Yardena Samuels

Yardena Samuels

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Yardena Samuels

Publications by authors named "Yardena Samuels"

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Exome Sequencing of ABCB5 Identifies Recurrent Melanoma Mutations that Result in Increased Proliferative and Invasive Capacities.

J Invest Dermatol 2019 Sep 21;139(9):1985-1992.e10. Epub 2019 Mar 21.

Laboratory of Molecular Cancer Biology, Molecular Physiology Research Unit (URPHYM), Namur Research Institute for Life Sciences, Faculty of Medicine, Department of Biomedical Sciences, University of Namur, Namur, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193133
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http://dx.doi.org/10.1016/j.jid.2019.01.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708748PMC
September 2019

A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma.

Pigment Cell Melanoma Res 2019 Sep 24. Epub 2019 Sep 24.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1111/pcmr.12825DOI Listing
September 2019

Cancer Exome-Based Identification of Tumor Neo-Antigens Using Mass Spectrometry.

Methods Mol Biol 2019 ;1884:203-214

Molecular Cell Biology Department, Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1007/978-1-4939-8885-3_14DOI Listing
June 2019

Cross-Talk between Receptor Tyrosine Kinases AXL and ERBB3 Regulates Invadopodia Formation in Melanoma Cells.

Cancer Res 2019 May 26;79(10):2634-2648. Epub 2019 Mar 26.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-2316DOI Listing
May 2019

RASA2 and NF1; two-negative regulators of Ras with complementary functions in melanoma.

Oncogene 2019 03 26;38(13):2432-2434. Epub 2018 Nov 26.

Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1038/s41388-018-0578-4DOI Listing
March 2019

PIK3CA in cancer: The past 30 years.

Semin Cancer Biol 2019 Feb 10. Epub 2019 Feb 10.

Weizmann Institute of Science, Rehovot, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2019.02.002DOI Listing
February 2019

Analysis of Enzymatic Activity of Matrix Metalloproteinase (MMP) by Collagen Zymography in Melanoma.

Methods Mol Biol 2018 ;1731:97-106

Molecular Cell Biology Department, Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1007/978-1-4939-7595-2_10DOI Listing
January 2019

Cancer research in the era of immunogenomics.

ESMO Open 2018 26;3(7):e000475. Epub 2018 Dec 26.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

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http://esmoopen.bmj.com/lookup/doi/10.1136/esmoopen-2018-000
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http://dx.doi.org/10.1136/esmoopen-2018-000475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307593PMC
December 2018

Mutated MITF-E87R in Melanoma Enhances Tumor Progression via S100A4.

J Invest Dermatol 2018 10 19;138(10):2216-2223. Epub 2018 Apr 19.

INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, Ecole Pratique des Hautes Etudes, Paris Sciences-Lettres, Faculté de médecine-Université Paris-Sud, Université Paris-Saclay, 94805, Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.03.1524DOI Listing
October 2018

Refinement of the endogenous epitope tagging technology allows the identification of a novel NRAS binding partner in melanoma.

Pigment Cell Melanoma Res 2018 09 16;31(5):641-648. Epub 2018 May 16.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1111/pcmr.12705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438458PMC
September 2018

Genetic and Functional Analysis of GRIN2A in Tumor Samples.

Methods Mol Biol 2017 ;1677:93-116

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel.

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http://dx.doi.org/10.1007/978-1-4939-7321-7_3DOI Listing
June 2018

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.

Cancer Cell 2018 02;33(2):322-336.e8

Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Medical Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, 13353 Berlin, Germany; Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner Site Berlin, Germany.

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http://dx.doi.org/10.1016/j.ccell.2018.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977991PMC
February 2018

Synonymous Somatic Variants in Human Cancer Are Not Infamous: A Plea for Full Disclosure in Databases and Publications.

Hum Mutat 2017 04 2;38(4):339-342. Epub 2017 Feb 2.

Molecular Cell Biology Department, Weizmann Institute of Science, Rehovot, 76100, Israel.

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http://dx.doi.org/10.1002/humu.23163DOI Listing
April 2017

Parkinson disease (PARK) genes are somatically mutated in cutaneous melanoma.

Neurol Genet 2016 Jun 13;2(3):e70. Epub 2016 Apr 13.

Department of Neurology (R.I.), Department of Dermatology (E.A.), Sackler Faculty of Medicine, Tel Aviv University; Center of Advanced Technologies in Rehabilitation (R.I.), Sheba Medical Center, Tel Hashomer; Department of Molecular Cell Biology (Y.S., N.Q.), Weizmann Institute of Science, Rehovot; The Sagol School of Neuroscience (L.I.), Tel Aviv University; Department of Physics of Complex Systems (E.D.), Weizmann Institute of Science, Rehovot; Department of Industrial Engineering and Management (E.S.), Ben Gurion University of the Negev, Beer Sheva; The Susanne Levy Gertner Oncogenetics Unit (E.F.), Institute of Human Genetics, Sheba Medical Center, Tel-Hashomer; and the Sackler Faculty of Medicine (E.F.), Tel Aviv University, Israel.

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http://ng.neurology.org/lookup/doi/10.1212/NXG.0000000000000
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http://dx.doi.org/10.1212/NXG.0000000000000070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832432PMC
June 2016

Parkin Somatic Mutations Link Melanoma and Parkinson's Disease.

J Genet Genomics 2016 06 13;43(6):369-79. Epub 2016 May 13.

Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2016.05.005DOI Listing
June 2016

The involvement of mutant Rac1 in the formation of invadopodia in cultured melanoma cells.

Exp Cell Res 2016 04 10;343(1):82-88. Epub 2016 Feb 10.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2016.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954600PMC
April 2016

The functional relevance of somatic synonymous mutations in melanoma and other cancers.

Pigment Cell Melanoma Res 2015 Nov;28(6):673-84

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1111/pcmr.12413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834044PMC
November 2015

YAP and the drug resistance highway.

Nat Genet 2015 Mar;47(3):193-4

Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1038/ng.3228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881807PMC
March 2015

Mutational and functional analysis of the tumor-suppressor PTPRD in human melanoma.

Hum Mutat 2014 Nov 10;35(11):1301-10. Epub 2014 Sep 10.

National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1002/humu.22630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394620PMC
November 2014

Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation.

J Invest Dermatol 2014 Sep 16;134(9):2390-2398. Epub 2014 Apr 16.

Cancer Genetics Branch, National Human Genetics Research Institute, National Institutes of Health, Bethesda, Maryland, USA; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X153695
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http://dx.doi.org/10.1038/jid.2014.190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134353PMC
September 2014

ERBB4 mutation analysis: emerging molecular target for melanoma treatment.

Methods Mol Biol 2014 ;1102:461-80

Clinical Genetics Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/978-1-62703-727-3_24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125540PMC
June 2014

The genetics of melanoma: recent advances.

Annu Rev Genomics Hum Genet 2013 12;14:257-79. Epub 2013 Jul 12.

Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892.

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http://dx.doi.org/10.1146/annurev-genom-091212-153429DOI Listing
December 2013

Shimmer: detection of genetic alterations in tumors using next-generation sequence data.

Bioinformatics 2013 Jun 24;29(12):1498-503. Epub 2013 Apr 24.

Genome Technology Branch, NHGRI/NIH, Bethesda, MD 20892-9400, USA.

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http://dx.doi.org/10.1093/bioinformatics/btt183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673219PMC
June 2013

Comparative exome sequencing of metastatic lesions provides insights into the mutational progression of melanoma.

BMC Genomics 2012 Sep 24;13:505. Epub 2012 Sep 24.

The Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1186/1471-2164-13-505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500261PMC
September 2012

Molecular pathways: dysregulated glutamatergic signaling pathways in cancer.

Clin Cancer Res 2012 Aug 30;18(16):4240-6. Epub 2012 May 30.

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-11-1217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421042PMC
August 2012

Delving into somatic variation in sporadic melanoma.

Pigment Cell Melanoma Res 2012 Mar 13;25(2):155-70. Epub 2012 Feb 13.

The Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

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http://doi.wiley.com/10.1111/j.1755-148X.2012.00976.x
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http://dx.doi.org/10.1111/j.1755-148X.2012.00976.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374856PMC
March 2012

Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma.

Hum Mutat 2011 Jun 24;32(6):E2148-75. Epub 2011 Feb 24.

Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA.

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http://doi.wiley.com/10.1002/humu.21477
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http://dx.doi.org/10.1002/humu.21477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103704PMC
June 2011

Exome sequencing identifies GRIN2A as frequently mutated in melanoma.

Nat Genet 2011 May 15;43(5):442-6. Epub 2011 Apr 15.

The Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/ng.810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161250PMC
May 2011

Oncogenic mutations of PIK3CA in human cancers.

Curr Top Microbiol Immunol 2010 ;347:21-41

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

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http://www.weizmann.ac.il/mcb/Samuels/sites/mcb.Samuels/file
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http://link.springer.com/10.1007/82_2010_68
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http://dx.doi.org/10.1007/82_2010_68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164550PMC
January 2011

Novel somatic mutations in heterotrimeric G proteins in melanoma.

Cancer Biol Ther 2010 Jul;10(1):33-7

Cancer Genetics Branch, National Institutes of Health (NIH); Bethesda, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040832PMC
http://dx.doi.org/10.4161/cbt.10.1.11949DOI Listing
July 2010

IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain.

Biochem Biophys Res Commun 2010 Jul 13;398(3):585-7. Epub 2010 Jul 13.

The Preston Robert Tisch Brain Tumor Center, The Pediatric Brain Tumor Foundation, and The Department of Pathology, Duke University Medical Center, DUMC 3156, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.bbrc.2010.06.125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987603PMC
July 2010

A growing family: adding mutated Erbb4 as a novel cancer target.

Cell Cycle 2010 Apr 15;9(8):1487-503. Epub 2010 Apr 15.

National Cancer Institute, Surgery Branch, Bethesda, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384517PMC
http://dx.doi.org/10.4161/cc.9.8.11239DOI Listing
April 2010

TYRO3-mediated regulation of MITF: a novel target in melanoma?

Pigment Cell Melanoma Res 2010 Feb 20;23(1):9-11. Epub 2009 Oct 20.

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http://dx.doi.org/10.1111/j.1755-148X.2009.00649.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159175PMC
February 2010

Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.

Proc Natl Acad Sci U S A 2010 Feb 20;107(6):2598-603. Epub 2010 Jan 20.

The Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1073/pnas.0914018107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823889PMC
February 2010

Protective roles of matrix metalloproteinases: from mouse models to human cancer.

Cell Cycle 2009 Nov 1;8(22):3657-62. Epub 2009 Dec 1.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164587PMC
http://dx.doi.org/10.4161/cc.8.22.9956DOI Listing
November 2009

Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.

Nat Genet 2009 Oct 30;41(10):1127-32. Epub 2009 Aug 30.

Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/ng.438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897709PMC
October 2009

Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma.

Cancer Res 2008 Dec;68(24):10300-6

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, District of Columbia 20057, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-3272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760967PMC
December 2008

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.

Science 2007 Dec;318(5857):1744-8

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1126/science.1150799DOI Listing
December 2007

Serial assessment of human tumor burdens in mice by the analysis of circulating DNA.

Cancer Res 2007 Oct;67(19):9364-70

The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0605DOI Listing
October 2007

iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53.

Nat Genet 2006 Oct 10;38(10):1133-41. Epub 2006 Sep 10.

Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London W1W 7BS, UK.

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http://dx.doi.org/10.1038/ng1879DOI Listing
October 2006

Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms.

Cancer Biol Ther 2006 Jul 26;5(7):779-85. Epub 2006 Jul 26.

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.4161/cbt.5.7.2751DOI Listing
July 2006

Oncogenic PI3K and its role in cancer.

Curr Opin Oncol 2006 Jan;18(1):77-82

The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1097/01.cco.0000198021.99347.b9DOI Listing
January 2006

Colorectal cancer: mutations in a signalling pathway.

Nature 2005 Aug;436(7052):792

The Sidney Kimmel Comprehensive Cancer Center and The Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1038/436792aDOI Listing
August 2005

Mutant PIK3CA promotes cell growth and invasion of human cancer cells.

Cancer Cell 2005 Jun;7(6):561-73

The Sidney Kimmel Comprehensive Cancer Center and The Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S153561080500160
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http://dx.doi.org/10.1016/j.ccr.2005.05.014DOI Listing
June 2005

Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation.

Oncogene 2005 May;24(23):3836-41

Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London W1W 7BS, UK.

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http://www.nature.com/articles/1208535
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http://dx.doi.org/10.1038/sj.onc.1208535DOI Listing
May 2005

Inhibiting phosphoinositide 3-kinases.

Cancer Biol Ther 2005 May 15;4(5):546-7. Epub 2005 May 15.

The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.4161/cbt.4.5.1669DOI Listing
May 2005

Oncogenic mutations of PIK3CA in human cancers.

Cell Cycle 2004 Oct 12;3(10):1221-4. Epub 2004 Oct 12.

The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.4161/cc.3.10.1164DOI Listing
October 2004

The PIK3CA gene is mutated with high frequency in human breast cancers.

Cancer Biol Ther 2004 Aug 26;3(8):772-5. Epub 2004 Aug 26.

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Department of Oncology, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.4161/cbt.3.8.994DOI Listing
August 2004

Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas.

Cancer Res 2004 Aug;64(15):5048-50

Brain Tumor Center, Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-1170DOI Listing
August 2004

High frequency of mutations of the PIK3CA gene in human cancers.

Science 2004 Apr 11;304(5670):554. Epub 2004 Mar 11.

Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1126/science.1096502DOI Listing
April 2004

ASPP1 and ASPP2: common activators of p53 family members.

Mol Cell Biol 2004 Feb;24(3):1341-50

Ludwig Institute for Cancer Research, Imperial College School of Medicine, St. Mary's Campus, London W2 1PG, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC321425PMC
http://dx.doi.org/10.1128/mcb.24.3.1341-1350.2004DOI Listing
February 2004

iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

Nat Genet 2003 Feb 13;33(2):162-7. Epub 2003 Jan 13.

Ludwig Institute for Cancer Research, Imperial College School of Medicine, St. Mary's Campus, Norfolk Place, London, W2 1PG, UK.

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http://dx.doi.org/10.1038/ng1070DOI Listing
February 2003