Publications

Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4.
Immunity 2018 Feb 27;48(2):286-298.e6. Epub 2018 Jan 27.
Laboratory of Immune Regulation, Department of Virus Research, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan. Electronic address:

Subtyping of Type 1 Diabetes as Classified by Anti-GAD Antibody, IgE Levels, and Tyrosine kinase 2 (TYK2) Promoter Variant in the Japanese.
EBioMedicine 2017 Sep 12;23:46-51. Epub 2017 Aug 12.
Department of Medical Science and Technology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, Japan; Department of Hepatology, Diabetes and Endocrinology, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga, Japan. Electronic address:

Interleukin-21 signaling in B cells, but not in T cells, is indispensable for the development of collagen-induced arthritis in mice.
Arthritis Res Ther 2016 Aug 17;18:188. Epub 2016 Aug 17.
Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.

IL-21/IL-21R signaling suppresses intestinal inflammation induced by DSS through regulation of Th responses in lamina propria in mice.
Sci Rep 2016 Aug 22;6:31881. Epub 2016 Aug 22.
Division of Host Defense, Center for Prevention of Infectious Disease, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.


An Enhancer of the IL-7 Receptor α-Chain Locus Controls IL-7 Receptor Expression and Maintenance of Peripheral T Cells.
J Immunol 2015 Oct 2;195(7):3129-38. Epub 2015 Sep 2.
Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan;

IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)Vγ6(+)γδ T cells.
Nat Commun 2015 Jun 25;6:7464. Epub 2015 Jun 25.
1] Laboratory of Molecular Pathogenesis, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan [2] Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0032, Japan [3] Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Saitama 332-0012, Japan [4] Division of Experimental Animal Immunology, Center for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba 278-0022, Japan.

Dermal Vγ4(+) γδ T cells possess a migratory potency to the draining lymph nodes and modulate CD8(+) T-cell activity through TNF-α production.
J Invest Dermatol 2015 Apr 10;135(4):1007-1015. Epub 2014 Dec 10.
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan. Electronic address:


Renal cancer treatment with recipient lymphocyte infusion enhanced the antitumor effect of nonmyeloablative allogeneic stem cell transplantation.
Transpl Immunol 2015 Mar 16;32(2):131-9. Epub 2014 Dec 16.
Division of Host Defense, Research Center for Prevention of Infectious Disease, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.


Oral administration of bovine milk from cows hyperimmunized with intestinal bacterin stimulates lamina propria T lymphocytes to produce Th1-biased cytokines in mice.
Int J Mol Sci 2014 Mar 28;15(4):5458-71. Epub 2014 Mar 28.
Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Identification of independent susceptible and protective HLA alleles in Japanese autoimmune thyroid disease and their epistasis.
J Clin Endocrinol Metab 2014 Feb 27;99(2):E379-83. Epub 2013 Nov 27.
Institute for Advanced Study (S.U., D.O., T.S.), Division of Genome Analysis (K.Y.), Medical Institute of Bioregulation, Department of Medicine and Clinical Science (K.O.), Graduate School of Medicine, and Division of Host Defense (H.Y., A.O., Y.Y.), Medical Institute of Bioregulation, Kyushu University, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan; Ito Hospital (J.Y.N., Y.K., K.S., K.I.), Shibuya-ku, Tokyo 150-8308, Japan; Department of Diabetes and Metabolic Medicine (M.N., K.I.), National Center for Global Health and Medicine, Shinjuku-ku, Tokyo 16-8655, Japan; Department of Laboratory (K.K.), Japanese Red Cross Tokyo Blood Center, Koto-ku, Tokyo 135-8639, Japan; and Department of Immunogenetics (Y.N.), Graduate School of Medical Sciences, Kumamoto University, Chuo-ku, Kumamoto 860-8556, Japan.

C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor.
Immunity 2013 May 18;38(5):1050-62. Epub 2013 Apr 18.
Division of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.

CD4 T cell-mediated masking effects of the immunogenicity of tumor-associated antigens are qualitatively and quantitatively different depending on the individual antigens.
Fukuoka Igaku Zasshi 2013 Jan;104(1):1-14
Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

Fas-deficient fully allogeneic dendritic cells administered via an intratumoral injection route show efficient antitumor effects in murine models.
Fukuoka Igaku Zasshi 2013 Jan;104(1):15-26
Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

A reduction of recipient regulatory T cells by cyclophosphamide contributes to an anti-tumor effect of nonmyeloablative allogeneic stem cell transplantation in mice.
Int J Cancer 2012 Jan 25;130(2):365-76. Epub 2011 Apr 25.
Division of Host Defense, Research Center for Prevention of Infectious Disease, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Kyushu, Japan.

Notch-Hes1 pathway is required for the development of IL-17-producing γδ T cells.
Blood 2011 Jul 23;118(3):586-93. Epub 2011 May 23.
Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, Higashi-ku, Fukuoka, Japan.

Functional involvement of dual specificity phosphatase 16 (DUSP16), a c-Jun N-terminal kinase-specific phosphatase, in the regulation of T helper cell differentiation.
J Biol Chem 2011 Jul 25;286(28):24896-905. Epub 2011 May 25.
Department of Oral Biochemistry, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.

Provision of continuous maturation signaling to dendritic cells by RIG-I-stimulating cytosolic RNA synthesis of Sendai virus.
J Immunol 2011 Feb 27;186(3):1828-39. Epub 2010 Dec 27.
Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.



Oral administration of heat-killed Lactobacillus plantarum L-137 enhances protection against influenza virus infection by stimulation of type I interferon production in mice.
Int Immunopharmacol 2009 Aug 3;9(9):1122-5. Epub 2009 May 3.
Research Center for Prevention of Infectious Diseases, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi-ku, Fukuoka, Japan.

Donor CD4 T cells are critical in allogeneic stem cell transplantation against murine solid tumor.
Cancer Res 2009 Jun 2;69(12):5151-8. Epub 2009 Jun 2.
Division of Host Defense, Research Center for Prevention of Infectious Disease, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

Allogeneic cell therapy from immunized donors with tumor antigen peptide enhances the antitumor effect after cyclophosphamide-using non-myeloablative allogeneic hematopoietic cell transplantation.
Cancer Sci 2009 Jan 24;100(1):138-43. Epub 2008 Nov 24.
Department of Urology, Graduate School of Medical Sciences, Kyushu University, and Center for Cellular and Molecular Medicine, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium.
J Immunol 2008 Dec;181(12):8521-7
Department of Microbiology and Immunology, Laboratory of Immune Regulation, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.




Regulatory roles of NKT cells in the induction and maintenance of cyclophosphamide-induced tolerance.
J Immunol 2006 Dec;177(12):8400-9
Department of Cardiovascular Surgery, Department of Pathology, Greaduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Critical roles of memory T cells and antidonor immunoglobulin in rejection of allogeneic bone marrow cells in sensitized recipient mice.
Transplantation 2006 Sep;82(5):689-98
Division of Pathophygiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

C-Type Lectin Receptor DCAR Recognizes Mycobacterial Phosphatidyl-Inositol Mannosides to Promote a Th1 Response during Infection.
Immunity 2016 12 22;45(6):1245-1257. Epub 2016 Nov 22.
Division of Molecular Immunology, Research Center for Infectious Diseases, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan; Division of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chiba 260-8673, Japan. Electronic address:


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