Publications

Biallelic Mutations in KDSR Disrupt Ceramide Synthesis and Result in a Spectrum of Keratinization Disorders Associated with Thrombocytopenia.
J Invest Dermatol 2017 Nov 31;137(11):2344-2353. Epub 2017 Jul 31.
St. John's Institute of Dermatology, King's College London (Guy's Campus), London, UK; Centre for Dermatology and Genetic Medicine, Division of Molecular Medicine, University of Dundee, Dundee, UK. Electronic address:


Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis.
Bioorg Med Chem 2015 Aug 14;23(15):4434-41. Epub 2015 Jun 14.
Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:


Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.
J Med Chem 2011 Jun 26;54(12):4172-86. Epub 2011 May 26.
Université de Rennes 1, Sciences Chimiques de Rennes, UMR CNRS 6226, Groupe Ingénierie Chimique & Molécules pour le Vivant (ICMV), Bât. 10A, Campus de Beaulieu, Avenue du Général Leclerc, CS 74205, 35042 Rennes cedex, France.


Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.
Nat Commun 2010 Oct 5;1:86. Epub 2010 Oct 5.
Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.
J Biol Chem 2007 Sep 10;282(37):26687-95. Epub 2007 Jul 10.
Departments of Pathology and Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA.


Regulation of fibroblast growth factor-23 signaling by klotho.
J Biol Chem 2006 Mar 25;281(10):6120-3. Epub 2006 Jan 25.
Department of Pathology, Pediatrics, and Internal Medicine and Applied Genomics, Genzyme Corporation, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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