Publications

Intermittent hypoxia-induced cardiomyopathy and its prevention by Nrf2 and metallothionein.
Free Radic Biol Med 2017 Nov 2;112:224-239. Epub 2017 Aug 2.
Pediatric Research Institute, the Department of Pediatrics of University of Louisville, Louisville 40202, USA; Chinese-American Research Institute for Diabetic Complication, Wenzhou Medical College, Wenzhou 325035, China; Diabetes and Obesity Center, University of Louisville, Louisville, KY 40202, USA. Electronic address:

From the Cover: Alcohol Inhibition of the Enzymatic Activity of Glyceraldehyde 3-Phosphate Dehydrogenase Impairs Cardiac Glucose Utilization, Contributing to Alcoholic Cardiomyopathy.
Toxicol Sci 2017 Oct;159(2):392-401
Chinese-American Research Institute for Diabetic Complications & School of Pharmaceutical Sciences, Wenzhou Medical University, Chashan University-Town, Wenzhou, Zhejiang, China.


Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts.
Diabetes 2017 Oct 27. Epub 2017 Oct 27.
Chinese-American Research Institute for Diabetic Complications, School of Pharmaceutical Sciences & the First Affiliated Hospital at the Wenzhou Medical University, Wenzhou, China.

Construction of an alkaline phosphatase-specific two-photon probe and its imaging application in living cells and tissues.
Biomaterials 2017 Sep 23;140:220-229. Epub 2017 Jun 23.
Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China. Electronic address:

A reaction-based near-infrared fluorescent sensor for Cu2+ detection in aqueous buffer and its application in living cells and tissues imaging.
Biosens Bioelectron 2017 Aug 24;94:24-29. Epub 2017 Feb 24.
Department of Physics and Materials Science, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, PR China. Electronic address:

Sitagliptin-mediated preservation of endothelial progenitor cell function via augmenting autophagy enhances ischaemic angiogenesis in diabetes.
J Cell Mol Med 2017 Aug 10. Epub 2017 Aug 10.
Chinese-American Research Institute for Diabetic Complications, School of Pharmaceutical Sciences, School of Nursing at the Wenzhou Medical University, Wenzhou, China.

Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability.
Cell Rep 2017 Aug;20(7):1717-1728
Department of Biochemistry & Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA. Electronic address:


Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats.
World J Gastroenterol 2017 Jun;23(21):3805-3814
Yi Tan, Jane Kim, Jing Cheng, Madeleine Ong, Wei-Guo Lao, Xing-Liang Jin, Yi-Guang Lin, Linda Xiao, Xue-Qiong Zhu, Xian-Qin Qu, School of Medical and Molecular Biosciences, University of Technology Sydney, NSW 2007, Australia.

μ3-Chlorido-μ2-chlorido-(μ3-pyrrolidine-1-carbo-dithio-ato-κ4S:S,S':S')tris-[(tri-ethyl-phosphane-κP)copper(I)]: crystal structure and Hirshfeld surface analysis.
Acta Crystallogr E Crystallogr Commun 2017 May 18;73(Pt 5):720-725. Epub 2017 Apr 18.
Research Centre for Crystalline Materials, School of Science and Technology, Sunway University, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia.


Elevating CXCR7 Improves Angiogenic Function of EPCs via Akt/GSK-3β/Fyn-Mediated Nrf2 Activation in Diabetic Limb Ischemia.
Circ Res 2017 Mar 30;120(5):e7-e23. Epub 2017 Jan 30.
From the Chinese-American Research Institute for Diabetic Complications, School of Pharmaceutical Sciences & School of Nursing at the Wenzhou Medical University, Wenzhou, China (X.D., X.Y., Jun Chen, X.L., Y.T.); School of Biomedicine, Chengdu Medical College, China (X.D., K.P.); Department of Pediatrics, Children's Hospital Research Institute, School of Medicine (X.D., J.Z., Jing Chen, Jun Chen, P.N.E., Y.T.), Department of Surgery (Y.L.), Department of Medicine (M.T.B., M.A.N., D.J.C.), Division of Endocrinology, Department of Pediatrics, Wendy L. Novak Diabetes Care Center (K.A.W.), and Diabetes and Obesity Center (D.J.C.), University of Louisville, KY; Departments of Geriatrics, the First Hospital of Jilin University, Changchun, China (Y.W.); and Division of Cardiovascular Disease, University of Alabama at Birmingham (G.R.).

Reaction-Based Off-On Near-infrared Fluorescent Probe for Imaging Alkaline Phosphatase Activity in Living Cells and Mice.
ACS Appl Mater Interfaces 2017 Mar 15;9(8):6796-6803. Epub 2017 Feb 15.
Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong , Shenzhen 518057, P. R. China.

Alpha2,3-sialyltransferase III knockdown sensitized ovarian cancer cells to cisplatin-induced apoptosis.
Biochem Biophys Res Commun 2017 Jan 19;482(4):758-763. Epub 2016 Nov 19.
Central Laboratory of the First Affiliated Hospital of Jinan University, 510630, Guangzhou, China; School of Pharmacy, Wenzhou Medical University, 325035, Wenzhou, China. Electronic address:

Endoplasmic reticulum stress-induced neuronal inflammatory response and apoptosis likely plays a key role in the development of diabetic encephalopathy.
Oncotarget 2016 Nov;7(48):78455-78472
Chinese-American Research Institute for Diabetic Complications, School of Pharmaceutical Science, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Zinc deficiency exacerbates while zinc supplement attenuates cardiac hypertrophy in high-fat diet-induced obese mice through modulating p38 MAPK-dependent signaling.
Toxicol Lett 2016 Sep 21;258:134-146. Epub 2016 Jun 21.
Department of Pediatrics, University of Louisville, Louisville, KY, USA; Wendy Novak Diabetes Care Center, University of Louisville, Louisville, KY, USA. Electronic address:

From the Cover: Zinc Deficiency Worsens and Supplementation Prevents High-Fat Diet Induced Vascular Inflammation, Oxidative Stress, and Pathological Remodeling.
Toxicol Sci 2016 Sep 30;153(1):124-36. Epub 2016 Jun 30.
Chinese-American Research Institute for Diabetic Complications, School of Pharmaceutical Sciences and School of Nursing, Wenzhou Medical University, Wenzhou 325035, China Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202.

Corrigendum to ''Metallothionein plays a prominent role in the prevention of diabetic nephropathy by sulforaphane via up-regulation of Nrf2'' [Free Radic. Biol. Med. 89 (2015) 431-42].
Free Radic Biol Med 2016 Aug 22;97:621. Epub 2016 Jul 22.
Kosair Children's Hospital Research Institute at the Department of Pediatrics, Wendy L. Novak Diabetes Care Center, University of Louisville, Louisville, KY 40202, USA; Chinese-American Research Institute for Diabetic Complications, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325200, China. Electronic address:

C66 ameliorates diabetic nephropathy in mice by both upregulating NRF2 function via increase in miR-200a and inhibiting miR-21.
Diabetologia 2016 Jul 26;59(7):1558-1568. Epub 2016 Apr 26.
Kosair Children's Hospital Research Institute at the Department of Pediatrics, Wendy L. Novak Diabetes Care Center, University of Louisville, 570 S Preston St, Baxter I., Louisville, KY, 40202, USA.

Fenofibrate increases cardiac autophagy via FGF21/SIRT1 and prevents fibrosis and inflammation in the hearts of Type 1 diabetic mice.
Clin Sci (Lond) 2016 Apr 21;130(8):625-41. Epub 2016 Jan 21.
The Chinese-American Research Institute for Diabetic Complications, the Wenzhou Medical University, Wenzhou 325035, China Kosair Children Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville 40202, KY, U.S.A. Departments of Medicine and Pharmacology & Toxicology, University of Louisville, Louisville 40202, KY, U.S.A.

Up-regulation of Nrf2 is involved in FGF21-mediated fenofibrate protection against type 1 diabetic nephropathy.
Free Radic Biol Med 2016 Apr 2;93:94-109. Epub 2016 Feb 2.
The Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou 325035, China; Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA; The Third Affiliated Hospital of the Wenzhou Medical University, Ruian 325200, China; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USA. Electronic address:

Epidemiological trends and characteristics of Japanese encephalitis changed based on the vaccination program between 1960 and 2013 in Guangxi Zhuang Autonomous Region, southern China.
Int J Infect Dis 2016 Apr 10;45:135-8. Epub 2016 Mar 10.
Section of Epidemiology and Statistics, School of Public Health, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. Electronic address:

Genistein-loaded nanoparticles of star-shaped diblock copolymer mannitol-core PLGA-TPGS for the treatment of liver cancer.
Mater Sci Eng C Mater Biol Appl 2016 Feb 30;59:792-800. Epub 2015 Oct 30.
Clinical Laboratory, Huai'an First People's Hospital, Nanjing Medical University, Huaian 223003, China. Electronic address:

Metallothionein plays a prominent role in the prevention of diabetic nephropathy by sulforaphane via up-regulation of Nrf2.
Free Radic Biol Med 2015 Dec 28;89:431-42. Epub 2015 Sep 28.
Kosair Children's Hospital Research Institute at the Department of Pediatrics, Wendy L. Novak Diabetes Care Center, University of Louisville, Louisville, KY, USA, 40202; Chinese-American Research Institute for Diabetic Complications, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China, 325200. Electronic address:


Minireview: Roles of Fibroblast Growth Factors 19 and 21 in Metabolic Regulation and Chronic Diseases.
Mol Endocrinol 2015 Oct 26;29(10):1400-13. Epub 2015 Aug 26.
Ruian Center of the Chinese-American Research Institute for Diabetic Complications (F.Z., L.Y., X.Lin, P.C., L.H., X.Lu, Y.T., H.Y., L.C., C.Z.), Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 325200; Chinese-American Research Institute for Diabetic Complications (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., L.C., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; School of Pharmaceutical Sciences (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; and Department of Pediatrics (Y.T., L.C.), University of Louisville, Louisville, Kentucky 40202.

New insights into the function of Cullin 3 in trophoblast invasion and migration.
Reproduction 2015 Aug 28;150(2):139-49. Epub 2015 May 28.
State Key Laboratory of Reproductive BiologyInstitute of Zoology, Chinese Academy of Sciences, Beijing 100101, People's Republic of ChinaDepartment of ObstetricsBeijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, People's Republic of ChinaKey Laboratory of Longevity and Ageing-related DiseasesMinistry of Education, Guangxi Medical University, Nanning 530021, People's Republic of ChinaLaboratory Animal CenterChongqing Medical University, Chongqing 400016, People's Republic of ChinaSchool of Life SciencesUniversity of Chinese Academy of Sciences, Beijing 100101, People's Republic of China

Fibroblast growth factor 21 protects the heart from apoptosis in a diabetic mouse model via extracellular signal-regulated kinase 1/2-dependent signalling pathway.
Diabetologia 2015 Aug 4;58(8):1937-48. Epub 2015 Jun 4.
Chinese-American Research Institute for Diabetic Complication, School of Pharmaceutical Sciences, Wenzhou Medical University, Chashan University-Town, Wenzhou, 325035, People's Republic of China.

Novel Multifunctional Organic-Inorganic Hybrid Curing Agent with High Flame-Retardant Efficiency for Epoxy Resin.
ACS Appl Mater Interfaces 2015 Aug 6;7(32):17919-28. Epub 2015 Aug 6.
†Center for Degradable and Flame-Retardant Polymeric Materials, College of Chemistry, State Key Laboratory of Polymer Materials Engineering, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), Sichuan University, Chengdu 610064, China.

Additive protection by LDR and FGF21 treatment against diabetic nephropathy in type 2 diabetes model.
Am J Physiol Endocrinol Metab 2015 Jul 12;309(1):E45-54. Epub 2015 May 12.
Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China; Ruian Center of Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China; Kosair Children's Hospital Research Institute, Department of Pediatrics, the University of Louisville School of Medicine, Louisville, Kentucky.

The protective effect of FGF21 on diabetes-induced male germ cell apoptosis is associated with up-regulated testicular AKT and AMPK/Sirt1/PGC-1α signaling.
Endocrinology 2015 Mar 5;156(3):1156-70. Epub 2015 Jan 5.
The First Hospital of Jilin University (X.J., Z.Z.) and Key Laboratory of Pathobiology (Y.X.), Ministry of Education, Jilin University, Changchun 130021, China; Kosair Children's Hospital Research Institute at the Department of Pediatrics (X.J., J.C., Z.Z., Y.T., Y.X., L.C.), and Departments of Medicine (W.F.) and Pharmacology and Toxicology (Y.T., W.F., M.S., L.C.), University of Louisville, Louisville 40202; and Nursing School of Wenzhou Medical University (J.C.) and The Chinese-American Research Institute for Diabetic Complications (C.Z., Y.T., M.S., L.C.), Wenzhou Medical University, Wenzhou 325035, China.


Metallothionein deletion exacerbates intermittent hypoxia-induced renal injury in mice.
Toxicol Lett 2015 Jan 15;232(2):340-8. Epub 2014 Nov 15.
Kosair Children's Hospital Research Institute, Department of Pediatrics, The University of Louisville, Louisville, KY, USA; Department of Pharmacology and Toxicology, The University of Louisville School of Medicine, Louisville, KY, USA. Electronic address:


Magnolia bioactive constituent 4-O-methylhonokiol prevents the impairment of cardiac insulin signaling and the cardiac pathogenesis in high-fat diet-induced obese mice.
Int J Biol Sci 2015 5;11(8):879-91. Epub 2015 Jun 5.
2. The Chinese-American Research Institute for Diabetic Complications and the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China ; 3. Kosair Children's Hospital Research Institute, Department of Pediatrics of University of Louisville, Louisville, KY 40202.

IL-10 Protects Neurites in Oxygen-Glucose-Deprived Cortical Neurons through the PI3K/Akt Pathway.
PLoS One 2015 14;10(9):e0136959. Epub 2015 Sep 14.
Department of Neurology, The Affiliated Union Hospital, Fujian Medical University, Fuzhou, Fujian, People's Republic of China; Institute of Cerebral Vascular Disease of Fujian Province, Fuzhou, Fujian, People's Republic of China; Department of Rehabilitation, The Affiliated Union Hospital, Fujian Medical University, Fuzhou, Fujian, People's Republic of China.

Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases.
J Diabetes Res 2016 9;2016:1540267. Epub 2016 May 9.
The Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou 325035, China; Ruian Center of the Chinese-American Research Institute for Diabetic Complications, The Third Affiliated Hospital, Wenzhou Medical University, Wenzhou 325200, China; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.

Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2.
Oxid Med Cell Longev 2017 16;2017:5374897. Epub 2017 Jan 16.
Pediatric Research Institute, Department of Pediatrics, Wendy L. Novak Diabetes Care Center, University of Louisville, 570 S Preston St, Louisville, KY 40202, USA; Chinese-American Research Institute for Diabetic Complications, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.


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