Yatrik M Shah

Yatrik M Shah

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Yatrik M Shah

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Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis.

Cell Metab 2020 Jan 7;31(1):115-130.e6. Epub 2019 Nov 7.

Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949377PMC
January 2020

Impact of dietary manganese on experimental colitis in mice.

FASEB J 2019 Dec 29. Epub 2019 Dec 29.

Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1096/fj.201902396RDOI Listing
December 2019

Adrenoceptor-related decrease in serum triglycerides is independent of PPARα activation.

FEBS J 2019 Nov 28;286(21):4328-4341. Epub 2019 Jun 28.

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/febs.14966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829030PMC
November 2019

A genetic mouse model of severe iron deficiency anemia reveals tissue-specific transcriptional stress responses and cardiac remodeling.

J Biol Chem 2019 Oct 15;294(41):14991-15002. Epub 2019 Aug 15.

Department of Molecular & Integrative Physiology, and Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109

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http://dx.doi.org/10.1074/jbc.RA119.009578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791316PMC
October 2019

Functions and Implications of Autophagy in Colon Cancer.

Cells 2019 Oct 30;8(11). Epub 2019 Oct 30.

Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.3390/cells8111349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912527PMC
October 2019

Medullary thymic epithelial NF-kB-inducing kinase (NIK)/IKKα pathway shapes autoimmunity and liver and lung homeostasis in mice.

Proc Natl Acad Sci U S A 2019 Sep 3;116(38):19090-19097. Epub 2019 Sep 3.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109;

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http://dx.doi.org/10.1073/pnas.1901056116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754592PMC
September 2019

Temporal induction of intestinal epithelial hypoxia-inducible factor-2α is sufficient to drive colitis.

Am J Physiol Gastrointest Liver Physiol 2019 Aug 26;317(2):G98-G107. Epub 2019 Jun 26.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1152/ajpgi.00081.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734372PMC
August 2019

Hypoxic Regulation of Neutrophils in Cancer.

Int J Mol Sci 2019 Aug 27;20(17). Epub 2019 Aug 27.

Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.3390/ijms20174189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747474PMC
August 2019

Notch and mTOR Signaling Pathways Promote Human Gastric Cancer Cell Proliferation.

Neoplasia 2019 07 24;21(7):702-712. Epub 2019 May 24.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14765586193006
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http://dx.doi.org/10.1016/j.neo.2019.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536707PMC
July 2019

Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment.

Cell Death Dis 2019 Jul 18;10(8):544. Epub 2019 Jul 18.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University; Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, China.

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http://dx.doi.org/10.1038/s41419-019-1757-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639417PMC
July 2019

A PHD in immunosuppression: oxygen-sensing pathways regulate immunosuppressive Tregs.

J Clin Invest 2019 Jul 29;130:3524-3526. Epub 2019 Jul 29.

Rogel Cancer Center.

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http://dx.doi.org/10.1172/JCI130009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715354PMC
July 2019

Enhancing career development of postdoctoral trainees: act locally and beyond.

J Physiol 2019 May 31;597(9):2317-2322. Epub 2019 Mar 31.

Office of Graduate & Postdoctoral Studies, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1113/JP277684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487921PMC
May 2019

Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice.

Gastroenterology 2019 Apr 11;156(5):1467-1482. Epub 2018 Dec 11.

Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan; Internal Medicine Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, Michigan. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441634PMC
April 2019

Myc-Associated Zinc Finger Protein Regulates the Proinflammatory Response in Colitis and Colon Cancer via STAT3 Signaling.

Mol Cell Biol 2018 11 29;38(22). Epub 2018 Oct 29.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA

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http://dx.doi.org/10.1128/MCB.00386-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206459PMC
November 2018

Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases.

Elife 2018 08 2;7. Epub 2018 Aug 2.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, United States.

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http://dx.doi.org/10.7554/eLife.34152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078493PMC
August 2018

Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis.

Nat Commun 2018 07 16;9(1):2751. Epub 2018 Jul 16.

Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.

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http://dx.doi.org/10.1038/s41467-018-05309-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048127PMC
July 2018

HIF1-alpha Regulates Acinar Cell Function and Response to Injury in Mouse Pancreas.

Gastroenterology 2018 05 1;154(6):1630-1634.e3. Epub 2018 Feb 1.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan; Åbo Akademi University, Turku, Finland.

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http://dx.doi.org/10.1053/j.gastro.2018.01.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927829PMC
May 2018

Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance.

EBioMedicine 2018 May 27;31:202-216. Epub 2018 Apr 27.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, People's Republic of China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23523964183015
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http://dx.doi.org/10.1016/j.ebiom.2018.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013933PMC
May 2018

Genetic neutrophil deficiency ameliorates cerebral ischemia-reperfusion injury.

Exp Neurol 2017 12 31;298(Pt A):104-111. Epub 2017 Aug 31.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, United States; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, MI 48109, United States; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00144886173022
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http://dx.doi.org/10.1016/j.expneurol.2017.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658240PMC
December 2017

Dual modulation of human hepatic zonation via canonical and non-canonical Wnt pathways.

Exp Mol Med 2017 12 15;49(12):e413. Epub 2017 Dec 15.

Division of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/emm.2017.226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750478PMC
December 2017

A central role for hypoxia-inducible factor (HIF)-2α in hepatic glucose homeostasis.

Nutr Healthy Aging 2017 Dec 7;4(3):207-216. Epub 2017 Dec 7.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.

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http://dx.doi.org/10.3233/NHA-170022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734117PMC
December 2017

Indian Hedgehog Suppresses Intestinal Inflammation.

Cell Mol Gastroenterol Hepatol 2018 31;5(1):63-64. Epub 2017 Oct 31.

Department of Internal Medicine, Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1016/j.jcmgh.2017.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736880PMC
October 2017

Iron elevation and adipose tissue remodeling in the epididymal depot of a mouse model of polygenic obesity.

PLoS One 2017 26;12(6):e0179889. Epub 2017 Jun 26.

School of Kinesiology, University of Michigan, 1402 Washington Hts., Ann Arbor, MI, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179889PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484604PMC
September 2017

Epithelial Hypoxia-Inducible Factor 2α Facilitates the Progression of Colon Tumors through Recruiting Neutrophils.

Mol Cell Biol 2017 03 15;37(5). Epub 2017 Feb 15.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA

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http://dx.doi.org/10.1128/MCB.00481-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311236PMC
March 2017

Regulation and function of bone morphogenetic protein signaling in colonic injury and inflammation.

Am J Physiol Gastrointest Liver Physiol 2017 01 17;312(1):G24-G33. Epub 2016 Nov 17.

Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan;

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http://dx.doi.org/10.1152/ajpgi.00169.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283904PMC
January 2017

Role of Intestinal HIF-2α in Health and Disease.

Annu Rev Physiol 2016 19;78:301-25. Epub 2015 Nov 19.

Department of Molecular & Integrative Physiology and.

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http://dx.doi.org/10.1146/annurev-physiol-021115-105202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809193PMC
December 2016

The role of hypoxia in intestinal inflammation.

Authors:
Yatrik M Shah

Mol Cell Pediatr 2016 Dec 26;3(1). Epub 2016 Jan 26.

Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.

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http://dx.doi.org/10.1186/s40348-016-0030-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728161PMC
December 2016

Mitochondrial Amino Acid Metabolism Provides Vulnerabilities in Mutant KRAS-Driven Cancers.

Gastroenterology 2016 11 3;151(5):798-801. Epub 2016 Oct 3.

Department of Molecular and Integrative Physiology and Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.09.036DOI Listing
November 2016

Hypoxia-inducible factors: a central link between inflammation and cancer.

J Clin Invest 2016 10 15;126(10):3689-3698. Epub 2016 Aug 15.

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http://dx.doi.org/10.1172/JCI84430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096825PMC
October 2016

Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis.

Cell Metab 2016 09 18;24(3):447-461. Epub 2016 Aug 18.

Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023486PMC
September 2016

Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera.

Blood 2016 07 6;128(2):265-76. Epub 2016 May 6.

Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA; Division of Hematology-Oncology, Department of Pediatrics, Weill Cornell Medical College, New York, NY; Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY; and Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1182/blood-2015-10-676742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946204PMC
July 2016

Neurotensin Promotes the Development of Colitis and Intestinal Angiogenesis via Hif-1α-miR-210 Signaling.

J Immunol 2016 05 13;196(10):4311-21. Epub 2016 Apr 13.

Inflammatory Bowel Disease Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095;

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http://dx.doi.org/10.4049/jimmunol.1501443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868643PMC
May 2016

PPARα (Peroxisome Proliferator-activated Receptor α) Activation Reduces Hepatic CEACAM1 Protein Expression to Regulate Fatty Acid Oxidation during Fasting-refeeding Transition.

J Biol Chem 2016 Apr 4;291(15):8121-9. Epub 2016 Feb 4.

From the Center for Diabetes and Endocrine Research and Department of Physiology and Pharmacology, College of Medicine and Life Sciences, University of Toledo, Health Science Campus, Toledo, Ohio 43614, Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701

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http://dx.doi.org/10.1074/jbc.M116.714014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825014PMC
April 2016

HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling.

Cell Metab 2016 Mar 4;23(3):505-16. Epub 2016 Feb 4.

Departments of Molecular & Integrative Physiology, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785079PMC
March 2016

Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis.

Elife 2016 Feb 25;5:e12204. Epub 2016 Feb 25.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, United States.

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http://dx.doi.org/10.7554/eLife.12204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805551PMC
February 2016

Fatty acid binding protein-4 (FABP4) is a hypoxia inducible gene that sensitizes mice to liver ischemia/reperfusion injury.

J Hepatol 2015 Oct 10;63(4):855-62. Epub 2015 Jun 10.

Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA; Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.05.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867094PMC
October 2015

Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1.

Sci Signal 2015 Oct 6;8(397):ra98. Epub 2015 Oct 6.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1126/scisignal.aac5418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818013PMC
October 2015

c-Kit as a Novel Potential Therapeutic Target in Colorectal Cancer.

Gastroenterology 2015 Sep 27;149(3):534-7. Epub 2015 Jul 27.

Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology & Hepatology, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1053/j.gastro.2015.07.027DOI Listing
September 2015

Intestine-specific Disruption of Hypoxia-inducible Factor (HIF)-2α Improves Anemia in Sickle Cell Disease.

J Biol Chem 2015 Sep 19;290(39):23523-7. Epub 2015 Aug 19.

From the Department of Molecular and Integrative Physiology, Department of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, Michigan 48109 and

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http://www.jbc.org/lookup/doi/10.1074/jbc.C115.681643
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http://dx.doi.org/10.1074/jbc.C115.681643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583015PMC
September 2015

Maternal intestinal HIF-2α is necessary for sensing iron demands of lactation in mice.

Proc Natl Acad Sci U S A 2015 Jul 29;112(28):E3738-47. Epub 2015 Jun 29.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109; Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109

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http://dx.doi.org/10.1073/pnas.1504891112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507236PMC
July 2015

Transgenic mouse models for alcohol metabolism, toxicity, and cancer.

Adv Exp Med Biol 2015 ;815:375-87

Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA.

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http://dx.doi.org/10.1007/978-3-319-09614-8_22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323349PMC
March 2015

Bacterial siderophores that evade or overwhelm lipocalin 2 induce hypoxia inducible factor 1α and proinflammatory cytokine secretion in cultured respiratory epithelial cells.

Infect Immun 2014 Sep 30;82(9):3826-36. Epub 2014 Jun 30.

Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA

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http://dx.doi.org/10.1128/IAI.01849-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187820PMC
September 2014

PPARα-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate.

Am J Physiol Gastrointest Liver Physiol 2014 Sep 17;307(5):G564-73. Epub 2014 Jul 17.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; and

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http://dx.doi.org/10.1152/ajpgi.00153.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154119PMC
September 2014

PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis.

Nat Commun 2014 Sep 3;5:4573. Epub 2014 Sep 3.

State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Tongjiaxiang 24, Nanjing 21009, China.

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http://dx.doi.org/10.1038/ncomms5573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164778PMC
September 2014

Hypoxia-inducible factor/MAZ-dependent induction of caveolin-1 regulates colon permeability through suppression of occludin, leading to hypoxia-induced inflammation.

Mol Cell Biol 2014 Aug 2;34(16):3013-23. Epub 2014 Jun 2.

Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA Department of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, Michigan, USA

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http://dx.doi.org/10.1128/MCB.00324-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135598PMC
August 2014

Activation of HIF-1α does not increase intestinal tumorigenesis.

Am J Physiol Gastrointest Liver Physiol 2014 Jul 29;307(2):G187-95. Epub 2014 May 29.

Departments of Molecular and Integrative Physiology and Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, Michigan

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http://dx.doi.org/10.1152/ajpgi.00112.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101679PMC
July 2014

Biomarkers of coordinate metabolic reprogramming in colorectal tumors in mice and humans.

Gastroenterology 2014 May 15;146(5):1313-24. Epub 2014 Jan 15.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992178PMC
May 2014

Role of PPARα and HNF4α in stress-mediated alterations in lipid homeostasis.

PLoS One 2013 14;8(8):e70675. Epub 2013 Aug 14.

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070675PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743822PMC
March 2014

Hypoxia-inducible factors link iron homeostasis and erythropoiesis.

Gastroenterology 2014 Mar 31;146(3):630-42. Epub 2013 Dec 31.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1053/j.gastro.2013.12.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943938PMC
March 2014

Role of Myc in hepatocellular proliferation and hepatocarcinogenesis.

J Hepatol 2014 Feb 2;60(2):331-8. Epub 2013 Oct 2.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2013.09.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909877PMC
February 2014

Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia.

Proc Natl Acad Sci U S A 2013 Dec 26;110(50):E4922-30. Epub 2013 Nov 26.

Department of Molecular and Integrative Physiology and Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109.

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http://dx.doi.org/10.1073/pnas.1314197110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864280PMC
December 2013

Cholestasis induces reversible accumulation of periplakin in mouse liver.

BMC Gastroenterol 2013 Jul 13;13:116. Epub 2013 Jul 13.

Biofrontier Platform, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

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http://dx.doi.org/10.1186/1471-230X-13-116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716950PMC
July 2013

Intestinal iron homeostasis and colon tumorigenesis.

Nutrients 2013 Jun 28;5(7):2333-51. Epub 2013 Jun 28.

Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.3390/nu5072333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738976PMC
June 2013

In vitro organoid culture of primary mouse colon tumors.

J Vis Exp 2013 May 17(75):e50210. Epub 2013 May 17.

Department of Molecular & Integrative Physiology, University of Michigan, USA.

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http://dx.doi.org/10.3791/50210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684363PMC
May 2013

Hypoxia-inducible factor 1α regulates a SOCS3-STAT3-adiponectin signal transduction pathway in adipocytes.

J Biol Chem 2013 Feb 19;288(6):3844-57. Epub 2012 Dec 19.

Laboratory of Metabolism, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1074/jbc.M112.426338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567639PMC
February 2013

Hypoxia-inducible factor-2α is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer.

Carcinogenesis 2013 Jan 5;34(1):163-9. Epub 2012 Oct 5.

Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1093/carcin/bgs313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534191PMC
January 2013

Iron homeostasis in the liver.

Compr Physiol 2013 Jan;3(1):315-30

Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1002/cphy.c120016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936199PMC
January 2013

Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis.

Cell Metab 2012 Nov;16(5):634-44

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cmet.2012.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496181PMC
November 2012

Analysis of the peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) cistrome reveals novel co-regulatory role of ATF4.

BMC Genomics 2012 Nov 24;13:665. Epub 2012 Nov 24.

Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.

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http://dx.doi.org/10.1186/1471-2164-13-665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556323PMC
November 2012

The hypoxia-inducible factor-C/EBPα axis controls ethanol-mediated hepcidin repression.

Mol Cell Biol 2012 Oct 6;32(19):4068-77. Epub 2012 Aug 6.

Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1128/MCB.00723-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457545PMC
October 2012

Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity.

Hepatology 2012 Jul 6;56(1):281-90. Epub 2012 Jun 6.

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20814, USA.

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http://doi.wiley.com/10.1002/hep.25645
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http://dx.doi.org/10.1002/hep.25645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378765PMC
July 2012

Pregnane X receptor as a target for treatment of inflammatory bowel disorders.

Trends Pharmacol Sci 2012 Jun 18;33(6):323-30. Epub 2012 May 18.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.tips.2012.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368991PMC
June 2012

Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis.

Cancer Res 2012 May 14;72(9):2285-93. Epub 2012 Mar 14.

Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342485PMC
May 2012

The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention.

Nat Rev Cancer 2012 Feb 9;12(3):181-95. Epub 2012 Feb 9.

Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.

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http://www.nature.com/articles/nrc3214
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http://dx.doi.org/10.1038/nrc3214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322353PMC
February 2012

Disruption of endothelial peroxisome proliferator-activated receptor γ accelerates diet-induced atherogenesis in LDL receptor-null mice.

Arterioscler Thromb Vasc Biol 2012 Jan 20;32(1):65-73. Epub 2011 Oct 20.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20814, USA.

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http://dx.doi.org/10.1161/ATVBAHA.111.239137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649072PMC
January 2012

Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis.

Hepatology 2011 Aug 26;54(2):472-83. Epub 2011 Jun 26.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1002/hep.24400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145012PMC
August 2011

Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice.

Gastroenterology 2011 Jun 17;140(7):2044-55. Epub 2011 Mar 17.

Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor Michigan, USA.

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http://dx.doi.org/10.1053/j.gastro.2011.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109109PMC
June 2011

Intestinal hypoxia-inducible factor-2alpha (HIF-2alpha) is critical for efficient erythropoiesis.

J Biol Chem 2011 Jun 15;286(22):19533-40. Epub 2011 Apr 15.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48108, USA.

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http://dx.doi.org/10.1074/jbc.M111.238667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103332PMC
June 2011

Fibrinogen-γ proteolysis and solubility dynamics during apoptotic mouse liver injury: heparin prevents and treats liver damage.

Hepatology 2011 Apr;53(4):1323-32

Molecular & Integrative Physiology, University of Michigan Medical School, 1137 Catherine Street, 7744 Med Sci II, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1002/hep.24203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079287PMC
April 2011

PPARalpha-dependent activation of cell cycle control and DNA repair genes in hepatic nonparenchymal cells.

Toxicol Sci 2010 Dec 2;118(2):404-10. Epub 2010 Sep 2.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1093/toxsci/kfq259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984533PMC
December 2010

Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation.

J Pharmacol Exp Ther 2010 Oct 13;335(1):32-41. Epub 2010 Jul 13.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1124/jpet.110.170225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957776PMC
October 2010

Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity.

Chem Res Toxicol 2009 Apr;22(4):699-707

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1021/tx800464qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670930PMC
April 2009

Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency.

Cell Metab 2009 Feb 15;9(2):152-64. Epub 2009 Jan 15.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659630PMC
http://dx.doi.org/10.1016/j.cmet.2008.12.012DOI Listing
February 2009

A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4.

Drug Metab Dispos 2008 Dec 17;36(12):2506-12. Epub 2008 Sep 17.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.108.022723
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http://dx.doi.org/10.1124/dmd.108.022723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678901PMC
December 2008

Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease.

Inflamm Bowel Dis 2008 Jul;14(7):908-20

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1002/ibd.20413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435391PMC
July 2008

Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade.

Gastroenterology 2008 Jun 10;134(7):2036-48, 2048.e1-3. Epub 2008 Mar 10.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1053/j.gastro.2008.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533811PMC
June 2008

PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators.

Toxicology 2008 Apr 7;246(1):2-8. Epub 2007 Oct 7.

National Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.tox.2007.09.030DOI Listing
April 2008