Publications by authors named "Yao Wang"

2,644 Publications

  • Page 1 of 1

Palladium/Amino Acid Co-catalyzed Atroposelective C-H Olefination to Access Tetra-Ortho-Substituted Atropisomers Featuring 2,2'-Difluoro-1-biaryl Scaffolds.

Org Lett 2022 Aug 11. Epub 2022 Aug 11.

College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, China.

Despite the great advancement in atroposelective synthesis in the past decades, the enantioselective synthesis of 2,2'-difluoro-1-biaryls is unprecedented. Herein, a palladium and chiral amino acid catalyzed atroposelective C-H olefination to construct the axially chiral 2,2'-difluoro-1-biaryls is reported. A variety of polyfluoro-substituted biaryls were forged under mild conditions in good yields with excellent enantioselectivity (up to 99% ee). The potential application was demonstrated by a gram-scale synthesis and synthetic transformations.
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http://dx.doi.org/10.1021/acs.orglett.2c02303DOI Listing
August 2022

VisRecall: Quantifying Information Visualisation Recallability Via Question Answering.

IEEE Trans Vis Comput Graph 2022 Aug 11;PP. Epub 2022 Aug 11.

Despite its importance for assessing the effectiveness of communicating information visually, fine-grained recallability of information visualisations has not been studied quantitatively so far. In this work, we propose a question-answering paradigm to study visualisation recallability and present VisRecall - a novel dataset consisting of 200 visualisations that are annotated with crowd-sourced human (N = 305) recallability scores obtained from 1,000 questions of five question types. Furthermore, we present the first computational method to predict recallability of different visualisation elements, such as the title or specific data values. We report detailed analyses of our method on VisRecall and demonstrate that it outperforms several baselines in overall recallability and FE-, F-, RV-, and U-question recallability. Our work makes fundamental contributions towards a new generation of methods to assist designers in optimising visualisations.
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http://dx.doi.org/10.1109/TVCG.2022.3198163DOI Listing
August 2022

Relationships between self-efficacy, coping-style and quality of work-life among nursing managers in China: A cross-sectional study.

J Nurs Manag 2022 Aug 9. Epub 2022 Aug 9.

Department of Nursing, Zigong First People's Hospital, Zigong, Sichuan, China.

Aim: To investigate the quality of work-life among nursing managers in China and analyze the relationships between self-efficacy, coping-style, and quality of work-life.

Background: Self-efficacy, coping-style, and quality of work-life play significant roles in the stability of nursing teams, the quality of clinical care, and patient safety. Although some factors influencing quality of work-life have been identified, there is no large-scale study of the relationships among self-efficacy, coping-style, and quality of work-life of nursing managers. Strategies to strengthen the quality of work-life of nursing managers should be developed by exploring the relationships between the three variables.

Methods: A nationwide cross-sectional study was conducted. A total of 1498 nursing managers from 51 tertiary general hospitals in 20 provinces in China were selected for the study using multistage stratified proportional sampling. Registered full-time nursing managers with more than one year of management experience were eligible for the study. The participants completed online questionnaires to assess their self-efficacy, coping-style, and work-related quality of life. The data were analyzed using descriptive analysis, Pearson's correlation, hierarchical multiple linear regression, and structural equation modelling to verify the relationships between variables.

Results: The quality of work-life score for the nursing managers surveyed was 3.74 ± 0.56 out of a possible five. Self-efficacy was positively correlated with quality of work-life (β = 0.484, P < 0.01) over all demographic variables. Positive coping was also positively associated with quality of work-life (β = 0.404, P < 0.01). Self-efficacy and positive coping explained 22.7% and 14.2% of the variance in the quality of work-life, respectively. Structural equation modelling indicated that self-efficacy positively and directly predicted the quality of work-life (β = 0.395, P < 0.001), and indirectly affected quality of work-life via positive coping (β = 0.186, P < 0.001), but not via negative coping (β = 0.005, P > 0.05). The final model could explain 44% of the variance in the quality of work-life.

Conclusion: Self-efficacy was positively correlated with quality of work-life among Chinese nursing managers, and positive coping partially mediated this relationship. The results suggest that self-efficacy and positive coping are pivotal facilitators for improving the quality of work-life and need to be taken into account in measures to improve the quality of work-life of nursing managers.

Implications For Nursing Management: Hospital administrators should recognize the importance of nursing managers' work-life quality to promote both the stability of nursing teams and the quality of clinical care and safety provided. They should help nursing managers foster self-efficacy and active coping abilities through incentive measures and provide positive coping training courses to enhance their quality of work-life.
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http://dx.doi.org/10.1111/jonm.13753DOI Listing
August 2022

Mitophagy-mediated molecular subtypes depict the hallmarks of the tumour metabolism and guide precision chemotherapy in pancreatic adenocarcinoma.

Front Cell Dev Biol 2022 22;10:901207. Epub 2022 Jul 22.

Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Mitophagy is closely related to cancer initiation and progression. However, heterogeneity with reference to mitophagy remains unexplored in pancreatic adenocarcinoma (PAAD). We used Reactome database to download the mitophagy-related, glycolysis-related and cholesterol biosynthesis-related signaling pathways. Unsupervised clustering using the "ConsensusClusterPlus" R package was performed to identify molecular subtypes related to mitophagy and metabolism. Prognosis-related mitophagy regulators were identified by univariate Cox regression analysis. Receiver operating characteristics (ROC) and Kaplan-Meier (K-M) survival analyses were used to assess the diagnostic and prognostic role of the hub genes and prognosis risk model. Weighted gene co-expression network analysis (WGCNA) was utilized for screening the mitophagy subtype-related hub genes. Metascape was utilized to carry out functional enrichment analysis. The "glmnet" R package was utilised for LASSO, and the "e1071" R package was utilised for SVM. Chemotherapeutic drug sensitivity was estimated using the R package "pRRophetic" and Genomics of Drug Sensitivity in Cancer (GDSC) database. The nomogram was established by the "rms" R package. Three distinct mitophagy subtypes (low, high and intermediate) of PAAD were identified based on the landscape of mitophagy regulators. The high mitophagy subtype had the worst prognosis, highest mRNA expression-based stemness index scores and most hypoxic environment compared to the other subtypes. Additionally, glycolysis and cholesterol biosynthesis were significantly elevated. Three mitophagy subtype-specific gene signatures ( and ) were extracted using WGCNA and machine learning. Moreover, PAAD tumours were insensitive to Erlotinib, Sunitinib and Imatinib in the high mitophagy subtype and high and expressed subtypes. Furthermore, and affected immune cell infiltration (M1 and CD8Tcm), resulting in the altered prognosis of patients with PAAD. A nomogram was constructed to screen patients with the low mitophagy subtype, which showed a higher sensitivity to chemotherapeutic agents. Based on various bioinformatics tools and databases, the PAAD heterogeneity regarding mitophagy was systematically examined. Three different PAAD subtypes having different outcomes, metabolism patterns and chemosensitivity were observed. Moreover, three novel biomarkers that are closely associated with mitophagy and have the potential to guide individualised treatment regimens in PAAD were obtained.
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http://dx.doi.org/10.3389/fcell.2022.901207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353335PMC
July 2022

A Cost-Effectiveness Analysis of Comprehensive Smoking-Cessation Interventions Based on the Community and Hospital Collaboration.

Front Public Health 2022 22;10:853438. Epub 2022 Jul 22.

School of Public Health, Capital Medical University, Beijing, China.

Background: The prevalence of cigarette smoking in China is high and the utilization of smoking cessation clinics is very low. Multicomponent smoking cessation interventions involving community and hospital collaboration have the potential to increase the smoking cessation rate. However, the cost-effectiveness of this intervention model is unknown.

Methods: We conducted a smoking cessation intervention trial in 19 community health service centers in Beijing, China. A cost-effectiveness analysis was performed from a societal perspective to compare three strategies of smoking cessation: no intervention (NI), pharmacological intervention (PI), and comprehensive intervention (CI) (PI plus online health promotion). A Markov model, with a time horizon of 20 years, was used to simulate the natural progression of estimated 10,000 male smokers. A cross-sectional survey was conducted to obtain data on costs and quality-adjusted life years (QALYs) by using the five-level EuroQol-5-dimension (EQ-5D-5L) questionnaire. Probabilistic sensitivity analysis was performed to explore parameters of uncertainty in the model.

Results: A total of 680 participants were included in this study, including 283 in the PI group and 397 in the CI group. After 6 months of follow-up, the smoking cessation rate reached 30.0% in the CI group and 21.2% in the PI group. Using the Markov model, compared with the NI group, the intervention strategies of the PI group and the CI group were found to be cost-effective, with an incremental cost-effectiveness ratio (ICER) of $535.62/QALY and $366.19/QALY, respectively. The probabilistic sensitivity analysis indicated that the CI strategy was always the most cost-effective intervention.

Conclusion: CI for smoking cessation, based in hospital and community in China, is more cost-effective than PI alone. Therefore, this smoking cessation model should be considered to be implemented in healthcare settings.
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http://dx.doi.org/10.3389/fpubh.2022.853438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354545PMC
July 2022

Long-Term Cost-Effectiveness Analysis of Once-Weekly Semaglutide versus Dulaglutide in Patients with Type 2 Diabetes with Inadequate Glycemic Control in China.

Diabetes Ther 2022 Aug 8. Epub 2022 Aug 8.

Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.

Introduction: The objective of the current study was to assess the long-term cost-effectiveness of once-weekly semaglutide 0.5 mg and 1.0 mg versus dulaglutide 1.5 mg for the treatment of patients with type 2 diabetes uncontrolled on metformin in the Chinese setting.

Methods: The Swedish Institute of Health Economics Diabetes Cohort Model (IHE-DCM) was used to evaluate the long-term health and economic outcomes of once-weekly semaglutide and dulaglutide. Analysis was conducted from the perspective of the Chinese healthcare systems over a time horizon of 40 years. Data on baseline cohort characteristics and treatment effects were sourced from the SUSTAIN 7 clinical trial. Costs included treatment costs and costs of complications. Projected health and economic outcomes were discounted at a rate of 5% annually. The robustness of the results was evaluated through one-way sensitivity analyses and probabilistic sensitivity analyses.

Results: Compared with dulaglutide 1.5 mg, once-weekly semaglutide 0.5 mg and 1.0 mg were associated with improvements in discounted life expectancy of 0.04 and 0.10 years, respectively, and improvements in discounted quality-adjusted life expectancy of 0.08 and 0.19 quality-adjusted life years (QALYs), respectively. Clinical benefits were achieved at reduced costs, with lifetime cost savings of 8355 Chinese Yuan (CNY) with once-weekly semaglutide 0.5 mg and 11,553 CNY with once-weekly semaglutide 1.0 mg. Sensitivity analyses verified the robustness of the research results.

Conclusions: Once-weekly semaglutide was suggested to be dominant (more effective and less costly) versus dulaglutide 1.5 mg in patients with type 2 diabetes uncontrolled on metformin treatment in China.
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http://dx.doi.org/10.1007/s13300-022-01301-4DOI Listing
August 2022

A novel WRKY34-bZIP3 module regulates phenolic acid and tanshinone biosynthesis in Salvia miltiorrhiza.

Metab Eng 2022 Aug 4. Epub 2022 Aug 4.

Laboratory of Medicinal Plant Biotechnology, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, PR China. Electronic address:

Phenolic acids and tanshinones are main bioactive compounds produced in Salvia miltiorrhiza widely used in treatment of cardiovascular diseases, which could be promoted by abscisic acid elicitation. However, the regulation mechanism remained to be elucidated. An ABA-inducible IIa WRKY transcription factor (TF) named SmWRKY34 exhibiting high homology with AtWRKY40 was isolated. SmWRKY34 exhibited a negative role on phenolic acids and tanshinones by directly regulating SmRAS and SmGGPPS. Moreover, ABA-responsive bZIP TF member named SmbZIP3 expressed significantly in SmWRKY34 transcriptome was screened. SmWRKY34 has a negative regulatory role on SmbZIP3. SmbZIP3 acts as a positive regulator in the biosynthesis of phenolic acids and tanshinones by targeting SmTAT and two tanshinone-promoting TFs SmERF128 and SmMYB9b. Taken together, we identified a new module WRKY34-bZIP3 involved in ABA signaling that manipulates phenolic acid and tanshinone accumulation, shedding new insights in metabolic engineering application in S. miltiorrhiza.
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http://dx.doi.org/10.1016/j.ymben.2022.08.002DOI Listing
August 2022

Nonequilibrium work distributions in quantum impurity system-bath mixing processes.

J Chem Phys 2022 Aug;157(5):054109

Department of Chemical Physics, University of Science and Technology of China, Hefei, Anhui 230026, China.

The fluctuation theorem, where the central quantity is the work distribution, is an important characterization of nonequilibrium thermodynamics. In this work, based on the dissipaton-equation-of-motion theory, we develop an exact method to evaluate the work distributions in quantum impurity system-bath mixing processes in the presence of non-Markovian and strong couplings. Our results not only precisely reproduce the Jarzynski equality and Crooks relation but also reveal rich information on large deviation. The numerical demonstrations are carried out with a spin-boson model system.
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http://dx.doi.org/10.1063/5.0095549DOI Listing
August 2022

A new criterion to determine left bundle branch capture based on individualized His bundle or right ventricular septal pacing.

Heart Rhythm 2022 Aug 3. Epub 2022 Aug 3.

Department of Cardiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing, 210029, China. Electronic address:

Background: Left bundle branch pacing (LBBP) is an emerging physiological pacing modality. How to differentiate LBBP from left ventricular septal pacing (LVSP) remains challenging.

Objective: We aimed to develop a new personalized intra-operative criterion to confirm left bundle branch (LBB) capture in patients with or without heart failure (HF).

Methods: Patients were enrolled if surface 12-lead ECGs of LBBP, LVSP, temporary His bundle pacing (HBP) and right ventricular septal pacing (RVSP) were recorded during the procedure with the leads placed in basal midseptal region. Left ventricular activation time (LVAT) was measured during different pacing modalities. ΔLVAT1 was defined as the difference of LVAT between HBP and LBBP/LVSP. ΔLVAT2 was estimated by the difference of LVAT between RVSP and LBBP/LVSP. ΔLVAT1% and ΔLVAT2% were calculated as the percent reduction of ΔLVAT1 and ΔLVAT2 respectively.

Results: A total of 105 consecutive patients were included, among whom 80 had normal cardiac function (65 LBBP and 15 LVSP) and 25 had HF. Patients with LBBP showed significantly shorter LVAT than those with LVSP. In patients with normal cardiac function, a cut-off value of ΔLVAT1 > 12.5 ms showed 73.9% sensitivity and 93.3% specificity to confirm LBB capture. In patients with HF, a cut-off value of ΔLVAT1% > 9.8% exhibited great accuracy for LBB capture (sensitivity 92.0% and specificity 92.3%). The optimal value of ΔLVAT2% for differentiating LBBP from LVSP was 21.2%.

Conclusion: Temporary HBP and RVSP can serve as references to confirm LBB capture in an individualized fashion in patients with or without HF.
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http://dx.doi.org/10.1016/j.hrthm.2022.07.022DOI Listing
August 2022

Study of the Mechanism of Antiemetic Effect of Mill. Essential Oil Based on Ca/CaMKII/ERK1/2 Pathway.

Drug Des Devel Ther 2022 26;16:2407-2422. Epub 2022 Jul 26.

Department of Pharmaceutics, The Key Laboratory of Basic and New Drug Research of Traditional Chinese Medicine, Shaanxi University of Chinese Medicine, Xianyang, People's Republic of China.

Purpose: To investigate the effective components and possible mechanism of action of Mill. essential oil (LEO) in preventing vomiting through the olfactory pathway.

Materials And Methods: A new network pharmacology-based method was established to analyze main components and pathways of LEO involved in antiemetic effects by introducing component content; biological activities of key proteins of the olfactory pathway and their corresponding compounds were verified by molecular docking technique; and finally pica in a rat model was established to verify the molecular mechanism of antiemetic effects of LEO by enzyme-linked immunosorbent assay (ELISA) to determine the serum 5-HT, substance P, and DA levels in each group and by immunohistochemistry to determine the contents of 5-HTR, CaMKII and ERK1/2 proteins in the medulla oblongata tissue.

Results: Network pharmacology combined with molecular docking analysis showed that the mechanism of the antiemetic effect of LEO may be related to (2Z)-3,7-dimethyl-2,6-octadienyl acetate, linalyl acetate, butanoic acid, hexyl ester, 4-hexen-1-ol, 5-methyl-2-(1-methylethenyl)-, acetate, .tau.-cadinol and other active ingredients, which regulate the cyclic adenosine monophosphate (cAMP) signaling pathway and the expression of BRAF, PDE and other targets on the pathway. An ELISA revealed that LEO reduced the levels of 5-hydroxytryptamine (5-HT), substance P, and dopamine in serum compared with the model group (P <0.05). Immunohistochemical analysis showed that LEO decreased the expression of 5-HTR, CaMKII, and ERK1/2 proteins in the medulla oblongata of rats compared with the model group (P <0.01).

Conclusion: LEO may achieve the antiemetic effect by reducing the content of 5-HT and inhibiting its related receptors, thereby regulating downstream Ca/CaMKII/ERK1/2 pathway of the cAMP signaling pathway.
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http://dx.doi.org/10.2147/DDDT.S366597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9341382PMC
August 2022

Bioinformatics Analysis Identifies Potential Related Genes in the Pathogenesis of Intrauterine Fetal Growth Retardation.

Evol Bioinform Online 2022 28;18:11769343221112780. Epub 2022 Jul 28.

Department of Anesthesiology, Sichuan Cancer Center, Sichuan Cancer Hospital & Institute, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Background: Intrauterine growth retardation (IUGR) affects approximately 10% to 15% of all pregnancies worldwide. IUGR is not only associated with stillbirth and newborn death, but also the delay of cognition in childhood and the promotion of metabolic and vascular disorders in adulthood. Figuring out the mechanism of IUGR is rather meaningful and valuable.

Methods: Datasets related to IUGR were searched in the Gene Expression Omnibus website. Principal component analysis (PCA) was used for normalization. Differential expressed genes (DEGs) were screened out using the ggpot2 tool. DEGs were used to conduct Gene Ontology (GO) terms, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enrichment analyses, and protein-protein interaction (PPI) analysis. IUGR related genes were searched in the OMIM website to look for the intersection with the DEGs. The DEGs were analyzed for tissue-specific expression by the online resource BioGPS. The results were displayed through volcano map, Venn map, box plot, heat map, and GSEA enrichment plots drawn by R language packages.

Results: Eleven DEGs were screened out of 2 datasets. One hundred ninety-five genes related to IUGR in OMIM were retrieved. EGR2 was the only intersection gene that was found in both groups. Genes associated with placental tissue expression include COL17A1, HSD11B1, and LGALS14. Molecular functions of the DEGs are related to the oxidoreductase activity. The following 4 signaling pathways, reactome signaling by interleukins, reactome collagen degradation, Naba secreted factors, and PID NFAT tfpathway, were enriched by GSEA. Two critical modules comprising 5 up-regulated genes (LEP, PRL, TAC3, MMP14, and ADAMTS4) and 4 down-regulated genes (TIMP4, FOS, CCK, and KISS1) were identified by PPI analysis. Finally, we identified 6 genes (PRL, LGALS14, EGR2, TAC3, LEP, and KISS1) that are potentially relevant to the pathophysiology of IUGR.

Conclusion: The candidate down-regulated genes LGALS14 and KISS1, as well as the up-regulated genes PRL, EGR2, TAC3, and LEP, were found to be closely related to IUGR by bioinformatics analysis. These hub genes are related to hypoxia and oxidoreductase activities in placental development. We provide useful and novel information to explore the potential mechanism of IUGR and make efforts to the prevention of IUGR.
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http://dx.doi.org/10.1177/11769343221112780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340335PMC
July 2022

SIRT3 inhibitor 3-TYP exacerbates thioacetamide-induced hepatic injury in mice.

Front Physiol 2022 18;13:915193. Epub 2022 Jul 18.

Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, China.

The purpose of the study was to explore the effects of SIRT3 inhibitor 3-TYP on acute liver failure (ALF) in mice and its underlying mechanism. The mice were treated with thioacetamide (TAA, 300 mg/kg) for inducing ALF model. 3-TYP (50 mg/kg) was administered 2 h prior to TAA. The liver histological changes were measured by HE staining. Blood samples were collected for analysis of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). MDA and GSH were used to evaluate the oxidative stress of liver. The expression levels of inflammatory cytokines (TNF-α and IL-1β) were measured by ELISA and Western blotting. The cell type expression of IL-1β in liver tissue was detected by immunofluorescent staining. The expression of SIRT3, MnSOD, ALDH2, MAPK, NF-κB, Nrf2/HO-1, p-elF2α/CHOP, and cleaved caspase 3 was determined by Western blotting. TUNEL staining was performed to detect the apoptosis cells of liver tissues. 3-TYP exacerbated the liver injury of ALF mice. 3-TYP increased the inflammatory responses and activation of MAPK and NF-κB pathways. In addition, 3-TYP administration enhanced the damage of oxidative stress, endoplasmic reticulum stress, and promoted hepatocyte apoptosis in ALF mice. 3-TYP exacerbates thioacetamide-induced hepatic injury in mice. Activation of SIRT3 could be a promising target for the treatment of ALF.
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http://dx.doi.org/10.3389/fphys.2022.915193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340259PMC
July 2022

A statistical quasi-particles thermofield theory with Gaussian environments: System-bath entanglement theorem for nonequilibrium correlation functions.

J Chem Phys 2022 Jul;157(4):044102

Department of Chemical Physics, University of Science and Technology of China, Hefei, Anhui 230026, China.

For open quantum systems, the Gaussian environmental dissipative effect can be represented by statistical quasi-particles, namely, dissipatons. We exploit this fact to establish the dissipaton thermofield theory. The resulting generalized Langevin dynamics of absorptive and emissive thermofield operators are effectively noise-resolved. The system-bath entanglement theorem is then readily followed between an important class of nonequilibrium steady-state correlation functions. All these relations are validated numerically. A simple corollary is the transport current expression, which exactly recovers the result obtained from the nonequilibrium Green's function formalism.
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http://dx.doi.org/10.1063/5.0094875DOI Listing
July 2022

Choroidal metastasis resembling hemangioma on angiogram as initial manifestation of lung adenocarcinoma.

Int J Ophthalmol 2022 18;15(7):1203-1206. Epub 2022 Jul 18.

Eye Center of the 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, Zhejiang Province, China.

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http://dx.doi.org/10.18240/ijo.2022.07.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318081PMC
July 2022

A method using deep learning to discover new predictors from left-ventricular mechanical dyssynchrony for CRT response.

J Nucl Cardiol 2022 Aug 1. Epub 2022 Aug 1.

College of Computing, Michigan Technological University, 1400 Townsend Drive, Houghton, MI, USA.

Background: Studies have shown that the conventional parameters characterizing left ventricular mechanical dyssynchrony (LVMD) measured on gated SPECT myocardial perfusion imaging (MPI) have their own statistical limitations in predicting cardiac resynchronization therapy (CRT) response. The purpose of this study is to discover new predictors from the polarmaps of LVMD by deep learning to help select heart failure patients with a high likelihood of response to CRT.

Methods: One hundred and fifty-seven patients who underwent rest gated SPECT MPI were enrolled in this study. CRT response was defined as an increase in left ventricular ejection fraction (LVEF) > 5% at 6 [Formula: see text] 1 month follow up. The autoencoder (AE) technique, an unsupervised deep learning method, was applied to the polarmaps of LVMD to extract new predictors characterizing LVMD. Pearson correlation analysis was used to explain the relationships between new predictors and existing clinical parameters. Patients from the IAEA VISION-CRT trial were used for an external validation. Heatmaps were used to interpret the AE-extracted feature.

Results: Complete data were obtained in 130 patients, and 68.5% of them were classified as CRT responders. After variable selection by feature importance ranking and correlation analysis, one AE-extracted LVMD predictor was included in the statistical analysis. This new AE-extracted LVMD predictor showed statistical significance in the univariate (OR 2.00, P = .026) and multivariate (OR 1.11, P = .021) analyses, respectively. Moreover, the new AE-extracted LVMD predictor not only had incremental value over PBW and significant clinical variables, including QRS duration and left ventricular end-systolic volume (AUC 0.74 vs 0.72, LH 7.33, P = .007), but also showed encouraging predictive value in the 165 patients from the IAEA VISION-CRT trial (P < .1). The heatmaps for calculation of the AE-extracted predictor showed higher weights on the anterior, lateral, and inferior myocardial walls, which are recommended as LV pacing sites in clinical practice.

Conclusions: AE techniques have significant value in the discovery of new clinical predictors. The new AE-extracted LVMD predictor extracted from the baseline gated SPECT MPI has the potential to improve the prediction of CRT response.
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http://dx.doi.org/10.1007/s12350-022-03067-5DOI Listing
August 2022

Bound vortex light in an emulated topological defect in photonic lattices.

Light Sci Appl 2022 Aug 1;11(1):243. Epub 2022 Aug 1.

National Laboratory of Solid State Microstructures and School of Physics, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing, Jiangsu, 210093, China.

Topology have prevailed in a variety of branches of physics. And topological defects in cosmology are speculated akin to dislocation or disclination in solids or liquid crystals. With the development of classical and quantum simulation, such speculative topological defects are well-emulated in a variety of condensed matter systems. Especially, the underlying theoretical foundations can be extensively applied to realize novel optical applications. Here, with the aid of transformation optics, we experimentally demonstrated bound vortex light on optical chips by simulating gauge fields of topological linear defects in cosmology through position-dependent coupling coefficients in a deformed photonic graphene. Furthermore, these types of photonic lattices inspired by topological linear defects can simultaneously generate and transport optical vortices, and even can control the orbital angular momentum of photons on integrated optical chips.
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http://dx.doi.org/10.1038/s41377-022-00931-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343378PMC
August 2022

Cost-Effectiveness Analysis of Dapagliflozin Plus Standard Treatment for Patients With Type 2 Diabetes and High Risk of Cardiovascular Disease in China.

Front Public Health 2022 13;10:936703. Epub 2022 Jul 13.

Key Laboratory of Anti-inflammatory and Immunopharmacology, Department of Clinical Pharmacy, Ministry of Education, Anhui Medical University, Hefei, China.

Purpose: To evaluate the long-term cost-effectiveness of dapagliflozin, in addition to standard treatment, for the treatment of adult patients with type 2 diabetes (T2DM) at high cardiovascular risk from the Chinese healthcare system perspective.

Methods: A decision-analytic Markov model with one-year cycles was developed to evaluate the health and economic outcomes in patients with T2DM and high risk of cardiovascular disease (CVD) treated with standard treatment and dapagliflozin plus standard treatment for 30 years. Clinical data, cost, and utility data were extracted from databases or published literature. Quality-adjusted life-years (QALYs), costs (€/¥ 2021) as well as incremental cost-effectiveness ratios (ICERs) were calculated. Deterministic and probabilistic sensitivity analyses were performed to assess the uncertainty in the results.

Results: Compared with standard treatment, dapagliflozin plus standard treatment was predicted to result in an additional 0.25 QALYs (12.26 QALYs vs. 12.01 QALYs) at an incremental cost of €4,435.81 (¥33,875.83) per patient. The ICER for dapagliflozin plus standard treatment vs. standard treatment was €17,742.07 (¥135,494.41) per QALY gained, which was considered cost-effective in China compared to three times the GDP per capita in 2021 (€31,809.77/¥242,928). The deterministic and probabilistic sensitivity analyses showed the base-case results to be robust.

Conclusions: The study suggests that, from the perspective of the Chinese health system, dapagliflozin plus standard treatment is a cost-effective option for patients with T2DM at high cardiovascular risk. These findings may help clinicians make the best treatment decisions for patients with T2DM at high cardiovascular risk.
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http://dx.doi.org/10.3389/fpubh.2022.936703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326075PMC
August 2022

Analysis of Interventional Application Effect of Ultrasound-Guided QLB and TAPB in the Treatment and Analgesia of Patients Undergoing Laparoscopic Colorectal Surgery.

Contrast Media Mol Imaging 2022 14;2022:4199868. Epub 2022 Jul 14.

Ultrasound Imaging Department of Lishui City People's Hospital, Lishui 323000, China.

Colorectal cancer is a common malignant tumor of the digestive system. In order to study the clinical efficacy of ultrasound-guided QLB and TAPB in the treatment and postoperative analgesia of patients undergoing laparoscopic colorectal surgery. A total of 96 patients undergoing laparoscopic colorectal surgery from January 2021 to January 2022 are selected as the study subjects. The results show that ultrasound-guided QLB and TAPB therapy have good analgesic effects in patients undergoing laparoscopic colorectal surgery, and QLB treatment and postoperative analgesic effect are better than TAPB.
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http://dx.doi.org/10.1155/2022/4199868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303504PMC
August 2022

Pedicle subtraction osteotomy for the corrective surgery of ankylosing spondylitis with thoracolumbar kyphosis: experience with 38 patients.

BMC Musculoskelet Disord 2022 Jul 30;23(1):731. Epub 2022 Jul 30.

Department of Spine Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, Xinjiang, China.

Objective: To evaluate the sagittal parameters and clinical outcome of pedicle subtraction osteotomy (PSO) for the treatment of ankylosing spondylitis (AS) combined with thoracolumbar kyphosis.

Methods: The clinical data of 38 patients with AS combined with thoracolumbar kyphosis who underwent PSO were enrolled and divided into the lumbar lordosis group and the lumbar kyphosis group according to the preoperative sagittal morphology. They were subdivided into the lumbar lordosis T12 group, lordosis L1 group, kyphosis L2 group, and kyphosis L3 group. The spine sagittal parameters were compared between the preoperative and the postoperative. Outcome evaluation was performed by the Japanese Orthopedic Association (JOA) score, visual analogue scale (VAS), and the Oswestry Disability Index (ODI).

Results: A total of 38 patients with AS combined with thoracolumbar kyphosis were successfully treated by PSO, with a mean follow-up time of 26.9 ± 11.9 months. There were 30 males and 8 females with a mean age of 41.6 ± 7.1 years. Twenty patients consisted in the lumbar lordosis group and 18 patients in the lumbar kyphosis group. GK, SVA, and CBVA were improved significantly (P < 0.05) at the final follow-up between the lumbar lordosis T12 group and the L1 group. Patients in the lumbar kyphosis L2 group and L3 group all received satisfactory, including LL, GK, and SVA (P < 0.05). There was no statistically significant difference in the preoperative TK, GK, SVA, PT, and PI between the lumbar lordosis and lumbar kyphosis groups (P > 0.05). Postoperative complications occurred in three cases.

Conclusion: PSO was a practical method for the treatment of patients with AS combined with thoracolumbar kyphosis. PSO at L3 was recommended to be selected for the lumbar kyphosis to obtain greater SVA correction. CBVA of single-segment PSO may be significantly lower than the two-segment PSO in the management of patients with kyphosis of lower CBVA.
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http://dx.doi.org/10.1186/s12891-022-05693-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338567PMC
July 2022

CC chemokine receptor 7 promotes macrophage recruitment and induces M2-polarization through CC chemokine ligand 19&21 in oral squamous cell carcinoma.

Discov Oncol 2022 Jul 29;13(1):67. Epub 2022 Jul 29.

Department of Oral Maxillofacial-Head and Neck Surgery, School of Stomatology, China Medical University, Oral Diseases Laboratory of Liaoning, 117 Nanjing North Road, Heping District, Shenyang, 110000, Liaoning, China.

Purpose: This study aimed to investigate the impact of CC chemokine receptor 7 (CCR7) on the recruitment and polarization of tumor-associated macrophages (TAMs) in oral squamous cell carcinoma (OSCC).

Methods: We analyzed CCR7 expression pattern, clinicopathological significance, and its association with M2 macrophage infiltration in OSCC by bioinformatic methods. Small interfering RNA (siRNA) was utilized to silence CCR7 in OSCC cells. Conditioned media (CM) was harvested from transfected OSCC cells to establish a co-culture model of THP-1 derived macrophages and OSCC cells. Transwell assay and cell adhesion assay were performed to examine the effect of CCR7 on macrophages recruitment and adhesion. Cytoskeleton was labelled by phalloidin to observe macrophage morphological changes. Moreover, phenotypic alteration of macrophages was measured using quantitative real-time PCR (qRT-PCR), flow cytometry, and immunofluorescence (IF) staining. Ultimately, recombinant human CCL19 and CCL21 were added into the medium of THP-1 derived macrophages to explore their effects on polarization in vitro.

Results: In OSCC patients, the overexpression of CCR7 positively correlated with lymph node metastasis and M2 macrophage infiltration. Macrophage not only exhibited enhanced migration, invasion and adhesion abilities, but also appeared more spindle and branched in vitro when treated with CM from OSCC cells. However, these phenomena were abrogated with knockdown of CCR7. We also discovered that inhibition of CCR7 in OSCC cells suppressed TAMs polarization to an M2 phenotype. In addition, recombinant human CCL19 and CCL21 promoted macrophage M2-polarization in vitro.

Conclusion: CCR7 in OSCC cells promoted recruitment and M2-polarization of THP-1 derived macrophages in vitro by regulating production of CCL19 and CCL21.
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http://dx.doi.org/10.1007/s12672-022-00533-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338204PMC
July 2022

The Origin and Evolution of Bladder Cancer Stem Cells.

Front Cell Dev Biol 2022 12;10:950241. Epub 2022 Jul 12.

2nd Inpatient Area of Urology Department, China-Japan Union Hospital of Jilin University, Changchun, China.

Bladder cancer is the most common malignant tumor of the urinary system. Bladder cancer stem cells (BCSCs) play key roles in tumor initiation, metastasis, relapse and drug-resistance. Investigation of BCSCs is of great value. On the basis of a review of normal bladder stem cells and universal cancer stem cells (CSCs), we summarize the origin of BCSCs, isolation and identification of CSCs from bladder cancer, signaling pathway of BCSCs, BCSCs targeted therapy, and relationship of BCSCs with non-muscle invasiveness and muscle invasiveness. This review aims to provide better elucidation about BCSCs, and provide constructive data for classification, prognosis, treatment and early intervention of bladder cancer.
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http://dx.doi.org/10.3389/fcell.2022.950241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314767PMC
July 2022

Optimization Strategies of Electrolytes for Low-temperature Aqueous Batteries.

Chem Rec 2022 Jul 27:e202200132. Epub 2022 Jul 27.

Songshan Lake Materials Laboratory, Dongguan, 523808, China.

Aqueous rechargeable batteries (ARBs) are considered promising electrochemical energy storage systems for grid-scale applications due to their low cost, high safety, and environmental benignity. With the demand for a wide range of application scenarios, batteries are required to work in various harsh conditions, especially the cold weather. Nevertheless, electrolytes would freeze at extremely low temperatures, resulting in dramatically sluggish kinetics and severe performance degradation. Here, we discuss the behaviors of hydrogen bonds and basic principles of anti-freezing mechanisms in aqueous electrolytes. Then, we present a systematical review of the optimization strategies of electrolytes for low-temperature aqueous batteries. Finally, the challenges and promising routes for further development of aqueous low-temperature electrolytes are provided. This review can serve as a comprehensive reference to boost the further development and practical applications of advanced ARBs operated at low temperatures.
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http://dx.doi.org/10.1002/tcr.202200132DOI Listing
July 2022

Engineering monodispersed 2 nm SbS particles embedded in a porphyrin-based MOF-derived mesoporous carbon network an adsorption method to construct a high-performance sodium-ion battery anode.

Dalton Trans 2022 Jul 27. Epub 2022 Jul 27.

Department of Chemistry, Northeastern University, Shenyang 110819, People's Republic of China.

Sodium ion batteries (SIBs) are expected to replace lithium ion batteries (LIBs) as the next generation of large-scale energy storage applications because of their superior cost performance. However, the larger ionic radius of Na causes a remarkable volume expansion than that of Li during charge and discharge, which reduces the performance of the battery. In this work, we engineered a composite material in that monodispersed 2 nm SbS particles are uniformly loaded into a carbon matrix (SbS/CZM), which is obtained by carbonization of a zirconium-based MOF with adsorption of Sb. The obtained composite material has a high specific surface area in favor of mass transfer, and the porous structure can resist many volume changes in the circulation process. Moreover, the ultrafine SbS particles are well-distributed in the composite material, which increases the utilization of the active substance and is promising for the storage of Na. Based on its unique structure, the SbS/CZM composite shows a specific capacity of 550 mA h g at 100 mA g and an excellent cycling stability of 88.9% retention after 1000 cycles at 3 A g. The excellent electrochemical performance provides enlightenment for the rational design of hierarchical heterostructures for energy storage applications.
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http://dx.doi.org/10.1039/d2dt01898eDOI Listing
July 2022

A Mean-Field Game Control for Large-Scale Swarm Formation Flight in Dense Environments.

Sensors (Basel) 2022 Jul 21;22(14). Epub 2022 Jul 21.

School of Mathematical Sciences, Beihang University, Beijing 100191, China.

As an important part of cyberphysical systems (CPSs), multiple aerial drone systems are widely used in various scenarios, and research scenarios are becoming increasingly complex. However, planning strategies for the formation flying of aerial swarms in dense environments typically lack the capability of large-scale breakthrough because the amount of communication and computation required for swarm control grows exponentially with scale. To address this deficiency, we present a mean-field game (MFG) control-based method that ensures collision-free trajectory generation for the formation flight of a large-scale swarm. In this paper, two types of differentiable mean-field terms are proposed to quantify the overall similarity distance between large-scale 3-D formations and the potential energy value of dense 3-D obstacles, respectively. We then formulate these two terms into a mean-field game control framework, which minimizes energy cost, formation similarity error, and collision penalty under the dynamical constraints, so as to achieve spatiotemporal planning for the desired trajectory. The classical task of a distributed large-scale aerial swarm system is simulated by numerical examples, and the feasibility and effectiveness of our method are verified and analyzed. The comparison with baseline methods shows the advanced nature of our method.
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http://dx.doi.org/10.3390/s22145437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320791PMC
July 2022

Maleimide-Functionalized Liposomes: Prolonged Retention and Enhanced Efficacy of Doxorubicin in Breast Cancer with Low Systemic Toxicity.

Molecules 2022 Jul 20;27(14). Epub 2022 Jul 20.

Key Laboratory of Coarse Cereal Processing, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China.

Cell surface thiols can be targeted by thiol-reactive groups of various materials such as peptides, nanoparticles, and polymers. Here, we used the maleimide group, which can rapidly and covalently conjugate with thiol groups, to prepare surface-modified liposomes (M-Lip) that prolong retention of doxorubicin (Dox) at tumor sites, enhancing its efficacy. Surface modification with the maleimide moiety had no effect on the drug loading efficiency or drug release properties. Compared to unmodified Lip/Dox, M-Lip/Dox was retained longer at the tumor site, it was taken up by 4T1 cells to a significantly greater extent, and exhibited stronger inhibitory effect against 4T1 cells. The in vivo imaging results showed that the retention time of M-Lip at the tumor was significantly longer than that of Lip. In addition, M-Lip/Dox also showed significantly higher anticancer efficacy and lower cardiotoxicity than Lip/Dox in mice bearing 4T1 tumor xenografts. Thus, the modification strategy with maleimide may be useful for achieving higher efficient liposome for tumor therapy.
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http://dx.doi.org/10.3390/molecules27144632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320254PMC
July 2022

Excellent Photonic and Mechanical Properties of Macromorphic Fibers Formed by Eu-Complex-Anchored, Unzipped, Multiwalled Carbon Nanotubes.

Materials (Basel) 2022 Jul 15;15(14). Epub 2022 Jul 15.

Institute of Hybrid Materials, National Centre of International Joint Research for Hybrid Materials Technology, National Base of International Science & Technology Cooperation on Hybrid Materials, Qingdao University, 308 Ningxia Road, Qingdao 266071, China.

The macromorphic properties of carbon nanotubes perform poorly because of their size limitations: nanosize in diameters and microsize in length. In this work, to realize these dual purposes, we first used an electrochemical method to tear the surface of multiwalled carbon nanotubes (MWCNTs) to anchor photonic Eu-complexes there. Through the polar reactive groups endowed by the tearing, the Eu-complexes coordinate at the defected structures, obtaining the Eu-complex-anchored, unzipped, multiwalled carbon nanotubes (E-uMWCNTs). The controllable surface-breaking retains the MWCNTs' original, excellent mechanical properties. Then, to obtain the macromorphic structure with infinitely long fibers, a wet-spinning process was applied via the binding of a small quantity of polyvinyl alcohol (PVA). Thus, the wet-spun fibers with high contents of E-uMWCNTs (E-uMWCNT-Fs) were produced, in which the E-uMWCNTs took 33.3 wt%, a high ratio in E-uMWCNT-Fs. On the other hand, due to the reinforcing effect of E-uMWCNTs, the highest tensile strength can reach 228.2 MPa for E-uMWCNT-Fs. Meanwhile, the E-uMWCNT-Fs show high-efficiency photoluminescence and excellent media resistance performance due to the embedding effect of PVA on the E-uMWCNTs. Therefore, E-uMWCNT-Fs can exhibit excellent luminescence properties in aqueous solutions at pH 4~12 and in some high-concentration metal-ion solutions. Those distinguished performances promise outstanding innovations of this work.
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http://dx.doi.org/10.3390/ma15144933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320603PMC
July 2022

Morphological and Phylogenetic Characterization Reveals Five New Species of (Cordycipitaceae, Hypocreales).

J Fungi (Basel) 2022 Jul 19;8(7). Epub 2022 Jul 19.

Yunnan Herbal Laboratory, College of Ecology and Environmental Sciences, Yunnan University, Kunming 650091, China.

is a very important fungal resource, with some species in the genus having great medical, economic and ecological value. This study reports five new species of from Yunnan Province and Guizhou Province in Southwestern China and Dole Province in Vietnam, providing morphological descriptions, illustrations, phylogenetic placements, associated hosts and comparisons with allied taxa. Based on morphological observations and phylogenetic analyses of combined nr, nr, , and sequence data, it was determined that these five new species were located in the clade of and different from other species of . The five novel species had morphologies similar to those of other species in the genus, with bright orange cylindrical to clavate stromata (gregarious). The fertile part lateral sides usually had a longitudinal ditch without producing perithecia, and superficial perithecia. The phialides had a swollen basal portion, tapering abruptly into a narrow neck and oval or fusiform one-celled conidia, often in chains. The morphological characteristics of 23 species in , including five novel species and 18 known taxa, were also compared in the present study.
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http://dx.doi.org/10.3390/jof8070747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321185PMC
July 2022

Diagnostic Process and Barriers Among Chinese-American and Korean-American Parents of Children with Autism.

J Dev Behav Pediatr 2022 Aug 3;43(6):327-334. Epub 2022 Mar 3.

Developmental-Behavioral Pediatrics, University of Maryland, Baltimore, MD.

Objective: We sought to understand the experiences of Chinese-American and Korean-American parents of children with autism, including their initial concerns regarding their child's development, reported health professionals' responses to these concerns, diagnostic barriers, and factors associated with early autism diagnosis.

Method: We designed a survey with support from an expert advisory group and Asian-American parents of children with autism. We measured 3 time points of diagnostic history, areas of parents' concerns, professionals' responses to their concerns, 15 types of diagnostic barriers, and professionals' helpfulness. We used descriptive and independent t tests to analyze data from 28 parents of children with autism.

Results: Most of the parents (86%) had early concerns about their children's developmental delays and expressed their concerns to health professionals. However, approximately 60% of the parents reported that the professionals did not conduct developmental screenings or make referrals to specialists. The most common diagnostic barrier was the stress of the diagnostic process, followed by navigating health care systems. Parents who required interpreters noted poor quality and unavailability. Early child developmental concerns were associated with early autism diagnoses.

Conclusion: Although many Chinese-American and Korean-American parents had early concerns regarding their child's development and shared their concerns with health care professionals, parents encountered many barriers, including the stress of the diagnostic process. Chinese-American and Korean-American parents with limited English proficiency required additional support. Health care professionals' active listening and responses to parents' concerns can promote early diagnosis.
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http://dx.doi.org/10.1097/DBP.0000000000001070DOI Listing
August 2022

Value of contrast-enhanced ultrasound in diagnosis and differential diagnosis of polypoid lesions of gallbladder ≥ 1 cm.

BMC Gastroenterol 2022 Jul 25;22(1):354. Epub 2022 Jul 25.

Department of Ultrasound, Shengjing Hospital of China Medical University, Sanhao Street No. 36, Heping District, Shenyang, 110004, Liaoning Province, China.

Objectives: To evaluate the usefulness of Contrast-enhanced ultrasound (CEUS) in the diagnosis and differential diagnosis of Polypoid lesions of gallbladder (PLGs) ≥ 1 cm.

Methods: A prospective analysis was performed on 180 patients with PLGs ≥ 1 cm. 175 cases were confirmed by pathological diagnosis and the remaining were confirmed by other imaging findings. The characteristics of lesions on conventional Ultrasonography (US) and CEUS were recorded.

Results: Significant differences were observed in enhancement patterns between benign and malignant PLGs during both arterial (P < 0.001) and venous phases (P < 0.001). The malignant lesions typically yielded a "fast-in and fast-out" enhancement pattern. There was no significant difference in Arrival time (AT) between malignant and benign PLGs. If we consider wash-out time ≤ 40 s as a diagnostic standard for malignant lesions, the sensitivity, specificity, and accuracy were 88.24%, 85.62%, and 86.11%, respectively. Destruction of the Gallbladder (GB) wall was a particularly important indication of malignant PLGs, and the sensitivity, specificity, and accuracy were 93.33%, 92.12%, and 92.22%, respectively. The accuracy of CEUS in the diagnosis of PLGs, as well as malignant and benign lesions, was 92.22%, 92.47%, and 91.17%, respectively.

Conclusions: The "fast-in and fast-out" enhancement pattern, hyper-enhancement in comparison to the GB wall in the arterial phase, wash-out time ≤ 40 s, GB wall destruction, and hepatic parenchymal infiltration are the characteristic findings of malignant PLGs. Besides, CEUS provides a valuable reference to classify some of the benign lesions.
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http://dx.doi.org/10.1186/s12876-022-02373-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316436PMC
July 2022

Denitrification Performance in Packed-Bed Reactors Using Novel Carbon-Sulfur-Based Composite Filters for Treatment of Synthetic Wastewater and Anaerobic Ammonia Oxidation Effluent.

Front Microbiol 2022 7;13:934441. Epub 2022 Jul 7.

Institute of Process Equipment and Environmental Engineering, School of Mechanical Engineering and Automation, Northeastern University, Shenyang, China.

To avoid nitrate pollution in water bodies, two low-cost and abundant natural organic carbon sources were added to make up the solid-phase denitrification filters. This study compared four novel solid-phase carbon-sulfur-based composite filters, and their denitrification abilities were investigated in laboratory-scale bioreactors. The filter F (mixture of elemental sulfur powder, shell powder, and peanut hull powder with a mass ratio of 6:2.5:1.5) achieved the highest denitrification ability, with an optimal nitrate removal rate (NRR) of 723 ± 14.2 mg NO -N⋅L⋅d when the hydraulic retention time (HRT) was 1 h. The HRT considerably impacted effluent quality after coupling of anaerobic ammonium oxidation (ANAMMOX) and solid-phase-based mixotrophic denitrification process (SMDP). The concentration of suspended solids (SS) of the ANAMMOX effluent may affect the performance of the coupled system. Autotrophs and heterotrophs were abundant and co-existed in all reactors; over time, the abundance of heterotrophs decreased while that of autotrophs increased. Overall, the SMDP process showed good denitrification performance and reduced the sulfate productivity in effluent compared to the sulfur-based autotrophic denitrification (SAD) process.
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http://dx.doi.org/10.3389/fmicb.2022.934441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301263PMC
July 2022
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