Publications by authors named "Yifan Hu"

61 Publications

A Case of Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type with Dermatomyositis.

Ann Dermatol 2021 Apr 8;33(2):195-197. Epub 2021 Mar 8.

Department of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5021/ad.2021.33.2.195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082006PMC
April 2021

Combined passivators regulate the heavy metal accumulation and antioxidant response of Brassica chinensis grown in multi-metal contaminated soils.

Environ Sci Pollut Res Int 2021 May 1. Epub 2021 May 1.

College of Resources and Environment, Huazhong Agricultural University, Wuhan, 430070, China.

Passivation of heavy metals is one of the most efficient techniques to remediate soil pollution. However, passivators with single component are usually unsatisfactory in the case of multi-metal contaminated soils. To resolve this problem, a series of combined passivators containing different ratios of Fe-Mn ore, Fe powder, zeolite, bentonite, etc. were designed and used to study their effects on the growth, heavy metal accumulation, and the antioxidant response of Chinese cabbage (Brassica chinensis L.) as well as the soil available forms of heavy metals in a copper refinery's multi-metal (As, Cd, Pb, Cu) contaminated yellow-brown soil and an artificially contaminated (As, Cd, Pb, Cu) calcareous alluvial soil. The results showed that compared with the control, the addition of combined passivators significantly promoted cabbage growth, with the biomass increase up to 1.77 and 3.54 times in yellow-brown soil and calcareous alluvial soil, respectively. The activity of antioxidant enzymes (SOD, CAT, POD) and the content of malondialdehyde (MDA) and glutathione (GSH) decreased, while the chlorophyll content increased significantly, as compared with no passivators. In addition, passivator application decreased As, Cd, Pb, and Cu contents in shoots and roots by 34.8%, 45.6%, 34.9%, and 11.1% and 49.2%, 63.8%, 38.6%, and 46.4% in yellow-brown soil and by 29.8%, 27.3%, 26.8%, and 25.5% and 45.8%, 55.2%, 61.8%, and 5.7% in calcareous alluvial soil, respectively. Besides, the content of soil available heavy metals was reduced by 8.0-17.1% in yellow-brown soil and 3.3-19.1% in calcareous alluvial soil after the application of passivators. The results indicated that the combined passivators formulated in this experiment could efficiently reduce the content of the multi-metals in cabbage and relieve the oxidant stress and could be used as a way to remediate multi-metal polluted soils.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11356-021-14193-xDOI Listing
May 2021

Adjust Neuronal Reactions to Pulses of High-Frequency Stimulation with Designed Inter-Pulse-Intervals in Rat Hippocampus In Vivo.

Brain Sci 2021 Apr 16;11(4). Epub 2021 Apr 16.

Key Laboratory of Biomedical Engineering of Education Ministry, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310007, China.

Sequences of electrical pulses have been applied in the brain to treat certain disorders. In recent years, altering inter-pulse-interval (IPI) regularly or irregularly in real time has emerged as a promising way to modulate the stimulation effects. However, algorithms to design IPI sequences are lacking. This study proposed a novel strategy to design pulse sequences with varying IPI based on immediate neuronal reactions. Firstly, to establish the correlationship between the neuronal reactions with varying IPIs, high-frequency stimulations with varying IPI in the range of 5-10 ms were applied at the alveus of the hippocampal CA1 region of anesthetized rats in vivo. Antidromically-evoked population spikes (APS) following each IPI were recorded and used as a biomarker to evaluate neuronal reactions to each pulse. A linear mapping model was established to estimate the varied APS amplitudes by the two preceding IPIs. Secondly, the mapping model was used to derive an algorithm for designing an IPI sequence that would be applied for generating a desired neuronal reaction pre-defined by a particular APS distribution. Finally, examples of stimulations with different IPI sequences designed by the algorithm were verified by rat experiments. The results showed that the designed IPI sequences were able to reproduce the desired APS responses of different distributions in the hippocampal stimulations. The novel algorithm of IPI design provides a potential way to obtain various stimulation effects for brain stimulation therapies.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/brainsci11040509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073706PMC
April 2021

Direct Synthesis of -Halogenated Arylphosphonates via a Three-Component Reaction Involving Arynes.

J Org Chem 2021 May 21;86(9):7010-7018. Epub 2021 Apr 21.

School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, P. R. China.

A three-component reaction involving arynes, trialkyl phosphites, and halides has been achieved under mild reaction conditions. This transformation provides a direct synthetic approach to -halogenated arylphosphonates, which could be rapidly converted to diversely -functionalized arylphosphorus compounds.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.joc.1c00550DOI Listing
May 2021

Simultaneous Kinetics of Selenite Oxidation and Sorption on δ-MnO in Stirred-Flow Reactors.

Int J Environ Res Public Health 2021 03 12;18(6). Epub 2021 Mar 12.

College of Resources and Environment, Huazhong Agricultural University, Wuhan 430070, China.

Selenium (Se) is an essential and crucial micronutrient for humans and animals, but excessive Se brings negativity and toxicity. The adsorption and oxidation of Se(IV) on Mn-oxide surfaces are important processes for understanding the geochemical fate of Se and developing engineered remediation strategies. In this study, the characterization of simultaneous adsorption, oxidation, and desorption of Se(IV) on δ-MnO mineral was carried out using stirred-flow reactors. About 9.5% to 25.3% of Se(IV) was oxidized to Se(VI) in the stirred-flow system in a continuous and slow process, with the kinetic rate constant k of 0.032 h, which was significantly higher than the apparent rate constant of 0.0014 h obtained by the quasi-level kinetic fit of the batch method. The oxidation reaction was driven by proton concentration, and its rate also depended on the Se(IV) influent concentration, flow rate, and δ-MnO dosage. During the reaction of Se(IV) and δ-MnO, Mn(II) was produced and adsorbed strongly on Mn oxide surfaces, which was evidenced by the total reflectance Fourier transform infrared (ATR-FTIR) results. The X-ray photoelectron spectroscopy (XPS) data indicated that the reaction of Se(VI) on δ-MnO produced Mn(III) as the main product. These results contribute to a deeper understanding of the interface chemical process of Se(IV) with δ-MnO in the environment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph18062902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998768PMC
March 2021

Cultivating Affective Resilience: Proof-of-Principle Evidence of Translational Benefits From a Novel Cognitive-Emotional Training Intervention.

Front Psychol 2021 9;12:585536. Epub 2021 Mar 9.

Department of Psychology, University of Illinois at Urbana-Champaign, Champaign, IL, United States.

Available evidence highlights the importance of emotion regulation (ER) in psychological well-being. However, translation of the beneficial effects of ER from laboratory to real-life remains scarce. Here, we present proof-of-principle evidence from a novel cognitive-emotional training intervention targeting the development of ER skills aimed at increasing resilience against emotional distress. This pilot intervention involved training military veterans over 5-8 weeks in applying two effective ER strategies [Focused Attention (FA) and Cognitive Reappraisal (CR)] to scenarios presenting emotional conflicts (constructed with both and cues). Training was preceded and followed by neuropsychological, personality, and clinical assessments, and resting-state functional MRI data were also collected from a subsample of the participants. Results show enhanced executive function and psychological well-being following training, reflected in increased working memory (WM), post-traumatic growth (PTG), and general self-efficacy (GSE). Brain imaging results showed evidence of diminished bottom-up influences from emotional and perceptual brain regions, along with evidence of normalized functional connectivity in the large-scale functional networks following training. The latter was reflected in increased connectivity among cognitive and emotion control regions and across regions of self-referential and control networks. Overall, our results provide proof-of-concept evidence that resilience and well-being can be learned through ER training, and that training-related improvements manifested in both behavioral change and neuroplasticity can translate into real-life benefits.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpsyg.2021.585536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985085PMC
March 2021

MicroRNA-191-5p ameliorates amyloid-β -mediated retinal pigment epithelium cell injury by suppressing the NLRP3 inflammasome pathway.

FASEB J 2021 Apr;35(4):e21184

Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.

Amyloid β (Aβ) is a crucial component of drusen, the hallmark of the early stage of age-related macular degeneration (AMD), and can cause retinal pigment epithelium (RPE) cell damage through activation of the inflammatory response. MicroRNAs play a critical role in inflammation. However, the mechanism underlying the effect of microRNAs on the NLRP3 inflammasome induced by Aβ remains poorly understood. In the present study, we demonstrated that Aβ -mediated RPE damage by inducing a decrease in endogenous miR-191-5p expression. This led to the upregulation of its target gene, C/EBPβ. C/EBPβ acts as a transcription factor for NLRP3, promotes its transcription, and upregulates the downstream inflammatory factors Caspase-1 and IL-1β. Correspondingly, overexpression of miR-191-5p alleviated RPE cell injury by suppressing inflammation. The present study elucidates a novel transcriptional regulatory mechanism of the NLRP3 inflammasome. Our findings suggest an anti-inflammatory effect of miR-191-5p in Aβ -induced RPE impairment, shedding light on novel preventive or therapeutic approaches for AMD-associated RPE impairment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.202000645RRDOI Listing
April 2021

Study on the Anti-Tumor Mechanism and Target of Triptolide based on Network Pharmacology and Molecular Docking.

Recent Pat Anticancer Drug Discov 2021 Feb 11. Epub 2021 Feb 11.

Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000. China.

Background: According to the special physiological and pharmacological activities of natural compounds, many drugs with special therapeutic effects have been developed. The triptolide (TP) is a kind of natural anti-tumor drug with a world patent, but its target and mechanism are yet not known.

Objective: The study aims to explore and predict the target and mechanism of TP on non-small cell lung cancer (NSCLC), pancreatic cancer (PC) and colorectal cancer (CC) through network pharmacology technology.

Methods: We screened the core targets of TP with NSCLC, PC and CC, respectively, and carried out network analysis, enrichment analysis and ligand-receptor docking to clarify its potential pharmacological mechanism.

Results: By screening the core genes between TP with NSCLC, PC and CC, respectively, it was found that PTGS2 was the common target gene in the three cancers. NSCLC, CCL2, IL6, HMOX1 and COL1A1 are the specific target genes, while MMP2, JUN, and CXCL8 are the specific target genes in PC. In CC, the specific target genes includeERBB2, VEGFA, STAT1 andMAPK8. In enrichment analysis, it was found that the NF- κB, toll-like receptors and IL-17 signaling pathway were mainly involved in TP for these cancers. The binding energy of TP to the core target is less than that of cyclophosphamide.

Conclusions: This study preliminarily revealed that TP may prevent and treat cancers\ through multiple targets and pathways. The possible mechanisms of TP include regulating immune and inflammatory responses, promoting apoptosis and inhibiting tumor development. It shows that TP may have a potential in treating kinds of tumors.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2174/1574892816666210211143059DOI Listing
February 2021

Social Collective Attack Model and Procedures for Large-Scale Cyber-Physical Systems.

Sensors (Basel) 2021 Feb 2;21(3). Epub 2021 Feb 2.

Department of Electronic Information and Electrical Engineering, Changsha University, Changsha 410022, China.

A large-scale Cyber-Physical System (CPS) such as a smart grid usually provides service to a vast number of users as a public utility. Security is one of the most vital aspects in such critical infrastructures. The existing CPS security usually considers the attack from the information domain to the physical domain, such as injecting false data to damage sensing. Social Collective Attack on CPS (SCAC) is proposed as a new kind of attack that intrudes into the social domain and manipulates the collective behavior of social users to disrupt the physical subsystem. To provide a systematic description framework for such threats, we extend MITRE ATT&CK, the most used cyber adversary behavior modeling framework, to cover social, cyber, and physical domains. We discuss how the disinformation may be constructed and eventually leads to physical system malfunction through the social-cyber-physical interfaces, and we analyze how the adversaries launch disinformation attacks to better manipulate collective behavior. Finally, simulation analysis of SCAC in a smart grid is provided to demonstrate the possibility of such an attack.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/s21030991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867278PMC
February 2021

Three-Dimensional Model of the Moon with Semantic Information of Craters Based on Chang'e Data.

Sensors (Basel) 2021 Feb 1;21(3). Epub 2021 Feb 1.

School of Artificial Intelligence, University of Chinese Academy of Sciences, No. 19 Yuquan Road, Shijingshan District, Beijing 100049, China.

China's Chang'e lunar exploration project obtains digital orthophoto image (DOM) and digital elevation model (DEM) data covering the whole Moon, which are critical to lunar research. The DOM data have three resolutions (i.e., 7, 20 and 50 m), while the DEM has two resolutions (i.e., 20 and 50 m). Analysis and research on these image data effectively help humans to understand the Moon. In addition, impact craters are considered the most basic feature of the Moon's surface. Statistics regarding the size and distribution of impact craters are essential for lunar geology. In existing works, however, the lunar surface has been reconstructed less accurately, and there is insufficient semantic information regarding the craters. In order to build a three-dimensional (3D) model of the Moon with crater information using Chang'e data in the Chang'e reference frame, we propose a four-step framework. First, software is implemented to annotate the lunar impact craters from Chang'e data by complying with our existing study on an auxiliary annotation method and open-source software LabelMe. Second, auxiliary annotation software is adopted to annotate six segments in the Chang'e data for an overall 25,250 impact crater targets. The existing but inaccurate craters are combined with our labeled data to generate a larger dataset of craters. This data set is analyzed and compared with the common detection data. Third, deep learning detection methods are employed to detect impact craters. To address the problem attributed to the resolution of Chang'e data being too high, a quadtree decomposition is conducted. Lastly, a geographic information system is used to map the DEM data to 3D space and annotate the semantic information of the impact craters. In brief, a 3D model of the Moon with crater information is implemented based on Chang'e data in the Chang'e reference frame, which is of high significance.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/s21030959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867113PMC
February 2021

Starch physicochemical properties of double recessive sweet-waxy maize.

Int J Biol Macromol 2021 Mar 19;173:219-224. Epub 2021 Jan 19.

Jiangsu Key Laboratory of Crop Genetics and Physiology, Jiangsu Key Laboratory of Crop Cultivation and Physiology, Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops, Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou 225009, China. Electronic address:

Sweet-waxy is a new type of maize with waxy and sugary double recessive genes. This study aims to clarify starch structural and functional properties of this maize type. Grains with sweet-waxy and waxy phenotypes were separated from an ear using the two sweet-waxy maize hybrids of ATN and NKY as materials. Compared with waxy maize starch, the sweet-waxy maize starch mainly comprises small-sized round granules despite the typical waxy character of both starches. Mw, Mn, and relative crystallinity of sweet-waxy starch were higher than those of waxy starch in both hybrids. The average chain length of waxy starch was higher in ATN but lower in NKY compared with that of sweet-waxy starch. However, polydispersity (Mw/Mn) and F1 fraction were high in sweet-waxy and waxy starches in ATN and NKY, respectively. Breakdown viscosity, gelatinization enthalpy and temperatures of both hybrids were low in sweet-waxy starch. Peak viscosity was higher in waxy starch in NKY and similar between sweet-waxy and waxy starches in ATN. Retrogradation percentage was high and low for sweet-waxy starches in ATN and NKY, respectively.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2021.01.116DOI Listing
March 2021

Changes in the thermal stability and structure of myofibrillar protein from quick-frozen pork patties with different fat addition under freeze-thaw cycles.

Meat Sci 2021 May 31;175:108420. Epub 2020 Dec 31.

College of Food Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, China. Electronic address:

Changes in thermal stability and structure of myofibrillar protein from pork patties with different fat addition (0%, 5%, 10%, 15% and 20%) under freeze-thaw (F-T) cycles were discussed. The results showed that the total sulfhydryl, reactive sulfhydryl, free amino group, α-helix and β-sheet contents, fluorescence intensity (FI), and protein thermal stability (T, ∆H) of samples with the same fat content were significantly decreased, while the β-turn and random-coil content and the maximum fluorescence emission wavelength (λ) were significantly increased with increasing F-T cycles (P < 0.05). These changes in samples with 20% fat at the 5th F-T cycle were obvious and were verified by the decreases in ∆H (26.1%), reactive sulfhydryl (16.1%), and FI (16.8%) compared with the patties without fat. Therefore, repeated F-T cycles could decline the thermal stability of protein, destroy the protein structure of patty, and the changes were positively correlated with fat content of patty.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.meatsci.2020.108420DOI Listing
May 2021

Regional-level risk factors for severe hand-foot-and-mouth disease: an ecological study from mainland China.

Environ Health Prev Med 2021 Jan 8;26(1). Epub 2021 Jan 8.

Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China.

Background: Severe hand-foot-and-mouth disease (HFMD) is a life-threatening contagious disease among young children and infants. Although enterovirus A71 has been well acknowledged to be the dominant cause of severe HFMD, there still remain other unidentified risk factors for severe HFMD. Previous studies mainly focused on identifying the individual-level risk factors from a clinical perspective, while rare studies aimed to clarify the association between regional-level risk factors and severe HFMD, which may be more important from a public health perspective.

Methods: We retrieved the clinical HFMD counts between 2008 and 2014 from the Chinese Center for Disease Control and Prevention, which were used to calculated the case-severity rate in 143 prefectural-level cities in mainland China. For each of those 143 cities, we further obtained city-specific characteristics from the China City Statistical Yearbook (social and economic variables) and the national meteorological monitoring system (meteorological variables). A Poisson regression model was then used to estimate the associations between city-specific characteristics (reduced by the principal component analysis to avoid multicollinearity) and the case-severity rate of HFMD. The above analysis was further stratified by age and gender to examine potential modifying effects and vulnerable sub-populations.

Results: We found that the case-severity rate of HFMD varied dramatically between cities, ranging from 0 to 8.09%. Cities with high case-severity rates were mainly clustered in Central China. By relating the case-severity rate to city-specific characteristics, we found that both the principal component characterized by a high level of social and economic development (RR = 0.823, 95%CI 0.739, 0.916) and another that characterized by warm and humid climate (RR = 0.771, 95%CI 0.619, 0.960) were negatively associated with the case-severity rate of HFMD. These estimations were consistent across age and gender sub-populations.

Conclusion: Except for the type of infected pathogen, the case-severity rate of HFMD was closely related to city development and meteorological factor. These findings suggest that social and environmental factors may also play an important role in the progress of severe HFMD.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12199-020-00927-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792012PMC
January 2021

Religiosity and Resilience: Cognitive Reappraisal and Coping Self-Efficacy Mediate the Link between Religious Coping and Well-Being.

J Relig Health 2021 Jan 7. Epub 2021 Jan 7.

Psychology Department, University of Illinois at Urbana-Champaign, Urbana, IL, 61820, USA.

Qualitative evidence points to the engagement of religious coping strategies when facing adversity, and evidence also highlights the effectiveness of cognitive reappraisal in reducing the impact of distressing emotions on well-being. It has been suggested that religious practices could facilitate the use of reappraisal, by promoting reframing of negative cognitions to alter emotional states. However, the link between religiosity and reappraisal in influencing resilience against symptoms of distress is not known. The current study (N = 203) examined connections among these aspects, using self-reported measures of religious coping, habitual use of specific coping strategies (positive reappraisal) and perceived confidence in using coping strategies, as well as questionnaires assessing symptoms of distress (anxiety and depression). Results point to a mediating role of reappraisal and coping self-efficacy as part of mechanisms that provide a protecting role of religious coping against emotional distress. These results provide novel scientific evidence further validating millennia-old traditional coping practices and shed light on psychological factors influencing adaptive behaviors that promote increased resilience, reduce symptoms of distress, and maintain emotional well-being. These findings inform general counseling practices and counseling of religious clients alike.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10943-020-01160-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790337PMC
January 2021

ROS production and mitochondrial dysfunction driven by PU.1-regulated NOX4-p22 activation in Aβ-induced retinal pigment epithelial cell injury.

Theranostics 2020 19;10(25):11637-11655. Epub 2020 Sep 19.

Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Amyloid β (Aβ) deposition, an essential pathological process in age-related macular degeneration (AMD), causes retinal pigment epithelium (RPE) degeneration driven mostly by oxidative stress. However, despite intense investigations, the extent to which overoxidation contributes to Aβ-mediated RPE damage and its potential mechanism has not been fully elucidated. We performed tandem mass-tagged (TMT) mass spectrometry (MS) and bioinformatic analysis of the RPE-choroid complex in an Aβ-induced mouse model of retinal degeneration to obtain a comprehensive proteomic profile. Key regulators in this model were confirmed by reactive oxygen species (ROS) detection, mitochondrial ROS assay, oxygen consumption rate (OCR) measurement, gene knockout experiment, chromatin immunoprecipitation (ChIP), and luciferase assay. A total of 4243 proteins were identified, 1069 of which were significantly affected by Aβ and found to be enriched in oxidation-related pathways by bioinformatic analysis. Moreover, NADPH oxidases were identified as hub proteins in Aβ-mediated oxidative stress, as evidenced by mitochondrial dysfunction and reactive oxygen species overproduction. By motif and binding site analyses, we found that the transcription factor PU.1/Spi1 acted as a master regulator of the activation of NADPH oxidases, especially the NOX4-p22 complex. Also, PU.1 silencing impeded RPE oxidative stress and mitochondrial dysfunction and rescued the retinal structure and function. Our study suggests that PU.1 is a novel therapeutic target for AMD, and the regulation of PU.1 expression represents a potentially novel approach against excessive oxidative stress in Aβ-driven RPE injury.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.7150/thno.48064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546003PMC
September 2020

Short-term effects of rainfall on childhood hand, foot and mouth disease and related spatial heterogeneity: evidence from 143 cities in mainland China.

BMC Public Health 2020 Oct 9;20(1):1528. Epub 2020 Oct 9.

Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, No. 16, Section 3, South Renmin Road, Chengdu, Sichuan, 610041, PR China.

Background: Numerous studies have demonstrated the potential association between rainfall and hand, foot and mouth disease (HFMD), but the results are inconsistent. This study aimed to quantify the relationship between rainfall and HFMD based on a multicity study and explore the potential sources of spatial heterogeneity.

Methods: We retrieved the daily counts of childhood HFMD and the meteorological variables of the 143 cities in mainland China between 2009 and 2014. A common time series regression model was applied to quantify the association between rainfall and HFMD for each of the 143 cities. Then, we adopted the meta-regression model to pool the city-specific estimates and explore the sources of heterogeneity by incorporating city-specific characteristics.

Results: The overall pooled estimation suggested a nonlinear exposure-response relationship between rainfall and HFMD. Once rainfall exceeded 15 mm, the HFMD risk stopped increasing linearly and began to plateau with the excessive risk ratio (ERR) peaking at 21 mm of rainfall (ERR = 3.46, 95% CI: 2.05, 4.88). We also found significant heterogeneity in the rainfall-HFMD relationships (I = 52.75%, P < 0.001). By incorporating the city-specific characteristics into the meta-regression model, temperature and student density can explain a substantial proportion of spatial heterogeneity with I statistics that decreased by 5.29 and 6.80% at most, respectively.

Conclusions: Our findings verified the nonlinear association between rainfall and HFMD. The rainfall-HFMD relationship also varies depending on locations. Therefore, the estimation of the rain-HFMD relationship of one location should not be generalized to another location.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12889-020-09633-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545871PMC
October 2020

Engineering Hierarchical CoO Nanospheres Wrapped by Graphene via Controllable Sulfur Doping for Superior Li Ion Storage.

Small 2020 Oct 29;16(42):e2003643. Epub 2020 Sep 29.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 585 He Shuo Road, Shanghai, 201899, China.

The inferior conductivity and large volume expansion impair the widespread applications of metal oxide-based anode materials for lithium-ion batteries. To address these issues, herein an efficient strategy of structural engineering is proposed to improve lithium storage performance of hierarchical CoO nanospheres wrapped by graphene via controllable S-doping (CoOS   @ G). S-doping promotes the Li diffusion kinetics of CoO by expanding the interplanar spacing of CoO, lowering the activation energy, and improving the pseudocapacitance contribution. Meanwhile, the electronic structure of CoO is adjusted by S-doping as confirmed by density functional theory calculations, thus enhancing the conductivity. Finite element analysis reveals that the produced Li S during lithiation improves the structural stability of the S-doped electrode, which is further confirmed by experimental observation. As expected, CoOS   @ G exhibits excellent lithium storage performance with an initial discharge capacity of 1974 mAh g at 100 mA g , and high discharge capacity of 1573 mAh g after 400 cycles at 500 mA g . It is believed that the insights into the structural doping enlighten research to explore other metal oxides for fast and stable Li ion storage.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/smll.202003643DOI Listing
October 2020

Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM.

Sci Adv 2020 Jul 29;6(31):eabb2964. Epub 2020 Jul 29.

Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.

Mutations in ryanodine receptors (RyRs), intracellular Ca channels, are associated with deadly disorders. Despite abundant functional studies, the molecular mechanism of RyR malfunction remains elusive. We studied two single-point mutations at an equivalent site in the skeletal (RyR1 R164C) and cardiac (RyR2 R176Q) isoforms using ryanodine binding, Ca imaging, and cryo-electron microscopy (cryo-EM) of the full-length protein. Loss of the positive charge had greater effect on the skeletal isoform, mediated via distortion of a salt bridge network, a molecular latch inducing rotation of a cytoplasmic domain, and partial progression to open-state traits of the large cytoplasmic assembly accompanied by alteration of the Ca binding site, which concur with the major "hyperactive" feature of the mutated channel. Our cryo-EM studies demonstrated the allosteric effect of a mutation situated ~85 Å away from the pore and identified an isoform-specific structural effect.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1126/sciadv.abb2964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439390PMC
July 2020

TRIM31 inhibits NLRP3 inflammasome and pyroptosis of retinal pigment epithelial cells through ubiquitination of NLRP3.

Cell Biol Int 2020 Nov 5;44(11):2213-2219. Epub 2020 Aug 5.

Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China.

NOD-like receptor protein 3 (NLRP3) is associated with age-related macular degeneration (AMD). Retinal pigment epithelial (RPE) cells serve as the immune defense of macula, and their dysfunction causes clinically relevant changes in AMD. In the present study, oxidized low-density lipoprotein (ox-LDL) activated the NLRP3 inflammasome in human RPE cell line ARPE-19. Our data showed that the expression of NLRP3, interleukin-1β (IL-1β), and caspase-1 and the release of IL-1β in ARPE-19 cells were substantially increased by ox-LDL, whereas the addition of NLRP3 inhibitor INF39 dose-dependently reversed the effect of ox-LDL. Overexpression of tripartite motif-containing protein 31 (TRIM31) also suppressed the effect of ox-LDL in ARPE-19 cells. TRIM31 knockdown had similar effects with ox-LDL but INF39 could block the effect of TRIM31 knockdown. Moreover, TRIM31 could interact with NLRP3 in ARPE-19 cells. Overexpression of TRIM31 increased NLRP3 ubiquitination. In conclusion, the results propose that TRIM31 could enhance NLRP3 ubiquitination, therefore inhibiting NLRP3 inflammasome and pyroptosis in human RPE cells.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbin.11429DOI Listing
November 2020

Suppression of sirtuin 1 alleviates airway inflammation through mTOR‑mediated autophagy.

Mol Med Rep 2020 Sep 13;22(3):2219-2226. Epub 2020 Jul 13.

Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China.

Sirtuin 1 (SIRT1) is involved in the pathogenesis of allergic asthma. This study aimed to investigate whether EX‑527, a specific SIRT1 inhibitor, exerted suppressive effects on allergic airway inflammation in mice submitted to ovalbumin (OVA) inhalation. In addition, this study assessed whether such a protective role was mediated by autophagy suppression though mammalian target of rapamycin (mTOR) activation. Female C57BL/6 mice were sensitized to OVA and EX‑527 (10 mg/kg) was administered prior to OVA challenge. The study found that EX‑527 reversed OVA‑induced airway inflammation, and reduced OVA‑induced increases in inflammatory cytokine expression, and total cell and eosinophil counts in bronchoalveolar lavage fluid. In addition, EX‑527 enhanced mTOR activation, thereby suppressing autophagy in allergic mice. To assess whether EX‑527 inhibited airway inflammation in asthma through the mTOR‑mediated autophagy pathway, rapamycin was administered to mice treated with EX‑527 after OVA sensitization. All effects induced by EX‑527, including increased phosphorylated‑mTOR and decreased autophagy, were abrogated by rapamycin treatment. Taken together, the present findings indicated that EX‑527 may inhibit allergic airway inflammation by suppressing autophagy, an effect mediated by mTOR activation in allergic mice.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3892/mmr.2020.11338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411491PMC
September 2020

Functional evaluation with microperimetry in large idiopathic macular holes treated by a free internal limiting membrane flap tamponade technique.

BMC Ophthalmol 2020 Jul 23;20(1):302. Epub 2020 Jul 23.

Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, No.100 Hai Ning Road, Shanghai, 200080, China.

Background: Free internal limiting membrane (ILM) flap tamponade technique is an alternative choice for treating large idiopathic macular holes (IMHs). However, the functional recovery related to this surgical approach is not well-characterized. This study aimed to evaluate morphological and microperimetric outcomes 6 months after free ILM flap tamponade technique for large IMHs.

Methods: Twenty-two patients (22 eyes) with large IMHs (minimal diameter > 400 μm) were retrospectively enrolled in this study. All patients underwent 23-gauge pars plana vitrectomy with ILM peeling and free ILM flap tamponade procedures. Snellen best-corrected visual acuity (BCVA), optical coherence tomography (OCT), and MP-1 microperimetry were measured at baseline and 6 months after surgery. Associations of postoperative BCVA with retinal sensitivity were detected.

Results: Macular hole closure was achieved in 21 eyes (95.5%). Dislodgement of free ILM flap was found in non-closed eye. Mean logMAR BCVA improved from 1.10 ± 0.33 at baseline to 0.67 ± 0.32 at 6 months postoperatively (P < 0.001). The mean overall macular sensitivity and foveal fixation stability increased respectively from 8.58 ± 3.05 dB and 65.64 ± 17.28% before surgery to 11.55 ± 2.72 dB and 78.59 ± 13.00% at 6 months after surgery (P < 0.001). The mean change in foveal sensitivity (within 2°) was significantly greater than the change achieved for peri-foveal sensitivity (2° to 10°) by 1.50 ± 2.62 dB (P = 0.014). Linear regression analysis showed that postoperative logMAR BCVA was significantly associated with duration of symptom (B = 0.063, P = 0.001), preoperative logMAR BCVA (B = 0.770, P = 0.000), preoperative peri-foveal (B = - 0.065, P = 0.000) and foveal sensitivity (B = - 0.129, P = 0.000). Moreover, multiple regression model revealed that preoperative foveal sensitivity was independently associated with postoperative logMAR BCVA (B = - 0.430, P = 0.040).

Conclusions: Vitrectomy combined with ILM peeling and free ILM flap tamponade technique results in effective morphological and functional recovery for large IMHs. Preoperative foveal sensitivity might be a prognostic indicator for postoperative BCVA.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12886-020-01573-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379782PMC
July 2020

Interface Engineering with Ultralow Ruthenium Loading for Efficient Water Splitting.

ACS Appl Mater Interfaces 2020 Aug 3;12(32):36177-36185. Epub 2020 Aug 3.

State Key Laboratory of High-Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 585 Heshuo Road, Shanghai 201899, P. R. China.

Developing high-performance and cost-effective bifunctional electrocatalysts for water splitting is the key to large-scale hydrogen production. How to achieve higher performance with a lower amount of noble metal is still a major challenge. Herein, using a facile wet-chemistry strategy, we report the ultralow amount loading of ruthenium (Ru) on porous nickel foam (NF) as a highly efficient bifunctional electrocatalyst for water splitting. Theoretical simulations reveal that the coupling effect of Ru and Ni can significantly reduce the d-band center of the composite. The Ru-modified NF exhibits a very high level of HER activity with only 0.3 wt% of Ru, far surpassing commercial Pt/C. It only requires an extremely low overpotential (η) of 10 mV to achieve a current density of 10 mA cm in alkaline solution and a quite low Tafel slope of 34 mV dec. This catalyst also shows remarkable performance for overall water splitting with a low voltage of 1.56 V at 10 mA cm. These findings indicate the potential of this material in water-alkali electrolyzers, providing a new approach for fabrication of low-cost advanced electrocatalysts.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.0c09593DOI Listing
August 2020

Rubik's Cube+: A self-supervised feature learning framework for 3D medical image analysis.

Med Image Anal 2020 08 6;64:101746. Epub 2020 Jun 6.

Tencent Jarvis Lab, Shenzhen, China.

Due to the development of deep learning, an increasing number of research works have been proposed to establish automated analysis systems for 3D volumetric medical data to improve the quality of patient care. However, it is challenging to obtain a large number of annotated 3D medical data needed to train a neural network well, as such manual annotation by physicians is time consuming and laborious. Self-supervised learning is one of the potential solutions to mitigate the strong requirement of data annotation by deeply exploiting raw data information. In this paper, we propose a novel self-supervised learning framework for volumetric medical data. Specifically, we propose a pretext task, i.e., Rubik's cube+, to pre-train 3D neural networks. The pretext task involves three operations, namely cube ordering, cube rotating and cube masking, forcing networks to learn translation and rotation invariant features from the original 3D medical data, and tolerate the noise of the data at the same time. Compared to the strategy of training from scratch, fine-tuning from the Rubik's cube+ pre-trained weights can remarkablely boost the accuracy of 3D neural networks on various tasks, such as cerebral hemorrhage classification and brain tumor segmentation, without the use of extra data.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.media.2020.101746DOI Listing
August 2020

UrbanMotion: Visual Analysis of Metropolitan-Scale Sparse Trajectories.

IEEE Trans Vis Comput Graph 2020 May 4;PP. Epub 2020 May 4.

Visualizing massive scale human movement in cities plays an important role in solving many of the problems that modern cities face (e.g., traffic optimization, business site configuration). In this work, we study a big mobile location dataset that covers millions of city residents, but is temporally sparse on the trajectory of individual user. Mapping sparse trajectories to illustrate population movement poses several challenges from both analysis and visualization perspectives. In the literature, there are a few techniques designed for sparse trajectory visualization; yet they do not consider trajectories collected from mobile apps that possess long-tailed sparsity with record intervals as long as hours. This work introduces UrbanMotion, a visual analytics system that extends the original wind map design by supporting map-matched local movements, multi-directional population flows, and population distributions. Effective methods are proposed to extract and aggregate population movements from dense parts of the trajectories leveraging their long-tailed sparsity. Both characteristic and anomalous patterns are discovered and visualized. We conducted three case studies, one comparative experiment, and collected expert feedback in the application domains of commuting analysis, event detection, and business site configuration. The result demonstrates significance and effectiveness of our system in completing key analytics tasks for urban users.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1109/TVCG.2020.2992200DOI Listing
May 2020

High-throughput transcriptome and pathogenesis analysis of clinical psoriasis.

J Dermatol Sci 2020 May 10;98(2):109-118. Epub 2020 Apr 10.

Department of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China; Institute of Psoriasis, Tongji University School of Medicine, Shanghai, China. Electronic address:

Background: Previous psoriasis studies have mostly focused on skin-related immunology, but the exact mechanisms remain elusive. Clinical evidence, such as higher morbidity among obese individuals and emotional factors, indicate that psoriasis is a complex systemic disease. High-throughput transcriptome analysis provides an effective method to comprehensively assess the disease.

Objective: The present study is aiming to understand transcriptome changes of clinical psoriasis skins and comprehensively assess the diseases using pathways analysis.

Methods: We performed transcriptome sequence of clinical psoriatic samples. Biological pathway analyses were conducted using differentially expressed RNAs, as well as identified competing endogenous RNAs (ceRNAs). qRT-PCR and histological immunofluorescence staining was conducted to verify the differentially expressed RNAs (DE_RNAs) and the three important enriched biological pathways.

Results: Numerous DE_RNAs were identified between psoriasis patients and healthy people. Functional analysis indicated PPAR-fatty acids metabolism pathways, neural-hormone regulations, circadian entrainment were the three mostly appeared pathways. For PPAR-fatty acids metabolism pathways, the expression of seven randomly selected genes, including ACSBG1, ACOT2), CYP27A1, ELOVL3, FABP7, FADS2 and PPARG were all significantly decreased in psoriasis lesions. For neural-hormone regulation pathways, the expression of CFL1, EPHA2, HRAS were all significantly upregulated in psoriasis lesions. While the expression of four randomly selected genes from circadian entrainment pathways, including CRY2, PER3, NR1D1 and RORC were all significantly downregulated. Histological immunofluorescence staining of FADS2, EPHA2 and CRY2 were consistent with their genes' expressions.

Conclusion: Our results revealed transcriptome changes of psoriasis, and indicated three important pathways involved in psoriasis, including PPAR-fatty acids metabolism pathways, neural-hormone regulations, circadian entrainment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdermsci.2020.03.006DOI Listing
May 2020

[A spike denoising method combined principal component analysis with wavelet and ensemble empirical mode decomposition].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2020 Apr;37(2):271-279

School of Electrical Engineering, Zhengzhou University, Zhengzhou 450001, P.R.China;Henan Key Laboratory of Brain Science and Brain-Computer Interface Technology, Zhengzhou University, Zhengzhou 450001, P.R.China.

Spike recorded by multi-channel microelectrode array is very weak and susceptible to interference, whose noisy characteristic affects the accuracy of spike detection. Aiming at the independent white noise, correlation noise and colored noise in the process of spike detection, combining principal component analysis (PCA), wavelet analysis and adaptive time-frequency analysis, a new denoising method (PCWE) that combines PCA-wavelet (PCAW) and ensemble empirical mode decomposition is proposed. Firstly, the principal component was extracted and removed as correlation noise using PCA. Then the wavelet-threshold method was used to remove the independent white noise. Finally, EEMD was used to decompose the noise into the intrinsic modal function of each layer and remove the colored noise. The simulation results showed that PCWE can increase the signal-to-noise ratio by about 2.67 dB and decrease the standard deviation by about 0.4 μV, which apparently improved the accuracy of spike detection. The results of measured data showed that PCWE can increase the signal-to-noise ratio by about 1.33 dB and reduce the standard deviation by about 18.33 μV, which showed its good denoising performance. The results of this study suggests that PCWE can improve the reliability of spike signal and provide an accurate and effective spike denoising new method for the encoding and decoding of neural signal.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.7507/1001-5515.201906048DOI Listing
April 2020

Interleukin-33 alleviates psoriatic inflammation by suppressing the T helper type 17 immune response.

Immunology 2020 Aug 25;160(4):382-392. Epub 2020 May 25.

Department of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Psoriasis is a chronic inflammatory skin disease with unclear pathogenesis. Interleukin-33 (IL-33) is highly expressed in patients with psoriasis, but its role in psoriasis is unknown. The aim of this study was to investigate the possible role of IL-33 in the pathogenesis and treatment of psoriasis. IL-33 expression was determined using enzyme-linked immunosorbent assay, real-time fluorescent quantitative polymerase chain reaction and immunohistochemical staining. CD4 T cells were sorted using magnetic beads and treated with or without IL-33. Imiquimod (IMQ) was used to induce psoriatic inflammation in mice. The frequency of immune cells was determined using flow cytometry. The cytokine level in mouse skin was measured using cytometric bead array. Our results showed that IL-33 was highly expressed in the lesional skin and serum of patients with moderate-to-severe plaque psoriasis. IL-33 inhibited the expression of IL-17 in CD4 T cells of psoriasis patients. Subcutaneous injection of IL-33 alleviated the IMQ-induced psoriatic inflammation in mice, reduced tumor necrosis factor-α and IL-23 expression, and decreased the proportion of T helper type 17 (Th17) cells in the skin-draining lymph nodes in the mice. Our results suggest that IL-33 plays a protective role in the pathogenesis of psoriasis by suppressing Th17 cell differentiation and function. The potential therapeutic effect of IL-33 in treating psoriasis warrants further investigation.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/imm.13203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370137PMC
August 2020

The modification effect of the diurnal temperature range on the exposure-response relationship between temperature and pediatric hand, foot and mouth disease.

Sci Total Environ 2020 Jun 13;722:137921. Epub 2020 Mar 13.

Division of Infectious Disease & Key Laboratory of Surveillance and Early Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China.

Background: Growing evidence suggests that the diurnal temperature range (DTR) could modify the temperature-disease relationship for those environmentally-related infectious diseases. However, there is a lack of evidence on the hand, foot and mouth disease (HFMD). In this study, we thoroughly examined this hypothesis via a nationwide study.

Method: We collected the daily time series of HFMD cases and meteorological factors of 143 cities in mainland China from 2009 to 2014. For each city, we calculated the arithmetic average of the meteorological factors as a proxy for the climatic differences. We then performed two-stage time series analyses for four different climatic regions. Specifically, a distributed lag nonlinear model was applied to estimate the temperature-HFMD relationship for each city, and then a multivariate meta-regression was implemented to examine whether the DTR could explain the potential heterogeneity as an effect modifier. In addition, we compared the modification effect of the DTR with those of other climatic factors.

Result: We found a significant modification effect of DTR on the temperature-HFMD relationship in the moderate-temperature region. Besides, the modification effect was only observed at hot temperatures. Comparing the maximum temperature (32.2 °C) to the median temperature (11.9 °C), the risk ratio was 1.60 (1.33, 1.92) when DTR was in the 10th percentile (6.8 °C) and 0.81 (0.69, 0.96) when the DTR was in the 90th percentile (11.8 °C). By comparing DTR with other climatic variables, we found that the DTR had the best performance in improving the model fit (ΔQAIC= 10.1) and reducing the heterogeneity (ΔI = 3.1%) in the multivariate meta-regression.

Conclusion: Our findings verified that DTR can modify the temperature-HFMD relationship. Besides, our findings also implied that DTR could be used as a proxy variable to comprehensively reflect the modification effects of multiple climatic factors.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2020.137921DOI Listing
June 2020

Current Research and Use of Mesenchymal Stem Cells in the Therapy of Autoimmune Diseases.

Curr Stem Cell Res Ther 2019 ;14(7):579-582

Department of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.

Mesenchymal Stem Cells (MSCs) represent a heterogeneous group of self-renewal, multipotent non-hematopoietic stem cells, which display profound immunomodulatory functions and promising therapeutic effects. Autoimmune diseases, which result from an aberrant immune response to selfantigens, can be detrimental to nearly all body tissues. With the advance in developing a novel treatment, including biological agents, it is still impossible to cure autoimmune disorders. Recent studies demonstrate the remarkable therapeutic effectiveness of MSCs towards a wide array of autoimmune diseases. In this review, the immunomodulatory influence of MSCs over immune cells and the application of MSCs transplantation in treating autoimmune diseases are highlighted.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2174/1574888X14666190429141421DOI Listing
April 2020

Cutaneous phaeohyphomycosis caused by Pyrenochaeta unguis-hominis in a diabetic patient: A case report.

Australas J Dermatol 2020 May 13;61(2):e221-e222. Epub 2019 Nov 13.

Department of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Phaeohyphomycosis, caused by opportunistic rare fungi, has increasingly been reported in diabetic and immunosuppressed patients. Pyrenochaeta unguis-hominis (P. unguis-hominis), a member of the dematiaceae group, has been identified to cause human nail infection. We report a rare case of cutaneous phaeohyphomycosis in a diabetic female caused by P. unguis-hominis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajd.13177DOI Listing
May 2020