Publications by authors named "Yidan Qiu"

2 Publications

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Cortical myelin content mediates differences in affective temperaments.

J Affect Disord 2021 03 14;282:1263-1271. Epub 2021 Jan 14.

Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education; School of Psychology, Center for Studies of Psychological Application; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, 510631, China. Electronic address:

Background: Affective temperaments are regarded as subclinical forms and precursors of mental disorders. It may serve as candidates to facilitate the diagnosis and prediction of mental disorders. Cortical myelination likely characterizes the neurodevelopment and the evolution of cognitive functions and reflects brain functional demand. However, little is known about the relationship between affective temperaments and myelin plasticity. This study aims to analyze the association between the affective temperaments and cortical myelin content (CMC) in human brain.

Methods: We measured affective temperaments using the Temperament Evaluation of Memphis, Pisa, Paris and San Diego Autoquestionnaire (TEMPS-A) on 106 healthy adults and used the ratio of T1- and T2-weighted images as the proxy for CMC. Using the unsupervised k-means clustering algorithm, we classified the cortical gray matter into heavily, intermediately, and lightly myelinated regions. The correlation between affective temperaments and CMC was calculated separately for different myelinated regions.

Results: Hyperthymic temperament correlated negatively with CMC in the heavily myelinated (right postcentral gyrus and bilateral precentral gyrus) and lightly myelinated (bilateral frontal and lateral temporal) regions. Cyclothymic temperament showed a downward parabola-like correlation with CMC across the heavily, intermediately, and lightly myel0inated areas of the bilateral parietal-temporal regions.

Limitations: The analysis was constrained to cortical regions. The results were obtained from healthy subjects and we did not acquired data from patients of affective disorder, which may compromise the generalizability of the present findings.

Conclusion: The findings suggest that hyperthymic and cyclothymic temperaments have a CMC basis in extensive brain regions.
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March 2021

Representation of human spatial navigation responding to input spatial information and output navigational strategies: An ALE meta-analysis.

Neurosci Biobehav Rev 2019 08 12;103:60-72. Epub 2019 Jun 12.

Centre for the Study of Applied Psychology, Guangdong Key Laboratory of Mental Health and Cognitive Science, School of Psychology, Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou, 510631, PR China. Electronic address:

Spatial navigation is a crucial ability involving the interplay of multiple cognitive processes and is related to input spatial information (such as landmarks and orientation cues) and output navigational strategies (such as route-based and map-based). It is still not clear where is the spatial navigation system and whether these tasks evoke different activation patterns in human brain. Thus, we analyzed the reported brain activations of 33 related functional neuroimaging studies by using activation likelihood estimation (ALE) meta-analyses. Statistical analysis revealed a navigational system including the hippocampus, parahippocampal place area (PPA), retrosplenial complex (RSC), occipital place area (OPA), and insula. More likely, landmarks activate the left secondary motor cortex (SMC), whereas orientation cues activate the right somatosensory associative cortex (SAC). Although no region showed stronger activation likelihood in route- than map-based navigation, the map-based navigation had stronger activation likelihood in the right SAC than route-based navigation. These findings revealed the brain representation of spatial navigational system and suggested that different parts of this system are involved with the specific navigational tasks.
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August 2019