Publications




Increased fibrosis and impaired intratumoral accumulation of macromolecules in a murine model of pancreatic cancer co-administered with FGF-2.
J Control Release 2016 May 12;230:109-15. Epub 2016 Apr 12.
Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-Naka, Kita-ku, Okayama-shi, Okayama 700-8530, Japan. Electronic address:


Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance.
Cell 2015 Nov;163(4):975-87
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; Takayanagi Osteonetwork Project, Exploratory Research for Advanced Technology Program, Japan Science and Technology Agency (JST), Tokyo 113-0033, Japan. Electronic address:

Loss of lymph node fibroblastic reticular cells and high endothelial cells is associated with humoral immunodeficiency in mouse graft-versus-host disease.
J Immunol 2015 Jan 24;194(1):398-406. Epub 2014 Nov 24.
Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo 102-0076, Japan;

5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.
Cell Rep 2014 Oct 2;9(1):48-60. Epub 2014 Oct 2.
Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. Electronic address:

An integrative analysis of the tumorigenic role of TAZ in human non-small cell lung cancer.
Clin Cancer Res 2014 Sep 20;20(17):4660-72. Epub 2014 Jun 20.
Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.


PCDH10 is required for the tumorigenicity of glioblastoma cells.
Biochem Biophys Res Commun 2014 Jan 6;444(1):13-8. Epub 2014 Jan 6.
Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. Electronic address:


Erlotinib prolongs survival in pancreatic cancer by blocking gemcitabine-induced MAPK signals.
Cancer Res 2013 Apr 1;73(7):2221-34. Epub 2013 Feb 1.
Department of Gastroetnterology, Graduate School of Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.


Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway.
Nat Commun 2011 Nov 22;2:548. Epub 2011 Nov 22.
Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.



LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis.
Blood 2010 Dec 16;116(23):5060-70. Epub 2010 Aug 16.
Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

Exogenous introduction of tissue inhibitor of metalloproteinase 2 reduces accelerated growth of TGF-β-disrupted diffuse-type gastric carcinoma.
Cancer Sci 2010 Nov;101(11):2398-403
Department of Molecular Pathology and the Global Center of Excellence Program for Integrative Life Science Based on the Study of Biosignaling Mechanisms, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

The G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor.
Proc Natl Acad Sci U S A 2010 Oct 20;107(40):17309-14. Epub 2010 Sep 20.
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.

Enhanced magnetic resonance imaging of experimental pancreatic tumor in vivo by block copolymer-coated magnetite nanoparticles with TGF-beta inhibitor.
J Control Release 2009 Dec 12;140(3):306-11. Epub 2009 Jun 12.
Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.




COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction.
Genes Cells 2009 Mar 4;14(3):425-34. Epub 2009 Feb 4.
Department of Molecular Pathology, Graduate School of Medicine,Global Center of Excellence Program for Integrative Life Science Based on the Study of Biosignaling Mechanisms, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

Comparison of the effects of the kinase inhibitors imatinib, sorafenib, and transforming growth factor-beta receptor inhibitor on extravasation of nanoparticles from neovasculature.
Cancer Sci 2009 Jan 24;100(1):173-80. Epub 2008 Nov 24.
Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Analysis of blood flow in a third ventricular ependymoma and an olfactory bulb meningioma by using perfusion computed tomography.
J Vet Med Sci 2008 Sep;70(9):981-3
Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.

Periostin is expressed in pericryptal fibroblasts and cancer-associated fibroblasts in the colon.
J Histochem Cytochem 2008 Aug 28;56(8):753-64. Epub 2008 Apr 28.
Department of Pathology and Diagnostic Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene.
Mol Ther 2008 Jul 20;16(7):1227-34. Epub 2008 May 20.
Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.



The contribution of transcription factor IRF1 to the interferon-gamma-interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells.
Nat Immunol 2008 Jan 2;9(1):34-41. Epub 2007 Dec 2.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

Integration of HIV-1 caused STAT3-associated B cell lymphoma in an AIDS patient.
Microbes Infect 2007 Nov-Dec;9(14-15):1581-9. Epub 2007 Sep 14.
Department of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, Japan.



Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction.
J Exp Med 2006 Nov 6;203(12):2673-82. Epub 2006 Nov 6.
Department of Cell Signaling, Graduate School, and COE Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, Tokyo 113-8549, Japan.




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