Publications by authors named "Yi-Feng Yang"

104 Publications

Case Report: BAF-Opathies/SSRIDDs Due to a ACTL6A Variant, Previously Considered to Be Heart-Hand Syndrome.

Front Cardiovasc Med 2021 13;8:708033. Epub 2021 Aug 13.

Department of Cardiovascular Surgery, Clinical Center for Gene Diagnosis and Therapy, The Second Xiangya Hospital of Central South University, Changsha, China.

This study aims to identify genetic lesions in patients with congenital heart disease (CHD) with or without other phenotypes. In this study, over 400 patients were recruited and several novel variants in known causative genes were identified. A Chinese patient clinically diagnosed with HHS (patent ductus arteriosus, persistent left superior vena cava, and congenital absence of left arm radius) was included in the study cohort. Targeted, whole exome, and Sanger sequencing were performed to identify genetic lesions. The effects of the variant on ACTL6A RNA and protein were assessed using bioinformatics analysis. At the start of the study, no mutations in known and candidate causative genes associated with CHD were identified. Seven years later, we noticed craniofacial deformities and identified a heterozygous deletion variant in ACTL6A (NM_004301, c.478_478delT; p.F160Lfs9). Intellectual disability and short stature were identified by a follow-up visit 10 years later. This variant leads to frameshift sequences and a premature termination codon and may affect the features of proteins. According to the nonsense-mediated mRNA decay theory, this variant may induce the decay of ACTL6A mRNA in patients. Our study reported the first ACTL6A variant in a Chinese individual, providing further evidence that ACTL6A is involved in heart and upper limb skeletal and intellectual development, thereby expanding the spectrum of ACTL6A variants. Thus, mutation analysis of the ACTL6A gene should be considered in patients with BAF-opathies or heart-hand syndromes due to potential misdiagnosis. Craniofacial dysmorphisms and intellectual disability are key to distinguishing these two diseases clinically, and attention to developmental delay/intellectual disability and craniofacial deformities will contribute to the diagnosis of BAF-opathies.
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http://dx.doi.org/10.3389/fcvm.2021.708033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414571PMC
August 2021

Midterm Outcomes of Crosslinked Acellular Bovine Jugular Vein Conduit for Right Ventricular Outflow Tract Reconstruction.

Front Pediatr 2021 17;9:725030. Epub 2021 Aug 17.

Clinical Physiology Laboratory, Guangzhou Women and Children's Medical Center, Institute of Pediatrics, Guangzhou Medical University, Guangzhou, China.

Conduits for reconstructing right ventricular outflow tract (RVOT) in children with congenital heart disease have evolved for better durability over the past decades, but conduits failure remains common. We designed decellularized and photooxidatively crosslinked bovine jugular vein conduit (DP-BJVC) and now aim to evaluate the midterm results of DP-BJVC for RVOT reconstruction. Ninety patients (median age: 4.2 years) undergoing RVOT reconstruction using DP-BJVC were prospectively followed for median of 4.7 years (range: 0.2-16.1 years). Kaplan-Meier analysis was used to examine the survival, freedom from conduit explantation and catheter-based reintervention. Risk factors were analyzed with Cox regression analysis. Follow-up was completed in 92% of patients. There were five (5.6%) early deaths. The 10-year survival rate was 85.2%, with palliative procedure at DP-BJVC implantation as the risk factor. The 10-year freedom from conduit explantation and reintervention were 84.4 and 67.3% respectively, with previous cardiac operation as the only risk factor for explantation. Complications during the follow-up included conduit stenosis (peak gradient ≥50 mmHg) in 12 (12.9%), severe regurgitation in 2 (2.4%), and infective endocarditis in 2 (2.4%). The annual increase in gradient was highest in the first year ( = 0.003), but not appreciably afterwards. The echo-measured annulus diameter trends to increase by an average of 0.37 mm per year. Calcification appeared mild in the failed conduits. DP-BJVC provides satisfactory durability and functionality for RVOT reconstruction for children, with low morbidity of stenosis and endocarditis, as well as increase in diameter mildly with age in midterm follow-ups.
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http://dx.doi.org/10.3389/fped.2021.725030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416030PMC
August 2021

Pancreatic Fibrosis (Early Chronic Pancreatitis) as Emerging Diagnosis in Structural Causes of Dyspepsia: Evidence from Endoscopic Ultrasonography and Shear Wave Elastography.

Diagnostics (Basel) 2021 Jul 13;11(7). Epub 2021 Jul 13.

Graduate Institute of Applied Science and Engineering (ASE), College of Science and Engineering, Fu Jen Catholic University, No. 510, Zhongzheng Rd., Xinzhuang Dist., New Taipei City 242062, Taiwan.

A new concept for the diagnosis and management of non-functional dyspepsia in guidelines was lacking in the past decade. Medical advancement has proven pancreatic fibrosis (essential image evidence of early chronic pancreatitis) to be a cause of dyspepsia and related to pancreatic exocrine dysfunction. This study aimed to analyze the clinical picture, biomarker, and percentage of pancreatic fibrosis in the dyspeptic population. A total of 141 consecutive patients were retrospectively enrolled. They were diagnosed with peptic ulcer disease, 9.2% ( = 13); pancreatic fibrosis, 17% ( = 24); pure Helicobacter pylori infection, 19.9% ( = 28); functional dyspepsia, 53.2% ( = 75); and chronic pancreatitis, 0.7% ( = 1). Among those with pancreatic fibrosis, ( = 24), 11 were diagnosed on the basis of a pancreatic acoustic radiation force impulse exceeding 1.4 m/s, and the remaining 13 were diagnosed with early chronic pancreatitis with at least three of the Japanese endoscopic ultrasonography criteria. The anatomic distribution of parenchymal criteria of early chronic pancreatitis was head, 53%; body, 38%; and tail, 9%. There were 17 cases (71%, 17/24) without Helicobacter pylori and whose dyspepsia improved after pancreatic enzyme replacement with a ratio of 82.3% (14/17). Of the 141 cases, 19 received gastric emptying scintigraphy and Western blot analysis of chromogranin-A in duodenal mucosa. Delayed gastric emptying was more common in functional dyspepsia and chromogranin-A was expressed more in pancreatic fibrosis. In conclusion, pancreatic fibrosis (including early chronic pancreatitis) outnumbered peptic ulcer disease in the dyspeptic population and pancreatic enzyme therapy was effective for 82% of cases. In early chronic pancreatitis, pancreatic fibrosis is dominant in the head location, and duodenum mucosa chromogranin-A is a potential biomarker with increased expression in an age-matched manner.
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http://dx.doi.org/10.3390/diagnostics11071252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304562PMC
July 2021

Bandwidth-control orbital-selective delocalization of 4f electrons in epitaxial Ce films.

Nat Commun 2021 May 4;12(1):2520. Epub 2021 May 4.

Center for Correlated Matter and Department of Physics, Zhejiang University, Hangzhou, China.

The 4f-electron delocalization plays a key role in the low-temperature properties of rare-earth metals and intermetallics, and it is normally realized by the Kondo coupling between 4f and conduction electrons. Due to the large Coulomb repulsion of 4f electrons, the bandwidth-control Mott-type delocalization, commonly observed in d-electron systems, is difficult in 4f-electron systems and remains elusive in spectroscopic experiments. Here we demonstrate that the bandwidth-control orbital-selective delocalization of 4f electrons can be realized in epitaxial Ce films by thermal annealing, which results in a metastable surface phase with reduced layer spacing. The quasiparticle bands exhibit large dispersion with exclusive 4f character near [Formula: see text] and extend reasonably far below the Fermi energy, which can be explained from the Mott physics. The experimental quasiparticle dispersion agrees well with density-functional theory calculation and also exhibits unusual temperature dependence, which could arise from the delicate interplay between the bandwidth-control Mott physics and the coexisting Kondo hybridization. Our work opens up the opportunity to study the interaction between two well-known localization-delocalization mechanisms in correlation physics, i.e., Kondo vs Mott, which can be important for a fundamental understanding of 4f-electron systems.
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http://dx.doi.org/10.1038/s41467-021-22710-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096960PMC
May 2021

Bi-allelic BRWD1 variants cause male infertility with asthenoteratozoospermia and likely primary ciliary dyskinesia.

Hum Genet 2021 May 3;140(5):761-773. Epub 2021 Jan 3.

Department of Respiratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.

Genetics-associated asthenoteratozoospermia is often seen in patients with multiple morphological abnormalities of the sperm flagella (MMAF). Although 24 causative genes have been identified, these explain only approximately half of patients with MMAF. Since sperm flagella and motile cilia (especially respiratory cilia) have similar axonemal structures, many patients with MMAF also exhibit respiratory symptoms, such as recurrent airway infection, chronic sinusitis, and bronchiectasis, which are frequently associated with primary ciliary dyskinesia (PCD), another recessive disorder. Here, exome sequencing was conducted to evaluate the genetic cause in 53 patients with MMAF and classic PCD/PCD-like symptoms. Two homozygous missense variants and a compound-heterozygous variant in the BRWD1 gene were identified in three unrelated individuals. BRWD1 staining was detected in the whole flagella and respiratory cilia of normal controls but was absent in BRWD1-mutated individuals. Transmission electron microscopy and immunostaining demonstrated that BRWD1 deficiency in human affected respiratory cilia and sperm flagella differently, as the absence of outer and inner dynein arms in sperm flagellum and respiratory cilia, while with a decreased number and outer doublet microtubule defects of respiratory cilia. To our knowledge, this is the first report of a BRWD1-variant-related disease in humans, manifesting as an autosomal recessive form of MMAF and PCD/PCD-like symptoms. Our data provide a basis for further exploring the molecular mechanism of BRWD1 gene during spermatogenesis and ciliogenesis.
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http://dx.doi.org/10.1007/s00439-020-02241-4DOI Listing
May 2021

A Novel Nonsense Variant Causes Dextrocardia and Congenital Heart Disease in a Han Chinese Patient.

Front Cardiovasc Med 2020 9;7:582350. Epub 2020 Nov 9.

Clinical Center for Gene Diagnosis and Therapy, Department of Cardiovascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, China.

The position and morphology of human internal organs are asymmetrically distributed along the left-right axis. Aberrant left-right patterning in the developing embryo can lead to a series of congenital laterality defects, such as dextrocardia and heterotaxy syndrome. Laterality defects are a genetic condition; however, pathogenic genetic lesions are found in only one-fifth of patients. In this study, whole-exome sequencing was conducted for 78 patients with laterality defects. We identified a novel stopgain variant in (c.G496T; p.G166) in a Chinese patient with mirror-image dextrocardia. This variant caused a truncated mRNA containing only the signal peptide and propeptide, while the coding sequence of matrix metalloproteinase-21 was almost entirely absent. To the best of our knowledge, this novel variant is the first homozygous stopgain variant identified in dextrocardia patients, and the first variant found in East Asia. Our findings expand the spectrum of variants and provide support for the critical role of during left-right patterning in the Han Chinese population.
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http://dx.doi.org/10.3389/fcvm.2020.582350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680847PMC
November 2020

Many-Body Resonance in a Correlated Topological Kagome Antiferromagnet.

Phys Rev Lett 2020 Jul;125(4):046401

Laboratory for Topological Quantum Matter and Advanced Spectroscopy, Department of Physics, Princeton University, Princeton 08544, New Jersey, USA.

We use scanning tunneling microscopy to elucidate the atomically resolved electronic structure in the strongly correlated kagome Weyl antiferromagnet Mn_{3}Sn. In stark contrast to its broad single-particle electronic structure, we observe a pronounced resonance with a Fano line shape at the Fermi level resembling the many-body Kondo resonance. We find that this resonance does not arise from the step edges or atomic impurities but the intrinsic kagome lattice. Moreover, the resonance is robust against the perturbation of a vector magnetic field, but broadens substantially with increasing temperature, signaling strongly interacting physics. We show that this resonance can be understood as the result of geometrical frustration and strong correlation based on the kagome lattice Hubbard model. Our results point to the emergent many-body resonance behavior in a topological kagome magnet.
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http://dx.doi.org/10.1103/PhysRevLett.125.046401DOI Listing
July 2020

The impact of atrial fibrillation on outcomes in patients undergoing radical prostatectomy.

World J Urol 2021 May 4;39(5):1509-1519. Epub 2020 Jul 4.

Department of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1 Dongdan Dahua Road, Dongcheng District, Beijing, 100730, China.

Purpose: To assess the role of atrial fibrillation (AF) on complicating inpatient outcomes of radical prostatectomy (RP).

Materials And Methods: We identified patients treated with RP during 2012-2014 within National Inpatient Sample (NIS) database. Length of stay, cost of hospitalization, and in-hospital complications were compared between patients with or without diagnosis of AF. Propensity score matching methods and multivariable regression analysis were used to adjust for potential confounders and a trend analysis was conducted.

Results: Patients with AF had a significantly longer hospital stay (coefficient 0.19, 95% CI 0.09-0.29, P < 0.001) and higher cost (coefficient 0.10, 95% CI 0.06-0.15, P < 0.001). Post-operative cardiac complications were significantly higher for patients with AF (OR 16.38, 95% CI 7.72-34.74, P < 0.001), while no differences were found in other complications between the two groups. Similar results were shown in propensity score matching methods. The cardiac complications after laparoscopic RP (OR: 37.71, 95% CI 1.85-768.73, P = 0.018) and open RP (OR: 16.78, 95% CI 1.41-199.51, P = 0.026) were significantly higher than robot-assisted RP (RARP) in patients with AF. The results of trend study indicated that postoperative cardiac complication rates showed a trend of decreasing year by year while the prevalence of AF was rising.

Conclusions: Perioperative AF is associated with increased cardiac complications, longer hospital stay and higher cost in PCa patients undergoing RP. RARP may be a preferred choice for patients with AF. Attention should be paid to this special patient population. Reasonable pre-operative risk stratification and standardized management should be done to decrease perioperative complications.
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http://dx.doi.org/10.1007/s00345-020-03337-2DOI Listing
May 2021

Universal Behavior of the Thermal Hall Conductivity.

Phys Rev Lett 2020 May;124(18):186602

Kavli Institute for Theoretical Sciences and CAS Center for Topological Quantum Computation, University of Chinese Academy of Sciences, Beijing 100190, China.

We report theoretical and experimental analyses of the thermal Hall conductivity in correlated systems. For both fermionic and bosonic excitations with nontrivial topology, we show that at "intermediate" temperatures, the thermal Hall conductivity exhibits an unexpected universal scaling with a simple exponential form. At low temperatures, it behaves differently and reflects the spectral properties of underlying excitations. Our predictions are examined as examples in two prototype compounds, the quantum paraelectric SrTiO_{3} and the spin-liquid compound RuCl_{3}. The experimental data can be largely covered by our proposed minimal phenomenological model independent of microscopic details, revealing dominant bosonic contributions in SrTiO_{3} and gapped fermionic excitations in RuCl_{3}. Our work establishes a phenomenological link between microscopic models and experimental data and provides a unified basis for analyzing the thermal Hall conductivity in correlated systems over a wide temperature region.
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http://dx.doi.org/10.1103/PhysRevLett.124.186602DOI Listing
May 2020

Mutant CARD10 in a family with progressive immunodeficiency and autoimmunity.

Cell Mol Immunol 2020 07 1;17(7):782-784. Epub 2020 Apr 1.

Department of Respiratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

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http://dx.doi.org/10.1038/s41423-020-0423-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331643PMC
July 2020

Hybridization Dynamics in CeCoIn_{5} Revealed by Ultrafast Optical Spectroscopy.

Phys Rev Lett 2020 Feb;124(5):057404

State Key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China, Chengdu 611731, China.

We investigate the quasiparticle dynamics in the prototypical heavy fermion CeCoIn_{5} using ultrafast optical pump-probe spectroscopy. Our results indicate that this material system undergoes hybridization fluctuations before the establishment of heavy electron coherence, as the temperature decreases from ∼120  K (T^{†}) to ∼55  K (T^{*}). We reveal that the anomalous coherent phonon softening and damping reduction below T^{*} are directly associated with the emergence of collective hybridization. We also discover a distinct collective mode with an energy of ∼8  meV, which may be experimental evidence of the predicted unconventional density wave. Our findings provide important information for understanding the hybridization dynamics in heavy fermion systems.
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http://dx.doi.org/10.1103/PhysRevLett.124.057404DOI Listing
February 2020

Quasi-Two-Dimensional Fermi Surfaces and Unitary Spin-Triplet Pairing in the Heavy Fermion Superconductor UTe_{2}.

Phys Rev Lett 2019 Nov;123(21):217002

Beijing National Laboratory for Condensed Matter Physics and Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.

We report first-principles and strongly correlated calculations of the newly discovered heavy fermion superconductor UTe_{2}. Our analyses reveal three key aspects of its magnetic, electronic, and superconducting properties that include (i) a two-leg ladder-type structure with strong magnetic frustrations, which might explain the absence of long-range orders and the observed magnetic and transport anisotropy, (ii) quasi-two-dimensional Fermi surfaces composed of two separate electron and hole cylinders with similar nesting properties as in UGe_{2}, which may potentially promote magnetic fluctuations and help to enhance the spin-triplet pairing, and (iii) a unitary spin-triplet pairing state of strong spin-orbit coupling at zero field, with point nodes presumably on the heavier hole Fermi surface along the k_{x} direction, in contrast to the previous belief of nonunitary pairing. Our proposed scenario is in excellent agreement with latest thermal conductivity measurement and provides a basis for understanding the peculiar magnetic and superconducting properties of UTe_{2}.
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http://dx.doi.org/10.1103/PhysRevLett.123.217002DOI Listing
November 2019

Adenine decreases hypertrophic effects through interleukin-18 receptor.

Chin J Physiol 2019 Jul-Aug;62(4):139-147

Graduate Institute of Applied Science and Engineering; Department and Institute of Life Science, Fu-Jen Catholic University, Taipei, Taiwan.

Cardiac hypertrophy is the main cause of heart failure. Levels of circulating interleukin-18 (IL-18) have been reported to increase in congestive heart disease and cardiac hypertrophy. Relationships among IL-18 levels, IL-18 receptor (IL-18R) expression, and cardiac hypertrophy remain unclear. IL-18 can induce cardiac hypertrophy in cardiomyoblasts. We also studied IL-18R messenger RNA (mRNA) and protein expression through quantitative-polymerase chain reaction and Western blotting. Furthermore, we treated cardiomyoblasts with adenine, gold nanoparticles (AuNPs), and inhibitors to analyze the morphology and identify signaling pathways involved in cardiac hypertrophy. Moreover, we studied the effects of IL-18R small interfering RNA (siRNA) on signaling pathways through Western blotting. The mRNA expression of IL-18R in H9c2 cardiomyoblasts, which was induced by IL-18, increased significantly after 8 h, and the protein level increased significantly after 15 h. Morphological examination of H9c2 cardiomyoblasts showed that cell volume and cell diameter decreased after adenine pretreatment. Both p38 MAPK and PI3 kinase are biomarkers in the pathway correlated with cardiac hypertrophy. After treatment with inhibitors SB203580 and LY294002, the levels of p38 MAPK and PI3 kinase, respectively, decreased along with cell size and IL-18R expression. Treatment with adenine, but not AuNPs, reduced the levels of phosphorylated p38 and PI3 kinase expression more effectively than did treatment with the respective inhibitors alone. IL-18R siRNA significantly reduced cell size but not PI3 kinase expression and phosphorylation of p38 MAPK. However, adenine treatment reduced PI3 kinase expression after treatment with IL-18R siRNA. In this study, IL-18 induced cardiomyoblast hypertrophy through IL-18R upregulation, which was found to be related to p38 MAPK and PI3 kinase signaling. Adenine, but not AuNPs, showed antihypertrophic effects possibly because of decreased levels of signaling.
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http://dx.doi.org/10.4103/CJP.CJP_18_19DOI Listing
October 2019

Sesamin Promotes Osteoblastic Differentiation and Protects Rats from Osteoporosis.

Med Sci Monit 2019 Jul 17;25:5312-5320. Epub 2019 Jul 17.

Department of Orthopedics, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China (mainland).

BACKGROUND Osteoporosis is a common osteopathy, resulting in fractures, especially in elder people. Sesamin has many pharmacological effects, including supplying calcium. However, how sesamin might prevent osteoporosis is still under study. MATERIAL AND METHODS Bone marrow stromal cells (BMSCs) extracted from rat femur were induced for osteoblastic differentiation. Cell proliferation, alkaline phosphatase (ALP), osterix (OSX), SRY-box 9 (SOX9), runt-related transcription factor 2 (RUNX2), osteocalcin (OCN), ß-catenin, low density lipoprotein receptor-related protein 5 (LRP5), and glycogen synthase kinase-3ß (GSK-3ß) levels in BMSCs were detected in the presence or absence of sesamin (1 μM or 10 µM). In addition, FH535 (1 μM) was used to silence Wnt/ß-catenin in vitro. Ovariectomized (OVX) rats were established and intragastrically administrated sesamin (80 mg/kg), and then the rat bones were analyzed by micro-computed tomography. Osteocalcin and collagen type I were measured in the rat femurs. RESULTS Sesamin had no influence on BMSC proliferation. Higher sesamin concentration promoted Wnt/ß-catenin activity and enhanced more expressions of ALP, OSX, SOX9, RUNX2, and OCN, gradually and significantly (P<0.05). Silencing Wnt/ß-catenin weakened the enhancement on RUNX2 and OCN expression. Sesamin (80 mg/kg) promoted bone structure in ovariectomized rats, and significantly enhanced osteocalcin and collage type I expression (P<0.05). CONCLUSIONS Sesamin promoted osteoblastic differentiation of rat BMSCs by regulating the Wnt/ß-catenin pathway, and improved rat bone structure. Sesamin could have therapeutic and preventive effects on osteoporosis.
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http://dx.doi.org/10.12659/MSM.915529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659468PMC
July 2019

Unconventional Antiferromagnetic Quantum Critical Point in Ba(Fe_{0.97}Cr_{0.03})_{2}(As_{1-x}P_{x})_{2}.

Phys Rev Lett 2019 Jan;122(3):037001

Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.

We have systematically studied physical properties of Ba(Fe_{0.97}Cr_{0.03})_{2}(As_{1-x}P_{x})_{2}, where superconductivity in BaFe_{2}(As_{1-x}P_{x})_{2} is fully suppressed by just 3% of Cr substitution of Fe. A quantum critical point is revealed at x∼0.42, where non-Fermi-liquid behaviors similar to those in BaFe_{2}(As_{1-x}P_{x})_{2} are observed. Neutron diffraction and inelastic neutron scattering measurements suggest that the quantum critical point is associated with the antiferromagnetic order, which is not of conventional spin-density-wave type as evidenced by the ω/T scaling of spin excitations. On the other hand, no divergence of low-temperature nematic susceptibility is observed when x is decreased to 0.42 from higher doping level, demonstrating that there are no nematic quantum critical fluctuations. Our results suggest that non-Fermi-liquid behaviors in iron-based superconductors can be solely resulted from the antiferromagnetic quantum critical fluctuations, which cast doubts on the role of nematic fluctuations played in the normal-state properties in iron-based superconductors.
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http://dx.doi.org/10.1103/PhysRevLett.122.037001DOI Listing
January 2019

Expression and characterization of recombinant human lactoferrin in edible alga Chlamydomonas reinhardtii.

Biosci Biotechnol Biochem 2019 May 23;83(5):851-859. Epub 2019 Jan 23.

a College of Life Sciences , Nankai University , Tianjin , China.

Lactoferrin (LF) is a naturally occurring iron-binding glycoprotein with a variety of biological functions. It has increasing demand every year and huge market potential. In this study, we explored the feasibility of expressing human LF (hLF) in edible algae C. reinhardtii. A codon-optimized hLF gene was synthesized, inserted into pCAMBIA-1301C and transformed into C. reinhardtii SP strain. In total, 7 hLF-expressing clones were selected with clone 121 exhibiting the highest expression level. The hLF-containing algal extract significantly inhibited the growth of bacteria such as Escherichia coli and Klebsiella variicola. During acute toxicity experiment no acute toxicity was detected, especially on changes of the body weight and histopathology of organs. The recombinant hLF possessed a similar or modestly reduced stability compared to commercial hLF standard. Our data indicated that expression of hLF in C. reinhardtii is feasible and paved a way to commercial production of lactoferrin using edible Chlamydomonas expression system. Abbreviations: atrazine chlorohydrolase gene (atzA); bovine serum albumin (BSA); human LF (hLF); lactoferrin (LF); Luria-Bertani (LB); quantitative reverse transcriptase PCR (qRT-PCR) ; SDS polyacrylamide gel electrophoresis (SDS-PAGE); Tris-acetate phosphate (TAP); western blotting (WB).
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http://dx.doi.org/10.1080/09168451.2019.1569498DOI Listing
May 2019

High-Temperature Ferrimagnetic Half Metallicity with Wide Spin-up Energy Gap in NaCuFeOsO.

Inorg Chem 2019 Jan 11;58(1):320-326. Epub 2018 Dec 11.

Beijing National Laboratory for Condensed Matter Physics, Institute of Physics , Chinese Academy of Sciences , Beijing 100190 , China.

A new oxide NaCuFeOsO is synthesized using high pressure and temperature conditions. The Rietveld structural analysis shows that the compound possesses both A- and B-site ordered quadruple perovskite structure in Pn3̅ symmetry. The valence states of transition metals are confirmed to be Cu/Fe/Os. The three transition metals all take part in magnetic interactions and generate strong Cu(↑)Fe(↑)Os(↓) ferrimagnetic superexchange interactions with a high Curie temperature about 380 K. Electrical transport measurements suggest its half-metallic properties. The first-principles theoretical calculations demonstrate that the compound has a spin-down conducting band and a spin-up insulating band with a wide energy gap.
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http://dx.doi.org/10.1021/acs.inorgchem.8b02404DOI Listing
January 2019

[Nitrogen Removal of Double-bacteria-layer System via PN/A Process].

Huan Jing Ke Xue 2018 Aug;39(8):3767-3774

College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China.

Nitrification and anaerobic ammonia oxidation (ANAMMOX) sludge was acclimated via SBR and MBR reactors respectively, both of which were embedded with microbial immobilization technology and spliced together to construct a PN/A double-bacteria-layer system. A short-term experiment proved that ammonia-oxidizing bacteria (AOB) and ANAMMOX bacteria in the system played dominant roles separately in different stages, which maintained the acid-base balance and achieved efficient removal of NH-N (98.8%). A long-term experiment showed that the PN/A double-bacteria-layer system improved the utilization of dissolved oxygen (DO) and enhanced the stability and nitrogen removal efficiency, with limited dissolved oxygen. The nitrogen removal efficiency of the PN/A double-bacteria-layer system remained stable at~80% when the influent NH-N was 200 mg·L or 400 mg·L in the presence of 1.0 mg·L DO, whereas those of the control group were only 58.1% and 61.4%, respectively. When influent NH-N and DO were 400 mg·L and 3.0 mg·L, respectively, the PN/A double-bacteria-layer system achieved a nitrogen removal efficiency, nitrogen loading rate (NLR), and nitrogen removal rate (NRR) of 87.9%, 0.4 kg·(m·d), and 12.8 mg·(g·h), respectively.
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http://dx.doi.org/10.13227/j.hjkx.201801029DOI Listing
August 2018

Gap Symmetry of the Heavy Fermion Superconductor CeCu_{2}Si_{2} at Ambient Pressure.

Phys Rev Lett 2018 May;120(21):217001

Beijing National Laboratory for Condensed Matter Physics and Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.

Recent observations of two nodeless gaps in superconducting CeCu_{2}Si_{2} have raised intensive debates on its exact gap symmetry, while a satisfactory theoretical basis is still lacking. Here we propose a phenomenological approach to calculate the superconducting gap functions, taking into consideration both the realistic Fermi surface topology and the intra- and interband quantum critical scatterings. Our calculations yield a nodeless s^{±}-wave solution in the presence of strong interband pairing interaction, in good agreement with experiments. This provides a possible basis for understanding the superconducting gap symmetry of CeCu_{2}Si_{2} at ambient pressure and indicates the potential importance of multiple Fermi surfaces and interband pairing interaction in understanding heavy fermion superconductivity.
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http://dx.doi.org/10.1103/PhysRevLett.120.217001DOI Listing
May 2018

BaVSe: a novel compound with spin chains.

J Phys Condens Matter 2018 May 13;30(21):214001. Epub 2018 Apr 13.

Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, People's Republic of China. School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100190, People's Republic of China.

In this work, a novel compound BaVSe with one-dimensional (1D) spin chains was synthesized under high-pressure and high-temperature conditions. It was systematically characterized via structural, magnetic, thermodynamic and transport measurements. BaVSe crystallizes into a hexagonal structure with a space group of P-6c2 (188) and the lattice constants of a  =  b  =  9.5745(7) Å and c  =  18.7814(4) Å. The crystal structure consists of face-sharing octahedral VSe chains along c axis, which are trimeric and arranged in a triangular lattice in ab-plane. BaVSe is a semiconductor and undergoes complex magnetic transitions. In the zero-field-cooled (ZFC) process with magnetic field of 10 Oe, BaVSe sequentially undergoes ferrimagnetic and spin cluster glass transition at 2.5 K and 3.3 K, respectively. When the magnetic field exceeds 50 Oe, only the ferrimagnetic transition can be observed. Above the transition temperature, the specific heat contains a significant magnetic contribution that is proportional to T . The calculation suggests that the nearest neighbor (NN) intra-chain antiferromagnetic exchange J is much larger than the next nearest neighbor (NNN) intra-chain ferromagnetic exchange J . Therefore, BaVSe can be regarded as an effective ferromagnetic chains with effective spin-1/2 by the formation of the V(2) V(1) V(2) cluster.
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http://dx.doi.org/10.1088/1361-648X/aabdffDOI Listing
May 2018

AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling.

Nat Microbiol 2018 03 29;3(3):302-309. Epub 2018 Jan 29.

Scientific Research Center, Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, China.

Zika virus (ZIKV) is associated with neonatal microcephaly and Guillain-Barré syndrome. While progress has been made in understanding the causal link between ZIKV infection and microcephaly, the life cycle and pathogenesis of ZIKV are less well understood. In particular, there are conflicting reports on the role of AXL, a TAM family kinase receptor that was initially described as the entry receptor for ZIKV. Here, we show that while genetic ablation of AXL protected primary human astrocytes and astrocytoma cell lines from ZIKV infection, AXL knockout did not block the entry of ZIKV. We found, instead, that the presence of AXL attenuated the ZIKV-induced activation of type I interferon (IFN) signalling genes, including several type I IFNs and IFN-stimulating genes. Knocking out type I IFN receptor α chain (IFNAR1) restored the vulnerability of AXL knockout astrocytes to ZIKV infection. Further experiments suggested that AXL regulates the expression of SOCS1, a known type I IFN signalling suppressor, in a STAT1/STAT2-dependent manner. Collectively, our results demonstrate that AXL is unlikely to function as an entry receptor for ZIKV and may instead promote ZIKV infection in human astrocytes by antagonizing type I IFN signalling.
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http://dx.doi.org/10.1038/s41564-017-0092-4DOI Listing
March 2018

Orbital-dependent charge dynamics in MnP revealed by optical study.

Sci Rep 2017 10 27;7(1):14178. Epub 2017 Oct 27.

Beijing National Laboratory for Condensed Matter Physics and Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, China.

Unconventional superconductivity often emerges at the border of long-range magnetic orders. Understanding the low-energy charge dynamics may provide crucial information on the formation of superconductivity. Here we report the unpolarized/polarized optical conductivity study of high quality MnP single crystals at ambient pressure. Our data reveal two types of charge carriers with very different lifetimes. In combination with the first-principles calculations, we show that the short-lifetime carriers have flat Fermi sheets which become gapped in the helimagnetic phase, causing a dramatic change in the low-frequency optical spectra, while the long-lifetime carriers are anisotropic three-dimensional like which are little affected by the magnetic transitions and provide major contributions to the transport properties. This orbital-dependent charge dynamics originates from the special crystal structure of MnP and may have an influence on the unconventional superconductivity and its interplay with helimagnetism at high pressures.
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http://dx.doi.org/10.1038/s41598-017-14648-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660257PMC
October 2017

Unified Phase Diagram for Iron-Based Superconductors.

Phys Rev Lett 2017 Oct 13;119(15):157001. Epub 2017 Oct 13.

Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.

High-temperature superconductivity is closely adjacent to a long-range antiferromagnet, which is called a parent compound. In cuprates, all parent compounds are alike and carrier doping leads to superconductivity, so a unified phase diagram can be drawn. However, the properties of parent compounds for iron-based superconductors show significant diversity and both carrier and isovalent dopings can cause superconductivity, which casts doubt on the idea that there exists a unified phase diagram for them. Here we show that the ordered moments in a variety of iron pnictides are inversely proportional to the effective Curie constants of their nematic susceptibility. This unexpected scaling behavior suggests that the magnetic ground states of iron pnictides can be achieved by tuning the strength of nematic fluctuations. Therefore, a unified phase diagram can be established where superconductivity emerges from a hypothetical parent compound with a large ordered moment but weak nematic fluctuations, which suggests that iron-based superconductors are strongly correlated electron systems.
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http://dx.doi.org/10.1103/PhysRevLett.119.157001DOI Listing
October 2017

Glucagon-like peptide receptor agonists attenuate advanced glycation end products-induced inflammation in rat mesangial cells.

BMC Pharmacol Toxicol 2017 10 24;18(1):67. Epub 2017 Oct 24.

Division of Nephrology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.

Background: Hyperglycemia-induced advanced glycation end products (AGEs) and receptor for AGEs (RAGE) production play major roles in progression of diabetic nephropathy. Anti-RAGE effect of peroxisome proliferator-activated receptor-delta (PPARδ) agonists was shown in previous studies. PPARδ agonists also stimulate glucagon-like peptide-1 (GLP-1) secretion from human intestinal cells.

Methods: In this study, the individual and synergic anti-inflammatory effects of GLP-1 receptor (exendin-4) and PPARδ (L-165,041) agonists in AGE-treated rat mesangial cells (RMC) were investigated.

Results: The results showed both exendin-4 and L-165,041 significantly attenuated AGE-induced IL-6 and TNF-α production, RAGE expression, and cell death in RMC. Similar anti-inflammatory potency was seen between 0.3 nM exendin-4 and 1 μM L-165,041. Synergic effect of exendin-4 and L-165,041 was shown in inhibiting cytokines production, but not in inhibiting RAGE expression or cell death.

Conclusions: These results suggest that both GLP-1 receptor and PPARδ agonists have anti-inflammatory effect on AGE-treated rat mesangial cells.
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http://dx.doi.org/10.1186/s40360-017-0172-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655807PMC
October 2017

Hybridization oscillation in the one-dimensional Kondo-Heisenberg model with Kondo holes.

Sci Rep 2017 09 20;7(1):11924. Epub 2017 Sep 20.

Beijing National Laboratory for Condensed Matter Physics and Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, China.

We use the density matrix renormalization group method to study the properties of the one-dimensional Kondo-Heisenberg model doped with Kondo holes. We find that the perturbation of the Kondo holes to the local hybridization exhibits spatial oscillation pattern and its amplitude decays exponentially with distance away from the Kondo hole sites. The hybridization oscillation is correlated with both the charge density oscillation of the conduction electrons and the oscillation in the correlation function of the Heisenberg spins. In particular, we find that the oscillation wavelength for intermediate Kondo couplings is given by the Fermi wavevector of the large Fermi surface even before it is formed. This suggests that heavy electrons responsible for the oscillation are already present in this regime and start to accumulate around the to-be-formed large Fermi surface in the Brillouin zone.
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http://dx.doi.org/10.1038/s41598-017-12240-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607262PMC
September 2017

Universal linear-temperature resistivity: possible quantum diffusion transport in strongly correlated superconductors.

Sci Rep 2017 08 25;7(1):9469. Epub 2017 Aug 25.

Beijing National Laboratory for Condensed Matter Physics and Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, China.

The strongly correlated electron fluids in high temperature cuprate superconductors demonstrate an anomalous linear temperature (T) dependent resistivity behavior, which persists to a wide temperature range without exhibiting saturation. As cooling down, those electron fluids lose the resistivity and condense into the superfluid. However, the origin of the linear-T resistivity behavior and its relationship to the strongly correlated superconductivity remain a mystery. Here we report a universal relation [Formula: see text], which bridges the slope of the linear-T-dependent resistivity (dρ/dT) to the London penetration depth λ at zero temperature among cuprate superconductor BiSrCaCuO and heavy fermion superconductors CeCoIn, where μ is vacuum permeability, k is the Boltzmann constant and ħ is the reduced Planck constant. We extend this scaling relation to different systems and found that it holds for other cuprate, pnictide and heavy fermion superconductors as well, regardless of the significant differences in the strength of electronic correlations, transport directions, and doping levels. Our analysis suggests that the scaling relation in strongly correlated superconductors could be described as a hydrodynamic diffusive transport, with the diffusion coefficient (D) approaching the quantum limit D ~ ħ/m*, where m* is the quasi-particle effective mass.
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http://dx.doi.org/10.1038/s41598-017-09792-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573385PMC
August 2017

Zika virus infects renal proximal tubular epithelial cells with prolonged persistency and cytopathic effects.

Emerg Microbes Infect 2017 Aug 23;6(8):e77. Epub 2017 Aug 23.

Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.

Zika virus (ZIKV) infection can cause fetal developmental abnormalities and Guillain-Barré syndrome in adults. Although progress has been made in understanding the link between ZIKV infection and microcephaly, the pathology of ZIKV, particularly the viral reservoirs in human, remains poorly understood. Several studies have shown that compared to serum samples, patients' urine samples often have a longer duration of ZIKV persistency and higher viral load. This finding suggests that an independent viral reservoir may exist in the human urinary system. Despite the clinical observations, the host cells of ZIKV in the human urinary system are poorly characterized. In this study, we demonstrate that ZIKV can infect renal proximal tubular epithelial cells (RPTEpiCs) in immunodeficient mice in vivo and in both immortalized and primary human renal proximal tubular epithelial cells (hRPTEpiCs) in vitro. Importantly, ZIKV infection in mouse kidneys caused caspase-3-mediated apoptosis of renal cells. Similarly, in vitro infection of immortalized and primary hRPTEpiCs resulted in notable cytopathic effects. Consistent with the clinical observations, we found that ZIKV infection can persist with prolonged duration in hRPTEpiCs. RNA-Seq analyses of infected hRPTEpiCs revealed a large number of transcriptional changes in response to ZIKV infection, including type I interferon signaling genes and anti-viral response genes. Our results suggest that hRPTEpiCs are a potential reservoir of ZIKV in the human urinary system, providing a possible explanation for the prolonged persistency of ZIKV in patients' urine.
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http://dx.doi.org/10.1038/emi.2017.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583673PMC
August 2017

An effective combination of whole-exome sequencing and runs of homozygosity for the diagnosis of primary ciliary dyskinesia in consanguineous families.

Sci Rep 2017 08 11;7(1):7905. Epub 2017 Aug 11.

Central South University Center for Clinical Gene Diagnosis and Treatment, the Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

Primary ciliary dyskinesia (PCD) is clinically characterized by neonatal respiratory distress, chronic sinusitis, bronchiectasis and infertility, and situs inversus in 50% of the patients. PCD is a result of mutations in genes encoding proteins involved in ciliary function, and is primarily inherited in an autosomal recessive fashion. Diagnosis of PCD is often a challenging task due to its high clinical and genetic heterogeneities. In the present study, we attempted to use whole-exome sequencing (WES) combined with runs of homozygosity (ROH) approaches to identify the genetic defects in four Chinese consanguineous families with clinical PCD. We successfully identified three recently acknowledged PCD genes: DYX1C1, CCNO and ARMC4, and one well-characterized PCD gene, DNAI1. Our study provides compelling evidence that WES in combination with ROH analysis is an efficient diagnostic tool for identifying genetic causes of PCD in consanguineous families. Furthermore, our work expands the genetic mutation spectrum in PCD, and provides the additional tools to better serve the counseling of the families with PCD.
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http://dx.doi.org/10.1038/s41598-017-08510-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554225PMC
August 2017

A Novel Homozygous SACS Mutation Identified by Whole-Exome Sequencing in a Consanguineous Family with Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay.

Cytogenet Genome Res 2017 29;152(1):16-21. Epub 2017 Jun 29.

Clinical Center for Gene Diagnosis and Therapy of State Key Laboratory of Medical Genetics, The Second Xiangya Hospital of Central South University, Changsha, China.

Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a hereditary neurological disorder mostly manifested with a classical triad: progressive early-onset cerebellar ataxia, lower limb pyramidal signs, and peripheral neuropathy. We employed whole-exome sequencing and bioinformatics to identify the genetic cause in an ARSACS patient from a consanguineous family. Based on whole-exome sequences of the patient and her healthy parents, a novel homozygous deletion variant (NM_014363: c.9495_9508del; p.F3166Tfs*9) in the SACS gene was identified in the patient. This frameshift mutation is predicted to generate a truncated sacsin protein, which results in the loss of the C-terminal 1,406 amino acids. Our study provides a potential genetic diagnosis for the patient and expands the spectrum of SACS mutations.
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http://dx.doi.org/10.1159/000477428DOI Listing
September 2017

Quantum critical scaling and fluctuations in Kondo lattice materials.

Proc Natl Acad Sci U S A 2017 06 30;114(24):6250-6255. Epub 2017 May 30.

Cavendish Laboratory, Department of Physics, Cambridge University, Cambridge CB3 0HE, United Kingdom.

We propose a phenomenological framework for three classes of Kondo lattice materials that incorporates the interplay between the fluctuations associated with the antiferromagnetic quantum critical point and those produced by the hybridization quantum critical point that marks the end of local moment behavior. We show that these fluctuations give rise to two distinct regions of quantum critical scaling: Hybridization fluctuations are responsible for the logarithmic scaling in the density of states of the heavy electron Kondo liquid that emerges below the coherence temperature [Formula: see text], whereas the unconventional power law scaling in the resistivity that emerges at lower temperatures below [Formula: see text] may reflect the combined effects of hybridization and antiferromagnetic quantum critical fluctuations. Our framework is supported by experimental measurements on CeCoIn, CeRhIn, and other heavy electron materials.
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http://dx.doi.org/10.1073/pnas.1703172114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474795PMC
June 2017
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