Publications by authors named "Yasuhiro Igarashi"

100Publications

Three new -isocrotonyl-3-hydroxybutyric acid congeners produced by a sea anemone-derived marine bacterium of the genus .

Beilstein J Org Chem 2020 29;16:1869-1874. Epub 2020 Jul 29.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.

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http://dx.doi.org/10.3762/bjoc.16.154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404252PMC
July 2020

Actinomadura decatromicini sp. nov., isolated from mountain soil in Thailand.

J Antibiot (Tokyo) 2020 Jul 28. Epub 2020 Jul 28.

Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.

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http://dx.doi.org/10.1038/s41429-020-0353-yDOI Listing
July 2020

4-Hydroxy-3-methyl-2(1)-quinolone, originally discovered from a plant, produced by a soil bacterium of the genus sp.: determination of a preferred tautomer and antioxidant activity.

Beilstein J Org Chem 2020 26;16:1489-1494. Epub 2020 Jun 26.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.

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http://dx.doi.org/10.3762/bjoc.16.124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323622PMC
June 2020

A cyclopeptide and three oligomycin-class polyketides produced by an underexplored actinomycete of the genus .

Beilstein J Org Chem 2020 25;16:1100-1110. Epub 2020 May 25.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.

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http://dx.doi.org/10.3762/bjoc.16.97DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277628PMC
May 2020

Draft genome sequence of sp. K4S16 and elucidation of the nonthmicin biosynthetic pathway.

J Genomics 2020 17;8:53-61. Epub 2020 May 17.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan.

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http://dx.doi.org/10.7150/jgen.44650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256010PMC
May 2020

Iseolides A-C, antifungal macrolides from a coral-derived actinomycete of the genus Streptomyces.

J Antibiot (Tokyo) 2020 Aug 11;73(8):534-541. Epub 2020 May 11.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, 939-0398, Japan.

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http://dx.doi.org/10.1038/s41429-020-0304-7DOI Listing
August 2020

Two antibacterial and PPARα/γ-agonistic unsaturated keto fatty acids from a coral-associated actinomycete of the genus .

Beilstein J Org Chem 2020 2;16:297-304. Epub 2020 Mar 2.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.

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http://dx.doi.org/10.3762/bjoc.16.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082699PMC
March 2020

Potent and broad anticancer activities of leaf extracts from L. of the subtropical Okinawa islands.

Am J Cancer Res 2020 1;10(2):581-594. Epub 2020 Feb 1.

Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University Onna, Okinawa 904-0495, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061759PMC
February 2020

Bulbimidazoles A-C, Antimicrobial and Cytotoxic Alkanoyl Imidazoles from a Marine Gammaproteobacterium Species.

J Nat Prod 2020 04 19;83(4):1295-1299. Epub 2020 Mar 19.

Biotechnology Research Center, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan.

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http://dx.doi.org/10.1021/acs.jnatprod.0c00082DOI Listing
April 2020

sp. nov. and Its Secondary Metabolite Biosynthetic Gene Clusters for Polyketide and Nonribosomal Peptide Compounds.

Microorganisms 2020 Mar 6;8(3). Epub 2020 Mar 6.

Biological Resource Center, National Institute of Technology and Evaluation (NBRC), 2-5-8 Kazusa-kamatari, Kisarazu, Chiba 292-0818, Japan.

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http://dx.doi.org/10.3390/microorganisms8030370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143880PMC
March 2020

Classification of '' Hamada and Yokoyama as sp. nov., the second species in the genus and emendation of the genus .

Int J Syst Evol Microbiol 2020 Mar;70(3):1591-1595

Biological Resource Center, National Institute of Technology and Evaluation (NBRC), Chiba 292-0818, Japan.

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http://dx.doi.org/10.1099/ijsem.0.003941DOI Listing
March 2020

Two new aromatic polyketides from a sponge-derived .

Beilstein J Org Chem 2019 9;15:2941-2947. Epub 2019 Dec 9.

Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.

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http://dx.doi.org/10.3762/bjoc.15.289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941419PMC
December 2019

Diversity of PKS and NRPS gene clusters between Streptomyces abyssomicinicus sp. nov. and its taxonomic neighbor.

J Antibiot (Tokyo) 2020 03 18;73(3):141-151. Epub 2019 Dec 18.

Biological Resource Center, National Institute of Technology and Evaluation (NBRC), 2-5-8 Kazusakamatari, Chiba, 292-0818, Japan.

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http://dx.doi.org/10.1038/s41429-019-0261-1DOI Listing
March 2020

Isolation and biosynthesis of an unsaturated fatty acid with unusual methylation pattern from a coral-associated bacterium sp.

Beilstein J Org Chem 2019 30;15:2327-2332. Epub 2019 Sep 30.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.

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http://dx.doi.org/10.3762/bjoc.15.225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6808205PMC
September 2019

Complete NMR assignment and absolute configuration of k4610422, a norditerpenoid inhibitor of testosterone-5α-reductase originally from Streptosporangium: rediscovery from a thermophilic Actinomadura.

J Antibiot (Tokyo) 2020 01 3;73(1):60-65. Epub 2019 Sep 3.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, 939-0398, Japan.

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http://dx.doi.org/10.1038/s41429-019-0231-7DOI Listing
January 2020

Konamycins A and B and Rubromycins CA1 and CA2, Aromatic Polyketides from the Tunicate-Derived Streptomyces hyaluromycini MB-PO13.

J Nat Prod 2019 06 7;82(6):1609-1615. Epub 2019 Jun 7.

Biotechnology Research Center and Department of Biotechnology , Toyama Prefectural University , 5180 Kurokawa , Imizu , Toyama 939-0398 , Japan.

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http://dx.doi.org/10.1021/acs.jnatprod.9b00107DOI Listing
June 2019

Ktedonoketone and 2'-oxosattabacin, benzenoid metabolites from a thermophilic bacterium Thermosporothrix hazakensis in the phylum Chloroflexi.

J Antibiot (Tokyo) 2019 09 5;72(9):653-660. Epub 2019 Jun 5.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, 939-0398, Japan.

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http://dx.doi.org/10.1038/s41429-019-0195-7DOI Listing
September 2019

Labrenzbactin from a coral-associated bacterium Labrenzia sp.

J Antibiot (Tokyo) 2019 08 22;72(8):634-639. Epub 2019 May 22.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, 939-0398, Japan.

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http://www.nature.com/articles/s41429-019-0192-x
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http://dx.doi.org/10.1038/s41429-019-0192-xDOI Listing
August 2019

Molecular Basis of Mannose Recognition by Pradimicins and their Application to Microbial Cell Surface Imaging.

Cell Chem Biol 2019 07 25;26(7):950-959.e8. Epub 2019 Apr 25.

Synthetic Cellular Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1016/j.chembiol.2019.03.013DOI Listing
July 2019

Tracing MYC Expression for Small Molecule Discovery.

Cell Chem Biol 2019 05 14;26(5):699-710.e6. Epub 2019 Mar 14.

Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada; The Rosalind and Morris Goodman Cancer Research Center and the Department of Oncology, McGill University, Montreal, QC, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456193004
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http://dx.doi.org/10.1016/j.chembiol.2019.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525070PMC
May 2019

Akazamicin, a cytotoxic aromatic polyketide from marine-derived Nonomuraea sp.

J Antibiot (Tokyo) 2019 04 10;72(4):202-209. Epub 2019 Jan 10.

Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7, Konan, Minato-ku, Tokyo, 108-8477, Japan.

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http://dx.doi.org/10.1038/s41429-018-0139-7DOI Listing
April 2019

Effects of surgical treatment for acromegaly on knee MRI structural features.

Endocr J 2018 Oct 13;65(10):991-999. Epub 2018 Jul 13.

Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Hospital, Sendai, Japan.

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http://dx.doi.org/10.1507/endocrj.EJ18-0108DOI Listing
October 2018

Two new 2-alkylquinolones, inhibitory to the fish skin ulcer pathogen , produced by a rhizobacterium of the genus sp.

Beilstein J Org Chem 2018 14;14:1446-1451. Epub 2018 Jun 14.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.

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http://dx.doi.org/10.3762/bjoc.14.122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009182PMC
June 2018

Cystargamide B, a cyclic lipodepsipeptide with protease inhibitory activity from Streptomyces sp.

J Antibiot (Tokyo) 2018 07 22;71(7):662-666. Epub 2018 Mar 22.

International Center for Biotechnology, Osaka University, Osaka, Japan.

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http://dx.doi.org/10.1038/s41429-018-0044-0DOI Listing
July 2018

Two new secondary metabolites from a fungus of the genus Robillarda.

J Antibiot (Tokyo) 2018 03 5;71(4):432-437. Epub 2018 Feb 5.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, 939-0398, Japan.

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http://dx.doi.org/10.1038/s41429-017-0015-xDOI Listing
March 2018

Draft genome sequence of MB-PO13, a hyaluromycin producer.

Stand Genomic Sci 2018 11;13. Epub 2018 Jan 11.

1Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

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http://dx.doi.org/10.1186/s40793-017-0286-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765640PMC
January 2018

GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection.

Nat Commun 2017 11 14;8(1):1485. Epub 2017 Nov 14.

State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.

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http://dx.doi.org/10.1038/s41467-017-01508-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684135PMC
November 2017

Quinocidin, a Cytotoxic Antibiotic with an Unusual 3,4-Dihydroquinolizinium Ring and Michael Acceptor Reactivity toward Thiols.

Chemistry 2017 Dec 30;23(71):17894-17897. Epub 2017 Nov 30.

Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan.

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http://dx.doi.org/10.1002/chem.201704729DOI Listing
December 2017

The Optimization of the Prevascularization Procedures for Improving Subcutaneous Islet Engraftment.

Transplantation 2018 03;102(3):387-395

Division of Advanced Surgical Science and Technology, Tohoku University School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1097/TP.0000000000001970DOI Listing
March 2018

Rakicidin F, a new antibacterial cyclic depsipeptide from a marine sponge-derived Streptomyces sp.

J Antibiot (Tokyo) 2017 Aug 2. Epub 2017 Aug 2.

International Center for Biotechnology, Osaka University, Osaka, Japan.

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http://dx.doi.org/10.1038/ja.2017.92DOI Listing
August 2017

Biosynthetic origin of butyrolactol A, an antifungal polyketide produced by a marine-derived .

Beilstein J Org Chem 2017 8;13:441-450. Epub 2017 Mar 8.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.

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http://www.beilstein-journals.org/bjoc/content/13/1/47
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http://dx.doi.org/10.3762/bjoc.13.47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355916PMC
March 2017

Two new sacrolide-class oxylipins from the edible cyanobacterium Aphanothece sacrum.

J Antibiot (Tokyo) 2017 05 8;70(5):708-709. Epub 2017 Mar 8.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

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http://dx.doi.org/10.1038/ja.2017.32DOI Listing
May 2017

Antarlides F-H, new members of the antarlide family produced by Streptomyces sp. BB47.

J Antibiot (Tokyo) 2017 May 8;70(5):595-600. Epub 2017 Feb 8.

Department of Bioscience and Informatics, Faculty of Science and Technology, Keio University, Kanagawa, Japan.

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http://dx.doi.org/10.1038/ja.2017.6DOI Listing
May 2017

Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade.

Proc Natl Acad Sci U S A 2017 02 30;114(7):1554-1559. Epub 2017 Jan 30.

State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China;

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http://dx.doi.org/10.1073/pnas.1610097114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321016PMC
February 2017

Hyaluromycin, a Novel Hyaluronidase Inhibitor, Attenuates Pancreatic Cancer Cell Migration and Proliferation.

J Oncol 2016 20;2016:9063087. Epub 2016 Dec 20.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

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http://dx.doi.org/10.1155/2016/9063087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206452PMC
December 2016

Simamycin (5'-O-geranyluridine): a new prenylated nucleoside from Streptomyces sp.

J Antibiot (Tokyo) 2017 May 18;70(5):607-610. Epub 2017 Jan 18.

Department of Nutritional Biochemistry, School of Nutrition and Dietetics, Kanagawa University of Human Services, Kanagawa, Japan.

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http://dx.doi.org/10.1038/ja.2016.163DOI Listing
May 2017

Draft Genome Sequence of an Anicemycin Producer, Streptomyces sp. TP-A0648.

Genome Announc 2017 Jan 12;5(2). Epub 2017 Jan 12.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

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http://dx.doi.org/10.1128/genomeA.01468-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256202PMC
January 2017

Proteomic profiling reveals that collismycin A is an iron chelator.

Sci Rep 2016 12 6;6:38385. Epub 2016 Dec 6.

Chemical Biology Research Group, RIKEN CSRS, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1038/srep38385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138588PMC
December 2016

Draft genome sequence of sp. TP-A0867, an alchivemycin producer.

Stand Genomic Sci 2016 24;11:85. Epub 2016 Oct 24.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

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http://dx.doi.org/10.1186/s40793-016-0207-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078962PMC
October 2016

Draft Genome Sequence of Streptomyces sp. TP-A0874, a Catechoserine Producer.

Genome Announc 2016 Oct 20;4(5). Epub 2016 Oct 20.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

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http://dx.doi.org/10.1128/genomeA.01163-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073265PMC
October 2016

Draft genome sequence of sp. MWW064 for elucidating the rakicidin biosynthetic pathway.

Stand Genomic Sci 2016 21;11:83. Epub 2016 Oct 21.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

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http://dx.doi.org/10.1186/s40793-016-0205-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073741PMC
October 2016

Inhibition of protein SUMOylation by natural quinones.

J Antibiot (Tokyo) 2016 10 9;69(10):776-779. Epub 2016 Mar 9.

Chemical Genetics Laboratory, RIKEN, Saitama, Japan.

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http://dx.doi.org/10.1038/ja.2016.23DOI Listing
October 2016

Draft Genome Sequence of Marine-Derived Bacillus subtilis TP-B0611, a Producer of Bacilosarcins and Amicoumacins.

Genome Announc 2016 Oct 13;4(5). Epub 2016 Oct 13.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

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http://dx.doi.org/10.1128/genomeA.01134-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064115PMC
October 2016

Draft Genome Sequence of Streptomyces sp. SPMA113, a Prajinamide Producer.

Genome Announc 2016 Oct 13;4(5). Epub 2016 Oct 13.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

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http://dx.doi.org/10.1128/genomeA.01126-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064113PMC
October 2016

Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models.

PLoS Pathog 2016 Sep 23;12(9):e1005851. Epub 2016 Sep 23.

Instituto de Parasitología y Biomedicina "López-Neyra", Consejo Superior de Investigaciones Científicas, Parque Tecnológico de Ciencias de la Salud, Armilla (Granada), Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035034PMC
http://dx.doi.org/10.1371/journal.ppat.1005851DOI Listing
September 2016

Complete Stereochemical Assignment of Campechic Acids A and B.

J Org Chem 2016 05 14;81(9):3638-47. Epub 2016 Apr 14.

Graduate School of Life Sciences, Tohoku University , 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.

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http://dx.doi.org/10.1021/acs.joc.6b00290DOI Listing
May 2016

Ulbactins F and G, Polycyclic Thiazoline Derivatives with Tumor Cell Migration Inhibitory Activity from Brevibacillus sp.

Org Lett 2016 Apr 21;18(7):1658-61. Epub 2016 Mar 21.

Bioscience and Informatics, Keio University , Yokohama, Kanagawa 223-8522, Japan.

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http://dx.doi.org/10.1021/acs.orglett.6b00531DOI Listing
April 2016

Antarlides: A New Type of Androgen Receptor (AR) Antagonist that Overcomes Resistance to AR-Targeted Therapy.

Angew Chem Int Ed Engl 2016 Feb 25;55(8):2728-32. Epub 2016 Jan 25.

Bioscience and Informatics, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan.

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http://dx.doi.org/10.1002/anie.201510079DOI Listing
February 2016

Draft Genome Sequence of Linfuranone Producer Microbispora sp. GMKU 363.

Genome Announc 2015 Dec 10;3(6). Epub 2015 Dec 10.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

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http://dx.doi.org/10.1128/genomeA.01471-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675959PMC
December 2015

Draft Genome Sequence of Streptomyces sp. TP-A0356, a Producer of Yatakemycin.

Genome Announc 2015 Dec 10;3(6). Epub 2015 Dec 10.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

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http://dx.doi.org/10.1128/genomeA.01446-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675949PMC
December 2015

Draft Genome Sequence of Nonomuraea sp. TP-A0861, a Producer of Myxochelin A.

Genome Announc 2015 Dec 10;3(6). Epub 2015 Dec 10.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

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http://genomea.asm.org/lookup/doi/10.1128/genomeA.01430-15
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http://dx.doi.org/10.1128/genomeA.01430-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675942PMC
December 2015

Draft Genome Sequence of Streptomyces sp. TP-A0871, a Producer of Heronamide C.

Genome Announc 2015 Dec 10;3(6). Epub 2015 Dec 10.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

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http://dx.doi.org/10.1128/genomeA.01429-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675941PMC
December 2015

Insights into the Biosynthesis of Dehydroalanines in Goadsporin.

Chembiochem 2016 Feb 8;17(3):218-23. Epub 2016 Jan 8.

Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan.

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http://dx.doi.org/10.1002/cbic.201500541DOI Listing
February 2016

Biosynthetic origin of anthracimycin: a tricyclic macrolide from Streptomyces sp.

J Antibiot (Tokyo) 2016 05 2;69(5):403-5. Epub 2015 Dec 2.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

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http://dx.doi.org/10.1038/ja.2015.118DOI Listing
May 2016

Arthroamide, a Cyclic Depsipeptide with Quorum Sensing Inhibitory Activity from Arthrobacter sp.

J Nat Prod 2015 Nov 17;78(11):2827-31. Epub 2015 Nov 17.

Departmento de Microbiologia y Genetica, Edificio Departamental Lab. 214, Universidad de Salamanca , Campus Miguel de Unamuno, 37007 Salamanca, Spain.

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http://dx.doi.org/10.1021/acs.jnatprod.5b00540DOI Listing
November 2015

Streptomyces hyaluromycini sp. nov., isolated from a tunicate (Molgula manhattensis).

J Antibiot (Tokyo) 2016 Mar 4;69(3):159-63. Epub 2015 Nov 4.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Kurokawa, Imizu, Toyama, Japan.

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http://dx.doi.org/10.1038/ja.2015.110DOI Listing
March 2016

The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.

Nature 2015 Nov 28;527(7577):254-8. Epub 2015 Oct 28.

Department of Biological Sciences and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1038/nature15728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896645PMC
November 2015

Characterization of the biosynthetic gene cluster for maklamicin, a spirotetronate-class antibiotic of the endophytic Micromonospora sp. NBRC 110955.

Microbiol Res 2015 Nov 22;180:30-9. Epub 2015 Jul 22.

International Center for Biotechnology, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan; MU-OU Collaborative Research Center for Bioscience and Biotechnology, Faculty of Science, Mahidol University, Rama VI Rd., Bangkok 10400, Thailand. Electronic address:

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http://dx.doi.org/10.1016/j.micres.2015.07.003DOI Listing
November 2015

Bacterial community structures of deep-sea water investigated by molecular biological techniques.

Gene 2016 Feb 22;576(2 Pt 1):696-700. Epub 2015 Oct 22.

Graduate School of Marine Science of Technology, Tokyo University of Marine Science and Technology, 4-5-7, Konan, Minato-ku, Tokyo 108-8477, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2015.10.027DOI Listing
February 2016

Draft Genome Sequence of Streptomyces sp. TP-A0890, a Producer of FR-900452 and A-74863a.

Genome Announc 2015 Oct 15;3(5). Epub 2015 Oct 15.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

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http://dx.doi.org/10.1128/genomeA.01212-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611700PMC
October 2015

Draft Genome Sequence of an Anthracimycin Producer, Streptomyces sp. TP-A0875.

Genome Announc 2015 Oct 8;3(5). Epub 2015 Oct 8.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

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http://dx.doi.org/10.1128/genomeA.01149-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599085PMC
October 2015

Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a producer of anti-MRSA antibiotic lydicamycins.

Stand Genomic Sci 2015 26;10:58. Epub 2015 Aug 26.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

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http://dx.doi.org/10.1186/s40793-015-0046-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572681PMC
September 2015

Draft genome sequence of Streptomyces sp. TP-A0882 reveals putative butyrolactol biosynthetic pathway.

FEMS Microbiol Lett 2015 Oct 3;362(20). Epub 2015 Sep 3.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama 939-0398, Japan.

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http://dx.doi.org/10.1093/femsle/fnv155DOI Listing
October 2015

Absolute configuration of NFAT-133, an aromatic polyketide with immunosuppressive and antidiabetic activity from actinomycetes.

J Antibiot (Tokyo) 2016 Jan 19;69(1):69-71. Epub 2015 Aug 19.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

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http://dx.doi.org/10.1038/ja.2015.80DOI Listing
January 2016

Cyclodepsipeptides produced by actinomycetes inhibit cyclic-peptide-mediated quorum sensing in Gram-positive bacteria.

FEMS Microbiol Lett 2015 Jul 5;362(14). Epub 2015 Jul 5.

Laboratory of Microbial Technology, Division of Applied Molecular Microbiology and Biomass Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan

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http://dx.doi.org/10.1093/femsle/fnv109DOI Listing
July 2015

Pradimicin A, a D-mannose-binding antibiotic, binds pyranosides of L-fucose and L-galactose in a calcium-sensitive manner.

Bioorg Med Chem Lett 2015 Aug 16;25(15):2963-6. Epub 2015 May 16.

Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2015.05.021DOI Listing
August 2015

Avellanin C, an inhibitor of quorum-sensing signaling in Staphylococcus aureus, from Hamigera ingelheimensis.

J Antibiot (Tokyo) 2015 Nov 6;68(11):707-10. Epub 2015 May 6.

US Department of Agriculture, National Center for Agricultural Utilization Research, Peoria, IL, USA.

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http://dx.doi.org/10.1038/ja.2015.50DOI Listing
November 2015

29-Deoxymaklamicin, a new maklamicin analogue produced by a genetically engineered strain of Micromonospora sp. NBRC 110955.

J Biosci Bioeng 2015 Dec 1;120(6):608-13. Epub 2015 May 1.

International Center for Biotechnology, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan; MU-OU Collaborative Research Center for Bioscience and Biotechnology, Faculty of Science, Mahidol University, Rama VI Rd., Bangkok 10400, Thailand. Electronic address:

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http://dx.doi.org/10.1016/j.jbiosc.2015.04.004DOI Listing
December 2015

Hikiamides A-C, Cyclic Pentadepsipeptides from Fusarium sp. TAMA 456.

J Nat Prod 2015 Apr 14;78(4):797-802. Epub 2015 Apr 14.

†Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.

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http://dx.doi.org/10.1021/np501047aDOI Listing
April 2015

Synergistic Effect of Neutral Protease and Clostripain on Rat Pancreatic Islet Isolation.

Transplantation 2015 Jul;99(7):1349-55

1Division of Advanced Surgical Science and Technology, Tohoku University School of Medicine, Sendai, Japan. 2New Industry Creation Hatchery Center, Tohoku University, Sendai, Japan. 3Graduate school of Agricultural Science, Tokyo University of Agriculture and Technology, Tokyo, Japan. 4Graduate school of Biomedical Engineering, Tohoku University, Sendai, Japan. 5Department of Integrative Genomics, Tohoku Medical Megabank Organization (ToMMO), Tohoku University School of Medicine, Sendai, Japan. 6Department of Biochemistry, Center for Regulatory Epigenome and Diseases, Tohoku University Graduated School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1097/TP.0000000000000662DOI Listing
July 2015

Draft Genome Sequence of Marine-Derived Streptomyces sp. TP-A0873, a Producer of a Pyrrolizidine Alkaloid Bohemamine.

Genome Announc 2015 Feb 19;3(1). Epub 2015 Feb 19.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

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http://genomea.asm.org/lookup/doi/10.1128/genomeA.00008-15
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http://dx.doi.org/10.1128/genomeA.00008-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335319PMC
February 2015

Tolypoalbin, a new tetramic acid from Tolypocladium album TAMA 479.

J Antibiot (Tokyo) 2015 Jun 28;68(6):399-402. Epub 2015 Jan 28.

Department of Biotechnology, Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan.

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http://dx.doi.org/10.1038/ja.2014.165DOI Listing
June 2015

Biosynthesis of akaeolide and lorneic acids and annotation of type I polyketide synthase gene clusters in the genome of Streptomyces sp. NPS554.

Mar Drugs 2015 Jan 16;13(1):581-96. Epub 2015 Jan 16.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.

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http://dx.doi.org/10.3390/md13010581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306953PMC
January 2015

Two butenolides with PPARα agonistic activity from a marine-derived Streptomyces.

J Antibiot (Tokyo) 2015 May 12;68(5):345-7. Epub 2014 Nov 12.

Department of Life Science, Faculty of Science, Okayama University of Science, Okayama, Japan.

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http://dx.doi.org/10.1038/ja.2014.151DOI Listing
May 2015

Species-level assessment of secondary metabolite diversity among species and a taxonomic note on the genus.

Mycology 2014 Jul 27;5(3):102-109. Epub 2014 May 27.

Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston , 1881 East Road, Houston , TX 77054 , USA.

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http://dx.doi.org/10.1080/21501203.2014.917736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205921PMC
July 2014

Complete stereochemistry and preliminary structure-activity relationship of rakicidin A, a hypoxia-selective cytotoxin from Micromonospora sp.

J Nat Prod 2014 Nov 6;77(11):2561-5. Epub 2014 Nov 6.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University , 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.

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http://dx.doi.org/10.1021/np500276cDOI Listing
November 2014

A modified recombineering protocol for the genetic manipulation of gene clusters in Aspergillus fumigatus.

PLoS One 2014 5;9(11):e111875. Epub 2014 Nov 5.

Manchester Fungal Infection Group, Institute for Inflammation and Repair, Faculty of Medicine and Human Sciences, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111875PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221250PMC
July 2015

Identification of the n-1 fatty acid as an antibacterial constituent from the edible freshwater cyanobacterium Nostoc verrucosum.

Biosci Biotechnol Biochem 2014 17;78(7):1147-50. Epub 2014 Jun 17.

a Biotechnology Research Center and Department of Biotechnology , Toyama Prefectural University , Toyama , Japan.

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http://dx.doi.org/10.1080/09168451.2014.918484DOI Listing
June 2015

Sacrolide A, a new antimicrobial and cytotoxic oxylipin macrolide from the edible cyanobacterium Aphanothece sacrum.

Beilstein J Org Chem 2014 7;10:1808-16. Epub 2014 Aug 7.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.

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http://dx.doi.org/10.3762/bjoc.10.190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142850PMC
August 2014

Genetic approaches to generate hyper-producing strains of goadsporin: the relationships between productivity and gene duplication in secondary metabolite biosynthesis.

Biosci Biotechnol Biochem 2014 16;78(3):394-9. Epub 2014 Apr 16.

a Department of Biotechnology , Toyama Prefectural University , Imizu, Toyama , Japan.

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http://dx.doi.org/10.1080/09168451.2014.885824DOI Listing
April 2015

Draft Genome Sequence of Marine-Derived Actinomycete Nocardiopsis sp. Strain TP-A0876, a Producer of Polyketide Pyrones.

Genome Announc 2014 Jul 10;2(4). Epub 2014 Jul 10.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

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http://dx.doi.org/10.1128/genomeA.00665-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110758PMC
July 2014

Nocapyrones: α- and γ-pyrones from a marine-derived Nocardiopsis sp.

Mar Drugs 2014 Jul 8;12(7):4110-25. Epub 2014 Jul 8.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.

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http://dx.doi.org/10.3390/md12074110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113818PMC
July 2014

Genome mining reveals a minimum gene set for the biosynthesis of 32-membered macrocyclic thiopeptides lactazoles.

Chem Biol 2014 May 24;21(5):679-88. Epub 2014 Apr 24.

Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan; Biotechnology Research Center, Toyama Prefectural University, Imizu 939-0398, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2014.03.008DOI Listing
May 2014

Cyclic lipodepsipeptides verlamelin A and B, isolated from entomopathogenic fungus Lecanicillium sp.

J Antibiot (Tokyo) 2014 Jun 2;67(6):459-63. Epub 2014 Apr 2.

1] International Center for Biotechnology, Osaka University, Osaka, Japan [2] Mahidol University-Osaka University Collaborative Research Center for Bioscience and Biotechnology, Faculty of Science, Mahidol University, Bangkok, Thailand.

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http://dx.doi.org/10.1038/ja.2014.22DOI Listing
June 2014

Campechic acids A and B: anti-invasive polyether polyketides from a soil-derived Streptomyces.

J Nat Prod 2014 Apr 4;77(4):976-82. Epub 2014 Mar 4.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University , 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.

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http://dx.doi.org/10.1021/np401071xDOI Listing
April 2014

Isolation and biosynthesis of preussin B, a pyrrolidine alkaloid from Simplicillium lanosoniveum.

J Nat Prod 2014 Apr 4;77(4):813-7. Epub 2014 Mar 4.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University , 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.

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http://dx.doi.org/10.1021/np400910rDOI Listing
April 2014

Two new ring-contracted congeners of rhizopodin illustrate significance of the ring moiety of macrolide toxins on the actin disassembly-mediated cytotoxicity.

Chem Pharm Bull (Tokyo) 2014 ;62(3):294-300

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University.

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http://dx.doi.org/10.1248/cpb.c13-00856DOI Listing
January 2015