Publications by authors named "Yi Luo"

1,545 Publications

  • Page 1 of 1

Gut microbiota exaggerates triclosan-induced liver injury via gut-liver axis.

J Hazard Mater 2021 Jul 21;421:126707. Epub 2021 Jul 21.

College of Environmental Sciences and Engineering, Nankai University, Tianjin 300350, China; State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210046, China. Electronic address:

Triclosan (TCS) is an antimicrobial ingredient that has been widely incorporated in consumer products. TCS can cause hepatic damage by disturbing lipid metabolism, which is often accompanied with gut microbiota dysbiosis. However, the effects of gut microbiota on the TCS-induced liver injury are still unknown. Therefore, we constructed a mouse model based on five-week-old male C57BL/6 mice to investigate the effects of dietary TCS exposure (40 ppm) on liver injury. We found that TCS treatment for 4 weeks dramatically disturbed gut microbiota homeostasis, resulting in overproduction of lipopolysaccharides (LPS) and deficiency of secondary bile acids such as deoxycholic acid (DCA) and lithocholic acid (LCA). In addition, TCS considerably increased intestinal permeability by reducing mucus excretion and expression of tight junction proteins (ZO-1, occludin and claudin 4), which facilitated translocation of LPS. The LPS accumulation in blood contributed to liver injury by triggering the inflammatory response via TLR4 pathway. In summary, this study provides novel insights into the underlying mechanisms of TCS-associated liver injury induced by gut microbiota via the gut-liver axis, and contributes to better interpretation of the health impact of the environmentally emerging contaminant TCS.
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http://dx.doi.org/10.1016/j.jhazmat.2021.126707DOI Listing
July 2021

Quantitative particle agglutination assay for point-of-care testing using mobile holographic imaging and deep learning.

Lab Chip 2021 Jul 22. Epub 2021 Jul 22.

Electrical & Computer Engineering Department, University of California, Los Angeles, California 90095, USA. and California NanoSystems Institute (CNSI), University of California, Los Angeles, California 90095, USA and Bioengineering Department, University of California, Los Angeles, California 90095, USA.

Particle agglutination assays are widely adopted immunological tests that are based on antigen-antibody interactions. Antibody-coated microscopic particles are mixed with a test sample that potentially contains the target antigen, as a result of which the particles form clusters, with a size that is a function of the antigen concentration and the reaction time. Here, we present a quantitative particle agglutination assay that combines mobile lens-free microscopy and deep learning for rapidly measuring the concentration of a target analyte; as its proof-of-concept, we demonstrate high-sensitivity C-reactive protein (hs-CRP) testing using human serum samples. A dual-channel capillary lateral flow device is designed to host the agglutination reaction using 4 μL of serum sample with a material cost of 1.79 cents per test. A mobile lens-free microscope records time-lapsed inline holograms of the lateral flow device, monitoring the agglutination process over 3 min. These captured holograms are processed, and at each frame the number and area of the particle clusters are automatically extracted and fed into shallow neural networks to predict the CRP concentration. 189 measurements using 88 unique patient serum samples were utilized to train, validate and blindly test our platform, which matched the corresponding ground truth concentrations in the hs-CRP range (0-10 μg mL-1) with an R2 value of 0.912. This computational sensing platform was also able to successfully differentiate very high CRP concentrations (e.g., >10-500 μg mL-1) from the hs-CRP range. This mobile, cost-effective and quantitative particle agglutination assay can be useful for various point-of-care sensing needs and global health related applications.
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http://dx.doi.org/10.1039/d1lc00467kDOI Listing
July 2021

Dasatinib enhances anti-leukemia efficacy of chimeric antigen receptor T cells by inhibiting cell differentiation and exhaustion.

J Hematol Oncol 2021 Jul 21;14(1):113. Epub 2021 Jul 21.

Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, No.79 Qingchun Road, Hangzhou, China.

Relapses of CD19-expressing leukemia in patients who achieved initial remission after CART cell treatment have been reported to correlate with poor CART cells persistence. Sustained tonic signaling or strong activation drives CART cell differentiation and exhaustion, which limit the therapeutic efficacy and persistence of CART cells. Here, we identified dasatinib as the optimal candidate to prevent or reverse both CD28/CART and 4-1BB/CART cell differentiation and exhaustion during ex vivo expansion, which profoundly enhanced the therapeutic efficacy and in vivo persistence. Moreover, strong activation-induced CART cells differentiation, exhaustion and apoptosis driven by CD3/CD28 stimulation or antigen exposure were dramatically prevented or reversed by dasatinib treatment. Mechanistically, dasatinib markedly reduced the phosphorylation of Src and Lck, and downregulated the expression of genes involved in CAR signaling pathways, which resulted in the optimization of cell differentiation, exhaustion and apoptosis-related gene expression. Our study proposes a promising pharmacological approach for optimizing CART cells manufacture, and provides an experimental basis for reinvigorating CART cells in clinical application.
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http://dx.doi.org/10.1186/s13045-021-01117-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293573PMC
July 2021

Prevalence and Characteristics of Rheumatoid-Associated Autoantibodies in Patients with COVID-19.

J Inflamm Res 2021 12;14:3123-3128. Epub 2021 Jul 12.

Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.

Objective: Patients with rheumatic immune diseases were more likely to develop severe or critical COVID-19. We aimed to determine whether rheumatoid factor antibodies were present in COVID patients and the level and type of rheumatoid factor antibodies produced in COVID-19 patients were related to the degree of the patient's condition. The study also aimed to determine the prevalence and characteristics of rheumatoid factor antibodies in patients with COVID-19.

Methods: Sera collected from 129 patients with COVID-19 were tested for rheumatoid factor antibodies by ELISA. Five patients were tracked for several months to monitor dynamic changes of these antibodies.

Results: Rheumatoid-associated autoantibodies were detected in 20.16% of patients (26/129) following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In addition, IgM-RF was primarily present in critically ill patients, while IgA-RF was mainly present in mild patients. Five patients were able to track for several months to monitor dynamic changes of these antibodies. Rheumatoid factor antibodies peaks in the later phase of the disease and last for longer time. Anti-Jo-1 antibody was found in one of the five patients.

Conclusion: This was the case series report that rheumatoid-associated autoantibodies are present in patients with COVID-19. The clinical significance of these antibodies was not fully understood and needed further characterization. These autoantibodies are related to the severity of the patient's disease and exist for a long time in the patient's body, while their impact on the patient's health is unknown.
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http://dx.doi.org/10.2147/JIR.S312090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286246PMC
July 2021

Occurrence of hypertension during third-line anlotinib is associated with progression-free survival in patients with squamous cell lung cancer (SCC): A post hoc analysis of the ALTER0303 trial.

Thorac Cancer 2021 Jul 17. Epub 2021 Jul 17.

Department of Oncology, Linyi Cancer Hospital, Linyi, China.

Background: There is a lack of targeted therapeutic options for squamous cell lung cancer (SCC). Accelerated hypertension is an issue with many targeted therapies for lung cancer. This study aimed to analyze the efficacy of anlotinib, based on progression-free survival (PFS) and overall survival (OS) in patients with SCC, stratified by hypertension and Eastern Cooperative Oncology Group (ECOG) score.

Methods: This was a post hoc analysis of a multicenter, double-blind, phase III ALTER0303 randomized controlled trial. Only patients with SCC were included. The occurrence of hypertension during the study period was defined according to CTCAE 4.03. OS and PFS were the primary and secondary endpoints, respectively. The patients were stratified according to hypertension and ECOG score, respectively.

Results: The median PFS in the patients who developed hypertension was longer than in those who did not (7.2 (95% CI: 3.5-11.0) versus 3.2 (95% CI: 1.2-5.3) months, p = 0.001; HR (95% CI), 0.4 (0.2-0.8)). In the ECOG 0 patients, the median PFS in the patients who developed hypertension versus those who did not was 5.6 vs. 1.8 months, respectively (Figure 2(d)). In the ECOG 1 patients, the median PFS in the patients who developed hypertension versus those who did not was 7.0 (95% CI: 3.0-11.0) vs. 4.8 (95% CI: 1.2-8.5) months (p = 0.043). No statistically significant differences were found in OS in the stratified analyses.

Conclusions: The occurrence of hypertension might be a clinical indicator predicting the efficacy of third-line anlotinib treatment in patients with SCC.
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http://dx.doi.org/10.1111/1759-7714.14076DOI Listing
July 2021

Analysis of the Prognostic Value and Gene Expression Mechanism of in Lung Adenocarcinoma.

Front Mol Biosci 2021 28;8:688274. Epub 2021 Jun 28.

The Center of Pathological Diagnosis and Research, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.

Detection of methylation has been used to assist in the early diagnosis of lung cancer in many hospitals as may be important in the tumorigenesis of lung cancer. However, there are few studies on the mRNA expression, methylation, and molecular mechanism of in lung cancer. We aimed to explore the role of in lung adenocarcinoma (LUAD). First, we examined the differential expression of mRNA and methylation in cancerous and normal tissues using databases. Second, we analyzed the relationship between expression and common clinical parameters in LUAD patients. Third, we further explored the methylated level and its specific location of and the mainly factors of gene expression. Finally, we screened the correlatively expressed genes to analyze the pathways from the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes using DAVID. We found that the mRNA expression of was higher in multiple cancers, including LUAD and lung squamous cell carcinoma (LUSC), than in normal tissues. Among LUAD patients, expression was higher in patients of middle-young age, with smoking history, in advanced stages, and with nodal distant metastasis. In addition, our results showed that patients with high expression of are prone to recurrence, poor differentiation, and poor prognosis. Thus, we identified that might be an oncogene for LUAD progression. The main factor influencing the high expression of mRNA may be DNA methylation, followed by copy number variation (CNV), but not by gene mutations in LUAD. Unexpectedly, we found that undergoes hypomethylation in the gene body instead of hypermethylation in the promoter. Additionally, SHOX2 has cross talk in the PI3K-Akt signaling pathway and ECM-receptor interaction. is highly expressed in most cancers. gene expression might be mainly regulated by methylation of its gene body in LUAD, and its high expression or hypomethylation indicates poor differentiation and poor prognosis. SHOX2 could be involved in PI3K-Akt and other important cancer-related signaling pathways to promote tumorigenesis.
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http://dx.doi.org/10.3389/fmolb.2021.688274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273341PMC
June 2021

Salvage Therapy With Low-Dose Ruxolitinib Leads to a Significant Improvement in Bronchiolitis Obliterans Syndrome in Patients With cGVHD After Allogeneic Hematopoietic Stem Cell Transplantation.

Front Pharmacol 2021 28;12:668825. Epub 2021 Jun 28.

Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Bronchiolitis obliterans syndrome (BOS) is a life-threatening pulmonary manifestation of chronic graft versus host disease (cGVHD) post-allogeneic hematopoietic stem cell transplantation (HSCT), without clear standard of care. This study included 30 patients undergoing an allogeneic HSCT for a hematological malignancy and the outcomes with post-HSCT BOS treated with ruxolitinib as a salvage treatment were reviewed. After a median duration of ruxolitinib therapy of 9.25 (1.5-27) months, the best overall response (BOR) rate was 66.7%: three patients (10.0%) achieved complete remission, and 17 (56.7%) achieved partial remission. The median time from initiation of ruxolitinib to achieve the best responses was 3 months. Since initiating ruxolitinib, forced expiratory volume in 1 s of predicted (FEV1%pred) slightly increased after 3 and 6 months compared with measurements before ruxolitinib in responders. Only FEV1%pred mild decline before ruxolitinib with a ratio ≤15% was an independent predictor to achieve a response to ruxolitinib. Eleven patients (36.7%) had severe pulmonary infection of ≥3 grade. Following a median follow-up of 318 days after ruxolitinib, the 2-years incidence of nonrelapse mortality and 2-years overall survival rate after ruxolitinib among patients with BOS was 25.1 and 62.6%, respectively. Ruxolitinib is a promising treatment option to improve the prognosis of post-HSCT BOS.
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http://dx.doi.org/10.3389/fphar.2021.668825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273229PMC
June 2021

Neuronal activity-induced BRG1 phosphorylation regulates enhancer activation.

Cell Rep 2021 Jul;36(2):109357

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

Neuronal activity-induced enhancers drive gene activation. We demonstrate that BRG1, the core subunit of SWI/SNF-like BAF ATP-dependent chromatin remodeling complexes, regulates neuronal activity-induced enhancers. Upon stimulation, BRG1 is recruited to enhancers in an H3K27Ac-dependent manner. BRG1 regulates enhancer basal activities and inducibility by affecting cohesin binding, enhancer-promoter looping, RNA polymerase II recruitment, and enhancer RNA expression. We identify a serine phosphorylation site in BRG1 that is induced by neuronal stimulations and is sensitive to CaMKII inhibition. BRG1 phosphorylation affects its interaction with several transcription co-factors, including the NuRD repressor complex and cohesin, possibly modulating BRG1-mediated transcription outcomes. Using mice with knockin mutations, we show that non-phosphorylatable BRG1 fails to efficiently induce activity-dependent genes, whereas phosphomimic BRG1 increases enhancer activity and inducibility. These mutant mice display anxiety-like phenotypes and altered responses to stress. Therefore, we reveal a mechanism connecting neuronal signaling to enhancer activities through BRG1 phosphorylation.
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http://dx.doi.org/10.1016/j.celrep.2021.109357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315893PMC
July 2021

Blinatumomab for HLA loss relapse after haploidentical hematopoietic stem cell transplantation.

Am J Cancer Res 2021 15;11(6):3111-3122. Epub 2021 Jun 15.

Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou, Zhejiang Province, China.

Loss of patient-specific HLA after haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is considered as a relapse mechanism for lacking the incompatible molecule to elicit alloreactivity, which extensively diminishing graft-versus-leukemia (GVL) effects. Blinatumomab, as a CD3/CD19 bispecific antibody, can yield a profound response via redirecting T cells towards malignant lymphoblasts in B-cell acute lymphoblastic leukemia (B-ALL). We aimed to assess the feasibility of blinatumomab in treating patients with HLA loss relapse after haplo-HSCT. Four eligible patients undergoing HLA loss relapse after haplo-HSCT were enrolled in the study. Four patients achieved a complete remission/complete remission with partial he-matologic recovery (CR/CRh) with three minimal residual disease (MRD)-negative response within the first cycle of treatment. Three of the four met a primary endpoint with CR/CRh and MRD-negative response within 2 cycles of treatment. One patient developed new extramedullary sites of skin after the first cycle. Cytokine release syndrome was observed in one patient. Cytopenias, as well as elevated alanine aminotransferase and aspartate aminotransferase, were two common adverse effects during treatment. By redirecting lysis of CD19-positive lymphoblast who losing the incompatible HLA, blinatumomab is a potential strategy to eradicate malignant cells via restoring GVL effects. A randomized clinical trial assessing blinatumomab in patients with HLA loss relapse after HSCT is warranted.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263683PMC
June 2021

Sub-Picosecond Nanodiodes for Low-Power Ultrafast Electronics.

Adv Mater 2021 Jul 9:e2100874. Epub 2021 Jul 9.

Micro/Nano Fabrication Laboratory (MNFL), Microsystem and Terahertz Research Center, CAEP, Chengdu, 610200, China.

The tradeoff between ultrahigh speed and low power is a dominant challenge in continuously improving modern electronics. Fundamental electronic devices with ultrafast response are highly desired in low-power electronics. However, conventional semiconductor electronic devices now near the speed limit from the physical roadblocks including short-channel effect, restricted carrier velocity, and heat death. Currently emerging electronic devices also face formidable difficulties to achieve high-speed performance at low operating voltage without heat disturbance. Here, a novel fabricated coplanar tip-to-edge semiconductor-free nanostructure with asymmetric sub-10 nm air channel is reported, stimulating electric-field accelerated scattering-free transport of electrons and resulting in ultrafast response of record sub-picoseconds at a low turn-on voltage around 0.7 V. Simulation results show a typical electrical response down to 64 fs, which is ≈10 times faster than that of conventional semiconductor electronic devices. The coplanar asymmetric nanostructure allows a high rectifying ratio up to 10 which is superior to that of the most promising 2D semiconducting nanodiodes. In addition, heat death is overcome due to the inherent advantages from the novel nanostructure and underlying working mechanism. The intriguing nanodiodes will attract broadly interests in electronics due to their potential as rudimentary building blocks in ultrafast electronic integrated circuits.
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http://dx.doi.org/10.1002/adma.202100874DOI Listing
July 2021

Molecular Evidence of in Ticks in Border Areas of Xinjiang, China.

Front Vet Sci 2021 22;8:675457. Epub 2021 Jun 22.

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.

are gram-negative intracellular bacteria; certain species of can cause diseases in mammals and humans. Ticks play a major role in the transmission of . Xinjiang is the largest province in China according to land area and has one-third of the tick species in China; the infection rate of in ticks in the Xinjiang border areas has not been studied in detail. Therefore, this study investigated tick infections by in Xinjiang border areas, and the purpose of the study was to fill in gaps in information regarding the genetic diversity of tick infections by in Xinjiang. We tested 1,549 tick samples from domestic animals (sheep and cattle) for using -PCR. Positive samples from the -PCR assay for spp. were further subjected to PCR assays targeting the ITS, and genes followed by phylogenetic analyses. DNA was detected in 2.19% (34/1,549) of tick samples, and the ITS, and genes of gene-positive samples were amplified to identify nine samples of . In this study, molecular analysis was used to assess the presence and genetic diversity of in ticks collected from sheep and cattle from Xinjiang, China. This study provides new information on the presence and identity of in ticks from sheep and cattle.
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http://dx.doi.org/10.3389/fvets.2021.675457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258404PMC
June 2021

Household food waste in rural China: A noteworthy reality and a systematic analysis.

Waste Manag Res 2021 Jul 7:734242X211029168. Epub 2021 Jul 7.

College of Economics and Management, China Agricultural University, Beijing, China.

Economic development has improved people's daily diets in China, but food waste has increased significantly. China faces severe natural resource constraints, and reducing food waste is important for ensuring national food security. Based on 1634 survey samples from 28 provinces in China, this study assessed food waste in rural China and empirically analyzed the main factors affecting rural household food waste. The results showed that, on average, 1.67% of food is wasted per household each day in rural China. Food waste is greater in economically developed areas, such as East China. Empirical analysis showed that cooking utensils, preparing the right amount of food, religious beliefs, number of family members, average weight of family members, percentage of purchased grain in the total food consumption in 1 year, and total grain output are significantly related to rural household food waste.
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http://dx.doi.org/10.1177/0734242X211029168DOI Listing
July 2021

Dietary Supplementation of Octacosanol Improves Exercise-Induced Fatigue and Its Molecular Mechanism.

J Agric Food Chem 2021 Jul 5;69(27):7603-7618. Epub 2021 Jul 5.

National Engineering Laboratory for Deep Process of Rice and Byproducts, Hunan Key Laboratory of Grain-Oil Deep Process and Quality Control, Hunan Key Laboratory of Processed Food for Special Medical Purpose, College of Food Science and Engineering, Central South University of Forestry and Technology, No. 498, Shaoshan Road, Changsha 410004, Hunan, China.

Several publications report that octacosanol (OCT) has different biological functions. This study was designed to evaluate the antifatigue effect and molecular mechanism of octacosanol (200 mg/(kg day)) in forced exercise-induced fatigue models of trained male C57BL/6 mice. Results showed that octacosanol ameliorated the mice's autonomic activities, forelimb grip strength, and swimming endurance, and the levels of liver glycogen (LG), muscle glycogen (MG), blood lactic acid (BLA), lactate dehydrogenase (LDH), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) were also regulated. Gene analysis results showed that treatment with OCT upregulated 29 genes, while 38 genes were downregulated in gastrocnemius tissue. Gene ontology (GO) analyses indicated that these genes enriched functions in relation to myofibril, contractile fiber, and calcium-dependent adenosinetriphosphatase (ATPase) activity. Octacosanol supplementation significantly adjusted the messenger RNA (mRNA) and protein expression levels related to fatigue performance. Octacosanol has an observably mitigating effect in exercise-induced fatigue models, and its molecular mechanism may be related to the regulation of tripartite motif-containing 63 (Trim63), periaxin (Prx), calcium voltage-gated channel subunit α1 H (Cacna1h), and myosin-binding protein C (Mybpc3) expression.
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http://dx.doi.org/10.1021/acs.jafc.1c01764DOI Listing
July 2021

Identification and expression pattern analysis of miRNAs in pectoral muscle during pigeon () development.

PeerJ 2021 23;9:e11438. Epub 2021 Jun 23.

Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, China.

MicroRNAs (miRNAs) are a group of crucial regulators in the process of animal growth and development. However, little is known about the expression and function of miRNAs in pigeon muscles. To identify the miRNAs participating in the rapid development of pigeon pectoral muscles and quantitate their expression levels of pectoral muscles in different age stages, we performed miRNA transcriptome analysis in pigeon pectoral muscles by sequencing small RNAs over three different age stages (1-day old, 28 days old, and 2 years old). Dual-luciferase reporter assay was applied to validate the interaction between miRNA and its target gene. We identified 304 known miRNAs, 201 conserved miRNAs, and 86 novel miRNAs in pigeon pectoral muscles. 189 differentially expressed (DE) miRNAs were screened out during pigeon development. A short time-series expression miner (STEM) analysis indicated 89 DE miRNAs were significantly clustered in a progressively decreasing expression profile, and mainly enriched in biosynthesis-related GO categories and signaling pathways for MAPK and TGF-. Dual-luciferase reporter assay indicated that a progressively down-regulated miRNA (miR-20b-5p) could directly target Krüppel-like factor 3 () gene. To sum-up, our data expand the repertoire of pigeon miRNAs and enhance understanding of the mechanisms underlying rapid development in squabs.
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http://dx.doi.org/10.7717/peerj.11438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234919PMC
June 2021

[Pollution Characteristics of Organophosphate Esters in Frozen Soil on the Eastern Edge of Qinghai-Tibet Plateau].

Huan Jing Ke Xue 2021 Jul;42(7):3549-3554

College of Resources and Environment, Chengdu University of Information Technology, Chengdu 610225, China.

In this study, soil samples were collected from the eastern edge of the Qinghai Tibet Plateau in December 2019. The level and distribution characteristics of organophosphate esters (OPEs) in seasonal frozen soil were analyzed, and their sources were discussed. The results showed that the target analytes including tri-n-butyl phosphate (TnBP), tris(2-ethylhexyl) phosphate (TEHP), tributoxyethyl phosphate (TBEP), triphenyl phosphate (TPhP), tri(2-chloroethyl) phosphate (TCEP), trichloropropyl phosphate (TCPP), and tris-(2,3-dichloropropyl) phosphate (TDCPP) were detected with 100% frequency. Levels of ΣOPEs in topsoil (0-10 cm) and sub topsoil (10-20 cm) were 146.7-348.7 ng·g (mean:231.1 ng·g) and 206.5-333.2 ng·g (mean:260.2 ng·g), respectively. The ΣOPEs content level is comparable to that of urban soil,which is worthy of attention. TBEP and TDCPP were the most abundant compounds in the plateau soil. Point source emissions have significant influence on the spatial distribution of OPEs, and regional deposition of OPEs contributes to all sampling sites. The migration ability of different OPE compounds in soil was different. Stronger migration ability was observed for aromatic OPEs (TPhP) than chlorinated OPEs. Principal component analysis showed that the main sources of OPEs in plateau soil were atmospheric wet and dry deposition, manufactured consumer materials, and the release of OPEs from automobile interior decoration.
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http://dx.doi.org/10.13227/j.hjkx.202011196DOI Listing
July 2021

Size Effect of Graphene Quantum Dots on Photoluminescence.

Molecules 2021 Jun 26;26(13). Epub 2021 Jun 26.

Textile and Garment Industry of Research Institute, Zhongyuan University of Technology, Zhengzhou 450007, China.

High-photoluminescence (PL) graphene quantum dots (GQDs) were synthesized by a simple one-pot hydrothermal process, then separated by dialysis bags of different molecular weights. Four separated GQDs of varying sizes were obtained and displayed different PL intensities. With the decreasing size of separated GQDs, the intensity of the emission peak becomes much stronger. Finally, the GQDs of the smallest size revealed the most energetic PL intensity in four separated GQDs. The PL energy of all the separated GQDs shifted slightly, supported by density functional theory calculations.
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http://dx.doi.org/10.3390/molecules26133922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271461PMC
June 2021

Clinical therapeutic effects of acupuncture in treating patients with dysphagia after radiotherapy in nasopharyngeal carcinoma: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jul;100(26):e26410

Department of Otolaryngology, Wuhan Puren Hospital, Wuhan 430081, Hubei, China.

Background: Dysphagia is a commonly occurring condition in nasopharyngeal carcinoma (NPC) patients after radiotherapy. There has been an increasing number of studies focused on assessing the use of acupuncture to manage dysphagia. Moreover, the quality of the research has gradually increased. The present research will be conducted to systematically evaluate the efficiency and safety of using acupuncture to treat cases of dysphagia after radiation therapy in NPC patients.

Methods: Literature search will include all potential randomized controlled trials using MEDLINE, Cochrane Library, Web of Science, EMBASE, Chinese National Knowledge Infrastructure, Chinese BioMedical Literature, and WanFang database from their inception to May, 2021 without language or publication status restrictions, to evaluate the efficiency and safety of using acupuncture to treat dysphagia cases following radiation therapy in NPC patients. A couple of independent authors will select related literature, extract data from studies, and estimate this risk in the bias of the selected study articles. In the instance of contrasting opinions, the outcome is mediated through discussion with a different independent author. The data synthesis and statistical analysis will be completed with the RevMan software (version 5.3).

Results: This study will evaluate the efficiency and safety of using acupuncture to treat dysphagia cases after radiation therapy in NPC patients.

Conclusion: This study will determine the suitability of acupuncture as an effective and safe intervention for dysphagia in NPC patients after radiotherapy.

Ethics And Dissemination: The present study does not need ethical approval.

Registration Number: May 19, 2021.osf.io/f2cvt. (https://osf.io/f2cvt/).
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http://dx.doi.org/10.1097/MD.0000000000026410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257866PMC
July 2021

Experimental investigation of 16.6 Gbps SDM-WDM visible light communication based on a neural network receiver and tricolor mini-LEDs.

Opt Lett 2021 Jun;46(12):2888-2891

Visible light communication (VLC) based on a light-emitting diode (LED) suffers from a limited bandwidth of commercial LED, device nonlinearity, channel distortion, and transmitted power caused by a complex free-space channel, power amplifier, and illuminant devices resulting in a limited data rate. In this Letter, to provide an alternative high-speed solution, we first designed and fabricated three 175 µm tricolor mini-LEDs with various wavelengths. They are used to set up a spatial division multiplexing-wavelength division multiplexing VLC system over a 2 m link. Then we utilize a neural network receiver to replace the traditional channel estimation, equalization, and demodulation at the offline digital signal processing of the receiver. The experiment showed that the data rates of 2.65, 7, and 7 Gbps were achieved in three respective links using quadrature phase shift keying-optical orthogonal frequency division multiplexing. The three data rates have bit-error rates below the forward error correction limit, whose data rate sum of 16.6 Gbps is the highest mini/micro-LED-based VLC, to the best of our knowledge.
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http://dx.doi.org/10.1364/OL.428013DOI Listing
June 2021

Antibiotic Resistance Gene-Carrying Plasmid Spreads into the Plant Endophytic Bacteria using Soil Bacteria as Carriers.

Environ Sci Technol 2021 Jun 11. Epub 2021 Jun 11.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, China.

Applications of animal manure and treated wastewater could enrich antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in the plant microbiome. However, the mechanistic studies of the transmission of ARB and ARGs from the environment to plant endophytic bacteria were few. Herein, a genetically engineered fluorescent harboring a conjugative RP4 plasmid that carries three ARGs was used to trace its spread into interior in a tetracycline-amended hydroponic system in the absence or presence of a simulated soil bacterial community. Confocal microscope observation demonstrated that was internalized into plant tissues and the carried RP4 plasmid was transferred into plant endophytic bacteria. More importantly, we observed that soil bacteria inhibited the internalization of but substantially promoted RP4 plasmid spread into the plant microbiome. The altered RP4-carrying bacterial community composition in the plant microbiome and the increased core-shared RP4-carrying bacteria number between plant interior and exterior in the presence of soil bacteria collectively confirmed that soil bacteria, especially Proteobacteria, might capture RP4 from and then translocate into plant microbiome, resulting in the increased RP4 plasmid spread in the plant endophytes. Overall, our findings provided important insights into the dissemination of ARB and ARGs from the environment to the plant microbiome.
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http://dx.doi.org/10.1021/acs.est.1c01615DOI Listing
June 2021

Multiple Pulmonary Metastases of Recurrent Giant Cell Tumor of Bone with Expression of VEGFR-2 Successfully Controlled by Denosumab and Apatinib: A Case Report and Literature Review.

Cancer Manag Res 2021 3;13:4447-4454. Epub 2021 Jun 3.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China.

Giant cell tumor of bone (GCTB) is a rare, benign, but locally aggressive bone tumor. It has a high tendency for local recurrence, which may increase the incidence of lung metastasis. Currently, an optimal treatment strategy has not been established because of the rarity of pulmonary metastatic GCTB. Denosumab is the preferred regimen for unresectable metastatic lesions; however, there are no alternative treatment options when patients are resistant to denosumab. Apatinib is a small-molecule tyrosine kinase inhibitor that selectively competes for the vascular endothelial growth factor receptor 2 (VEGFR-2) ATP binding site, and several studies have analyzed the effectiveness of apatinib in advanced or metastatic tumors. However, there is no report of apatinib as an anti-angiogenesis therapy for pulmonary metastatic GCTB to date. Here, we present a case of a 26-year-old female who was diagnosed with recurrent and pulmonary metastatic GCTB. Immunohistochemical (IHC) staining indicated that the tumor cells were positive for VEGFR-2. Denosumab was administered to control the metastases; nevertheless, disease progression was confirmed after four months of treatment. Given the IHC results and rapid disease progression, apatinib was added to the treatment strategy. After 42 months of treatment, the patient showed noticeable symptomatic improvement and considerable tumor shrinkage.
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http://dx.doi.org/10.2147/CMAR.S312846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184137PMC
June 2021

Ocular manifestations in Chinese adult patients with NLRP3-associated autoinflammatory disease.

Sci Rep 2021 Jun 7;11(1):11904. Epub 2021 Jun 7.

Department of Ophthalmology, Key Laboratory of Ocular Fundus Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.

NLRP3-associated autoinflammatory disease (NLRP3-AID) is a rare autosomal dominant disorder involving multiple systems. We aim to assess the ocular manifestations of Chinese adult patients with NLRP3-AID. Twelve adult patients (> 18 years old) were diagnosed as NLRP3-AID at the Department of Rheumatology, Peking Union Medical College Hospital. All patients underwent ophthalmologic evaluation by an ophthalmologist. Clinical and genetic features of these patients were collected and compared with those from Caucasian population. A total of 7 NLRP3-AID patients (58%) 14 eyes had ocular manifestations. Five NLRP3 variants were identified, and 3 patients (43%) with severe ocular damages were all found to have the NLRP3 T348M variant. The incidences of papilledema and optic atrophy in the Chinese adult NLRP3-AID patients of moderate type were similar to those in the Caucasian NLRP3-AID patients of severe type. This is the first cohort of Chinese adult NLRP3-AID patients with ocular involvement. Ocular manifestations were diverse and even severe in NLRP3-AID, particularly in patients with the moderate phenotype, and may have relationship with genotypes. Awareness of these manifestations by rheumatologists and ophthalmologists could help to avoid the irreversible ocular damages.
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http://dx.doi.org/10.1038/s41598-021-91315-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184759PMC
June 2021

Hesperetin rescues emotional memory and synaptic plasticity deficit in aged rats.

Behav Neurosci 2021 Jun 7. Epub 2021 Jun 7.

Department of Neurology, The First People's Hospital of Jingzhou, the First Affiliated Hospital of Yangtze University.

Emotional memory deficit is often accompanied by Alzheimer's disease and normal aging. It is important to do what is possible to alleviate or rescue emotional memory deficit in aging to improve the quality of older adults. Hesperetin is a flavonoid and an aglycone of hesperidin, it easily passes through the blood-brain barrier into the brain and exerts neuroprotective effects. However, little is known about its neuroprotective effect on emotional memory in aging. To address this issue, we examined the role of hesperetin in the regulation of hippocampal long-term potentiation (LTP), surface expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) including glutamate receptor 1 subunit-containing AMPAR (GluA1) and glutamate receptor 1 subunit-containing AMPAR (GluA2), malondialdehyde (MDA) concentration, reduced glutathione (GSH) concentration, and associative fear memory in aged rats. We found that aged rats exhibited impaired emotional memory and LTP. Furthermore, we also found oral administration of hesperetin ameliorated the impairment of emotional memory and LTP. Finally, we demonstrated hesperetin rescued impaired LTP possibly via enhancing AMPAR trafficking and oxidant-antioxidant balance in aged rats. These results imply a pivotal role for hesperetin in synaptic plasticity and associative fear memory in aged rats and suggest that hesperetin is a potential candidate for treating emotional memory deficit in aging. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
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http://dx.doi.org/10.1037/bne0000475DOI Listing
June 2021

Pediatric living-donor liver transplantation using right posterior segment grafts.

BMC Gastroenterol 2021 Jun 6;21(1):249. Epub 2021 Jun 6.

Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No. 160 Pujian Road, Pudong New District, Shanghai, 200127, China.

Background: The right posterior segment (RPS) graft was introduced to overcome graft size discrepancy in living donor liver transplantation (LDLT). However, it was very rarely used in pediatric patients. Here we presented 4 pediatric LDLT cases receiving RPS graft between January 2015 and April 2020 in our center. A total of 1868 LDLT procedures were performed in this period.

Methods: Recipients included 1 boy and 3 girls with a median age of 45 months (range from 40 to 93 months). They were diagnosed with progressive familial intrahepatic cholestasis, propionic academia, ornithine transcarbamylase and biliary atresia, respectively. Four donors were all mothers with a median age of 32.5 years (31-38 years). Computer tomography angiography indicated posterior right branches branched off separately from main portal veins (type III variation). Three of these donor livers had 1 orifice of right hepatic veins (RHV). In the remaining 1 donor liver, the RHV showed 3 orifices and an outflow patch plastic was performed. Inferior right hepatic veins weren't found in four donor grafts. The median graft weight was 397.5 g (352-461 g) and the median graft-to-recipient weight ratio was 2.38% (1.44-2.80%).

Results: Postoperative complications occurred in neither donors nor recipients. Within the median follow-up duration of 29 months (14-64 months), four children are all alive with normal liver function.

Conclusion: In summary, for older children weighed more than 15 kg with donors' variation of type III portal veins, the use of RPS grafts could be a feasible and favorable option.
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http://dx.doi.org/10.1186/s12876-021-01835-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183075PMC
June 2021

A situational awareness Bayesian network approach for accurate and credible personalized adaptive radiotherapy outcomes prediction in lung cancer patients.

Phys Med 2021 Jul 4;87:11-23. Epub 2021 Jun 4.

Department of Radiation Oncology, The University of Michigan, Ann Arbor, MI, USA.

Purpose: A situational awareness Bayesian network (SA-BN) approach is developed to improve physicians' trust in the prediction of radiation outcomes and evaluate its performance for personalized adaptive radiotherapy (pART).

Methods: 118 non-small-cell lung cancer patients with their biophysical features were employed for discovery (n = 68) and validation (n = 50) of radiation outcomes prediction modeling. Patients' important characteristics identified by radiation experts to predict individual's tumor local control (LC) or radiation pneumonitis with grade ≥ 2 (RP2) were incorporated as expert knowledge (EK). Besides generating an EK-based naïve BN (EK-NBN), an SA-BN was developed by incorporating the EK features into pure data-driven BN (PD-BN) methods to improve the credibility of LC or / and RP2 prediction. After using area under the free-response receiver operating characteristics curve (AU-FROC) to assess the joint prediction of these outcomes, their prediction performances were compared with a regression approach based on the expert yielded estimates (EYE) penalty and its variants.

Results: In addition to improving the credibility of radiation outcomes prediction, the SA-BN approach outperformed the EYE penalty and its variants in terms of the joint prediction of LC and RP2. The value of AU-FROC improves from 0.70 (95% CI: 0.54-0.76) using EK-NBN, to 0.75 (0.65-0.82) using a variant of EYE penalty, to 0.83 (0.75-0.93) using PD-BN and 0.83 (0.77-0.90) using SA-BN; with similar trends in the validation cohort.

Conclusions: The SA-BN approach can provide an accurate and credible human-machine interface to gain physicians' trust in clinical decision-making, which has the potential to be an important component of pART.
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http://dx.doi.org/10.1016/j.ejmp.2021.05.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284560PMC
July 2021

Deformable adversarial registration network with multiple loss constraints.

Comput Med Imaging Graph 2021 May 26;91:101931. Epub 2021 May 26.

Video Processing and Communication Laboratory, Department of Electrical and Computer Engineering, University of Missouri, Columbia, MO 65211, USA.

Deformable medical image registration has the necessary value of theoretical research and clinical application. Traditional methods cannot meet clinical application standards in terms of registration accuracy and efficiency. This article proposes a deformable generate adversarial registration framework, which avoids the dependence on ground-truth deformation. The proposed residual registration network based on Nested U-Net has excellent feature extraction ability and robustness. Multiple constraints that incorporate the potential information of anatomical segmentation extracted by the discriminator can help the model adapt to different modal registration tasks. Through interpatient X-ray chest registration, the deep-supervised training method, and the proposed loss constraint are proved to improve the model's performance and training stability. The experimental results show that our model, compared with state-of-the-art methods, provides a more accurate spatial alignment relationship between different patients' lung organs while ensuring the displacement field's authenticity. Finally, we explored the relationship between the accuracy and validity of the model.
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http://dx.doi.org/10.1016/j.compmedimag.2021.101931DOI Listing
May 2021

Dynamic Imaging and Characterization of Volatile Aerosols in E-Cigarette Emissions Using Deep Learning-Based Holographic Microscopy.

ACS Sens 2021 06 3;6(6):2403-2410. Epub 2021 Jun 3.

Electrical and Computer Engineering Department, University of California, Los Angeles, California 90095, United States.

Various volatile aerosols have been associated with adverse health effects; however, characterization of these aerosols is challenging due to their dynamic nature. Here, we present a method that directly measures the volatility of particulate matter (PM) using computational microscopy and deep learning. This method was applied to aerosols generated by electronic cigarettes (e-cigs), which vaporize a liquid mixture (e-liquid) that mainly consists of propylene glycol (PG), vegetable glycerin (VG), nicotine, and flavoring compounds. E-cig-generated aerosols were recorded by a field-portable computational microscope, using an impaction-based air sampler. A lensless digital holographic microscope inside this mobile device continuously records the inline holograms of the collected particles. A deep learning-based algorithm is used to automatically reconstruct the microscopic images of e-cig-generated particles from their holograms and rapidly quantify their volatility. To evaluate the effects of e-liquid composition on aerosol dynamics, we measured the volatility of the particles generated by flavorless, nicotine-free e-liquids with various PG/VG volumetric ratios, revealing a negative correlation between the particles' volatility and the volumetric ratio of VG in the e-liquid. For a given PG/VG composition, the addition of nicotine dominated the evaporation dynamics of the e-cig aerosol and the aforementioned negative correlation was no longer observed. We also revealed that flavoring additives in e-liquids significantly decrease the volatility of e-cig aerosol. The presented holographic volatility measurement technique and the associated mobile device might provide new insights on the volatility of e-cig-generated particles and can be applied to characterize various volatile PM.
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http://dx.doi.org/10.1021/acssensors.1c00628DOI Listing
June 2021

Nano-Sized Hydroxyapatite Induces Apoptosis and Osteogenic Differentiation of Vascular Smooth Muscle Cells via JNK/c-JUN Pathway.

Int J Nanomedicine 2021 27;16:3633-3648. Epub 2021 May 27.

Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Province, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310009, People's Republic of China.

Purpose: The deposition of hydroxyapatite (HAp) crystals plays an important role in the development of vascular calcification (VC). This study aimed to demonstrate the effects of nanosized HAp (nHAp) on vascular smooth muscle cells (VSMCs) and VC progression.

Methods: Transmission electron microscopy (TEM) was used to examine cellular uptake of nHAp. Cell viability was determined using CCK-8 assay kit. Mitochondrial impairment and reactive oxygen species were detected by TEM and fluorescence dye staining, respectively. Cell apoptosis was detected by Western blot analysis and Annexin V staining. Mouse model of VC was built via applying nHAp on the surface of abdominal aorta. Calcification was visualized by Alizarin red and von Kossa staining.

Results: We found that nHAp could promote osteogenic transformation of VSMCs by elevating expression of runt-related factor 2 (Runx2), osteopontin (OPN) and alkaline phosphatase (ALP), impairing function and morphology of mitochondria and inducing apoptosis of VSMCs. More phosphorylation of c-Jun N-terminal protein kinase/c-JUN (JNK/c-JUN) in VSMCs was detected after mixing nHAp with VSMCs. HAp-induced osteogenic transformation of VSMCs was blocked by JNK inhibitor SP600125, resulted in decreased ALP activity, less Runx2 and OPN expressions. SP600125 also inhibited apoptosis of VSMCs. Application of nHAp to outside of aorta induced osteogenic transformation and apoptosis of VSMCs, and significant deposition of calcium on the vessel walls of mice, which can be effectively attenuated by SP600125.

Conclusion: JNK/c-JUN signaling pathway is critical for nHAp-induced calcification, which could be a potential therapeutic target for controlling the progression of VC.
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http://dx.doi.org/10.2147/IJN.S303714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166281PMC
June 2021

Role of Glycated High Mobility Group Box-1 in Gastric Cancer.

Int J Mol Sci 2021 May 13;22(10). Epub 2021 May 13.

Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.

Advanced glycation end products (AGEs) are produced in response to a high-glucose environment and oxidative stress and exacerbate various diseases. -() (CML) is an AGE that is produced by the glycation of lysine residues of proteins. There are a few reports on alterations in protein function due to CML modification; however, its association with cancer is not clear. We investigated the significance of CML modification in high mobility group box protein-1 (HMGB1), a cytokine that is significantly associated with cancer progression. Treatment of the gastric cancer cell lines TMK1 and MKN74 with glyoxal or glucose resulted in increased CML modification compared to untreated cells. CML-HMGB1 was modified via oxidation and more pronouncedly activated the receptor for AGE and downstream AKT and NF-κB compared to naïve HMGB1 and oxidized HMGB1. CML-HMGB1 bound with reduced affinity to DNA and histone H3, resulting in enhanced extranuclear translocation and extracellular secretion. Treatment of gastric cancer cells with CML-HMGB1 enhanced cell proliferation and invasion, sphere formation, and protection from thapsigargin-induced apoptosis, and decreased 5-FU sensitivity in comparison to HMGB1. Further, CML-HMGB1 was detected at various levels in all the 10 gastric cancer tumor specimens. HMGB1 levels correlated with primary tumor progression and distant metastasis, whereas CML-HMGB1 levels were associated with primary tumor progression, lymph node metastasis, distant metastasis, and stage. In addition, CML-HMGB1 levels correlated with oxidative stress in cancer tissues and resistance to neoadjuvant therapy. Therefore, CML modification of HMGB1 enhanced the cancer-promoting effect of HMGB1. In this study, CML-HMGB1 has been highlighted as a new therapeutic target, and analysis of the molecular structure of CML-HMGB1 is desired in the future.
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http://dx.doi.org/10.3390/ijms22105185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153607PMC
May 2021

Genome-Wide Association Study Identified Novel Candidate Loci/Genes Affecting Lodging Resistance in Rice.

Genes (Basel) 2021 May 11;12(5). Epub 2021 May 11.

Institute of Food Crops, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.

Lodging reduces rice yield, but increasing lodging resistance (LR) usually limits yield potential. Stem strength and leaf type are major traits related to LR and yield, respectively. Hence, understanding the genetic basis of stem strength and leaf type is of help to reduce lodging and increase yield in LR breeding. Here, we carried out an association analysis to identify quantitative trait locus (QTLs) affecting stem strength-related traits (internode length/IL, stem wall thickness/SWT, stem outer diameter/SOD, and stem inner diameter/SID) and leaf type-associated traits (Flag leaf length/FLL, Flag leaf angle/FLA, Flag leaf width/FLW, leaf-rolling/LFR and SPAD/Soil, and plant analyzer development) using a diverse panel of 550 accessions and evaluated over two years. Genome-wide association study (GWAS) using 4,076,837 high-quality single-nucleotide polymorphisms (SNPs) identified 89 QTLs for the nine traits. Next, through "gene-based association analysis, haplotype analysis, and functional annotation", the scope was narrowed down step by step. Finally, we identified 21 candidate genes in 9 important QTLs that included four reported genes (TUT1, OsCCC1, , and ), and seventeen novel candidate genes. Introgression of alleles, which are beneficial for both stem strength and leaf type, or pyramiding stem strength alleles and leaf type alleles, can be employed for LR breeding. All in all, the experimental data and the identified candidate genes in this study provide a useful reference for the genetic improvement of rice LR.
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http://dx.doi.org/10.3390/genes12050718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151605PMC
May 2021

First-Principles Observation of Bonded 2D BC Bilayers.

ACS Omega 2021 May 13;6(20):13218-13224. Epub 2021 May 13.

Department of Theoretical Chemistry and Biology, School of Biotechnology, Royal Institute of Technology, S-106 91 Stockholm, Sweden.

Two-dimensional (2D) B-C compounds possess rich allotropic structures with many applications. Obtaining new 2D BC structures is highly desirable due to the novel applications of three-dimensional (3D) BC in protections. In this work, we proposed a new family of 2D BC from the first-principles calculations. Distinct from previous observations, this family of 2D BC consists of bonded 2D BC bilayers. Six different types of bilayers with distinct bonded structures are found. The phonon spectrum calculations and ab initio molecular dynamics simulations at room temperature demonstrate their dynamic and thermal stabilities. Low formation energies suggest the high possibility of realizing such structures in experiments. Rich electronic structures are found, and the predicted Young's moduli are even higher than those of the previous ones. It is revealed that the unique electronic and mechanical properties are rooted in the bonding structures, indicating the prompting applications of this family of 2D BC materials in photovoltaics, nanoelectronics, and nanomechanics.
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http://dx.doi.org/10.1021/acsomega.1c01073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158795PMC
May 2021
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