Publications by authors named "Yi Du"

311 Publications

High-Efficiency Machine Learning Method for Identifying Foodborne Disease Outbreaks and Confounding Factors.

Foodborne Pathog Dis 2021 Apr 26. Epub 2021 Apr 26.

Computer Network Information Center, Chinese Academy of Sciences, Beijing, China.

The China National Center for Food Safety Risk Assessment (CFSA) uses the Foodborne Disease Monitoring and Reporting System (FDMRS) to monitor outbreaks of foodborne diseases across the country. However, there are problems of underreporting or erroneous reporting in FDMRS, which significantly increase the cost of related epidemic investigations. To solve this problem, we designed a model to identify suspected outbreaks from the data generated by the FDMRS of CFSA. In this study, machine learning models were used to fit the data. The recall rate and F1-score were used as evaluation metrics to compare the classification performance of each model. Feature importance and pathogenic factors were identified and analyzed using tree-based and gradient boosting models. Three real foodborne disease outbreaks were then used to evaluate the best performing model. Furthermore, the SHapley Additive exPlanation value was used to identify the effect of features. Among all machine learning classification models, the eXtreme Gradient Boosting (XGBoost) model achieved the best performance, with the highest recall rate and F1-score of 0.9699 and 0.9582, respectively. In terms of model validation, the model provides a correct judgment of real outbreaks. In the feature importance analysis with the XGBoost model, the health status of the other people with the same exposure has the highest weight, reaching 0.65. The machine learning model built in this study exhibits high accuracy in recognizing foodborne disease outbreaks, thus reducing the manual burden for medical staff. The model helped us identify the confounding factors of foodborne disease outbreaks. Attention should be paid not only to the health status of those with the same exposure but also to the similarity of the cases in time and space.
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http://dx.doi.org/10.1089/fpd.2020.2913DOI Listing
April 2021

Predicting the Risk of Acute Kidney Injury in Patients After Percutaneous Coronary Intervention (PCI) or Cardiopulmonary Bypass (CPB) Surgery: Development and Assessment of a Nomogram Prediction Model.

Med Sci Monit 2021 Apr 25;27:e929791. Epub 2021 Apr 25.

Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan, Shanxi, China (mainland).

BACKGROUND We sought to create a model that incorporated ultrasound examinations to predict the risk of acute kidney injury (AKI) after percutaneous coronary intervention (PCI) or cardiopulmonary bypass (CPB) surgery. MATERIAL AND METHODS A total of 292 patients with AKI after PCI or CPB surgery were enrolled for the study. Afterwards, treatment-related information, including data pertaining to ultrasound examination, was collected. A random forest model and multivariate logistic regression analysis were then used to establish a predictive model for the risk of AKI. Finally, the predictive quality and clinical utility of the model were assessed using calibration plots, receiver-operating characteristic curve, C-index, and decision curve analysis. RESULTS Predictive factors were screened and the model was established with a C-index of 0.955 in the overall sample set. Additionally, an area under the curve of 0.967 was obtained in the training group. Moreover, decision curve analysis also revealed that the prediction model had good clinical applicability. CONCLUSIONS The prediction model was efficient in predicting the risk of AKI by incorporating ultrasound examinations and a number of factors. Such included operation methods, age, congestive heart failure, body mass index, heart rate, white blood cell count, platelet count, hemoglobin, uric acid, and peak intensity (kidney cortex as well as kidney medulla).
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http://dx.doi.org/10.12659/MSM.929791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083792PMC
April 2021

Propofol modulates the proliferation, invasion and migration of bladder cancer cells through the miR‑145‑5p/TOP2A axis.

Mol Med Rep 2021 Jun 13;23(6). Epub 2021 Apr 13.

Department of Anesthesiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China.

Propofol‑based anesthesia has been reported to reduce the recurrence and metastasis of a number of cancer types following surgical resection. However, the effects of propofol in bladder cancer (BC) are yet to be fully elucidated. The aim of the present study was to investigate the functions of propofol in BC and their underlying mechanisms. In the study, the expression of microRNA (miR)‑145‑5p in BC tissues and cell lines was evaluated using reverse transcription‑quantitative PCR, and the effects of propofol on BC cells were determined using cell viability, wound healing and Transwell cell invasion assays, bioinformatics analysis, western blotting, immunohistochemistry and tumor xenograft models. It was found that propofol significantly suppressed the proliferation, migration and invasion of BC cells . In addition, propofol induced miR‑145‑5p expression in a time‑dependent manner, and miR‑145‑5p knockdown attenuated the inhibitory effects of propofol on the proliferation, migration and invasion of BC cells. Topoisomerase II α (TOP2A) was a direct target of miR‑145‑5p, and silencing TOP2A reversed the effects of miR‑145‑5p knockdown in propofol‑treated cells. Furthermore, propofol suppressed tumor xenograft growth, which was partially attenuated by miR‑145‑5p knockdown. The present study provided novel insight into the advantages of surgical intervention with propofol anesthesia in patients with BC.
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http://dx.doi.org/10.3892/mmr.2021.12078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060790PMC
June 2021

Identification and genotoxicity evaluation of potential impurities in rabeprazole sodium using and analyses.

Drug Chem Toxicol 2021 Apr 8:1-7. Epub 2021 Apr 8.

Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China.

Rabeprazole sodium is a widely used drug for gastrointestinal disorders. Several analytical methods for identifying rabeprazole sodium and its impurities have been reported. However, the genotoxicity of rabeprazole sodium and its impurities is still unclear. Thus, it is necessary to develop analytical methods that can identify the structures of its impurities and evaluate their genotoxicity. Here, we used high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry for identifying the impurities in rabeprazole sodium enteric-coated tablets. Impurities in the samples were matched with synthesized impurities based on the exact mass and secondary mass spectrometry characteristics and then subjected to analysis using the Derek and Sarah software, as well as genotoxicity evaluations. Our method successfully identified the impurities as 2-[[4-(3-methoxy propane)-3-methyl-N-oxido-2-pyridyl] methyl sulfonyl]-1H-benzimidazole (impurity I), 2-[[4-(3-methoxy propane)-3-methyl-2-pyridyl]methyl sulfonyl]-benzimidazole (impurity II), 2-[[4-(3-methoxy propane)-3-methyl-2-pyridyl] methionyl]-1H-benzimidazole (impurity III), and 2-mercapto benzimidazole (impurity IV). analysis predicted that impurity III demonstrated a structural alert; thus, this impurity was evaluated for genotoxicity using the Ames test and chromosomal aberration assay. Impurity III at concentrations of 7.5-30 μg/mL had an aberration rate of over 5% with or without S-9 mix. Furthermore, impurity III at concentrations of 40-1000 μg/plate significantly increased the number of mutagenic colonies with or without S-9 mix. These results indicated that impurity III should be regulated to the limit of 0.01%.
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http://dx.doi.org/10.1080/01480545.2021.1908712DOI Listing
April 2021

Recent Advances in Neuromyelitis Optica Spectrum Disorder: Pathogenesis, Mechanisms and Potential Treatments.

Curr Pharm Des 2021 Mar 28. Epub 2021 Mar 28.

National Engineering Laboratory of Southwest Endangered Medicinal Resources Development, Guangxi Botanical Garden of Medicinal Plants, 530023, Nanning. China.

Neuromyelitis optica spectrum disorder (NMOSD) is an acute or subacute demyelinating disease that affects mainly the optic nerve and spinal cord. A major proportion of NMOSD cases have a relationship with autoimmunity to aquaporin 4 (AQP4) found on the central nervous system. NMOSD can occur repeatedly, causing symptoms such as decreased vision and weakness of limbs. The main goal of current therapy is to relieve acute symptoms and prevent recurrence of the disease. Without timely and appropriate treatment, the recurrence and disability rates are high. In the present work, we review recent advances in the diagnosis and treatment of patients with NMOSD, as well as the pathogenesis and mechanisms of AQP4-IgG-seropositive NMOSD.
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http://dx.doi.org/10.2174/1381612827666210329101335DOI Listing
March 2021

Different School Reopening Plans on Coronavirus Disease 2019 Case Growth Rates in the School Setting in the United States.

J Sch Health 2021 May 25;91(5):370-375. Epub 2021 Mar 25.

Senior Epidemiologist/ Research liaison, Epidemiology Informatics, Nebraska Department of Health and Human Service, Lincoln., USA.

Background: In fall 2020, all public K-12 schools reopened in broadly 3 learning models. The hybrid model was considered a mid-risk option compared with remote and in-person learning models. The current study assesses school-based coronavirus disease 2019 (COVID-19) spread in the early fall using a national data set.

Methods: We assess COVID-19 case growth rates from August 10 to October 14, 2020 based on a crowdsourcing data set from the National Education Association. The study follows a retrospective cohort design with the baseline exposures being 3 teaching models: remote learning only, hybrid, and in-person learning. To assess the consistency of our findings, we estimated the overall, as well as region-specific (Northeast, Midwest, South, and West) and poverty-specific (low, mid, and high) COVID-19 case-growth rates. In addition, we validated our study sample using another national sample survey data.

Results: The baseline was from 617 school districts in 48 states, where 47% of school districts were in hybrid, 13% were in remote, and 40% were in-person. Controlling for state-level risk and rural-urban difference, the case growth rates for remote and in-person were lower than the hybrid (odds ratio [OR]: 0.963, 95% confidence interval [CI]: 0.960-0.965 and OR: 0.986, 95% CI: 0.984-0.988, respectively). A consistent result was found among school districts in all 4 regions and each poverty level.

Conclusions: Hybrid may not necessarily be the next logical option when transitioning from the remote to in-person learning models due to its consistent higher case growth rates than the other 2 learning models.
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http://dx.doi.org/10.1111/josh.13009DOI Listing
May 2021

Towards better understanding of the heparin role in NETosis: feasibility of using native mass spectrometry to monitor interactions of neutrophil elastase with heparin oligomers.

Int J Mass Spectrom 2021 May 14;463. Epub 2021 Feb 14.

Chemistry Department, University of Massachusetts-Amherst, Amherst, MA.

Neutrophil elastase is a serine protease released by neutrophils, and its dysregulation has been associated with a variety of debilitating pathologies, most notably cystic fibrosis. This protein is also a prominent component of the so-called neutrophil extracellular traps (NETs), whose formation is a part of the innate immunity response to invading pathogens, but also contributes to a variety of pathologies ranging from autoimmune disorders and inflammation to cancer to thrombotic complications in COVID-19. Retention of neutrophil elastase within NETs is provided by ejected DNA chains, although this protein is also capable of interacting with a range of other endogenous polyanions, such as heparin and heparan sulfate. In this work, we evaluate the feasibility of using native mass spectrometry (MS) as a means of studying interactions of neutrophil elastase with heparin oligomers ranging from structurally homogeneous synthetic pentasaccharide fondaparinux to relatively long (up to twenty saccharide units) and structurally heterogeneous chains produced by partial depolymerization of heparin. The presence of heterogeneous glycan chains on neutrophil elastase and the structural heterogeneity of heparin oligomers render the use of standard MS to study their complexes impractical. However, supplementing MS with limited charge reduction in the gas phase allows meaningful data to be extracted from MS measurements. In contrast to earlier molecular modeling studies where a single heparin-binding site was identified, our work reveals the existence of multiple binding sites, with a single protein molecule being able to accommodate up to three decasaccharides. The measurements also reveal the ability of even relatively short heparin oligomers to bridge two protein molecules, suggesting that characterization of these complexes using native MS can shed light on the structural properties of NETs. Lastly, the use of MS allows the binding preferences of heparin oligomers to neutrophil elastase to be studied with respect to specific structural properties of heparin, such as the level of sulfation ( charge density). All experimental measurements are carried out in parallel with molecular dynamics simulations of the protein/heparin oligomer systems, which are in remarkable agreement with the experimental data and highlight the role of electrostatic interactions as dominant forces governing the formation of these complexes.
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http://dx.doi.org/10.1016/j.ijms.2021.116550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939139PMC
May 2021

Factors Associated with Musculoskeletal Discomfort in Farmers and Ranchers in the U.S. Central States.

J Agromedicine 2021 Apr 29:1-13. Epub 2021 Apr 29.

Department of Environmental, Agricultural and Occupational Health, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Agricultural work involves ergonomic and psychosocial strain, which contribute to musculoskeletal conditions. The aim of this study was to assess if specific ergonomic, psychosocial, and preventive factors are linked to musculoskeletal pain or discomfort symptoms (MSS) in farmers and ranchers. We analyzed data from the Central States Center for Agricultural Safety and Health survey that was conducted in 2018 in a seven-state region of the central United States. MSS were assessed with questions from the Standardized Nordic Questionnaire. The survey included questions on demographic, ergonomic, psychosocial and preventive factors. Farm production variables were added from the Farm Market iD database. We analyzed the data using Generalized Estimating Equations. The overall prevalence of MSS for all body sites combined was 59% among 4,354 farmers and ranchers who responded (19% response rate). After controlling for age, sex, and operator status, three factors (high stress level, sleep deprivation, and exhaustion/fatigue) showed the strongest associations with MSS in any body site, with adjusted odds ratios (OR) ranging from 4.8 to 5.6. Forceful exertions, repetitive tasks, awkward postures, frequent manual labor, and vibration were also significantly associated with MSS, with adjusted ORs ranging from 1.8 to 3.3. Recommended preventive techniques were not protective for MSS. New effective strategies are needed to reduce the high burden of musculoskeletal outcomes among farmers and agricultural workers.
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http://dx.doi.org/10.1080/1059924X.2021.1893880DOI Listing
April 2021

Identification of close relationship between atmospheric oxidation and ozone formation regimes in a photochemically active region.

J Environ Sci (China) 2021 Apr 21;102:373-383. Epub 2020 Oct 21.

Climate, Environment and Sustainability Center, Nanjing University of Information Science and Technology, Nanjing 210044, China.

Understanding ozone (O) formation regime is a prerequisite in formulating an effective O pollution control strategy. Photochemical indicator is a simple and direct method in identifying O formation regimes. Most used indicators are derived from observations, whereas the role of atmospheric oxidation is not in consideration, which is the core driver of O formation. Thus, it may impact accuracy in signaling O formation regimes. In this study, an advanced three-dimensional numerical modeling system was used to investigate the relationship between atmospheric oxidation and O formation regimes during a long-lasting O exceedance event in September 2017 over the Pearl River Delta (PRD) of China. We discovered a clear relationship between atmospheric oxidative capacity and O formation regime. Over eastern PRD, O formation was mainly in a NO-limited regime when HO/OH ratio was higher than 11, while in a VOC-limited regime when the ratio was lower than 9.5. Over central and western PRD, an HO/OH ratio higher than 5 and lower than 2 was indicative of NO-limited and VOC-limited regime, respectively. Physical contribution, including horizontal transport and vertical transport, may pose uncertainties on the indication of O formation regime by HO/OH ratio. In comparison with other commonly used photochemical indicators, HO/OH ratio had the best performance in differentiating O formation regimes. This study highlighted the necessities in using an atmospheric oxidative capacity-based indicator to infer O formation regime, and underscored the importance of characterizing behaviors of radicals to gain insight in atmospheric processes leading to O pollution over a photochemically active region.
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http://dx.doi.org/10.1016/j.jes.2020.09.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575429PMC
April 2021

[Effect of acupuncture on knee injury and osteoarthritis outcome score in patients with knee osteoarthritis].

Zhongguo Zhen Jiu 2021 Jan;41(1):27-30

International Acupuncture and Moxibustion Innovation Institute, Beijing University of CM, Beijing 100029, China; School of Acupuncture-Moxibustion and Tuina, Beijing University of CM, Beijing 100029.

Objective: To verify the clinical effect of acupuncture on knee osteoarthritis (KOA).

Methods: Forty-two patients with KOA were randomly divided into an acupuncture group (21 cases, 1 case dropped off) and a sham acupuncture group (21 cases, 1 case dropped off). The patients in the acupuncture group were treated with routine acupuncture at 5-6 local acupoints [Dubi (ST 35), Neixiyan (EX-LE 4), Heding (EX-LE 2), Yinlingquan (SP 9), Xuehai (SP 10), Zusanli (ST 36), etc.] and 3-4 distal acupoints [Fengshi (GB 31), Waiqiu (GB 36), Xuanzhong (GB 39), Zulinqi (GB 41), etc.]. The patients in the sham acupuncture group were treated with shallow needling technique at non-acupoint. The needles were retained for 30 min in both groups. All the treatment was given three times a week for 8 weeks. Knee injury and osteoarthritis outcome score (KOOS) were recorded before and after treatment and 18-week follow-up.

Results: Compared before treatment, the scores of 5 dimensions of KOOS [pain, symptoms (except pain), daily activities, sports and entertainment, and quality of life] were increased after treatment and during follow-up in the two groups (<0.05), and the scores of pain and daily activities in the acupuncture group were higher than those in the sham acupuncture group (<0.05).

Conclusion: Acupuncture can reduce the pain symptoms and improve daily activities in patients with KOA.
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http://dx.doi.org/10.13703/j.0255-2930.20191212-0001DOI Listing
January 2021

Trimethylamine N-oxide mediated Y-box binding protein-1 nuclear translocation promotes cell cycle progression by directly downregulating Gadd45a expression in a cellular model of chronic kidney disease.

Life Sci 2021 Apr 5;271:119173. Epub 2021 Feb 5.

Department of Nephrology, Shanghai General Hospital, Nanjing Medical University, No.100 Haining Road, Hongkou District, Shanghai, China; Department of Nephrology, Shanghai General Hospital, No.100 Haining Road, Hongkou District, Shanghai, China. Electronic address:

Aims: Cell cycle arrest plays critical roles in preventing renal tubular epithelial cell (RTEC) injury and maladaptation after the onset of chronic kidney disease (CKD), but the underlying mechanism governing this arrest has not been fully elucidated. This study was designed to determine the underlying role of YB-1 in promoting cell cycle progression and nuclear translocation in HK-2 cells induced by trimethylamine N-oxide (TMAO).

Main Methods: YB-1 primarily accumulated in the cytoplasm in HK-2 cells after they were treated with TMAO for 30 min and 6 h. Gene expression was analysed using RNA sequencing in HK-2 cells treated with TMAO. Cell cycle progression was analysed via flow cytometry. Luciferase assay and ChIP-PCR were performed to determine the relationship between transcription factor YB-1 and Gadd45a promoter region. Additionally, mice were fed with TMAO to test renal dysfunction and measure the expression of YB-1, GADD45a and CCNA2 in the kidney sections through immunohistochemistry.

Key Findings: YB-1 primarily accumulated in the cytoplasm in HK-2 cells after they were treated with TMAO for 30 min and 6 h. RNA sequencing analysis showed that the cell cycle checkpoint genes growth arrest and DNA damage (Gadd)45a, Gadd45g, cyclin (Ccn)a2, Ccnb1, Ccne1 and Ccnf were differentially expressed in HK-2 cells after treated with 400 μM TMAO for 30 min. Flow cytometry results demonstrated that cell cycle progression was blocked at the G2/M checkpoint. In animal models, elevated dietary TMAO directly led to progressive renal tubulointerstitial dysfunction and inhibited the expression of YB-1 in kidney. Moreover, YB-1 was determined to regulate Gadd45a expression by directly binding to its promoter region. YB-1 expression was negatively correlated with the expression of Gadd45a and Gadd45g but positively correlated with Ccna2, Ccnb1, Ccne1 and Ccnf in CKD.

Significance: YB-1 may be a reliable molecular target and an effective prognostic biomarker for CKD.
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http://dx.doi.org/10.1016/j.lfs.2021.119173DOI Listing
April 2021

General Programmable Growth of Hybrid Core-Shell Nanostructures with Liquid Metal Nanodroplets.

Adv Mater 2021 Mar 1;33(11):e2008024. Epub 2021 Feb 1.

Institute for Superconducting and Electronic Materials (ISEM), Australian Institute for Innovative Materials (AIIM), University of Wollongong, Wollongong, NSW, 2500, Australia.

Core-shell and hollow nanostructures have been receiving significant interest due to their potential in wide scientific and technological fields. Given such large scope, however, they still lag far behind in terms of the ambition toward controllably, or even programmatically, synthesizing libraries of core-shell structures on a large scale. Here, a general route for the programmable preparation of complex core-shell nanostructures by using liquid metal (LM) droplets as reformable templates is presented, and the triggering of a localized galvanic replacement reaction in one ultrasonication system is demonstrated. Benefiting from the activity and mobility of the metal components in LM templates, high-level compositional diversity control and quantitative regulation of both the core and the shell layers of the heterogeneous products are achieved, which cannot be realized with a solid-template synthetic route.
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http://dx.doi.org/10.1002/adma.202008024DOI Listing
March 2021

Shining light on transition metal sulfides: New choices as highly efficient antibacterial agents.

Nano Res 2021 Jan 21:1-23. Epub 2021 Jan 21.

Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of Education, Shandong University, Jinan, 250061 China.

Globally, millions of people die of microbial infection-related diseases every year. The more terrible situation is that due to the overuse of antibiotics, especially in developing countries, people are struggling to fight with the bacteria variation. The emergence of super-bacteria will be an intractable environmental and health hazard in the future unless novel bactericidal weapons are mounted. Consequently, it is critical to develop viable antibacterial approaches to sustain the prosperous development of human society. Recent researches indicate that transition metal sulfides (TMSs) represent prominent bactericidal application potential owing to the meritorious antibacterial performance, acceptable biocompatibility, high solar energy utilization efficiency, and excellent photo-to-thermal conversion characteristics, and thus, a comprehensive review on the recent advances in this area would be beneficial for the future development. In this review article, we start with the antibacterial mechanisms of TMSs to provide a preliminary understanding. Thereafter, the state-of-the-art research progresses on the strategies for TMSs materials engineering so as to promote their antibacterial properties are systematically surveyed and summarized, followed by a summary of the practical application scenarios of TMSs-based antibacterial platforms. Finally, based on the thorough survey and analysis, we emphasize the challenges and future development trends in this area.
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http://dx.doi.org/10.1007/s12274-021-3293-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818700PMC
January 2021

Machine Learning Prediction of Foodborne Disease Pathogens: Algorithm Development and Validation Study.

JMIR Med Inform 2021 Jan 26;9(1):e24924. Epub 2021 Jan 26.

Computer Network Information Center, Chinese Academy of Sciences, Beijing, China.

Background: Foodborne diseases, as a type of disease with a high global incidence, place a heavy burden on public health and social economy. Foodborne pathogens, as the main factor of foodborne diseases, play an important role in the treatment and prevention of foodborne diseases; however, foodborne diseases caused by different pathogens lack specificity in clinical features, and there is a low proportion of clinically actual pathogen detection in real life.

Objective: We aimed to analyze foodborne disease case data, select appropriate features based on analysis results, and use machine learning methods to classify foodborne disease pathogens to predict foodborne disease pathogens that have not been tested.

Methods: We extracted features such as space, time, and exposed food from foodborne disease case data and analyzed the relationship between these features and the foodborne disease pathogens using a variety of machine learning methods to classify foodborne disease pathogens. We compared the results of 4 models to obtain the pathogen prediction model with the highest accuracy.

Results: The gradient boost decision tree model obtained the highest accuracy, with accuracy approaching 69% in identifying 4 pathogens including Salmonella, Norovirus, Escherichia coli, and Vibrio parahaemolyticus. By evaluating the importance of features such as time of illness, geographical longitude and latitude, and diarrhea frequency, we found that they play important roles in classifying the foodborne disease pathogens.

Conclusions: Data analysis can reflect the distribution of some features of foodborne diseases and the relationship among the features. The classification of pathogens based on the analysis results and machine learning methods can provide beneficial support for clinical auxiliary diagnosis and treatment of foodborne diseases.
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http://dx.doi.org/10.2196/24924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872834PMC
January 2021

Perioperative transcutaneous electrical acupoint stimulation for improving postoperative gastrointestinal function: A randomized controlled trial.

J Integr Med 2021 Jan 13. Epub 2021 Jan 13.

Department of Traditional Chinese Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

Background: Postoperative gastrointestinal dysfunction (PGD) is one of the most common complications in patients undergoing major abdominal surgery. Acupuncture has been used widely in gastrointestinal diseases due to its effectiveness and minimally invasive nature.

Objective: This study evaluated the efficacy of using transcutaneous electrical acupoint stimulation (TEAS) during the surgery and postoperative recovery in patients with gastric and colorectal surgery for improving postoperative gastrointestinal function.

Design, Setting, Participants And Interventions: A total of 280 patients undergoing abdominal surgery were stratified by type of surgery (i.e., gastric or colorectal surgery) and randomly allocated into the TEAS group (group T) or the sham group (group S). Patients in group T received TEAS at LI4, PC6, ST36 and ST37. Patients in group S received pseudo-TEAS at sham acupoints. The stimulation was given from 30 min before anesthesia until the end of surgery. The same treatment was performed at 9 am on the 1st, 2nd and 3rd days after surgery, until the recovery of flatus in patients.

Main Outcome Measures: The primary outcome was the time to the first bowel motion, as detected by auscultation. The secondary outcomes included the first flatus and ambulation time, changes of perioperative substance P (SP), incidence of PGD, postoperative pain, postoperative nausea and vomiting (PONV) and some economic indicators.

Results: The time to first bowel motion, first flatus and first ambulation in group T was much shorter than that in group S (P < 0.01). In patients undergoing colorectal surgery, the concentration of SP was lower in group T than in group S on the third day after the operation (P < 0.05). The average incidence of PGD in all patients was 25%, and the frequency of PGD was significantly lower in group T than in group S (18.6% vs. 31.4%, respectively; P < 0.05). TEAS treatment (odds ratio = 0.498; 95% confidence interval: 0.232-0.786) and type of surgery were relevant factors for the development of PGD. Postoperative pain score and PONV occurrence were significantly lower in group T (P < 0.01). Postoperative hospitalization days and the resulting cost to patients were greatly reduced in the TEAS group (P < 0.01).

Conclusion: Perioperative TEAS was able to promote the recovery of postoperative gastrointestinal function, reduce the incidence of PGD and PONV. The concentration of SP was decreased by TEAS treatment, which indicates that the brain-gut axis may play a role in how TEAS regulates gastrointestinal function.

Trial Registration: Chinese Clinical Trial Registry, ChiCTR1900023263.
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http://dx.doi.org/10.1016/j.joim.2021.01.005DOI Listing
January 2021

Incidence of omental metastasis in uterine serous carcinoma: study protocol for a systematic review and meta-analysis.

BMJ Open 2021 01 17;11(1):e043141. Epub 2021 Jan 17.

Department of Obstetrics and Gynaecology, Sichuan University West China Second University Hospital, Chengdu, Sichuan, China

Introduction: Uterine serous carcinoma accounts for only about 10% of all endometrial cancers but this subtype is the most common amongst non-endometrioid endometrium cancers and contributes to more than half of recurrence and deaths attributed to endometrial cancers. A more extensive surgical staging and adjuvant therapies for uterine serous carcinoma are recommended by many guidelines. However, guidelines vary on recommendations for the methods that should be used for omentum assessment in uterine serous carcinoma and the previously reported incidence of omental metastasis in uterine serous carcinoma had a wide range because of the heterogeneity among these studies. As far as we know, there are no systematic review and meta-analysis available on this topic. The aim of our proposed study is to statistically synthesise the data examining the incidence of omental metastasis in uterine serous carcinoma.

Methods And Analysis: Systematic searches of three databases (PubMed, Embase and Web of Science) will be performed using prespecified search strategies. We will include original studies that reported incidence of omental metastasis in uterine serous carcinoma and are published before 30 August 2020. Our different investigators will independently conduct the eligible study selection, assess the quality of included studies and extract the needed data. If appropriate, the relevant data will be pooled through a random-effect or fixed-effect meta-analysis based on the heterogeneity among included studies. We will evaluate the overall quality of evidence using appropriate methods.

Ethics And Dissemination: This proposed study will be based on published data, and thus, there is no requirement for ethics approval. We aim to publish the results of this study in a peer-reviewed journal with good visibility for the fields of gynaecology and gynecologic oncology.

Prospero Registration Number: CRD42020200891.
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http://dx.doi.org/10.1136/bmjopen-2020-043141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813338PMC
January 2021

Combinatorial Modulation of Linalool Synthase and Farnesyl Diphosphate Synthase for Linalool Overproduction in .

J Agric Food Chem 2021 Jan 11;69(3):1003-1010. Epub 2021 Jan 11.

Institute of Bioengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, PR China.

Linalool, as a fragrant monoterpene, is an important feedstock for food, pharmaceuticals, and cosmetics industries. Although our previous study had significantly increased linalool production by the directed evolution of linalool synthase and overexpression of the whole mevalonate pathway genes, the engineered yeast strain suffered from dramatically reduced biomass. Herein, a stress-free linalool-producing yeast cell factory was constructed by the combinational regulation of linalool synthase and farnesyl diphosphate synthase instead of multienzyme overexpression. First, the expression level of linalool synthase was successfully enhanced by introducing a N-terminal SKIK tag, which improved linalool production by 3.3-fold. Subsequently, the modular assembly of linalool synthase and dominant negative farnesyl diphosphate synthase via short peptide tags efficiently converted geranyl pyrophosphate to linalool. Additional downregulation of the native farnesyl diphosphate synthase led to the highest reported linalool production (80.9 mg/L) in yeast. This combinatorial modulation strategy may also be applied to the production of other high-value monoterpenes.
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http://dx.doi.org/10.1021/acs.jafc.0c06384DOI Listing
January 2021

Wheat heat tolerance is impaired by heightened deletions in the distal end of 4AL chromosomal arm.

Plant Biotechnol J 2020 Dec 28. Epub 2020 Dec 28.

College of Agronomy, State Key Laboratory of Wheat and Maize Crop Science, and Center for Crop Genome Engineering, Henan Agricultural University, Zhengzhou, China.

Heat stress (HS) causes substantial damages to worldwide crop production. As a cool season crop, wheat (Triticum aestivum) is sensitive to HS-induced damages. To support the genetic improvement of wheat HS tolerance (HST), we conducted fine mapping of TaHST1, a locus required for maintaining wheat vegetative and reproductive growth under elevated temperatures. TaHST1 was mapped to the distal terminus of 4AL chromosome arm using genetic populations derived from two BC F breeding lines showing tolerance (E6015-4T) or sensitivity (E6015-3S) to HS. The 4AL region carrying TaHST1 locus was approximately 0.949 Mbp and contained the last 19 high confidence genes of 4AL according to wheat reference genome sequence. Resequencing of E6015-3S and E6015-4T and haplotype analysis of 3087 worldwide wheat accessions revealed heightened deletion polymorphisms in the distal 0.949 Mbp region of 4AL, which was confirmed by the finding of frequent gene losses in this region in eight genome-sequenced hexaploid wheat cultivars. The great majority (86.36%) of the 3087 lines displayed different degrees of nucleotide sequence deletions, with only 13.64% of them resembling E6015-4T in this region. These deletions can impair the presence and/or function of TaHST1 and surrounding genes, thus rendering global wheat germplasm vulnerable to HS or other environmental adversities. Therefore, conscientious and urgent efforts are needed in global wheat breeding programmes to optimize the structure and function of 4AL distal terminus by ensuring the presence of TaHST1 and surrounding genes. The new information reported here will help to accelerate the ongoing global efforts in improving wheat HST.
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http://dx.doi.org/10.1111/pbi.13529DOI Listing
December 2020

Ambulatory blood pressure is better associated with target organ damage than clinic blood pressure in patients with primary glomerular disease.

BMC Nephrol 2020 12 11;21(1):541. Epub 2020 Dec 11.

Division of Nephrology, Department of Medicine, the Third affiliated hospital Sun Yat-Sen University, GuangZhou, 510000, Guangdong, China.

Background: Blood pressure is an important and modifiable cardiovascular risk factor. Ambulatory blood pressure monitoring (ABPM) provides valuable prognostic information in patients with chronic kidney disease (CKD), yet little is known about the association of various types of BP measurements with target organ damage (TOD) in patients with primary glomerular disease. The goal of this study was to investigate whether ambulatory blood pressure is better associated with TOD than clinic blood pressure in patients with primary glomerular disease.

Methods: 1178 patients with primary glomerular disease were recruited in this cross-sectional study. TOD were assessed by the following 4 parameters: left ventricular mass index (LVMI or LVH, left ventricular hypertrophy), estimated glomerular filtration rate (eGFR< 60 ml/min/1.73m), albumin-to-creatinine ratio (ACR ≥ 30 mg/g) and carotid intima-media thickness (cIMT) or plaque. Receiver operating characteristic (ROC) curve and multivariate logistic regression analyses were used to evaluate the relationship between ambulatory or clinic systolic blood pressure (SBP) indexes and TOD.

Results: Among 1178 patients (mean age, 39 years,54% men), 116, 458, 1031 and 251 patients had LVH, eGFR < 60 ml/min/1.73m, ACR ≥ 30 mg/g and cIMT≥0.9 mm or plaque respectively. Area under ROC curves for TOD in ambulatory SBP, especially nighttime SBP, was greater than that in clinic SBP (P < 0.05). Multivariate logistic regression analyses showed that 24 h SBP, daytime SBP and nighttime SBP were significantly associated with LVH, eGFR< 60 ml/min/1.73m and ACR ≥ 30 mg/g after adjustment for clinic SBP, while the association of clinic SBP was attenuated after further adjustment for nighttime SBP.

Conclusions: Ambulatory blood pressure, especially nighttime blood pressure, is probably superior to clinic blood pressure and has a significant association with TOD in primary glomerular disease patients.
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http://dx.doi.org/10.1186/s12882-020-02200-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731761PMC
December 2020

Oncological safety of hysteroscopy in the diagnosis of stage I endometrial cancer: protocol for a systematic review and meta-analysis.

BMJ Open 2020 12 10;10(12):e041981. Epub 2020 Dec 10.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China

Background: The oncological safety of diagnostic hysteroscopy in patients with stage Ⅰ endometrial cancer remains uncertain and conflicting. The aim of the proposed systematic review and meta-analysis is to summarise the available evidence examining the association between diagnostic hysteroscopy and the prognosis of stage Ⅰ endometrial cancer and to statistically synthesise the results of relevant studies.

Methods And Analysis: Systematic searches of PubMed/MEDLINE, Embase, Cochrane Library and Web of Science will be undertaken using prespecified search strategies. Two authors will independently conduct eligible studies selection process, perform data extraction and appraise the quality of included studies. Original case-control studies, cohort studies and randomised controlled trails published in English will be considered for inclusion. The outcomes of interest will be 5-year recurrence-free survival, disease-specific survival and overall survival. Meta-analyses will be performed to calculate pooled estimates.

Ethics And Dissemination: Our study will be based on published data, and thus there is no requirement for ethics approval. The results will be shared through publication in a peer-reviewed journal and presentations at academic conferences.

Prospero Registration Number: CRD42020193696.
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http://dx.doi.org/10.1136/bmjopen-2020-041981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733216PMC
December 2020

TP53-Associated Ion Channel Genes Serve as Prognostic Predictor and Therapeutic Targets in Head and Neck Squamous Cell Carcinoma.

Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820972344

Department of Endodontics, Jinan Stomatological Hospital, Jinan, Shandong, China.

TP53 mutations are the most occurred mutation in HNSCC which might affect the ion channel genes. We aim to investigate the ion channel gene alteration under TP53 mutation and their prognostic implication. The overall mutation status of HNSCC were explored. By screening the TP53-associated ion channel genes (TICGs), an ion channel prognostic signature (ICPS) was established through a series of machine learning algorithms. The ICPS was then evaluated and its clinical significance was explored. 82 TICGs differentially expressed between TP53WT and TP53MUT were screened. Using univariate regression analysis and LASSO regression analysis and multivariate regression analysis, an ICPS containing 7 ion channel genes was established. A series of evaluation was carried out which proved the predictive ability of ICPS. Functional analysis of ICPS revealed that cancer-related pathways were enriched in high-risk group. Next, for clinical application, a nomogram was constructed based on ICPS and other independent clinicopathological factors. TP53 mutation status strongly affects the expression of ion channel genes. The ICPM we have identified is a strong indicator for HNSCC prognosis and could help with patient stratification as well as identification of novel drug targets.
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http://dx.doi.org/10.1177/1533033820972344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705194PMC
November 2020

Incidence and risk factors for postoperative venous thromboembolism in patients with ovarian cancer: Systematic review and meta-analysis.

Gynecol Oncol 2021 Feb 19;160(2):610-618. Epub 2020 Nov 19.

Department of Obstetrics and Gynaecology, West China Second University Hospital, Sichuan University, Chengdu, China. Electronic address:

Background: Venous Thromboembolism (VTE) is a leading cause of morbidity and mortality in patients with ovarian malignancy. There is no meta-analysis available on this topic so far. The aim of our study was to quantitatively synthesize the data from studies with respect to the incidence and risk factors for postoperative VTE among cases with epithelial ovarian cancer (EOC).

Methods: PubMed, Web of Science, and Embase were searched for papers containing the key words "venous thromboembolism", "postoperative", "postoperation", "ovarian neoplasm", "ovary neoplasm", "ovarian cancer", "ovary cancer", and "cancer of ovary". Studies selection, data extraction, quality assessment of eligible studies were performed independently by our different reviewers. Meta-analyses were conducted to determine postoperative VTE incidence and risk factors in women with EOC. Sensitivity analysis were used to verify the robustness of the results of meta-analyses if necessary.

Results: In total, 19 studies were included in this meta-analysis. The pooled incidence for postoperative symptomatic VTE was 3% (95% CI, 0.03-0.04) and for postoperative symptomatic as well as asymptomatic VTE was 8% (95% CI, 0.07-0.09). The presence of history of VTE (OR, 2.37), advanced-stages (OR, 2.35), high complexity of surgery (OR, 2.20), clear cell carcinoma of ovary (OR, 2.53) and residual disease>1 cm (OR, 2.57) significantly increase the likelihood of having postoperative VTE. Other risk factors for postoperative VTE in EOC patients were BMI>30 (OR, 1.58), per 10-years increase in age (OR, 1.22), ASA score>2 (OR, 1.45), ascites (OR, 2.07), the diameter of residual disease is between 0 cm to 1 cm (OR, 2.06) and smoking history (OR, 1.54).

Conclusions: This study revealed that VTE, especially subclinical VTE, is a prevalent complication in postoperative patients with EOC. History of VTE, advanced FIGO stages, high complexity of surgery, obesity, older age, ascites, higher ASA score, smoking history and suboptimal debulking are associated with this increased incidence of postoperative VTE among patients with EOC. PROSPERO registration number: CRD42020209662.
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http://dx.doi.org/10.1016/j.ygyno.2020.11.010DOI Listing
February 2021

Directed evolution of the transcription factor Gal4 for development of an improved transcriptional regulation system in Saccharomyces cerevisiae.

Enzyme Microb Technol 2020 Dec 28;142:109675. Epub 2020 Sep 28.

Institute of Bioengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, PR China. Electronic address:

As a well-characterized eukaryotic DNA binding transcription factor, Gal4 has been extensively employed to construct controllable gene expression systems in Saccharomyces cerevisiae. The problem of insufficient inducibility arises in the constructs with multiples genes under control of GAL promoters due to the low expression level and activity of the native Gal4. In order to obtain improved transcriptional regulation systems for multi-gene pathways, Gal4 mutants with improved activity were created by directed evolution. During the preliminary screening, five positive Gal4 variants were isolated based on the lycopene-indicated high-throughput screening method. Analysis of the mutation sites revealed that the majority of positive mutations are localized in the middle homology region with unspecified function, suggesting an important role of this domain in transactivation of Gal4. Through combinatorial site-directed mutagenesis, the best variant Gal4 was obtained, which successfully increased the transcription of P-driven lycopene pathway genes and led to 48 % higher lycopene accumulation relative to the wild-type Gal4. This study demonstrates the viability of modifying Gal4 activity by directed evolution for elevated expression of P-driven genes and therefore enhanced production of the target metabolite.
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http://dx.doi.org/10.1016/j.enzmictec.2020.109675DOI Listing
December 2020

Critical period and pathways of water borne nitrogen loss from a rice paddy in northeast China.

Sci Total Environ 2021 Jan 7;753:142116. Epub 2020 Sep 7.

College of Resources, Environment, and Tourism, Capital Normal University, Beijing 100048, China.

Rice paddy nitrogen (N) loss is a great concern leading to a high risk of receiving water pollution. Various models have been applied as practical tools for simulation of the nutrient loss amount, and pathways or yield change affected by management factors in previous studies. However, N loss features of rice paddies in northern regions have received less attention and few model simulation studies have combined crop yield and N loss to simultaneously meet the needs of yield maintenance and environmental protection. To consider benefits to local farmers and to assess the paddy N loss features and factors in northeast China, rice yields and water borne N losses in 2013-2017 were simulated using the APSIM-Oryza model applied to Xingkai Lake Farm. Different from subtropical regions, high field ridges and lower rainfall limit local paddy overflow occurrence except after unexpected storms after irrigation in dry years or serial rainfall events, which result in subsurface N loss during stages of tillering (Ti) to flowering (Fl) which comprise the dominant pathway accounting for 50.03-69.99% of the total water borne N loss. The correlation analysis results also indicate irrigation and the applied N amount more significantly affect local paddy N loss than does precipitation. In each year, stimulated by an increase in the applied N amount, increasing rice yield (symbolizing crop growth status) indicated N loss implicitly rose. But under similar applied N amount range, inter-annual N loss results showed weaker growth status result in a higher N loss. Based on local N loss features, nutrient conservation practices including planting density increase or side strip application, and net N loss reduction practices including intermittent or recycling irrigation are recommended to limit nutrient loss from a paddy field which would be helpful for optimization of local nutrient conservation and surrounding water environment protection.
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http://dx.doi.org/10.1016/j.scitotenv.2020.142116DOI Listing
January 2021

1, 6-O, O-Diacetylbritannilactone from Induces Anti-Tumor Effect on Oral Squamous Cell Carcinoma via miR-1247-3p/LXRα/ABCA1 Signaling.

Onco Targets Ther 2020 29;13:11097-11109. Epub 2020 Oct 29.

Department of Stomatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xian City, Shanxi Province 710061, People's Republic of China.

Introduction: Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy affecting the oral cavity and is associated with severe morbidity and high mortality. 1, 6-O, O-Diacetylbritannilactone (OODBL) isolated from the medicinal herb of has various biological activities such as anti-inflammation and anti-cancer. However, the effect of OODBL on OSCC progression remains unclear. Here, we were interested in the function of OODBL in the development of OSCC.

Methods: The effect of OODBL on OSCC progression was analyzed by MTT assays, colony formation assays, transwell assays, apoptosis analysis, cell cycle analysis, and in vivo tumorigenicity analysis. The mechanism investigation was performed by qPCR assays, Western blot analysis, and luciferase reporter gene assays.

Results: We found that OODBL inhibits the proliferation of OSCC cells in vitro. Moreover, the migration and invasion were attenuated by OODBL treatment in the OSCC cells. OODBL arrested cells at the G0/G1 phase and induced cell apoptosis. OODBL was able to up-regulate the expression of LXRα, ABCA1, and ABCG1 in the system. In addition, OODBL activated LXRα/ABCA1 signaling by targeting miR-1247-3p. Furthermore, the expression levels of cytochrome c in the cytoplasm, cleaved caspase-9, and cleaved caspase-3 were dose-dependently reduced by OODBL. Besides, OODBL increased the expression ratio of Bax to Bcl-2. Moreover, OODBL repressed tumor growth of OSCC cells in vivo.

Discussion: Thus, we conclude that OODBL inhibits OSCC progression by modulating miR-1247-3p/LXRα/ABCA1 signaling. Our finding provides new insights into the mechanism by which OODBL exerts potent anti-tumor activity against OSCC. OODBL may be a potential anti-tumor candidate, providing a novel clinical treatment strategy of OSCC.
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http://dx.doi.org/10.2147/OTT.S263014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605651PMC
October 2020

Promoted Photocharge Separation in 2D Lateral Epitaxial Heterostructure for Visible-Light-Driven CO Photoreduction.

Adv Mater 2020 Dec 29;32(48):e2004311. Epub 2020 Oct 29.

Institute for Superconducting and Electronic Materials (ISEM), Australian Institute for Innovative Materials (AIIM), University of Wollongong, Wollongong, New South Wales, 2500, Australia.

Photocarrier recombination remains a big barrier for the improvement of solar energy conversion efficiency. For 2D materials, construction of heterostructures represents an efficient strategy to promote photoexcited carrier separation via an internal electric field at the heterointerface. However, due to the difficulty in seeking two components with suitable crystal lattice mismatch, most of the current 2D heterostructures are vertical heterostructures and the exploration of 2D lateral heterostructures is scarce and limited. Here, lateral epitaxial heterostructures of BiOCl @ Bi O at the atomic level are fabricated via sonicating-assisted etching of Cl in BiOCl. This unique lateral heterostructure expedites photoexcited charge separation and transportation through the internal electric field induced by chemical bonding at the lateral interface. As a result, the lateral BiOCl @ Bi O heterostructure demonstrates superior CO photoreduction properties with a CO yield rate of about 30 µmol g h under visible light illumination. The strategy to fabricate lateral epitaxial heterostructures in this work is expected to provide inspiration for preparing other 2D lateral heterostructures used in optoelectronic devices, energy conversion, and storage fields.
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http://dx.doi.org/10.1002/adma.202004311DOI Listing
December 2020

Control of Photocarrier Separation and Recombination at Bismuth Oxyhalide Interface for Nitrogen Fixation.

J Phys Chem Lett 2020 Nov 21;11(21):9304-9312. Epub 2020 Oct 21.

Institute for Superconducting and Electronic Materials (ISEM), Australian Institute for Innovative Materials (AIIM), University of Wollongong, Wollongong, New South Wales 2500, Australia.

Developing high-efficiency photocatalysts for clean energy generation is a grand challenge, which requires simultaneously steering photocarrier dynamics and chemical activity for a specific reaction. To this end, here for the first time, we explore the real-time photocarrier transport property and catalytic mechanism of nitrogen reduction reaction (NRR) at the interface of bismuth oxyhalides (BiOX, X = Cl, Br, and I), an inexpensive and green semiconductor. By time-dependent non-adiabatic molecular dynamics simulations, we show that the separation and recombination processes of excited carriers as well as the catalytic activity can be concurrently optimized by precise band structure engineering. The exact influence of impurity states and heterojunction on the reduction power and lifetime of photogenerated carriers, light absorbance, and NRR activity/selectivity of BiOX are clearly unveiled, to provide essential physical insights for improving the photocatalytic efficiency of semiconductors for practical solar energy conversion and hydrogen fuel storage.
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http://dx.doi.org/10.1021/acs.jpclett.0c02480DOI Listing
November 2020

Air and bone-conducted vestibular evoked myogenic potentials in children with large vestibular aqueduct syndrome.

Acta Otolaryngol 2021 Jan 23;141(1):50-56. Epub 2020 Sep 23.

College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China.

Background: There are few studies focused on vestibular symptoms and function of the children with LVAS.

Objectives: This study aimed to find the characteristics of air and bone-conducted VEMPs among children with LVAS, and to investigate the relationship between VEMPs and vestibular symptoms.

Material And Methods: A total of 44 children with LVAS and 10 healthy children were recruited as the case group and control group. Air and bone-conducted VEMP were performed to the participants.

Results: For air-conducted measurement, there was elevated amplitude of cVEMP in case group than control group. There was no significant difference at oVEMP parameters between the case group and control group. For bone-conducted measurement, significantly longer P1 latency and shorter P1-N1 latency of cVEMP were observed among the case group; there were a series of changes in oVEMP parameters among the case group. Logistic regression model revealed that air-conducted oVEMP asymmetric ratio was valuable to predict vestibular symptoms' development among the kids with LVAS.

Conclusion: Asymmetric ratio of oVEMP could be used as one predictor of developing vestibular symptoms of the children with LVAS. Applying bone-conducted VEMP as one alternative parameter of vestibular syndrome is novel and will certainly remain an area of continued investigation.
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http://dx.doi.org/10.1080/00016489.2020.1815836DOI Listing
January 2021

Chinese Herbal Formula Xuefu Zhuyu for Stable Angina (CheruSA): Study Protocol for a Multicenter Randomized Controlled Trial.

Evid Based Complement Alternat Med 2020 31;2020:7612721. Epub 2020 Aug 31.

Key Unit of Methodology in Clinical Research, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.

Stable angina (SA) in coronary heart disease is a common ischemic heart disease endangering the patient's quality of life and longevity. Clinical trials have demonstrated that the Chinese herbal formula Xuefu Zhuyu (XFZY) has benefits for SA patients. However, there remains a lack of high-quality evidence to support clinical decision-making. Therefore, we designed a randomized controlled trial (RCT) to evaluate the efficacy and safety of XFZY for SA. This multicenter, double-blinded RCT will be conducted in China. 152 eligible participants will be randomly assigned to either an XFZY group or a control group at a 1 : 1 ratio. Participants in the XFZY group will receive XFZY plus routine care, while those in the control group will receive placebo plus routine care. The study period is 26 weeks, including a 2-week run-in period, a 12-week treatment period, and a 12-week follow-up. The primary outcome is the change in visual analogue scale score for angina pain intensity from baseline to 12 weeks. The secondary outcomes are the angina attack frequency and duration, the nitroglycerin dosage consumed, the Canadian Cardiovascular Society grading of effort angina, the Seattle Angina Questionnaire, the EuroQol-5-Dimensions-5-Level, the incidence of major adverse cardiac events, health cost evaluation, and overall assessment for study drugs. The study has been approved by the ethics committee of Guangdong Provincial Hospital of Chinese Medicine (approval no. BF2019-175-01). Results will be submitted for publication in peer-reviewed journals and disseminated at scientific conferences. This trial is registered with ChiCTR1900026899, registered on 26 October 2019.
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http://dx.doi.org/10.1155/2020/7612721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479468PMC
August 2020

The characteristics of vHIT gain and PR score in peripheral vestibular disorders.

Acta Otolaryngol 2021 Jan 15;141(1):43-49. Epub 2020 Sep 15.

College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China.

Background: Clinical application of vHIT is limited due to a lack of interpretation of vHIT gain and saccades.

Objectives: This research focuses on comparing common vertigo diseases on vHIT gain and saccade divergence(PR score).

Material And Methods: We retrospectively reviewed 165 patients who have one definite diagnosis, good data quality, and can be read by MATLAB software. All patients were grouped into unilateral vestibular dysfunction (UVD), Meniere's disease (MD), vestibular migraine (VM), Ramsay Hunt Syndrome (RHS), bilateral vestibular hypofunction (BVH), benign paroxysmal positional vertigo (BPPV), and acoustic neuroma (AN). PR score was calculated by an open-source software HitCal.

Results: The saccade detection rate is higher than the abnormal vHIT gain on UVD, MD, VM, RHS, BVH and BPPV. PR score combined with vHIT gain could separate the affected side in UVD and RHS. In the MD group, both vHIT gain and PR score have inconspicuous performance. We also found that different compensation levels and hearing loss status affect results.

Conclusions And Significance: vHIT gain combined with PR score enables a proper distinction among common vertigo diseases. PR score is more sensitive than the gain value on evaluating the physiological situation, vestibular compensation and disease progression.
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http://dx.doi.org/10.1080/00016489.2020.1812715DOI Listing
January 2021