Publications by authors named "Yehuda Tzfati"

28Publications

Telomerase, the recombination machinery and Rap1 play redundant roles in yeast telomere protection.

Curr Genet 2020 Nov 6. Epub 2020 Nov 6.

Department of Genetics, The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Safra Campus, Givat Ram, 91904, Jerusalem, Israel.

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November 2020

An RTEL1 Mutation Links to Infantile-Onset Ulcerative Colitis and Severe Immunodeficiency.

J Clin Immunol 2020 Oct 24;40(7):1010-1019. Epub 2020 Jul 24.

Pediatric Gastroenterology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel.

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October 2020

Full length RTEL1 is required for the elongation of the single-stranded telomeric overhang by telomerase.

Nucleic Acids Res 2020 07;48(13):7239-7251

Department of Genetics, The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel.

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July 2020

Trypanosoma brucei UMSBP2 is a single-stranded telomeric DNA binding protein essential for chromosome end protection.

Nucleic Acids Res 2018 09;46(15):7757-7771

Department of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada and Kuvin Center for the Study of Infectious and Tropical Diseases, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.

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September 2018

Human RTEL1 stabilizes long G-overhangs allowing telomerase-dependent over-extension.

Nucleic Acids Res 2018 05;46(9):4533-4545

Institut Curie, PSL Research University, Sorbonne Universités, CNRS UMR3244 Telomere and cancer lab, 75005 Paris, France.

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May 2018

Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects.

J Exp Med 2016 07 18;213(8):1429-40. Epub 2016 Jul 18.

Pediatric Department A and Immunology Service, Jeffrey Modell Foundation Center, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel The Wohl Institute for Translational Medicine, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel

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July 2016

Unraveling the pathogenesis of Hoyeraal-Hreidarsson syndrome, a complex telomere biology disorder.

Br J Haematol 2015 Aug 4;170(4):457-71. Epub 2015 May 4.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

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August 2015

Pyrimidine motif triple helix in the Kluyveromyces lactis telomerase RNA pseudoknot is essential for function in vivo.

Proc Natl Acad Sci U S A 2013 Jul 17;110(27):10970-5. Epub 2013 Jun 17.

Department of Chemistry and Biochemistry and Molecular Biology Institute, University of California, Los Angeles, CA 90095-1569, USA.

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July 2013

Identification of telomerase RNAs from filamentous fungi reveals conservation with vertebrates and yeasts.

PLoS One 2013 14;8(3):e58661. Epub 2013 Mar 14.

Department of Biology, Lake Forest College, Lake Forest, Illinois, USA.

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October 2013

The Trypanosoma brucei telomerase RNA (TER) homologue binds core proteins of the C/D snoRNA family.

FEBS Lett 2013 May 21;587(9):1399-404. Epub 2013 Mar 21.

The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.

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May 2013

"Poisoning" yeast telomeres distinguishes between redundant telomere capping pathways.

Chromosoma 2012 Dec 6;121(6):613-27. Epub 2012 Oct 6.

Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, 91904 Jerusalem, Israel.

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December 2012

Electron-transfer quenching of nucleic acid-functionalized CdSe/ZnS quantum dots by doxorubicin: a versatile system for the optical detection of DNA, aptamer-substrate complexes and telomerase activity.

Biosens Bioelectron 2011 Aug 18;26(12):4681-9. Epub 2011 May 18.

Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

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August 2011

DNAzyme-like activity of hemin-telomeric G-quadruplexes for the optical analysis of telomerase and its inhibitors.

Chembiochem 2010 Nov;11(17):2362-7

Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

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November 2010

Diminished telomeric 3' overhangs are associated with telomere dysfunction in Hoyeraal-Hreidarsson syndrome.

PLoS One 2009 May 22;4(5):e5666. Epub 2009 May 22.

Department of Genetics, The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Givat Ram, Jerusalem, Israel.

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May 2009

The 5' arm of Kluyveromyces lactis telomerase RNA is critical for telomerase function.

Mol Cell Biol 2008 Mar 14;28(6):1875-82. Epub 2008 Jan 14.

Department of Genetics, The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel.

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March 2008

A critical three-way junction is conserved in budding yeast and vertebrate telomerase RNAs.

Nucleic Acids Res 2007 13;35(18):6280-9. Epub 2007 Sep 13.

Department of Genetics, The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Givat Ram, 91904 Jerusalem, Israel.

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November 2007

Pseudoknot structures with conserved base triples in telomerase RNAs of ciliates.

Nucleic Acids Res 2007 7;35(18):6150-60. Epub 2007 Sep 7.

Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, CA 94158-2517, USA.

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November 2007

Telomerase core components protect Candida telomeres from aberrant overhang accumulation.

Proc Natl Acad Sci U S A 2007 Jul 3;104(28):11682-7. Epub 2007 Jul 3.

Department of Microbiology and Immunology, W. R. Hearst Microbiology Research Center, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.

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July 2007

A triple helix within a pseudoknot is a conserved and essential element of telomerase RNA.

Mol Cell Biol 2007 Mar 8;27(6):2130-43. Epub 2007 Jan 8.

Department of Genetics, The Hebrew University of Jerusalem, Israel.

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March 2007

A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein.

Proc Natl Acad Sci U S A 2004 Oct 15;101(41):14713-8. Epub 2004 Sep 15.

Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA.

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October 2004

A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity.

RNA 2003 Nov;9(11):1323-32

Department of Chemistry and Biochemistry, and Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80309-0215, USA.

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November 2003

A novel pseudoknot element is essential for the action of a yeast telomerase.

Genes Dev 2003 Jul 27;17(14):1779-88. Epub 2003 Jun 27.

Department of Biochemistry and Biophysics, University of California-San Francisco, San Francisco, CA 94143-2200, USA.

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July 2003

A bulged stem tethers Est1p to telomerase RNA in budding yeast.

Genes Dev 2002 Nov;16(21):2800-12

Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309-0215, USA.

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November 2002