Yichun Wang, PhD - University of Michigan

Yichun Wang

PhD

University of Michigan

Ann Arbor, Michigan | United States

Additional Specialties: Biomedical Engineering

ORCID logohttps://orcid.org/0000-0002-4353-6660

Yichun Wang, PhD - University of Michigan

Yichun Wang

PhD

Introduction

Primary Affiliation: University of Michigan - Ann Arbor, Michigan , United States

Additional Specialties:

Education

Jan 2011 - Apr 2016
University of Michigan
PhD
Biomedical Engineering

Experience

May 2016
University of Michigan
Research Fellow

Publications

16Publications

365Reads

12Profile Views

47PubMed Central Citations

Diverse nanoassemblies of graphene quantum dots and their mineralogical counterparts.

Angew Chem Int Ed Engl 2019 Sep 1. Epub 2019 Sep 1.

RUSSIAN FEDERATION.

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http://dx.doi.org/10.1002/anie.201908216DOI Listing
September 2019
1 Read
11.261 Impact Factor

Predicting the Time of Entry of Nanoparticles in Lipid Membranes.

ACS Nano 2019 Sep 13. Epub 2019 Sep 13.

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http://dx.doi.org/10.1021/acsnano.9b03434DOI Listing
September 2019
12.881 Impact Factor

Anti-Biofilm Activity of Graphene Quantum Dots via Self-Assembly with Bacterial Amyloid Proteins.

ACS Nano 2019 Apr 4;13(4):4278-4289. Epub 2019 Apr 4.

Biointerfaces Institute , University of Michigan , Ann Arbor , Michigan 48109 , United States.

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http://dx.doi.org/10.1021/acsnano.8b09403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528478PMC
April 2019
1 Read
12.881 Impact Factor

Three-dimensional biomimetic scaffolds for hepatic differentiation of size-controlled embryoid bodies

Journal of Materials Research

Three-dimensional (3D) biomimetic scaffolds are critical for tissue engineering to support stem cell culture and organoid formation. Embryonic stem (ES) cells hold promising potential for tissue regeneration and ES cell-derived specific lineages are expected to be strongly influenced by the size of embryoid bodies (EBs). However, the fundamental knowledge needed to achieve the goal of highly reproducible, efficient, and scalable differentiation of how EB size affects differentiation is missing. Here, we used 3D biomimetic scaffolds with highly uniform porous structure to regulate size of EBs and differentiated them toward hepatic fate. The results showed EBs formed within the scaffolds were precisely controlled by pore sizes of the scaffolds. We found that EBs equals to or larger than 180 ± 27 µm maintained the ability to differentiate to hepatic lineage. The 3D biomimetic scaffold provides the effective tools toward accurate regulation of EB sizes for tissue engineering.

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March 2019
3 Reads

Layered biomimetic nanocomposites replicate bone surface in three-dimensional cell cultures

Nanocomposites 2019 Jan 03; 1-11.

Nanocomposites

Replication of bone marrow niches is essential for the evaluation of the toxicity and efficacy of multiple drug candidates and understanding of cell development. Recreation of the complex biological environment of bone marrow in a suitable format for such studies can be accomplished using bone-mimetic constructs based on three-dimensional (3D) nanocomposite-coated cell scaffolds with inverted colloidal crystal geometry. Layer-by-layer (LBL) assembled nanocomposites combine the mechanical properties and surface topography of bone with the transparency of 3D cell matrices. Such rare combination of properties allows for discrimination and control of complex biological processes such as differentiation of bone marrow stromal cells. LBL biomimetic nanocomposites open the pathway toward better understanding of the interactions between stromal cells and the extracellular matrix in the bone marrow microenvironment, in order to achieve the accurate engineering of the bone marrow niches.

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January 2019
3 Reads

Chiral Ceramic Nanoparticles and Peptide Catalysis.

J Am Chem Soc 2017 10 20;139(39):13701-13712. Epub 2017 Sep 20.

Department of Electrical and Electronics Engineering, Department of Physics, UNAM, Bilkent University , 06800 Ankara, Turkey.

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http://dx.doi.org/10.1021/jacs.7b01445DOI Listing
October 2017
39 Reads
12.113 Impact Factor

Chiral Graphene Quantum Dots.

ACS Nano 2016 Feb 15;10(2):1744-55. Epub 2016 Jan 15.

Department of Cogno-Mechatronics Engineering, Pusan National University , Miryang 627-706, Republic of Korea.

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http://dx.doi.org/10.1021/acsnano.5b06369DOI Listing
February 2016
104 Reads
12.881 Impact Factor

Anomalously Fast Diffusion of Targeted Carbon Nanotubes in Cellular Spheroids.

ACS Nano 2015 Aug 31;9(8):8231-8. Epub 2015 Jul 31.

Biointerfaces Institute, University of Michigan , North Campus Research Complex, 2800 Plymouth Road, Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1021/acsnano.5b02595DOI Listing
August 2015
34 Reads
5 Citations
12.881 Impact Factor

Anomalous dispersions of 'hedgehog' particles.

Nature 2015 Jan;517(7536):596-9

1] Department of Biomedical Engineering, University of Michigan, 1107 Carl A. Gerstacker Building, 2200 Bonisteel Boulevard, Ann Arbor, Michigan 48109, USA [2] Department of Chemical Engineering, University of Michigan, 3074 H.H. Dow Building, 2300 Hayward Street, Ann Arbor, Michigan 48109, USA [3] Macromolecular Science and Engineering Program, University of Michigan, 3062C H.H. Dow Building, 2300 Hayward Street, Ann Arbor, Michigan 48109, USA [4] Department of Material Science and Engineering, University of Michigan, 3074 H.H. Dow Building, 2300 Hayward Street, Ann Arbor, Michigan 48109, USA [5] Biointerfaces Institute, University of Michigan, North Campus Research Complex, 2800 Plymouth Road, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1038/nature14092DOI Listing
January 2015
29 Reads
6 Citations
42.351 Impact Factor

Replication of bone marrow differentiation niche: comparative evaluation of different three-dimensional matrices.

Small 2013 Apr 21;9(7):1008-15. Epub 2012 Dec 21.

Department of Chemical Engineering, University of Michigan, 2300 Hayward Street, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1002/smll.201202133DOI Listing
April 2013
16 Reads
4 Citations
8.370 Impact Factor

The influence of type-I collagen-coated PLLA aligned nanofibers on growth of blood outgrowth endothelial cells.

Biomed Mater 2010 Dec 9;5(6):065011. Epub 2010 Nov 9.

State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, People's Republic of China.

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http://dx.doi.org/10.1088/1748-6041/5/6/065011DOI Listing
December 2010
33 Reads
1 Citation
3.700 Impact Factor

Electrospun chitosan nanofibers for hepatocyte culture.

J Biomed Nanotechnol 2010 Dec;6(6):658-66

State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China.

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December 2010
13 Reads
3 Citations
5.340 Impact Factor

Stretched inverse opal colloid crystal substrates-induced orientation of fibroblast.

Biomed Mater 2010 Jun 27;5(3):35011. Epub 2010 May 27.

State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, People’s Republic of China.

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http://dx.doi.org/10.1088/1748-6041/5/3/035011DOI Listing
June 2010
19 Reads
1 Citation
3.700 Impact Factor

Rat hepatocyte aggregate formation on discrete aligned nanofibers of type-I collagen-coated poly(L-lactic acid).

Biomaterials 2010 May 9;31(13):3604-12. Epub 2010 Feb 9.

State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China.

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http://dx.doi.org/10.1016/j.biomaterials.2010.01.080DOI Listing
May 2010
19 Reads
3 Citations
8.560 Impact Factor

The effect of nanofibrous galactosylated chitosan scaffolds on the formation of rat primary hepatocyte aggregates and the maintenance of liver function.

Biomaterials 2009 May 20;30(14):2753-63. Epub 2009 Feb 20.

State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China.

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http://dx.doi.org/10.1016/j.biomaterials.2009.01.053DOI Listing
May 2009
57 Reads
24 Citations
8.560 Impact Factor

Establishment of Immortalized B Lymphoblast Cell Line from Patients with Hepatitis B Virus Infection.

乙型肝炎病毒感染者B淋巴母细胞系的建立[J].医学研究杂志,2008,(9)

医学研究杂志

目的 在体外建立HBV感染者永生化的B淋巴母细胞系(LCL),并鉴定其HLA-A基因亚型.方法 利用EB病毒转化外周血B淋巴细胞使之永生化,用环胞菌素A(Cys A)抑制血液中T淋巴细胞的活性;用PCR-SSP法检测血样本的HLA-A基因亚型.结果 成功建立了HBV感染者的永生细胞株16株,其中急性乙肝4例,慢性乙肝10例,携带者2例.所有的细胞株冻存后复苏的成功率为100%.细胞株的HLA-A基因亚型包括1101、0201、0101、2403等.结论 转化后的LCL保持了良好的稳定性,既可能作为人源单抗的来源,也可作为体外研究HBV特异性免疫应答的刺激细胞和靶细胞.永生化细胞HLA-A基因亚型的鉴定有可能使其成为异体相应亚型体外特异性免疫应答的刺激细胞和靶细胞.

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September 2008
14 Reads

Top co-authors

Nicholas A Kotov
Nicholas A Kotov

University of Michigan

5
Zhong-Ze Gu
Zhong-Ze Gu

Southeast University

4
Zhang-Qi Feng
Zhang-Qi Feng

Southeast University

4
Joong Hwan Bahng
Joong Hwan Bahng

University of Michigan

4
Angela Violi
Angela Violi

University of Michigan

3
Michelle K Leach
Michelle K Leach

University of Michigan

3
Paolo Elvati
Paolo Elvati

University of Michigan

3
Zhi-bei Qu
Zhi-bei Qu

East China Normal University

3
Ning-Ping Huang
Ning-Ping Huang

Southeast University

3
Shuang Jiang
Shuang Jiang

College of Pharmacy

2