Publications by authors named "Yi Shao"

355 Publications

Risk factors for esophageal squamous cell carcinoma and its histological precursor lesions in China: a multicenter cross-sectional study.

BMC Cancer 2021 Sep 16;21(1):1034. Epub 2021 Sep 16.

Department of Endoscopy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Background: Despite research efforts, the causative factors that contribute to esophageal squamous cell carcinoma (ESCC) in high-risk areas have not yet been understood. In this study, we, therefore, aimed to describe the risk factors associated with ESCC and its precursor lesions.

Methods: We performed an endoscopic examination of 44,857 individuals aged 40-69 years from five high incidence regions of China in 2017-2018. Participants were classified as 4 groups of normal control, esophagitis, low-grade intraepithelial neoplasia (LGIN) and high-grade intraepithelial neoplasia/esophageal squamous cell carcinoma (HGIN/ESCC) using an unconditional logistic regression determine risk factors.

Results: We identified 4890 esophagitis, 1874 LGIN and 437 HGIN/ESCC cases. Crude odds ratios (ORs) and adjusted odds ratios were calculated using unconditional logistic regression. Drinking well and surface water, salty diet, and positive family history of cancer were the common risk factors for esophagitis, LGIN and HGIN/ESCC. History of chronic hepatitis/cirrhosis was the greatest risk factor of esophagitis (adjusted OR 2.96, 95%CI 2.52-3.47) and HGIN/ESCC (adjusted OR 1.91, 95%CI 1.03-3.22). Pesticide exposure (adjusted OR 1.20, 95%CI 1.05-1.37) was essential risk factor of LGIN.

Conclusions: Among individuals aged 40-69 years in high incidence regions of upper gastrointestinal cancer, the results provided important epidemiological evidence for the prevention of different precancerous lesions of ESCC.
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http://dx.doi.org/10.1186/s12885-021-08764-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444572PMC
September 2021

Alternation of brain intrinsic activity in patients with hypertensive retinopathy: a resting-state fMRI study.

Aging (Albany NY) 2021 09 13;13(17):21659-21670. Epub 2021 Sep 13.

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center, Nanchang 330006, Jiangxi, People's Republic of China.

Objective: To investigate the changes of amplitude of low-frequency fluctuation (ALFF) in brain regions of patients with hypertensive retinopathy by using resting-state functional magnetic resonance imaging (rs-fMRI) and change in the relationship of ALFF value with potential emotional and psychological changes.

Methods: Thirty-one patients with hypertensive retinopathy (HR) (16 men and 15 women) and 31 healthy controls (HCs; 16 men and 15 women) matched for age, sex, and weight were enrolled in the research. The changes in mean ALFF values could reflect brain activity between HR patients and HCs. We used the independent samples t-test to evaluate different demographic and general information between the two groups. Two-sample t-test was used to detect differences of mean ALFF values in the brain region between the two groups using the same software.

Results: The ALFF values in the brain areas of HR and HCs were different. HR patients had lower ALFF value in the left medial superior frontal gyrus and left middle frontal gyrus than the HCs. The higher ALFF values were found in the cerebellum (left inferior and right superior lobes, vermis) and left inferior temporal gyrus of the HR patients than the controls.

Conclusion: Our findings showed fluctuations in ALFF values in the HR patients' brain regions. ALFF values reflect over or reduced activity in brain regions. Abnormal ALFF values in these brain areas can predict early HR development, preventing the malignant transformation of hypertensive microangiopathy.
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http://dx.doi.org/10.18632/aging.203510DOI Listing
September 2021

A retrospective analysis of endocrinopathy manifestations in 136 Chinese patients with POEMS syndrome.

Neuro Endocrinol Lett 2021 Sep 10;42(5):292-296. Epub 2021 Sep 10.

Department of Endocrinology, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.

Objective: POEMS syndrome is a rare multisystemic disease, with a wide spectrum of clinical endocrinopathies. Patients with POEMS syndrome may present with one or more hormone disorders during the disease course, but such phenomenon has usually been underestimated. In this report, we analyzed the prevalence and clinical characteristics of endocrine abnormalities in a large Chinese cohort with POEMS syndrome.

Methods: This retrospective review was performed in patients with a definite diagnosis of POEMS syndrome who were hospitalized in our hospital between January 2000 and January 2020. The clinical data about endocrine abnormalities were extracted from their medical records and analyzed.

Results: This study comprised 136 patients (95 male, 41 female) with a median age of 48(40-56) years old. Endocrine abnormalities were frequent (127 cases, 93.38%) in patients with POEMS syndrome. The prevalence of single endocrinopathy and multiple endocrinopathies were 12.60% (16/127 cases) and 87.40% (111/127), respectively. The most frequent endocrinopathy was hypogonadism (98/136, 72.06%), followed by hypothyroidism (83/136, 61.03%), hypocalcemia (50/136, 36.76%), hyperprolactinemia (47/136, 34.56%), abnormal glucose metabolism (41/136, 30.15%) and adrenal insufficiency (41/136, 30.15%). In patients with multiple endocrinopathies, the prevalence of 2, 3, 4, 5, and 6 kinds of endocrine axes involved were 29.92% (38/127), 30.71% (39/127), 17.32% (22/127), 7.09% (9/127) and 2.36% (3/127), respectively. Such hormone disorders cause complex clinical presentations, including overt or subclinical situations.

Conclusion: Endocrinopathy manifestations in POEMS syndrome are more frequent, and its clinical complicacy should be emphasized in differential diagnosis. For patients with a definite diagnosis of POEMS syndrome, an early and thorough endocrine evaluation should be performed.
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September 2021

Blindfolded adults' use of geometric cues in haptic-based relocation.

Psychon Bull Rev 2021 Sep 10. Epub 2021 Sep 10.

Department of Psychology, Oklahoma City University, Norman, OK, USA.

Non-visual information is important for navigation in limited visibility conditions. We designed a haptic-based relocation task to examine blindfolded adults' use of geometric cues. Forty-eight participants learned to locate a corner in a parallelogram frame. They were then tested in different transformed frames: (a) a reverse-parallelogram, in which locations predicted by original length information and angle information conflicted, (b) a rectangle, which retained only length information, and (c) a rhombus, which retained only angle information. Results show that access to the environment's geometry through haptic modality is sufficient for relocation. However, adults' performances in the current task were different from that in visual tasks in previous findings. First, compared to previous findings in visual-based tasks, length information lost its priority. Approximately half of the participants relied on angle information in the conflict test and the other half relied on length. Second, though participants encoded both length and angle information in the learning phase, only one cue was relied on after the conflict test. Finally, though participants encoded the target location successfully, they failed to represent the global shape of the environment. We attribute adults' different performances in haptic-based and visual-based tasks to the high cognitive demands in encoding and using haptic spatial cues, especially length information.
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http://dx.doi.org/10.3758/s13423-021-01994-xDOI Listing
September 2021

Congenital and Perinatal Tuberculosis.

Neoreviews 2021 Sep;22(9):e600-e605

Division of Pediatric Infectious Disease, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern Medical Center, Chicago, IL.

This review discusses the recent literature (2006-2020) about the epidemiology, clinical presentation, diagnosis, and management of infants with congenital or perinatal tuberculosis (TB). While the incidence of childhood TB is declining in the United States and worldwide, many case reports describe how clinical suspicion for neonatal TB is raised only if an ill-appearing neonate does not improve with broad-spectrum antibiotics. Furthermore, the delay in initiating appropriate anti-TB therapy often results in the need for significant cardiopulmonary support and/or an increase in mortality. This review summarizes important clinical indications in the maternal and newborn history, the evaluation of an infant with possible TB exposure, and step-by-step recommendations for the treatment and follow-up of infants with TB.
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http://dx.doi.org/10.1542/neo.22-9-e600DOI Listing
September 2021

Serum markers change for intraocular metastasis in renal cell carcinoma.

Biosci Rep 2021 Sep;41(9)

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.

Objective: Renal cell carcinoma is prone to early metastasis. In general, intraocular metastasis (IOM) is not common. In the present study, we studied the relationship between different biochemical indicators and the occurrence of IOM in renal cancer patients, and identified the potential risk factors.

Methods: A retrospective analysis of the clinical data of 214 patients with renal cell carcinoma from October 2001 to August 2016 was carried out. The difference and correlation of various indicators between the two groups with or without IOM was analyzed, and binary logistic regression analysis was used to explore the risk factors of IOM in renal cancer patients. The diagnostic value of each independent related factor was calculated according to the receiver operating curve (ROC).

Results: The level of neuron-specific enolase (NSE) in renal cell carcinoma patients with IOM was significantly higher than that in patients without IOM (P<0.05). There was no significant difference in alkaline phosphatase (ALP), hemoglobin (Hb), serum calcium concentration, α fetoprotein (AFP), carcinoembryonic antigen (CEA), CA-125 etc. between IOM group and non-IOM (NIOM) group (P>0.05). Binary logistic regression analysis showed that NSE was an independent risk factor for IOM in renal cell carcinoma patients (P<0.05). ROC curve shows that the factor has high accuracy in predicting IOM, and the area under the curve (AUC) is 0.774. The cut-off value of NSE was 49.5 U/l, the sensitivity was 72.2% and the specificity was 80.1%.

Conclusion: NSE concentration is a risk factor for IOM in patients with renal cell cancer. If the concentration of NSE in the patient's body is ≥49.5 U/l, disease monitoring and eye scans should be strengthened.
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http://dx.doi.org/10.1042/BSR20203116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438111PMC
September 2021

The effect of enzymes on the in vitro degradation behavior of Mg alloy wires in simulated gastric fluid and intestinal fluid.

Bioact Mater 2022 Jan 12;7:217-226. Epub 2021 Jun 12.

School of Materials Science and Engineering, Southeast University, Jiangning, Nanjing 211189, Jiangsu, China.

With an upsurge of biodegradable metal implants, the research and application of Mg alloys in the gastrointestinal environment of the digestive tract have been of great interest. Digestive enzymes, mainly pepsin in the stomach and pancreatin in the small intestine, are widespread in the gastrointestinal tract, but their effect on the degradation of Mg alloys has not been well understood. In this study, we investigated the impacts of pepsin and pancreatin on the degradation of Mg-2Zn alloy wires. The results showed that the pepsin and pancreatin had completely different even the opposite effects on the degradation of Mg, although they both affected the degradation product layer. The degradation rate of Mg wire declined with the addition of pepsin in simulated gastric fluid (SGF) but rose with the addition of pancreatin in simulated intestinal fluid (SIF). The opposite trends in degradation rate also resulted in completely different degradation morphologies in wires surface, where the pitting corrosion in SGF was inhibited because of the physical barrier effect of pepsin adsorption. In contrast, the adsorption of pancreatin affected the integrity of magnesium hydrogen phosphate film, causing a relatively uneven degraded surface. These results may help us to understand the role of different digestive enzymes in the degradation of magnesium and facilitate the development and clinical application of magnesium alloy implanted devices for the digestive tract.
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http://dx.doi.org/10.1016/j.bioactmat.2021.05.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379480PMC
January 2022

Author Correction: Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study.

Sci Rep 2021 Aug 30;11(1):17653. Epub 2021 Aug 30.

Department of Ophthalmology and Radiology, Jiangxi Center of Natural Ocular Disease Clinical Research Center, The First Affiliated Hospital of Nanchang University, No 17, YongWaiZheng Street, DongHu District, Nanchang, 330006, Jiangxi, People's Republic of China.

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http://dx.doi.org/10.1038/s41598-021-97182-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405611PMC
August 2021

Separation of geometric and featural information in children's spatial representation: Evidence from a model selection task.

J Exp Child Psychol 2021 Aug 23;213:105272. Epub 2021 Aug 23.

Department of Psychology, Oklahoma City University, Oklahoma City, OK 73106, USA.

Previous studies in spatial reorientation have found that young children rely mainly on geometric shapes for reorientation and sometimes ignore features in the environment. Theoretical interpretations of children's reorientation performance are usually attributed to children's spatial representation of their surrounding environments. The geometric module theory states that featural information is represented separately from geometric shape in young children's reorientation, whereas the adaptive combination model depicts an integral representation. Reorientation tasks, however, require the recognition of a specific location, and thus how the whole environment is represented remains unknown. The current study, using a model selection task, explored young children's representation of the whole surrounding environment. A total of 75 children aged 3-5 years participated in the study. In each trial, children observed a large enclosure and were then asked to choose the corresponding model from two small models. The geometric shapes of the enclosure (rectangle vs. rhombus) and the types of distractors (shape distraction vs. feature position distraction) varied. Results showed that all three age groups performed above the chance level in the shape distraction conditions. Children had more difficulty with the feature position distraction conditions than with the shape distraction conditions. When the distractor shared the feature but at an inappropriate position, children's performance was significantly poorer, especially in the rhombic enclosure. The results provide evidence that young children may represent featural cues separately from geometric shapes.
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http://dx.doi.org/10.1016/j.jecp.2021.105272DOI Listing
August 2021

Risk of incident heart failure in individuals with early-onset type 2 diabetes.

J Clin Endocrinol Metab 2021 Aug 20. Epub 2021 Aug 20.

Diabetes Center, Admiralty Medical Center, Singapore.

Context: Early-onset diabetes has been associated with unfavourable cardiovascular risk but data on heart failure (HF) in this subpopulation are scarce.

Objective: To study the risk of, and risk factors for incident HF in individuals with early- onset type 2 diabetes.

Design, Participant And Setting: 606 individuals with type 2 diabetes diagnosed before 40 years old (early-onset) and 1258 counterparts with diabetes diagnosed between 41 to 65 years old (usual-onset) with no HF history were followed for a median of 7.1 years in a regional hospital.

Main Outcome Measure: Incident HF by European Cardiology Society criteria.

Results: 62 and 108 HF events were identified in early- and usual- onset group (1.55 and 1.29 per 100 patient- years), respectively. As compared to usual-onset counterparts, individuals with early-onset diabetes had 1.20 (95% CI 0.88-1.63, P=0.26) folds unadjusted and 1.91 (95% CI 1.37-2.66, P<0.001) folds age- adjusted hazards for incident HF. Adjustment for traditional cardio-metabolic risk factors only moderately mitigated the hazards (adjusted HR 1.69, 95% CI 1.19-2.40, P=0.003). However, additional adjustment for eGFR and albuminuria markedly attenuated the association of early-onset age with incident HF (adjusted HR 1.24, 95% CI 0.87-1.77, P=0.24). Noteworthy, a long diabetes duration was not significantly associated with HF risk after accounting for kidney measures.

Conclusion: Individuals with early- onset diabetes have at least the same absolute risk and 2-fold age- adjusted relative risk for incident HF. Excess cardio-renal risk factors but not a long diabetes duration are main drivers for HF development in this diabetic population.
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http://dx.doi.org/10.1210/clinem/dgab620DOI Listing
August 2021

White Matter Hyperintensities of Bilateral Lenticular Putamen in Patients with Proliferative Diabetic Retinopathy: A Voxel-based Morphometric Study.

Diabetes Metab Syndr Obes 2021 12;14:3653-3665. Epub 2021 Aug 12.

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center, Nanchang, Jiangxi, 330006, People's Republic of China.

Objective: To explore the changes in gray matter volume (GMV) and white matter volume (WMV) in proliferative diabetic retinopathy (PDR) patients using voxel-based morphometry (VBM).

Participants And Methods: In total, 15 patients (10 males, 5 females) with PDR were enrolled to the patient group and 15 healthy controls (10 males, 5 females) to the control group, matched for age, sex, handedness, and education status. All individuals underwent voxel-based morphometry scans. GMV and WMV were compared between the two groups.

Results: GMV in bilateral superior temporal gyrus, sixth area of left cerebellum, left middle temporal gyrus, left orbital inferior frontal gyrus and left middle cingulum gyrus and WMV in left thalamus and left precuneus were significantly lower in patients than controls (<0.01). Conversely, WMV was significantly higher in bilateral lenticular putamen of patients than controls (<0.01).

Conclusion: Abnormal GMV and WMV in many specific areas of the cerebrum provide new insights for exploration of the occurrence and development of DR and its pathophysiology.
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http://dx.doi.org/10.2147/DMSO.S321270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366956PMC
August 2021

Brain Functional Connectivity Changes in Patients with Acute Eye Pain: A Resting-State Functional Magnetic Resonance Imaging (fMRI) Study.

Med Sci Monit 2021 Aug 13;27:e930588. Epub 2021 Aug 13.

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center,, Nanchang, Jiangxi, China (mainland).

BACKGROUND By using functional magnetic resonance imaging (fMRI), we aimed to study the changes in potential brain function network activity in patients with acute eye pain. Also, by using the voxel-wise degree centrality (DC) method, we aimed to explore the relationship between spontaneous brain activity and the clinical features of patients with acute eye pain. MATERIAL AND METHODS A total of 15 patients with acute eye pain (5 women and 10 men; EP group) and 15 healthy controls (5 women and 10 men; HC group), were scanned by fMRI. The DC method was used to evaluate changes in spontaneous brain activity. Receiver operating characteristic (ROC) curves were analyzed, and Pearson correlation analysis was used to study the relationship between DC values and clinical manifestations in different regions of brain. RESULTS The area of the left limbic lobe showed a reduction in DC value in patients in the EP group. DC values were elevated in the left cerebellum posterior lobe, left inferior parietal lobule, left inferior temporal gyrus, left precuneus, and right cerebellum posterior lobe in the EP group. The visual analog scale value of the eyes in the EP group was negatively correlated with the left limbic lobe signal value and positively correlated with the left inferior parietal lobule signal value. Further, the scores of the hospital anxiety and depression scale and DC value of the left limbic lobe were negatively correlated. CONCLUSIONS Compared with the HC group, patients with acute eye pain had abnormal patterns of intrinsic brain activity in different brain regions, which may help reveal the potential neural mechanisms involved in eye pain.
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http://dx.doi.org/10.12659/MSM.930588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369943PMC
August 2021

Investigation of changes in activity and function in acute unilateral open globe injury-associated brain regions based on percent amplitude of fluctuation method: a resting-state functional MRI study.

Acta Radiol 2021 Aug 12:2841851211034035. Epub 2021 Aug 12.

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center, Nanchang, Jiangxi, PR China.

Background: Open globe injury (OGI) is a serious condition that can lead to visual impairment and lifelong sequelae, brain activity of some brain regions would change in patients with OGI.

Purpose: To evaluate changes in brain activity associated with unilateral OGI by resting-state functional magnetic resonance imaging (rs-fMRI) and analysis of percentage amplitude of fluctuation (PerAF).

Material And Methods: A total of 22 patients with OGI (12 men, 10 women) and 22 healthy controls (HCs) matched for sex, age, and body weight were enrolled. All patients underwent rs-fMRI scans. Brain activity in the relevant brain regions was assessed with the PerAF method. The ability of PerAF to distinguish patients with OGI from HCs was assessed by receiver operating characteristic (ROC) curve analysis. We also examined the relationship between Hospital Anxiety and Depression Scale (HADS) scores and PerAF signals by Pearson's correlation analysis.

Results: PerAF values in amygdala_R and Frontal_Inf_Orb_L/Frontal_Inf_Oper_L were increased whereas that in Cerebellum Anterior Lobe/Cerebelum_8_L was decreased in patients with OGI compared to HCs. The areas under the ROC curve showed that these brain regions could distinguish between patients with OGI and HCs. The PerAF value of amygdala_R was positively correlated with HADS scores.

Conclusion: Changes in PerAF in the amygdala_R, Frontal_inferior_Orb_L/Frontal_Inf_Oper_L, and Cerebellum Anterior Lobe/Cerebelum_8_L in patients with OGI may be related to an increased risk of developing psychiatric disorders such as anxiety and depression. PerAF can be used to investigate the neural basis of complications associated with OGI and monitor disease progression.
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http://dx.doi.org/10.1177/02841851211034035DOI Listing
August 2021

Characteristics of mouse intestinal microbiota during acute liver injury and repair following 50% partial hepatectomy.

Exp Ther Med 2021 Sep 5;22(3):953. Epub 2021 Jul 5.

Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.

Dysbiosis of the gut microbiota has important roles in various diseases and pathological states of the host. However, the changes of the gut microbiota during partial hepatectomy (PH)-induced acute liver injury have so far remained elusive. The present study investigated the gut microbiome and its related pathways following PH-induced acute liver injury. A total of 50 male C57/BL6 mice were divided into a normal control (NC), sham-operation and liver resection (LR) group (50% PH). Samples were collected at 3 and 14 days post-operation to obtain specimens for the Sham3, Sham14, LR3 and LR14 groups (10 mice/group). Specimens of NC group (n=10) were obtained at the same time as those of Sham3 group. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined using an automatic chemical analyzer and the gut microbiota was assessed by 16S ribosomal RNA gene sequencing of small intestinal contents. The serum levels of ALT and AST in the LR3 group were significantly increased, while those in the LR14 group were decreased again to near-normal levels. In the LR3 group, the operational taxonomic units, species richness (Chao1) and species diversity (Shannon and Simpson indices) were decreased, although without any significant difference. Furthermore, in the LR3 group, significant Cyanobacteria enrichment and Fusobacteria depletion compared with the NC and Sham3 groups was observed, while in the LR14 group, a significant depletion of the abundance of Verrucomicrobia, Chloroflexi and Deferribacteres compared to the LR3 group was obtained. The abundance of Firmicutes was increased in the LR3 group and decreased again in the LR14 group. However, the abundance of Bacteroidetes and Actinobacteria decreased in the LR3 group and increased again in the LR14 group. The alterations of the gut microbiota at the genus level were also revealed, as significant increases in , , , UCG-005 and and a sharp decrease in and were caused by acute liver injury. Furthermore, functional metagenome prediction was performed by Phylogenetic Investigation of Communities by Reconstruction of Unobserved States based on the Greengenes database, revealing alterations in signal transduction, transcription and cell motility, as well as metabolism of amino acids, lipids, glucose, cofactors and terpenoids, and xenobiotics pathways. An improved understanding of the structural and functional changes of the gut microbiota following 50% PH-induced acute liver injury and repair may provide novel strategies for the recovery of hosts undergoing hepatectomy.
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http://dx.doi.org/10.3892/etm.2021.10385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290421PMC
September 2021

Risk Factors and Their Diagnostic Values for Ocular Metastases in Gastric Adenocarcinoma.

Cancer Manag Res 2021 23;13:5835-5843. Epub 2021 Jul 23.

Department of Geriatric Medicine and Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People's Republic of China.

Objective: Gastric adenocarcinoma originates from the glands in the superficial layer or mucosa of the stomach. It is prone to metastases, of which ocular metastasis (OM) is rare, but once it occurs the disease is considered more serious. The aim of this study was to investigate the risk factors for OM in gastric adenocarcinoma.

Methods: Patients with gastric adenocarcinoma were recruited to this study between June 2003 and July 2019. Demographic data and serological indicators (SI) were compared between patients with and without OM, and binary logistic regression was used to explore whether the relevant SI may be risk factors for OM of gastric adenocarcinoma. Receiver operating characteristic (ROC) curves were used to analyze different SIs for OM in gastric cancer patients.

Results: Chi-square tests showed significant between-groups difference in gender composition (P < 0.05), but not in age or histological grade (P > 0.05). -test results showed that low-density lipoprotein (LDL) and carbohydrate antigen-724 (CA724) were significantly higher in patients with than without OM (P < 0.05). Binary logistic regression analysis showed that LDL was an independent risk factor for OM (P < 0.001). ROC curve analysis showed that the areas under the curves (AUC) for LDL and CA724 were 0.903 and 0.913 respectively, with higher AUC for combined LDL and CA724 (0.934; P < 0.001).

Conclusion: LDL and CA724 have value as predictors for OM in patients with gastric adenocarcinoma, with higher predictive value when these factors are combined.
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http://dx.doi.org/10.2147/CMAR.S311474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315769PMC
July 2021

Vitrectomy alone or Vitrectomy Combined with Scleral Buckle in the Management of Giant Retinal Tears.

J Coll Physicians Surg Pak 2021 Aug;31(8):953-958

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, China.

The aim of this study was to compare as to which treatment achieves better outcomes in the management of giant retinal tears (GRTs) - pars plana vitrectomy (PPV) alone or combined with scleral buckle (SB)? The Web of Science, PubMed, and Cochrane Library databases were searched from January 1, 1950 to October 1, 2020. Pooled odds ratios (ORs), 95% confidence intervals (CIs), heterogeneity, and publication bias were determined with Review Manager software. PPV combined with SB significantly decreased the risk of recurrent retinal detachment (RRD, OR = 0.39, 95% CI = 0.20-0.77, I2 = 35%, p = 0.006) in GRT management compared with PPV alone. However, the final anatomical success (OR = 0.74, 95% CI = 0.23-2.39, I2 = 0%, p = 0.61), final visual acuity (OR = 1.11, 95% CI = 0.48-2.58, I2=13%, p = 0.81), and risk factors of GRT ≥180° (OR = 0.43, 95% CI = 0.15-1.22, I2 = 0%, p = 0.11) were not significantly different between the two approaches. According to the final anatomical success, final visual acuity, and risk factors of GRT ≥180°, there were no significant differences between PPV combined with SB and PPV alone for the management of GRT in the current study, except in decreasing the risk of RRD. Key Words: Giant retinal tear, Pars plana vitrectomy, Scleral buckling, Recurrent retinal detachment.
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http://dx.doi.org/10.29271/jcpsp.2021.08.953DOI Listing
August 2021

Alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fMRI study.

Sci Rep 2021 Jul 23;11(1):15059. Epub 2021 Jul 23.

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Center of National Ocular Disease Clinical Research Center, Nanchang, 330006, Jiangxi, China.

Previous neuroimaging studies demonstrated that patients with strabismus or amblyopia can show significant functional and anatomical changes in the brain, but alterations of interhemispheric functional connectivity (FC) have not been well studied in this population. The current study analyzed whole-brain changes of interhemispheric FC in children with strabismus and amblyopia (CSA) using voxel-mirrored homotopic connectivity (VMHC).A total of 24 CSA (16 males and 8 females) and 24 normal controls (NCs) consisting of 16 and 8 age-, sex, and education-matched males and females, respectively, underwent functional magnetic resonance imaging (fMRI) scans in the resting state. According to Gaussian random field theory, changes in the resting state FC (rsFC) between hemispheres were evaluated using the VMHC method. The relationships between mean VMHC values in multiple brain regions and behavioral performance were evaluated by Pearson correlation analysis. In contrast to NCs, the CSA group showed significantly decreased VMHC values in the bilateral cerebellum, bilateral frontal superior orbital (frontal sup orb), bilateral temporal inferior(temporal inf),and bilateral frontal superior(frontal sup). CSA have abnormal interhemispheric FC in many brain regions, which may reflect dysfunction of eye movements and visual fusion. These findings might provide insight into the underlying pathogenetic mechanisms of CSA.
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http://dx.doi.org/10.1038/s41598-021-92281-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302749PMC
July 2021

Altered spontaneous brain activity patterns in dysthyroid optic neuropathy: a resting-state fMRI study.

J Integr Neurosci 2021 Jun;20(2):375-383

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi Province, China.

This research investigates the characteristics of spontaneous brain activity in dysthyroid optic neuropathy patients using the regional homogeneity technique. Sixteen patients with dysthyroid optic neuropathy and 16 thyroid-associated ophthalmopathy patients without dysthyroid optic neuropathy were recruited, matched for weight, height, age, sex, and educational level. All participants underwent resting-state functional nuclear resonance imaging, and the characteristics of spontaneous brain activity were evaluated using the regional homogeneity technique. Each participant in the dysthyroid optic neuropathy group also completed the Hospital Anxiety and Depression scale. Receiver operating characteristic curves were used to compare brain activity between the two groups. Pearson correlation analysis evaluated the relationship between regional homogeneity and clinical manifestations in dysthyroid optic neuropathy patients. In addition, we analyzed the correlation between Hospital Anxiety and Depression scale and regional homogeneity. We found that the regional homogeneity values at the corpus callosum/cingulate gyrus and parietal lobe/middle frontal gyrus significantly decreased in dysthyroid optic neuropathy patients. Regional homogeneity values at the corpus callosum/cingulate gyrus and parietal lobe/middle frontal gyrus were negatively correlated with Hospital Anxiety and Depression scale and disease duration. It was found that the regional homogeneity signal values were significantly lower than in thyroid-associated ophthalmopathy without in dysthyroid optic neuropathy, which may indicate a risk of regional brain dysfunction in dysthyroid optic neuropathy. The results show that regional homogeneity has the potential for early diagnosis and prevent dysthyroid optic neuropathy. In addition, the findings suggest possible mechanisms of dysthyroid optic neuropathy optic nerve injury. They may provide a valuable basis for further research on the pathological mechanisms of dysthyroid optic neuropathy.
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http://dx.doi.org/10.31083/j.jin2002037DOI Listing
June 2021

Comparing the effects of humic acid and oxalic acid on Pb(II) immobilization by a green synthesized nanocrystalline hydroxyapatite.

Chemosphere 2021 Jul 6;285:131411. Epub 2021 Jul 6.

Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control, Shenzhen, 518055, China; State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control, School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen, 518055, China. Electronic address:

Dissolved organic matter (DOM) is one of the most significant parameters to affect the remediation efficiency of Pb(II) by apatites. Numerous studies chose humic substances as a surrogate of DOM to investigate its influence on Pb(II) immobilization. However, the effect of low-molecular-weight organic acids such as oxalic acid (OA), which is ubiquitous in the environment and a primary component of DOM, in immobilizing Pb(II) was still not fully understood. Herein, humic acid (HA) and OA were examined to distinguish their influence on Pb(II) immobilization by a green synthesized nanocrystalline hydroxyapatite (nHAP). Various parameters were considered to evaluate the removal performance of nHAP towards Pb(II) as affected by HA/OA. Results indicated that Pb(II) immobilization was significantly promoted in the coexistence of OA owing to the precipitation of hydroxypyromorphite (HPY) as well as PbCO, but was independent on the addition sequence and slightly hindered by HA, disclosing that Pb(II) preferred to bind directly with nHAP instead of via HA. Characterization of the Pb(II) loaded solids by multiple technologies revealed that HPY was the predominant precipitate both in the absence and presence of HA, while the formation of PbCO was preferred over that of HPY in the existence of OA. X-ray photoelectron spectroscopy indicated that PbCO was the prevalent solid phase with the ratio of 62.97% after Pb(II) immobilization by nHAP in the presence of OA. These findings implied that the transformation efficiency of Pb(II) to HPY by apatites can be overestimated in the presence of OA due to the precipitation of PbCO.
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http://dx.doi.org/10.1016/j.chemosphere.2021.131411DOI Listing
July 2021

Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development.

PLoS Genet 2021 Jul 9;17(7):e1009654. Epub 2021 Jul 9.

Department of Ecology and Evolution, The University of Chicago, Chicago, Illinois, United States of America.

It is a conventionally held dogma that the genetic basis underlying development is conserved in a long evolutionary time scale. Ample experiments based on mutational, biochemical, functional, and complementary knockdown/knockout approaches have revealed the unexpectedly important role of recently evolved new genes in the development of Drosophila. The recent progress in the genome-wide experimental testing of gene effects and improvements in the computational identification of new genes (< 40 million years ago, Mya) open the door to investigate the evolution of gene essentiality with a phylogenetically high resolution. These advancements also raised interesting issues in techniques and concepts related to phenotypic effect analyses of genes, particularly of those that recently originated. Here we reported our analyses of these issues, including reproducibility and efficiency of knockdown experiment and difference between RNAi libraries in the knockdown efficiency and testing of phenotypic effects. We further analyzed a large data from knockdowns of 11,354 genes (~75% of the Drosophila melanogaster total genes), including 702 new genes (~66% of the species total new genes that aged < 40 Mya), revealing a similarly high proportion (~32.2%) of essential genes that originated in various Sophophora subgenus lineages and distant ancestors beyond the Drosophila genus. The transcriptional compensation effect from CRISPR knockout were detected for highly similar duplicate copies. Knockout of a few young genes detected analogous essentiality in various functions in development. Taken together, our experimental and computational analyses provide valuable data for detection of phenotypic effects of genes in general and further strong evidence for the concept that new genes in Drosophila quickly evolved essential functions in viability during development.
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http://dx.doi.org/10.1371/journal.pgen.1009654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270118PMC
July 2021

Diagnostic Performance of SGA, PG-SGA and MUST for Malnutrition Assessment in Adult Cancer Patients: A Systematic Literature Review and Hierarchical Bayesian Meta-Analysis.

Nutr Cancer 2021 Jun 30:1-13. Epub 2021 Jun 30.

Department of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China.

Because cancer-associated malnutrition is a major health complication, timely nutritional screening is of utmost importance. The aim of this study was to conduct a systematic literature review and meta-analysis of three tools in order to identify the method with the best diagnostic performance. PubMed, EMBASE and Cochrane central register of controlled trials were searched for articles published from database inception to January 2021. Studies that assessed the diagnostic accuracy of the SGA, PG-SGA or MUST in adult cancer patients were included. In order to evaluate the quality of each included study, the QUADAS-2 tool was used after which a meta-analysis was conducted using the hierarchical bivariate model. This model accounts for both within and between study variability. 16 studies (18 datasets) were included to evaluate these tools. The overall sensitivity and specificity for SGA was 0.69 and 0.80, 0.95 and 0.81 for PG-SGA, along with 0.83 and 0.83 for MUST respectively. An assessment of the likelihood ratios showed that PG-SGA had the highest LR + and the lowest LR-, it therefore has the best diagnostic performance to confirm malnutrition in adult cancer patients.
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http://dx.doi.org/10.1080/01635581.2021.1942080DOI Listing
June 2021

Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study.

Sci Rep 2021 Jun 21;11(1):12943. Epub 2021 Jun 21.

Department of Ophthalmology and Radiology, Jiangxi Center of Natural Ocular Disease Clinical Research Center, The First Affiliated Hospital of Nanchang University, No 17, YongWaiZheng Street, DongHu District, Nanchang, 330006, Jiangxi, People's Republic of China.

This study investigated neurologic changes in patients with dry eye (DE) by functional magnetic resonance imaging (fMRI) and to used regional homogeneity (ReHo) analysis to clarify the relationship between these changes and clinical features of DE. A total of 28 patients with DE and 28 matched healthy control (HC) subjects (10 males and 18 females in each group) were enrolled. fMRI scans were performed in both groups. We carried out ReHo analysis to assess differences in neural activity between the 2 groups, and receiver operating characteristic curve (ROC) analysis was performed to evaluate the performance of ReHo values of specific brain areas in distinguishing DE patients from HCs. The relationship between average ReHo values and clinical characteristics was assessed by correlation analysis. ReHo values of the middle frontal gyrus, inferior frontal gyrus, and superior frontal gyrus were significantly lower in DE patients compared to HCs. The ROC analysis showed that ReHo value had high accuracy in distinguishing between DE patients and HCs (P < 0.0001). The ReHo values of the middle frontal gyrus and dorsolateral superior frontal gyrus were correlated to disease duration (P < 0.05). Symptoms of ocular surface injury in DE patients are associated with dysfunction in specific brain regions, which may underlie the cognitive impairment, psychiatric symptoms, and depressive mood observed in DE patients. The decreased ReHo values of some brain gyri in this study may provide a reference for clinical diagnosis and determination of treatment efficacy.
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http://dx.doi.org/10.1038/s41598-021-92199-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217547PMC
June 2021

Abnormal interhemispheric functional connectivity in patients with strabismic amblyopia: a resting-state fMRI study using voxel-mirrored homotopic connectivity.

BMC Ophthalmol 2021 Jun 9;21(1):255. Epub 2021 Jun 9.

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Background: Previous studies have demonstrated that strabismus amblyopia can result in markedly brain function alterations. However, the differences in spontaneous brain activities of strabismus amblyopia (SA) patients still remain unclear. Therefore, the current study intended to employthe voxel-mirrored homotopic connectivity (VMHC) method to investigate the intrinsic brain activity changes in SA patients.

Purpose: To investigate the changes in cerebral hemispheric functional connections in patients with SA and their relationship with clinical manifestations using the VMHC method.

Material And Methods: In the present study, a total of 17 patients with SA (eight males and nine females) and 17 age- and weight-matched healthy control (HC) groups were enrolled. Based on the VMHC method, all subjects were examined by functional magnetic resonance imaging. The functional interaction between cerebral hemispheres was directly evaluated. The Pearson's correlation test was used to analyze the clinical features of patients with SA. In addition, their mean VMHC signal values and the receiver operating characteristic curve were used to distinguish patients with SA and HC groups.

Results: Compared with HC group, patients with SA had higher VMHC values in bilateral cingulum ant, caudate, hippocampus, and cerebellum crus 1. Moreover, the VMHC values of some regions were positively correlated with some clinical manifestations. In addition, receiver operating characteristic curves presented higher diagnostic value in these areas.

Conclusion: SA subjects showed abnormal brain interhemispheric functional connectivity in visual pathways, which might give some instructive information for understanding the neurological mechanisms of SA patients.
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http://dx.doi.org/10.1186/s12886-021-02015-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188699PMC
June 2021

Altered brain network centrality in patients with mild cognitive impairment: an fMRI study using a voxel-wise degree centrality approach.

Aging (Albany NY) 2021 06 9;13(11):15491-15500. Epub 2021 Jun 9.

Department of Ophthalmology and Geriatric Medicine, The First Affiliated Hospital of Nanchang University, Jiangxi Center of Natural Ocular Disease Clinical Research Center, Nanchang 330006, Jiangxi, China.

Purpose: Previous studies in patients with Alzheimer's disease have shown amyloid beta accumulation in the brain and abnormal brain activity, with mild cognitive impairment (MCI) in early stages of the disease. The aim of the current study was to investigate functional connectivity in patients with MCI.

Methods: We recruited 24 subjects in total, including 12 patients with MCI (6 men and 6 women) and 12 healthy controls (HCs) (6 men and 6 women), matched for age, gender, and lifestyle factors. All subjects underwent resting-state functional magnetic resonance imaging scans and voxel-wise degree centrality (DC) was used to evaluate alterations in the strength of brain network connectivity.

Results: The DC value of the left inferior temporal gyrus was lower in MCI but significantly higher in the right fusiform gyrus and the left supplementary motor area, compared with HCs. The DC value in left inferior temporal gyrus correlated positively with disease duration and negatively with Mini-Mental State Examination. ROC curve analysis of brain regions showed acceptable specificity and accuracy of DC values between MCIs and HCs in the area under the curve (right fusiform gyrus, 0.955; left supplementary motor area, 0.992; left inferior temporal gyrus, 1.000).

Conclusions: Abnormal functional connectivity in brain regions of patients with MCI may reflect the pathological process of Alzheimer's disease development and could prove useful in clinical diagnosis and treatment.
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http://dx.doi.org/10.18632/aging.203105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221306PMC
June 2021

[Genetic testing and genotype-phenotype analysis for a child with X-linked hypohidrotic ectodermal dysplasia].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2021 Jun;38(6):557-560

Department of Dermatology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, Henan 450003, China.

Objective: To carry out genetic testing for a Chinese patient with X-linked hypohidrotic ectodermal dysplasia (XLHED) and explore its genotype-phenotype correlation.

Methods: Clinical data of the patient was collected. Peripheral blood samples were taken from the patient, his parents and 100 unrelated healthy controls. Genetic variants were detected by using next-generation sequencing using a skin-disease panel through targeted capture and next generation sequencing. Candidate variant was verified by Sanger sequencing. All literature related to genetic testing of XLHED patients in China was searched in the database, and the genotypes and phenotypes of patients in the literature and the correlation between them were statistically analyzed.

Results: A novel splice site variant c.655_689del was detected in the patient but not among his parents and the 100 unrelated healthy controls. So far 61 variants of the EDA gene have been identified among Chinese patients with XLHED, which suggested certain degree of genotype-phenotype correlation.

Conclusion: A novel c.655_689del variant has been identified in the EDA gene, which has expanded the spectrum of EDA gene variant and facilitated delineation of the genotype-phenotype correlation of XLHED.
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http://dx.doi.org/10.3760/cma.j.cn511374-20200622-00464DOI Listing
June 2021

Exposure to outdoor air pollution at different periods and the risk of leukemia: a meta-analysis.

Environ Sci Pollut Res Int 2021 Jul 19;28(27):35376-35391. Epub 2021 May 19.

Department of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, 10# Xitoutiao, Youanmenwai Street, Beijing, 100069, China.

The causes of leukemia remain largely unknown; our aims were to examine the association between the exposure to outdoor air pollution and leukemia risk and to explore the effect of this exposure during different periods of pregnancy and early life. We searched for all case-control and cohort studies published before February 20, 2021, which measured the risk of leukemia in relation to exposure to the air pollutants: particulate matter, benzene, nitrogen dioxide (NO), and nitrogen oxides (NO). We then carried out a meta-analysis and calculated the summary relative risks (RRs) of leukemia by using a random-effects model. The potential dose-response relationship was further explored. The results showed that the highest exposure to benzene (RR: 1.20, 95%CI: 1.06-1.35) and NO (RR: 1.04, 95%CI; 1.02-1.08) were positively correlated with leukemia risk when compared to the lowest exposure categories for each air pollutant. During pregnancy, exposure to benzene in the third trimester, as well as exposure to NO in the second trimester and entire pregnancy, could also increase the risk of leukemia. In the dose-response analysis, benzene exposure and NO exposure were linearly associated with the risk of leukemia. Other air pollutants did not have a statistical correlation with leukemia risk. There was a certain degree of publication bias in studies on benzene. Overall, our results support a link between outdoor air pollution and leukemia risk, particularly due to benzene and NO. Prospero Registration Number: PROSPERO CRD42020207025.
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http://dx.doi.org/10.1007/s11356-021-14053-8DOI Listing
July 2021

Interhemispheric Functional Connectivity Alterations in Diabetic Optic Neuropathy: A Resting-State Functional Magnetic Resonance Imaging Study.

Diabetes Metab Syndr Obes 2021 11;14:2077-2086. Epub 2021 May 11.

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, People's Republic of China.

Purpose: Previous research suggests that diabetic optic neuropathy (DON) can cause marked anatomical and functional variations in the brain, but to date altered functional synchronization between two functional hemispheres remains uncharacterized in DON patients. Voxel mirrored homotopic connectivity (VMHC) is a voxel-based method to evaluate the synchronism between two mirrored hemispheric by determining the functional connectivity between each voxel in one hemisphere and its counterpart. In this study, we aim to assess abnormal changes in interhemispheric functional connectivity in DON patients via the VMHC method.

Methods: The study included 28 adult DON patients (12 male, 16 female) and 28 healthy controls (12 male, 16 female) who were closely matched for sex and age. Participants were examined using resting-state functional magnetic resonance imaging. The VMHC method was applied to investigate the abnormal state in bilateral hemispheres in DON patients and the same regions in healthy controls, as well as the receiver operating characteristic (ROC) curves were used to evaluate characteristics. Associations between altered VMHC values in distinct cerebral regions and clinical features were assessed via correlational analysis.

Results: Markedly lower VMHC values were evident in the right temporal inferior, the left temporal inferior, the right mid-cingulum, the left mid-cingulum, the right supplementary motor region, and the left supplementary motor region in DON patients compared with healthy controls. ROC curve analysis suggested that the application of VMHC is reliable for the diagnosis of DON.

Conclusion: Anomalous interhemispheric functional connectivity in specific brain areas caused by DON may indicate neuropathologic mechanisms of vision loss and blurry vision in patients with DON.
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http://dx.doi.org/10.2147/DMSO.S303782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123950PMC
May 2021

Spontaneous functional changes in specific cerebral regions in patients with hypertensive retinopathy: a resting-state functional magnetic resonance imaging study.

Aging (Albany NY) 2021 05 10;13(9):13166-13178. Epub 2021 May 10.

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Centre of Natural Ocular Disease Clinical Research Center, Nanchang 330006, Jiangxi, People's Republic of China.

This study investigated functional alterations in the cerebral network of patients with hypertensive retinopathy (HR) by resting-state functional magnetic resonance imaging (rs-fMRI) and degree centrality (DC) methods. 31 patients with HR along with 31 healthy controls (HC) closely matched in gender and age were enrolled for the research. All participants were examined by rs-fMRI, and the DC method was applied to evaluate alterations in spontaneous cerebral activity between the 2 groups. We used the independent samples test to evaluate demographic and general information differences between HR patients and HCs. The 2-sample test was used to compare the DC values of different cerebral regions between the 2 groups. The accuracy of differential diagnostic HR was analyzed by receiver operating characteristic (ROC) curve method for rs-fMRI DC values changes. Pearson's correlation coefficient was applied to determine the correlation between differences in DC in specific cerebral areas and clinical manifestation. Results showed that DC values were higher in the left cerebellum posterior lobe (LCPL), left medial occipital gyrus (LMOG), and bilateral precuneus (BP) of HR patients compared to HCs. Mean DC values were lower in the right medial frontal gyrus/bilateral anterior cingulate cortex of HR patients. Anxiety and depression scores were positively correlated with DC values of LMOG and LCPL, respectively. Bilateral best-corrected visual acuity in HR patients was negatively correlated with the DC value of BP. Hence, changes in DC in specific cerebral areas of patients with HR reflect functional alterations that provide insight into the pathophysiologic mechanisms of HR.
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http://dx.doi.org/10.18632/aging.202999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148467PMC
May 2021

Fractional amplitude of low-frequency fluctuation in patients with neovascular glaucoma: a resting-state functional magnetic resonance imaging study.

Quant Imaging Med Surg 2021 May;11(5):2138-2150

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center, Nanchang, China.

Background: Neovascular glaucoma (NVG) is a secondary refractory disease with a poor prognosis, and there are few advanced studies on its pathogenesis and treatment. In this research, the fractional amplitude of low-frequency fluctuation (fALFF) technology was used in resting-state functional magnetic resonance imaging (rsfMRI) to investigate intrinsic neuron activity in the patient's brain with NVG.

Methods: Sixteen patients with NVG (eight males and eight females) and 16 healthy controls (HCs) of similar age and sex were included. All patients and controls received rsfMRI scans, and the differences between the two groups in fALFF values were compared by independent sample t-test. Receiver operating characteristic (ROC) curves were used to compare fALFF values in the brain regions of NVG patients and HCs and assess accuracy. Finally, Pearson linear correlation analysis assessed the correlation between fALFF signals in brain regions and the clinical evaluation indicators of patients with NVG.

Results: In patients with NVG, fALFF signal values in the right Rolandic operculum, left anterior cingulate and paracingulate gyri, and right caudate were significantly decreased. In contrast, fALFF signal values in the left precuneus were significantly higher than those recorded in the HCs. Analysis of the ROC curve for each brain region showed that the area under the ROC curve of NVG patients was large (close to 1), and the accuracy was good. In the NVG group, the hospital anxiety and depression scale (r=-0.952, P<0.001) and left best-corrected visual acuity (r=-0.802, P<0.001) had a negative linear correlation with the fALFF signal value of the right Rolandic operculum. The hospital anxiety and depression scale had a negative linear correlation with the fALFF signal value of the right caudate (r=-0.948, P<0.001).

Conclusions: NVG patients showed dysfunction in several brain regions. These findings may assist in revealing the underlying neural mechanism of brain activity associated with NVG.
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http://dx.doi.org/10.21037/qims-20-855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047371PMC
May 2021
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