Yann Herault

Yann Herault

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Yann Herault

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Oligogenic Effects of 16p11.2 Copy-Number Variation on Craniofacial Development.

Cell Rep 2019 Sep;28(13):3320-3328.e4

Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA; Beyster Center for Genomics of Psychiatric Diseases, University of California, San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.08.071DOI Listing
September 2019

Genetic quality assurance and genetic monitoring of laboratory mice and rats: FELASA Working Group Report.

Lab Anim 2019 Aug 20:23677219867719. Epub 2019 Aug 20.

10 Institute of Laboratory Animal Science, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1177/0023677219867719DOI Listing
August 2019

Ultrasound-Guided Approaches to Improve Orthotopic Mouse Xenograft Models for Hepatocellular Carcinoma.

Curr Protoc Mouse Biol 2019 Jun 30;9(2):e62. Epub 2019 May 30.

Institut Clinique de la Souris, PHENOMIN-ICS, Illkirch, France.

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http://dx.doi.org/10.1002/cpmo.62DOI Listing
June 2019

Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts.

Commun Biol 2019 7;2:97. Epub 2019 Mar 7.

27Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis, Sacramento, CA 95817 USA.

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http://dx.doi.org/10.1038/s42003-019-0349-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405960PMC
March 2019

Hepatocyte SHP deficiency protects mice from acetaminophen-evoked liver injury in a JNK-signaling regulation and GADD45β-dependent manner.

Arch Toxicol 2018 08 25;92(8):2563-2572. Epub 2018 Jun 25.

Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, South Korea.

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http://dx.doi.org/10.1007/s00204-018-2247-3DOI Listing
August 2018

Synaptic dysfunction in amygdala in intellectual disorder models.

Prog Neuropsychopharmacol Biol Psychiatry 2018 06 1;84(Pt B):392-397. Epub 2017 Aug 1.

Team "synapse in cognition", UMR 5297, University of Bordeaux, Bordeaux, France; Team "synapse in cognition", UMR 5297, Centre National de la recherche scientifique, Bordeaux, France. Electronic address:

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http://dx.doi.org/10.1016/j.pnpbp.2017.07.028DOI Listing
June 2018

Translating molecular advances in Down syndrome and Fragile X syndrome into therapies.

Eur Neuropsychopharmacol 2018 06 7;28(6):675-690. Epub 2018 Jun 7.

Institut du Cerveau et de la Moelle épinière, CNRS UMR7225, INSERM U1127, UPMC, Hôpital de la Pitié-Salpêtrière, 47 Bd de l'Hôpital, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2018.03.006DOI Listing
June 2018

A Population Study of Common Ocular Abnormalities in C57BL/6N rd8 Mice.

Invest Ophthalmol Vis Sci 2018 05;59(6):2252-2261

Department of Ophthalmology & Vision Science, School of Medicine, University of California-Davis, Sacramento, California, United States.

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http://dx.doi.org/10.1167/iovs.17-23513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935295PMC
May 2018

Nox4 genetic inhibition in experimental hypertension and metabolic syndrome.

Arch Cardiovasc Dis 2018 Jan 4;111(1):41-52. Epub 2017 Nov 4.

Institut clinique de la Souris, institut de génétique et de biologie moléculaire et cellulaire, université de Strasbourg, Illkirch, France; Laboratoire de neurobiologie et pharmacologie cardiovasculaire, faculté de médecine, fédération de médecine translationnelle, université, CHU de Strasbourg, 11, rue Humann, 67085 Strasbourg cedex, France. Electronic address:

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http://dx.doi.org/10.1016/j.acvd.2017.03.011DOI Listing
January 2018

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.

Nat Commun 2018 01 18;9(1):288. Epub 2018 Jan 18.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1038/s41467-017-01995-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773596PMC
January 2018

Integrated transcriptional analysis unveils the dynamics of cellular differentiation in the developing mouse hippocampus.

Sci Rep 2017 12 22;7(1):18073. Epub 2017 Dec 22.

Radboud University, Department of Molecular Biology, Faculty of Science, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-18287-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741714PMC
December 2017

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.

Expert Opin Ther Pat 2017 Nov 2;27(11):1183-1199. Epub 2017 Aug 2.

f Normandie Univ , UNIROUEN, INSA Rouen, CNRS, COBRA UMR 6014 , Rouen , France.

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http://dx.doi.org/10.1080/13543776.2017.1360285DOI Listing
November 2017

Corrigendum: High-throughput discovery of novel developmental phenotypes.

Nature 2017 11 8;551(7680):398. Epub 2017 Nov 8.

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http://dx.doi.org/10.1038/nature24643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849394PMC
November 2017

Rodent models in Down syndrome research: impact and future opportunities.

Dis Model Mech 2017 10;10(10):1165-1186

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, 1 rue Laurent Fries, 67404 Illkirch, France.

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http://dx.doi.org/10.1242/dmm.029728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665454PMC
October 2017

Modeling human disease in rodents by CRISPR/Cas9 genome editing.

Mamm Genome 2017 08 4;28(7-8):291-301. Epub 2017 Jul 4.

CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France.

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http://dx.doi.org/10.1007/s00335-017-9703-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569124PMC
August 2017

Introduction to Mammalian Genome Special Issue: Genome Editing.

Mamm Genome 2017 08;28(7-8):235-236

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK.

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http://dx.doi.org/10.1007/s00335-017-9708-5DOI Listing
August 2017

Atp6ap2 ablation in adult mice impairs viability through multiple organ deficiencies.

Sci Rep 2017 08 29;7(1):9618. Epub 2017 Aug 29.

CELPHEDIA-PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, F-67404, Illkirch-Graffenstaden, France.

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http://dx.doi.org/10.1038/s41598-017-08845-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575319PMC
August 2017

A Fast, Easy, and Customizable Eight-Color Flow Cytometric Method for Analysis of the Cellular Content of Bronchoalveolar Lavage Fluid in the Mouse.

Curr Protoc Mouse Biol 2017 Jun 19;7(2):88-99. Epub 2017 Jun 19.

Laboratoire d'Innovation Thérapeutique, Faculté de Pharmacie, Université de Strasbourg, Illkirch, France.

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http://dx.doi.org/10.1002/cpmo.26DOI Listing
June 2017

Efficient and rapid generation of large genomic variants in rats and mice using CRISMERE.

Sci Rep 2017 03 7;7:43331. Epub 2017 Mar 7.

PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, F-67404 Illkirch-Graffenstaden, France.

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http://dx.doi.org/10.1038/srep43331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339700PMC
March 2017

The DNA methyltransferase DNMT3C protects male germ cells from transposon activity.

Science 2016 11;354(6314):909-912

Institut Curie, PSL Research University, INSERM, CNRS, 75005 Paris, France.

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http://dx.doi.org/10.1126/science.aah5143DOI Listing
November 2016

E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis.

Proc Natl Acad Sci U S A 2016 09 12;113(39):11004-9. Epub 2016 Sep 12.

Institut de Recherche en Cancérologie de Montpellier, Montpellier F-34298, France; INSERM U1194, Montpellier F-34298, France; University of Montpellier, Montpellier F-34090, France; Institut Régional du Cancer de Montpellier, Montpellier F-34298, France; Equipe labellisée Ligue Contre le Cancer, 75013 Paris, France;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047149PMC
http://dx.doi.org/10.1073/pnas.1602751113DOI Listing
September 2016

High-throughput discovery of novel developmental phenotypes.

Nature 2016 09 14;537(7621):508-514. Epub 2016 Sep 14.

The Jackson Laboratory, Bar Harbor, Maine 04609, USA.

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http://dx.doi.org/10.1038/nature19356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295821PMC
September 2016

A suppressor locus for MODY3-diabetes.

Sci Rep 2016 Sep 26;6:33087. Epub 2016 Sep 26.

Laboratoire d' Expression Génique, Développement et Maladies (EGDM), Département Développement, Reproduction et Cancer, INSERM U1016, Institut Cochin, Paris, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036084PMC
http://dx.doi.org/10.1038/srep33087DOI Listing
September 2016

DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome.

Front Behav Neurosci 2016 3;10:104. Epub 2016 Jun 3.

Department of Translational Medicine and Neurogenetics, Institut de Génétique et de Biologie Moléculaire et CellulaireIllkirch, France; UMR7104, Centre National de la Recherche ScientifiqueIllkirch, France; U964, Institut National de la Santé et de la Recherche MédicaleIllkirch, France; Université de StrasbourgIllkirch, France; PHENOMIN, Institut Clinique de la Souris, Groupement d'Intérêt Économique-Centre Européen de Recherche en Biologie et en Médecine, CNRS, INSERMIllkirch-Graffenstaden, France.

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http://dx.doi.org/10.3389/fnbeh.2016.00104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891327PMC
July 2016

Altered microtubule dynamics and vesicular transport in mouse and human MeCP2-deficient astrocytes.

Hum Mol Genet 2016 Jan 24;25(1):146-57. Epub 2015 Nov 24.

Inserm, U1016, Institut Cochin, Paris, France, Cnrs, UMR8104, Paris, France, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, Laboratoire de Biologie et Génétique Moléculaires, HUPC, Hôpital Cochin, Paris, France,

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http://dx.doi.org/10.1093/hmg/ddv464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690499PMC
January 2016

Dyrk1A induces pancreatic β cell mass expansion and improves glucose tolerance.

Cell Cycle 2014 28;13(14):2221-9. Epub 2014 May 28.

INSERM U1016; Institut Cochin; Faculté de Médecine Cochin; Université Paris Descartes; Paris, France.

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http://dx.doi.org/10.4161/cc.29250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111677PMC
December 2015

Dosage of the Abcg1-U2af1 region modifies locomotor and cognitive deficits observed in the Tc1 mouse model of Down syndrome.

PLoS One 2015 23;10(2):e0115302. Epub 2015 Feb 23.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, 1 rue Laurent Fries, 67404 Illkirch, France; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France; Université de Strasbourg, Illkirch, France; Institut Clinique de la Souris, ICS, 1 rue Laurent Fries, 67404 Illkirch, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115302PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338106PMC
December 2015

Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration.

Hum Mol Genet 2015 Dec 16;24(23):6736-55. Epub 2015 Sep 16.

Institut Clinique de la Souris, PHENOMIN, GIE CERBM, 1 rue Laurent Fries, 67404 Illkirch, France, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France, Centre National de la Recherche Scientifique, UMR7104, Illkirch, France, Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France and Université de Strasbourg, Illkirch, France

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http://dx.doi.org/10.1093/hmg/ddv380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634377PMC
December 2015

Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models.

Front Behav Neurosci 2015 20;9:267. Epub 2015 Oct 20.

Université Paris Diderot, Sorbonne Paris Cité, Adaptive Functional Biology, UMR Centre National de la Recherche Scientifique 8251 Paris, France ; Université Pierre-et-Marie-Curie Paris, 06 UMR S 1127, Centre National de la Recherche Scientifique UMR 7225, Institut National de la Santé et de la Recherche Médicale, U 1127, Sorbonne Universités, Institut du Cerveau et de la Moelle Epiniere Paris, France.

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http://dx.doi.org/10.3389/fnbeh.2015.00267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611057PMC
November 2015

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

Authors:
Martin Hrabě de Angelis George Nicholson Mohammed Selloum Jacqui White Hugh Morgan Ramiro Ramirez-Solis Tania Sorg Sara Wells Helmut Fuchs Martin Fray David J Adams Niels C Adams Thure Adler Antonio Aguilar-Pimentel Dalila Ali-Hadji Gregory Amann Philippe André Sarah Atkins Aurelie Auburtin Abdel Ayadi Julien Becker Lore Becker Elodie Bedu Raffi Bekeredjian Marie-Christine Birling Andrew Blake Joanna Bottomley Mike Bowl Véronique Brault Dirk H Busch James N Bussell Julia Calzada-Wack Heather Cater Marie-France Champy Philippe Charles Claire Chevalier Francesco Chiani Gemma F Codner Roy Combe Roger Cox Emilie Dalloneau André Dierich Armida Di Fenza Brendan Doe Arnaud Duchon Oliver Eickelberg Chris T Esapa Lahcen El Fertak Tanja Feigel Irina Emelyanova Jeanne Estabel Jack Favor Ann Flenniken Alessia Gambadoro Lilian Garrett Hilary Gates Anna-Karin Gerdin George Gkoutos Simon Greenaway Lisa Glasl Patrice Goetz Isabelle Goncalves Da Cruz Alexander Götz Jochen Graw Alain Guimond Wolfgang Hans Geoff Hicks Sabine M Hölter Heinz Höfler John M Hancock Robert Hoehndorf Tertius Hough Richard Houghton Anja Hurt Boris Ivandic Hughes Jacobs Sylvie Jacquot Nora Jones Natasha A Karp Hugo A Katus Sharon Kitchen Tanja Klein-Rodewald Martin Klingenspor Thomas Klopstock Valerie Lalanne Sophie Leblanc Christoph Lengger Elise le Marchand Tonia Ludwig Aline Lux Colin McKerlie Holger Maier Jean-Louis Mandel Susan Marschall Manuel Mark David G Melvin Hamid Meziane Kateryna Micklich Christophe Mittelhauser Laurent Monassier David Moulaert Stéphanie Muller Beatrix Naton Frauke Neff Patrick M Nolan Lauryl Mj Nutter Markus Ollert Guillaume Pavlovic Natalia S Pellegata Emilie Peter Benoit Petit-Demoulière Amanda Pickard Christine Podrini Paul Potter Laurent Pouilly Oliver Puk David Richardson Stephane Rousseau Leticia Quintanilla-Fend Mohamed M Quwailid Ildiko Racz Birgit Rathkolb Fabrice Riet Janet Rossant Michel Roux Jan Rozman Ed Ryder Jennifer Salisbury Luis Santos Karl-Heinz Schäble Evelyn Schiller Anja Schrewe Holger Schulz Ralf Steinkamp Michelle Simon Michelle Stewart Claudia Stöger Tobias Stöger Minxuan Sun David Sunter Lydia Teboul Isabelle Tilly Glauco P Tocchini-Valentini Monica Tost Irina Treise Laurent Vasseur Emilie Velot Daniela Vogt-Weisenhorn Christelle Wagner Alison Walling Bruno Weber Olivia Wendling Henrik Westerberg Monja Willershäuser Eckhard Wolf Anne Wolter Joe Wood Wolfgang Wurst Ali Önder Yildirim Ramona Zeh Andreas Zimmer Annemarie Zimprich Chris Holmes Karen P Steel Yann Herault Valérie Gailus-Durner Ann-Marie Mallon Steve Dm Brown

Nat Genet 2015 Sep 27;47(9):969-978. Epub 2015 Jul 27.

MRC Harwell, Medical Research Council, Harwell, UK.

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http://dx.doi.org/10.1038/ng.3360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564951PMC
September 2015

Deletion of the App-Runx1 region in mice models human partial monosomy 21.

Dis Model Mech 2015 Jun 16;8(6):623-34. Epub 2015 Apr 16.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Translational Medicine and Neurogenetics, 1 rue Laurent Fries, Illkirch 67404, France Centre National de la Recherche Scientifique, UMR7104, Illkirch 67404, France Institut National de la Santé et de la Recherche Médicale, U964, Illkirch 67404, France Université de Strasbourg, Illkirch 67404, France Institut Clinique de la Souris, PHENOMIN-ICS, CNRS, INSERM, Université de Strasbourg, 1 rue Laurent Fries, Illkirch 67404, France

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http://dx.doi.org/10.1242/dmm.017814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457029PMC
June 2015

Opposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal Hspa13-App region.

PLoS Genet 2015 Mar 24;11(3):e1005062. Epub 2015 Mar 24.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France; Université de Strasbourg, Illkirch, France; Institut Clinique de la Souris, PHENOMIN, GIE CERBM, Illkirch, France.

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http://dx.doi.org/10.1371/journal.pgen.1005062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372517PMC
March 2015

Heterozygous deletion of the Williams-Beuren syndrome critical interval in mice recapitulates most features of the human disorder.

Hum Mol Genet 2014 Dec 15;23(24):6481-94. Epub 2014 Jul 15.

Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Spain, Neurosciences Program, Institut Hospital del Mar D'Investigacions Mèdiques (IMIM), Barcelona 08003, Spain,

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http://dx.doi.org/10.1093/hmg/ddu368DOI Listing
December 2014

Targeted deletion of kidney glucose-6 phosphatase leads to nephropathy.

Kidney Int 2014 Oct 9;86(4):747-56. Epub 2014 Apr 9.

1] Institut National de la Santé et de la Recherche Médicale, U855, Lyon, France [2] Université de Lyon, Lyon, France [3] Université Lyon 1, Villeurbanne, France.

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http://dx.doi.org/10.1038/ki.2014.102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678048PMC
October 2014

Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage.

Neurobiol Dis 2014 Sep 4;69:65-75. Epub 2014 May 4.

Univ Paris Diderot, Sorbonne Paris Cité, Adaptive Functional Biology, UMR CNRS 8251, 75205 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.04.016DOI Listing
September 2014

Cognition and hippocampal plasticity in the mouse is altered by monosomy of a genomic region implicated in Down syndrome.

Genetics 2014 Jul 21;197(3):899-912. Epub 2014 Apr 21.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, 67404 Illkirch, France Centre National de la Recherche Scientifique, UMR7104, Illkirch, France Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France Université de Strasbourg, 67400 Illkirch, France Institut Clinique de la Souris, PHENOMIN, Groupement d'Intérêt Economique Centre Européen de Recherche en Biologie Moléculaire, 67404 Illkirch, France

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http://dx.doi.org/10.1534/genetics.114.165241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096369PMC
July 2014

Skin progenitor cells contribute to bleomycin-induced skin fibrosis.

Arthritis Rheumatol 2014 Mar;66(3):707-13

Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1002/art.38276DOI Listing
March 2014

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans.

Mol Nutr Food Res 2014 Feb 14;58(2):278-88. Epub 2013 Sep 14.

Human Pharmacology and Clinical Neurosciences Research Group-Neurosciences Program, IMIM-Hospital del Mar Research Institute, Barcelona, Spain; Cardiovascular Risk and Nutrition Research Group-Inflammatory and Cardiovascular Disorders Program, IMIM-Hospital del Mar Research Institute, and CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Barcelona, Spain; University Pompeu Fabra, CEXS-UPF, Barcelona, Spain.

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http://dx.doi.org/10.1002/mnfr.201300325DOI Listing
February 2014

Surveying the Down syndrome mouse model resource identifies critical regions responsible for chronic otitis media.

Mamm Genome 2013 Dec 26;24(11-12):439-45. Epub 2013 Sep 26.

Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Room 6607 Level 6, Headley Way, Oxford, OX3 9DU, UK,

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http://dx.doi.org/10.1007/s00335-013-9475-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843744PMC
December 2013

DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels.

Mol Genet Metab 2013 Nov 20;110(3):371-7. Epub 2013 Jul 20.

Université Paris Diderot, Sorbonne Paris Cité, Unit of Functional and Adaptive Biology (BFA), EAC-CNRS 4413, Case 7104, 75205 Paris cedex 13, France.

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http://dx.doi.org/10.1016/j.ymgme.2013.07.014DOI Listing
November 2013

The homeodomain factor Gbx1 is required for locomotion and cell specification in the dorsal spinal cord.

PeerJ 2013 29;1:e142. Epub 2013 Aug 29.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Université de Strasbourg, Illkirch Cedex, France.

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http://dx.doi.org/10.7717/peerj.142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757465PMC
September 2013

The mammalian gene function resource: the International Knockout Mouse Consortium.

Mamm Genome 2012 Oct 12;23(9-10):580-6. Epub 2012 Sep 12.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

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http://dx.doi.org/10.1007/s00335-012-9422-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463800PMC
October 2012

The in vivo Down syndrome genomic library in mouse.

Prog Brain Res 2012 ;197:169-97

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Translational medicine and Neurogenetics program, IGBMC, CNRS, INSERM, Université de Strasbourg, UMR7104, UMR964, Illkirch, Strasbourg, France.

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http://dx.doi.org/10.1016/B978-0-444-54299-1.00009-1DOI Listing
September 2012

Highly-efficient, fluorescent, locus directed cre and FlpO deleter mice on a pure C57BL/6N genetic background.

Genesis 2012 Jun 20;50(6):482-9. Epub 2012 Mar 20.

Institut Clinique de la Souris, ICS, 1 rue Laurent Fries, 67404 Illkirch, France.

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http://dx.doi.org/10.1002/dvg.20826DOI Listing
June 2012

The App-Runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a Down syndrome mouse model.

PLoS Genet 2012 May 31;8(5):e1002724. Epub 2012 May 31.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Translational Medicine and Neurogenetics, CNRS, INSERM, Université de Strasbourg, UMR7104, UMR964, Illkirch, France.

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http://dx.doi.org/10.1371/journal.pgen.1002724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364940PMC
May 2012

Characterization of PTZ-induced seizure susceptibility in a down syndrome mouse model that overexpresses CSTB.

PLoS One 2011 30;6(11):e27845. Epub 2011 Nov 30.

Department of Translational Medicine and Neurogenetics, Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC), Inserm U596, CNRS UMR7104, Université de Strasbourg, Illkirch, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027845PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227573PMC
April 2012

DYRK1A: a master regulatory protein controlling brain growth.

Neurobiol Dis 2012 Apr 26;46(1):190-203. Epub 2012 Jan 26.

Univ Paris Diderot, Sorbonne Paris Cité, Adaptive Functional Biology, EAC CNRS 4413, 75205 Paris, France.

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http://dx.doi.org/10.1016/j.nbd.2012.01.007DOI Listing
April 2012

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome.

Mamm Genome 2011 Dec 28;22(11-12):674-84. Epub 2011 Sep 28.

Institut de Génétique Biologie Moléculaire et Cellulaire, Translational Medicine and Neuroscience Program, Université de Strasbourg, Illkirch, France.

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http://dx.doi.org/10.1007/s00335-011-9356-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224224PMC
December 2011

Prmt2 regulates the lipopolysaccharide-induced responses in lungs and macrophages.

J Immunol 2011 Nov 28;187(9):4826-34. Epub 2011 Sep 28.

Centre National de la Recherche Scientifique, Institut de Génétique Biologie Moléculaire et Cellulaire, INSERM, Université de Strasbourg, Unité Mixte de Recherche 7104, 67404 Illkirch, France.

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http://dx.doi.org/10.4049/jimmunol.1101087DOI Listing
November 2011

PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-δ activation in mouse models of Down syndrome.

J Comp Neurol 2011 Oct;519(14):2779-802

Functional Adaptive Biology (BFA), Centre National de la Recherche Scientifique (CNRS) EAC4413, Université Paris Diderot-Paris7, 75205 Paris Cedex 13, France.

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http://dx.doi.org/10.1002/cne.22651DOI Listing
October 2011

Standardized Post-Mortem Examination and Fixation Procedures for Mutant and Treated Mice.

Curr Protoc Mouse Biol 2011 Mar 1;1(1):17-53. Epub 2011 Mar 1.

Mouse Clinical Institute, Illkirch, France.

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http://dx.doi.org/10.1002/9780470942390.mo100118DOI Listing
March 2011

Down syndrome: from understanding the neurobiology to therapy.

J Neurosci 2010 Nov;30(45):14943-5

Department of Pediatrics, Intellectual and Developmental Disabilities Research Center, University of Colorado Denver, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.3728-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842485PMC
November 2010

Controlled somatic and germline copy number variation in the mouse model.

Curr Genomics 2010 Sep;11(6):470-80

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U964, CNRS UMR7104, Université de Strasbourg, Illkirch, France.

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http://dx.doi.org/10.2174/138920210793176038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018727PMC
September 2010

Fork stalling and template switching as a mechanism for polyalanine tract expansion affecting the DYC mutant of HOXD13, a new murine model of synpolydactyly.

Genetics 2009 Sep 22;183(1):23-30. Epub 2009 Jun 22.

Université d'Orléans, UMR6218, Molecular Immunology and Embryology, 45071 Orléans, France.

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http://dx.doi.org/10.1534/genetics.109.104695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746147PMC
September 2009

Aneuploidy: from a physiological mechanism of variance to Down syndrome.

Physiol Rev 2009 Jul;89(3):887-920

Genes and Disease Program, Genomic Regulation Center-CRG, Pompeu Fabra University, Barcelona Biomedical Research Park, Dr Aiguader 88, PRBB building E, Barcelona 08003, Catalonia, Spain.

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http://dx.doi.org/10.1152/physrev.00032.2007DOI Listing
July 2009

Inducing segmental aneuploid mosaicism in the mouse through targeted asymmetric sister chromatid event of recombination.

Genetics 2008 Sep 30;180(1):51-9. Epub 2008 Aug 30.

Université d'Orléans, UMR6218, Molecular Immunology and Embryology, Orléans Cedex, France.

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http://dx.doi.org/10.1534/genetics.108.092312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2535701PMC
September 2008

Modeling the monosomy for the telomeric part of human chromosome 21 reveals haploinsufficient genes modulating the inflammatory and airway responses.

Hum Mol Genet 2007 Sep 25;16(17):2040-52. Epub 2007 Jun 25.

Institut de Tansgenose, Molecular Immunology and Embryology, Université Orléans, Férollerie, Orléans, France.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddm152DOI Listing
September 2007