Publications by authors named "Yichen Zhou"

17 Publications

  • Page 1 of 1

Novel Probabilistic Neural Network Models Combined with Dissolved Gas Analysis for Fault Diagnosis of Oil-Immersed Power Transformers.

ACS Omega 2021 Jul 8;6(28):18084-18098. Epub 2021 Jul 8.

College of Information Engineering, Nanchang University, Nanchang 330031, China.

Fault diagnosis technology of power transformers is essential for the stable operation of power systems. Fault diagnosis technology based on dissolved gas analysis (DGA) is one of the most commonly used methods. However, due to the lack of fault information, traditional DGA fault diagnosis techniques are difficult to meet increasing power demand in terms of accuracy and efficiency. To address this problem, this paper proposes a novel fault diagnosis model for oil-immersed transformers based on International Electrotechnical Commission (IEC) ratio methods and probabilistic neural network (PNN) optimized with the modified moth flame optimization algorithm (MMFO). PNN as a radial neural network has good utility and is often used in classification models, but its classification performance is easily affected by the smoothing factor (σ) of the hidden layer and is not stable. This paper addresses this issue using the MMFO to optimize the smoothing factor, which effectively improves the classification accuracy and robustness of PNN. The proposed method was validated by conducting the experiments with the real data collected from transformers. Experimental results show that the MMFO-PNN model improves the fault diagnosis accuracy rate from 70.65 to 99.04%, which is higher than other power transformer fault diagnosis models.
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http://dx.doi.org/10.1021/acsomega.1c01878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296607PMC
July 2021

A Novel Transformers Fault Diagnosis Method Based on Probabilistic Neural Network and Bio-Inspired Optimizer.

Sensors (Basel) 2021 May 23;21(11). Epub 2021 May 23.

College of Information Engineering, Nanchang University, Nanchang 330031, China.

Since it is difficult for the traditional fault diagnosis method based on dissolved gas analysis (DGA) to meet today's engineering needs in terms of diagnostic accuracy and stability, this paper proposes an artificial intelligence fault diagnosis method based on a probabilistic neural network (PNN) and bio-inspired optimizer. The PNN is used as the basic classifier of the fault diagnosis model, and the bio-inspired optimizer, improved salp swarm algorithm (ISSA), is used to optimize the hidden layer smoothing factor of PNN, which stably improves the classification performance of PNN. Compared with the traditional SSA, the sine cosine algorithm (SCA) and disruption operator are introduced in ISSA, which effectively improves the exploration capability and convergence speed. To verify the engineering applicability of the proposed method, the ISSA-PNN model was developed and tested using sensor data provided by Jiangxi Province Power Supply Company. In addition, the method is compared with machine learning methods such as support vector machine (SVM), back propagation neural network (BPNN), multi-layer perceptron (MLP), and traditional fault diagnosis methods such as the international electrotechnical commission (IEC) ratio method. The results show that the proposed method has a strong learning ability for complex fault data and has advantages in accuracy and robustness compared to other methods.
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http://dx.doi.org/10.3390/s21113623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196968PMC
May 2021

Transcriptional signature in microglia associated with Aβ plaque phagocytosis.

Nat Commun 2021 05 21;12(1):3015. Epub 2021 May 21.

Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.

The role of microglia cells in Alzheimer's disease (AD) is well recognized, however their molecular and functional diversity remain unclear. Here, we isolated amyloid plaque-containing (using labelling with methoxy-XO4, XO4) and non-containing (XO4) microglia from an AD mouse model. Transcriptomics analysis identified different transcriptional trajectories in ageing and AD mice. XO4 microglial transcriptomes demonstrated dysregulated expression of genes associated with late onset AD. We further showed that the transcriptional program associated with XO4 microglia from mice is present in a subset of human microglia isolated from brains of individuals with AD. XO4 microglia displayed transcriptional signatures associated with accelerated ageing and contained more intracellular post-synaptic material than XO4 microglia, despite reduced active synaptosome phagocytosis. We identified HIF1α as potentially regulating synaptosome phagocytosis in vitro using primary human microglia, and BV2 mouse microglial cells. Together, these findings provide insight into molecular mechanisms underpinning the functional diversity of microglia in AD.
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http://dx.doi.org/10.1038/s41467-021-23111-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140091PMC
May 2021

Modelling human blastocysts by reprogramming fibroblasts into iBlastoids.

Nature 2021 Mar 17;591(7851):627-632. Epub 2021 Mar 17.

Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.

Human pluripotent and trophoblast stem cells have been essential alternatives to blastocysts for understanding early human development. However, these simple culture systems lack the complexity to adequately model the spatiotemporal cellular and molecular dynamics that occur during early embryonic development. Here we describe the reprogramming of fibroblasts into in vitro three-dimensional models of the human blastocyst, termed iBlastoids. Characterization of iBlastoids shows that they model the overall architecture of blastocysts, presenting an inner cell mass-like structure, with epiblast- and primitive endoderm-like cells, a blastocoel-like cavity and a trophectoderm-like outer layer of cells. Single-cell transcriptomics further confirmed the presence of epiblast-, primitive endoderm-, and trophectoderm-like cells. Moreover, iBlastoids can give rise to pluripotent and trophoblast stem cells and are capable of modelling, in vitro, several aspects of the early stage of implantation. In summary, we have developed a scalable and tractable system to model human blastocyst biology; we envision that this will facilitate the study of early human development and the effects of gene mutations and toxins during early embryogenesis, as well as aiding in the development of new therapies associated with in vitro fertilization.
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http://dx.doi.org/10.1038/s41586-021-03372-yDOI Listing
March 2021

Characterization of patients with advanced chronic pancreatitis using natural language processing of radiology reports.

PLoS One 2020 19;15(8):e0236817. Epub 2020 Aug 19.

Center for Pancreatic Care, Division of Gastroenterology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California, United States of America.

Study Aim: To develop and apply a natural language processing algorithm for characterization of patients diagnosed with chronic pancreatitis in a diverse integrated U.S. healthcare system.

Methods: Retrospective cohort study including patients initially diagnosed with chronic pancreatitis (CP) within a regional integrated healthcare system between January 1, 2006 and December 31, 2015. Imaging reports from these patients were extracted from the electronic medical record system and split into training, validation and implementation datasets. A natural language processing (NLP) algorithm was first developed through the training dataset to identify specific features (atrophy, calcification, pseudocyst, cyst and main duct dilatation) from free-text radiology reports. The validation dataset was applied to validate the performance by comparing against the manual chart review. The developed algorithm was then applied to the implementation dataset. We classified patients with calcification(s) or ≥2 radiographic features as advanced CP. We compared etiology, comorbid conditions, treatment parameters as well as survival between advanced CP and others diagnosed during the study period.

Results: 6,346 patients were diagnosed with CP during the study period with 58,085 radiology studies performed. For individual features, NLP yielded sensitivity from 88.7% to 95.3%, specificity from 98.2% to 100.0%. A total of 3,672 patients met cohort inclusion criteria: 1,330 (36.2%) had evidence of advanced CP. Patients with advanced CP had increased frequency of smoking (57.8% vs. 43.0%), diabetes (47.6% vs. 35.9%) and underweight body mass index (6.6% vs. 3.6%), all p<0.001. Mortality from pancreatic cancer was higher in advanced CP (15.3/1,000 person-year vs. 2.8/1,000, p<0.001). Underweight BMI (HR 1.6, 95% CL 1.2, 2.1), smoking (HR 1.4, 95% CL 1.1, 1.7) and diabetes (HR 1.4, 95% CL 1.2, 1.6) were independent risk factors for mortality.

Conclusion: Patients with advanced CP experienced increased disease-related complications and pancreatic cancer-related mortality. Excess all-cause mortality was driven primarily by potentially modifiable risk factors including malnutrition, smoking and diabetes.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0236817PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437899PMC
October 2020

Upper Excited State Photophysics of Malachite Green in Solution and Films.

J Phys Chem B 2020 05 15;124(21):4293-4302. Epub 2020 May 15.

State Key Laboratory of Fine Chemicals, Institute of Artificial Photosynthesis, Dalian University of Technology, 116024 Dalian, China.

Relaxation pathways of upper excited electronic states of malachite green (MG) in ethanol and in films are studied by steady-state and time-resolved spectroscopic techniques. In contrast to ethanol, where MG emits weak short-lived spectrally well separated S and S fluorescence with the lifetimes ∼0.3 and ∼0.9 ps, MG films show a much stronger broadband fluorescence within 430-700 nm, revealing multiexponential kinetics with the characteristic decay times τ ≈ 1 ps, τ ≈ 10 ps, τ ≈ 0.05-0.8 ns, and τ ≈ 2-3 ns. By the analysis of spectroscopic responses of MG in ethanol and in films as well as by theoretical modeling, we demonstrate that significant increase of fluorescence lifetimes and substantial enhancement of fluorescence intensity in MG films are stipulated by the decrease of efficiency of the S → S and S → S internal conversion, which in turn is caused by hindrance of rotation of MG's phenyl rings controlling the S/S and S/S conical intersections. These findings indicate that MG films may become promising non-Kasha materials (with reasonable S emission) with numerous photophysical and photochemical applications.
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http://dx.doi.org/10.1021/acs.jpcb.0c01737DOI Listing
May 2020

Etched ZIF-8 as a Filler in Mixed-Matrix Membranes for Enhanced CO /N Separation.

Chemistry 2020 Jun 29;26(35):7918-7922. Epub 2020 May 29.

College of Chemical Engineering, Jiangsu Key Laboratory for the Chemistry & Utilization of Agricultural and Forest Biomass, Jiangsu Key Laboratory of Biomass-Based Green Fuels and Chemicals, Nanjing Forestry University Department, Nanjing, Jiangsu, 210037, P.R. China.

Zeolite ZIF-8 has been etched with acid to form microporous ZIF-8-E crystals. These were then introduced into a polyethersulfone (PES) membrane matrix to enhance its CO /N separation performance. Open through pores of size about 100 nm formed in the ZIF-8 crystals allow the ingrowth of polyethersulfone chains, ensuring a reduction in the number of nonselective voids, thereby achieving better interaction between ZIF-8-E and PES. As a result, the CO /N separation performance of the ZIF-8-E/PES membrane increased significantly, showing a CO permeability of 15.7 Barrer and a CO /N ideal selectivity of 6.5.
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http://dx.doi.org/10.1002/chem.202000965DOI Listing
June 2020

Prediction of Pancreatic Cancer Based on Imaging Features in Patients With Duct Abnormalities.

Pancreas 2020 03;49(3):413-419

Center for Pancreatic Care, Department of Gastroenterology, Los Angeles Medical Center, Southern California Permanente Medical Group, Los Angeles, CA.

Objectives: Abnormalities of the main pancreatic duct may be an early indicator of pancreatic ductal adenocarcinoma (PDAC). We develop and validate algorithms that predict the risk of PDAC using features identified on cross-sectional imaging and other clinical characteristics collected through electronic medical records.

Methods: Adult patients with abdominal computed tomography or magnetic resonance imaging in January 2006 to June 2016 demonstrating dilatation of main pancreatic duct were identified. Pancreas-related morphologic features were extracted from radiology reports using natural language processing. The cumulative incidence of PDAC with death as a competing risk was estimated using multistate models. Model discrimination was assessed using c-index. The models were internally validated using bootstrapping.

Results: The cohort consisted of 7819 patients (mean age, 71 years; 65% female). A total of 781 patients (10%) developed PDAC within 3 years after the first eligible imaging study. The final models achieved reasonable discrimination (c-index, 0.825-0.833). The 3-year average risk of PDAC in the top 5% of the total eligible patients was 56.0%, more than 20 times of the average risk among the bottom 50% of patients.

Conclusions: Prediction models combining imaging features and clinical measures can be used to further stratify the risk of pancreatic cancer among patients with pancreas ductal dilatation.
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http://dx.doi.org/10.1097/MPA.0000000000001499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444654PMC
March 2020

Functionalized Superwettable Fabric with Switchable Wettability for Efficient Oily Wastewater Purification, in Situ Chemical Reaction System Separation, and Photocatalysis Degradation.

ACS Appl Mater Interfaces 2019 Nov 7;11(46):43751-43765. Epub 2019 Nov 7.

College of Chemistry and Chemical Engineering , Xi'an University of Science and Technology , Xi'an 710054 , Shaanxi , China.

In view of the increasing serious water environmental and human health issues caused by oily wastewater, functional superwetting materials with controllable wettability, high durability, and scale preparation methods are highly desired for efficient oil/water separation. In this respect, a pH-responsive multifunctional fabric with switchable surface wettability, favorable mechanical durability, and self-repairing property has been developed via decorating the modified TiO nanoparticles of special surface compositions onto the fabric surface. By virtue of the intelligent surface wettability, the resulted superwettable fabric can be used for controllable separation of multiple oil/water mixtures, particularly the complicated oil/water/oil ternary mixtures, showing excellent separation efficiency and high filtration flux even under extreme pH conditions, which is comparable to most of the commercial and currently reported functionalized membranes. Simultaneously, the negative pressure-driven, continuous, high-speed, and highly efficient in situ purification of large volumes of oily wastewater is successfully achieved based on the resulted superwettable fabric. More importantly, with the as-prepared superwettable fabric as the filtration membrane, the continuous in situ separation of the synthetic oily product from the corresponding chemical reaction systems is well performed without interruption of the reaction, demonstrating outstanding merits of simplifying procedures, saving operation time, and increasing product yield. In addition, it is worth noting that the alkali-treated superhydrophilic fabric presents superior photocatalysis self-cleaning performance for various water-soluble organic pollutants. These unique advantages of the functionalized smart superwettable fabric ensure that it can be competent in multifarious relevant challenging settings, indicating a broad prospect for diverse practical applications, especially the oily wastewater treatment and multiple industrial operation optimizations.
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http://dx.doi.org/10.1021/acsami.9b15952DOI Listing
November 2019

Manual acupuncture for the infertile female with polycystic ovary syndrome (PCOS): study protocol for a randomized sham-controlled trial.

Trials 2019 Sep 11;20(1):564. Epub 2019 Sep 11.

Acupuncture & Tuina School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases for women. Acupuncture is widely used for the infertile female because of it is non-invasive and has fewer side effects, but the powerful evidence for the clinic is still insufficient. Our study intends to explore the effect of manual acupuncture (MA) in the infertile female with PCOS.

Methods: This study is a randomized, sham-controlled, patient-and assessor-blinded trial and aims to evaluate the effect of MA in women with PCOS and infertility. We will recruit 86 women aged 20-40 years with a diagnosis of infertility with PCOS. Participants will be randomly allocated in a 1:1 ratio to the MA group and the sham acupuncture (SA) group. Both groups will receive real herbal medicine treatment as a basic treatment twice a day for three menstrual cycles, the MA group receive real acupuncture treatment and the SA group received placebo acupuncture treatment (non-penetrating). All patients will receive acupuncture treatment twice per week for three menstrual cycles. The primary outcome is pregnancy rate and secondary outcomes include ovulation rate, sex hormones, insulin resistance index (IRI), PCOS symptoms, and Traditional Chinese Medicine (TCM) syndrome scores. Outcome measures will be collected at baseline, each menstrual cycle, the end of treatments, and six months after the last acupuncture treatment. The present protocol followed the SPIRIT guidelines and fulfilled the SPIRIT checklist.

Discussion: This study will be conducted to compare the efficacy of MA versus SA. This trial will help to evaluate whether MA is effective in increasing pregnancy and ovulation rates of the infertile female with polycystic ovary syndrome.

Trial Registration: Chinese Clinical Trial Registry, ChiCTR1800014997 . Registered on 27 February 2018.
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http://dx.doi.org/10.1186/s13063-019-3667-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739979PMC
September 2019

Development and characterization of a hydroxypropyl starch/zein bilayer edible film.

Int J Biol Macromol 2019 Dec 29;141:1175-1182. Epub 2019 Aug 29.

Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou, Guangdong, China. Electronic address:

An edible hydroxypropyl starch (HPS) based bilayer film with a waterproof layer of zein was successfully prepared through a two-step solvent casting method. The morphology, mechanical properties, as well as water barrier properties of the bilayer film were systematically studied. Results showed that bilayer film presented smooth surface morphology with an improved visibility, and there was an adhesion interface between two layers. Water resistance and UV barrier property, as well as mechanical property, were significantly improved. In addition, the interactions between starch and zein through hydrogen bonding were analyzed by Fourier-transform infrared spectroscopy (FTIR) and molecular dynamics (MD) simulation. In MD simulation, the relative trajectories were dynamically presented. Conjunction of starch and zein through hydrogen bonding among the hydroxyl and amino (carboxyl) groups was identified, and stronger affinity with starch mainly rooted from asparagine (ASN) and tyrosine (TYR) residues.
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http://dx.doi.org/10.1016/j.ijbiomac.2019.08.240DOI Listing
December 2019

Multifunctional Superwettable Material with Smart pH Responsiveness for Efficient and Controllable Oil/Water Separation and Emulsified Wastewater Purification.

ACS Appl Mater Interfaces 2019 Jul 27;11(27):24668-24682. Epub 2019 Jun 27.

College of Chemistry and Chemical Engineering , Xi'an University of Science and Technology , Xi'an 710054 , China.

Developing multifunctional superwettable materials is highly demanded in the oil/water separation field but remains challenging due to the critical limitations of complex fabrication strategy and high cost. Herein, based on the cost-effective kaolin nanoparticles, we present a convenient and mild strategy for fabricating a smart superwettable material with multiple excellent performances, such as pH-responsive water wettability, self-cleaning property, favorable buoyancy, and air purification performance. By virtue of the dual rough surface structure and special chemical composition, the resultant material surface exhibits a superior pH-dependent wettability, which can be reversibly switched between superamphiphobicity and superhydrophilicity-superoleophobicity for many times in accordance with the pH value of the corresponding aqueous solution. As a result, the obtained superwettable material with reversible and controllable water wettability can be applied in efficient and continuous separation of multiple types of oil/water mixtures, especially the highly emulsified oil/water emulsions, via in situ or ex situ wettability change. To our knowledge, the smart material with the wetting property of superamphiphobicity that can be used for continuous emulsified wastewater purification has been rarely discussed in the emerging research works. In addition, the as-prepared material presents universal applicability to diversiform substrates and exhibits robust durability and stability against high-concentration salt solutions and rigorous mechanical abrasion. All of these above-mentioned advantages indicate that the as-prepared superwettable material will hold great potential in various practical applications, including oily wastewater remediation, smart aquatic device fabrication, liquid droplet manipulation, guiding liquid movement, and optimizing multiple operations in industrial fields.
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http://dx.doi.org/10.1021/acsami.9b03721DOI Listing
July 2019

Tprn is essential for the integrity of stereociliary rootlet in cochlear hair cells in mice.

Front Med 2019 Dec 30;13(6):690-704. Epub 2018 Aug 30.

School of Life Science, Shandong University, Jinan, 250100, China.

Tprn encodes the taperin protein, which is concentrated in the tapered region of hair cell stereocilia in the inner ear. In humans, TPRN mutations cause autosomal recessive nonsyndromic deafness (DFNB79) by an unknown mechanism. To determine the role of Tprn in hearing, we generated Tprn-null mice by clustered regularly interspaced short palindromic repeat/Cas9 genome-editing technology from a CBA/CaJ background. We observed significant hearing loss and progressive degeneration of stereocilia in the outer hair cells of Tprn-null mice starting from postnatal day 30. Transmission electron microscopy images of stereociliary bundles in the mutant mice showed some stereociliary rootlets with curved shafts. The central cores of the stereociliary rootlets possessed hollow structures with surrounding loose peripheral dense rings. Radixin, a protein expressed at stereocilia tapering, was abnormally dispersed along the stereocilia shafts in Tprn-null mice. The expression levels of radixin and β-actin significantly decreased.We propose that Tprn is critical to the retention of the integrity of the stereociliary rootlet. Loss of Tprn in Tprn-null mice caused the disruption of the stereociliary rootlet, which resulted in damage to stereociliary bundles and hearing impairments. The generated Tprn-null mice are ideal models of human hereditary deafness DFNB79.
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http://dx.doi.org/10.1007/s11684-018-0638-8DOI Listing
December 2019

A Data-driven Process Recommender Framework.

KDD 2017 Aug;2017:2111-2120

Rutgers University, NJ.

We present an approach for improving the performance of complex knowledge-based processes by providing data-driven step-by-step recommendations. Our framework uses the associations between similar historic process performances and contextual information to determine the prototypical way of enacting the process. We introduce a novel similarity metric for grouping traces into clusters that incorporates temporal information about activity performance and handles concurrent activities. Our data-driven recommender system selects the appropriate prototype performance of the process based on user-provided context attributes. Our approach for determining the prototypes discovers the commonly performed activities and their temporal relationships. We tested our system on data from three real-world medical processes and achieved recommendation accuracy up to an F1 score of 0.77 (compared to an F1 score of 0.37 using ZeroR) with 63.2% of recommended enactments being within the first five neighbors of the actual historic enactments in a set of 87 cases. Our framework works as an interactive visual analytic tool for process mining. This work shows the feasibility of data-driven decision support system for complex knowledge-based processes.
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http://dx.doi.org/10.1145/3097983.3098174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231407PMC
August 2017

Loss of Myh14 Increases Susceptibility to Noise-Induced Hearing Loss in CBA/CaJ Mice.

Neural Plast 2016 22;2016:6720420. Epub 2016 Dec 22.

School of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 250100, China.

MYH14 is a member of the myosin family, which has been implicated in many motile processes such as ion-channel gating, organelle translocation, and the cytoskeleton rearrangement. Mutations in MYH14 lead to a DFNA4-type hearing impairment. Further evidence also shows that MYH14 is a candidate noise-induced hearing loss (NIHL) susceptible gene. However, the specific roles of MYH14 in auditory function and NIHL are not fully understood. In the present study, we used CRISPR/Cas9 technology to establish a Myh14 knockout mice line in CBA/CaJ background (now referred to as Myh14 mice) and clarify the role of MYH14 in the cochlea and NIHL. We found that Myh14 mice did not exhibit significant hearing loss until five months of age. In addition, Myh14 mice were more vulnerable to high intensity noise compared to control mice. More significant outer hair cell loss was observed in Myh14 mice than in wild type controls after acoustic trauma. Our findings suggest that Myh14 may play a beneficial role in the protection of the cochlea after acoustic overstimulation in CBA/CaJ mice.
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http://dx.doi.org/10.1155/2016/6720420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215640PMC
October 2017

Dynamic tubulation of mitochondria drives mitochondrial network formation.

Cell Res 2015 Oct 24;25(10):1108-20. Epub 2015 Jul 24.

State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University-Peking University Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Mitochondria form networks. Formation of mitochondrial networks is important for maintaining mitochondrial DNA integrity and interchanging mitochondrial material, whereas disruption of the mitochondrial network affects mitochondrial functions. According to the current view, mitochondrial networks are formed by fusion of individual mitochondria. Here, we report a new mechanism for formation of mitochondrial networks through KIF5B-mediated dynamic tubulation of mitochondria. We found that KIF5B pulls thin, highly dynamic tubules out of mitochondria. Fusion of these dynamic tubules, which is mediated by mitofusins, gives rise to the mitochondrial network. We further demonstrated that dynamic tubulation and fusion is sufficient for mitochondrial network formation, by reconstituting mitochondrial networks in vitro using purified fusion-competent mitochondria, recombinant KIF5B, and polymerized microtubules. Interestingly, KIF5B only controls network formation in the peripheral zone of the cell, indicating that the mitochondrial network is divided into subzones, which may be constructed by different mechanisms. Our data not only uncover an essential mechanism for mitochondrial network formation, but also reveal that different parts of the mitochondrial network are formed by different mechanisms.
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http://dx.doi.org/10.1038/cr.2015.89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650629PMC
October 2015
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