Publications by authors named "Yanhua Cheng"

35 Publications

Smart fibers for energy conversion and storage.

Chem Soc Rev 2021 Jun;50(12):7009-7061

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.

Fibers have played a critical role in the long history of human development. They are the basic building blocks of textiles. Synthetic fibers not only make clothes stronger and more durable, but are also customizable and cheaper. The growth of miniature and wearable electronics has promoted the development of smart and multifunctional fibers. Particularly, the incorporation of functional semiconductors and electroactive materials in fibers has opened up the field of fiber electronics. The energy supply system is the key branch for fiber electronics. Herein, after a brief introduction on the history of smart and functional fibers, we review the current state of advanced functional fibers for their application in energy conversion and storage, focusing on nanogenerators, solar cells, supercapacitors and batteries. Subsequently, the importance of the integration of fiber-shaped energy conversion and storage devices via smart structure design is discussed. Finally, the challenges and future direction in this field are highlighted. Through this review, we hope to inspire scientists with different research backgrounds to enter this multi-disciplinary field to promote its prosperity and development and usher in a truly new era of smart fibers.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0cs01603aDOI Listing
June 2021

Enantiomeric Switching of the Circularly Polarized Luminescence Processes in a Hierarchical Biomimetic System by Film Tilting.

ACS Nano 2021 01 4;15(1):1397-1406. Epub 2020 Dec 4.

Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study and Development of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.

Circularly polarized luminescence (CPL) switching has attracted great attention due to the potential applications in chiral photonics and electronics. However, the lack of examples to achieve switchable CPL within a single material in the dry solid state hampers the scope of applications. Herein, we demonstrate a crystalline chiral polymer film as a polarizing medium consisting of radially assembled twisted crystallites, where achiral aggregation-induced emissive luminogens (AIEgens) are confined between the twisted crystalline stacks, eventually yielding handedness-switchable CPL by simple film tilting. Hierarchically organized twisted crystallites create the selective reflection activity of the polarizing medium. Upon film tilting, enantiomeric switching is realized by selectively collecting transmitted and reflected CPL components. The confined AIEgens in the crystalline polarizing system show a great enhancement of the luminescence efficiency. Moreover, the approach is general with broadband activity, and various AIEgens could be applied to generate full-color-tunable CPL. Additionally, the rigid and continuous nature of this polarizing system affords enhanced optical stability and facile modulation, developing a general route for designing chiroptical materials.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsnano.0c08665DOI Listing
January 2021

Integrated dynamic wet spinning of core-sheath hydrogel fibers for optical-to-brain/tissue communications.

Natl Sci Rev 2021 Sep 31;8(9):nwaa209. Epub 2020 Aug 31.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.

Hydrogel optical light-guides have received substantial interest for applications such as deep-tissue biosensors, optogenetic stimulation and photomedicine due to their biocompatibility, (micro)structure control and tissue-like Young's modulus. However, despite recent developments, large-scale fabrication with a continuous synthetic methodology, which could produce core-sheath hydrogel fibers with the desired optical and mechanical properties suitable for deep-tissue applications, has yet to be achieved. In this study, we report a versatile concept of integrated light-triggered dynamic wet spinning capable of continuously producing core-sheath hydrogel optical fibers with tunable fiber diameters, and mechanical and optical propagation properties. Furthermore, this concept also exhibited versatility for various kinds of core-sheath functional fibers. The wet spinning synthetic procedure and fabrication process were optimized with the rational design of the core/sheath material interface compatibility [core = poly(ethylene glycol diacrylate--acrylamide); sheath = Ca-alginate], optical transparency, refractive index and spinning solution viscosity. The resulting hydrogel optical fibers exhibited desirable low optical attenuation (0.18 ± 0.01 dB cm with 650 nm laser light), excellent biocompatibility and tissue-like Young's modulus (<2.60 MPa). The optical waveguide hydrogel fibers were successfully employed for deep-tissue cancer therapy and brain optogenetic stimulation, confirming that they could serve as an efficient versatile tool for diverse deep-tissue therapy and brain optogenetic applications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/nsr/nwaa209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433079PMC
September 2021

Solid-state intramolecular motions in continuous fibers driven by ambient humidity for fluorescent sensors.

Natl Sci Rev 2021 Apr 17;8(4):nwaa135. Epub 2020 Jun 17.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, International Joint Laboratory for Advanced Fiber and Low-Dimension Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.

One striking feature of molecular rotors is their ability to change conformation with detectable optical signals through molecular motion when stimulated. However, due to the strong intermolecular interactions, synthetic molecular rotors have often relied on fluid environments. Here, we take advantage of the solid-state intramolecular motion of aggregation-induced emission (AIE) molecular rotors and one-dimensional fibers, developing highly sensitive optical fiber sensors that respond to ambient humidity rapidly and reversibly with observable chromatic fluorescence change. Moisture environments induce the swelling of the polymer fibers, activating intramolecular motions of AIE molecules to result in red-shifted fluorescence and linear response to ambient humidity. In this case, polymer fiber provides a process-friendly architecture and a physically tunable medium for the embedded AIE molecules to manipulate their fluorescence response characteristics. Assembly of sensor fibers could be built into hierarchical structures, which are adaptive to diverse-configuration for spatial-temporal humidity mapping, and suitable for device integration to build light-emitting sensors as well as touchless positioning interfaces for intelligence systems.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/nsr/nwaa135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288334PMC
April 2021

Emission Control from Transition Metal Dichalcogenide Monolayers by Aggregation-Induced Molecular Rotors.

ACS Nano 2020 Jun 18;14(6):7444-7453. Epub 2020 May 18.

Research School of Electrical, Energy and Materials Engineering, College of Engineering and Computer Science, The Australian National University, Canberra, ACT 2601, Australia.

Organic-inorganic (O-I) heterostructures, consisting of atomically thin inorganic semiconductors and organic molecules, present synergistic and enhanced optoelectronic properties with a high tunability. Here, we develop a class of air-stable vertical O-I heterostructures comprising a monolayer of transition-metal dichalcogenides (TMDs), including WS, WSe, and MoSe, on top of tetraphenylethylene (TPE) core-based aggregation-induced emission (AIE) molecular rotors. The created O-I heterostructures yields a photoluminescence (PL) enhancement of up to ∼950%, ∼500%, and ∼330% in the top monolayer WS, MoSe, and WSe as compared to PL in their pristine monolayers, respectively. The strong PL enhancement is mainly attributed to the efficient photogenerated carrier process in the AIE luminogens (courtesy of their restricted intermolecular motions in the solid state) and the charge-transfer process in the created type I O-I heterostructures. Moreover, we observe an improvement in photovoltaic properties of the TMDs in the heterostructures including the quasi-Fermi level splitting, minority carrier lifetime, and light absorption. This work presents an inspiring example of combining stable, highly luminescent AIE-based molecules, with rich photochemistry and versatile applications, with atomically thin inorganic semiconductors for multifunctional and efficient optoelectronic devices.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsnano.0c03086DOI Listing
June 2020

Manipulating Solid-State Intramolecular Motion toward Controlled Fluorescence Patterns.

ACS Nano 2020 02 10;14(2):2090-2098. Epub 2020 Jan 10.

Department of Chemistry, The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute of Molecular Functional Materials, Division of Life Science and State Key Laboratory of Molecular Neuroscience , The Hong Kong University of Science and Technology , Clear Water Bay, Kowloon , Hong Kong 999077.

Molecules have limited mobility in the solid state because of the strong intermolecular interactions, and therefore, applications based on solid-state molecular motions are seldom explored. Herein, by manipulating the solid-state intramolecular motion of tetraphenylethylene (TPE) in a crystallizing polymer matrix, controlled fluorescent patterns with information storage and encoding functionality are developed. The intramolecular mobility of TPE can not only affect the fluorescence intensity but also determine the photocyclization activity, which can be tuned by surrounding polymer rigidity. The soft amorphous region in the semicrystalline polymer facilitates the intramolecular motion to achieve weak blue emission and high photocyclization activity, whereas the rigid crystalline phase restricts the intramolecular motion to give intense blue emission and low photoreactivity. Meanwhile, in the process of crystallization, the dynamic movement of the polymer chain in the crystal growth boundary layer further accelerates the intramolecular motions of TPE, allowing enhanced photoreactivity across crystalline and amorphous regions. The motion-dominated fluorescence allows TPE as a smart molecular robot to generate desired fluorescent patterns triggered by polymer crystallization. Our findings provide a correlation between microscopic molecular motions and macroscopic optical signals.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsnano.9b08761DOI Listing
February 2020

Polymorph selectivity of an AIE luminogen under nano-confinement to visualize polymer microstructures.

Chem Sci 2019 Nov 22;11(4):997-1005. Epub 2019 Nov 22.

Department of Chemistry, The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study and Development of Chemical and Biological Engineering, The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China

Despite the huge progress of luminescent molecular assemblies over the past decade, it is still challenging to understand their confined behavior in semi-crystalline polymers for constrained space recognition. Here, we report a polymorphic luminogen with aggregation-induced emission (AIE), capable of selective growth in polymer amorphous and crystalline phases with distinct color. The polymorphic behaviors of the AIE luminogen embedded within the polymer network are dependent on the size of nano-confinement: a thermodynamically stable polymorph of the AIE luminogen with green emission is stabilized in the amorphous phase, while a metastable polymorph with yellow emission is confined in the crystalline phase. The information on polymer crystalline and amorphous phases is transformed into distinct fluorescence colors, allowing a single AIE luminogen as a fluorescent marker for visualization of polymer microstructures in terms of amorphous and crystalline phase distribution, quantitative polymer crystallinity measurement, and spatial morphological arrangement. Our findings demonstrate that confinement of the AIE luminogen in the polymer network can achieve free space recognition and also provide a correlation between microscopic morphologies and macroscopic optical signals. We envision that our strategy will inspire the development of other materials with spatial confinement to incorporate AIE luminogens for various applications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9sc04239cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146380PMC
November 2019

Outcomes of 23G vitrectomy and internal limiting membrane peeling with brilliant blue in patients with myopic foveoschisis from a retrospective cohort study.

Exp Ther Med 2019 Jul 24;18(1):589-595. Epub 2019 May 24.

Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

The aim of the present study was to investigate whether internal limiting membrane (ILM) peeling in patients with myopic foveoschisis (MF) treated with 23-gauge (23G) vitrectomy improved the anatomical and visual outcomes. In this retrospective cohort study, from March 2014 to August 2017 at the Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University (Nanchang, China), 60 patients (60 eyes) with MF underwent 23G vitrectomy. The patients were grouped according to whether they underwent brilliant blue-assisted ILM peeling (peeling group) or not (non-peeling group). Best-corrected visual acuity (BCVA) and central macular thickness (CMT) on optical coherence tomography were measured. There were 30 eyes in each group and the baseline characteristics were similar (all P>0.05). BCVA improved in 24 eyes (80%) in the peeling group and 25 eyes (83.3%) in the non-peeling group (P=0.922). Preoperative CMT was not significantly different between the peeling and non-peeling group (458±62.2 vs. 460±61.1 µm, respectively, P=0.229). However, postoperative CMT was significantly different between the peeling and non-peeling group (269.3±67.7 vs. 294.4±60.5 µm, respectively; P=0.015). In the peeling group, MF was completely resolved in all 30 eyes, but only in 26 eyes in the non-peeling group (P=0.038). Postoperative Amsler testing was positive in five eyes in the peeling group and 13 eyes in the non-peeling group (P=0.024). Complications were similar in both groups; postoperatively, there were one and two cases of iatrogenic peripheral retinal break, three and two cases of macular hole, and one and one case of retinal detachment in the peeling and non-peeling groups, respectively.23G vitrectomy combined with brilliant blue-assisted ILM peeling resulted in better visual and anatomical effects compared with 23G vitrectomy alone in patients with MF.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3892/etm.2019.7610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566017PMC
July 2019

Spontaneous and Fast Molecular Motion at Room Temperature in the Solid State.

Angew Chem Int Ed Engl 2019 03 28;58(14):4536-4540. Epub 2019 Feb 28.

Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.

The development of molecular machines requires new building blocks which are easy to characterize and visualize to realize a complexity comparable to their natural counterparts such as biological enzymes. Furthermore, with the desire to build functional nanobots capable of navigating living organisms, it is necessary that the building blocks show mobility even in the solid state. Herein we report a system which is emissive in the amorphous state but is non-fluorescent in the crystalline state due to the formation of extensive π-π interactions. This dual nature could be exploited for easy visualization of its solid-state molecular rearrangement. The emission of the amorphous film was quenched as the molecules spontaneously formed π-π interactions even in the solid state. Scratching the non-emissive film destroyed the interactions and restored the emission of the film. The emission quickly disappeared with an average lifetime of 20 s as the compound reformed the π-network even at room temperature.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201813554DOI Listing
March 2019

Visualizing the Initial Step of Self-Assembly and the Phase Transition by Stereogenic Amphiphiles with Aggregation-Induced Emission.

ACS Nano 2019 Jan 20;13(1):839-846. Epub 2018 Dec 20.

HKUST-Shenzhen Research Institute , No. 9 Yuexing first RD, South Area, Hi-tech Park , Nanshan, Shenzhen 518057 , China.

Many highly ordered structures with smart functions are generated by self-assembly with stimuli responsiveness. Despite that electron microscopes enable us to directly observe the end products, it is hard to visualize the initial step and the kinetic stimuli-responsive behavior of self-assembly. Here, we report the design and synthesis of stereogenic amphiphiles, namely, ( Z)-TPE-OEG and ( E)-TPE-OEG, with aggregation-induced emission (AIE) characteristics from the hydrophobic tetraphenylethene core and thermoresponsive behavior from the hydrophilic oligoethylene glycol monomethyl ether chain. The two isomers can be easily isolated by high-performance liquid chromatography and characterized by 2D NMR spectroscopy. While ( Z)-TPE-OEG self-assembles into vesicles, its ( E)-cousin forms micelles in water. The initial step of their self-assembly processes can be visualized based on AIE characteristics, with a sensitivity much higher than the method based on transmittance measurement. The entrapment and release capabilities of the ( Z)-stereogenic amphiphile are demonstrated by employing pyrene as a guest. The thermoresponsive behavior of the ( Z)-amphiphile results in its continuous phase transition from microscopic self-assembly to macroscopic aggregation, which is successfully visualized in situ by confocal laser scanning microscopy accompanied by the AIE technique. Such a kinetic process shows different stages according to the microscopic visualization, and these stages have never been monitored through roughly observing the appearance of precipitates. It is anticipated that this study can deepen the understanding of the self-assembly processes for better monitoring and controlling them in different systems.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsnano.8b08358DOI Listing
January 2019

Apolipoprotein E favours the blunting by high-fat diet of prostacyclin receptor activation in the mouse aorta.

Br J Pharmacol 2018 09 22;175(17):3453-3469. Epub 2018 Jul 22.

Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, SAR, China.

Background And Purpose: NO-mediated, endothelium-dependent relaxations of isolated arteries are blunted by ageing and high-fat diets, as well as by apolipoprotein E deletion. The present study was designed to test the hypothesis that apolipoprotein E deletion impairs endothelium-dependent responses to prostacyclin (IP) receptor activation.

Experimental Approach: Five-week-old ApoE and ApoE mice were fed normal chow or high-fat diet for 29 weeks. The aortae were isolated for the measurements of isometric tension in Halpern-Mulvany myographs. Levels of proteins were assessed by Western blotting and immunofluorescence, and cyclic nucleotide levels by elisa.

Key Results: The IP receptor agonist, iloprost, induced endothelium-, NO-synthase- and IP-dependent relaxations in aortae of young ApoE mice. High-fat diet favoured activation of thromboxane receptors by iloprost, causing contraction. Apolipoprotein E was present in aortae of ApoE mice, especially in endothelium. Its presence was augmented by high-fat diet. Its deletion potentiated iloprost-induced relaxations in aortae of young mice and prevented the blunting of this response by high-fat diet. Levels of cAMP were higher, but those of cGMP were lower in the aorta of ApoE than in ApoE mice of the same age. The levels of IP receptor protein were not different between ApoE and ApoE mice.

Conclusions And Implications: Iloprost induced an endothelium-dependent relaxation in the aorta of young healthy mice which involved both the cGMP and cAMP pathways. This response was blunted by prolonged exposure to a high-fat diet. Apolipoprotein E deletion potentiated relaxations to IP receptor activation, independently of age and diet.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/bph.14386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086984PMC
September 2018

In Situ Monitoring of RAFT Polymerization by Tetraphenylethylene-Containing Agents with Aggregation-Induced Emission Characteristics.

Angew Chem Int Ed Engl 2018 05 23;57(21):6274-6278. Epub 2018 Apr 23.

Department of Chemistry, Hong Kong Branch of Chinese National, Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science and Division of Biomedical Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.

A facile and efficient approach is demonstrated to visualize the polymerization in situ. A group of tetraphenylethylene (TPE)-containing dithiocarbamates were synthesized and screened as agents for reversible addition fragmentation chain transfer (RAFT) polymerizations. The spatial-temporal control characteristics of photochemistry enabled the RAFT polymerizations to be ON and OFF on demand under alternating visible light irradiation. The emission of TPE is sensitive to the local viscosity change owing to its aggregation-induced emission characteristic. Quantitative information could be easily acquired by the naked eye without destroying the reaction system. Furthermore, the versatility of such a technique was well demonstrated by 12 different polymerization systems. The present approach thus demonstrated a powerful platform for understanding the controlled living radical polymerization process.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201803268DOI Listing
May 2018

TSPA as a novel ATF6α translocation inducer efficiently ameliorates insulin sensitivity restoration and glucose homeostasis in db/db mice.

Biochem Biophys Res Commun 2018 05 9;499(4):948-953. Epub 2018 Apr 9.

CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China.

Activating transcription factor 6α (ATF6α) as a transducer in unfolded protein response (UPR), plays an important role in liver glucose metabolism and insulin resistance. Thus, targeting ATF6α activation has been proposed to be a potential strategy for anti-T2DM drug discovery. Here, we determined that small molecule 2-[5-[1-(4-chlorophenoxy)ethyl]-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide (TSPA) functioned as an ATF6α translocation inducer effectively promoting ATF6α translocation into nucleus and ameliorating glucose homeostasis on db/db mice. TSPA promoted ATF6α translocation into nucleus without incresing C/EBP-homologous protein (CHOP) expression. TSPA restored the tunicamycin (TM)-stimulated insulin receptor (IR) desensitization through ATF6α activation, inhibited gluconeogenesis and efficiently improved glucose homeostasis on db/db mice. Furthermore, TSPA protected insulin pathway involving p38/X-box binding protein 1s (Xbp1s)/ER chaperones signaling pathway. Our current study has determined that ATF6α was a promising therapeutic target and also highlighted the potential of TSPA in the treatment of type 2 diabetes mellitus (T2DM).
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2018.04.025DOI Listing
May 2018

Precise optical modeling of quantum dots for white light-emitting diodes.

Sci Rep 2017 11 30;7(1):16663. Epub 2017 Nov 30.

School of Energy and Power Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.

Quantum dots (QDs)-based white light-emitting diodes (QDs-WLEDs) have been attracting numerous attentions in lighting and flat panel display applications, by virtue of their high luminous efficacy and excellent color rendering ability. However, QDs' key optical parameters including scattering, absorption and anisotropy coefficients for optical modeling are still unclear, which are severely against the design and optimization of QDs-WLEDs. In this work, we proposed a new precise optical modeling approach towards QDs. Optical properties of QDs-polymer film were obtained for the first time, by combining double integrating sphere (DIS) system measurement with inverse adding doubling (IAD) algorithm calculation. The measured results show that the typical scattering, absorption and anisotropy coefficients of red emissive QDs are 2.9382 mm, 3.7000 mm and 0.4918 for blue light, respectively, and 1.2490 mm, 0.6062 mm and 0.5038 for red light, respectively. A Monte-Carlo ray-tracing model was set-up for validation. With a maximum deviation of 1.16%, the simulated values quantitatively agree with the experimental results. Therefore, our approach provides an effective way for optical properties measurement and precise optical modeling of QDs for QDs-WLEDs.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-16966-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709500PMC
November 2017

Multiscale Humidity Visualization by Environmentally Sensitive Fluorescent Molecular Rotors.

Adv Mater 2017 Dec 16;29(46). Epub 2017 Oct 16.

Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute of Molecular Functional Materials, State Key Laboratory of Nanoscience, Division of Biomedical Engineering and Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.

Building humidity sensors possessing the features of diverse-configuration compatibility, and capability of measurement of spatial and temporal humidity gradients is of great interest for highly integrated electronics and wearable monitoring systems. Herein, a visual sensing approach based on fluorescent imaging is presented, by assembling aggregation-induced-emission (AIE)-active molecular rotors into a moisture-captured network; the resulting AIE humidity sensors are compatible with diverse applications, having tunable geometries and desirable architectures. The invisible information of relative humidity (RH) is transformed into different fluorescence colors that enable direct observation by the naked eyes based on the twisted intramolecular charge-transfer effect of the AIE-active molecular rotors. The resulting AIE humidity sensors show excellent performance in terms of good sensitivity, precise quantitative measurement, high spatial-temporal resolution, and fast response/recovery time. Their multiscale applications, such as regional environmental RH detection, internal humidity mapping, and sensitive human-body humidity sensing are demonstrated. The proposed humidity visualization strategy may provide a new insight to develop humidity sensors for various applications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/adma.201703900DOI Listing
December 2017

Optical modeling based on mean free path calculations for quantum dot phosphors applied to optoelectronic devices: comment.

Opt Express 2017 Oct;25(21):25098-25101

A recent publication by Shin et al. [Opt. Express25, A113 (2017)] contains an optical simulation model for the quantum dots (QDs) nanophosphor based on the mean free path concept. We show that their measured scattering pattern of QDs is misleading, which would result in a fatal deviation between simulated and actual values.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OE.25.025098DOI Listing
October 2017

Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation.

Eur J Med Chem 2017 Oct 25;139:128-152. Epub 2017 Jul 25.

Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, PR China. Electronic address:

Glucokinase (GK) activators are being developed for the treatment of type 2 diabetes mellitus (T2DM). However, existing GK activators have risks of hypoglycemia caused by over-activation of GK in islet cells and dyslipidemia caused by over-activation of intrahepatic GK. In the effort to mitigate risks of hypoglycemia and dyslipidemia while maintaining the promising efficacy of GK activator, we investigated a series of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific partial GK activators, which led to the identification of compound 72 that showed a good balance between in vitro potency and enzyme kinetic parameters, and protected β-cells from streptozotocin-induced apoptosis. Chronic treatment of compound 72 demonstrated its potent activity in regulation of glucose homeostasis and low risk of dyslipidemia with diabetic db/db mice in oral glucose tolerance test (OGTT). Moreover, acute treatment of compound 72 did not induce hypoglycemia in C57BL/6J mice even at 200 mg/kg via oral administration.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2017.07.051DOI Listing
October 2017

Realization of wide circadian variability by quantum dots-luminescent mesoporous silica-based white light-emitting diodes.

Nanotechnology 2017 Oct 28;28(42):425204. Epub 2017 Jul 28.

School of Energy and Power Engineering, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China. Department of Electrical & Electronic Engineering, Southern University of Science and Technology, Shenzhen, 518055, People's Republic of China.

Human comfort has become one of the most important criteria in modern lighting architecture. Here, we proposed a tuning strategy to enhance the non-image forming photobiological effect on the human circadian rhythm based on quantum-dots-converted white light-emitting diodes (QDs-WLEDs). We introduced the limiting variability of the circadian action factor (CAF), defined as the ratio of circadian efficiency and luminous efficiency of radiation. The CAF was deeply discussed and was found to be a function of constraining the color rendering index (CRI) and correlated color temperatures. The maximum CAF variability of QDs-WLEDs was found to be dependent on the QDs' peak wavelength and full width at half maximum. With the optimized parameters, the packaging materials were synthesized and WLEDs were packaged. Experimental results show that at CRI > 90, the maximum CAF variability can be tuned by 3.83 times (from 0.251 at 2700 K to 0.961 at 6500 K), which implies that our approach could reduce the number of tunable channels, and could achieve wider CAF variability.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6528/aa82d7DOI Listing
October 2017

Plasma D-dimer Can Effectively Predict the Prospective Occurrence of Ascites in Advanced Schistosomiasis Japonica Patients.

Korean J Parasitol 2017 Apr 30;55(2):167-174. Epub 2017 Apr 30.

Jiangxi Provincial Institute of Parasitic Diseases, Nanchang, P. R. China.

China still has more than 30,000 patients of advanced schistosomiasis while new cases being reported consistently. D-dimer is a fibrin degradation product. As ascites being the dominating symptom in advanced schistosomiasis, the present study aimed to explore a prediction model of ascites with D-dimer and other clinical easy-achievable indicators. A case-control study nested in a prospective cohort was conducted in schistosomiasis-endemic area of southern China. A total of 291 patients of advanced schistosomiasis were first investigated in 2013 and further followed in 2014. Information on clinical history, physical examination, and abdominal ultrasonography, including the symptom of ascites was repeatedly collected. Result showed 44 patients having ascites. Most of the patients' ascites were confined in the kidney area with median area of 20 mm. The level of plasma D-dimer and pertinent liver function indicators were measured at the initial investigation in 2013. Compared with those without ascites, cases with ascites had significantly higher levels of D-dimer (0.71±2.44 μg/L vs 0.48±2.12 μg/L, =0.005), as well ALB (44.5 vs 46.2, g/L) and Type IV collagen (50.04 vs 44.50 μg/L). Receiver operating characteristic curve analyses indicated a moderate predictive value of D-dimer by its own area under curve (AUC) of 0.64 (95% CI: 0.54-0.73) and the cutoff value as 0.81 μg/L. Dichotomized by the cutoff level, D-dimer along with other categorical variables generated a prediction model with AUC of 0.76 (95% CI: 0.68-0.89). Risks of patients with specific characteristics in the prediction model were summarized. Our study suggests that the plasma D-dimer level is a reliable predictor for incident ascites in advanced schistosomiasis japonica patients.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3347/kjp.2017.55.2.167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450959PMC
April 2017

Bonding-induced thermal transport enhancement across a hard/soft material interface using molecular monolayers.

Phys Chem Chem Phys 2017 Mar;19(10):7352-7358

State Key Laboratory of Coal Combustion, School of Energy and Power Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.

Manipulating thermal transport across hard/soft material interfaces is important for composites which are critical for a wide range of applications, including electronic packaging, thermal storage, sensors and medicine. To increase the interfacial thermal conductance (G), a previous strategy has focused on using a self-assembled monolayer (SAM) to bridge the phonon spectra mismatch between the materials constituting the interface. Here, we introduce a general strategy aiming for interfaces which are incompatible with the previous strategy. Copper (Cu) and epoxy resin are chosen as representative materials constituting the interface. The proposed strategy relies on using a strongly bonding SAM to covalently connect Cu and epoxy. The thermal measurements show that G can be enhanced by as much as 11 fold. An interesting result is found that the Cu/epoxy interface, modified with the SAM used in the previous strategy, shows approximate 2-fold lower G. Through a series of experiments, including tensile strength and wettability tests, the formation and characters of bonds in different interface systems are explored and understood. The correlation between bonding characters and G is also elucidated. We demonstrate that when the structure of the soft material is complex, interfacial thermal transport should be tuned by covalent bonds rather than by phonon spectra match. Finally, the great potential of the proposed strategy in manipulating the thermal properties of nanocomposites is illustrated here with a theoretical prediction.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/c7cp00209bDOI Listing
March 2017

Large Scale Production of Continuous Hydrogel Fibers with Anisotropic Swelling Behavior by Dynamic-Crosslinking-Spinning.

Macromol Rapid Commun 2016 Nov 14;37(22):1795-1801. Epub 2016 Oct 14.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai, 201620, P. R. China.

Hydrogel microfibers have been considered as a potential biomaterial to spatiotemporally biomimic 1D native tissues such as nerves and muscles which are always assembled hierarchically and have anisotropic response to external stimuli. To produce facile hydrogel microfibers in a mathematical manner, a novel dynamic-crosslinking-spinning (DCS) method is demonstrated for direct fabrication of size-controllable fibers from poly(ethylene glycol diacrylate) oligomer in large scale, without microfluidic template and in a biofriendly environment. The diameter of fibers can be precisely controlled by adjusting the spinning parameters. Anisotropic swelling property is also dependent on inhomogeneous structure generated in spinning process. Comparing with bulk hydrogels, the resulting fibers exhibit superior rapid water adsorption property, which can be attributed to the large surface area/volume ratio of fiber. This novel DCS method is one-step technology suitable for large-scale production of anisotropic hydrogel fibers which has a promising application in the area such as biomaterials.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/marc.201600430DOI Listing
November 2016

EUReKA! A Conceptual Model of Emotion Understanding.

Emot Rev 2016 Jul 22;8(3):258-268. Epub 2015 Apr 22.

North Carolina State University.

The field of emotion understanding is replete with measures, yet lacks an integrated conceptual organizing structure. To identify and organize skills associated with the recognition and knowledge of emotions, and to highlight the focus of emotion understanding as localized in the self, in specific others, and in generalized others, we introduce the conceptual framework of Emotion Understanding in Recognition and Knowledge Abilities (EUReKA). We then categorize fifty-six existing methods of emotion understanding within this framework to highlight current gaps and future opportunities in assessing emotion understanding across the lifespan. We hope the EUReKA model provides a systematic and integrated framework for conceptualizing and measuring emotion understanding for future research.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/1754073915580601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006746PMC
July 2016

NFKB1 common variants and PPP1R13L and CD3EAP in relation to lung cancer risk in a Chinese population.

Gene 2015 Aug 23;567(1):31-5. Epub 2015 Apr 23.

Key Laboratory of Environment and Population Health of Liaoning Education Ministry (Shenyang Medical College), Shenyang 110034, Liaoning Province, People's Republic of China.

Genetic variations in NFKB1 have been associated with cancer risk. This investigation intended to evaluate the possible association between common variants in NFKB1 and lung cancer risk and gene-gene and gene-environment interactions. A study containing 384 Chinese lung cancer cases and 387 cancer-free controls was conducted. 5 htSNPs (rs3774934, rs13117745, rs230541, rs1801, rs3774965) in NFKB1 and interaction with common variants in NFKB1 and PPP1R13L and CD3EAP and smoking-duration were assessed. No association with lung cancer risk was detected for individual htSNP in four genetic models, but the haplotype consisting of the wild-type alleles of rs3774934(G), rs13117745(C), rs230541(A), and rs1801(G) was associated with lowered lung cancer risk after adjustment for smoking duration [OR (95% CI) = 0.71 (0.51-0.98), P = 0.036]. There was no interaction between NFKB1 polymorphisms and PPP1R13L and CD3EAP and smoking status in relation to lung cancer risk. Two significant models: smoking duration as main effect (P < 0.0010) and smoking duration-PPP1R13L rs1970764 combination (P = 0.0040-0.0050) were tested. The results suggest that NFKB1 common variants and smoking duration and smoking duration-PPP1R13L rs1970764 interaction could be concerned with the lung cancer development in a Chinese population. The present findings add to the evidence implicating inflammation in lung cancer etiology.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gene.2015.04.059DOI Listing
August 2015

Aerosol-Assisted Heteroassembly of Oxide Nanocrystals and Carbon Nanotubes into 3D Mesoporous Composites for High-Rate Electrochemical Energy Storage.

Small 2015 Jul 16;11(26):3135-42. Epub 2015 Mar 16.

Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology, Department of Chemical Engineering, Tsinghua University, Beijing, 100084, P.R. China.

Nanostructured composites built from ordinary building units have attracted much attention because of their collective properties for critical applications. Herein, we have demonstrated the heteroassembly of carbon nanotubes and oxide nanocrystals using an aerosol spray method to prepare nanostructured mesoporous composites for electrochemical energy storage. The designed composite architectures show high conductivity and hierarchically structured mesopores, which achieve rapid electron and ion transport in electrodes. Therefore, as-synthesized carbon nanotube/TiO2 electrodes exhibit high rate performance through rapid Li(+) intercalation, making them suitable for ultrafast energy storage devices. Moreover, the synthesis process provides a broadly applicable method to achieve the heteroassembly of vast low-dimensional building blocks for many important applications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/smll.201403196DOI Listing
July 2015

In vitro and in vivo toxicity studies of copper sulfide nanoplates for potential photothermal applications.

Nanomedicine 2015 May 31;11(4):901-12. Epub 2015 Jan 31.

College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, People's Republic of China; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai, People's Republic of China. Electronic address:

Unlabelled: Copper sulfide (CuS) has emerged as a promising photothermal agent. However, its potential toxic effects still remained poorly understood. Herein, CuS nanoplates were synthesized for toxicity assessment. The in vitro study indicated that the cell viability decreased when CuS nanoplate concentration was higher than 100 μg/mL. CuS nanoplates caused apparent toxicity to HUVEC and RAW 264.7 cells. For acute toxicity, maximum tolerated dose and lethal dose 50 were 8.66 and 54.5 mg/kg, respectively. Furthermore, the sub-chronic toxicity test results indicated that there was no obvious effect at tested doses during the test period. The biodistribution study showed that intravenously administrated CuS nanoplates were mainly present in the spleen, liver and lung. Taken together, our results shed light on the rational design of CuS nanomaterials to minimize toxicity, thus providing a useful guideline in selecting CuS as the photothermal agent for cancer therapy.

From The Clinical Editor: Photothermal ablation therapy is a promising new treatment modality for cancer. One of the potential photothermal agents is copper sulfide (CuS). In this article, the potential toxic effects of CuS nanoplates were studied. The authors showed that further modification on the design of CuS nanomaterials was needed to minimize toxicity.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nano.2014.12.015DOI Listing
May 2015

A novel nanocomposite hydrogel with precisely tunable UCST and LCST.

Macromol Rapid Commun 2015 Mar 22;36(5):477-82. Epub 2015 Jan 22.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai, 201620, P.R. China.

Novel thermosensitive nanocomposite (NC) hydrogels consisting of organic/inorganic networks are prepared via in situ free radical polymerization of 2-(2-methoxyethoxy) ethyl methacrylate (MEO2 MA) and oligo(ethylene glycol) methacrylate (OEGMA) in the presence of inorganic cross-linker clay in aqueous solution. The obtained clay/P(MEO2 MA-co-OEGMA) hydrogels exhibit double volume phase transition temperatures, an upper critical solution temperature (UCST), and a lower critical solution temperature (LCST), which can be controlled between 5 and 85 °C by varying the fraction of OEGMA units and the weight percentage of cross-linker clay. These new types of NC hydrogels with excellent reversible thermosensitivity are promising for temperature-sensitive applications such as smart optical switches.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/marc.201400665DOI Listing
March 2015

Building robust carbon nanotube-interweaved-nanocrystal architecture for high-performance anode materials.

ACS Nano 2014 Sep 4;8(9):9265-73. Epub 2014 Sep 4.

Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology, Department of Chemical Engineering, Tsinghua University , Beijing 100084, People's Republic of China.

Rational design of electrode materials is essential but still a challenge for lithium-ion batteries. Herein, we report the design and fabrication of a class of nanocomposite architecture featured by hierarchically structured composite particles that are built from iron oxide nanocrystals and carbon nanotubes. An aerosol spray drying process was used to synthesize this architecture. Such nanoarchitecture enhanced the ion transport and conductivity that are required for high-power anodes. The large volume changes of the anodes during lithium insertion and extraction are accommodated by the particle's resilience and internal porosity. High reversible capacities, excellent rate capability, and stable performance are attained. The synthesis process is simple and broadly applicable, providing a general approach toward high-performance energy storage materials.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/nn5031302DOI Listing
September 2014

Age Differences in Reactions to Social Rejection: The Role of Cognitive Resources and Appraisals.

J Gerontol B Psychol Sci Soc Sci 2015 Nov 28;70(6):830-9. Epub 2014 May 28.

Department of Psychology, North Carolina State University, Raleigh.

Objectives: Social rejection is a negative social experience individuals of all ages may encounter in everyday life. It is unclear whether social rejection affects older adults more or less than younger adults. This study investigated age differences in reactions following a direct rejection and the moderating effects of cognitive resources and appraisals.

Method: Eighty-three younger (18-26 years) and 53 older (60-86 years) adults engaged in an online interview during which they were either accepted or rejected seemingly by another participant. We examined participants' self-reported mood before and after the interview as well as verbal self-complexity.

Results: Older adults reported greater increases in hurt feelings following rejection than younger adults. The age difference was further moderated by cognitive resources and appraisals. Among older rejected adults, those who were poorer in processing speed and those who appraised the rejection more negatively felt more hurt feelings. Older rejected adults were also rated lower in self-complexity than older accepted adults, whereas younger rejected adults and accepted adults did not differ.

Discussion: The findings are largely consistent with life-span developmental theories and highlight the importance of cognitive processes when examining age differences in experiencing social rejection.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/geronb/gbu054DOI Listing
November 2015

Polymer grafted hydroxyapatite whisker as a filler for dental composite resin with enhanced physical and mechanical properties.

Mater Sci Eng C Mater Biol Appl 2013 Dec 31;33(8):4994-5000. Epub 2013 Aug 31.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Material Science and Engineering, Donghua University, Shanghai 201620, PR China.

The objective of this study was to investigate the effect of surface graft polymerization of hydroxyapatite whisker (HW) on physical and mechanical properties of dental composite resin. Poly bisphenol A glycidyl methacrylate (Poly(Bis-GMA)) was grafted onto silanized hydroxyapatite whisker (SHW) via solution polymerization and the amount of the Poly(Bis-GMA) on the surface was effectively controlled by polymerization time. The obtained poly(Bis-GMA) grafted hydroxyapatite whisker (PGHW) with different polymer contents was filled into a resin matrix respectively, meanwhile the composites with HW and with SHW served as controls. Monomer conversion was characterized by Fourier transform infrared spectroscopy (FTIR) and volume shrinkage of the composite resin was measured with a density tester. Mechanical properties were tested with a universal testing machine. The results indicated that the composite filled with PGHW-1h (graft ratio of poly(Bis-GMA): 8.5 wt.%) showed lower shrinkage and better mechanical properties, improving flexural strength by 6.5% and 11.9% compared with SHW filled composite and HW filled composite, respectively. However, PGHW with higher graft ratios aggregated seriously and formed defects in the composite, leading to deterioration of mechanical properties. It was revealed that the poly(Bis-GMA) on the surface of PGHW acted as a functional transition layer and enhanced interfacial compatibility and interaction between whisker and resin matrix, which facilitated the dispersion of PGHW in the composite and decreased the composite shrinkage. Thus, the graft polymerization of Bis-GMA on the surface of filler might be a promising modification method for the fabrication of dental materials.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.msec.2013.08.029DOI Listing
December 2013
-->