Publications by authors named "Yapeng Li"

87 Publications

Shear stress and ROS-responsive biomimetic micelles for atherosclerosis via ROS consumption.

Mater Sci Eng C Mater Biol Appl 2021 Jul 4;126:112164. Epub 2021 May 4.

Key Laboratory of Special Engineering Plastics Ministry of Education, College of Chemistry, Jilin University, Changchun 130012, China. Electronic address:

Reactive oxygen species (ROS) are well-known important initiating factors required for atherosclerosis formation, which leads to endothelial dysfunction and plaque formation. Most of the existing antithrombotic therapies use ROS-responsive drug delivery systems, which have a certain therapeutic effect but cannot eliminate excess ROS. Therefore, the atherosclerosis cannot be treated from the source. Moreover, nanoparticles are easily cleared by the immune system during blood circulation, which is not conducive to long-term circulation. In this study, we developed an intelligent response system that could simultaneously respond to ROS and the shear stress microenvironment of atherosclerotic plaques. This system was formed by red blood cells (RBCs) and simvastatin-loaded micelles (SV MC). The micelles consisted of poly(glycidyl methacrylate)-polypropylene sulfide (PGED-PPS). The hydrophobic PPS could react with excess ROS to become hydrophilic, which forced the micelle rupture, resulting in drug release. Most importantly, PPS could also significantly deplete the ROS level, realizing the synergistic treatment of atherosclerosis with drugs and materials. The positively charged SV MC and negatively charged RBCs were self-assembled through electrostatic adsorption to obtain SV [email protected] The SV [email protected] could respond to the high shear stress at the atherosclerotic plaque, and the shear stress induced SV MC desorption from the RBC surface. Using biomimetic methods to evade the SV [email protected] elimination by the immune system and to reduce the ROS plays a vital role in improving atherosclerosis treatment. The results of in vitro and in vivo experiments showed that SV [email protected] could effectively treat atherosclerosis. Moreover, not only does the SV [email protected] system avoid the risk of bleeding, but it also has excellent in vivo safety. The study results indicate that the SV [email protected] system is a promising therapeutic nanomedicine for treating ROS-related diseases.
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http://dx.doi.org/10.1016/j.msec.2021.112164DOI Listing
July 2021

Metabolically healthy obesity increases the prevalence of stroke in adults aged 40 years or older: Result from the China National Stroke Screening survey.

Prev Med 2021 07 18;148:106551. Epub 2021 Apr 18.

Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan Province, China. Electronic address:

Debate over the cardio-cerebrovascular risk associated with metabolically healthy obesity (MHO) continues. In this study we investigated the association of MHO with the risk of stroke among 221,114 individuals aged 40 years or older based on data from the China National Stroke Screening and Prevention Project (CNSSPP), a nationally representative cross-sectional study, during 2014 to 2015. Different metabolic health and obesity phenotypes were defined according to the Adult Treatment Panel III (ATP III) criteria, where obesity was defined as a body mass index (BMI) ≥28 kg/m. Logistic regression models were used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for stroke risk associated with different metabolically healthy phenotypes. BMI was used to estimate the mediation effect for metabolic abnormalities to stroke. Compared with the metabolically healthy non-obesity (MHNO) group, individuals with MHO (adjusted OR: 1.21, 95% CI: 1.10,1.33), metabolically unhealthy non-obesity (MUNO) (adjusted OR:1.41, 95% CI: 1.36,1.46), or metabolically unhealthy obesity (MUO) (adjusted OR: 1.70, 95% CI: 1.61,1.80) were found to have an increased risk of stroke. The findings were confirmed robustly by various sensitivity analyses and subgroup analyses. Furthermore, obesity and metabolic abnormalities had an additive interaction for stroke risk with an attributable proportion (AP) of 14.0% in females. BMI played a partial mediating role with the proportion of the effect (PE) at 11.1% in the relationship between metabolic abnormalities and stroke. This study strengthens the evidence that management and interventions in the MHO population may contribute to the primary prevention of stroke.
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http://dx.doi.org/10.1016/j.ypmed.2021.106551DOI Listing
July 2021

Superhydrophilic Ni-based Multicomponent Nanorod-Confined-Nanoflake Array Electrode Achieves Waste-Battery-Driven Hydrogen Evolution and Hydrazine Oxidation.

Small 2021 May 26;17(19):e2008148. Epub 2021 Mar 26.

Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Materials for Energy Conversion, Department of Materials Science and Engineering, University of Science and Technology of China, Hefei, 230026, China.

The low thermodynamic potential (-0.33 V) and safe by-product of N /H O, make utilizing hydrazine oxidation reaction (HzOR) to replace thermodynamically-unfavorable and kinetically-sluggish oxygen evolution reaction a promising tactic for energy-efficient hydrogen production. However, the complexity of bifunctionality increases difficulties for effective material design, thus hindering the large-scale hydrogen generation. Herein, we present the rationally designed synthesis of superhydrophilic Ni-based multicomponent arrays (Ni NCNAs) composed of 1D nanorod-confined-nanoflakes (2D), which only needs -26 mV of working potential and 47 mV of overpotential to reach 10 mA cm for HzOR and HER, respectively. Impressively, this Ni NCNA electrode exhibits the top-level bifunctional activity for overall hydrazine splitting (OHzS) with an ultralow voltage of 23 mV at 10 mA cm and a record-high current density of 892 mA cm at just 0.485 V, also achieves the high-speed hydrogen yield driven by a waste AAA battery for OHzS.
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http://dx.doi.org/10.1002/smll.202008148DOI Listing
May 2021

Dual-Functional Template-Induced Polymerization Process Enables the Hierarchical Carbonaceous Nanotubes with Simultaneous Sn Cluster Incorporation and Nitrogen-Doping for Superior Potassium-Ion Storage.

ACS Appl Mater Interfaces 2021 Mar 15;13(11):13139-13148. Epub 2021 Mar 15.

Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Materials for Energy Conversion, Department of Materials Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China.

Potassium ion-based energy storage devices have received extensive attention for grid-level applications due to their abundant natural resources and low cost. However, the large ionic radius of K leads to inferior capacities and cyclic stability, which hinders their practical application. Herein, hierarchical carbonaceous nanotubes with simultaneous ultrasmall Sn cluster incorporation and nitrogen doping (denoted as [email protected]) are fabricated using MnO nanowires as a dual-functional template ( polymerization and shape-directing agents) and subsequent carbonization treatment. The [email protected] exhibit a superior K storage capability with a high reversible capacity (220.1 mA h g at 0.1 A g) and long cycling stability (149.9 mA h g at 1 A g after 4000 cycles). Besides, the [email protected] exhibit superior cycling stability up to 10000 cycles at 5 A g for Na storage. The potassium storage mechanism and kinetics are investigated based on X-ray photoelectron spectroscopy, Raman spectrum, and galvanostatic intermittent titration technique. More importantly, [email protected] can be used as the anode for potassium ion hybrid capacitors, achieving a superior energy density of 181.4 W h kg at a power density of 185 W kg with excellent cycling capability. This work could push forward the development and application of carbonaceous-based anode materials for next-generation high-performance rechargeable batteries.
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http://dx.doi.org/10.1021/acsami.0c21883DOI Listing
March 2021

GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers.

Nat Commun 2021 01 21;12(1):494. Epub 2021 Jan 21.

Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, 80206, USA.

Mast cells are critical effectors of allergic inflammation and protection against parasitic infections. We previously demonstrated that transcription factors GATA2 and MITF are the mast cell lineage-determining factors. However, it is unclear whether these lineage-determining factors regulate chromatin accessibility at mast cell enhancer regions. In this study, we demonstrate that GATA2 promotes chromatin accessibility at the super-enhancers of mast cell identity genes and primes both typical and super-enhancers at genes that respond to antigenic stimulation. We find that the number and densities of GATA2- but not MITF-bound sites at the super-enhancers are several folds higher than that at the typical enhancers. Our studies reveal that GATA2 promotes robust gene transcription to maintain mast cell identity and respond to antigenic stimulation by binding to super-enhancer regions with dense GATA2 binding sites available at key mast cell genes.
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http://dx.doi.org/10.1038/s41467-020-20766-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820599PMC
January 2021

Vanadium Substitution Steering Reaction Kinetics Acceleration for NiN Nanosheets Endows Exceptionally Energy-Saving Hydrogen Evolution Coupled with Hydrazine Oxidation.

ACS Appl Mater Interfaces 2021 Jan 19;13(3):3881-3890. Epub 2021 Jan 19.

Hefei National Laboratory for Physical Sciences at the Microscale, Key Laboratory of Materials for Energy Conversion, Department of Materials Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China.

Designing highly active transition-metal-based electrocatalysts for energy-saving electrochemical hydrogen evolution coupled with hydrazine oxidation possesses more economic prospects. However, the lack of bifunctional electrocatalysts and the absence of intrinsic structure-property relationship research consisting of adsorption configurations and dehydrogenation behavior of NH molecules still hinder the development. Now, a V-doped NiN nanosheet self-supported on Ni foam (V-NiN NS) is reported, which presents excellent bifunctional electrocatalytic performance toward both hydrazine oxidation reaction (HzOR) and hydrogen evolution reaction (HER). The resultant V-NiN NS achieves an ultralow working potential of 2 mV and a small overpotential of 70 mV at 10 mA cm in alkaline solution for HzOR and HER, respectively. Density functional theory calculations reveal that the vanadium substitution could effectively modulate the electronic structure of NiN, therefore facilitating the adsorption/desorption behavior of H* for HER, as well as boosting the dehydrogenation kinetics for HzOR.
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http://dx.doi.org/10.1021/acsami.0c18684DOI Listing
January 2021

Phosphorus-doping-induced kinetics modulation for nitrogen-doped carbon mesoporous nanotubes as superior alkali metal anode beyond lithium for high-energy potassium-ion hybrid capacitors.

Nanoscale 2021 Jan 23;13(2):692-699. Epub 2020 Dec 23.

Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Materials for Energy Conversion, Department of Materials Science and Engineering, University of Science and Technology of China, Hefei 230026, China.

Alkali metal ion beyond lithium based energy storage systems have recently attracted increasing attention due to their unique advantages of high natural abundance and low cost. Herein, we report the fabrication of P,N-codoped carbon mesoporous nanotubes (denoted as PNC-MeNTs) through a facile two-step strategy with MnO nanowires as a dual-function sacrificing template, where the in situ oxidative polymerization formation of pyrrole-aniline-phytic acid composite nanotubes and a subsequent carbonization treatment are involved. The PNC-MeNTs exhibit outstanding electrochemical performance for both Na and K storage, respectively, where high specific capacities of 287.2 mA h g and 219.6 mA h g at 0.1 A g and remarkable cycling stability over 10 000 cycles at 10 A g and 3000 cycles at 1 A g can be achieved. More importantly, potassium-ion hybrid capacitors with a PNC-MeNT anode and an activated carbon cathode can deliver remarkable energy/power density of 175.1 W h kg/160.6 W kg, as well as a long cycling life. The possible origins and storage mechanisms are investigated with combined characterization methods including in situ Raman spectroscopy and a galvanostatic intermittent titration technique. This study may introduce a new avenue for designing carbonaceous electrode candidates for future high-performance energy storage devices.
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http://dx.doi.org/10.1039/d0nr06888hDOI Listing
January 2021

Artificial Heterointerfaces Achieve Delicate Reaction Kinetics towards Hydrogen Evolution and Hydrazine Oxidation Catalysis.

Angew Chem Int Ed Engl 2021 Mar 27;60(11):5984-5993. Epub 2021 Jan 27.

Hefei National Laboratory for Physical Sciences at the Microscale, CAS Center for Excellence in Nanoscience, University of Science and Technology of China, Hefei, Anhui, 230026, P. R. China.

Electrochemical water splitting for H production is limited by the sluggish anode oxygen evolution reaction (OER), thus using hydrazine oxidation reaction (HzOR) to replace OER has received great attention. Here we report the hierarchical porous nanosheet arrays with abundant Ni N-Co N heterointerfaces on Ni foam with superior hydrogen evolution reaction (HER) and HzOR activity, realizing working potentials of -43 and -88 mV for 10 mA cm , respectively, and achieving an industry-level 1000 mA cm at 200 mV for HzOR. The two-electrode overall hydrazine splitting (OHzS) electrolyzer requires the cell voltages of 0.071 and 0.76 V for 10 and 400 mA cm , respectively. The H production powered by a direct hydrazine fuel cell (DHzFC) and a commercial solar cell are investigated to inspire future practical applications. DFT calculations decipher that heterointerfaces simultaneously optimize the hydrogen adsorption free energy (ΔG ) and promote the hydrazine dehydrogenation kinetics. This work provides a rationale for advanced bifunctional electrocatalysts, and propels the practical energy-saving H generation techniques.
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http://dx.doi.org/10.1002/anie.202014362DOI Listing
March 2021

The Clusters of Transcription Factors NFATC2, STAT5, GATA2, AP1, RUNX1 and EGR2 Binding Sites at the Induced Enhancers Mediate Gene Transcription in Response to Antigenic Stimulation.

J Immunol 2020 12 13;205(12):3311-3318. Epub 2020 Nov 13.

Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO 80206;

IL-13 plays a critical role in mediating many biological processes responsible for allergic inflammation. Mast cells express mRNA and produce IL-13 protein in response to antigenic stimulation. Enhancers are essential in promoting gene transcription and are thought to activate transcription by delivering essential accessory cofactors to the promoter to potentiate gene transcription. However, enhancers mediating have not been identified. Furthermore, which enhancers detect signals triggered by antigenic stimulation have not yet been defined. In this study, we identified potential mouse enhancers using histone modification monomethylation at lysine residue 4 on histone 3 (H3K4me1) chromatin immunoprecipitation sequencing and acetylation at lysine residue 27 on histone 3 (H3K27ac) chromatin immunoprecipitation sequencing. We used Omni-assay for transposase-accessible chromatin sequencing to determine which accessible regions within the potential enhancers that responded to IgE receptor crosslinking. We also demonstrated that the transcription factor cluster consisting of the NFATC2, STAT5, GATA2, AP1, and RUNX1 binding sites at the proximal enhancer and the transcription factor cluster consisting of the EGR2 binding site at the distal E+6.5 enhancer are critical in sensing the signals triggered by antigenic stimulation. Those enhancers, which are responsive to antigenic stimulation and are constitutively active, cooperate to generate greater transcriptional outputs. Our study reveals a novel mechanism underlying how antigenic stimulation induces robust mRNA expression in mouse mast cells.
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http://dx.doi.org/10.4049/jimmunol.2000985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725890PMC
December 2020

Partially exposed RuP surface in hybrid structure endows its bifunctionality for hydrazine oxidation and hydrogen evolution catalysis.

Sci Adv 2020 Oct 28;6(44). Epub 2020 Oct 28.

Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Materials for Energy Conversion, and Department of Materials Science and Engineering, University of Science and Technology of China, Hefei 230026, Anhui, China.

Replacing the sluggish anode reaction in water electrolysis with thermodynamically favorable hydrazine oxidation could achieve energy-efficient H production, while the shortage of bifunctional catalysts limits its scale development. Here, we presented the scalable one-pot synthesis of partially exposed RuP nanoparticle-decorated carbon porous microsheets, which can act as the superior bifunctional catalyst outperforming Pt/C for both hydrazine oxidation reaction and hydrogen evolution reaction, where an ultralow working potential of -70 mV and an ultrasmall overpotential of 24 mV for 10 mA cm can be achieved. The two-electrode electrolyzer can reach 10 mA cm with a record-low cell voltage of 23 mV and an ultrahigh current density of 522 mA cm at 1.0 V. The DFT calculations unravel the notability of partial exposure in the hybrid structure, as the exposed Ru atoms are the active sites for hydrazine dehydrogenation, while the C atoms exhibit a more thermoneutral value for H* adsorption.
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http://dx.doi.org/10.1126/sciadv.abb4197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608786PMC
October 2020

Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of the management of high-risk population.

Stroke Vasc Neurol 2020 09 13;5(3):270-278. Epub 2020 Aug 13.

Department of Neuroepidemiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China

Aim: Cerebrovascular disease is the leading cause of death and disability in China, causing a huge burden among patients and their families. Hence, stroke prevention is critical, especially in the high-risk population. Here, we present the evidence-based guideline suitable for the Chinese population.

Methods: Literature search of PubMed and Cochrane library (from January 1964 to June 2019) was done. After thorough discussion among the writing group members, recommendations were listed and summarised. This guideline was reviewed and discussed by the fellow writing committees of the Chinese Stroke Association's Stroke.

Results: This evidence-based guideline was written in three parts: controlling the risk factors of stroke, utilisation of antiplatelet agents and assessing the risks of first-ever stroke. All recommendations were listed along with the recommending classes and levels of evidence.

Conclusions: This guideline provides recommendations for primary prevention of cerebrovascular disease among high-risk population in China. Controlling related risk factors, appropriately using antiplatelet agents, assessing the risk of developing first-ever stroke should help reduce the rate of cerebrovascular disease in China.
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http://dx.doi.org/10.1136/svn-2020-000385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548516PMC
September 2020

Cause-specific mortality after diagnosis of thyroid cancer: a large population-based study.

Endocrine 2021 04 8;72(1):179-189. Epub 2020 Aug 8.

Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Purpose: The study aimed to disclose mortality pattern and quantitatively evaluate risks for cause-specific mortality among thyroid cancer survivors.

Methods: We included 173,710 patients from the Surveillance, Epidemiology, and End Results (SEER) database with thyroid cancer diagnosed between 1975 and 2015. Standardized mortality ratio (SMR) was calculated using general US population as the reference. Cumulative incidence function curves were constructed to elaborate crude cause-specific mortality by histology. Cox proportional hazards regression model was adopted to identify predictors for cause-specific mortality, expressed as hazard ratio (HR) and 95% confidence interval (CI).

Results: After a median follow-up of 101 months, 23,040 (13.3%) deaths occurred, of which 29.1% and 21.7% were attributable to thyroid cancer and cardiovascular disease (CVD), respectively. CVD SMRs were 1.14, 1.47, 1.21, and 5.66 in patients with follicular, Hürthle cell, medullary and anaplastic histology, respectively. The adjusted HRs of thyroid cancer-specific mortality were 1.59 (95% CI: 1.46-1.74), 1.87 (95% CI: 1.65-2.12), 3.66 (95% CI: 3.31-4.05), and 12.65 (95% CI: 11.50-13.92) for follicular, Hürthle cell, medullary, and anaplastic histology, respectively, as compared with papillary histology; HRs of CVD-specific mortality were 1.23 (95% CI: 1.12-1.34), 1.27 (95% CI: 1.11-1.46), 1.13 (95% CI: 0.96-1.33), and 1.60 (95% CI: 1.19-2.16), respectively. Older age, male sex, nonwhite race, unmarried status, and advanced stage were independent predictors of CVD-specific mortality, while receiving surgery and radiotherapy were protective against CVD-specific mortality.

Conclusions: We disclosed distinct mortality patterns by histology and identified predictors of CVD-specific mortality in thyroid cancer survivors, supporting CVD intervention for aggressive thyroid cancer.
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http://dx.doi.org/10.1007/s12020-020-02445-8DOI Listing
April 2021

iTRAQ-Based Comparative Proteomic Analysis of Larval Midgut From the Beet Armyworm, (Hübner) (Lepidoptera: Noctuidae) Challenged With the Entomopathogenic Bacteria .

Front Physiol 2020 8;11:442. Epub 2020 May 8.

Key Laboratory of Bio-Pesticide Innovation and Application of Guangdong Province, College of Agriculture, South China Agricultural University, Guangzhou, China.

Entomopathogenic bacteria is widely used as an environmentally friendly biocontrol agent against various pests, including . Understanding the immune defense mechanism of through comparative proteomic analysis can identify the key proteins expressed in response to the microbial infection. Here, we employed the as isobaric tags for relative and absolute quantification (iTRAQ) technique to investigate the effects of on the proteomic expression of Based on the molecular functional analysis, the differentially expressed proteins (DEPs) were mainly involved in the binding process and catalytic activities. Further bioinformatics analysis revealed important DEPs that played a crucial role in innate immunity of with recognition (C-type lectin), melanization (propanol oxidase 3, serine protease, Serine-type carboxypeptidase activity, clip domain serine protease 4), antimicrobial activity (lysozyme, lysozyme-like, gloverin, cecropin B), detoxification (acetyl-CoA C-acetyltransferase, 3-dehydroecdysone 3-alpha-reductase, glucuronosyltransferase, glutathione S-transferase) and others. The Quantitative real-time PCR (qRT-PCR) results further indicated the significant upregulation of the immune-related genes in following infection. To the best of our knowledge, this is the first iTRAQ based study to characterize mediated proteomic changes in and identified important immune-related DEPs. The results of this study will provide an essential resource for understanding the host-pathogen interactions and the development of novel microbial biopesticides against various pests.
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http://dx.doi.org/10.3389/fphys.2020.00442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227483PMC
May 2020

Manipulating dehydrogenation kinetics through dual-doping CoN electrode enables highly efficient hydrazine oxidation assisting self-powered H production.

Nat Commun 2020 Apr 15;11(1):1853. Epub 2020 Apr 15.

Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Materials for Energy Conversion, Department of Materials Science and Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China.

Replacing sluggish oxygen evolution reaction (OER) with hydrazine oxidation reaction (HzOR) to produce hydrogen has been considered as a more energy-efficient strategy than water splitting. However, the relatively high cell voltage in two-electrode system and the required external electric power hinder its scalable applications, especially in mobile devices. Herein, we report a bifunctional P, W co-doped CoN nanowire array electrode with remarkable catalytic activity towards both HzOR (-55 mV at 10 mA cm) and hydrogen evolution reaction (HER, -41 mV at 10 mA cm). Inspiringly, a record low cell voltage of 28 mV is required to achieve 10 mA cm in two-electrode system. DFT calculations decipher that the doping optimized H* adsorption/desorption and dehydrogenation kinetics could be the underlying mechanism. Importantly, a self-powered H production system by integrating a direct hydrazine fuel cell with a hydrazine splitting electrolyzer can achieve a decent rate of 1.25 mmol h at room temperature.
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http://dx.doi.org/10.1038/s41467-020-15563-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160107PMC
April 2020

Met allele Is Associated With Lower Cognitive Function in Poststroke Rehabilitation.

Neurorehabil Neural Repair 2020 03 2;34(3):247-259. Epub 2020 Feb 2.

Stroke Biological Recovery Laboratory, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, MA, USA.

The identification of a genetic role for cognitive outcome could influence the design of individualized treatment in poststroke rehabilitation. The aim of this study is to determine whether brain-derived neurotrophic factor () Val66Met polymorphism is independently associated with poststroke functional outcome. A total of 775 stroke patients with genomic data were identified from the Partners HealthCare Biobank, which contains a large number of genotypes from Biobank's consented patients. Of 775 stroke patients who met the inclusion/exclusion criteria, 86 were enrolled. Functional outcomes were assessed using the Functional Independence Measure scores at the time of admission and discharge. Logistic and linear regression models adjusted for covariate variables, including age, sex, and medical conditions, were used to evaluate the association between Val66Met and functional outcome. We detected a significant correlation between Met alleles and lower cognitive function at discharge in both ischemic and hemorrhagic stroke patients. Genotyping findings confirmed that Met allele frequency was higher in contrast to Val/Val allele frequency in lower cognitive functional recovery. Furthermore, after adjusting for covariate variables, Met alleles were found to be associated with lower cognitive outcome [ = .003; odds ratio (OR) = 5.95 (1.81-19.52)] and recovery [ = .006; OR = 3.16 (1.4-7.15)], especially with lower problem solving, expression, and social recovery in all stroke patients. Met allele carriers exhibited impaired poststroke cognitive function. The BDNF genotype may be a useful predictor of cognitive function in inpatient poststroke rehabilitation.
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http://dx.doi.org/10.1177/1545968320902127DOI Listing
March 2020

Dual-Functional Template-Directed Synthesis of MoSe/Carbon Hybrid Nanotubes with Highly Disordered Layer Structures as Efficient Alkali-Ion Storage Anodes beyond Lithium.

ACS Appl Mater Interfaces 2020 Jan 31;12(2):2390-2399. Epub 2019 Dec 31.

School of Chemistry and Materials Science , University of Science and Technology of China , Hefei , Anhui 230026 , China.

Sodium/Potassium-ion batteries (SIBs/PIBs) have recently received tremendous attention because of their particular features of cost-effectiveness and promising energy density, which hold great potential for large-scale applications. Nevertheless, it still has a common bottleneck issue that is the sluggish kinetics of Na/K intercalation, which raises more rigorous requirement on the electrode candidates regarding the morphology, dimension, and architecture. Herein, we have constructed unique MoSe-based hybrid nanotubes with wall structures composed of highly disordered MoSe layers embedded in phosphorus and nitrogen co-doped carbon matrix (denoted MoSe⊂PNC-HNTs), by a facile two-step strategy using Se nanorods as the dual-functional template, i.e., shape-directed agent and in situ selenization resources. Benefitting from the combined features of the one-dimensional (1D) hollow interior, hybrid wall structure with high disorder, and the phosphorus and nitrogen co-doping-induced abundant defect sites in the carbon matrix, the MoSe⊂PNC-HNT anode exhibits high specific capacities of 280 and 262 mA h g over 200 cycles at the current density of 0.1 A g for Na and K storage, respectively, and achieves remarkable capacity retention rates of 87.0% at 2 A g over 3500 cycles for Na-ion storage and 80.1% at 1 A g after 500 cycles for K-ion storage.
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http://dx.doi.org/10.1021/acsami.9b17473DOI Listing
January 2020

MXene-TiC/CuS nanocomposites: Enhanced peroxidase-like activity and sensitive colorimetric cholesterol detection.

Mater Sci Eng C Mater Biol Appl 2019 Nov 19;104:110000. Epub 2019 Jul 19.

College of Chemical Engineering and Materials Science, Quanzhou Normal University, Quanzhou, Fujian Province, China. Electronic address:

Nanomaterials with enzyme-like activity have attracted much attention recently. Herein, we report the synthesis of a new type of 2D MXene-TiC/CuS nanocomposites with peroxidase-like activity using a simple hydrothermal approach. Significantly, compared with the individual MXene-TiC nanosheets or CuS nanoparticles, the MXene-TiC/CuS nanocomposites show a synergistically enhanced peroxidase-like activity and can be used as an efficient mimetic peroxidase to catalyze the reaction of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (HO), causing a blue color change. Kinetic studies reveal that the MXene-TiC/CuS nanocomposites have a higher catalytic activity to TMB than their single components, and the catalytic reaction follows the ping-pong mechanism. The MXene-TiC/CuS nanocomposites are used for the colorimetric determination of cholesterol with a linear range of 10-100 μM and a limit of detection (LOD) of 1.9 μM. Our results show that the MXene-TiC/CuS nanocomposites based colorimetric cholesterol biosensor is cost-effective, sensitive, and selective, which has potential application in HO and cholesterol detection and clinic medicine diagnostics.
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http://dx.doi.org/10.1016/j.msec.2019.110000DOI Listing
November 2019

miR-222 inhibits cardiac fibrosis in diabetic mice heart via regulating Wnt/β-catenin-mediated endothelium to mesenchymal transition.

J Cell Physiol 2020 03 6;235(3):2149-2160. Epub 2019 Aug 6.

Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

miR-222 participates in many cardiovascular diseases, but its effect on cardiac remodeling induced by diabetes is unclear. This study evaluated the functional role of miR-222 in cardiac fibrosis in diabetic mice. Streptozotocin (STZ) was used to establish a type 1 diabetic mouse model. After 10 weeks of STZ injection, mice were intravenously injected with Ad-miR-222 to induce the overexpression of miR-222. miR-222 overexpression reduced cardiac fibrosis and improved cardiac function in diabetic mice. Mechanistically, miR-222 inhibited the endothelium to mesenchymal transition (EndMT) in diabetic mouse hearts. Mouse heart fibroblasts and endothelial cells were isolated and cultured with high glucose (HG). An miR-222 mimic did not affect HG-induced fibroblast activation and function but did suppress the HG-induced EndMT process. The antagonism of miR-222 by antagomir inhibited HG-induced EndMT. miR-222 regulated the promoter region of β-catenin, thus negatively regulating the Wnt/β-catenin pathway, which was confirmed by β-catenin siRNA. Taken together, our results indicated that miR-222 inhibited cardiac fibrosis in diabetic mice via negatively regulating Wnt/β-catenin-mediated EndMT.
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http://dx.doi.org/10.1002/jcp.29119DOI Listing
March 2020

Designed One-Pot Strategy for Dual-Carbon-Protected Na V (PO ) Hybrid Structure as High-Rate and Ultrastable Cathode for Sodium-Ion Batteries.

Chemistry 2019 Oct 17;25(57):13094-13098. Epub 2019 Sep 17.

Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Materials for Energy Conversion, Department of Materials Science and Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China.

Sodium-ion batteries have attracted tremendous attention due to their much lower cost and similar working principle compared with lithium-ion batteries, which have been invited great expectation as energy storage devices in grid-level applications. The sodium superionic conductor Na V (PO ) has been considered as a promising cathode candidate; however, its intrinsic low electronic conductivity results in poor rate performance and unsatisfactory cycling performance, which severely impedes its potential for practical applications. Herein, we developed a facile one-pot strategy to construct dual carbon-protected hybrid structure composed of carbon coated Na V (PO ) nanoparticles embedded with carbon matrix with excellent rate performance, superior cycling stability and ultralong lifespan. Specifically, it can deliver an outstanding rate performance with a 51.5 % capacity retention from 0.5 to 100 C and extraordinary cycling stability of 80.86 % capacity retention after 6000 cycles at the high rate of 20 C. The possible reasons for the enhanced performance could be understood as the synergistic effects of the strengthened robust structure, facilitated charge transfer kinetics, and the mesoporous nature of the Na V (PO ) hybrid structure. This work provides a cost-effective strategy to effectively optimize the electrochemical performance of a Na V (PO ) cathode, which could contribute to push forward the advance of its practical applications.
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http://dx.doi.org/10.1002/chem.201902400DOI Listing
October 2019

Hospital use in survivors of transient ischaemic attack compared with survivors of stroke in central China: a nested case-control study.

BMJ Open 2019 07 9;9(7):e024052. Epub 2019 Jul 9.

Department of Epidemiology and Biostatistics, Zhengzhou University, Zhengzhou, China.

Objectives: There is a lack of knowledge regarding post-discharge hospitalisation utilisation after transient ischaemic attack (TIA) in China. The aim of this study is to quantify rehospitalisation use in survivors of TIA compared with their own previous hospital use and matched survivors of stroke.

Design: Nested case-control study of electronic medical records datasets.

Setting: 958 hospitals in Henan, China, from July 2012 to December 2015.

Participants: In total, 4823 survivors of stroke were matched to the TIA cohort (average age: 64.5 years; proportion of men: 48.4%) at a 1:1 ratio. All subjects with an onset of stroke/TIA were recorded with a 1-year look-back and follow-up.

Outcome Measures: Adjusted difference-in-differences (DID) values in 1-year hospital lengths of stay (LOSs) and readmission within 7, 30 and 90 days.

Results: There was an increase in hospital admissions in survivors of TIA in the year after the index hospitalisation compared with the prior year. Of the 2449 rehospitalisation events that occurred during the first year after TIA, stroke (20.6%) was the most common reason for rehospitalisation. There was no difference in the stroke-specific readmission rates between the TIA and stroke cohorts (p=0.198). The TIA cohort had fewer readmissions within 30 days and 90 days after all-cause discharge compared with the controls. The corresponding covariate-adjusted DID values were -3.5 percentage points (95% CI -5.3 to -1.8) and -4.5 (95% CI -6.5 to -2.4), respectively. A similar trend was observed in the 1-year LOS. In the stratified analysis, the DID reductions were not significant in patients with more comorbidities or in rural patients.

Conclusions: Compared with survivors of stroke, survivors of TIA use fewer hospital resources up to 1 year post-discharge. Greater attention to TIAs among patients with more comorbidities and rural patients may provide an opportunity to reduce hospital use.
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http://dx.doi.org/10.1136/bmjopen-2018-024052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624025PMC
July 2019

Low-cost high-performance hydrogen evolution electrocatalysts based on Pt-CoP polyhedra with low Pt loading in both alkaline and neutral media.

Dalton Trans 2019 Jun;48(24):8920-8930

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P.R. China.

Platinum is the most active and commonly used electrocatalyst for hydrogen evolution reaction (HER). However, its expensive price and scarce supply limit its world-wide use for mass production of H2 by water electrolysis. Promising candidates for high-performance hydrogen evolution reaction with exceptionally low Pt loading are urgently required to obtain clean and sustainable chemical fuels. Herein, yolk-shell Pt-CoP polyhedra were prepared to realize low Pt loading on low-cost CoP polyhedral substrates via low-temperature calcination and phosphorization of ZIF-67 combined with a subsequent microwave-assisted platinum reduction process. Owing to the unique yolk-shell structure, large surface area, numerous active sites, trace Pt modification and improved conductivity, the resultant catalyst exhibits highly efficient electrocatalytic activities for the HER with the low overpotentials of only 48 mV and 88 mV at 10 mA cm-2 and excellent stability in the 1 M KOH and 1 M PBS solution, superior to most of the newly reported noble metal-based or transition metal-based catalysts, even the state-of-art Pt/C catalysts.
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http://dx.doi.org/10.1039/c9dt01118hDOI Listing
June 2019

UBE2T promotes proliferation and regulates PI3K/Akt signaling in renal cell carcinoma.

Mol Med Rep 2019 Aug 3;20(2):1212-1220. Epub 2019 Jun 3.

Department of Interventional Radiology, First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154003, P.R. China.

Renal cell carcinoma (RCC) is a common malignant tumor globally. The overall survival of patients with RCC is poor; one important factor is tumor heterogeneity. Ubiquitin‑conjugating enzyme E2T (UBE2T) has been reported to act as an oncogene in various types of cancer; however, its role in RCC has yet to be investigated. In the present study, UBE2T was demonstrated via reverse transcription‑quantitative PCR analysis to be significantly upregulated in RCC samples and cell lines compared with in normal tissue and cells. Additionally, UBE2T expression was significantly associated with late tumor stage and high grade in patients with RCC, and patients with high UBE2T expression exhibited poor prognosis compared with patients with low expression. Following knockdown of UBE2T in 786‑O cells using RNA interference technology, the proliferation and colony formation of cells were inhibited as determined by an MTT assay and crystal violet staining, respectively; however, the migration and invasion of 786‑O cells were not affected, as determined by wound‑healing assay and Transwell assays, respectively. Xenograft RCC tumor growth in vivo was also significantly suppressed. The expression levels of two mesenchymal cell markers, N‑cadherin and vimentin, were reduced following UBE2T knockdown, whereas E‑cadherin and fibronectin levels were increased as determined by western blotting, indicating that epithelial‑mesenchymal transition was suppressed. In addition, the phosphorylation levels of PI3K, Akt and mTOR were notably decreased following UBE2T knockdown, but were increased when UBE2T was overexpressed. Wortmannin, an Akt inhibitor, reversed the UBE2T overexpression‑induced increase in the phosphorylation of PI3K, Akt and mTOR. Similarly, the UBE2T overexpression‑induced promotion of 786‑O cell proliferation was also attenuated by wortmannin. In conclusion, UBE2T promoted the proliferation of RCC cells by regulating PI3K/Akt signaling, suggesting it may be a novel target for the treatment of patients with RCC.
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http://dx.doi.org/10.3892/mmr.2019.10322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625406PMC
August 2019

The role of the triglyceride (triacylglycerol) glucose index in the development of cardiovascular events: a retrospective cohort analysis.

Sci Rep 2019 05 13;9(1):7320. Epub 2019 May 13.

Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, P.R. China.

This study aimed to evaluate the role of the triglyceride (triacylglycerol) glucose (TyG) index in predicting and mediating the development of cardiovascular disease (CVD). This cohort study included 6078 participants aged over 60 years who participated in a routine health check-up programme from 2011 to 2017. The competing risk model, cox regression model and multimediator analyses were performed. TyG was calculated as ln [fasting triglyceride (mg/dl) × fasting plasma glucose (mg/dl)/2]. During a median 6 years of follow-up, 705 (21.01/1000 person-years) CVD events occurred. In fully adjusted analyses, quartiles 3 and 4 versus quartile 1 of TyG index (adjusted subhazard ratios [SHRs] 1.33 [95% CI: 1.05-1.68] and 1.72 [1.37-2.16]) were associated with an increased risk of CVD events. The continuous time-dependent TyG remained significant in predicting CVD events (adjusted hazard ratios [HR] 1.43 [1.24-1.63]). The adverse estimated effects of body mass index (BMI) or resting heart rate (RHR) on CVD mediated through the joint effect of the baseline and follow-up TyG index. In addition, an effect mediated only through the follow-up TyG existed (P < 0.05). Thus, it is necessary to routinely measure the TyG. The TyG index might be useful for predicting CVD events in clinical practice.
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http://dx.doi.org/10.1038/s41598-019-43776-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513983PMC
May 2019

Ambient Fast Synthesis and Active Sites Deciphering of Hierarchical Foam-Like Trimetal-Organic Framework Nanostructures as a Platform for Highly Efficient Oxygen Evolution Electrocatalysis.

Adv Mater 2019 Jun 11;31(23):e1901139. Epub 2019 Apr 11.

Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Materials for Energy Conversion, Department of Materials Science and Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China.

Metal-organic frameworks (MOFs) have attracted tremendous interest due to their promising applications including electrocatalysis originating from their unique structural features. However, it remains a challenge to directly use MOFs for oxygen electrocatalysis because it is quite difficult to manipulate their dimension, composition, and morphology of the MOFs with abundant active sites. Here, a facile ambient temperature synthesis of unique NiCoFe-based trimetallic MOF nanostructures with foam-like architecture is reported, which exhibit extraordinary oxygen evolution reaction (OER) activity as directly used catalyst in alkaline condition. Specifically, the (Ni Co ) Fe -MOF-NF delivers a minimum overpotential of 257 mV to reach the current density of 10 mA cm with a small Tafel slope of 41.3 mV dec and exhibits high durability after long-term testing. More importantly, the deciphering of the possible origination of the high activity is performed through the characterization of the intermediates during the OER process, where the electrochemically transformed metal hydroxides and oxyhydroxides are confirmed as the active species.
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http://dx.doi.org/10.1002/adma.201901139DOI Listing
June 2019

Light-exposure at night impairs mouse ovary development via cell apoptosis and DNA damage.

Biosci Rep 2019 05 2;39(5). Epub 2019 May 2.

College of Life Sciences, Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao Agricultural University, Qingdao 266109, China

The alternation of light and dark rhythm causes a series of physiological, biochemical and metabolic changes in animals, which also alters the growth and development of animals, and feeding, migration, reproduction and other behavioral activities. In recent years, many studies have reported the effects of long-term (more than 6 weeks) illumination on ovarian growth and development. In the present study, we observed the damage, repair and apoptosis of ovarian DNA in a short period of illumination. The results showed that, in short time (less than 2 weeks) illumination conditions, the 24-h light treatment caused the reduction of total ovarian follicle number and down-regulation of circadian clock related genes. Furthermore, the changed levels of serum sex hormones were also detected after 24-h light exposure, of which the concentrations of LH (luteinizing hormone), FSH (follicle-stimulating hormone) and E2 (estradiol) were increased, but the concentration of PROG (progesterone) was decreased. Moreover, 24-h light exposure increased the expression of DNA damage and repair related genes, the number of TUNEL and RAD51 positive cells. These results indicated that 24-h light exposure for 4, 8 and 12 days increased DNA damage and cell apoptosis, thereby affecting the development of ovary.
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http://dx.doi.org/10.1042/BSR20181464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499499PMC
May 2019

MiR-451 antagonist protects against cardiac fibrosis in streptozotocin-induced diabetic mouse heart.

Life Sci 2019 May 11;224:12-22. Epub 2019 Mar 11.

Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address:

Aims: MicroRNAs (miRNAs or miRs) are a large class of small noncoding RNAs. The present study aims to evaluate the effect of miR-451 on cardiac remodeling in diabetic cardiomyopathy.

Main Methods: Mice were injected with streptozotocin (STZ) to induce diabetes. Twelve weeks after final STZ injection, mice were subjected to myocardial injection of adenovirus (Ad)-shmiR-451 to knock down miR-451. Mouse heart endothelial cells (MHECs) were treated with a miR-451 antagomir to inhibit miR451 and were exposed to high glucose.

Key Findings: Sixteen weeks after STZ injection, mice exhibited no significant cardiac hypertrophy but did exhibit serious cardiac fibrosis. MiR-451 knockdown attenuated cardiac fibrosis and improved cardiac function. Moreover, we found that miR-451 knockdown suppressed endothelial-to-mesenchymal transition (EndMT) in diabetic mouse hearts. Hyperglycemia-induced EndMT in MHECs was attenuated by the miR-451 antagomir. Activation of AMPKa1/mTOR was decreased in diabetic mouse heart tissue and hyperglycemia-stimulated MHECs, which was increased following miR-451 knockdown or inhibition. AMPKa1 siRNA abrogated the anti-EndMT effects of miR-451 knockdown in MHECs.

Significance: miR-451 participates in the pathology of diabetic cardiomyopathy via AMPKa1-regulated EndMT in endothelial cells.
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http://dx.doi.org/10.1016/j.lfs.2019.02.059DOI Listing
May 2019

Combining Diffusion-Weighted Imaging Patterns with ABCD2 Score Predicts Stroke Risk after Transient Ischemic Attack.

Curr Neurovasc Res 2018 ;15(4):298-304

Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.

Background: Recent studies indicated that multiple acute infarctions on Diffusion- Weighted Imaging (DWI) were associated with a higher risk of stroke.

Objective: The study aims to estimate the association of different infarction patterns and ABCD2 score with the prognosis of Transient Ischemic Attack (TIA).

Method: We prospectively analyzed the data from TIA database of the First Affiliated Hospital of Zhengzhou University. The predictive outcome was a 90-day ischemic stroke. Cox proportional hazards model was used to evaluate the predictive value of risk factors associated with stroke. The receiver-operating characteristics curves were plotted, and the predictive value was assessed by computing the Area Under the Curve (AUC).

Results: A total of 1376 eligible patients were enrolled. DWI patterns were significant predictors for stroke (single acute infarction: hazard ratio [HR] =2.942, p <0.001; multiple acute infarctions: HR =5.552, p <0.001, in comparison with no acute infarction). Patients with both multiple infarctions and ABCD2 ≥4 were associated with approximately 15.5-fold risk of stroke at 90 days (28.8% vs. 2.1%, HR =15.455, 95% confidence interval [CI], 7.946-30.057, p <0.001), compared with those with no infarction or ABCD2 <4. The ABCD2+ DWI patterns showed a better discrimination with an AUC of 0.765 (95% CI, 0.741-0.787) than the ABCD2 score (AUC =0.651; 95% CI, 0.625-0.676; Z =4.777; p <0.0001) and ABCD3-I score (AUC =0.724; 95% CI, 0.700- 0.748; Z =2.697; p =0.007).

Conclusion: Combining infarction patterns with ABCD2 score could enhance the predictive value for early stroke risk in TIA.
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http://dx.doi.org/10.2174/1567202616666181204121636DOI Listing
July 2019

Role of β-Estradiol in MCF-7 Breast Cancer Cell Line Based on the Bioinformatics Analysis.

Gynecol Obstet Invest 2019 23;84(3):268-276. Epub 2018 Nov 23.

Core Laboratory of Translational Medicine, Chinese PLA General Hospital, Beijing, China,

Background: This study aimed to investigate the action mechanism of β-estradiol in MCF-7 breast cancer (BC) cells.

Methods: The cell samples were sequenced using Hiseq 2000, including 2 MCF-7 controls and 2 samples treated with β-estradiol. Differentially expressed genes (DEGs) were screened using the NOISeq package in R, followed by the functions and pathways analyses using Database for Annotation, Visualization and Integrated Discovery. DEGs associated with β-estradiol were selected using the WbeGestalt software, and the corresponding target miRNAs of these genes were analyzed from different miRNA databases. Additionally, protein-protein interaction network of the drug-associated genes was constructed using Cytoscape.

Results: A total of 1,835 DEGs in BC samples were screened. Thereinto, DEGs associated with BC (17 upregulated and 28 downregulated DEGs) were involved in the regulation of cell proliferation, response to endogenous stimulus, and response to hormone stimulus, while the genes participated in several significant pathways. Cyclin D1, estrogen receptor 1, catechol-O-methyltransferase, and cathepsin D (CTSD; hub genes) were the predicted new genes associated with β-estradiol. Besides, hsa-miR-140-3p was the only target miRNA of CTSD.

Conclusion: β-Estradiol may play a key role in contributing to BC progression and metastasis by regulating the expression of the selected genes.
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http://dx.doi.org/10.1159/000487945DOI Listing
August 2019

Synthetic imaging through wavy water surface with centroid evolution.

Opt Express 2018 Oct;26(20):26009-26019

Imaging through a wavy water surface is a challenging task, as the wavy water surface introduces anisoplanatism effects difficult to model and track. A typical recovery method is usually involving multiple-stage processing on a pre-acquired image sequence. A new progressive restoration scheme is demonstrated, it can run simultaneously with image acquisition and mitigate both distortion and blur progressively. This method extends the anisotropic evolution in lucky region fusion with a novel progressive optical flow based de-warping scheme, centroid evolution. A comparison has been made with other state-of-art techniques, the proposed method can create comparable results, even with much less frames acquired. Experiments with real through-water scenes have also proved the effectiveness of the method.
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http://dx.doi.org/10.1364/OE.26.026009DOI Listing
October 2018

Effects of air pollutants on occurrences of influenza-like illness and laboratory-confirmed influenza in Hefei, China.

Int J Biometeorol 2019 Jan 31;63(1):51-60. Epub 2018 Oct 31.

Department of Biostatistics, School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Xuhui District, Shanghai, 200231, China.

Accumulating evidence suggests that air pollution is a risk factor for adverse respiratory and cardiovascular health outcomes. However, the different impacts of exposure to air pollutants on influenza virus activity and influenza-like illness (ILI) have not been well documented in epidemiological studies. We examined the association between air pollutants of particular matters < 2.5 μm (PM), particular matters < 10 μm (PM), nitrogen dioxide (NO), sulfur dioxide (SO), and influenza occurrences in Hefei, China, from December 2013 to December 2015 by generalized Poisson additive regression models. The result suggested that PM and PM had similar effects on clinical ILI and influenza incidence. PM was negatively associated with clinical ILI (relative risk (RR) 0.980, 95% confidence interval (CI) 0.974-0.987), while PM were positively associated with clinical ILI (RR 1.040; 95% CI 1.032-1.049). RRs for the laboratory-confirmed cases of influenza were 0.813 (95% CI, 0.755-0.875) for PM and 1.216 (95% CI, 1.134-1.304) for PM. Nevertheless, the impacts of SO and NO on ILI and influenza were distinct. SO had significant influence on laboratory-confirmed influenza and had no significant linear relationship with ILI. NO was negatively correlated with influenza but had no obvious effect on clinical ILI cases. The present study contributes novel evidence on understanding of the effects of various air pollutants on influenza activities, and these findings can be useful and important for the development of influenza surveillance and early warning systems.
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http://dx.doi.org/10.1007/s00484-018-1633-0DOI Listing
January 2019