Yian Wang

Yian Wang

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Neoantigen vaccine: an emerging tumor immunotherapy.

Mol Cancer 2019 Aug 23;18(1):128. Epub 2019 Aug 23.

NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.

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http://dx.doi.org/10.1186/s12943-019-1055-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708248PMC
August 2019

Tumor intrinsic immunity related proteins may be novel tumor suppressors in some types of cancer.

Sci Rep 2019 Jul 29;9(1):10918. Epub 2019 Jul 29.

Center for Disease Prevention Research and Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.

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http://dx.doi.org/10.1038/s41598-019-47382-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662687PMC
July 2019

Optimized Bexarotene Aerosol Formulation Inhibits Major Subtypes of Lung Cancer in Mice.

Nano Lett 2019 04 21;19(4):2231-2242. Epub 2019 Mar 21.

Department of Chemistry and Biochemistry , University of Wisconsin , Milwaukee , Wisconsin 53211 , United States.

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http://dx.doi.org/10.1021/acs.nanolett.8b04309DOI Listing
April 2019

Exosomal miRNAs as Novel Pharmacodynamic Biomarkers for Cancer Chemopreventive Agent Early Stage Treatments in Chemically Induced Mouse Model of Lung Squamous Cell Carcinoma.

Cancers (Basel) 2019 Apr 4;11(4). Epub 2019 Apr 4.

Center for Disease Prevention and Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.3390/cancers11040477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520832PMC
April 2019

Co-delivery doxorubicin and silybin for anti-hepatoma via enhanced oral hepatic-targeted efficiency.

Int J Nanomedicine 2019 28;14:301-315. Epub 2018 Dec 28.

Drug Delivery Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, People's Republic of China,

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https://www.dovepress.com/co-delivery-doxorubicin-and-silybi
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http://dx.doi.org/10.2147/IJN.S187888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314320PMC
February 2019

Natural killer group 2D receptor and its ligands in cancer immune escape.

Mol Cancer 2019 02 27;18(1):29. Epub 2019 Feb 27.

NHC Key Laboratory of Carcinogenesis (Central South University) and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.

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http://dx.doi.org/10.1186/s12943-019-0956-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391774PMC
February 2019

Immunogenomic Landscape Contributes to Hyperprogressive Disease after Anti-PD-1 Immunotherapy for Cancer.

iScience 2018 Nov 25;9:258-277. Epub 2018 Oct 25.

Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA; Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S25890042183018
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http://dx.doi.org/10.1016/j.isci.2018.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234258PMC
November 2018

Airway brushing as a new experimental methodology to detect airway gene expression signatures in mouse lung squamous cell carcinoma.

Sci Rep 2018 Jun 11;8(1):8895. Epub 2018 Jun 11.

Cancer Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.

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http://dx.doi.org/10.1038/s41598-018-26902-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995924PMC
June 2018

Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity.

iScience 2018 May 22;3:192-207. Epub 2018 Apr 22.

Cancer Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA; Department of Pharmacology & Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2018.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137433PMC
May 2018

Novel mutational landscapes and expression signatures of lung squamous cell carcinoma.

Oncotarget 2018 Jan 27;9(7):7424-7441. Epub 2017 Dec 27.

Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.18632/oncotarget.23716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800913PMC
January 2018

Immunoprevention of KRAS-driven lung adenocarcinoma by a multipeptide vaccine.

Oncotarget 2017 Oct 1;8(47):82689-82699. Epub 2017 Aug 1.

Cancer Center and Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA.

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http://dx.doi.org/10.18632/oncotarget.19831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669920PMC
October 2017

Fourier transform large amplitude alternating current voltammetry investigations of the split wave phenomenon in electrocatalytic mechanisms.

Phys Chem Chem Phys 2017 Sep;19(35):24304-24315

Beijing Key Laboratory for Green Catalysis and Separation, Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.

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http://dx.doi.org/10.1039/c7cp03510aDOI Listing
September 2017

Effect of weekly or daily dosing regimen of Gefitinib in mouse models of lung cancer.

Oncotarget 2017 Sep 2;8(42):72447-72456. Epub 2017 Aug 2.

Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.18632/oncotarget.19785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641144PMC
September 2017

Honokiol Decreases Lung Cancer Metastasis through Inhibition of the STAT3 Signaling Pathway.

Cancer Prev Res (Phila) 2017 Feb 14;10(2):133-141. Epub 2016 Nov 14.

Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.

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http://dx.doi.org/10.1158/1940-6207.CAPR-16-0129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005650PMC
February 2017

Honokiol targets mitochondria to halt cancer progression and metastasis.

Mol Nutr Food Res 2016 06 6;60(6):1383-95. Epub 2016 May 6.

Medical College of Wisconsin Cancer Center and Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA.

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http://dx.doi.org/10.1002/mnfr.201501007DOI Listing
June 2016

Inhibition of IGF1R signaling abrogates resistance to afatinib (BIBW2992) in EGFR T790M mutant lung cancer cells.

Mol Carcinog 2016 May 4;55(5):991-1001. Epub 2015 Jun 4.

Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin.

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http://dx.doi.org/10.1002/mc.22342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003619PMC
May 2016

PARK2 gene and familial lung cancer: what is the link?

Future Oncol 2015 ;11(12):1707-10

Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.2217/fon.15.79DOI Listing
March 2016

Targeting the insulin-like growth factor-1 receptor by picropodophyllin for lung cancer chemoprevention.

Mol Carcinog 2015 Jun 27;54 Suppl 1:E129-37. Epub 2014 Aug 27.

Medical College of Wisconsin Cancer Center and Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin.

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http://dx.doi.org/10.1002/mc.22206DOI Listing
June 2015

Enhanced antitumor activity of 3-bromopyruvate in combination with rapamycin in vivo and in vitro.

Cancer Prev Res (Phila) 2015 Apr 2;8(4):318-26. Epub 2015 Feb 2.

Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin. Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin.

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http://dx.doi.org/10.1158/1940-6207.CAPR-14-0142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004825PMC
April 2015

A recurrent mutation in PARK2 is associated with familial lung cancer.

Am J Hum Genet 2015 Feb 29;96(2):301-8. Epub 2015 Jan 29.

Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA; Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320264PMC
February 2015

Dietary diindolylmethane suppresses inflammation-driven lung squamous cell carcinoma in mice.

Cancer Prev Res (Phila) 2015 Jan 17;8(1):77-85. Epub 2014 Nov 17.

Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota. College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota.

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http://dx.doi.org/10.1158/1940-6207.CAPR-14-0245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289649PMC
January 2015

Honokiol inhibits lung tumorigenesis through inhibition of mitochondrial function.

Cancer Prev Res (Phila) 2014 Nov 22;7(11):1149-59. Epub 2014 Sep 22.

Medical College of Wisconsin Cancer Center and Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin.

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http://dx.doi.org/10.1158/1940-6207.CAPR-14-0091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010030PMC
November 2014

Transcriptomic analysis by RNA-seq reveals AP-1 pathway as key regulator that green tea may rely on to inhibit lung tumorigenesis.

Mol Carcinog 2014 Jan 31;53(1):19-29. Epub 2012 Jul 31.

Department of Surgery, The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri; Medical College of Wisconsin Cancer Center, Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin.

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http://doi.wiley.com/10.1002/mc.21941
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http://dx.doi.org/10.1002/mc.21941DOI Listing
January 2014

Design, synthesis, and assessment of a de novo affinity adsorbent for the purification of recombinant human erythropoietin.

Biotechnol Bioeng 2013 Nov 16;110(11):3063-9. Epub 2013 May 16.

Department of Chemical Engineering and Biotechnology, Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QT, United Kingdom.

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http://dx.doi.org/10.1002/bit.24943DOI Listing
November 2013

Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis.

Mol Carcinog 2013 Sep 27;52(9):686-91. Epub 2012 Mar 27.

Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1002/mc.21907DOI Listing
September 2013

Mouse models of lung squamous cell carcinomas.

Cancer Metastasis Rev 2013 Jun;32(1-2):77-82

Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1007/s10555-012-9406-4DOI Listing
June 2013

Chemoprevention of lung squamous cell carcinoma by ginseng.

Cancer Prev Res (Phila) 2013 Jun 2;6(6):530-9. Epub 2013 Apr 2.

Medical College of Wisconsin Cancer Center and Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-12-0366DOI Listing
June 2013

Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemically induced oral carcinogenesis.

Mol Carcinog 2013 Jan 15;52(1):49-56. Epub 2011 Nov 15.

Department of Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://doi.wiley.com/10.1002/mc.20877
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http://dx.doi.org/10.1002/mc.20877DOI Listing
January 2013

Lung cancer chemoprevention: difficulties, promise and potential agents?

Expert Opin Investig Drugs 2013 Jan 21;22(1):35-47. Epub 2012 Nov 21.

Hitchcock Cancer Center, Dartmoth Medical School, Lebanon, NH, USA.

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http://dx.doi.org/10.1517/13543784.2013.731392DOI Listing
January 2013

Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus.

PLoS One 2012 4;7(6):e36116. Epub 2012 Jun 4.

MCW Cancer Center, Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036116PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366984PMC
October 2012

Animal models of lung cancer characterization and use for chemoprevention research.

Prog Mol Biol Transl Sci 2012 ;105:211-26

Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1016/B978-0-12-394596-9.00007-XDOI Listing
May 2012

MicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer.

Carcinogenesis 2012 May 13;33(5):1046-54. Epub 2012 Feb 13.

Department of Physiology and Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.1093/carcin/bgs100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334512PMC
May 2012

Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity.

Cancer Prev Res (Phila) 2012 May 8;5(5):717-25. Epub 2012 Mar 8.

Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-11-0338DOI Listing
May 2012

Genome-wide association and fine mapping of genetic loci predisposing to colon carcinogenesis in mice.

Mol Cancer Res 2012 Jan 29;10(1):66-74. Epub 2011 Nov 29.

Department of Physiology and the Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-10-0540DOI Listing
January 2012

Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice.

Mol Carcinog 2011 Dec 3;50(12):913-21. Epub 2011 Mar 3.

Department of Energy, Environmental and Chemical Engineering, Washington University in St Louis, St Louis, Missouri 63110, USA.

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http://doi.wiley.com/10.1002/mc.20751
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http://dx.doi.org/10.1002/mc.20751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015734PMC
December 2011

Aerosolized bexarotene inhibits lung tumorigenesis without increasing plasma triglyceride and cholesterol levels in mice.

Cancer Prev Res (Phila) 2011 Feb 16;4(2):270-6. Epub 2010 Dec 16.

Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-10-0246DOI Listing
February 2011

Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in mice.

Mol Cancer Ther 2010 Nov 2;9(11):3074-82. Epub 2010 Nov 2.

Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-10-0510DOI Listing
November 2010

26S proteasome activity is down-regulated in lung cancer stem-like cells propagated in vitro.

PLoS One 2010 Oct 11;5(10):e13298. Epub 2010 Oct 11.

Department of Surgery, Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013298PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952619PMC
October 2010

A dominant-negative c-jun mutant inhibits lung carcinogenesis in mice.

Cancer Prev Res (Phila) 2010 Sep 17;3(9):1148-56. Epub 2010 Aug 17.

Department of Surgery, The Alvin J. Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-10-0023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933283PMC
September 2010

Effect of dietary Polyphenon E and EGCG on lung tumorigenesis in A/J Mice.

Pharm Res 2010 Jun 29;27(6):1066-71. Epub 2010 Jan 29.

Department of Surgery and Alvin J Siteman Cancer Center, Washington University in St. Louis, 660 South Euclid Avenue, Campus Box 8109, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1007/s11095-010-0056-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007862PMC
June 2010

Preventive effects of bexarotene and budesonide in a genetically engineered mouse model of small cell lung cancer.

Cancer Prev Res (Phila) 2009 Dec 24;2(12):1059-64. Epub 2009 Nov 24.

Department of Surgery and The Alvin J. Siteman Cancer Center and Division of Comparative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://cancerpreventionresearch.aacrjournals.org/cgi/doi/10.
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http://dx.doi.org/10.1158/1940-6207.CAPR-09-0221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001362PMC
December 2009

Induced expression of drug metabolizing enzymes by preventive agents: role of the antioxidant response element.

Chem Biol Interact 2009 Nov 18;182(1):22-8. Epub 2009 Aug 18.

Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000927970900326
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http://dx.doi.org/10.1016/j.cbi.2009.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642098PMC
November 2009

Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus.

Cancer Res 2009 Aug 21;69(15):6290-8. Epub 2009 Jul 21.

Department of Surgery and the Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-0782DOI Listing
August 2009

Chemoprevention of lung squamous cell carcinoma in mice by a mixture of Chinese herbs.

Cancer Prev Res (Phila) 2009 Jul;2(7):634-40

Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-09-0052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890236PMC
July 2009

Quantitative monitoring of adenocarcinoma development in rodents by magnetic resonance imaging.

Clin Cancer Res 2008 Mar;14(5):1363-7

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-1757DOI Listing
March 2008

Enhanced susceptibility to chemical induction of ovarian tumors in mice with a germ line p53 mutation.

Mol Cancer Res 2008 Jan;6(1):99-109

Department of Surgery, The Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-07-0216DOI Listing
January 2008

Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb.

J Biol Chem 2007 Dec 10;282(49):35803-13. Epub 2007 Oct 10.

Life Sciences Institute, University of Michigan, Ann Arbor, 48109, USA.

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http://dx.doi.org/10.1074/jbc.M705231200DOI Listing
December 2007

Enhanced lung tumor development in tobacco smoke-exposed p53 transgenic and Kras2 heterozygous deficient mice.

Inhal Toxicol 2007 ;19 Suppl 1:183-7

Department of Surgery, Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1080/08958370701496160 DOI Listing
November 2007

Degradation of lung adenoma susceptibility 1, a major candidate mouse lung tumor modifier, is required for cell cycle progression.

Cancer Res 2007 Nov;67(21):10207-13

Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-2574DOI Listing
November 2007

Chemopreventive effect of aerosolized polyphenon E on lung tumorigenesis in A/J mice.

Neoplasia 2007 May;9(5):401-5

Department of Surgery, The Alvin J. Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1877981PMC
http://dx.doi.org/10.1593/neo.07160DOI Listing
May 2007

Fine mapping and candidate gene analyses of pulmonary adenoma resistance 1, a major genetic determinant of mouse lung adenoma resistance.

Cancer Res 2007 Mar;67(6):2508-16

Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3157DOI Listing
March 2007

The investigation of electrospun polymer nanofibers as a solid-phase extraction sorbent for the determination of trazodone in human plasma.

Anal Chim Acta 2007 Mar 16;587(1):75-81. Epub 2007 Jan 16.

State Key Laboratory of Molecular and Biomolecular Electronics, Southeast University, Nanjing 210096, PR China.

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http://dx.doi.org/10.1016/j.aca.2007.01.021DOI Listing
March 2007

Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer.

Mol Cancer Res 2006 Dec;4(12):971-81

Department of Surgery, The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-06-0086DOI Listing
December 2006

Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice.

Nat Genet 2006 Aug 23;38(8):888-95. Epub 2006 Jul 23.

Department of Surgery and the Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1038/ng1849DOI Listing
August 2006

Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: role of Ha-ras mutations and use of microarray analysis in identifying potential targets.

Carcinogenesis 2006 Jul 10;27(7):1420-31. Epub 2006 Jan 10.

Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1093/carcin/bgi341DOI Listing
July 2006

p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer.

Mol Cancer Res 2006 Jun;4(6):401-10

Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-06
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http://dx.doi.org/10.1158/1541-7786.MCR-06-0028DOI Listing
June 2006

Organ-specific expression profiles of rat mammary gland, liver, and lung tissues treated with targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide.

Mol Cancer Ther 2006 Apr;5(4):1060-72

Department of Surgery and The Alvin J. Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, 660 South, Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-05-0322DOI Listing
April 2006

A gene expression signature that can predict green tea exposure and chemopreventive efficacy of lung cancer in mice.

Cancer Res 2006 Feb;66(4):1956-63

Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3158DOI Listing
February 2006

Efficacy of polyphenon E, red ginseng, and rapamycin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice.

Neoplasia 2006 Jan;8(1):52-8

Department of Surgery, The Alvin J. Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1593/neo.05652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1584290PMC
January 2006

Efficacy of deguelin and silibinin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice.

Neoplasia 2005 Dec;7(12):1053-7

Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1501176PMC
http://dx.doi.org/10.1593/neo.05532DOI Listing
December 2005

Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53.

Mol Cancer Res 2005 Oct;3(10):563-74

Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, 660 Euclid Avenue, Box 8109, St. Louis, Missouri 63110, USA.

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http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-05
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http://dx.doi.org/10.1158/1541-7786.MCR-05-0144DOI Listing
October 2005

Gene expression profiling of mouse teratocarcinomas uncovers epigenetic changes associated with the transformation of mouse embryonic stem cells.

Neoplasia 2004 Sep-Oct;6(5):490-502

Division of Human Cancer Genetics, The Ohio State University Comprehensive Cancer Center, 420 West 12th Avenue, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1593/neo.04124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1531652PMC
April 2005

Altered gene expression profile in mouse bladder cancers induced by hydroxybutyl(butyl)nitrosamine.

Neoplasia 2004 Sep-Oct;6(5):569-77

Department of Surgery and The Alvin J. Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1593/neo.04223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1531661PMC
April 2005

Tobacco smoke-induced lung tumorigenesis in mutant A/J mice with alterations in K-ras, p53, or Ink4a/Arf.

Oncogene 2005 Apr;24(18):3042-9

Department of Surgery, School of Medicine, Siteman Cancer Center, The Washington University in St Louis, 660 S Euclid Avenue, St Louis, MO, USA.

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http://dx.doi.org/10.1038/sj.onc.1208390DOI Listing
April 2005

Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus.

Oncogene 2005 Mar;24(11):1958-63

Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8109, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1038/sj.onc.1208295DOI Listing
March 2005

Identification of genetic polymorphisms through comparative DNA sequence analysis on the K-ras gene: implications for lung tumor susceptibility.

Exp Lung Res 2005 Mar;31(2):165-77

Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1080/01902140490495543DOI Listing
March 2005

Characterization of two protein-binding sites in the second intron of the mouse K-ras gene.

Exp Lung Res 2005 Mar;31(2):179-92

Department of Pathology, Medical College of Ohio, Toledo, Ohio, USA.

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http://dx.doi.org/10.1080/0190214049049552DOI Listing
March 2005

K-ras mutations in lung tumors from p53 mutant mice exposed to cigarette smoke.

Exp Lung Res 2005 Mar;31(2):271-81

Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1080/0190214059090386DOI Listing
March 2005

Analysis of the Par2 modifier of pulmonary adenoma formation in mice.

Exp Lung Res 2005 Mar;31(2):193-204

Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.

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March 2005

Tumor susceptibility of Rassf1a knockout mice.

Cancer Res 2005 Jan;65(1):92-8

Division of Biology, City of Hope National Medical Center, Duarte, CA 91010, USA.

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January 2005

Budesonide exerts its chemopreventive efficacy during mouse lung tumorigenesis by modulating gene expressions.

Oncogene 2004 Oct;23(46):7746-52

Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1038/sj.onc.1207985DOI Listing
October 2004

Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models.

Oncogene 2004 May;23(21):3841-50

Department of Surgery and The Alvin J Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1038/sj.onc.1207496DOI Listing
May 2004

Chemoprevention of lung cancer in transgenic mice.

Chest 2004 May;125(5 Suppl):144S-7S

Chemoprevention Branch, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1378/chest.125.5_suppl.144sDOI Listing
May 2004

A chemically induced model for squamous cell carcinoma of the lung in mice: histopathology and strain susceptibility.

Cancer Res 2004 Mar;64(5):1647-54

Department of Surgery and the Siteman Cancer Center , Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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March 2004

Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia.

Cancer Res 2004 Mar;64(6):1924-31

Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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March 2004

Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice.

Proc Natl Acad Sci U S A 2003 Oct;100(22):12642-7

Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1073/pnas.2133947100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC240671PMC
October 2003

Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf.

Oncogene 2003 Sep;22(40):6257-65

Department of Surgery and The Alvin J. Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1038/sj.onc.1206630DOI Listing
September 2003

Mice with alterations in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: differential chemopreventive effect of budesonide in wild-type and mutant A/J mice.

Cancer Res 2003 Aug;63(15):4389-95

Department of Surgery, The Alvin J. Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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August 2003

Differential gene expression in chemically induced mouse lung adenomas.

Neoplasia 2003 Jan-Feb;5(1):41-52

Division of Human Cancer Genetics and School of Public Health, The Ohio State University James Cancer Center, Columbus, OH 43210, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1502122PMC
http://dx.doi.org/10.1016/s1476-5586(03)80016-7DOI Listing
July 2003

Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines.

Cancer Res 2003 Jun;63(12):3317-24

Division of Human Cancer Genetics, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43210, USA.

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June 2003

Molecular alterations and lung tumors in p53 mutant mice exposed to cigarette smoke.

Cancer Res 2003 Feb;63(4):793-800

Department of Health Sciences, University of Genoa, I-16132 Genoa, Italy.

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February 2003

LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer.

Oncogene 2003 Feb;22(8):1243-6

Division of Human Cancer genetics, The Ohio Stsate University Comprehensive Cancer Center, 420 West 12th Avenue, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1038/sj.onc.1206192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438910PMC
February 2003

Differentially expressed genes associated with mouse lung tumor progression.

Oncogene 2002 Aug;21(37):5814-21

Division of Human Cancer Genetics, The Ohio State University Comprehensive Cancer Center, 420 West 12th Avenue, Columbus, Ohio, OH 43210, USA.

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http://dx.doi.org/10.1038/sj.onc.1205422DOI Listing
August 2002

A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression.

Oncogene 2002 Aug;21(38):5960-6

Division of Human Cancer Genetics, The Ohio State University Comprehensive Cancer Center, 420 West 12th Avenue, Columbus 43210, USA.

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http://dx.doi.org/10.1038/sj.onc.1205725DOI Listing
August 2002

p53 transgenic mice are highly susceptible to 1, 2-dimethylhydrazine-induced uterine sarcomas.

Cancer Res 2002 Jun;62(11):3024-9

Division of Human Cancer Genetics, The Ohio State University Comprehensive Cancer Center, 514 Medical Research Facility, 420 West 12th Avenue, Columbus, OH 43210, USA.

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June 2002