Publications by authors named "Ye Jiawen"

11 Publications

  • Page 1 of 1

AMH was independently associated with central obesity but not with general obesity in women with PCOS.

Endocr Connect 2021 Nov 1. Epub 2021 Nov 1.

C Liu, Fujian Medical University, Fuzhou, China.

Objective: Anti-Müllerian hormone (AMH) is recognized as the most important biomarker for ovarian reserve. In this cross-sectional study, we aimed to explore the potential association of AMH with central obesity or general obesity in women with polycystic ovary syndrome (PCOS).

Methods: In this cross-sectional study, 179 patients with PCOS were enrolled and underwent anthropometric measurements (BMI and waist circumference (WC)) and serum AMH level detection. Pearson's correlation and multivariable logistic regression analyses were performed to determine associations of AMH with central obesity and general obesity.

Results: Subjects with the increasing of body mass index (BMI) showed significantly lower values of AMH (median (IQR) 8.95 (6.03-13.60) ng/mL in normal weight group, 6.57 (4.18-8.77) ng/mL in overweight group, and 6.03 (4.34-9.44) ng/mL in obesity group, respectively, p=0.001), but higher levels of systolic blood pressure, fasting insulin, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and obesity indices (WC, hip circumferences, waist-to-hip ratio (WHR), waist-to-height ratio (WHtR) and Chinese visceral adiposity index (CVAI)) respectively. Compared with the group of PCOS women without central obesity, the group with central obesity had significantly lower value of AMH (median (IQR) 8.56(5.29-12.96) vs. 6.22(4.33-8.82) ng/mL; p=0.003). Pearson's correlation analysis showed that AMH were significantly and negatively correlated with BMI (r=-0.280; p<0.001), WC (r=-0.263; p<0.001), WHtR (r=-0.273; p<0.001), and CVAI (r=-0.211; p=0.006) respectively. Multivariate logistic regression analysis with adjustment for potential confounding factors showed that AMH was independently and negatively associated with central obesity, but was not significantly associated with general obesity.

Conclusions: AMH was independently and negatively associated with central obesity. Closely monitoring WC and AMH should be addressed in terms of assessing ovarian reserve in women with PCOS.
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http://dx.doi.org/10.1530/EC-21-0243DOI Listing
November 2021

Incidence and Risk Factors for Adjacent Segment Disease After Transforaminal Lumbar Interbody Fusion in Patients with Lumbar Degenerative Diseases.

Int J Gen Med 2021 15;14:8185-8192. Epub 2021 Nov 15.

Department of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, People's Republic of China.

Purpose: To explore the incidence and risk factors for adjacent segment disease (ASD) in patients with lumbar degenerative diseases after transforaminal lumbar interbody fusion (TLIF).

Patients And Methods: The clinical data of 1258 patients who underwent transforaminal lumbar interbody fusion (TLIF) for lumbar degenerative diseases in our hospital from January 2011 to December 2017 were retrospectively analyzed. Patients were divided into the ASD group and non-ASD (N-ASD) group, and the incidence of ASD was calculated. We compared age, BMI, comorbidities, surgery-related parameters, and imaging parameters before surgery between the two groups and used univariate analysis and logistic regression analysis to explore the risk factors for ASD.

Results: Among the 1258 patients who underwent TLIF due to lumbar degenerative diseases, 65 patients developed ASD and received surgical treatment for it, for an incidence of 5.2%. The average onset time of ASD was 68.3±25.1 (20-123) months. Univariate analysis showed that BMI, hypertension, preoperative adjacent segment disc degeneration and preoperative adjacent intervertebral disc height were significantly different between the ASD and N-ASD groups (P< 0.05). Incorporating the above indicators into the logistic regression model, the results showed that BMI and preoperative adjacent intervertebral disc degeneration were risk factors for ASD after TLIF.

Conclusion: The incidence of ASD after TLIF in patients with lumbar degenerative disease is approximately 5.2%. High BMI and preoperative adjacent segment disc degeneration are risk factors for ASD after TLIF.
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http://dx.doi.org/10.2147/IJGM.S337298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604649PMC
November 2021

Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults.

BMC Gastroenterol 2021 Nov 18;21(1):431. Epub 2021 Nov 18.

Epidemiology Research Unit, Translational Medical Research Center, The First Affiliated Hospital, Xiamen University, Xiamen, China.

Purpose: The aim of the study is to explore the independent association of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) with hepatic steatosis and insulin resistance.

Methods: A cross-sectional study of 88 overweight/obese adults who underwent anthropometric measurements [BMI, waist circumference (WC) and waist-to-height ratio (WHtR)], hepatic steatosis assessment (FibroScan) and thyroid-related hormones tests was conducted from 2018 to 2020 in Xiamen, China.

Results: Subjects with increasing tertiles of FT3 showed significantly higher levels of controlled attenuation parameter (CAP) ((295.4 ± 44.1, 290.1 ± 68.2 and 331.7 ± 43.6 (dB/m) for tertile 1-3, respectively, p = 0.007) and fatty liver index (FLI) score (47.7 (33.9-60.8), 61.5 (45.1-88.9) and 90.5 (84.5-94.8), respectively, p < 0.001). FT3 significantly and positively correlated with obesity index (BMI, WC, and WHtR), homeostatic model assessment of insulin resistance (HOMA-IR) and hepatic steatosis (CAP and FLI). Multivariable linear regression analyses with adjustment for potential confounding factors showed FT3 was independently associated with BMI (regression coefficient (β (95%CI): 0.024 (0.004-0.043), p = 0.020), HOMA-IR (β (95%CI): 0.091 (0.007-0.174), p = 0.034), CAP (β (95%CI): 25.45 (2.59-48.31), p = 0.030) and FLI (β (95%CI): 0.121 (0.049-0.194), p = 0.001). Neither FT4 nor TSH was significantly associated with any indicators of obesity, insulin resistance or hepatic steatosis.

Conclusions: Increased FT3, but not FT4 or TSH, was independently associated with higher risks of hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults. Trial registration Registration is not applicable for our study.
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http://dx.doi.org/10.1186/s12876-021-02011-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8603528PMC
November 2021

Age Differences in Visual Attention and Responses to Intergenerational and Non-intergenerational Workplace Conflicts.

Front Psychol 2021 7;12:604717. Epub 2021 Jun 7.

Psychology Laboratories, Department of Social and Behavioural Sciences, City University of Hong Kong, Kowloon, Hong Kong.

Intergenerational conflict occurs commonly in the workplace because of age-related differences in work attitudes and values. This study aimed to advance the current literature on aging and work by examining whether younger and older workers differ in their visual attention, emotional responses, and conflict strategies when observing hypothetical conflict vignettes involving a coworker from a similar or dissimilar age group. The indirect effect of age group on emotional responses and conflict strategies through visual fixation on conflict scenes was also examined. Utilizing eye tracking, the visual attention of younger and older workers while watching two hypothetical workplace task conflict videos was recorded and compared. The participants were also asked to imagine how they would respond if they were the main actor in the vignettes. A total of 94 working adults, including 48 younger workers and 46 older workers, participated in the eye tracking experiment. Older workers reported fewer negative and more positive emotions than their younger counterparts after watching the conflict videos, particularly those on the non-intergenerational conflict. Younger workers used more dominating in the intergenerational conflict than in the non-intergenerational conflict; such discrepancy between conflict types was relatively small in older workers. Compared with younger workers, older workers fixated significantly less on the coworker during the intergenerational conflict scenes. A significant indirect effect of age group through visual fixation on the coworker was observed for positive emotions and avoiding. Results revealed that older workers may regulate their emotional reactions and conflict strategies to workplace conflicts by reducing their attention to negative stimuli.
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http://dx.doi.org/10.3389/fpsyg.2021.604717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215446PMC
June 2021

5,7,3',4'-flavan-on-ol (taxifolin) protects against acetaminophen-induced liver injury by regulating the glutathione pathway.

Life Sci 2019 Nov 5;236:116939. Epub 2019 Oct 5.

Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address:

Taxifolin (TAX) reportedly exerts protective and therapeutic effects in liver. Herein, the effects of TAX against acetaminophen (APAP)-induced hepatotoxicity were investigated. Pharmacodynamics, pharmacology and metabolomics analyses of TAX were assessed on C57 mice and L-02 cells. TAX was administered for 7 days, and APAP was given on the last day to establish an acute liver injury model. ALT and AST levels were determined, and liver ROS, MDA, GST, GSH and GPX1 were analysed. The expression and protein abundance of GPX1, GPS-Pi, GCLC and GCLM were assessed by PCR and western blotting, and metabolic changes in cells and serum were investigated by UPLC-Q-Orbitrap-MS. Serum ALT and AST, and liver ROS, MDA, GST, GSH and GPX1 levels confirmed the protective effects of TAX. Besides, we found Only treating with TAX decreased the expression of CYP2E1 in mice liver tissue. TAX reversed the APAP-induced decrease in cell viability in L-02 cells, and reduced cellular ROS levels. Furthermore, TAX reversed the APAP-induced decrease in antioxidant enzymes at both mRNA and protein levels. Metabolomics analysis identified metabolites mainly related to glutathione metabolism (36 in vivo and 23 in vitro). The concentration of glutathione, oxidized glutathione, carnitine, succinic acid, pyroglutamic acid, citrulline, taurine, palmitoleic acid, phytoshingosine-1-P and sphingosine-1-P were close to normal levels after treating with TAX. These results indicate that TAX prevents APAP-induced liver injury by inhibiting APAP metabolic activation mediated by CYP450 enzymes, modulating glutathione metabolism, and expression of related antioxidative signals. These properties could be harnessed to prevent or treat hepatotoxicity.
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http://dx.doi.org/10.1016/j.lfs.2019.116939DOI Listing
November 2019

Expression and clinical significance of doublecortin (DCX) in pituitary adenoma.

Bull Cancer 2019 Dec 31;106(12):1080-1085. Epub 2019 Jul 31.

Neurosurgery Department, Dongguan people's hospital of Guangdong province, 523000 Dongguan, Guangdong, China.

Purpose: To date, no studies have investigated the expression of Doublecortin (DCX) in pituitary adenomas or evaluated the clinical value of DCX in the diagnosis of pituitary adenomas. This study aims to determine the expression levels of DCX in pituitary adenomas and to investigate its role in the staging of this condition.

Methods: Forty-six patients with pituitary adenomas were recruited. The expression of DCX in tumor sections from pituitary adenomas was determined using immunohistochemistry and quantitative real-time polymerase chain reaction. Tumors were classified as either invasive or non-invasive on the basis of clinical stage and using the Knosp grading system. Differences in the expression of DCX and its association with clinical characteristics were investigated. The potential of the measurement of DCX levels for distinguishing between invasive and non-invasive tumors was estimated using receiver operating characteristic (ROC) analysis.

Results: Expression of DCX were correlated with Knosp grade. No significant association was observed between DCX level and the clinical stage of the tumors. The expression of DCX was higher in tumors with Knosp 3 and lowest in Knosp 1, at both the mRNA and protein levels. Using DCX as a biomarker for the prediction of tumor invasiveness in pituitary adenoma patients, the area under the ROC curve was 0.829 (95% confidence interval, 0.6-28.1), which is higher than that obtained using Knosp grade.

Conclusions: The expression of DCX is related to the Knosp grade of pituitary adenoma. DCX levels can be used as a biomarker for tumor invasiveness prediction in pituitary adenoma patients.
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http://dx.doi.org/10.1016/j.bulcan.2019.05.009DOI Listing
December 2019

Adaptation and validation of Richmond Compulsive Buying Scale in Chinese population.

J Behav Addict 2018 Sep 28;7(3):760-769. Epub 2018 Sep 28.

3 Department of Applied Psychology, Lingnan University , New Territories, Hong Kong SAR.

Background And Aims: Compulsive buying (CB) is a behavioral addiction that is conceptualized as an obsessive-compulsive and impulsive-control disorder. The Richmond Compulsive Buying Scale (RCBS), a six-item self-reporting instrument that has been validated worldwide, was developed based on this theoretical background. This study aimed to adapt RCBS to the Chinese population (RCBS-TC) to guide future national and international prevalence studies.

Methods: This methodological study was conducted in two phases. Phase 1 involved the forward and backward translation of RCBS, the content and face validation of the RCBS, and the evaluation of its translation adequacy. Phase 2 involved the psychometric testing of RCBS-TC for its internal consistency, stability, and construct validity using confirmatory factor analysis (CFA).

Results: In Phase 1, RCBS-TC obtained satisfactory item-level (I-CVI = 83.3%-100%) and scale-level content validity index (CVI/AVE = 97.2%), comprehensibility (100%), and translation adequacy [intraclass correlation coefficient (ICC) = 0.858]. In Phase 2, based on data collected from 821 adults, RCBS-TC demonstrated a satisfactory internal consistency (Cronbach's α = .88; corrected item-total correlation coefficients = 0.61-0.78) 2-week test-retest reliability (ICC = 0.82 based on 61 university students). For construct validation, the CFA results indicated that the corrected first-order two-factor models were acceptable with the same goodness-of-fit indices (χ/df = 8.56, CFI = 0.99, NFI = 0.98, IFI = 0.99, and RMSEA = 0.09). The 2-week test-retest reliability of RCBS-TC (n = 61) was also satisfactory (ICC = 0.82).

Discussion And Conclusions: This methodological study adopted appropriate and stringent procedures to ensure that the translation and validation of RCBS-TC was of quality. The results indicate that this scale has a satisfactory reliability and validity for the Chinese population.
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http://dx.doi.org/10.1556/2006.7.2018.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426376PMC
September 2018

Remote magnetic navigation facilitates the ablations of frequent ventricular premature complexes originating from the outflow tract and the valve annulus as compared to manual control navigation.

Int J Cardiol 2018 Sep;267:94-99

Department of Cardiology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Objective: The purpose of this study was to assess the role of remote magnetic navigation (RMN) in the ablation of ventricular premature complexes (VPCs) arising from outflow tracts (OT) and valve annuli by comparing to manual control navigation (MCN).

Methods: A total of 152 patients with frequent VPCs were prospectively enrolled. 64 (42%) patients underwent ablation guided by RMN. Acute success rate was defined as the complete elimination and non-inducibility of clinical VPCs during the procedure.

Results: Overall, acute success rate of RMN group was not different from MCN group (87.5% vs 84.1%, p = 0.56). Compared to MCN group, the fluoroscopic time of OT-VPCs ablation in the RMN group was significantly reduced by 67% (2.9 ± 2.3 min vs 8.9 ± 9.7 min, p = 0.006), and the ablation applications in successful cases were significantly reduced (11 ± 7 vs 15 ± 11, p = 0.018). Compared to MCN, RMN significantly decreased ablation applications (15 ± 9 vs 23 ± 9, p = 0.013) in the acute success rates of ablating VPCs of valve annulus, and has a trend of a higher success rate for VPCs arising from tricuspid annulus (10/11 vs 7/12, p = 0.193). No complications occurred in the RMN group. Three cases of cardiac tamponade and one case of transient atrioventricular block occurred in the MCN group (p = 0.22). After a mean follow up of 16.2 months, 2/56 and 3/74 patients had a recurrence of VPCs in the RMN group and MCN group respectively (p = 0.75).

Conclusions: When compared to MCN, RMN-guided ablation for VPCs was just as effective and safe, with the added benefit of reduced fluoroscopic time and fewer ablation applications.
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http://dx.doi.org/10.1016/j.ijcard.2018.03.105DOI Listing
September 2018

Sequential mediating effects of provided and received social support on trait emotional intelligence and subjective happiness: A longitudinal examination in Hong Kong Chinese university students.

Int J Psychol 2019 Aug 3;54(4):478-486. Epub 2018 Apr 3.

Department of Applied Social Sciences, City University of Hong Kong, Hong Kong.

Past research has often focused on the effects of emotional intelligence and received social support on subjective well-being yet paid limited attention to the effects of provided social support. This study adopted a longitudinal design to examine the sequential mediating effects of provided and received social support on the relationship between trait emotional intelligence and subjective happiness. A total of 214 Hong Kong Chinese undergraduates were asked to complete two assessments with a 6-month interval in between. The results of the sequential mediation analysis indicated that the trait emotional intelligence measured in Time 1 indirectly influenced the level of subjective happiness in Time 2 through a sequential pathway of social support provided for others in Time 1 and social support received from others in Time 2. These findings highlight the importance of trait emotional intelligence and the reciprocal exchanges of social support in the subjective well-being of university students.
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http://dx.doi.org/10.1002/ijop.12484DOI Listing
August 2019

An intermediary enhances out-group trust and in-group profit expectation of Chinese but not Australians.

Int J Psychol 2017 Jun 27;52(3):189-196. Epub 2015 Jul 27.

Department of Psychology, Remin University of China, Beijing, China.

In this research, we made a theoretical distinction between direct and intermediary-mediated trust situations, and conducted a cross-cultural (Chinese vs. Australians) investment trust game to test the overlooked effects of an intermediary on investors' trust decisions, with respect to how much to invest in and expect from trustees. Compared to situations of direct trust, a nominal intermediary increased the number of Chinese investors expecting in-group trustees to repay a profit on their investments (Hypothesis 1) and raised their level of investment in out-group trustees (Hypothesis 2). These results applied to Chinese, but not Australians in support of the proposal that a nominal intermediary would serve as a cue to activate different cultural stereotypes of the functions and meanings of an intermediary with respect to trust and expectation of reciprocity. Coexisting with these culture-specific effects of an intermediary, the minimal categorisation of people into in-group and out-group on trivial grounds leads to a highly significant in-group favouritism in investment levels of both Chinese and Australians (Hypothesis 3).
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http://dx.doi.org/10.1002/ijop.12199DOI Listing
June 2017

A psychometric study of the Test of Everyday Attention for Children in the Chinese setting.

Arch Clin Neuropsychol 2008 Jul 8;23(4):455-66. Epub 2008 May 8.

Neuropsychology and Applied Cognitive Neuroscience Laboratory, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.

Objective: To explore the psychometric properties of the Test of Everyday Attention for Children (TEA-Ch) in the context of a Chinese setting.

Methods: Confirmatory factor analysis was conducted to examine the construct validity of the Chinese version of the TEA-Ch among a group of 232 children without attention deficit hyperactivity disorder (ADHD). Test-retest reliability was tested on a random sub-sample of 20 children at a 4-week interval. Clinical discrimination was also examined by comparing children with and without ADHD (22 in each group) on the performances of the TEA-Ch.

Results: The current Chinese sample demonstrated a three-factor solution for attentional performance among children without ADHD, namely selective attention, executive control/switch, and sustained attention (chi(2)(24)=34.56; RMSEA=.044; p=.075). Moreover, the whole test demonstrated acceptable test-retest reliability at a 4-week interval among a small sub-sample. Children with ADHD performed significantly more poorly than healthy controls in most of the subtests of the TEA-Ch.

Conclusions: The results of the present study demonstrate that the test items remain useful in China, a culture very different from that in which the test originated. Finally, the TEA-Ch also presents several advantages when compared to other conventional objective measures of attention.
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http://dx.doi.org/10.1016/j.acn.2008.03.007DOI Listing
July 2008
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