Publications by authors named "Yanying He"

7 Publications

  • Page 1 of 1

One-pot synthesis of oxygen-vacancy-rich Cu-doped UiO-66 for collaborative adsorption and photocatalytic degradation of ciprofloxacin.

Sci Total Environ 2021 Nov 27:151962. Epub 2021 Nov 27.

Key Laboratory of Water-Sediment Sciences and Water Disaster Prevention of Hunan Province, School of Hydraulic Engineering, Changsha University of Science & Technology, Changsha 410004, PR China.

UiO-66, as one of the most stable metal-organic frameworks (MOFs), has attracted a lot of attention in the field of adsorption and photocatalysis. However, this application of UiO-66 is still limited due to either the low accessibility of micropores or the poor electron-hole charge separation capability. This study aims to promote UiO-66 accessibility of micropores and charge separation through the construction of oxygen vacancies (OVs) and mesopore defects as well as copper incorporation. Herein, mesopore Cu doped UiO-66 with rich OVs was synthesized by a one-pot method and demonstrated high efficiency for the removal of ciprofloxacin (CIP) from the aquatic system. First of all, denatured mesopore defects were produced in Cu doped UiO-66 which possessed a 58% increase in specific surface area compared to UiO-66, facilitating the adsorption of molecular oxygen. Secondly, e was preferentially trapped by OVs under light irradiation. Electron (e) reacted rapidly with the surface adsorbed oxygen to generate superoxide radical (O). Meanwhile, copper incorporation increased the photocurrent and reduced the interfacial charge transfer resistance, thereby improving the charge separation efficiency. As a result, the adsorption efficiency and photocatalytic performance of mesopore Cu doped UiO-66 with OVs were 8.1 and 3.7 times higher than those of UiO-66, respectively. This study paved a way for the one-step synthesis of MOFs containing OVs and broadened the possibilities of practical applications for photo-induced removal of antibiotics from effluent.
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http://dx.doi.org/10.1016/j.scitotenv.2021.151962DOI Listing
November 2021

Photocatalytic degradation of tetracycline by metal-organic frameworks modified with BiWO nanosheet under direct sunlight.

Chemosphere 2021 Dec 1;284:131386. Epub 2021 Jul 1.

Key Laboratory of Water-Sediment Sciences and Water Disaster Prevention of Hunan Province, School of Hydraulic Engineering, Changsha University of Science & Technology, Changsha, 410004, PR China.

Porous metal-organic frameworks (MOFs) with visible-light response have attracted much attention in the field of environmental purification and solar energy conversion. In this study, MIL-100(Fe) was modified with BiWO nanosheets by a facile hydrothermal method to fabricate a photocatalyst with direct Z-scheme heterojunction. When treating the tetracycline (TC) solution under natural sunlight, 12 wt%MIL-100(Fe)/BiWO obtained the highest apparent rate constant of (6.59 ± 0.52)✕10 L mg min, which was 16.1 and 3.9 times than that of pristine MIL-100(Fe) and BiWO, respectively. In addition to explore the feasibility of sunlight-activated MIL-100(Fe)/BiWO to remove TC under various conditions, the degradation intermediates and their possible transformation pathway were provided with the aid of three-dimensional excitation-emission matrix spectra and liquid chromatography-mass spectrometry system. The results of Escherichia coli culture demonstrated that the biotoxicity variation of TC solution would first increase and then decrease with the photodegradation time. Ultimately, based on the results of bandgap calculation, radicals trapping and charge flow tracking experiments, the direct Z-scheme heterojunction between MIL-100(Fe) and BiWO nanosheets was confirmed and the photocatalytic mechanism for TC degradation was rationally proposed. This work enriched MOFs-based heterojunction photocatalysts and provided a promising method to eliminate hazardous TC from aqueous solution.
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http://dx.doi.org/10.1016/j.chemosphere.2021.131386DOI Listing
December 2021

Modified MIL-100(Fe) for enhanced photocatalytic degradation of tetracycline under visible-light irradiation.

J Colloid Interface Sci 2020 Aug 20;574:364-376. Epub 2020 Apr 20.

Hunan Provincial Center for Ecological and Environmental Affairs, Changsha 410014, PR China.

Iron-based metal-organic frameworks (MOFs) with low cost and excellent photocatalytic potential are extremely attractive in the field of energy utilization and environmental remediation. In this study, a novel InS/MIL-100(Fe) photocatalyst was successfully synthesized by a facile solvothermal method for the first time. Several technologies (such as X-ray diffraction, scanning electron microscope, transmission electron microscope, and X-ray photoelectron spectroscopy) were used to characterize the as-obtained samples and demonstrate the successful combination of MIL-100(Fe) and InS. Experimental results showed that 18% of tetracycline (TC) was adsorbed under dark condition and another 70% of TC was degraded under visible-light irradiation when treating 100 mL of TC solution (10 mg/L) with 30 mg of InS/MIL-100(Fe) composites. The corresponding TC removal efficiency was almost 1.9 and 1.6 times higher than that of pure MIL-100(Fe) and InS, respectively. The mechanism investigations revealed that the heterojunction composite exhibited superior charge transfer than either MIL-100(Fe) or InS, and this caused more efficient separation of electron-hole pairs. As a result, more radicals and holes were generated in the composite, leading to better photocatalytic performance. This work highlights the powerful combination of MOFs and semiconductor, which is a promising approach to fabricate heterojunction photocatalyst for wastewater purification.
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http://dx.doi.org/10.1016/j.jcis.2020.04.075DOI Listing
August 2020

Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors.

Eur J Med Chem 2017 Jul 12;134:230-241. Epub 2017 Apr 12.

College of Science, Xihua University, Sichuan 610039, China. Electronic address:

Human sirtuin 2 (SIRT2) plays pivotal roles in multiple biological processes such as cell cycle regulation, autophagy, immune and inflammatory responses. Dysregulation of SIRT2 was considered as a main aspect contributing to several human diseases, including cancer. Development of new potent and selective SIRT2 inhibitors is currently desirable, which may provide a new strategy for treatment of related diseases. Herein, a structure-based optimization approach led to new 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as SIRT2 inhibitors. SAR analyses with new synthesized derivatives revealed a number of new potent SIRT2 inhibitors, among which 28e is the most potent inhibitor with an IC value of 42 nM. The selectivity analyses found that 28e has a very good selectivity to SIRT2 over SIRT1 and SIRT3. In cellular assays, 28e showed a potent ability to inhibit human breast cancer cell line MCF-7 and increase the acetylation of α-tubulin in a dose-dependent manner. This study will aid further efforts to develop highly potent and selective SIRT2 inhibitors for the treatment of cancer and other related diseases.
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http://dx.doi.org/10.1016/j.ejmech.2017.04.010DOI Listing
July 2017

Sirtuin 5: a review of structure, known inhibitors and clues for developing new inhibitors.

Sci China Life Sci 2017 Mar 17;60(3):249-256. Epub 2016 Nov 17.

College of Food and Bioengineering, Xihua University, Sichuan, 610039, China.

Sirtuins (SIRTs) are nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylases, which regulate important biological processes ranging from apoptosis, age-associated pathophysiologies, adipocyte and muscle differentiation, and energy expenditure to gluconeogenesis. Very recently, sirtuin 5 (SIRT5) has received considerable attention due to that it was found to have weak deacetylase activity but strong desuccinylase, demalonylase and deglutarylase activities, and it was also found to be associated with several human diseases such as cancer, Alzheimer's disease, and Parkinson's disease. In this review, we for the first time summarized the structure characteristics, known peptide and smallmolecule inhibitors of SIRT5, extracted some clues from current available information and introduced some feasible, practical in silico methods, which might be useful in further efforts to develop new SIRT5 inhibitors.
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http://dx.doi.org/10.1007/s11427-016-0060-7DOI Listing
March 2017

Discovery and preliminary structure-activity relationship of 1H-indazoles with promising indoleamine-2,3-dioxygenase 1 (IDO1) inhibition properties.

Bioorg Med Chem 2016 12 6;24(23):6194-6205. Epub 2016 Oct 6.

Department of Chemistry, Xihua University, Chengdu 610039, PR China. Electronic address:

Indoleamine 2,3-dioxygenase 1 (IDO1)-mediated kynurenine pathway of tryptophan degradation is identified as an important immune effector pathway in the tumor cells to escape a potentially effective immune response. IDO1 is an attractive target for anticancer therapy and the discovery of IDO1 inhibitors has been intensely ongoing in both academic research laboratories and pharmaceutical organizations. Our study discovered that 1H-indazole was a novel key pharmacophore with potent IDO1 inhibitory activity. A series of new 1H-indazole derivatives were synthesized and determined the enzyme inhibitory activities, and the compound 2g exhibited the highest activity with an IC value of 5.3μM. The structure-activity relationships (SARs) analysis of the 1H-indazole derivatives as novel IDO1 inhibitors indicated that the 1H-indazole scaffold is necessary for IDO1 inhibition, and the substituent groups at the both 4-position and 6-position largely affect inhibitory activity. The docking model exhibited that the effective interactions of 1H-indazoles with ferrous ion of heme and key residues of hydrophobic Pocket A and B ensured the IDO1 inhibitory activities. The study suggested that the 1H-indazole was a novel interesting scaffold for IDO inhibition for further development.
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http://dx.doi.org/10.1016/j.bmc.2016.10.003DOI Listing
December 2016

Recent advances in the development of protein tyrosine phosphatase 1B inhibitors for Type 2 diabetes.

Future Med Chem 2016 07 30;8(11):1239-58. Epub 2016 Jun 30.

School of Food & Biotechnology, Xihua University, Chengdu 610039, PR China.

Diabetes mellitus is the most serious and prevalent metabolic disorders worldwide, complications of which can decrease significantly the quality of life and contribute to premature death. Resistance to insulin is a predominant pathophysiological factor of Type 2 diabetes (T2D). Protein tyrosine phosphatase 1B (PTP1B) is an important negative factor of insulin signal and a potent therapeutic target in T2D patients. This review highlights recent advances (2012-2015) in research related to the role of PTP1B in signal transduction processes implicated in pathophysiology of T2D, and novel PTP1B inhibitors with an emphasis on their chemical structures and modes of action.
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http://dx.doi.org/10.4155/fmc-2016-0064DOI Listing
July 2016
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