Publications by authors named "Yeon-Gu Kim"

35Publications

Amplification of EBNA-1 through a single-plasmid vector-based gene amplification system in HEK293 cells as an efficient transient gene expression system.

Appl Microbiol Biotechnol 2020 Nov 16. Epub 2020 Nov 16.

Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, Korea.

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http://dx.doi.org/10.1007/s00253-020-11001-3DOI Listing
November 2020

Ischemia-induced Netrin-4 promotes neovascularization through endothelial progenitor cell activation via Unc-5 Netrin receptor B.

FASEB J 2020 01 29;34(1):1231-1246. Epub 2019 Nov 29.

Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, South Korea.

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http://dx.doi.org/10.1096/fj.201900866RRDOI Listing
January 2020

Two distinct cellular pathways leading to endothelial cell cytotoxicity by silica nanoparticle size.

J Nanobiotechnology 2019 Feb 5;17(1):24. Epub 2019 Feb 5.

Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.

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http://dx.doi.org/10.1186/s12951-019-0456-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362579PMC
February 2019

Ginkgetin, a biflavone from Ginkgo biloba leaves, prevents adipogenesis through STAT5-mediated PPARγ and C/EBPα regulation.

Pharmacol Res 2019 01 22;139:325-336. Epub 2018 Nov 22.

Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea; Department of Biomolecular Science, University of Science & Technology (UST), Daejeon, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183073
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http://dx.doi.org/10.1016/j.phrs.2018.11.027DOI Listing
January 2019

Differential expression of microRNAs in recombinant Chinese hamster ovary cells treated with sodium butyrate using digital RNA counting.

J Biotechnol 2018 Oct 18;283:37-42. Epub 2018 Jul 18.

Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, South Korea; Department of Bioprocess Engineering, KRIBB School of Biotechnology, Korea University of Science and Technology (UST), 217 Gajeong-ro, Yuseong-gu, Daejeon, South Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01681656183055
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http://dx.doi.org/10.1016/j.jbiotec.2018.07.018DOI Listing
October 2018

DSG2 Is a Functional Cell Surface Marker for Identification and Isolation of Human Pluripotent Stem Cells.

Stem Cell Reports 2018 07 14;11(1):115-127. Epub 2018 Jun 14.

Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Korea; Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology (UST), 217 Gajeong-ro, Yuseong-gu, Daejeon 34141, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117473PMC
July 2018

Co-amplification of EBNA-1 and PyLT through dhfr-mediated gene amplification for improving foreign protein production in transient gene expression in CHO cells.

Appl Microbiol Biotechnol 2018 Jun 13;102(11):4729-4739. Epub 2018 Apr 13.

Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, South Korea.

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http://link.springer.com/10.1007/s00253-018-8977-6
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http://dx.doi.org/10.1007/s00253-018-8977-6DOI Listing
June 2018

Understanding of decreased sialylation of Fc-fusion protein in hyperosmotic recombinant Chinese hamster ovary cell culture: N-glycosylation gene expression and N-linked glycan antennary profile.

Biotechnol Bioeng 2017 08 30;114(8):1721-1732. Epub 2017 Mar 30.

Department of Biological Sciences, KAIST, 335 Gwahak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea.

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http://doi.wiley.com/10.1002/bit.26284
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http://dx.doi.org/10.1002/bit.26284DOI Listing
August 2017

A novel regulatory element (E77) isolated from CHO-K1 genomic DNA enhances stable gene expression in Chinese hamster ovary cells.

Biotechnol J 2016 May 11;11(5):633-41. Epub 2016 Feb 11.

Department of Bioprocess Engineering, Korea University of Science and Technology (UST), Daejeon, Republic of Korea.

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http://dx.doi.org/10.1002/biot.201500464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067685PMC
May 2016

A single-plasmid vector for transgene amplification using short hairpin RNA targeting the 3'-UTR of amplifiable dhfr.

Appl Microbiol Biotechnol 2015 Dec 6;99(23):10117-26. Epub 2015 Aug 6.

Department of Bioprocess Engineering, Korea University of Science and Technology (UST), 217 Gajeong-ro, Yuseong-gu, Daejeon, 305-350, Republic of Korea.

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http://dx.doi.org/10.1007/s00253-015-6856-yDOI Listing
December 2015

Effect of Bcl-xL overexpression on sialylation of Fc-fusion protein in recombinant Chinese hamster ovary cell cultures.

Biotechnol Prog 2015 Jul-Aug;31(4):1133-6. Epub 2015 Jun 26.

Dept. of Biological Sciences, KAIST, Daejeon, 305-701, Republic of Korea.

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http://dx.doi.org/10.1002/btpr.2115DOI Listing
May 2016

Understanding of altered N-glycosylation-related gene expression in recombinant Chinese hamster ovary cells subjected to elevated ammonium concentration by digital mRNA counting.

Biotechnol Bioeng 2015 Aug 10;112(8):1583-93. Epub 2015 Mar 10.

Department of Biological Sciences, KAIST, 335 Gwaha k-ro, Yuseong-gu, Daejeon, 305-701, Republic of Korea.

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http://dx.doi.org/10.1002/bit.25568DOI Listing
August 2015

Monitoring change in refractive index of cytosol of animal cells on affinity surface under osmotic stimulus for label-free measurement of viability.

Biosens Bioelectron 2015 Feb 6;64:241-6. Epub 2014 Sep 6.

Nanobiotechnology Major, Korea University of Science and Technology, 52 Eoeun-Dong, Yuseong-Gu, Daejeon 305-333, Republic of Korea; Korea Research Institute of Bioscience and Biotechnology, 52 Eoeun-Dong, Yuseong-Gu, Daejeon 305-333, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bios.2014.09.007DOI Listing
February 2015

Effect of lithium chloride on the production and sialylation of Fc-fusion protein in Chinese hamster ovary cell culture.

Appl Microbiol Biotechnol 2014 Nov 19;98(22):9239-48. Epub 2014 Aug 19.

Department of Biological Sciences, KAIST, 335 Gwahak-ro, Yuseong-gu, Daejeon, 305-701, South Korea,

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http://dx.doi.org/10.1007/s00253-014-6012-0DOI Listing
November 2014

Digital mRNA profiling of N-glycosylation gene expression in recombinant Chinese hamster ovary cells treated with sodium butyrate.

J Biotechnol 2014 Feb 12;171:56-60. Epub 2013 Dec 12.

Department of Biological Sciences, KAIST, 373-1 Kusong-Dong, Yusong-Gu, Daejon 305-701, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jbiotec.2013.12.001DOI Listing
February 2014

Gamma-aminobutyric acid production using immobilized glutamate decarboxylase followed by downstream processing with cation exchange chromatography.

Int J Mol Sci 2013 Jan 15;14(1):1728-39. Epub 2013 Jan 15.

University of Science and Technology (UST), 217 Gajeong-ro, Yuseong-gu, Daejeon 305-350, Korea.

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http://dx.doi.org/10.3390/ijms14011728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565344PMC
January 2013

An efficient strategy for cell-based antibody library selection using an integrated vector system.

BMC Biotechnol 2012 Sep 18;12:62. Epub 2012 Sep 18.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, 111 Gwahangno, Yuseong-gu, Daejon 305-806, Republic of Korea.

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http://dx.doi.org/10.1186/1472-6750-12-62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505469PMC
September 2012

Differential in-gel electrophoresis (DIGE) analysis of CHO cells under hyperosmotic pressure: osmoprotective effect of glycine betaine addition.

Biotechnol Bioeng 2012 Jun 23;109(6):1395-403. Epub 2012 Jan 23.

Department of Biological Sciences, Graduate School of Nanoscience and Technology (WCU), KAIST, 373-1 Kusong-Dong, Yusong-Gu, Daejon 305-701, Korea.

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http://doi.wiley.com/10.1002/bit.24442
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http://dx.doi.org/10.1002/bit.24442DOI Listing
June 2012

CHO cells in biotechnology for production of recombinant proteins: current state and further potential.

Appl Microbiol Biotechnol 2012 Feb 9;93(3):917-30. Epub 2011 Dec 9.

Department of Biological Sciences, Graduate School of Nanoscience & Technology (WCU), KAIST, 373-1 Kusong-Dong, Yuseong-Gu, Daejeon 305-701, Korea.

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http://www.springerlink.com/index/365m3646q2n3036t.pdf
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http://link.springer.com/content/pdf/10.1007/s00253-011-3758
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http://dx.doi.org/10.1007/s00253-011-3758-5DOI Listing
February 2012

Bcl-x(L) overexpression delays the onset of autophagy and apoptosis in hyperosmotic recombinant Chinese hamster ovary cell cultures.

J Biotechnol 2011 Oct 3;156(1):52-5. Epub 2011 Aug 3.

Department of Biological Sciences, Graduate School of Nanoscience & Technology, KAIST, 373-1 Kusong-Dong, Yusong-gu, Daejon 305-701, Republic of Korea.

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http://dx.doi.org/10.1016/j.jbiotec.2011.07.032DOI Listing
October 2011

Effect of constitutively active Ras overexpression on cell growth in recombinant Chinese hamster ovary cells.

Biotechnol Prog 2011 Mar-Apr;27(2):577-80. Epub 2011 Mar 25.

Department of Biological Sciences, Graduate School of Nanoscience and Technology (WCU), KAIST, Daejon 305-701, Korea.

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http://dx.doi.org/10.1002/btpr.567DOI Listing
September 2011

Proteomic understanding of intracellular responses of recombinant Chinese hamster ovary cells cultivated in serum-free medium supplemented with hydrolysates.

Appl Microbiol Biotechnol 2011 Mar 1;89(6):1917-28. Epub 2011 Feb 1.

Department of Biological Sciences and Graduate School of Nanoscience & Technology (WCU), KAIST, Yuseong-Gu, Daejon, South Korea.

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http://dx.doi.org/10.1007/s00253-011-3106-9DOI Listing
March 2011

Hyperosmotic stress induces autophagy and apoptosis in recombinant Chinese hamster ovary cell culture.

Biotechnol Bioeng 2010 Apr;105(6):1187-92

Department of Biological Sciences, Graduate School of Nanoscience & Technology (WCU), KAIST, 373-1 Kusong-Dong, Yusong-Gu, Daejon, Korea.

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http://doi.wiley.com/10.1002/bit.22643
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http://dx.doi.org/10.1002/bit.22643DOI Listing
April 2010

A proteomic approach for identifying cellular proteins interacting with erythropoietin in recombinant Chinese hamster ovary cells.

Biotechnol Prog 2010 Jan-Feb;26(1):246-51

Dept. of Biological Sciences, KAIST, 373-1, Kusong-Dong, Yusong-Gu, Daejon 305-701, Korea.

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http://doi.wiley.com/10.1002/btpr.323
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http://dx.doi.org/10.1002/btpr.323DOI Listing
May 2010

Effect of XIAP overexpression on sodium butyrate-induced apoptosis in recombinant Chinese hamster ovary cells producing erythropoietin.

J Biotechnol 2009 Dec 30;144(4):299-303. Epub 2009 Sep 30.

Department of Biological Sciences and Graduate School of Nanoscience & Technology (WCU), KAIST, 373-1 Kusong-Dong, Yusong-Gu, Daejon 305-701, Republic of Korea.

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http://linkinghub.elsevier.com/retrieve/pii/S016816560900423
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http://dx.doi.org/10.1016/j.jbiotec.2009.09.016DOI Listing
December 2009

Effect of Bcl-xL overexpression on apoptosis and autophagy in recombinant Chinese hamster ovary cells under nutrient-deprived condition.

Biotechnol Bioeng 2009 Jul;103(4):757-66

Department of Biological Sciences, KAIST, 373-1 Kusong-Dong, Yusong-Gu, Daejon, Korea.

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http://doi.wiley.com/10.1002/bit.22298
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http://dx.doi.org/10.1002/bit.22298DOI Listing
July 2009

Bcl-xL overexpression does not enhance specific erythropoietin productivity of recombinant CHO cells grown at 33 degrees C and 37 degrees C.

Biotechnol Prog 2009 Jan-Feb;25(1):252-6

Dept. of Biological Sciences, KAIST, 373-1 Kusong-Dong, Yusong-Gu, Daejon 305-701, Korea.

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http://dx.doi.org/10.1002/btpr.91DOI Listing
April 2009

Assessment of cell engineering strategies for improved therapeutic protein production in CHO cells.

Biotechnol J 2008 May;3(5):624-30

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejon, Korea.

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http://doi.wiley.com/10.1002/biot.200700249
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http://dx.doi.org/10.1002/biot.200700249DOI Listing
May 2008

Biochemical characterization of a recombinant Japanese encephalitis virus RNA-dependent RNA polymerase.

BMC Mol Biol 2007 Jul 11;8:59. Epub 2007 Jul 11.

Department of Biotechnology, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul, Korea.

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http://dx.doi.org/10.1186/1471-2199-8-59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934914PMC
July 2007

Down-regulation of cold-inducible RNA-binding protein does not improve hypothermic growth of Chinese hamster ovary cells producing erythropoietin.

Metab Eng 2007 Mar 15;9(2):208-16. Epub 2006 Dec 15.

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373-1 Kusong-Dong, Yusong-Gu, Daejon 305-701, Korea.

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http://dx.doi.org/10.1016/j.ymben.2006.11.003DOI Listing
March 2007

New thermophilic and thermostable esterase with sequence similarity to the hormone-sensitive lipase family, cloned from a metagenomic library.

Appl Environ Microbiol 2005 Feb;71(2):817-25

Department of Biotechnology, Yonsei University, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-749, Korea.

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http://dx.doi.org/10.1128/AEM.71.2.817-825.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC546692PMC
February 2005

Protein kinase C-related kinase 2 regulates hepatitis C virus RNA polymerase function by phosphorylation.

J Biol Chem 2004 Nov 13;279(48):50031-41. Epub 2004 Sep 13.

Department of Biotechnology, Yonsei University, Seoul 120-749, Korea.

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http://dx.doi.org/10.1074/jbc.M408617200DOI Listing
November 2004

Biochemical properties of full-length hepatitis C virus RNA-dependent RNA polymerase expressed in insect cells.

Exp Mol Med 2003 Dec;35(6):475-85

Department of Biotechnology, Yonsei University, 134 Sinchon-dong, Seodaemun-gu Seoul 120-749, Korea.

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http://dx.doi.org/10.1038/emm.2003.62DOI Listing
December 2003