Publications by authors named "Ye Han"

288 Publications

Recommending encounters according to the sociodemographic characteristics of patient strata can reduce risks from type 2 diabetes.

PLoS One 2021 12;16(4):e0249084. Epub 2021 Apr 12.

Christie Clinic, Champaign, Illinois, United States of America.

Objectives: Physician encounters with patients with type 2 diabetes act as motivation for self-management and lifestyle adjustments that are indispensable for diabetes treatment. We elucidate the sociodemographic sources of variation in encounter usage and the impact of encounter usage on glucose control, which can be used to recommend encounter usage for different sociodemographic strata of patients to reduce risks from Type 2 diabetes.

Data And Methods: We analyzed data from a multi-facility clinic in the Midwestern United States on 2124 patients with type 2 diabetes, from 95 ZIP codes. A zero-inflated Poisson model was used to estimate the effects of various ZIP-code level sociodemographic variables on the encounter usage. A multinomial logistic regression model was built to estimate the effects of physical and telephonic encounters on patients' glucose level transitions. Results from the two models were combined in marginal effect analyses.

Results And Conclusions: Conditional on patients' clinical status, demographics, and insurance status, significant inequality in patient encounters exists across ZIP codes with varying sociodemographic characteristics. One additional physical encounter in a six-month period marginally increases the probability of transition from a diabetic state to a pre-diabetic state by 4.3% and from pre-diabetic to the non-diabetic state by 3.2%. Combined marginal effect analyses illustrate that a ZIP code in the lower quartile of high school graduate percentage among all ZIP codes has 1 fewer physical encounter per six months marginally compared to a ZIP code at the upper quartile, which gives 5.4% average increase in the probability of transitioning from pre-diabetic to diabetic. Our results suggest that policymakers can target particular patient groups who may have inadequate encounters to engage in diabetes care, based on their immediate environmental sociodemographic characteristics, and design programs to increase their encounters to achieve better care outcomes.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0249084PLOS
April 2021

Biomechanics of artificial pedicle fixation in a 3D-printed prosthesis after total en bloc spondylectomy: a finite element analysis.

J Orthop Surg Res 2021 Mar 24;16(1):213. Epub 2021 Mar 24.

Department of Orthopaedics, Tianjin Hospital, Tianjin, China.

Background: This study compared the biomechanics of artificial pedicle fixation in spine reconstruction with a 3-dimensional (3D)-printed prosthesis after total en bloc spondylectomy (TES) by finite element analysis.

Methods: A thoracolumbar (T10-L2) finite element model was developed and validated. Two models of T12 TES were established in combination with different fixation methods: Model A consisted of long-segment posterior fixation (T10/11, L1/2) + 3D-printed prosthesis; and Model B consisted of Model A + two artificial pedicle fixation screws. The models were evaluated with an applied of 7.5 N·m and axial force of 200 N. We recorded and analyzed the following: (1) stiffness of the two fixation systems, (2) hardware stress in the two fixation systems, and (3) stress on the endplate adjacent to the 3D-printed prosthesis.

Results: The fixation strength of Model B was enhanced by the screws in the artificial pedicle, which was mainly manifested as an improvement in rotational stability. The stress transmission of the artificial pedicle fixation screws reduced the stress on the posterior rods and endplate adjacent to the 3D-printed prosthesis in all directions of motion, especially in rotation.

Conclusions: After TES, the posterior long-segment fixation combined with the anterior 3D printed prosthesis could maintain postoperative spinal stability, but adding artificial pedicle fixation increased the stability of the fixation system and reduced the risk of prosthesis subsidence and instrumentation failure.
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http://dx.doi.org/10.1186/s13018-021-02354-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988983PMC
March 2021

Neonatal hereditary spherocytosis caused by a de novo frameshift mutation of the SPTB gene characterized by hydrops fetalis: A case report.

Medicine (Baltimore) 2021 Mar;100(12):e24804

Department of Pediatrics, Peking University People's Hospital, Beijing, China.

Rationale: The etiology of non-immune hydrops fetalis is complex, and its prognosis is poor. One of its main causes is anemia. There are few reports on hydrops fetalis due to anemia caused by hereditary spherocytosis (HS), especially regarding its occurrence in the neonatal period. Thus, we report on a case of neonatal HS caused by a new SPTB gene mutation that was characterized by hydrops fetalis.

Patient Concerns: A neonate with intrauterine hydrops fetalis showed severe hyperbilirubinemia and anemia, reticulocytosis, and hepatosplenomegaly. Laboratory examination findings were normal.

Diagnoses: Gene sequencing of the patient and his parents showed a de novo frameshift mutation in the patient's SPTB gene. Ultimately, the patient was diagnosed with HS.

Interventions: Exchange and red blood cell transfusions were performed in the neonatal period.

Outcomes: The child was discharged from the hospital 14 days postnatal because his hemoglobin and bilirubin levels were stable. Red blood cell transfusion was performed once in infancy; however, no further red blood cell transfusions were required within 2 years of age.

Lessons: Hydrops fetalis can be a manifestation of HS. Genetic detection can help confirm the diagnosis of suspected neonatal HS undocumented by other laboratory examinations.
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http://dx.doi.org/10.1097/MD.0000000000024804DOI Listing
March 2021

Photocatalytic mechanism and performance of a novel wool flake-BiFeO3 nanosheet-TiO2 (wool-BFO-TiO2) core-shell structured composite photocatalyst.

Nanotechnology 2021 Mar 19. Epub 2021 Mar 19.

University of Leeds School of Design, Leeds, West Yorkshire, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

In this study, BiFeO3 (BFO) nanosheets ground from BFO particles were first incorporated with wool pallets to construct the sandwich-like wool-BFO composites using the vibration-assisted ball milling technique in freezing condition. The wool-BFO composites were then loaded with a thick layer of TiO2 nanoparticles to prepare the core-shell structured wool-BFO-TiO2 composites using the hydrothermal synthesis process. The microstructure of the core-shell wool-BFO-TiO2 composites and its photocatalytic applications were systematically examined by using a series of characterization methods. The trapping experiments and electron spin resonance (ESR) spectra were also employed to judge the active radical species like superoxide radical (O2-), singlet oxygen (1O2), hole (h+), and hydroxyl radical (OH) by using benzoquinone (BQ), furfuryl alcohol (FFA), ethylenediamine tetraacetic acid (EDTA), and tert-butanol (TBA) as the scavengers, respectively. The photodegradation performance of the wool-BFO-TiO2 composites was measured using more resistant methyl orange (MO) dye as the pollutant model. In comparison with the wool-TiO2 or wool-BFO composites, the superior photocatalytic properties of the wool-BFO-TiO2 composites under visible light irradiation were attributed to the presence of mesopores and macropores, the large specific surface area, and the intimate interface between wool-BFO composites and TiO2 nanoparticles, the coexistence of Fe3+, Fe2+, Bi3+, Bi(3-x)+, Ti4+, and Ti3+species, and the strong visible light harvesting, thus leading to the fast separation of photo-generated electrons and holes pairs. The wool-BFO-TiO2 composites could be used for the repeatedly photodegradation of organic pollutants, while be recycled easily by using a magnet. The active radical species of the wool-BFO-TiO2 composites were O2- and 1O2 rather than OH and h+, which were involved in the photodegradation of MO dye under visible light irradiation.
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http://dx.doi.org/10.1088/1361-6528/abf072DOI Listing
March 2021

Intestinal Anti-Inflammatory Effects of Selenized Polysaccharides in a Dextran Sulfate Sodium-Induced Inflammatory Bowel Disease Model.

J Med Food 2021 Mar;24(3):236-247

College of Food Science and Engineering, Ocean University of China, Qingdao, China.

The purpose of this study was to examine the alleviative effects of selenized polysaccharides from (ulvan-Se) on inflammatory bowel disease (IBD) in mice. The dextran sulfate sodium (DSS)-induced IBD mouse model was used to explore the protective effects of ulvan-Se on the intestinal mechanical and immune barrier. At doses less than 1208 mg/kg·bw ulvan-Se showed no significant damage to Institute of Cancer Research (ICR) mice in an acute toxicity test. The results showed that DSS destroyed the mechanical barrier, which includes epithelial cells, while ulvan-Se promoted mRNA expression of tight junction proteins (zonula occludens protein 1, occludin, and claudin-1) and inhibited the infiltration of white blood cells into the intestines. At 100 mg/kg·bw, ulvan-Se enhanced the antioxidant capacity of mice more effectively than the 50 mg/kg·bw ulvan-Se. Furthermore, ulvan-Se improved the intestinal immune barrier by increasing immunoglobulin A and immunoglobulin M, while regulating the levels of interleukin (IL)-1, interferon-, and IL-4. Oral administration of ulvan-Se also suppressed tumor necrosis factor-, IL-1, IL-6, and cyclooxygenase-2 mRNA expression mediated by the nuclear factor kappa B pathway. Taken together, our findings reveal that ulvan-Se could be used as a potential alternative supplement for reducing intestinal inflammation in IBD.
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http://dx.doi.org/10.1089/jmf.2020.4787DOI Listing
March 2021

Kinematic Characteristics and Biomechanical Changes of Lower Lumbar Facet Joints Under Different Loads.

Orthop Surg 2021 Mar 11. Epub 2021 Mar 11.

Department of Spine Surgery, Tianjin Hospital, Tianjin, China.

Objective: To explore the kinematic biomechanical changes and symmetry in the left and right sides of the facet joints of lumbar spine segments under different functional loads.

Methods: Participants (n = 10) performing standing flexion and extension movements were scanned using computed tomography (CT) and dual fluoroscopy imagine system. Instantaneous images of the L -S vertebrae were captured, and by matching a three-dimensional CT model with contours from dual fluoroscopy images, in vivo facet joint movements were reproduced and analyzed. Translations and rotations of lumbar vertebral (L and L ) facet joints of data were compared for different loads (0, 5, 10 kg). The participants performed flexion and extension movements in different weight-bearing states, the translations and angles changes were calculated respectively.

Results: From standing to extension, there were no statistical differences in rotation angles for the facet joint processes of different vertebral segment levels under different weight loads (P > 0.05). Mediolateral axis and cranio-caudal translations under different weight loads were not statistically different for vertebral segment levels (P > 0.05). Anteroposterior translations for L (1.4 ± 0.1 mm) were greater than those for L (1.0 ± 0.1 mm) under the different load conditions (P = 0.04). Bilaterally, mediolateral, anteroposterior, and cranio-caudal translations of the facet joints under different weights (0, 10 kg) for each segment level (L and L ) were symmetric (P > 0.05). From flexion to standing, there were no statistical differences in rotation angles for different weights (0, 5, 10 kg) for each level (L and L ) (P > 0.05). There were no statistical differences between mediolateral, anteroposterior, and cranio-caudal translations at each segment level (L and L ) under different loads (P > 0.05). Under the condition of no weight (0 kg), L mediolateral translations on the left side (1.7 ± 1.6 mm) were significantly greater (P = 0.03) than those on the right side (1.6 ± 1.6 mm). Left side (1.0 ± 0.7 mm) L mediolateral translations were significantly smaller (P = 0.03) than those on the right side (1.1 ± 0.7 mm). There were no statistical differences between different weights for either anteroposterior and cranio-caudal translations (P > 0.05). There were no statistical differences for mediolateral, anteroposterior, and cranio-caudal translations for 10 kg (P > 0.05).

Conclusion: Lumbar spine facet joint kinematics did not change significantly with increased loads. Anteroposterior translations for L were greater than those for L of the vertebral segments are related to the coronal facet joint surface. Changes in facet surface symmetry indicates that the biomechanical pattern between facet joints may change.
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http://dx.doi.org/10.1111/os.12894DOI Listing
March 2021

Pro-inflammatory cytokine interleukin-6-induced hepcidin, a key mediator of periodontitis-related anemia of inflammation.

J Periodontal Res 2021 Mar 3. Epub 2021 Mar 3.

Department of Periodontology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, China.

Objectives: To investigate whether anemia of inflammation (AI) occurs in periodontitis patients and to further explore underlying pathogenesis of periodontitis-related AI by an experimental periodontitis model.

Background: Previous studies have reported periodontitis patients could show a tendency toward AI. However, the relationship between periodontitis and AI remains unclear, and the related pathological mechanisms have not been identified.

Materials And Methods: Periodontal clinical parameters, inflammatory markers, and anemia-related indicators were compared between 98 aggressive periodontitis (AgP) patients and 103 healthy subjects. An experimental periodontitis model was induced by ligature placement in mice. The changes in mice inflammatory markers, anemia indicators, hepcidin mRNA expression, and serum hepcidin concentrations were measured. Human and mouse liver cells were treated with interleukin-6 (IL-6) for analyzing the changes in hepcidin expression based on mRNA and protein levels.

Results: AgP patients exhibited higher white blood cell counts, IL-6, and C-reactive protein. Adjusted linear regression analyses showed correlations between AgP and decreased hemoglobin (HGB) and hematocrit (HCT). The ligature-induced periodontitis caused systemic inflammation and elevated IL-6 levels. Lower red blood cell counts, HGB, and HCT were detected, whereas the levels of hepcidin mRNA expression and serum hepcidin concentrations increased. The treatment of hepatocytes with IL-6 induced both hepcidin mRNA expression and hepcidin secretion.

Conclusions: Systemic inflammation induced by periodontitis leads to an increased risk for AI. IL-6-induced hepcidin could play a central mediator role and act as a key pathologic mechanism. Our results demonstrate periodontitis may be considered as an additional inflammatory disease contributing to the development of AI.
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http://dx.doi.org/10.1111/jre.12865DOI Listing
March 2021

A look-ahead Monte Carlo simulation method for improving parental selection in trait introgression.

Sci Rep 2021 Feb 16;11(1):3918. Epub 2021 Feb 16.

Industrial and Manufacturing Systems Engineering, Iowa State University, Ames, IA, 50011, USA.

Multiple trait introgression is the process by which multiple desirable traits are converted from a donor to a recipient cultivar through backcrossing and selfing. The goal of this procedure is to recover all the attributes of the recipient cultivar, with the addition of the specified desirable traits. A crucial step in this process is the selection of parents to form new crosses. In this study, we propose a new selection approach that estimates the genetic distribution of the progeny of backcrosses after multiple generations using information of recombination events. Our objective is to select the most promising individuals for further backcrossing or selfing. To demonstrate the effectiveness of the proposed method, a case study has been conducted using maize data where our method is compared with state-of-the-art approaches. Simulation results suggest that the proposed method, look-ahead Monte Carlo, achieves higher probability of success than existing approaches. Our proposed selection method can assist breeders to efficiently design trait introgression projects.
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http://dx.doi.org/10.1038/s41598-021-83634-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887201PMC
February 2021

Driving the Interfacial Ion-Transfer Kinetics by Mesoporous TiO Spheres for High-Performance Aqueous Zn-Ion Batteries.

ACS Appl Mater Interfaces 2021 Feb 9;13(7):8181-8190. Epub 2021 Feb 9.

School of Metallurgy and Environment, Central South University, Changsha 410083, China.

The aqueous zinc-ion batteries (ZIBs) have been considered as a promising energy storage device. However, the ion transfer at the Zn metal anode-electrolyte interface is limited by the sluggish kinetics resulting in high interface resistance. Herein, mesoporous TiO (m-TiO) is coated on the Zn foil (Zn-TiO) driving the ion's faster transfer to reduce interface resistance (70.1 Ω vs 799.3 Ω of bare Zn). The lower interface resistance is ascribed to shortening the ion transfer path provided by the mesoporous structure and the smaller Zn absorption energy barrier of the surface of the Zn-TiO anode as well as the unobstructed ion transfer path at the crystal planes (100) of TiO, which have been supported by the density functional theory (DFT) calculation and experiments. Therefore, the Zn-TiO anodes in the symmetrical cells display a low voltage hysteresis (36.5 mV) and long-term cycling stability (500 h at 4.4 mA cm). Especially, the Zn-TiO/MnO full cells show superior cycling performance with a high capacity of 269.8 mAh g after 50 cycles at 0.2 A g and 210.9 mAh g after 1000 cycles at 0.5 A g. The analysis of ion-transfer kinetics at the interface provides deep enlightenment and reference for the study of the metal anodes.
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http://dx.doi.org/10.1021/acsami.0c18433DOI Listing
February 2021

Interfacial Oxidized Gate Insulators for Low-Power Oxide Thin-Film Transistors.

ACS Omega 2021 Feb 15;6(4):2717-2726. Epub 2021 Jan 15.

School of Electronics and Display Engineering, Hoseo University, Asan, Chungnam 31499, Korea.

Low power consumption is essential for wearable and internet-of-things applications. An effective way of reducing power consumption is to reduce the operation voltage using a very thin and high-dielectric gate insulator. In an oxide thin-film transistor (TFT), the channel layer is an oxide material in which oxygen reacts with metal to form a thin insulator layer. The interfacial oxidation between the gate metal and In-Ga-Zn oxide (IGZO) was investigated with Al, Ti, and Mo. Positive bias was applied to the gate metal for enhanced oxygen diffusion since the migration of oxygen is an important factor in interfacial oxidation. Through interfacial oxidation, a top-gate oxide TFT was developed with low source-drain voltages below 0.5 V and a gate voltage swing less than 1 V, which provide low power consumption.
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http://dx.doi.org/10.1021/acsomega.0c04924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7860086PMC
February 2021

Metagenomic insights into Chinese northeast suancai: Predominance and diversity of genes associated with nitrogen metabolism in traditional household suancai fermentation.

Food Res Int 2021 Jan 28;139:109924. Epub 2020 Nov 28.

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, PR China. Electronic address:

Chinese northeast suancai represents a typical and valuable food product that has been handed down by traditional household procedures over centuries. Nitrite is formed and accumulated during the suancai fermentation process and commonly causes food safety problems. The biogeochemical cycle of nitrite may provide a reference and guidance for the enzymatic degradation of nitrite in fermented food. The potential nitrogen metabolic pathways in the microbially driven suancai fermentation were reasonably inferred through monitoring nitrogen conversions and detecting the genes of different functional enzymes. Complex microbial metabolism is responsible for the unique nitrogen conversions during suancai fermentation. The metagenomic results showed that Pseudomonas with nitrate reductase genes (narG, narH, narI) and nitrite reductase genes (nirB, nirD) contributed the most to both nitrite reduction and nitrate reduction. The majority of the sequences of nitrate reductase and nitrite reductase were derived from the families of Pseudomonadaceae, Erwiniaceae and Yersiniaceae. According to the physicochemical analysis, the nitrite concentration of the fermentation broth reached the peak value (0.48 mM) and gradually decreased to the minimum (0.02 mM). The downward trend of the pH and nitrite concentration were closely associated with the nitrite enzymatic degradation period before the acid degradation period. Our results indicated that nitrite removal in suancai fermentation involved the reduction of nitrite to ammonia and denitrification, which were mainly contributed by the reduction of nitrite to ammonia mediated by the nirB/nirD enzyme (Indentified ECs: 1.7.1.15). This research offers new insights into the metagenome-based bioinformatic roles of the previously unstudied microorganisms in spontaneous suancai fermentation for the enzymatic degradation of nitrite. It provides helpful basis for the detection and even elimination of nitrite in suancai and for improving the safety level of suancai.
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http://dx.doi.org/10.1016/j.foodres.2020.109924DOI Listing
January 2021

Biomechanical finite element analysis of vertebral column resection and posterior unilateral vertebral resection and reconstruction osteotomy.

J Orthop Surg Res 2021 Jan 28;16(1):88. Epub 2021 Jan 28.

Department of Orthopaedics, Tianjin Hospital, No. 406, Jiefang South Road, Hexi District, Tianjin, China.

Background: Regarding the repair of vertebral compression fractures, there is a lack of adequate biomechanical verification as to whether only half of the vertebral body and the upper and lower intervertebral discs affect spinal biomechanics; there also remains debate as to the appropriate length of fixation.

Methods: A model of old vertebral compression fractures with kyphosis was established based on CT data. Vertebral column resection (VCR) and posterior unilateral vertebral resection and reconstruction (PUVCR) were performed at T12; long- and short-segment fixation methods were applied, and we analyzed biomechanical changes after surgery.

Results: Range of motion (ROM) decreased in all fixed models, with lumbar VCR decreasing the most and short posterior unilateral vertebral resection and reconstruction (SPUVCR) decreasing the least; in the long posterior unilateral vertebral resection and reconstruction (LPUVCR) model, the internal fixation system produced the maximum VMS stress of 213.25 mPa in a lateral bending motion and minimum stress of 40.22 mPa in a lateral bending motion in the SVCR.

Conclusion: There was little difference in thoracolumbar ROM between PUVCR and VCR models, while thoracolumbar ROM was smaller in long-segment fixation than in short-segment fixation. In all models, the VMS was most significant at the screw-rod junction and greatest at the ribcage-vertebral body interface, partly explaining the high probability of internal fixation failure and prosthesis migration in these two positions.
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http://dx.doi.org/10.1186/s13018-021-02237-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845099PMC
January 2021

Evidence of nigericin as a potential therapeutic candidate for cancers: A review.

Biomed Pharmacother 2021 May 25;137:111262. Epub 2021 Jan 25.

Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. Electronic address:

Emerging studies have shown that nigericin, an H, K and Pb ionophore, has exhibited a promising anti-cancer activity in various cancers. However, its anti-cancer mechanisms have not been fully elucidated. In this review, the recent progresses on the use of nigericin in human cancers have been summarized. By exchanging H and K across cell membranes, nigericin shows promising anti-cancer activities in in vitro and in vivo as a single agent or in combination with other anti-cancer drugs through decreasing intracellular pH (pHi). The underlying mechanisms of nigericin also include the inactivation of Wnt/β-catenin signals, blockade of Androgen Receptor (AR) signaling, and activation of Stress-Activated Protein Kinase/c-Jun N-terminal Kinase (SAPK/JNK) signaling pathways. In many cancers, nigericin is proved to specifically target putative Cancer Stem Cells (CSCs), and its synergistic effects on photodynamic therapy are also reported. Other mechanisms of nigericin including influencing the mitochondrial membrane potentials, inducing an increase in drug accumulation and autophagy, controlling insulin accumulation in nuclei, and increasing the cytotoxic activity of liposome-entrapped drugs, are also discussed. Notably, the potential adverse effects such as teratogenic effects, insulin resistance and eryptosis shall not be ignored. Taken together, these reports suggest that treatment of cancer cells with nigericin may offer a novel therapeutic strategy and future potential of translation to clinics.
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http://dx.doi.org/10.1016/j.biopha.2021.111262DOI Listing
May 2021

Sustained-Release Method for the Directed Synthesis of ZIF-Derived Ultrafine Co-N-C ORR Catalysts with Embedded Co Quantum Dots.

ACS Appl Mater Interfaces 2020 Dec 18;12(52):57847-57858. Epub 2020 Dec 18.

College of New Energy, China University of Petroleum (East China), Qingdao 266580, P. R. China.

M-N-C catalysts with optimized local and external structures offer great potential for replacing expensive and labile Pt-based catalysts for the oxygen reduction reaction (ORR) in fuel cells. Herein, we report a novel and facile strategy of synthesizing ultrafine ZIF-derived Co-N-C catalysts by precisely controlling the crystallization rate of ZIFs. The employment of meta-soluble Co-doped basic zinc acetate (Co-BZA), which shows a sustained-release effect in solvents, allows for the control of the solubility of Co-BZA in solvents. Detailed investigations suggest that the solubility of Co-BZA in the solvent is the key for governing the grain size of the resulting Zn/Co bimetallic ZIFs. Therefore, the self-assembly process between ligands and metal ions can be regulated by tuning the composition of mixed solvents, thus enabling rational tuning of the grain size of the resulting ZIFs. One-step pyrolysis of the ultrafine Zn/Co bimetallic ZIF precursor leads to Co and N co-doped carbon with an ultrafine grain size (termed UF Co-N-C). The Co centers that are uniformly distributed in the carbon matrix possess a quantum-dot-level grain size. Furthermore, this type of carbon nanohybrid exhibits a hierarchical pore structure, as well as a high surface area. When used as an ORR catalyst, the UF Co-N-C catalyst possesses high ORR activity (with an of 0.9 V) that can rival 20 wt % commercial Pt/C (with an of 0.835 V) in alkaline media. Notably, this catalyst also displays strong ORR performance similar to that of Pt/C in acidic media. The superior durability and methanol tolerance in both alkaline and acidic media for UF Co-N-C compared to Pt/C illustrate its great potential in replacing commercial Pt/C catalysts. The outstanding ORR performance of UF Co-N-C could be attributed to the simultaneous optimization of both external structures and active sites, demonstrating the effectiveness of this strategy in constructing ORR catalysts with controlled structures and desired functionalities.
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http://dx.doi.org/10.1021/acsami.0c16081DOI Listing
December 2020

Clinical and imaging characteristics of breast ductal carcinoma in situ with microinvasion.

J Appl Clin Med Phys 2021 Jan 17;22(1):293-298. Epub 2020 Dec 17.

Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, 110004, China.

Background: We analyzed the clinical and imaging characteristics of patients with breast ductal carcinoma in situ with microinvasion (DCISM) and breast ductal carcinoma in situ (DCIS).

Methods: We analyzed the records of 40 patients diagnosed with DCISM and 61 patients with DCIS who were hospitalized at Shengjing Hospital (Shenyang, China) from January 2009 to June 2016. The size, hardness, and degree of calcification of tumors were determined by mammography and ultrasonography.

Results: In all, 37 DCISM patients and 45 DCIS patients showed clinical palpable masses (92.5% vs 73.77%, P = 0.018). Mammography showed that the mean size of tumor was larger in DCISM patients than that of DCIS patients (3.13 ± 1.51 vs 2.68 ± 1.77, P = 0.030). Ultrasound examination revealed calcification shadows in the solid tumor mass in 17 DCISM cases and 11 DCIS patients (42.5 vs 18.03%, P = 0.007). Furthermore, estrogen receptor positivity and progesterone receptor positivity were more common in DCIS patients (32.5% vs 54.10%, P = 0.033; 22.5% vs 45.90%, P = 0.017), and the percentage of menopausal patients were higher in DCISM patients than that of DCIS patients (70.00% vs 47.54%, P = 0.026).

Conclusion: Clinically palpable and calcified tumor masses on sonography are more commonly encountered in DCISM lesions.
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http://dx.doi.org/10.1002/acm2.13122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856492PMC
January 2021

New Perspectives for Resistance to PARP Inhibitors in Triple-Negative Breast Cancer.

Front Oncol 2020 25;10:578095. Epub 2020 Nov 25.

Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.

Poly (ADP-ribose) polymerase (PARP) inhibitors are a therapeutic milestone exerting a synthetic lethal effect in the treatment of cancer involving mutation. Theoretically, PARP inhibitors (PARPi) eliminate tumor cells by disrupting DNA damage repair through either PARylation or the homologous recombination (HR) pathway. However, resistance to PARPi greatly hinders therapeutic effectiveness in triple-negative breast cancer (TNBC). Owing to the high heterogeneity and few genetic targets in TNBC, there has been limited therapeutic progress in the past decades. In view of this, there is a need to circumvent resistance to PARPi and develop potential treatment strategies for TNBC. We present, herein, a review of the scientific progress and explore the mechanisms underlying PARPi resistance in TNBC. The complicated mechanisms of PARPi resistance, including drug exporter formation, loss of poly (ADP-ribose) glycohydrolase (PARG), HR reactivation, and restoration of replication fork stability, are discussed in detail in this review. Additionally, we also discuss new combination therapies with PARPi that can improve the clinical response in TNBC. The new perspectives for PARPi bring novel challenges and opportunities to overcome PARPi resistance in breast cancer.
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http://dx.doi.org/10.3389/fonc.2020.578095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724080PMC
November 2020

Modified minimally invasive surgical technique plus Bio-Oss Collagen for regenerative therapy of isolated interdental intrabony defects: study protocol for a randomised controlled trial.

BMJ Open 2020 12 10;10(12):e040046. Epub 2020 Dec 10.

Department of Periodontology, Peking University School and Hospital of Stomatology and National Engineering Laboratory for Digital and Material Technology of Stomatology and Beijing Key Laboratory of Digital Stomatology, Beijing, China

Introduction: Periodontal regeneration surgery has been widely used to deal with intrabony defects. Modified minimally invasive surgical technique (M-MIST) is designed to deal with isolated interdental intrabony defects, and has achieved satisfactory periodontal regenerative effect. Bio-Oss Collagen, as a bioactive material, has been applied for periodontal regeneration. It is similar to human cancellous bone, with the ability to promote bone formation; furthermore, it has exceptional plasticity and spatial stability. The combination of different materials and techniques has become a research hotspot in recent years. By combining the superiority of regeneration technology and materials, better regenerative effect can be achieved. This study will search for differences between M-MIST combined with Bio-Oss Collagen, and M-MIST alone in regeneration therapy for intrabony defects.

Methods And Analysis: The present research is designed as a two-group parallel randomised controlled trial. The total number of patients is 40. The patients will be randomly assigned to two groups, with 20 participants in each group, for further periodontal regenerative surgery. Test group: M-MIST plus Bio-Oss Collagen.

Control Group: M-MIST. After 12 months, the measurement indices will be recorded; these will include clinical attachment gain and radiographical intrabony defect depth change as the primary results, and secondary outcomes of full-mouth plaque scores, probing depth, full-mouth bleeding scores, gingival recession, mobility, gingival papilla height and Visual Analogue Scale. The paired samples t-test will be applied to detect any difference between baseline and 1-year registrations. A general linear model will be performed to study the relationship between the secondary and the primary outcome.

Ethics And Dissemination: The present research has received approval from the Ethics Committee of Peking University School and Hospital of Stomatology (PKUSSIRB-202053002). Data of the present research will be registered with the International Clinical Trials Registry Platform. Additionally, we will disseminate the results through scientific dental journals.

Trial Registration Number: ChiCTR-2000030851.

Protocol Version: Protocol Version 4, 14 July 2020.
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http://dx.doi.org/10.1136/bmjopen-2020-040046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733185PMC
December 2020

Unveiling the mechanism of structure-dependent thermal transport behavior in self-folded graphene film: a multiscale study.

Nanoscale 2020 Dec 26;12(47):24138-24145. Epub 2020 Nov 26.

School of Naval Architecture, Ocean and Civil Engineering (State Key Laboratory of Ocean Engineering), Shanghai Jiao Tong University, Shanghai 200240, China.

Understanding the relationship between the microstructures and overall properties is one of the basic concerns for material design and applications. As a ubiquitous structural configuration in nature, the folded morphology is also widely observed in graphene-based nanomaterials, namely grafold. Recently, a self-folded graphene film (SF-GF) material has been successfully fabricated by the assembly of grafolds and exhibits promising applications in thermal management. However, the dependence of thermal properties of SF-GF on the structural features of grafold has remained unclear. We here develop a theoretical model to describe the thermal transport behavior in SF-GF. Our model demonstrates the relationship between the fold length of grafolds and thermal properties of SF-GF. It serves as an efficient and portable tool to predict the temperature profile and thermal conductivity of SF-GF with good validations by large-scale molecular dynamics simulations. Using this model, we further study the evolution of thermal conductivity of SF-GF with the unfolding deformation during the stretch. Moreover, the effect of geometrical irregularity of grafolds is uncovered. The model developed in this work not only provides practical guidelines for the manipulation and design of thermal properties of SF-GF, but also benefits the understanding of thermal transport behaviors in other two-dimensional nanomaterials with folded structures.
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http://dx.doi.org/10.1039/d0nr06877bDOI Listing
December 2020

Recyclable Transition Metal Catalysis using Bipyridine-Functionalized SBA-15 by Co-condensation of Methallylsilane with TEOS.

Chem Asian J 2021 Feb 4;16(3):197-201. Epub 2021 Jan 4.

Department of Chemistry, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Well-defined recyclable Pd- and Rh-bipyridyl group-impregnated SBA-15 catalysts were prepared for C-C bond coupling reaction and selective hydrogenation reactions, respectively. These SBA-15 derived ligands for the catalysts were prepared by direct and indirect co-condensation method using bipyridyl-linked methallylsilane. This indirect method, involving methoxysilane generated from methallylsilane shows higher loading efficiency of transition metal catalysts on SBA-15 than the direct use of methallylsilane.
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http://dx.doi.org/10.1002/asia.202001152DOI Listing
February 2021

Circular RNA profiling identifies circ102049 as a key regulator of colorectal liver metastasis.

Mol Oncol 2021 Feb 29;15(2):623-641. Epub 2020 Dec 29.

Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, China.

Circular RNA (circRNA) plays an essential role in the development and progression of various cancers. However, the functions and mechanisms of circRNA in colorectal liver metastasis have not been fully elucidated. We performed circRNA microarray analysis to screen differentially expressed circRNA in the pathology of colorectal liver metastasis. Quantitative real-time PCR was used to detect the expression of hsa_circ_102049 (circ102049) in colorectal cancer (CRC) samples. CRC cells were transfected with circ102049 overexpression vector or small interfering (si)RNA to assess the effects of circ102049 in vitro. Bioinformatics analysis, fluorescence in situ hybridization, RNA immunoprecipitation, RNA pull-down and luciferase reporter assays were conducted to confirm the relationship of circ102049, miR-761, miR-192-3p and FRAS1. The mechanism by which circ102049 recruits and distributes DGCR8 protein in the cytoplasm was also investigated. We found that circ102049 was highly expressed in primary CRC tumors with liver metastasis and closely correlated with the prognosis of patients with CRC. Circ102049 significantly enhanced the adhesion, migration and invasion abilities of CRC cells, and promoted CRC progression via a micro (mi)R-761/miR-192-3p-FRAS1-dependent mechanism. Notably, due to the distribution of DGCR8 protein, circ102049 may also indirectly reduce the levels of mature miR-761 and miR-192-3p in the cytoplasm. In addition, the role of circ102049 in promoting colorectal liver metastasis was confirmed in vivo. Our findings provide new evidence that circ102049 may be a potential prognostic factor in CRC, and that the circ102049-miR-761/miR-192-3p-FRAS1 axis may be an anti-metastatic target for CRC patients.
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http://dx.doi.org/10.1002/1878-0261.12840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858140PMC
February 2021

Ultra-broadband large-angle beam splitter based on a homogeneous metasurface at visible wavelengths.

Opt Express 2020 Oct;28(21):32226-32238

Metasurface-based beam splitters with high efficiency, large split angle, wide bandwidth and easy fabrication are highly desirable and still in pursuit. In this paper, we propose a heuristic scheme for designing an ultra-broadband high-efficiency power beam splitter based on a homogeneous metasurface. The conversion efficiency and total transmission intensity of the power splitter stays higher than 95% and 0.66 within the wavelength region from 604 nm to 738 nm, respectively. Particularly, the conversion efficiency can maintain greater than 99% in 58 nm bandwidth. The angle between two split beams can reach a maximum of 157.82° at the wavelength of 738 nm. In addition to simplified design and easy fabrication, the proposed power beam splitter possesses high robustness as well. We expect that our design can pave a new way for realizing high-performance metasurface-based beam splitters.
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http://dx.doi.org/10.1364/OE.405375DOI Listing
October 2020

Retraction Note: LncRNA TUG1 was upregulated in osteoporosis and regulates the proliferation and apoptosis of osteoclasts.

J Orthop Surg Res 2020 Oct 12;15(1):469. Epub 2020 Oct 12.

Department of Orthopaedics, Baoding First Central Hospital, No. 320, Great Wall North Street, Baoding City, 071000, Hebei Province, People's Republic of China.

An amendment to this paper has been published and can be accessed via the original article.
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http://dx.doi.org/10.1186/s13018-020-02000-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552464PMC
October 2020

Characterization of Low Molecular Weight Sulfate Ulva Polysaccharide and its Protective Effect against IBD in Mice.

Mar Drugs 2020 Sep 29;18(10). Epub 2020 Sep 29.

Marine Biomedical Research Institute of Qingdao, Qingdao 266071, China.

Inflammatory bowel disease (IBD) has been gradually considered a public health challenge worldwide. Sulfated polysaccharides, extracted from seaweed, have been shown to have an anti-inflammatory effect on the disease[...].
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http://dx.doi.org/10.3390/md18100499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601132PMC
September 2020

Changes in the expression of matrix metalloproteinase-9 after intense pulsed light therapy combined with meibomian gland expression in moderate and severe meibomian gland dysfunction.

Cont Lens Anterior Eye 2020 Sep 15:101339. Epub 2020 Sep 15.

Department of Ophthalmology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, South Korea. Electronic address:

Purpose: To evaluate the combined effect of intense pulsed light (IPL) therapy and meibomian gland expression on extracellular matrix metalloproteinase-9 (MMP-9) levels and clinical outcomes of moderate and severe meibomian gland dysfunction (MGD) treatment.

Methods: This retrospective study was conducted on 45 eyes of 23 patients with moderate and severe MGD. Each eye underwent three IPL sessions and meibomian gland expression at 2-week intervals. In this study the evaluated parameters included tear film break-up time (TBUT), corneal and conjunctival fluorescein staining scores, biomicroscopic examination of lid margins and meibomian glands, ocular surface disease index (OSDI) questionnaire score, and extracellular MMP-9 levels using the immunoassay device before and two weeks after the last treatment session. Linear mixed model and generalized estimating equations model were used to evaluate possible differences.

Results: There were significant improvements in TBUT (P < 0.001), SICCA ocular staining score (P = 0.008), Oxford staining score (P = 0.023), lid margin irregularity (P < 0.001 for upper and lower eyelids), lid thickness (P < 0.001 for upper and lower eyelids), meibomian gland plugging (P = 0.010 and P = 0.012 for upper and lower eyelids), meibum color (P = 0.044 and P < 0.001 for upper and lower eyelids), meibum consistency (P < 0.001 for upper and lower eyelids), MGD grade (P < 0.001), and OSDI questionnaire score (P < 0.001). Incidence of positive results for MMP-9 immunoassay significantly decreased from 84.0% to 56.0% (P = 0.031) after treatment.

Conclusion: In patients with moderate to severe MGD, three sessions of IPL combined with meibomian gland expression improved objective findings, subjective symptoms, meibomian gland function, and MMP-9 immunoassay results. The results support the combination of IPL and meibomian gland expression for treating moderate to severe MGD.
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http://dx.doi.org/10.1016/j.clae.2020.05.008DOI Listing
September 2020

An electrochemical aptasensor based on cocoon-like DNA nanostructure signal amplification for the detection of O157:H7.

Analyst 2020 Nov;145(22):7340-7348

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.

We developed an electrochemical aptasensor based on cocoon-like DNA nanostructures as signal tags for highly sensitive and selective detection of Escherichia coli O157:H7. The stable cocoon-like DNA nanostructures synthesized by the rolling circle amplification reaction were loaded with hemin as electrochemical signal tags to amplify the signals. The single-stranded DNA capture probes were modified on the surface of a Au electrode via a Au-S bond. The E. coli O157:H7 specific aptamer and capture probe formed double-stranded DNA structures on the Au electrode. The aptamer preferentially bound to E. coli O157:H7, causing the dissociation of some aptamer-capture probes and releasing some capture probes. Subsequently, the free capture probes hybridized with the DNA nanostructures through the cDNA sequence. Under optimal conditions, the change in the electrochemical signal was proportional to the logarithm of E. coli O157:H7 concentration, from 10 to 106 CFU mL-1, and the detection limit was estimated to be 10 CFU mL-1. The electrochemical aptasensor could be readily used to detect various pathogenic bacteria and to provide a new method of early diagnosis of pathogenic microorganisms.
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http://dx.doi.org/10.1039/d0an01258kDOI Listing
November 2020

Functional Identification of the Dextransucrase Gene of DRP105.

Int J Mol Sci 2020 Sep 9;21(18). Epub 2020 Sep 9.

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.

DRP105 isolated from Chinese sauerkraut juice is an intensive producer of dextran. We report the complete genome sequence of DRP105. This strain contains a dextransucrase gene () involved in the production of dextran, possibly composed of glucose monomers. To explore the dextran synthesis mechanism of DRP105, we constructed a -deficient strain derived from DRP105 using the Cre-loxP recombination system. The secondary structure prediction results showed that DRP105 dextransucrase (Dsr) was coded by and contained 17.07% -helices, 29.55% -sheets, 10.18% -turns, and 43.20% random coils. We also analyzed the dextran yield, monosaccharide change, organic acid, and amino-acid content of DRP105 and DRP105-. The result showed that the lack of changed the DRP105 sugar metabolism pathway, which in turn affected the production of metabolites.
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http://dx.doi.org/10.3390/ijms21186596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555554PMC
September 2020

Beyond dipole excitation: the performance of quadrupole-based Huygens' metasurface.

Opt Lett 2020 Sep;45(17):4847-4850

Due to the utilization of overlapped dipole resonances, traditional Huygens' metasurfaces suffer from dipole interactions. In this Letter, we propose a design of phase-gradient Huygens' metasurface based on the quadrupole resonances excited in the cross-shaped structures. The quadrupole resonances are theoretically shown insensitive to the quadrupole interactions. Benefiting from this intrinsic property, the proposed metasurface can well suppress element interaction influence and exhibits some impressive properties, including the ability to suppress high diffraction orders, tunable anomalous refractive angles, and high transmission efficiency. The numerical results show promising potential for quadrupole resonances to be applied in advanced Huygens' metasurface designs.
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http://dx.doi.org/10.1364/OL.400874DOI Listing
September 2020

Molecular Screening for Nigericin Treatment in Pancreatic Cancer by High-Throughput RNA Sequencing.

Front Oncol 2020 31;10:1282. Epub 2020 Jul 31.

Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Shanghai, China.

Nigericin, an antibiotic derived from , has been proved to exhibit promising anti-cancer effects on a variety of cancers. Our previous study investigated the potential anti-cancer properties in pancreatic cancer (PC), and demonstrated that nigericin could inhibit the cell viabilities in concentration- and time-dependent manners via differentially expressed circular RNAs (circRNAs). However, the knowledge of nigericin associated with long non-coding RNA (lncRNA) and mRNA in pancreatic cancer (PC) has not been studied. This study is to elucidate the underlying mechanism from the perspective of lncRNA and mRNA. The continuously varying molecules (lncRNAs and mRNAs) were comprehensively screened by high-throughput RNA sequencing. Our data showed that 76 lncRNAs and 172 mRNAs were common differentially expressed in the nigericin anti-cancer process. Subsequently, the bioinformatics analyses, including Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, coding and non-coding co-expression network, cis- and trans-regulation predictions and protein-protein interaction (PPI) network, were applied to annotate the potential regulatory mechanisms among these coding and non-coding RNAs during the nigericin anti-cancer process. These findings provided new insight into the molecular mechanism of nigericin toward cancer cells, and suggested a possible clinical application in PC.
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http://dx.doi.org/10.3389/fonc.2020.01282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411259PMC
July 2020

Effects of calcium treatment on malate metabolism and γ-aminobutyric acid (GABA) pathway in postharvest apple fruit.

Food Chem 2021 Jan 5;334:127479. Epub 2020 Jul 5.

College of Horticulture, Northwest A&F University, Yangling, Shaanxi 712100, China. Electronic address:

Calcium treatment effects on malate metabolism and the GABA pathway in 'Cripps Pink' apple fruit during storage were investigated. Postharvest apple fruit treated with 1% and 4% calcium chloride solutions were stored at 25 ± 1 °C. The 4% calcium treatment suppressed declines in titratable acidity and malate content and increased succinate and oxalate concentrations. Calcium treatment also reduced the respiration rate and decreased ethylene production peak during storage. Moreover, 4% calcium treatment significantly enhanced cyNAD-MDH and PEPC activities and upregulated MdMDH1, MdMDH2, MdPEPC1 and MdPEPC2 expression while inhibiting cyNADP-ME and PEPCK activities and downregulating MdME1, MdME4 and MdPEPCK2 expression. Surprisingly, calcium treatment changed the content of some free amino acids (GABA, proline, alanine, aspartic acid and glutamate), two of which (glutamate and GABA) are primary metabolites of the GABA pathway. Furthermore, calcium application enhanced GABA pathway activity by increasing MdGAD1, MdGAD2, MdGABA-T1/2 and MdSSADH transcript levels.
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http://dx.doi.org/10.1016/j.foodchem.2020.127479DOI Listing
January 2021

Who may benefit from lower dosages of intravenous tissue plasminogen activator? Results from a cluster data analysis.

Stroke Vasc Neurol 2020 12 1;5(4):348-352. Epub 2020 Jul 1.

Department of Neurology, Huashan Hospital Fudan University, Shanghai, Shanghai, China

Background: The risk of symptomatic intracranial haemorrhage (sICH) after thrombolysis is low but severe. Lower dose of alteplase may reduce the risk of sICH. We aim to identify subsets of patients who could benefit from lower dose of alteplase compared with standard dose.

Methods: Data from two observational registries were pooled together. A total of 3479 patients who had acute ischaemic stroke were entered into the interaction tree model. The response variable was the rate of sICH per the definition of the National Institute of Neurological Disorders and Stroke Study. Clinical improvement was measured by the National Institutes of Health Stroke Scale (NIHSS) and defined as NIHSS 0 or 1 or an improvement of more than 4 points (within 7 days or at discharge). Rare event logistic regression was performed to analyse the OR of safety outcome.

Results: To optimise the interaction effect between tissue plasminogen activator (tPA) dosage (standard/lower) and patient subgroups, three subgroups based on the severity of stroke were identified: (1) NIHSS ≤4, (2) NIHSS between 5 and 14, and (3) NIHSS ≥15. The estimated difference of OR of having sICH was 2.71 (95% CI 0.80 to 7.69, p=0.10) for mild, 0.13 (95% CI 0.02 to 0.68, p=0.01) for moderate, and 0.65 (95% CI 0.19 to 2.55, p=0.52) for severe, respectively. In addition, patients who had moderate stroke treated with lower dose had comparable efficacy outcome (OR 1.23, 95% CI 0.71 to 2.13, p=0.45).

Conclusion: Our analysis demonstrated that in patients who had moderate stroke, lower doses of alteplase are associated with significant sICH reduction and non-inferior performance in efficacy, compared with those in the standard dose group.

Trial Registration Number: The TIMS-China was a national prospective stroke registry on thrombolytic therapy using intravenous tPA in patients who had acute ischaemic stroke. The results were initially published in 2012 without a clinical trial registration number. The Shanghai Stroke Service System was registered at www.clinicaltrial.gov (NCT02735226).
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http://dx.doi.org/10.1136/svn-2020-000388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804063PMC
December 2020