Yen-Hsu Chen

Yen-Hsu Chen

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Regulation of hyaluronan biosynthesis and clinical impact of excessive hyaluronan production.

Matrix Biol 2019 05 31;78-79:100-117. Epub 2018 Jan 31.

Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26110 Patras, Greece.

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http://dx.doi.org/10.1016/j.matbio.2018.01.017DOI Listing
May 2019

Molecular epidemiology of the emerging ceftriaxone resistant non-typhoidal Salmonella in southern Taiwan.

J Microbiol Immunol Infect 2019 Apr 27;52(2):289-296. Epub 2018 Aug 27.

Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Clinical Microbiology, Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1016/j.jmii.2018.08.007DOI Listing
April 2019

Implementation of a national quality improvement program to enhance hand hygiene in nursing homes in Taiwan.

J Microbiol Immunol Infect 2019 Apr 28;52(2):345-351. Epub 2018 Sep 28.

Infection Control Center, Chi-Mei Medical Center, Tainan, Taiwan; Department of Nursing, College of Medicine and Life Sciene, Chung Hwa University of Medical Technology, Tainan, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S16841182183041
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http://dx.doi.org/10.1016/j.jmii.2018.09.007DOI Listing
April 2019

Using groEL as the target for identification of Enterococcus faecium clades and 7 clinically relevant Enterococcus species.

J Microbiol Immunol Infect 2019 Apr 14;52(2):255-264. Epub 2018 Nov 14.

Department of Microbiology and Immunology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S16841182183048
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http://dx.doi.org/10.1016/j.jmii.2018.10.008DOI Listing
April 2019

Essential Role of Visfatin in Lipopolysaccharide and Colon Ascendens Stent Peritonitis-Induced Acute Lung Injury.

Int J Mol Sci 2019 Apr 4;20(7). Epub 2019 Apr 4.

Translational Research Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

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http://dx.doi.org/10.3390/ijms20071678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480124PMC
April 2019

Effect of Anti-CD4 Antibody UB-421 on HIV-1 Rebound after Treatment Interruption.

N Engl J Med 2019 04;380(16):1535-1545

From United Biomedical, Hauppauge, NY (C.-Y.W., B.-S.K., C.L.F., F.W.-S.); United Biomedical Asia (C.-Y.W., S.L.) and United BioPharma (C.-Y.W., B.-S.K., H.-W.S., C.-Y.L., F.-C.T., A.L., F.-H.Y., C.-H.L., W.T., M.-J.L.), Hsinchu, Taipei Veterans General Hospital, Taipei (W.-W.W., H.-Y.L.), and Kaohsiung Veterans General Hospital (H.-C.T.) and Kaohsiung Medical University Hospital (Y.-H.C.), Kaohsiung - all in Taiwan; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (J.B., K.E.C., T.-W.C.); and the California Department of Public Health, Richmond (C.V.H.).

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http://www.nejm.org/doi/10.1056/NEJMoa1802264
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http://dx.doi.org/10.1056/NEJMoa1802264DOI Listing
April 2019

Characteristics of scrub typhus, murine typhus, and Q fever among elderly patients: Prolonged prothrombin time as a predictor for severity.

J Microbiol Immunol Infect 2019 Feb 22;52(1):54-61. Epub 2017 Jun 22.

School of Medicine, Kaohsiung Medical University, Taiwan; Division of Infectious Disease, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jmii.2016.08.023DOI Listing
February 2019

Three months of rifapentine and isoniazid for latent tuberculosis infection in hemodialysis patients: High rates of adverse events.

J Microbiol Immunol Infect 2019 Feb 2;52(1):158-162. Epub 2018 Jun 2.

Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; School of Medicine, Graduate Institute of Medicine, Sepsis Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsin Chu, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jmii.2018.05.003DOI Listing
February 2019

Clinical characteristics of Candida tropicalis fungaemia with reduced triazole susceptibility in Taiwan: a multicentre study.

Int J Antimicrob Agents 2019 Feb 27;53(2):185-189. Epub 2018 Oct 27.

Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2018.10.015DOI Listing
February 2019

Microbiology of peritoneal dialysis-related infection and factors of refractory peritoneal dialysis related peritonitis: A ten-year single-center study in Taiwan.

J Microbiol Immunol Infect 2019 Jan 8. Epub 2019 Jan 8.

Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan; College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsin Chu, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jmii.2018.10.013DOI Listing
January 2019

Resistance rates of non- infections in Taiwan after the revision of 2012 Clinical and Laboratory Standards Institute breakpoints.

Infect Drug Resist 2019 15;12:235-240. Epub 2019 Jan 15.

Division of Infectious Disease, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan,

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http://dx.doi.org/10.2147/IDR.S184884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338119PMC
January 2019

Infections Caused by Carbapenem-Resistant : An Update on Therapeutic Options.

Front Microbiol 2019 30;10:80. Epub 2019 Jan 30.

Department of Laboratory Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.3389/fmicb.2019.00080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363665PMC
January 2019

Metformin is associated with a lower risk of active tuberculosis in patients with type 2 diabetes.

Respirology 2018 Nov 25;23(11):1063-1073. Epub 2018 Jun 25.

Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1111/resp.13338DOI Listing
November 2018

Clinical characteristics of patients with bacteraemia due to the emergence of mcr-1-harbouring Enterobacteriaceae in humans and pigs in Taiwan.

Int J Antimicrob Agents 2018 Nov 24;52(5):651-657. Epub 2018 Aug 24.

Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.ijantimicag.2018.08.015DOI Listing
November 2018

Two fatal cases of Aeromonas dhakensis bacteremia and necrotizing fasciitis in severe dengue patients.

J Microbiol Immunol Infect 2018 Oct 18;51(5):692-694. Epub 2018 May 18.

Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1016/j.jmii.2018.03.003DOI Listing
October 2018

Capnocytophaga sputigena pneumonia and bacteremia in a patient with diabetes and gastric cancer.

J Microbiol Immunol Infect 2018 Aug 19;51(4):578-579. Epub 2017 Dec 19.

Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; School of Medicine, Graduate Institute of Medicine, Sepsis Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, HsinChu, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jmii.2017.11.005DOI Listing
August 2018

QuantiFERON-TB Gold Plus Is a More Sensitive Screening Tool than QuantiFERON-TB Gold In-Tube for Latent Tuberculosis Infection among Older Adults in Long-Term Care Facilities.

J Clin Microbiol 2018 08 26;56(8). Epub 2018 Jul 26.

Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan

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http://dx.doi.org/10.1128/JCM.00427-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062801PMC
August 2018

AIDS-related opportunistic illnesses and early initiation of HIV care remain critical in the contemporary HAART era: a retrospective cohort study in Taiwan.

BMC Infect Dis 2018 07 28;18(1):352. Epub 2018 Jul 28.

Division of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Rd., Kaohsiung, 813, Taiwan.

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http://dx.doi.org/10.1186/s12879-018-3251-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064097PMC
July 2018

Corrigendum to "Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)" [J Microbiol Immunol Infect 49 (2016) 969-976].

J Microbiol Immunol Infect 2018 Jun 17;51(3):423-424. Epub 2017 Mar 17.

Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Laboratory Medicine, School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jmii.2017.01.001DOI Listing
June 2018

The epidemiology, antibiograms and predictors of mortality among critically-ill patients with central line-associated bloodstream infections.

J Microbiol Immunol Infect 2018 Jun 6;51(3):401-410. Epub 2017 Sep 6.

Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1016/j.jmii.2017.08.016DOI Listing
June 2018

Are we ready for the global emergence of multidrug-resistant Candida auris in Taiwan?

J Formos Med Assoc 2018 Jun 6;117(6):462-470. Epub 2017 Nov 6.

Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.jfma.2017.10.005DOI Listing
June 2018

Levels of malondialdehyde in the gastric juice: Its association with Helicobacter pylori infection and stomach diseases.

Helicobacter 2018 Apr 5;23(2):e12460. Epub 2018 Jan 5.

Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1111/hel.12460DOI Listing
April 2018

Management of infections caused by extended-spectrum β-lactamase-producing Enterobacteriaceae: current evidence and future prospects.

Expert Rev Anti Infect Ther 2018 03 9;16(3):205-218. Epub 2018 Feb 9.

e Department of Laboratory Medicine , National Taiwan University Hospital, College of Medicine, National Taiwan University , Taipei , Taiwan.

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http://dx.doi.org/10.1080/14787210.2018.1436966DOI Listing
March 2018

Resistance to first- and second-line antituberculosis drugs in Southern Taiwan: Implications for empirical treatment.

J Microbiol Immunol Infect 2018 Feb 29;51(1):88-93. Epub 2017 Jun 29.

Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan; College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S16841182173011
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http://dx.doi.org/10.1016/j.jmii.2017.05.008DOI Listing
February 2018

Simple Strategy for Rapid and Sensitive Detection of Avian Influenza A H7N9 Virus Based on Intensity-Modulated SPR Biosensor and New Generated Antibody.

Anal Chem 2018 02 25;90(3):1861-1869. Epub 2018 Jan 25.

Center for Infectious Disease and Cancer Research, Kaohsiung Medical University , Kaohsiung 80708, Taiwan.

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http://dx.doi.org/10.1021/acs.analchem.7b03934DOI Listing
February 2018

National bundle care program implementation to reduce ventilator-associated pneumonia in intensive care units in Taiwan.

J Microbiol Immunol Infect 2017 Dec 1. Epub 2017 Dec 1.

Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jmii.2017.11.001DOI Listing
December 2017

Lipopolysaccharide-Induced Nitric Oxide, Prostaglandin E2, and Cytokine Production of Mouse and Human Macrophages Are Suppressed by Pheophytin-b.

Int J Mol Sci 2017 Dec 6;18(12). Epub 2017 Dec 6.

Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.

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http://www.mdpi.com/1422-0067/18/12/2637
Publisher Site
http://dx.doi.org/10.3390/ijms18122637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751240PMC
December 2017

Role of rifampin for the treatment of bacterial infections other than mycobacteriosis.

J Infect 2017 11 1;75(5):395-408. Epub 2017 Sep 1.

Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2017.08.013DOI Listing
November 2017

Epidemiology and antifungal susceptibility of candidemia isolates of non-albicans Candida species from cancer patients.

Emerg Microbes Infect 2017 Oct 11;6(10):e87. Epub 2017 Oct 11.

Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan.

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http://dx.doi.org/10.1038/emi.2017.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658770PMC
October 2017

Implementation of a national bundle care program to reduce catheter-associated urinary tract infection in high-risk units of hospitals in Taiwan.

J Microbiol Immunol Infect 2017 Aug 26;50(4):464-470. Epub 2017 Jun 26.

Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jmii.2017.01.006DOI Listing
August 2017

Development of a Simple Clinical Risk Score for Early Prediction of Severe Dengue in Adult Patients.

PLoS One 2016 3;11(5):e0154772. Epub 2016 May 3.

Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, 833, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0154772PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854400PMC
July 2017

IL-28 and IL-29 as protective markers in subject with dengue fever.

Med Microbiol Immunol 2017 Jun 25;206(3):217-223. Epub 2017 Feb 25.

Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China.

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http://dx.doi.org/10.1007/s00430-017-0498-xDOI Listing
June 2017

Epidemiology and trends in the antibiotic susceptibilities of Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region, 2010-2013.

Int J Antimicrob Agents 2017 Jun 20;49(6):734-739. Epub 2017 Apr 20.

Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2017.01.030DOI Listing
June 2017

Discovery of Indeno[1,2-c]quinoline Derivatives as Potent Dual Antituberculosis and Anti-Inflammatory Agents.

Molecules 2017 Jun 16;22(6). Epub 2017 Jun 16.

Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

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http://dx.doi.org/10.3390/molecules22061001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152673PMC
June 2017

Incidence of autoimmune diseases in a nationwide HIV/AIDS patient cohort in Taiwan, 2000-2012.

Ann Rheum Dis 2017 04 2;76(4):661-665. Epub 2016 Sep 2.

Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1136/annrheumdis-2016-209815DOI Listing
April 2017

A nationwide covert observation study using a novel method for hand hygiene compliance in health care.

Am J Infect Control 2017 Mar 9;45(3):240-244. Epub 2016 Nov 9.

Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ajic.2016.10.010DOI Listing
March 2017

Schisandrin A inhibits dengue viral replication via upregulating antiviral interferon responses through STAT signaling pathway.

Sci Rep 2017 03 24;7:45171. Epub 2017 Mar 24.

Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1038/srep45171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364541PMC
March 2017

Identification of factors for physicians to facilitate early differential diagnosis of scrub typhus, murine typhus, and Q fever from dengue fever in Taiwan.

J Microbiol Immunol Infect 2017 Feb 26;50(1):104-111. Epub 2014 Dec 26.

School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Tropical Medicine Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Tropical Medicine Research Center, College of Medicine, Kaohsiung Medical University, Taiwan; Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

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https://linkinghub.elsevier.com/retrieve/pii/S16841182140025
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http://dx.doi.org/10.1016/j.jmii.2014.12.001DOI Listing
February 2017

Reactivated cytomegalovirus proctitis in an immunocompetent patient presenting as nosocomial diarrhea: a case report and literature review.

BMC Infect Dis 2017 02 1;17(1):113. Epub 2017 Feb 1.

Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1186/s12879-017-2218-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286859PMC
February 2017

Consecutive large dengue outbreaks in Taiwan in 2014-2015.

Emerg Microbes Infect 2016 Dec 7;5(12):e123. Epub 2016 Dec 7.

Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.

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http://dx.doi.org/10.1038/emi.2016.124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180368PMC
December 2016

Clinical outcomes of septic patients with diabetic ketoacidosis between 2004 and 2013 in a tertiary hospital in Taiwan.

J Microbiol Immunol Infect 2016 Oct 4;49(5):663-671. Epub 2014 Nov 4.

Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1016/j.jmii.2014.08.018DOI Listing
October 2016

CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis.

J Mol Med (Berl) 2016 09 31;94(9):1025-37. Epub 2016 Mar 31.

Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan.

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http://dx.doi.org/10.1007/s00109-016-1409-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992505PMC
September 2016

An Underestimated Co-infection: Swine Influenza and Pneumonia Due to Legionella pneumophila.

Am J Med Sci 2016 Sep 22;352(3):314-6. Epub 2016 Apr 22.

School of Medicine, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.amjms.2016.04.010DOI Listing
September 2016

Human heme oxygenase 1 is a potential host cell factor against dengue virus replication.

Sci Rep 2016 08 24;6:32176. Epub 2016 Aug 24.

Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1038/srep32176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995454PMC
August 2016

Recent developments in antibiotic agents for the treatment of complicated intra-abdominal infections.

Expert Opin Pharmacother 2016 18;17(3):339-54. Epub 2015 Dec 18.

e Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, College of Medicine , National Taiwan University , Taipei , Taiwan.

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http://dx.doi.org/10.1517/14656566.2016.1122756DOI Listing
July 2016

HCV NS5A Up-Regulates COX-2 Expression via IL-8-Mediated Activation of the ERK/JNK MAPK Pathway.

PLoS One 2015 31;10(7):e0133264. Epub 2015 Jul 31.

Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133264PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521820PMC
May 2016

A Rapid and Accurate Method to Evaluate Helicobacter pylori Infection, Clarithromycin Resistance, and CYP2C19 Genotypes Simultaneously From Gastric Juice.

Medicine (Baltimore) 2016 May;95(21):e3458

From the Division of Gastroenterology, Department of Internal Medicine (C-HK, C-JL, H-MH, H-YS, M-CW, D-CW), Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Medicine, Faculty of Medicine, College of Medicine (C-HK, H-MH, Y-HC, D-CW), Kaohsiung Medical University, Kaohsiung, Taiwan; Center for Stem Cell Research (C-HK, H-MW, D-CW), Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Microbiology and Immunology (C-CY, L-LC), Kaohsiung Medical University, Kaohsiung, Taiwan; School of Medicine, College of Medicine (F-CK), E-Da Hospital, I-Shou University, Kaohsiung, Taiwan; Department of Internal Medicine (H-YS, M-CW, D-CW), Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan; Division of Infectious Diseases, Department of Internal Medicine (Y-HC), Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Fragrance and Cosmetic Science (H-MW), Kaohsiung Medical University, Kaohsiung, Taiwan; and Department of Gastroenterology (J-LR), Zhongshan Hospital affiliated to Xiamen University, Xiamen, Fujian, China; Center for Infectious Disease and Cancer Research (D-CW), Kaohsiung Medical University, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1097/MD.0000000000003458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902335PMC
May 2016

Serum Galectin-9 and Galectin-3-Binding Protein in Acute Dengue Virus Infection.

Int J Mol Sci 2016 May 27;17(6). Epub 2016 May 27.

Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

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http://dx.doi.org/10.3390/ijms17060832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926366PMC
May 2016

New drugs for the treatment of complicated intra-abdominal infections in the era of increasing antimicrobial resistance.

Int J Antimicrob Agents 2016 Apr 21;47(4):250-8. Epub 2016 Feb 21.

Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University, College of Medicine, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2015.12.021DOI Listing
April 2016

Effects of various antimicrobial stewardship programs on antimicrobial usage and resistance among common gram-negative bacilli causing health care-associated infections: A multicenter comparison.

J Microbiol Immunol Infect 2016 Feb 27;49(1):74-82. Epub 2015 Jun 27.

School of Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Infectious Diseases, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address:

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February 2016

Severe Dengue Fever Outbreak in Taiwan.

Am J Trop Med Hyg 2016 Jan 16;94(1):193-7. Epub 2015 Nov 16.

Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan; Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Infection Disease, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Gastroenterology, Department of Internal Medicine Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan; Department of Microbiology and Immunology, College of Medicine, Kaohsiung Medical, University, Kaohsiung, Taiwan; Center for Dengue Fever Control and Research, Kaohsiung Medical University, Kaohsiung, Taiwan

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http://dx.doi.org/10.4269/ajtmh.15-0422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710429PMC
January 2016

One dose versus three weekly doses of benzathine penicillin G for patients co-infected with HIV and early syphilis: a multicenter, prospective observational study.

PLoS One 2014 6;9(10):e109667. Epub 2014 Oct 6.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; China Medical University, Taichung, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186862PMC
December 2015

Clinical characteristics of Q fever and etiology of community-acquired pneumonia in a tropical region of southern Taiwan: a prospective observational study.

PLoS One 2014 17;9(7):e102808. Epub 2014 Jul 17.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan; Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan; School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102556PMC
November 2015

Establishment and Comparison of Two Different Diagnostic Platforms for Detection of DENV1 NS1 Protein.

Int J Mol Sci 2015 Nov 24;16(11):27850-64. Epub 2015 Nov 24.

Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan.

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http://dx.doi.org/10.3390/ijms161126069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661927PMC
November 2015

Empyema thoracis due to Nocardia otitidiscaviarum.

J Microbiol Immunol Infect 2015 Oct 24;48(5):580-1. Epub 2014 Jul 24.

Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jmii.2014.05.004DOI Listing
October 2015

Patients infected with CRF07_BC have significantly lower viral loads than patients with HIV-1 subtype B: mechanism and impact on disease progression.

PLoS One 2014 11;9(12):e114441. Epub 2014 Dec 11.

Center for Infectious Disease and Cancer Research (CICAR), Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Microbiology, Institute of Medical Research and Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263662PMC
October 2015

High prevalence of fluoroquinolone-nonsusceptible Streptococcus pyogenes emm12 in Taiwan.

Diagn Microbiol Infect Dis 2015 Oct 30;83(2):187-92. Epub 2015 Jun 30.

School of Medicine, Sepsis Research Center, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.diagmicrobio.2015.06.018DOI Listing
October 2015

Comparison of serological response to doxycycline versus benzathine penicillin G in the treatment of early syphilis in HIV-infected patients: a multi-center observational study.

PLoS One 2014 13;9(10):e109813. Epub 2014 Oct 13.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; China Medical University, Taichung, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195693PMC
September 2015

Update on infections caused by Stenotrophomonas maltophilia with particular attention to resistance mechanisms and therapeutic options.

Front Microbiol 2015 2;6:893. Epub 2015 Sep 2.

Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine Taipei, Taiwan.

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http://dx.doi.org/10.3389/fmicb.2015.00893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557615PMC
September 2015

Risk factors for microbiologic failure among Taiwanese adults with Mycobacterium abscessus complex pulmonary disease.

J Microbiol Immunol Infect 2015 Aug 22;48(4):437-45. Epub 2014 Oct 22.

Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jmii.2014.08.005DOI Listing
August 2015

The effect of Helicobacter pylori eradication on the levels of essential trace elements.

Biomed Res Int 2014 26;2014:513725. Epub 2014 Jun 26.

Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan ; Department of Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

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http://dx.doi.org/10.1155/2014/513725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274842PMC
August 2015

Development of an Animal Model for Alcoholic Liver Disease in Zebrafish.

Zebrafish 2015 Aug 29;12(4):271-80. Epub 2015 Apr 29.

8 School of Medicine, College of Medicine, Kaohsiung Medical University , Kaohsiung, Taiwan .

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http://dx.doi.org/10.1089/zeb.2014.1054DOI Listing
August 2015

Large Dengue virus type 1 outbreak in Taiwan.

Emerg Microbes Infect 2015 Aug 5;4(8):e46. Epub 2015 Aug 5.

Center for Infectious Disease and Cancer Research, Kaohsiung Medical University , Kaohsiung 80708, Taiwan ; Center for Dengue Fever Control and Research, Kaohsiung Medical University , Kaohsiung 80708, Taiwan ; Department of Microbiology and Immunology, College of Medicine, Kaohsiung Medical University , Kaohsiung 80708, Taiwan.

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http://dx.doi.org/10.1038/emi.2015.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576165PMC
August 2015

The utilization of a new immunochromatographic test in detection of Helicobacter pylori antibody from maternal and umbilical cord serum.

Biomed Res Int 2014 7;2014:568410. Epub 2014 Aug 7.

Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan ; Department of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142160PMC
May 2015

Multicenter study of trimethoprim/sulfamethoxazole-related hepatotoxicity: incidence and associated factors among HIV-infected patients treated for Pneumocystis jirovecii pneumonia.

PLoS One 2014 3;9(9):e106141. Epub 2014 Sep 3.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; China Medical University, Taichung, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153565PMC
May 2015

Optimal dose of benzathine penicillin G for the treatment of early syphilis in HIV-infected patients in the era of combination antiretroviral therapy.

Clin Infect Dis 2015 May 26;60(9):1443-4. Epub 2015 Jan 26.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei Department of Medical Research, China Medical University Hospital China Medical University, Taichung, Taiwan.

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http://dx.doi.org/10.1093/cid/civ029DOI Listing
May 2015

Serological investigation to identify risk factors for post-flood infectious diseases: a longitudinal survey among people displaced by Typhoon Morakot in Taiwan.

BMJ Open 2015 May 14;5(5):e007008. Epub 2015 May 14.

Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Graduate Institute of Medicine, Tropical Medicine Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1136/bmjopen-2014-007008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442151PMC
May 2015

The potential role of nemonoxacin for treatment of common infections.

Expert Opin Pharmacother 2015 Feb 22;16(2):263-70. Epub 2014 Dec 22.

Kaohsiung Medical University, Kaohsiung Medical University Hospital, Division of Infectious Diseases, Department of Internal Medicine , Kaohsiung , Taiwan

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http://dx.doi.org/10.1517/14656566.2015.978288DOI Listing
February 2015

Human spotted fever group rickettsioses are underappreciated in southern Taiwan, particularly for the species closely-related to Rickettsia felis.

PLoS One 2014 22;9(4):e95810. Epub 2014 Apr 22.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan; Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan; School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995941PMC
January 2015

Does long-term use of silver nanoparticles have persistent inhibitory effect on H. pylori based on Mongolian gerbil's model?

Biomed Res Int 2014 17;2014:461034. Epub 2014 Apr 17.

Department of Life Sciences, National Chung Hsing University, 250, Kuo-Kuang Road, Taichung City 402, Taiwan.

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http://dx.doi.org/10.1155/2014/461034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016839PMC
January 2015

Pheophytin a inhibits inflammation via suppression of LPS-induced nitric oxide synthase-2, prostaglandin E2, and interleukin-1β of macrophages.

Int J Mol Sci 2014 Dec 9;15(12):22819-34. Epub 2014 Dec 9.

Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.

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http://www.mdpi.com/1422-0067/15/12/22819
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284740PMC
December 2014

Incidence rates of tuberculosis in chronic hepatitis C infected patients with or without interferon based therapy: a population-based cohort study in Taiwan.

BMC Infect Dis 2014 Dec 19;14:705. Epub 2014 Dec 19.

School of Medicine, Graduate Institute of Medicine, Sepsis Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1186/s12879-014-0705-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307221PMC
December 2014

Carbapenems and piperacillin/tazobactam for the treatment of bacteremia caused by extended-spectrum β-lactamase-producing Proteus mirabilis.

Diagn Microbiol Infect Dis 2014 Nov 26;80(3):222-6. Epub 2014 Jul 26.

Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7, Chung-Shan S. Rd, Taipei 100, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.diagmicrobio.2014.07.006DOI Listing
November 2014

Augmented miR-150 expression associated with depressed SOCS1 expression involved in dengue haemorrhagic fever.

J Infect 2014 Oct 5;69(4):366-74. Epub 2014 Jun 5.

Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2014.05.013DOI Listing
October 2014

The first imported human case of Yersinia pseudotuberculosis serotype O1 septicemia presents with acute appendicitis-like syndrome in Taiwan.

J Formos Med Assoc 2014 Sep 3;113(9):656-9. Epub 2012 Mar 3.

Division of Infectious Diseases, Department of Internal Medicine, E-Da Hospital/I-Shou University, Kaohsiung County, Taiwan, Republic of China; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2011.06.020DOI Listing
September 2014

6-Dehydrogingerdione restrains lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages.

J Agric Food Chem 2014 Sep 9;62(37):9171-9. Epub 2014 Sep 9.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University , Kaohsiung, Taiwan.

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http://pubs.acs.org/doi/10.1021/jf501665v
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September 2014

Acid suppressive agents and risk of Mycobacterium tuberculosis: case-control study.

BMC Gastroenterol 2014 May 13;14:91. Epub 2014 May 13.

Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung City 807, Taiwan.

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http://bmcgastroenterol.biomedcentral.com/articles/10.1186/1
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http://dx.doi.org/10.1186/1471-230X-14-91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030068PMC
May 2014

Evaluation of vancomycin dosing protocols to achieve therapeutic serum concentrations in patients receiving high-flux haemodialysis.

Int J Antimicrob Agents 2014 Apr 27;43(4):384-5. Epub 2014 Jan 27.

Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2014.01.002DOI Listing
April 2014

Nemonoxacin (TG-873870) for treatment of community-acquired pneumonia.

Expert Rev Anti Infect Ther 2014 Apr 3;12(4):401-17. Epub 2014 Mar 3.

Department of Internal Medicine, Kaohsiung Medical University Hospital and Kaohsiung Medical University, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1586/14787210.2014.894881DOI Listing
April 2014

Helicobacter pylori and Systemic Disease.

Gastroenterol Res Pract 2014 19;2014:358494. Epub 2014 Mar 19.

Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

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http://dx.doi.org/10.1155/2014/358494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977557PMC
April 2014

Transcriptional Regulation of the Group IIA Secretory Phospholipase A2 Gene by C/EBP in Rat liver and its Relationship to Hepatic Gluconeogenesis during Sepsis.

Emerg Med (Los Angel) 2013 Aug;3:151

Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 802, Taiwan ; Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri 63104-1004, USA.

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http://dx.doi.org/10.4172/2165-7548.1000151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098070PMC
August 2013