Yann Herault

Yann Herault

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Yann Herault

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High-throughput discovery of genetic determinants of circadian misalignment.

Authors:
Tao Zhang Pancheng Xie Yingying Dong Zhiwei Liu Fei Zhou Dejing Pan Zhengyun Huang Qiaocheng Zhai Yue Gu Qingyu Wu Nobuhiko Tanaka Yuichi Obata Allan Bradley Christopher J Lelliott Lauryl M J Nutter Colin McKerlie Ann M Flenniken Marie-France Champy Tania Sorg Yann Herault Martin Hrabe De Angelis Valerie Gailus Durner Ann-Marie Mallon Steve D M Brown Terry Meehan Helen E Parkinson Damian Smedley K C Kent Lloyd Jun Yan Xiang Gao Je Kyung Seong Chi-Kuang Leo Wang Radislav Sedlacek Yi Liu Jan Rozman Ling Yang Ying Xu

PLoS Genet 2020 Jan 13;16(1):e1008577. Epub 2020 Jan 13.

Cambridge-Suda Genomic Resource Center, Jiangsu Key Laboratory of Neuropsychiatric Diseases, Medical college of Soochow University, Suzhou, Jiangsu, China.

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http://dx.doi.org/10.1371/journal.pgen.1008577DOI Listing
January 2020

A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment.

Authors:
Anne-Cécile Guyot Charlotte Leuxe Clémence Disdier Nassima Oumata Narciso Costa Gwenaëlle Le Roux Paloma Fernandez-Varela Arnaud Duchon Jean Baptiste Charbonnier Yann Herault Serena Pavoni Hervé Galons Emile Andriambeloson Stéphanie Wagner Laurent Meijer Amie K Lund Aloïse Mabondzo

Sci Rep 2020 Jan 24;10(1):1143. Epub 2020 Jan 24.

Service de Pharmacologie et d'Immunoanalyse, CEA, Université Paris-Saclay, F-91191, Gif-sur Yvette, France.

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http://dx.doi.org/10.1038/s41598-020-57560-3DOI Listing
January 2020

Optimizing PCR for Mouse Genotyping: Recommendations for Reliable, Rapid, Cost Effective, Robust and Adaptable to High-Throughput Genotyping Protocol for Any Type of Mutation.

Authors:
Sylvie Jacquot Nathalie Chartoire Françoise Piguet Yann Hérault Guillaume Pavlovic

Curr Protoc Mouse Biol 2019 Dec;9(4):e65

Institut Clinique de la Souris, PHENOMIN-ICS, Illkirch, France.

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http://dx.doi.org/10.1002/cpmo.65DOI Listing
December 2019

The Human-Specific BOLA2 Duplication Modifies Iron Homeostasis and Anemia Predisposition in Chromosome 16p11.2 Autism Individuals.

Authors:
Giuliana Giannuzzi Paul J Schmidt Eleonora Porcu Gilles Willemin Katherine M Munson Xander Nuttle Rachel Earl Jacqueline Chrast Kendra Hoekzema Davide Risso Katrin Männik Pasquelena De Nittis Ethan D Baratz Yann Herault Xiang Gao Caroline C Philpott Raphael A Bernier Zoltan Kutalik Mark D Fleming Evan E Eichler Alexandre Reymond

Am J Hum Genet 2019 Nov 24;105(5):947-958. Epub 2019 Oct 24.

Center for Integrative Genomics, University of Lausanne, Lausanne, 1015, Switzerland.

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http://dx.doi.org/10.1016/j.ajhg.2019.09.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849090PMC
November 2019

BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr phosphorylation.

Authors:
Maxime Sartori Tiago Mendes Shruti Desai Alessia Lasorsa Adrien Herledan Nicolas Malmanche Petra Mäkinen Mikael Marttinen Idir Malki Julien Chapuis Amandine Flaig Anaïs-Camille Vreulx Marion Ciancia Philippe Amouyel Florence Leroux Benoit Déprez François-Xavier Cantrelle Damien Maréchal Laurent Pradier Mikko Hiltunen Isabelle Landrieu Devrim Kilinc Yann Herault Jocelyn Laporte Jean-Charles Lambert

Acta Neuropathol 2019 Oct 7;138(4):631-652. Epub 2019 May 7.

INSERM U1167, RID-AGE: Risk Factors and Molecular Determinants of Aging-Related Diseases, Institut Pasteur de Lille, 1 rue du Pr. Calmette, 59019, Lille, France.

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http://link.springer.com/10.1007/s00401-019-02017-9
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http://dx.doi.org/10.1007/s00401-019-02017-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778065PMC
October 2019

Soft Windowing Application to Improve Analysis of High-throughput Phenotyping Data.

Authors:
Hamed Haselimashhadi Jeremy C Mason Violeta Munoz-Fuentes Federico López-Gómez Kolawole Babalola Elif F Acar Vivek Kumar Jacqui White Ann M Flenniken Ruairidh King Ewan Straiton John Richard Seavitt Angelina Gaspero Arturo Garza Audrey E Christianson Chih-Wei Hsu Corey L Reynolds Denise G Lanza Isabel Lorenzo Jennie R Green Juan J Gallegos Ritu Bohat Rodney C Samaco Surabi Veeraragavan Jong Kyoung Kim Gregor Miller Helmult Fuchs Lillian Garrett Lore Becker Yeon Kyung Kang David Clary Soo Young Cho Masaru Tamura Nobuhiko Tanaka Kyung Dong Soo Alexandr Bezginov Ghina Bou About Marie-France Champy Laurent Vasseur Sophie Leblanc Hamid Meziane Mohammed Selloum Patrick T Reilly Nadine Spielmann Holger Maier Valerie Gailus-Durner Tania Sorg Masuya Hiroshi Obata Yuichi Jason D Heaney Mary E Dickinson Wurst Wolfgang Glauco P Tocchini-Valentini Kevin C Kent Lloyd Colin McKerlie Je Kyung Seong Herault Yann Martin Hrabé de Angelis Steve D M Brown Damian Smedley Paul Flicek Ann-Marie Mallon Helen Parkinson Terrence F Meehan

Bioinformatics 2019 Oct 8. Epub 2019 Oct 8.

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1093/bioinformatics/btz744DOI Listing
October 2019

Long-lasting correction of in vivo LTP and cognitive deficits of mice modelling Down syndrome with an α5-selective GABA inverse agonist.

Authors:
Arnaud Duchon Agnès Gruart Christelle Albac Benoît Delatour Javier Zorrilla de San Martin José María Delgado-García Yann Hérault Marie-Claude Potier

Br J Pharmacol 2019 Oct 25. Epub 2019 Oct 25.

Institut du Cerveau et de la Moelle épinière, Hôpital de la Pitié-Salpêtrière, Paris, France.

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http://dx.doi.org/10.1111/bph.14903DOI Listing
October 2019

Oligogenic Effects of 16p11.2 Copy-Number Variation on Craniofacial Development.

Authors:
Yuqi Qiu Thomas Arbogast Sandra Martin Lorenzo Hongying Li Shih C Tang Ellen Richardson Oanh Hong Shawn Cho Omar Shanta Timothy Pang Christina Corsello Curtis K Deutsch Claire Chevalier Erica E Davis Lilia M Iakoucheva Yann Herault Nicholas Katsanis Karen Messer Jonathan Sebat

Cell Rep 2019 Sep;28(13):3320-3328.e4

Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA; Beyster Center for Genomics of Psychiatric Diseases, University of California, San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.08.071DOI Listing
September 2019

HENA, heterogeneous network-based data set for Alzheimer's disease.

Authors:
Elena Sügis Jerome Dauvillier Anna Leontjeva Priit Adler Valerie Hindie Thomas Moncion Vincent Collura Rachel Daudin Yann Loe-Mie Yann Herault Jean-Charles Lambert Henning Hermjakob Tal Pupko Jean-Christophe Rain Ioannis Xenarios Jaak Vilo Michel Simonneau Hedi Peterson

Sci Data 2019 08 14;6(1):151. Epub 2019 Aug 14.

Quretec Ltd., Ülikooli 6a, 51003, Tartu, Estonia.

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http://dx.doi.org/10.1038/s41597-019-0152-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694132PMC
August 2019

Genetic quality assurance and genetic monitoring of laboratory mice and rats: FELASA Working Group Report.

Authors:
Fernando Benavides Thomas Rülicke Jan-Bas Prins James Bussell Ferdinando Scavizzi Paolo Cinelli Yann Herault Dirk Wedekind

Lab Anim 2019 Aug 20:23677219867719. Epub 2019 Aug 20.

10 Institute of Laboratory Animal Science, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1177/0023677219867719DOI Listing
August 2019

Ultrasound-Guided Approaches to Improve Orthotopic Mouse Xenograft Models for Hepatocellular Carcinoma.

Authors:
Ghina Bou About Emilie Thiebault Marie Wattenhofer-Donzé Hugues Jacobs Alain Guimond Tania Sorg Eric Robinet Thomas F Baumert Laurent Monassier Yann Herault

Curr Protoc Mouse Biol 2019 Jun 30;9(2):e62. Epub 2019 May 30.

Institut Clinique de la Souris, PHENOMIN-ICS, Illkirch, France.

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http://dx.doi.org/10.1002/cpmo.62DOI Listing
June 2019

Cbs overdosage is necessary and sufficient to induce cognitive phenotypes in mouse models of Down syndrome and interacts genetically with Dyrk1a.

Authors:
Damien Marechal Véronique Brault Alice Leon Dehren Martin Patricia Lopes Pereira Nadege Loaëc Marie-Christine Birling Gaelle Friocourt Marc Blondel Yann Herault

Hum Mol Genet 2019 05;28(9):1561-1577

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.

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http://dx.doi.org/10.1093/hmg/ddy447DOI Listing
May 2019

TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.

Authors:
Ekaterina L Ivanova Johan G Gilet Vadym Sulimenko Arnaud Duchon Gabrielle Rudolf Karen Runge Stephan C Collins Laure Asselin Loic Broix Nathalie Drouot Peggy Tilly Patrick Nusbaum Alexandre Vincent William Magnant Valerie Skory Marie-Christine Birling Guillaume Pavlovic Juliette D Godin Binnaz Yalcin Yann Hérault Pavel Dráber Jamel Chelly Maria-Victoria Hinckelmann

Nat Commun 2019 05 13;10(1):2129. Epub 2019 May 13.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67400, Illkirch, France.

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http://dx.doi.org/10.1038/s41467-019-10081-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513894PMC
May 2019

Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models.

Authors:
Benoit Souchet Arnaud Duchon Yuchen Gu Julien Dairou Claire Chevalier Fabrice Daubigney Valérie Nalesso Nicole Créau Yuejin Yu Nathalie Janel Yann Herault Jean Maurice Delabar

Sci Rep 2019 Mar 8;9(1):3914. Epub 2019 Mar 8.

Université Paris-Diderot, Sorbonne Paris Cité, Adaptive Functional Biology, National Centre for Scientific Research (CNRS), UMR 8251, Paris, France.

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http://dx.doi.org/10.1038/s41598-019-40328-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408590PMC
March 2019

Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts.

Authors:
Bret A Moore Brian C Leonard Lionel Sebbag Sydney G Edwards Ann Cooper Denise M Imai Ewan Straiton Luis Santos Christopher Reilly Stephen M Griffey Lynette Bower David Clary Jeremy Mason Michel J Roux Hamid Meziane Yann Herault Colin McKerlie Ann M Flenniken Lauryl M J Nutter Zorana Berberovic Celeste Owen Susan Newbigging Hibret Adissu Mohammed Eskandarian Chih-Wei Hsu Sowmya Kalaga Uchechukwu Udensi Chinwe Asomugha Ritu Bohat Juan J Gallegos John R Seavitt Jason D Heaney Arthur L Beaudet Mary E Dickinson Monica J Justice Vivek Philip Vivek Kumar Karen L Svenson Robert E Braun Sara Wells Heather Cater Michelle Stewart Sharon Clementson-Mobbs Russell Joynson Xiang Gao Tomohiro Suzuki Shigeharu Wakana Damian Smedley J K Seong Glauco Tocchini-Valentini Mark Moore Colin Fletcher Natasha Karp Ramiro Ramirez-Solis Jacqueline K White Martin Hrabe de Angelis Wolfgang Wurst Sara M Thomasy Paul Flicek Helen Parkinson Steve D M Brown Terrence F Meehan Patsy M Nishina Stephen A Murray Mark P Krebs Ann-Marie Mallon K C Kent Lloyd Christopher J Murphy Ala Moshiri

Commun Biol 2019 7;2:97. Epub 2019 Mar 7.

Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis, Sacramento, CA, 95817, USA.

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http://dx.doi.org/10.1038/s42003-019-0349-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405960PMC
March 2019

Amphiphysin 2 modulation rescues myotubular myopathy and prevents focal adhesion defects in mice.

Authors:
Valentina M Lionello Anne-Sophie Nicot Maxime Sartori Christine Kretz Pascal Kessler Suzie Buono Sarah Djerroud Nadia Messaddeq Pascale Koebel Ivana Prokic Yann Hérault Norma B Romero Jocelyn Laporte Belinda S Cowling

Sci Transl Med 2019 03;11(484)

IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), 67404 Illkirch, France.

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http://dx.doi.org/10.1126/scitranslmed.aav1866DOI Listing
March 2019

Identification of genes required for eye development by high-throughput screening of mouse knockouts.

Authors:
Bret A Moore Brian C Leonard Lionel Sebbag Sydney G Edwards Ann Cooper Denise M Imai Ewan Straiton Luis Santos Christopher Reilly Stephen M Griffey Lynette Bower David Clary Jeremy Mason Michel J Roux Hamid Meziane Yann Herault Colin McKerlie Ann M Flenniken Lauryl M J Nutter Zorana Berberovic Celeste Owen Susan Newbigging Hibret Adissu Mohammed Eskandarian Chih-Wei Hsu Sowmya Kalaga Uchechukwu Udensi Chinwe Asomugha Ritu Bohat Juan J Gallegos John R Seavitt Jason D Heaney Arthur L Beaudet Mary E Dickinson Monica J Justice Vivek Philip Vivek Kumar Karen L Svenson Robert E Braun Sara Wells Heather Cater Michelle Stewart Sharon Clementson-Mobbs Russell Joynson Xiang Gao Tomohiro Suzuki Shigeharu Wakana Damian Smedley J K Seong Glauco Tocchini-Valentini Mark Moore Colin Fletcher Natasha Karp Ramiro Ramirez-Solis Jacqueline K White Martin Hrabe de Angelis Wolfgang Wurst Sara M Thomasy Paul Flicek Helen Parkinson Steve D M Brown Terrence F Meehan Patsy M Nishina Stephen A Murray Mark P Krebs Ann-Marie Mallon K C Kent Lloyd Christopher J Murphy Ala Moshiri

Commun Biol 2018 21;1:236. Epub 2018 Dec 21.

Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis, Sacramento, CA, 95817, USA.

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http://dx.doi.org/10.1038/s42003-018-0226-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303268PMC
December 2018

Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A.

Authors:
Thu Lan Nguyen Arnaud Duchon Antigoni Manousopoulou Nadège Loaëc Benoît Villiers Guillaume Pani Meltem Karatas Anna E Mechling Laura-Adela Harsan Emmanuelle Limanton Jean-Pierre Bazureau François Carreaux Spiros D Garbis Laurent Meijer Yann Herault

Dis Model Mech 2018 09 27;11(9). Epub 2018 Sep 27.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Translational Medicine and Neurogenetics, 67400 Illkirch, France

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http://dmm.biologists.org/lookup/doi/10.1242/dmm.035634
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http://dx.doi.org/10.1242/dmm.035634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176987PMC
September 2018

Hepatocyte SHP deficiency protects mice from acetaminophen-evoked liver injury in a JNK-signaling regulation and GADD45β-dependent manner.

Authors:
Yong-Hoon Kim Jung-Ran Noh Jung Hwan Hwang Kyoung-Shim Kim Dong-Hee Choi Jae-Hoon Kim Sung Je Moon Ji Hyun Choi Yann Hérault Tae Geol Lee Hueng-Sik Choi Chul-Ho Lee

Arch Toxicol 2018 08 25;92(8):2563-2572. Epub 2018 Jun 25.

Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, South Korea.

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http://dx.doi.org/10.1007/s00204-018-2247-3DOI Listing
August 2018

Synaptic dysfunction in amygdala in intellectual disorder models.

Authors:
Marianne Aincy Hamid Meziane Yann Herault Yann Humeau

Prog Neuropsychopharmacol Biol Psychiatry 2018 06 1;84(Pt B):392-397. Epub 2017 Aug 1.

Team "synapse in cognition", UMR 5297, University of Bordeaux, Bordeaux, France; Team "synapse in cognition", UMR 5297, Centre National de la recherche scientifique, Bordeaux, France. Electronic address:

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http://dx.doi.org/10.1016/j.pnpbp.2017.07.028DOI Listing
June 2018

Increased H3K9 methylation and impaired expression of Protocadherins are associated with the cognitive dysfunctions of the Kleefstra syndrome.

Authors:
Giovanni Iacono Aline Dubos Hamid Méziane Marco Benevento Ehsan Habibi Amit Mandoli Fabrice Riet Mohammed Selloum Robert Feil Huiqing Zhou Tjitske Kleefstra Nael Nadif Kasri Hans van Bokhoven Yann Herault Hendrik G Stunnenberg

Nucleic Acids Res 2018 06;46(10):4950-4965

Radboud University, Department of Molecular Biology, Faculty of Science, 6500 HB Nijmegen, the Netherlands.

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https://academic.oup.com/nar/article/46/10/4950/4937548
Publisher Site
http://dx.doi.org/10.1093/nar/gky196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007260PMC
June 2018

A new mouse model of ARX dup24 recapitulates the patients' behavioral and fine motor alterations.

Authors:
Aline Dubos Hamid Meziane Giovanni Iacono Aurore Curie Fabrice Riet Christelle Martin Nadège Loaëc Marie-Christine Birling Mohammed Selloum Elisabeth Normand Guillaume Pavlovic Tania Sorg Henk G Stunnenberg Jamel Chelly Yann Humeau Gaëlle Friocourt Yann Hérault

Hum Mol Genet 2018 06;27(12):2138-2153

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg, 67404 Illkirch, France.

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http://dx.doi.org/10.1093/hmg/ddy122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985730PMC
June 2018

Translating molecular advances in Down syndrome and Fragile X syndrome into therapies.

Authors:
Victor Faundez Ilario De Toma Barbara Bardoni Renata Bartesaghi Dean Nizetic Rafael de la Torre Roi Cohen Kadosh Yann Herault Mara Dierssen Marie-Claude Potier

Eur Neuropsychopharmacol 2018 06 7;28(6):675-690. Epub 2018 Jun 7.

Institut du Cerveau et de la Moelle épinière, CNRS UMR7225, INSERM U1127, UPMC, Hôpital de la Pitié-Salpêtrière, 47 Bd de l'Hôpital, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2018.03.006DOI Listing
June 2018

A Population Study of Common Ocular Abnormalities in C57BL/6N rd8 Mice.

Authors:
Bret A Moore Michel J Roux Lionel Sebbag Ann Cooper Sydney G Edwards Brian C Leonard Denise M Imai Stephen Griffey Lynette Bower Dave Clary K C Kent Lloyd Yann Hérault Sara M Thomasy Christopher J Murphy Ala Moshiri

Invest Ophthalmol Vis Sci 2018 05;59(6):2252-2261

Department of Ophthalmology & Vision Science, School of Medicine, University of California-Davis, Sacramento, California, United States.

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http://dx.doi.org/10.1167/iovs.17-23513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935295PMC
May 2018

Nox4 genetic inhibition in experimental hypertension and metabolic syndrome.

Authors:
Ghina Bouabout Estelle Ayme-Dietrich Hugues Jacob Marie-France Champy Marie-Christine Birling Guillaume Pavlovic Lola Madeira Lahcen El Fertak Benoit Petit-Demoulière Tania Sorg Yann Herault John Mudgett Laurent Monassier

Arch Cardiovasc Dis 2018 Jan 4;111(1):41-52. Epub 2017 Nov 4.

Institut clinique de la Souris, institut de génétique et de biologie moléculaire et cellulaire, université de Strasbourg, Illkirch, France; Laboratoire de neurobiologie et pharmacologie cardiovasculaire, faculté de médecine, fédération de médecine translationnelle, université, CHU de Strasbourg, 11, rue Humann, 67085 Strasbourg cedex, France. Electronic address:

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http://dx.doi.org/10.1016/j.acvd.2017.03.011DOI Listing
January 2018

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.

Authors:
Jan Rozman Birgit Rathkolb Manuela A Oestereicher Christine Schütt Aakash Chavan Ravindranath Stefanie Leuchtenberger Sapna Sharma Martin Kistler Monja Willershäuser Robert Brommage Terrence F Meehan Jeremy Mason Hamed Haselimashhadi Tertius Hough Ann-Marie Mallon Sara Wells Luis Santos Christopher J Lelliott Jacqueline K White Tania Sorg Marie-France Champy Lynette R Bower Corey L Reynolds Ann M Flenniken Stephen A Murray Lauryl M J Nutter Karen L Svenson David West Glauco P Tocchini-Valentini Arthur L Beaudet Fatima Bosch Robert B Braun Michael S Dobbie Xiang Gao Yann Herault Ala Moshiri Bret A Moore K C Kent Lloyd Colin McKerlie Hiroshi Masuya Nobuhiko Tanaka Paul Flicek Helen E Parkinson Radislav Sedlacek Je Kyung Seong Chi-Kuang Leo Wang Mark Moore Steve D Brown Matthias H Tschöp Wolfgang Wurst Martin Klingenspor Eckhard Wolf Johannes Beckers Fausto Machicao Andreas Peter Harald Staiger Hans-Ulrich Häring Harald Grallert Monica Campillos Holger Maier Helmut Fuchs Valerie Gailus-Durner Thomas Werner Martin Hrabe de Angelis

Nat Commun 2018 01 18;9(1):288. Epub 2018 Jan 18.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1038/s41467-017-01995-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773596PMC
January 2018

Integrated transcriptional analysis unveils the dynamics of cellular differentiation in the developing mouse hippocampus.

Authors:
Giovanni Iacono Marco Benevento Aline Dubos Yann Herault Hans van Bokhoven Nael Nadif Kasri Hendrik G Stunnenberg

Sci Rep 2017 12 22;7(1):18073. Epub 2017 Dec 22.

Radboud University, Department of Molecular Biology, Faculty of Science, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-18287-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741714PMC
December 2017

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.

Authors:
Thu Lan Nguyen Corinne Fruit Yann Hérault Laurent Meijer Thierry Besson

Expert Opin Ther Pat 2017 Nov 2;27(11):1183-1199. Epub 2017 Aug 2.

f Normandie Univ , UNIROUEN, INSA Rouen, CNRS, COBRA UMR 6014 , Rouen , France.

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http://dx.doi.org/10.1080/13543776.2017.1360285DOI Listing
November 2017

Corrigendum: High-throughput discovery of novel developmental phenotypes.

Authors:
Mary E Dickinson Ann M Flenniken Xiao Ji Lydia Teboul Michael D Wong Jacqueline K White Terrence F Meehan Wolfgang J Weninger Henrik Westerberg Hibret Adissu Candice N Baker Lynette Bower James M Brown L Brianna Caddle Francesco Chiani Dave Clary James Cleak Mark J Daly James M Denegre Brendan Doe Mary E Dolan Sarah M Edie Helmut Fuchs Valerie Gailus-Durner Antonella Galli Alessia Gambadoro Juan Gallegos Shiying Guo Neil R Horner Chih-Wei Hsu Sara J Johnson Sowmya Kalaga Lance C Keith Louise Lanoue Thomas N Lawson Monkol Lek Manuel Mark Susan Marschall Jeremy Mason Melissa L McElwee Susan Newbigging Lauryl M J Nutter Kevin A Peterson Ramiro Ramirez-Solis Douglas J Rowland Edward Ryder Kaitlin E Samocha John R Seavitt Mohammed Selloum Zsombor Szoke-Kovacs Masaru Tamura Amanda G Trainor Ilinca Tudose Shigeharu Wakana Jonathan Warren Olivia Wendling David B West Leeyean Wong Atsushi Yoshiki Wolfgang Wurst Daniel G MacArthur Glauco P Tocchini-Valentini Xiang Gao Paul Flicek Allan Bradley William C Skarnes Monica J Justice Helen E Parkinson Mark Moore Sara Wells Robert E Braun Karen L Svenson Martin Hrabe de Angelis Yann Herault Tim Mohun Ann-Marie Mallon R Mark Henkelman Steve D M Brown David J Adams K C Kent Lloyd Colin McKerlie Arthur L Beaudet Maja Bućan Stephen A Murray

Nature 2017 11 8;551(7680):398. Epub 2017 Nov 8.

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http://dx.doi.org/10.1038/nature24643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849394PMC
November 2017

Rodent models in Down syndrome research: impact and future opportunities.

Authors:
Yann Herault Jean M Delabar Elizabeth M C Fisher Victor L J Tybulewicz Eugene Yu Veronique Brault

Dis Model Mech 2017 10;10(10):1165-1186

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, 1 rue Laurent Fries, 67404 Illkirch, France.

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http://dx.doi.org/10.1242/dmm.029728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665454PMC
October 2017

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.

Authors:
Michael R Bowl Michelle M Simon Neil J Ingham Simon Greenaway Luis Santos Heather Cater Sarah Taylor Jeremy Mason Natalja Kurbatova Selina Pearson Lynette R Bower Dave A Clary Hamid Meziane Patrick Reilly Osamu Minowa Lois Kelsey Glauco P Tocchini-Valentini Xiang Gao Allan Bradley William C Skarnes Mark Moore Arthur L Beaudet Monica J Justice John Seavitt Mary E Dickinson Wolfgang Wurst Martin Hrabe de Angelis Yann Herault Shigeharu Wakana Lauryl M J Nutter Ann M Flenniken Colin McKerlie Stephen A Murray Karen L Svenson Robert E Braun David B West K C Kent Lloyd David J Adams Jacqui White Natasha Karp Paul Flicek Damian Smedley Terrence F Meehan Helen E Parkinson Lydia M Teboul Sara Wells Karen P Steel Ann-Marie Mallon Steve D M Brown

Nat Commun 2017 10 12;8(1):886. Epub 2017 Oct 12.

Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire, OX11 0RD, UK.

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http://dx.doi.org/10.1038/s41467-017-00595-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638796PMC
October 2017

WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.

Authors:
Meghna Kannan Efil Bayam Christel Wagner Bruno Rinaldi Perrine F Kretz Peggy Tilly Marna Roos Lara McGillewie Séverine Bär Shilpi Minocha Claire Chevalier Chrystelle Po Jamel Chelly Jean-Louis Mandel Renato Borgatti Amélie Piton Craig Kinnear Ben Loos David J Adams Yann Hérault Stephan C Collins Sylvie Friant Juliette D Godin Binnaz Yalcin

Proc Natl Acad Sci U S A 2017 10 12;114(44):E9308-E9317. Epub 2017 Oct 12.

Department of Translational Medicine and Neurogenetics, Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67404 Illkirch, France;

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http://dx.doi.org/10.1073/pnas.1713625114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676932PMC
October 2017

Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.

Authors:
Terrence F Meehan Nathalie Conte David B West Julius O Jacobsen Jeremy Mason Jonathan Warren Chao-Kung Chen Ilinca Tudose Mike Relac Peter Matthews Natasha Karp Luis Santos Tanja Fiegel Natalie Ring Henrik Westerberg Simon Greenaway Duncan Sneddon Hugh Morgan Gemma F Codner Michelle E Stewart James Brown Neil Horner Melissa Haendel Nicole Washington Christopher J Mungall Corey L Reynolds Juan Gallegos Valerie Gailus-Durner Tania Sorg Guillaume Pavlovic Lynette R Bower Mark Moore Iva Morse Xiang Gao Glauco P Tocchini-Valentini Yuichi Obata Soo Young Cho Je Kyung Seong John Seavitt Arthur L Beaudet Mary E Dickinson Yann Herault Wolfgang Wurst Martin Hrabe de Angelis K C Kent Lloyd Ann M Flenniken Lauryl M J Nutter Susan Newbigging Colin McKerlie Monica J Justice Stephen A Murray Karen L Svenson Robert E Braun Jacqueline K White Allan Bradley Paul Flicek Sara Wells William C Skarnes David J Adams Helen Parkinson Ann-Marie Mallon Steve D M Brown Damian Smedley

Nat Genet 2017 Aug 26;49(8):1231-1238. Epub 2017 Jun 26.

William Harvey Research Institute, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1038/ng.3901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546242PMC
August 2017

Modeling human disease in rodents by CRISPR/Cas9 genome editing.

Authors:
Marie-Christine Birling Yann Herault Guillaume Pavlovic

Mamm Genome 2017 08 4;28(7-8):291-301. Epub 2017 Jul 4.

CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France.

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http://dx.doi.org/10.1007/s00335-017-9703-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569124PMC
August 2017

Introduction to Mammalian Genome Special Issue: Genome Editing.

Authors:
Lydia Teboul Yann Hérault Cynthia Smith Bruce Whitelaw

Mamm Genome 2017 08;28(7-8):235-236

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK.

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http://dx.doi.org/10.1007/s00335-017-9708-5DOI Listing
August 2017

Atp6ap2 ablation in adult mice impairs viability through multiple organ deficiencies.

Authors:
Olivia Wendling Marie-France Champy Solène Jaubert Guillaume Pavlovic Aline Dubos Loic Lindner Hugues Jacobs Manuel Mark Roy Combe Isabelle Goncalves Da Cruz Hervé Luche John S Mudgett Thomas Rosahl Tania Sorg Marie Malissen Patrick T Reilly Yann Hérault

Sci Rep 2017 08 29;7(1):9618. Epub 2017 Aug 29.

CELPHEDIA-PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, F-67404, Illkirch-Graffenstaden, France.

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http://dx.doi.org/10.1038/s41598-017-08845-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575319PMC
August 2017

Mouse models of 17q21.31 microdeletion and microduplication syndromes highlight the importance of Kansl1 for cognition.

Authors:
Thomas Arbogast Giovanni Iacono Claire Chevalier Nurudeen O Afinowi Xander Houbaert Matthijs C van Eede Christine Laliberte Marie-Christine Birling Katrin Linda Hamid Meziane Mohammed Selloum Tania Sorg Nael Nadif Kasri David A Koolen Henk G Stunnenberg R Mark Henkelman Maksym Kopanitsa Yann Humeau Bert B A De Vries Yann Herault

PLoS Genet 2017 Jul 13;13(7):e1006886. Epub 2017 Jul 13.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg, Illkirch, France.

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http://dx.doi.org/10.1371/journal.pgen.1006886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531616PMC
July 2017

A Fast, Easy, and Customizable Eight-Color Flow Cytometric Method for Analysis of the Cellular Content of Bronchoalveolar Lavage Fluid in the Mouse.

Authors:
François Daubeuf Julien Becker Juan Antonio Aguilar-Pimentel Claudine Ebel Martin Hrabě de Angelis Yann Hérault Nelly Frossard

Curr Protoc Mouse Biol 2017 Jun 19;7(2):88-99. Epub 2017 Jun 19.

Laboratoire d'Innovation Thérapeutique, Faculté de Pharmacie, Université de Strasbourg, Illkirch, France.

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http://dx.doi.org/10.1002/cpmo.26DOI Listing
June 2017

Prevalence of sexual dimorphism in mammalian phenotypic traits.

Authors:
Natasha A Karp Jeremy Mason Arthur L Beaudet Yoav Benjamini Lynette Bower Robert E Braun Steve D M Brown Elissa J Chesler Mary E Dickinson Ann M Flenniken Helmut Fuchs Martin Hrabe de Angelis Xiang Gao Shiying Guo Simon Greenaway Ruth Heller Yann Herault Monica J Justice Natalja Kurbatova Christopher J Lelliott K C Kent Lloyd Ann-Marie Mallon Judith E Mank Hiroshi Masuya Colin McKerlie Terrence F Meehan Richard F Mott Stephen A Murray Helen Parkinson Ramiro Ramirez-Solis Luis Santos John R Seavitt Damian Smedley Tania Sorg Anneliese O Speak Karen P Steel Karen L Svenson Shigeharu Wakana David West Sara Wells Henrik Westerberg Shay Yaacoby Jacqueline K White

Nat Commun 2017 06 26;8:15475. Epub 2017 Jun 26.

The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA.

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http://dx.doi.org/10.1038/ncomms15475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490203PMC
June 2017

Fluorescent nanodiamond tracking reveals intraneuronal transport abnormalities induced by brain-disease-related genetic risk factors.

Authors:
Simon Haziza Nitin Mohan Yann Loe-Mie Aude-Marie Lepagnol-Bestel Sophie Massou Marie-Pierre Adam Xuan Loc Le Julia Viard Christine Plancon Rachel Daudin Pascale Koebel Emilie Dorard Christiane Rose Feng-Jen Hsieh Chih-Che Wu Brigitte Potier Yann Herault Carlo Sala Aiden Corvin Bernadette Allinquant Huan-Cheng Chang François Treussart Michel Simonneau

Nat Nanotechnol 2017 05 28;12(4):322-328. Epub 2016 Nov 28.

Laboratoire Aimé Cotton, CNRS, Université Paris-Sud, ENS Cachan, Université Paris-Saclay, 91405 Orsay, France.

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http://dx.doi.org/10.1038/nnano.2016.260DOI Listing
May 2017

Efficient and rapid generation of large genomic variants in rats and mice using CRISMERE.

Authors:
Marie-Christine Birling Laurence Schaeffer Philippe André Loic Lindner Damien Maréchal Abdel Ayadi Tania Sorg Guillaume Pavlovic Yann Hérault

Sci Rep 2017 03 7;7:43331. Epub 2017 Mar 7.

PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, F-67404 Illkirch-Graffenstaden, France.

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http://dx.doi.org/10.1038/srep43331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339700PMC
March 2017

Physiological Expression of AMPKγ2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice.

Authors:
Xiaodong Yang John Mudgett Ghina Bou-About Marie-France Champy Hugues Jacobs Laurent Monassier Guillaume Pavlovic Tania Sorg Yann Herault Benoit Petit-Demoulière Ku Lu Wen Feng Hongwu Wang Li-Jun Ma Roger Askew Mark D Erion David E Kelley Robert W Myers Cai Li Hong-Ping Guan

J Biol Chem 2016 Nov 12;291(45):23428-23439. Epub 2016 Sep 12.

From the Departments of Cardiometabolic Disease,

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http://www.jbc.org/content/early/2016/09/12/jbc.M116.738591.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095399PMC
November 2016

The DNA methyltransferase DNMT3C protects male germ cells from transposon activity.

Authors:
Joan Barau Aurélie Teissandier Natasha Zamudio Stéphanie Roy Valérie Nalesso Yann Hérault Florian Guillou Déborah Bourc'his

Science 2016 11;354(6314):909-912

Institut Curie, PSL Research University, INSERM, CNRS, 75005 Paris, France.

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http://dx.doi.org/10.1126/science.aah5143DOI Listing
November 2016

Erratum: A suppressor locus for MODY3-diabetes.

Authors:
Miguel A Garcia-Gonzalez Claire Carette Alessia Bagattin Magali Chiral Munevver Parla Makinistoglu Serge Garbay Géraldine Prévost Cécile Madaras Yann Hérault Michel Leibovici Marco Pontoglio

Sci Rep 2016 10 21;6:35697. Epub 2016 Oct 21.

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http://dx.doi.org/10.1038/srep35697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073365PMC
October 2016

E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis.

Authors:
Perrine Goguet-Rubio Berfin Seyran Laurie Gayte Florence Bernex Anne Sutter Hélène Delpech Laetitia Karine Linares Romain Riscal Cendrine Repond Geneviève Rodier Olivier Kirsh Jawida Touhami Jean Noel Charles Vincent Nelly Pirot Guillaume Pavlovic Yann Herault Marc Sitbon Luc Pellerin Claude Sardet Matthieu Lacroix Laurent Le Cam

Proc Natl Acad Sci U S A 2016 09 12;113(39):11004-9. Epub 2016 Sep 12.

Institut de Recherche en Cancérologie de Montpellier, Montpellier F-34298, France; INSERM U1194, Montpellier F-34298, France; University of Montpellier, Montpellier F-34090, France; Institut Régional du Cancer de Montpellier, Montpellier F-34298, France; Equipe labellisée Ligue Contre le Cancer, 75013 Paris, France;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047149PMC
http://dx.doi.org/10.1073/pnas.1602751113DOI Listing
September 2016

High-throughput discovery of novel developmental phenotypes.

Authors:
Mary E Dickinson Ann M Flenniken Xiao Ji Lydia Teboul Michael D Wong Jacqueline K White Terrence F Meehan Wolfgang J Weninger Henrik Westerberg Hibret Adissu Candice N Baker Lynette Bower James M Brown L Brianna Caddle Francesco Chiani Dave Clary James Cleak Mark J Daly James M Denegre Brendan Doe Mary E Dolan Sarah M Edie Helmut Fuchs Valerie Gailus-Durner Antonella Galli Alessia Gambadoro Juan Gallegos Shiying Guo Neil R Horner Chih-Wei Hsu Sara J Johnson Sowmya Kalaga Lance C Keith Louise Lanoue Thomas N Lawson Monkol Lek Manuel Mark Susan Marschall Jeremy Mason Melissa L McElwee Susan Newbigging Lauryl M J Nutter Kevin A Peterson Ramiro Ramirez-Solis Douglas J Rowland Edward Ryder Kaitlin E Samocha John R Seavitt Mohammed Selloum Zsombor Szoke-Kovacs Masaru Tamura Amanda G Trainor Ilinca Tudose Shigeharu Wakana Jonathan Warren Olivia Wendling David B West Leeyean Wong Atsushi Yoshiki Daniel G MacArthur Glauco P Tocchini-Valentini Xiang Gao Paul Flicek Allan Bradley William C Skarnes Monica J Justice Helen E Parkinson Mark Moore Sara Wells Robert E Braun Karen L Svenson Martin Hrabe de Angelis Yann Herault Tim Mohun Ann-Marie Mallon R Mark Henkelman Steve D M Brown David J Adams K C Kent Lloyd Colin McKerlie Arthur L Beaudet Maja Bućan Stephen A Murray

Nature 2016 09 14;537(7621):508-514. Epub 2016 Sep 14.

The Jackson Laboratory, Bar Harbor, Maine 04609, USA.

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http://dx.doi.org/10.1038/nature19356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295821PMC
September 2016

A suppressor locus for MODY3-diabetes.

Authors:
Miguel A Garcia-Gonzalez Claire Carette Alessia Bagattin Magali Chiral Munevver Parla Makinistoglu Serge Garbay Géraldine Prévost Cécile Madaras Yann Hérault Michel Leibovici Marco Pontoglio

Sci Rep 2016 Sep 26;6:33087. Epub 2016 Sep 26.

Laboratoire d' Expression Génique, Développement et Maladies (EGDM), Département Développement, Reproduction et Cancer, INSERM U1016, Institut Cochin, Paris, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036084PMC
http://dx.doi.org/10.1038/srep33087DOI Listing
September 2016

How Does Circadian Rhythm Impact Salt Sensitivity of Blood Pressure in Mice? A Study in Two Close C57Bl/6 Substrains.

Authors:
Roy Combe John Mudgett Lahcen El Fertak Marie-France Champy Estelle Ayme-Dietrich Benoit Petit-Demoulière Tania Sorg Yann Herault Jeffrey B Madwed Laurent Monassier

PLoS One 2016 18;11(4):e0153472. Epub 2016 Apr 18.

Institut Clinique de la Souris, Institut de Génétique et de Biologie Moléculaire, Université de Strasbourg, Illkirch, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153472PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835052PMC
August 2016

Aneuploidy screening of embryonic stem cell clones by metaphase karyotyping and droplet digital polymerase chain reaction.

Authors:
Gemma F Codner Loic Lindner Adam Caulder Marie Wattenhofer-Donzé Adam Radage Annelyse Mertz Benjamin Eisenmann Joffrey Mianné Edward P Evans Colin V Beechey Martin D Fray Marie-Christine Birling Yann Hérault Guillaume Pavlovic Lydia Teboul

BMC Cell Biol 2016 08 5;17(1):30. Epub 2016 Aug 5.

The Mary Lyon Centre, Medical Research Council Harwell Institute, Harwell Science and Innovation Campus, Didcot, OX11 0RD, Oxon, UK.

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http://dx.doi.org/10.1186/s12860-016-0108-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974727PMC
August 2016

DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome.

Authors:
Arnaud Duchon Yann Herault

Front Behav Neurosci 2016 3;10:104. Epub 2016 Jun 3.

Department of Translational Medicine and Neurogenetics, Institut de Génétique et de Biologie Moléculaire et CellulaireIllkirch, France; UMR7104, Centre National de la Recherche ScientifiqueIllkirch, France; U964, Institut National de la Santé et de la Recherche MédicaleIllkirch, France; Université de StrasbourgIllkirch, France; PHENOMIN, Institut Clinique de la Souris, Groupement d'Intérêt Économique-Centre Européen de Recherche en Biologie et en Médecine, CNRS, INSERMIllkirch-Graffenstaden, France.

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http://dx.doi.org/10.3389/fnbeh.2016.00104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891327PMC
July 2016

Fasudil treatment in adult reverses behavioural changes and brain ventricular enlargement in Oligophrenin-1 mouse model of intellectual disability.

Authors:
Hamid Meziane Malik Khelfaoui Noemi Morello Bassem Hiba Eleonora Calcagno Sophie Reibel-Foisset Mohammed Selloum Jamel Chelly Yann Humeau Fabrice Riet Ginevra Zanni Yann Herault Thierry Bienvenu Maurizio Giustetto Pierre Billuart

Hum Mol Genet 2016 06 4;25(11):2314-2323. Epub 2016 May 4.

Institut Cochin, INSERM U1016, CNRS UMR8104, Paris Descartes University, Paris, 75014, France

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http://dx.doi.org/10.1093/hmg/ddw102DOI Listing
June 2016

LXR-Mediated ABCA1 Expression and Function Are Modulated by High Glucose and PRMT2.

Authors:
Maryem A Hussein Elina Shrestha Mireille Ouimet Tessa J Barrett Sarah Leone Kathryn J Moore Yann Hérault Edward A Fisher Michael J Garabedian

PLoS One 2015 19;10(8):e0135218. Epub 2015 Aug 19.

Department of Microbiology, NYU School of Medicine, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135218PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545936PMC
May 2016

Corrigendum: Domains of genome-wide gene expression dysregulation in Down's syndrome.

Authors:
Audrey Letourneau Federico A Santoni Ximena Bonilla M Reza Sailani David Gonzalez Jop Kind Claire Chevalier Robert Thurman Richard S Sandstrom Youssef Hibaoui Marco Garieri Konstantin Popadin Emilie Falconnet Maryline Gagnebin Corinne Gehrig Anne Vannier Michel Guipponi Laurent Farinelli Daniel Robyr Eugenia Migliavacca Christelle Borel Samuel Deutsch Anis Feki John A Stamatoyannopoulos Yann Herault Bas van Steensel Roderic Guigo Stylianos E Antonarakis

Nature 2016 Mar 2;531(7594):400. Epub 2015 Dec 2.

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http://dx.doi.org/10.1038/nature16135DOI Listing
March 2016

Reciprocal Effects on Neurocognitive and Metabolic Phenotypes in Mouse Models of 16p11.2 Deletion and Duplication Syndromes.

Authors:
Thomas Arbogast Abdel-Mouttalib Ouagazzal Claire Chevalier Maksym Kopanitsa Nurudeen Afinowi Eugenia Migliavacca Belinda S Cowling Marie-Christine Birling Marie-France Champy Alexandre Reymond Yann Herault

PLoS Genet 2016 Feb 12;12(2):e1005709. Epub 2016 Feb 12.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.

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http://dx.doi.org/10.1371/journal.pgen.1005709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752317PMC
February 2016

Altered microtubule dynamics and vesicular transport in mouse and human MeCP2-deficient astrocytes.

Authors:
Chloé Delépine Hamid Meziane Juliette Nectoux Matthieu Opitz Amos B Smith Carlo Ballatore Yoann Saillour Annelise Bennaceur-Griscelli Qiang Chang Emily Cunningham Williams Maxime Dahan Aurélien Duboin Pierre Billuart Yann Herault Thierry Bienvenu

Hum Mol Genet 2016 Jan 24;25(1):146-57. Epub 2015 Nov 24.

Inserm, U1016, Institut Cochin, Paris, France, Cnrs, UMR8104, Paris, France, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, Laboratoire de Biologie et Génétique Moléculaires, HUPC, Hôpital Cochin, Paris, France,

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http://dx.doi.org/10.1093/hmg/ddv464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690499PMC
January 2016

Dyrk1A induces pancreatic β cell mass expansion and improves glucose tolerance.

Authors:
Latif Rachdi Dulanjalee Kariyawasam Virginie Aïello Yann Herault Nathalie Janel Jean-Maurice Delabar Michel Polak Raphaël Scharfmann

Cell Cycle 2014 28;13(14):2221-9. Epub 2014 May 28.

INSERM U1016; Institut Cochin; Faculté de Médecine Cochin; Université Paris Descartes; Paris, France.

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http://dx.doi.org/10.4161/cc.29250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111677PMC
December 2015

Impact of temporal variation on design and analysis of mouse knockout phenotyping studies.

Authors:
Natasha A Karp Anneliese O Speak Jacqueline K White David J Adams Martin Hrabé de Angelis Yann Hérault Richard F Mott

PLoS One 2014 24;9(10):e111239. Epub 2014 Oct 24.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111239PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208881PMC
December 2015

Dosage of the Abcg1-U2af1 region modifies locomotor and cognitive deficits observed in the Tc1 mouse model of Down syndrome.

Authors:
Damien Marechal Patricia Lopes Pereira Arnaud Duchon Yann Herault

PLoS One 2015 23;10(2):e0115302. Epub 2015 Feb 23.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, 1 rue Laurent Fries, 67404 Illkirch, France; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France; Université de Strasbourg, Illkirch, France; Institut Clinique de la Souris, ICS, 1 rue Laurent Fries, 67404 Illkirch, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115302PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338106PMC
December 2015

Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration.

Authors:
Aline Dubos Anna Castells-Nobau Hamid Meziane Merel A W Oortveld Xander Houbaert Giovanni Iacono Christelle Martin Christophe Mittelhaeuser Valérie Lalanne Jamie M Kramer Anuradha Bhukel Christine Quentin Jan Slabbert Patrik Verstreken Stefan J Sigrist Nadia Messaddeq Marie-Christine Birling Mohammed Selloum Henk G Stunnenberg Yann Humeau Annette Schenck Yann Herault

Hum Mol Genet 2015 Dec 16;24(23):6736-55. Epub 2015 Sep 16.

Institut Clinique de la Souris, PHENOMIN, GIE CERBM, 1 rue Laurent Fries, 67404 Illkirch, France, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France, Centre National de la Recherche Scientifique, UMR7104, Illkirch, France, Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France and Université de Strasbourg, Illkirch, France

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http://dx.doi.org/10.1093/hmg/ddv380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634377PMC
December 2015

Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models.

Authors:
Benoit Souchet Fayçal Guedj Zsuza Penke-Verdier Fabrice Daubigney Arnaud Duchon Yann Herault Jean-Charles Bizot Nathalie Janel Nicole Créau Benoit Delatour Jean M Delabar

Front Behav Neurosci 2015 20;9:267. Epub 2015 Oct 20.

Université Paris Diderot, Sorbonne Paris Cité, Adaptive Functional Biology, UMR Centre National de la Recherche Scientifique 8251 Paris, France ; Université Pierre-et-Marie-Curie Paris, 06 UMR S 1127, Centre National de la Recherche Scientifique UMR 7225, Institut National de la Santé et de la Recherche Médicale, U 1127, Sorbonne Universités, Institut du Cerveau et de la Moelle Epiniere Paris, France.

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http://dx.doi.org/10.3389/fnbeh.2015.00267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611057PMC
November 2015

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

Authors:
Martin Hrabě de Angelis George Nicholson Mohammed Selloum Jacqui White Hugh Morgan Ramiro Ramirez-Solis Tania Sorg Sara Wells Helmut Fuchs Martin Fray David J Adams Niels C Adams Thure Adler Antonio Aguilar-Pimentel Dalila Ali-Hadji Gregory Amann Philippe André Sarah Atkins Aurelie Auburtin Abdel Ayadi Julien Becker Lore Becker Elodie Bedu Raffi Bekeredjian Marie-Christine Birling Andrew Blake Joanna Bottomley Mike Bowl Véronique Brault Dirk H Busch James N Bussell Julia Calzada-Wack Heather Cater Marie-France Champy Philippe Charles Claire Chevalier Francesco Chiani Gemma F Codner Roy Combe Roger Cox Emilie Dalloneau André Dierich Armida Di Fenza Brendan Doe Arnaud Duchon Oliver Eickelberg Chris T Esapa Lahcen El Fertak Tanja Feigel Irina Emelyanova Jeanne Estabel Jack Favor Ann Flenniken Alessia Gambadoro Lilian Garrett Hilary Gates Anna-Karin Gerdin George Gkoutos Simon Greenaway Lisa Glasl Patrice Goetz Isabelle Goncalves Da Cruz Alexander Götz Jochen Graw Alain Guimond Wolfgang Hans Geoff Hicks Sabine M Hölter Heinz Höfler John M Hancock Robert Hoehndorf Tertius Hough Richard Houghton Anja Hurt Boris Ivandic Hughes Jacobs Sylvie Jacquot Nora Jones Natasha A Karp Hugo A Katus Sharon Kitchen Tanja Klein-Rodewald Martin Klingenspor Thomas Klopstock Valerie Lalanne Sophie Leblanc Christoph Lengger Elise le Marchand Tonia Ludwig Aline Lux Colin McKerlie Holger Maier Jean-Louis Mandel Susan Marschall Manuel Mark David G Melvin Hamid Meziane Kateryna Micklich Christophe Mittelhauser Laurent Monassier David Moulaert Stéphanie Muller Beatrix Naton Frauke Neff Patrick M Nolan Lauryl Mj Nutter Markus Ollert Guillaume Pavlovic Natalia S Pellegata Emilie Peter Benoit Petit-Demoulière Amanda Pickard Christine Podrini Paul Potter Laurent Pouilly Oliver Puk David Richardson Stephane Rousseau Leticia Quintanilla-Fend Mohamed M Quwailid Ildiko Racz Birgit Rathkolb Fabrice Riet Janet Rossant Michel Roux Jan Rozman Ed Ryder Jennifer Salisbury Luis Santos Karl-Heinz Schäble Evelyn Schiller Anja Schrewe Holger Schulz Ralf Steinkamp Michelle Simon Michelle Stewart Claudia Stöger Tobias Stöger Minxuan Sun David Sunter Lydia Teboul Isabelle Tilly Glauco P Tocchini-Valentini Monica Tost Irina Treise Laurent Vasseur Emilie Velot Daniela Vogt-Weisenhorn Christelle Wagner Alison Walling Bruno Weber Olivia Wendling Henrik Westerberg Monja Willershäuser Eckhard Wolf Anne Wolter Joe Wood Wolfgang Wurst Ali Önder Yildirim Ramona Zeh Andreas Zimmer Annemarie Zimprich Chris Holmes Karen P Steel Yann Herault Valérie Gailus-Durner Ann-Marie Mallon Steve Dm Brown

Nat Genet 2015 Sep 27;47(9):969-978. Epub 2015 Jul 27.

MRC Harwell, Medical Research Council, Harwell, UK.

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http://dx.doi.org/10.1038/ng.3360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564951PMC
September 2015

Deletion of the App-Runx1 region in mice models human partial monosomy 21.

Authors:
Thomas Arbogast Matthieu Raveau Claire Chevalier Valérie Nalesso Doulaye Dembele Hugues Jacobs Olivia Wendling Michel Roux Arnaud Duchon Yann Herault

Dis Model Mech 2015 Jun 16;8(6):623-34. Epub 2015 Apr 16.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Translational Medicine and Neurogenetics, 1 rue Laurent Fries, Illkirch 67404, France Centre National de la Recherche Scientifique, UMR7104, Illkirch 67404, France Institut National de la Santé et de la Recherche Médicale, U964, Illkirch 67404, France Université de Strasbourg, Illkirch 67404, France Institut Clinique de la Souris, PHENOMIN-ICS, CNRS, INSERM, Université de Strasbourg, 1 rue Laurent Fries, Illkirch 67404, France

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http://dx.doi.org/10.1242/dmm.017814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457029PMC
June 2015

Applying the ARRIVE Guidelines to an In Vivo Database.

Authors:
Natasha A Karp Terry F Meehan Hugh Morgan Jeremy C Mason Andrew Blake Natalja Kurbatova Damian Smedley Julius Jacobsen Richard F Mott Vivek Iyer Peter Matthews David G Melvin Sara Wells Ann M Flenniken Hiroshi Masuya Shigeharu Wakana Jacqueline K White K C Kent Lloyd Corey L Reynolds Richard Paylor David B West Karen L Svenson Elissa J Chesler Martin Hrabě de Angelis Glauco P Tocchini-Valentini Tania Sorg Yann Herault Helen Parkinson Ann-Marie Mallon Steve D M Brown

PLoS Biol 2015 May 20;13(5):e1002151. Epub 2015 May 20.

Mammalian Genetics Unit, Medical Research Council, Harwell, United Kingdom.

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http://dx.doi.org/10.1371/journal.pbio.1002151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439173PMC
May 2015

Opposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal Hspa13-App region.

Authors:
Véronique Brault Arnaud Duchon Caroline Romestaing Ignasi Sahun Stéphanie Pothion Mona Karout Christelle Borel Doulaye Dembele Jean-Charles Bizot Nadia Messaddeq Andrew J Sharp Damien Roussel Stylianos E Antonarakis Mara Dierssen Yann Hérault

PLoS Genet 2015 Mar 24;11(3):e1005062. Epub 2015 Mar 24.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France; Université de Strasbourg, Illkirch, France; Institut Clinique de la Souris, PHENOMIN, GIE CERBM, Illkirch, France.

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http://dx.doi.org/10.1371/journal.pgen.1005062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372517PMC
March 2015

Heterozygous deletion of the Williams-Beuren syndrome critical interval in mice recapitulates most features of the human disorder.

Authors:
Maria Segura-Puimedon Ignasi Sahún Emilie Velot Pierre Dubus Cristina Borralleras Ana J Rodrigues María C Valero Olga Valverde Nuno Sousa Yann Herault Mara Dierssen Luis A Pérez-Jurado Victoria Campuzano

Hum Mol Genet 2014 Dec 15;23(24):6481-94. Epub 2014 Jul 15.

Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Spain, Neurosciences Program, Institut Hospital del Mar D'Investigacions Mèdiques (IMIM), Barcelona 08003, Spain,

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http://dx.doi.org/10.1093/hmg/ddu368DOI Listing
December 2014

Targeted deletion of kidney glucose-6 phosphatase leads to nephropathy.

Authors:
Julie Clar Blandine Gri Julien Calderaro Marie-Christine Birling Yann Hérault G Peter A Smit Gilles Mithieux Fabienne Rajas

Kidney Int 2014 Oct 9;86(4):747-56. Epub 2014 Apr 9.

1] Institut National de la Santé et de la Recherche Médicale, U855, Lyon, France [2] Université de Lyon, Lyon, France [3] Université Lyon 1, Villeurbanne, France.

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http://dx.doi.org/10.1038/ki.2014.102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678048PMC
October 2014

Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage.

Authors:
Benoit Souchet Fayçal Guedj Ignasi Sahún Arnaud Duchon Fabrice Daubigney Anne Badel Yuchio Yanagawa Maria Jose Barallobre Mara Dierssen Eugene Yu Yann Herault Mariona Arbones Nathalie Janel Nicole Créau Jean Maurice Delabar

Neurobiol Dis 2014 Sep 4;69:65-75. Epub 2014 May 4.

Univ Paris Diderot, Sorbonne Paris Cité, Adaptive Functional Biology, UMR CNRS 8251, 75205 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.04.016DOI Listing
September 2014

Cognition and hippocampal plasticity in the mouse is altered by monosomy of a genomic region implicated in Down syndrome.

Authors:
Ignasi Sahún Damien Marechal Patricia Lopes Pereira Valérie Nalesso Agnes Gruart José Maria Delgado Garcia Stylianos E Antonarakis Mara Dierssen Yann Herault

Genetics 2014 Jul 21;197(3):899-912. Epub 2014 Apr 21.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, 67404 Illkirch, France Centre National de la Recherche Scientifique, UMR7104, Illkirch, France Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France Université de Strasbourg, 67400 Illkirch, France Institut Clinique de la Souris, PHENOMIN, Groupement d'Intérêt Economique Centre Européen de Recherche en Biologie Moléculaire, 67404 Illkirch, France

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http://dx.doi.org/10.1534/genetics.114.165241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096369PMC
July 2014

Domains of genome-wide gene expression dysregulation in Down's syndrome.

Authors:
Audrey Letourneau Federico A Santoni Ximena Bonilla M Reza Sailani David Gonzalez Jop Kind Claire Chevalier Robert Thurman Richard S Sandstrom Youssef Hibaoui Marco Garieri Konstantin Popadin Emilie Falconnet Maryline Gagnebin Corinne Gehrig Anne Vannier Michel Guipponi Laurent Farinelli Daniel Robyr Eugenia Migliavacca Christelle Borel Samuel Deutsch Anis Feki John A Stamatoyannopoulos Yann Herault Bas van Steensel Roderic Guigo Stylianos E Antonarakis

Nature 2014 Apr;508(7496):345-50

1] Department of Genetic Medicine and Development, University of Geneva Medical School, University Hospitals of Geneva, 1211 Geneva, Switzerland [2] iGE3 Institute of Genetics and Genomics of Geneva, 1211 Geneva, Switzerland.

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http://dx.doi.org/10.1038/nature13200DOI Listing
April 2014

Developmental molecular and functional cerebellar alterations induced by PCP4/PEP19 overexpression: implications for Down syndrome.

Authors:
François Mouton-Liger Ignasi Sahún Thibault Collin Patricia Lopes Pereira Debora Masini Sophie Thomas Evelyne Paly Sabrina Luilier Sandra Même Quentin Jouhault Soumia Bennaï Jean-Claude Beloeil Jean-Charles Bizot Yann Hérault Mara Dierssen Nicole Créau

Neurobiol Dis 2014 Mar 28;63:92-106. Epub 2013 Nov 28.

Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, EAC4413 CNRS, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2013.11.016DOI Listing
March 2014

Skin progenitor cells contribute to bleomycin-induced skin fibrosis.

Authors:
Shangxi Liu Yann Herault Guillaume Pavlovic Andrew Leask

Arthritis Rheumatol 2014 Mar;66(3):707-13

Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1002/art.38276DOI Listing
March 2014

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans.

Authors:
Rafael De la Torre Susana De Sola Meritxell Pons Arnaud Duchon María Martínez de Lagran Magí Farré Montserrat Fitó Bessy Benejam Klaus Langohr Joan Rodriguez Mitona Pujadas Jean Charles Bizot Aída Cuenca Nathalie Janel Silvina Catuara Maria Isabel Covas Henri Blehaut Yann Herault Jean Marie Delabar Mara Dierssen

Mol Nutr Food Res 2014 Feb 14;58(2):278-88. Epub 2013 Sep 14.

Human Pharmacology and Clinical Neurosciences Research Group-Neurosciences Program, IMIM-Hospital del Mar Research Institute, Barcelona, Spain; Cardiovascular Risk and Nutrition Research Group-Inflammatory and Cardiovascular Disorders Program, IMIM-Hospital del Mar Research Institute, and CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Barcelona, Spain; University Pompeu Fabra, CEXS-UPF, Barcelona, Spain.

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http://dx.doi.org/10.1002/mnfr.201300325DOI Listing
February 2014

Surveying the Down syndrome mouse model resource identifies critical regions responsible for chronic otitis media.

Authors:
Mahmood F Bhutta Michael T Cheeseman Yann Herault Yuejin E Yu Steve D M Brown

Mamm Genome 2013 Dec 26;24(11-12):439-45. Epub 2013 Sep 26.

Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Room 6607 Level 6, Headley Way, Oxford, OX3 9DU, UK,

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http://dx.doi.org/10.1007/s00335-013-9475-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843744PMC
December 2013

Distinct fibroblast lineages determine dermal architecture in skin development and repair.

Authors:
Ryan R Driskell Beate M Lichtenberger Esther Hoste Kai Kretzschmar Ben D Simons Marika Charalambous Sacri R Ferron Yann Herault Guillaume Pavlovic Anne C Ferguson-Smith Fiona M Watt

Nature 2013 Dec;504(7479):277-281

Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge CB2 1QR, UK.

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http://dx.doi.org/10.1038/nature12783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868929PMC
December 2013

DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels.

Authors:
Asma Tlili Christophe Noll Sandrine Middendorp Arnaud Duchon Marie Jouan Eva Benabou Yann Hérault Jean-Louis Paul Jean-Maurice Delabar Nathalie Janel

Mol Genet Metab 2013 Nov 20;110(3):371-7. Epub 2013 Jul 20.

Université Paris Diderot, Sorbonne Paris Cité, Unit of Functional and Adaptive Biology (BFA), EAC-CNRS 4413, Case 7104, 75205 Paris cedex 13, France.

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http://dx.doi.org/10.1016/j.ymgme.2013.07.014DOI Listing
November 2013

The homeodomain factor Gbx1 is required for locomotion and cell specification in the dorsal spinal cord.

Authors:
Hamid Meziane Valérie Fraulob Fabrice Riet Wojciech Krezel Mohammed Selloum Michaela Geffarth Dario Acampora Yann Hérault Antonio Simeone Michael Brand Pascal Dollé Muriel Rhinn

PeerJ 2013 29;1:e142. Epub 2013 Aug 29.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Université de Strasbourg, Illkirch Cedex, France.

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http://dx.doi.org/10.7717/peerj.142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757465PMC
September 2013

FELASA guidelines for the refinement of methods for genotyping genetically-modified rodents: a report of the Federation of European Laboratory Animal Science Associations Working Group.

Authors:
Dolores Bonaparte Paolo Cinelli Eleni Douni Yann Hérault Maas Maas Pirjo Pakarinen Matti Poutanen Mirentxu Santos Lafuente Ferdinando Scavizzi

Lab Anim 2013 Jul;47(3):134-45

SPCAL, Sociedade Portuguesa de Ciências em Animais de Laboratório.

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http://journals.sagepub.com/doi/10.1177/0023677212473918
Publisher Site
http://dx.doi.org/10.1177/0023677212473918DOI Listing
July 2013

A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains.

Authors:
Michelle M Simon Simon Greenaway Jacqueline K White Helmut Fuchs Valérie Gailus-Durner Sara Wells Tania Sorg Kim Wong Elodie Bedu Elizabeth J Cartwright Romain Dacquin Sophia Djebali Jeanne Estabel Jochen Graw Neil J Ingham Ian J Jackson Andreas Lengeling Silvia Mandillo Jacqueline Marvel Hamid Meziane Frédéric Preitner Oliver Puk Michel Roux David J Adams Sarah Atkins Abdel Ayadi Lore Becker Andrew Blake Debra Brooker Heather Cater Marie-France Champy Roy Combe Petr Danecek Armida di Fenza Hilary Gates Anna-Karin Gerdin Elisabetta Golini John M Hancock Wolfgang Hans Sabine M Hölter Tertius Hough Pierre Jurdic Thomas M Keane Hugh Morgan Werner Müller Frauke Neff George Nicholson Bastian Pasche Laura-Anne Roberson Jan Rozman Mark Sanderson Luis Santos Mohammed Selloum Carl Shannon Anne Southwell Glauco P Tocchini-Valentini Valerie E Vancollie Henrik Westerberg Wolfgang Wurst Min Zi Binnaz Yalcin Ramiro Ramirez-Solis Karen P Steel Ann-Marie Mallon Martin Hrabě de Angelis Yann Herault Steve D M Brown

Genome Biol 2013 Jul 31;14(7):R82. Epub 2013 Jul 31.

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http://dx.doi.org/10.1186/gb-2013-14-7-r82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053787PMC
July 2013

Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project.

Authors:
Abdel Ayadi Marie-Christine Birling Joanna Bottomley James Bussell Helmut Fuchs Martin Fray Valérie Gailus-Durner Simon Greenaway Richard Houghton Natasha Karp Sophie Leblanc Christoph Lengger Holger Maier Ann-Marie Mallon Susan Marschall David Melvin Hugh Morgan Guillaume Pavlovic Ed Ryder William C Skarnes Mohammed Selloum Ramiro Ramirez-Solis Tania Sorg Lydia Teboul Laurent Vasseur Alison Walling Tom Weaver Sara Wells Jacqui K White Allan Bradley David J Adams Karen P Steel Martin Hrabě de Angelis Steve D Brown Yann Herault

Mamm Genome 2012 Oct 9;23(9-10):600-10. Epub 2012 Sep 9.

Institut Clinique de la Souris, PHENOMIN, IGBMC/ICS-MCI, CNRS, INSERM, Université de Strasbourg, UMR7104, UMR964, 1 rue Laurent Fries, 67404 Illkirch, France.

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http://dx.doi.org/10.1007/s00335-012-9418-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463797PMC
October 2012

The mammalian gene function resource: the International Knockout Mouse Consortium.

Authors:
Allan Bradley Konstantinos Anastassiadis Abdelkader Ayadi James F Battey Cindy Bell Marie-Christine Birling Joanna Bottomley Steve D Brown Antje Bürger Carol J Bult Wendy Bushell Francis S Collins Christian Desaintes Brendan Doe Aris Economides Janan T Eppig Richard H Finnell Colin Fletcher Martin Fray David Frendewey Roland H Friedel Frank G Grosveld Jens Hansen Yann Hérault Geoffrey Hicks Andreas Hörlein Richard Houghton Martin Hrabé de Angelis Danny Huylebroeck Vivek Iyer Pieter J de Jong James A Kadin Cornelia Kaloff Karen Kennedy Manousos Koutsourakis K C Kent Lloyd Susan Marschall Jeremy Mason Colin McKerlie Michael P McLeod Harald von Melchner Mark Moore Alejandro O Mujica Andras Nagy Mikhail Nefedov Lauryl M Nutter Guillaume Pavlovic Jane L Peterson Jonathan Pollock Ramiro Ramirez-Solis Derrick E Rancourt Marcello Raspa Jacques E Remacle Martin Ringwald Barry Rosen Nadia Rosenthal Janet Rossant Patricia Ruiz Noppinger Ed Ryder Joel Zupicich Schick Frank Schnütgen Paul Schofield Claudia Seisenberger Mohammed Selloum Elizabeth M Simpson William C Skarnes Damian Smedley William L Stanford A Francis Stewart Kevin Stone Kate Swan Hamsa Tadepally Lydia Teboul Glauco P Tocchini-Valentini David Valenzuela Anthony P West Ken-ichi Yamamura Yuko Yoshinaga Wolfgang Wurst

Mamm Genome 2012 Oct 12;23(9-10):580-6. Epub 2012 Sep 12.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

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http://dx.doi.org/10.1007/s00335-012-9422-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463800PMC
October 2012

The in vivo Down syndrome genomic library in mouse.

Authors:
Yann Herault Arnaud Duchon Emilie Velot Damien Maréchal Véronique Brault

Prog Brain Res 2012 ;197:169-97

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Translational medicine and Neurogenetics program, IGBMC, CNRS, INSERM, Université de Strasbourg, UMR7104, UMR964, Illkirch, Strasbourg, France.

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http://dx.doi.org/10.1016/B978-0-444-54299-1.00009-1DOI Listing
September 2012

Missense mutation in the second RNA binding domain reveals a role for Prkra (PACT/RAX) during skull development.

Authors:
Benjamin K Dickerman Christine L White Claire Chevalier Valérie Nalesso Cyril Charles Sophie Fouchécourt Florian Guillou Laurent Viriot Ganes C Sen Yann Hérault

PLoS One 2011 14;6(12):e28537. Epub 2011 Dec 14.

Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028537PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237451PMC
August 2012

Highly-efficient, fluorescent, locus directed cre and FlpO deleter mice on a pure C57BL/6N genetic background.

Authors:
Marie-Christine Birling Andrée Dierich Sylvie Jacquot Yann Hérault Guillaume Pavlovic

Genesis 2012 Jun 20;50(6):482-9. Epub 2012 Mar 20.

Institut Clinique de la Souris, ICS, 1 rue Laurent Fries, 67404 Illkirch, France.

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http://dx.doi.org/10.1002/dvg.20826DOI Listing
June 2012

The App-Runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a Down syndrome mouse model.

Authors:
Matthieu Raveau Jacques M Lignon Valérie Nalesso Arnaud Duchon Yoram Groner Andrew J Sharp Doulaye Dembele Véronique Brault Yann Hérault

PLoS Genet 2012 May 31;8(5):e1002724. Epub 2012 May 31.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Translational Medicine and Neurogenetics, CNRS, INSERM, Université de Strasbourg, UMR7104, UMR964, Illkirch, France.

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http://dx.doi.org/10.1371/journal.pgen.1002724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364940PMC
May 2012

Characterization of PTZ-induced seizure susceptibility in a down syndrome mouse model that overexpresses CSTB.

Authors:
Véronique Brault Benoît Martin Nathalie Costet Jean-Charles Bizot Yann Hérault

PLoS One 2011 30;6(11):e27845. Epub 2011 Nov 30.

Department of Translational Medicine and Neurogenetics, Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC), Inserm U596, CNRS UMR7104, Université de Strasbourg, Illkirch, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027845PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227573PMC
April 2012

DYRK1A: a master regulatory protein controlling brain growth.

Authors:
Fayçal Guedj Patricia Lopes Pereira Sonia Najas Maria-Jose Barallobre Caroline Chabert Benoit Souchet Catherine Sebrie Catherine Verney Yann Herault Mariona Arbones Jean M Delabar

Neurobiol Dis 2012 Apr 26;46(1):190-203. Epub 2012 Jan 26.

Univ Paris Diderot, Sorbonne Paris Cité, Adaptive Functional Biology, EAC CNRS 4413, 75205 Paris, France.

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http://dx.doi.org/10.1016/j.nbd.2012.01.007DOI Listing
April 2012

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome.

Authors:
Arnaud Duchon Matthieu Raveau Claire Chevalier Valérie Nalesso Andrew J Sharp Yann Herault

Mamm Genome 2011 Dec 28;22(11-12):674-84. Epub 2011 Sep 28.

Institut de Génétique Biologie Moléculaire et Cellulaire, Translational Medicine and Neuroscience Program, Université de Strasbourg, Illkirch, France.

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http://dx.doi.org/10.1007/s00335-011-9356-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224224PMC
December 2011

Prmt2 regulates the lipopolysaccharide-induced responses in lungs and macrophages.

Authors:
Emilie Dalloneau Patricia Lopes Pereira Véronique Brault Elizabeth G Nabel Yann Hérault

J Immunol 2011 Nov 28;187(9):4826-34. Epub 2011 Sep 28.

Centre National de la Recherche Scientifique, Institut de Génétique Biologie Moléculaire et Cellulaire, INSERM, Université de Strasbourg, Unité Mixte de Recherche 7104, 67404 Illkirch, France.

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http://dx.doi.org/10.4049/jimmunol.1101087DOI Listing
November 2011

PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-δ activation in mouse models of Down syndrome.

Authors:
François Mouton-Liger Sophie Thomas Revital Rattenbach Laetitia Magnol Vanessa Larigaldie Aurelie Ledru Yann Herault Catherine Verney Nicole Créau

J Comp Neurol 2011 Oct;519(14):2779-802

Functional Adaptive Biology (BFA), Centre National de la Recherche Scientifique (CNRS) EAC4413, Université Paris Diderot-Paris7, 75205 Paris Cedex 13, France.

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http://dx.doi.org/10.1002/cne.22651DOI Listing
October 2011

The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome.

Authors:
Arnaud Duchon Stéphanie Pothion Véronique Brault Andrew J Sharp Victor L J Tybulewicz Elizabeth M C Fisher Yann Herault

Behav Brain Res 2011 Mar 31;217(2):271-81. Epub 2010 Oct 31.

Institut de Génétique Biologie Moléculaire et Cellulaire, Université de Strasbourg, Illkirch, France.

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http://dx.doi.org/10.1016/j.bbr.2010.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590452PMC
March 2011

Standardized Post-Mortem Examination and Fixation Procedures for Mutant and Treated Mice.

Authors:
Cristina Antal Stéphanie Muller Olivia Wendling Yann Hérault Manuel Mark

Curr Protoc Mouse Biol 2011 Mar 1;1(1):17-53. Epub 2011 Mar 1.

Mouse Clinical Institute, Illkirch, France.

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http://dx.doi.org/10.1002/9780470942390.mo100118DOI Listing
March 2011

Down syndrome: from understanding the neurobiology to therapy.

Authors:
Katheleen Gardiner Yann Herault Ira T Lott Stylianos E Antonarakis Roger H Reeves Mara Dierssen

J Neurosci 2010 Nov;30(45):14943-5

Department of Pediatrics, Intellectual and Developmental Disabilities Research Center, University of Colorado Denver, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.3728-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842485PMC
November 2010

Controlled somatic and germline copy number variation in the mouse model.

Authors:
Yann Hérault Arnaud Duchon Damien Maréchal Matthieu Raveau Patricia L Pereira Emilie Dalloneau Véronique Brault

Curr Genomics 2010 Sep;11(6):470-80

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U964, CNRS UMR7104, Université de Strasbourg, Illkirch, France.

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http://dx.doi.org/10.2174/138920210793176038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018727PMC
September 2010

EMMA--mouse mutant resources for the international scientific community.

Authors:
Phil Wilkinson Jitka Sengerova Raffaele Matteoni Chao-Kung Chen Gaetan Soulat Abel Ureta-Vidal Sabine Fessele Michael Hagn Marzia Massimi Karen Pickford Richard H Butler Susan Marschall Ann-Marie Mallon Amanda Pickard Marcello Raspa Ferdinando Scavizzi Martin Fray Vanessa Larrigaldie Johan Leyritz Ewan Birney Glauco P Tocchini-Valentini Steve Brown Yann Herault Lluis Montoliu Martin Hrabé de Angelis Damian Smedley

Nucleic Acids Res 2010 Jan 26;38(Database issue):D570-6. Epub 2009 Sep 26.

European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

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http://dx.doi.org/10.1093/nar/gkp799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808872PMC
January 2010

A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome.

Authors:
Patricia Lopes Pereira Laetitia Magnol Ignasi Sahún Véronique Brault Arnaud Duchon Paola Prandini Agnès Gruart Jean-Charles Bizot Bernadette Chadefaux-Vekemans Samuel Deutsch Fabrice Trovero José María Delgado-García Stylianos E Antonarakis Mara Dierssen Yann Herault

Hum Mol Genet 2009 Dec 26;18(24):4756-69. Epub 2009 Sep 26.

Molecular Embryology and Immunology, Université d'Orléans, UMR6218, Orléans Cedex 2, France.

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http://dx.doi.org/10.1093/hmg/ddp438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778371PMC
December 2009

Proliferation deficits and gene expression dysregulation in Down's syndrome (Ts1Cje) neural progenitor cells cultured from neurospheres.

Authors:
Randal X Moldrich Luce Dauphinot Julien Laffaire Tania Vitalis Yann Hérault Philip M Beart Jean Rossier Denis Vivien Corinne Gehrig Stylianos E Antonarakis Robert Lyle Marie-Claude Potier

J Neurosci Res 2009 Nov;87(14):3143-52

Laboratoire de Neurobiologie et Diversité Cellulaire, CNRS UMR7637, ESPCI, Paris, France.

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http://dx.doi.org/10.1002/jnr.22131DOI Listing
November 2009

DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase.

Authors:
Christophe Noll Chris Planque Clémentine Ripoll Fayçal Guedj Anna Diez Véronique Ducros Nicole Belin Arnaud Duchon Jean-Louis Paul Anne Badel Bénédicte de Freminville Yann Grattau Henri Bléhaut Yann Herault Nathalie Janel Jean-Maurice Delabar

PLoS One 2009 Oct 21;4(10):e7540. Epub 2009 Oct 21.

University Paris Diderot-CNRS EAC 4413, Unit of Functional and Adaptive Biology, Paris, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007540PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760102PMC
October 2009

Fork stalling and template switching as a mechanism for polyalanine tract expansion affecting the DYC mutant of HOXD13, a new murine model of synpolydactyly.

Authors:
Olivier Cocquempot Véronique Brault Charles Babinet Yann Herault

Genetics 2009 Sep 22;183(1):23-30. Epub 2009 Jun 22.

Université d'Orléans, UMR6218, Molecular Immunology and Embryology, 45071 Orléans, France.

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http://dx.doi.org/10.1534/genetics.109.104695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746147PMC
September 2009

Aneuploidy: from a physiological mechanism of variance to Down syndrome.

Authors:
Mara Dierssen Yann Herault Xavier Estivill

Physiol Rev 2009 Jul;89(3):887-920

Genes and Disease Program, Genomic Regulation Center-CRG, Pompeu Fabra University, Barcelona Biomedical Research Park, Dr Aiguader 88, PRBB building E, Barcelona 08003, Catalonia, Spain.

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http://dx.doi.org/10.1152/physrev.00032.2007DOI Listing
July 2009

Heme oxygenase-1 accelerates cutaneous wound healing in mice.

Authors:
Anna Grochot-Przeczek Radoslaw Lach Jacek Mis Klaudia Skrzypek Malgorzata Gozdecka Patrycja Sroczynska Milena Dubiel Andrzej Rutkowski Magdalena Kozakowska Anna Zagorska Jacek Walczynski Halina Was Jerzy Kotlinowski Justyna Drukala Krzysztof Kurowski Claudine Kieda Yann Herault Jozef Dulak Alicja Jozkowicz

PLoS One 2009 Jun 4;4(6):e5803. Epub 2009 Jun 4.

Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005803PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686151PMC
June 2009