Yichin Liu

Yichin Liu

UNVERIFIED PROFILE

Are you Yichin Liu?   Register this Author

Register author
Yichin Liu

Yichin Liu

Publications by authors named "Yichin Liu"

Are you Yichin Liu?   Register this Author

46Publications

1909Reads

27Profile Views

Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry.

Anal Chem 2020 Jan 10;92(2):2186-2193. Epub 2020 Jan 10.

Proteomics Center of Excellence , Northwestern University , 2170 Campus Drive , Evanston , Illinois 60208 , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.analchem.9b04826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008517PMC
January 2020

Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody-Drug Conjugates.

Drug Metab Dispos 2019 10 13;47(10):1156-1163. Epub 2019 May 13.

Drug Metabolism & Pharmacokinetics (D.Z., R.T.C., L.L., Y.D., C.E.C.A.H., S.C.K.), Biochemical and Cellular Pharmacology (A.F.-O., K.R.K., Y.L.), Discovery Chemistry (P.S.D., T.H.P.), and Protein Chemistry (J.D.S.), Genentech, Inc., South San Francisco, California

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.118.086132DOI Listing
October 2019

Automated On-tip Affinity Capture Coupled with Mass Spectrometry to Characterize Intact Antibody-Drug Conjugates from Blood.

J Am Soc Mass Spectrom 2018 07 29;29(7):1532-1537. Epub 2018 May 29.

Biochemical and Cellular Pharmacology, Genentech Inc, 1 DNA Way, South San Francisco, CA, 94080, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13361-018-1961-7DOI Listing
July 2018

Aminoisoxazoles as Potent Inhibitors of Tryptophan 2,3-Dioxygenase 2 (TDO2).

ACS Med Chem Lett 2018 May 2;9(5):417-421. Epub 2018 Apr 2.

Department of Discovery Chemistry, Department of Biochemical and Cellular Pharmacology, Department of Drug Metabolism and Pharmacokinetics, and Department of Translational Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acsmedchemlett.7b00427
Publisher Site
http://dx.doi.org/10.1021/acsmedchemlett.7b00427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949840PMC
May 2018

Identification of Small-Molecule Noncovalent Binders Utilizing SAMDI Technology.

SLAS Discov 2017 12 5;22(10):1211-1217. Epub 2017 Jun 5.

1 Biochemical and Cellular Pharmacology Department, Genentech Inc., San Francisco, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2472555217712761DOI Listing
December 2017

Automated Affinity Capture and On-Tip Digestion to Accurately Quantitate in Vivo Deamidation of Therapeutic Antibodies.

Anal Chem 2016 12 11;88(23):11521-11526. Epub 2016 Nov 11.

Biochemical and Cellular Pharmacology, ‡Protein Analytical Chemistry, §Immunology, ∥Antibody Engineering, and ⊥Preclinical and Translational Pharmacokinetics, Genentech, Inc. , South San Francisco, California 94080-4990, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.analchem.6b02766DOI Listing
December 2016

Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models.

J Med Chem 2015 Jan 23;58(1):401-18. Epub 2014 Oct 23.

Departments of †Discovery Chemistry, ‡Neurosciences, §Drug Metabolism and Pharmacokinetics, and ∥Biochemical and Cellular Pharmacology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm5013984DOI Listing
January 2015

Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase.

Chembiochem 2014 May 5;15(8):1121-30. Epub 2014 May 5.

Genentech, Inc., Department of Structural Biology, 1 DNA Way, South San Francisco, California 94080 (USA).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201402023DOI Listing
May 2014

Allosteric inhibition of BACE1 by an exosite-binding antibody.

Curr Opin Struct Biol 2013 Dec 30;23(6):797-805. Epub 2013 Aug 30.

Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sbi.2013.08.001DOI Listing
December 2013

Label-free high-throughput assays to screen and characterize novel lactate dehydrogenase inhibitors.

Anal Biochem 2013 Oct 16;441(2):115-22. Epub 2013 Jul 16.

Biochemical and Cellular Pharmacology, Genentech, South San Francisco, CA 94080, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ab.2013.07.003DOI Listing
October 2013

Assessment of the integrity of compounds stored in assay-ready plates using a kinase sentinel assay.

Comb Chem High Throughput Screen 2013 Sep;16(8):644-51

Therapeutic Discovery, Amgen, Inc., 1120 Veterans Blvd., South San Francisco, CA 94080 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/13862073113169990145DOI Listing
September 2013

Discovery of selective LRRK2 inhibitors guided by computational analysis and molecular modeling.

J Med Chem 2012 Jun 1;55(11):5536-45. Epub 2012 Jun 1.

Discovery Chemistry Department, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm300452pDOI Listing
June 2012

Case studies of minimizing nonspecific inhibitors in HTS campaigns that use assay-ready plates.

J Biomol Screen 2012 Feb 22;17(2):225-36. Epub 2011 Sep 22.

Biochemical Pharmacology & Early Leads, Genentech, Inc., South San Francisco, CA 90480, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1087057111421525DOI Listing
February 2012

Differential effects of divalent manganese and magnesium on the kinase activity of leucine-rich repeat kinase 2 (LRRK2).

Biochemistry 2010 Apr;49(14):3092-100

Biochemical Pharmacology and Early Leads, Genentech, Inc.,One DNA Way, South San Francisco, California 90480, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi901726cDOI Listing
April 2010

Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease.

Proc Natl Acad Sci U S A 2009 Mar 4;106(12):4635-40. Epub 2009 Mar 4.

Center for Neurologic Diseases, Brigham and Women's Hospital and Department of Neurology, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/content/106/12/4635.full.pdf
Web Search
http://www.pnas.org/cgi/doi/10.1073/pnas.0806474106
Publisher Site
http://dx.doi.org/10.1073/pnas.0806474106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651203PMC
March 2009

High-throughput assays for sirtuin enzymes: a microfluidic mobility shift assay and a bioluminescence assay.

Anal Biochem 2008 Jul 4;378(1):53-9. Epub 2008 Mar 4.

Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ab.2008.02.018DOI Listing
July 2008

Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.

Chem Biol 2003 Sep;10(9):837-46

Center for Neurologic Diseases, Brigham and Women's Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2003.08.010DOI Listing
September 2003

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.

Cell 2002 Oct;111(2):209-18

Center for Neurologic Diseases, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0092-8674(02)01012-7DOI Listing
October 2002