canada.

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http://dx.doi.org/10.1016/j.hoc.2004.06.013DOI Listing
December 2004

Transient myelodysplastic syndrome associated with isochromosome 7q abnormality.

Pediatr Hematol Oncol 2003 Oct-Nov;20(7):539-45

Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1080/08880010390232754DOI Listing
June 2004

Purine nucleoside phosphorylase deficiency associated with a dysplastic marrow morphology.

Pediatr Res 2004 Mar 7;55(3):472-7. Epub 2004 Jan 7.

Division of Immunology and Allergy, The Hospital for Sick Children, 555 University Ave., Rm. 7279 Elm Wing, Toronto, Ontario, M5G 1X8, Canada.

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http://dx.doi.org/10.1203/01.PDR.0000111286.23110.F8DOI Listing
March 2004

Sustained cyclosporine-induced erythropoietic response in identical male twins with diamond-blackfan anemia.

J Pediatr Hematol Oncol 2003 Nov;25(11):914-8

Department of Pediatrics, University of Calgary, Alberta Children's Hospital, Canada.

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http://dx.doi.org/10.1097/00043426-200311000-00018DOI Listing
November 2003

Genetic polymorphisms of the beta-2 adrenergic receptor in Israelis with severe asthma compared to non-asthmatic Israelis.

Isr Med Assoc J 2003 Nov;5(11):821-4

Department of Pulmonary Medicine, Meir Hospital, Sapir Medical Center, Kfar Saba, Israel.

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November 2003

Shwachman-Diamond syndrome with late-onset neutropenia and fatal acute myeloid leukaemia without maturation: a case report.

Eur J Haematol 2003 Nov;71(5):393-5

Department of Biological Haematology, University Hospital, Nancy, France.

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http://dx.doi.org/10.1034/j.1600-0609.2003.00146.xDOI Listing
November 2003

Malignant hematological disorders in children with Wolf-Hirschhorn syndrome.

Am J Med Genet A 2003 Jun;119A(2):194-9

Division of Hematology/Oncology The Hospital for Sick Children, and University of Toronto, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1002/ajmg.a.20080
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http://dx.doi.org/10.1002/ajmg.a.20080DOI Listing
June 2003

The role of mitochondrial-mediated apoptosis in a myelodysplastic syndrome secondary to congenital deletion of the short arm of chromosome 4.

Authors:
Yigal Dror

Exp Hematol 2003 Mar;31(3):211-7

The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/s0301-472x(02)01078-0DOI Listing
March 2003

The evolution of juvenile myelomonocytic leukemia in a female patient with paternally inherited neurofibromatosis type 1.

J Pediatr Hematol Oncol 2003 Feb;25(2):145-7

Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/00043426-200302000-00012DOI Listing
February 2003

A practical, comprehensive classification for pediatric myelodysplastic syndromes: the CCC system.

J Pediatr Hematol Oncol 2002 Oct;24(7):596-605

Divison of Hematology/Oncology, Hospital for Sick Children, Department of Pediatrics, University of Toronto, Canada.

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http://dx.doi.org/10.1097/00043426-200210000-00028DOI Listing
October 2002

P53 protein overexpression in Shwachman-Diamond syndrome.

Authors:
Yigal Dror

Arch Pathol Lab Med 2002 Oct;126(10):1157-8; author reply 1158

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http://dx.doi.org/10.1043/1543-2165(2002)126<1157b:PPOISS>2.0.CO;2DOI Listing
October 2002

Shwachman-diamond syndrome.

Br J Haematol 2002 Sep;118(3):701-13

Division of Haematology and Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1046/j.1365-2141.2002.03585.xDOI Listing
September 2002

A practical, comprehensive classification for pediatric myelodysplastic syndromes: the CCC system.

J Pediatr Hematol Oncol 2002 Jun-Jul;24(5):343-52

Division of Hematology/Oncology, Hospital for Sick Children, Department of Pediatrics, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/00043426-200206000-00005DOI Listing
August 2002

Clonal evolution in marrows of patients with Shwachman-Diamond syndrome: a prospective 5-year follow-up study.

Exp Hematol 2002 Jul;30(7):659-69

Department of Paediatrics, Divisions of Hematology and Oncology, The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/s0301-472x(02)00815-9DOI Listing
July 2002

Abnormal telomere shortening in leucocytes of children with Shwachman-Diamond syndrome.

Br J Haematol 2002 Apr;117(1):189-92

Division of Haematology/Oncology, The Hospital for Sick Children, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1046/j.1365-2141.2002.03371.xDOI Listing
April 2002