Publications by authors named "Yanguo Liu"

44 Publications

Effects of long noncoding RNA on prognosis of oral squamous cell carcinoma: A protocol for systematic review and meta analysis.

Medicine (Baltimore) 2021 Apr;100(16):e25507

Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Shandong University, Jinan.

Background: Long noncoding RNA (lncRNA) is reported to be upregulated in many tumors. Although the expression of lncRNA in oral squamous cell carcinoma has been assessed, the association between lncRNA expression and prognosis or clinicopathological feature still remains controversial. Therefore, we conducted a meta-analysis to verify whether lncRNA expression was related to prognosis or clinicopathological features in patients with oral squamous cell carcinoma.

Methods: We searched Embase, PubMed, Web of Science, Cochrane library, Chinese National Knowledge Infrastructure, and Wanfang databases from inception to February 2021. The language included Chinese and English. The published literature on lncRNA expression and prognosis or clinicopathological characteristics of patients with oral squamous cell carcinoma was statistically analyzed. The combination of hazard ratios (HRs), odds ratios (OR), and 95% confidence intervals (95% CIs) were applied to evaluate the effects of lncRNA on the prognosis and clinicopathological features of oral squamous cell carcinoma.

Results: This study could provide a comprehensive review of the available evidence of lncRNA on the prognosis and clinicopathological features of oral squamous cell carcinoma.

Conclusion: The conclusion of our study will provide the updated evidence to judge the lncRNA on the prognosis and clinicopathological features of oral squamous cell carcinoma.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000025507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078265PMC
April 2021

Ni and Co synergy in bimetallic nanowires for the electrochemical detection of hydrogen peroxide.

Nanotechnology 2021 May;32(20):205501

Nanomaterials Research Group, Physics Division, PINSTECH, Islamabad 44000, Pakistan. Centre for High Energy Physics, University of the Punjab, Lahore 54590, Pakistan.

The development of a highly sensitive and selective non-enzymatic electrode catalyst for the detection of a target molecule was remained a great challenge. In this regard, bimetallic nanowires (BMNWs) are considered as promising electrode material for their fascinating physical/chemical properties superior to a single system. In this article, nickel cobalt (Ni -Co) BMNWs with tunable stoichiometry were prepared by a template assisted electrodeposition method and their catalytic performance was investigated for the detection of hydrogen peroxide (HO). It has been found that Ni-Co (0.5:1) BMNWs/PC electrode exhibits superior non-enzymatic sensing ability toward HO detection with a high selectivity. The electrode shows fast response within ∼3 s and an excellent reproducible sensitivity of 2211.4 μAmM cm, which is the best compared to the individual Ni, Co, Ni-Co (0.3:1) BMNWs and previously reported electrodes. In addition, the electrode shows a linear response in the wide concentration range from 0.005 mM to 9 mM, low detection limit of 0.5 μM (S/N = 3.2) and a relatively long-term storage (50 d). Moreover, the sensor reveals excellent results for HO detection in the real samples. The enhanced sensitivity of the Ni-Co (0.5:1) BMNWs based electrode may be due to the stable structure and synergy of Ni and Co. The results demonstrate that the catalytic activity of the electrode binary catalyst towards HO detection can be improved by adjusting the Ni/Co ratio in BMNWs. The excellent performance of the electrode suggests that Ni-Co BMNWs are promising candidate for the construction of cost-effective electrochemical sensors for medical and industrial applications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6528/abe4fbDOI Listing
May 2021

Right diaphragm metastasis of endometrial cancer: a case report.

J Int Med Res 2020 Oct;48(10):300060520961706

Department of Thoracic Surgery, Peking University People's Hospital, Beijing, P.R. China.

A diaphragmatic tumor is usually caused by metastasis from lung cancer, malignant mesothelioma, and malignant thymoma. Endometrial cancer is rarely involved in metastasis to the diaphragm. A right anterior mediastinal tumor was found in a 60-year-old woman who was initially diagnosed with endometrial carcinoma. There was initially no relationship between the right anterior mediastinal tumor and endometrial carcinoma. Radical curative surgery was performed for endometrial carcinoma. The endometrial carcinoma stage was IA. The patient was admitted to the Department of Thoracic Surgery 6 months after the curative surgery. Intraoperative exploration showed a tumor growing in the right diaphragm. Right diaphragmotomy was performed. Immunohistochemistry showed metastasis of endometrial carcinoma to the diaphragm. Endometrial cancer solitary metastasis to the diaphragm is rare. Clinicians should be aware of this possibility. Surgical treatment followed by a pathological examination is the most useful method for determining the diagnosis of a diaphragmatic tumor due to metastasis of endometrial cancer.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/0300060520961706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556180PMC
October 2020

Pulmonary Involvement in Birt-Hogg-Dubé Syndrome.

Chest 2020 Oct;158(4):1791-1793

Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing, China. Electronic address:

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chest.2020.03.086DOI Listing
October 2020

M2 macrophages reduce the effect of gefitinib by activating AKT/mTOR in gefitinib-resistant cell lines HCC827/GR.

Thorac Cancer 2020 11 21;11(11):3289-3298. Epub 2020 Sep 21.

Department of Medical Oncology, Qilu Hospital of Shandong University, Jinan, China.

Background: The biological behavior of cells change after they develop drug resistance, and the degree of resistance will be affected by the tumor microenvironment. Here, we aimed to explore the changes in the biological behavior of tumors and to observe the differences in the release of cytokines and chemokines which can influence the tumor microenvironment. We also aimed to study how TKIs-resistant cell lines recruit macrophages to reduce the sensitivity of the cells following gefitinib administration.

Methods: We generated and maintained gefitinib-resistant cell lines to study the differences between gefitinib-sensitive cell lines according to clone formation, cell growth curve analysis, whole-exome sequencing, and qPCR ARRAY technology. We used the WNT/β-catenin inhibitor, WNT/β-catenin activator and overexpression β-catenin lentivirus to observe the changes in CCL2. M2 macrophages and gefitinib-resistant cell lines HCC827/GR were cocultured to detect the viability gefitinib for inducing cell death.

Results: The proliferation and migratory activities were much more pronounced in HCC827/GR cells. CCL2 expression was also enhanced and regulated by β-catenin in HCC827/GR. CCL2 promoted the chemotactic ability of M2 macrophages. M2 macrophages reduced the antitumor effect of gefitinib treatment by activating AKT/mTOR.

Conclusions: Gefitinib-resistant cell lines have stronger proliferation and migration capabilities, and attract macrophages by releasing more CCL2 to reduce the sensitivity of cells to gefitinib.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1759-7714.13670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606002PMC
November 2020

BiSb@BiO/SbO encapsulated in porous carbon as anode materials for sodium/potassium-ion batteries with a high pseudocapacitive contribution.

J Colloid Interface Sci 2020 Nov 15;580:429-438. Epub 2020 Jul 15.

School of Materials Science and Engineering, Northeastern University, Shenyang 110819, China; School of Resources and Materials, Northeastern University at Qinhuangdao, Qinhuangdao 066004, China; Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province, Qinhuangdao, China.

Sodium-ion batteries (SIBs) and potassium-ion batteries (PIBs) are emerging next-generation energy storage technology, and exploiting applicative electrode materials to accommodate the large-sized Na and K are urgently needed. Herein, an innovative composite of BiSb@BiO/SbO nanoparticles encapsulated in porous carbon (BiSb@BiO/SbO@C) is fabricated through a template-assisted in-situ pyrogenic decomposition and evaluated as anodes for SIBs and PIBs. The BiSb@BiO/SbO@C delivers high specific capacity, superior rate capability (205 mA h g and 111 mA h g at 2 Ah g) and good cycling stability (248 mA h g and 214 mA h g after 500 cycles at 1 A g) in SIBs and PIBs. The excellent performance owes to the synergistic effect of Bi and Sb, the multilayer nanostructure design as well as the interconnected porous carbon network, which effectively promotes electron transport and ion diffusion, restricts volume change and enhances the electrode structure stability simultaneously. Furthermore, the capacitive behavior contributes much to the storage of sodium and potassium ions, which guarantees a superior rate capability. This research opens up new opportunities for exploring high-performance anodes for SIBs and PIBs.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcis.2020.07.061DOI Listing
November 2020

Tobacco extracts promote PD-L1 expression and enhance malignant biological differences via mTOR in gefitinib-resistant cell lines.

Thorac Cancer 2020 08 18;11(8):2237-2251. Epub 2020 Jun 18.

Department of Medical Oncology, Qilu Hospital, Shandong University, Jinan, Shandong, China.

Background: The aim of this study was to investigate whether tobacco extracts could regulate PD-L1 expression and enhance malignant biological differences in gefitinib-resistant cell lines.

Methods: We constructed gefitinib-resistant cells and observed the biological differences in gefitinib-resistant cells. The cells were stimulated with medium containing 5% volume of tobacco extract, and the change in PD-L1 expression and the mammalian target of rapamycin (mTOR) and p-mTOR expression in gefitinib-resistant cells treated with tobacco extracts was observed. We discussed the relationship between PD-L1 and mTOR.

Results: Tobacco extracts could promote PD-L1 expression in the cell line. Western blot analysis showed that mTOR and p-mTOR were significantly enhanced in gefitinib-resistant cell lines cultured in the tobacco extracts. The mTOR signaling pathway was involved in PD-L1 expression and in regulating the expression of cytokines IL-6 and IL-23. In addition, the tobacco extracts could promote macrophage migration via mTOR/IL-6.

Conclusions: PD-L1 can transmit inhibitory signals and reduce the proliferation of CD8 + T cells in lymph nodes. Tobacco extracts upregulate PD-L1 expression via mTOR/IL-6. These results imply that lung cancer patients should not smoke and stay away from a smoke environment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1759-7714.13533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396363PMC
August 2020

Systemic Inflammatory Response Markers Associated with Infertility and Endometrioma or Uterine Leiomyoma in Endometriosis.

Ther Clin Risk Manag 2020 11;16:403-412. Epub 2020 May 11.

Institute of Basic Medical Sciences, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan, Shandong 250012, People's Republic China.

Purpose: The aim of this study was to find the most useful marker of endometriosis-related infertility and evaluate predictive and diagnostic values of systemic inflammatory response markers (preoperative white blood-cell subtypes, neutrophil:lymphocyte ratio [NLR], platelet:lymphocyte ratio [PLR], and monocyte:lymphocyte ratio [MLR]) and CA125 levels in endometriosis patients.

Methods: This study comprised 662 women who had undergone laparoscopic surgery and been pathologically confirmed as having endometriosis and 83 patients pathologically confirmed with benign ovarian tumors. Related inflammatory factors in endometriosis complicated by infertility were analyzed via logistic regression analysis. Diagnostic values of the inflammatory response markers were obtained by receiver operating-characteristic analysis.

Results: We firstly identified that lower NLR level was an independent risk factor of infertility. Serum lymphocytes were significantly higher in endometriosis patients, while serum CA125, NLR, MLR, and PLR were elevated. For differentiating endometriosis from other benign ovarian tumors, the combination of NLR and CA125 achieved greater sensitivity than CA125 alone. In addition, both CA125 and NLR were positively correlated with stage, oviduct adhesion, and diameter of ovarian ectopic cysts.

Conclusion: NLR may be used as a simple and easily obtained predictive marker for endometriosis with infertility. Moreover, NLR can be a neoadjuvant biomarker for serum CA125 to diagnose endometriosis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2147/TCRM.S232849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229864PMC
May 2020

Ultrafast and Stable Lithium Storage Enabled by the Electric Field Effect in Layer-Structured Tablet-Like NHTiOF Mesocrystals.

ACS Appl Mater Interfaces 2020 May 21;12(18):20404-20413. Epub 2020 Apr 21.

School of Resources and Materials, Northeastern University at Qinhuangdao, Qinhuangdao 066004, PR China.

Design and synthesis of advanced electrode materials with fast and stable ion storage are of importance for energy storage applications. Herein, we propose that introducing the heterogeneous interface in layer-structured mesocrystals is an efficient way to greatly improve the rate capability and cycle stability of lithium-ion battery (LIB) devices. NHTiOF mesocrystals were employed as a typical model system to demonstrate the idea. The NHTiOF mesocrystals were obtained via the hydrothermal reaction, and the NHTiOF/TiO interfaces were generated through calcining at different temperatures under an argon atmosphere. Phase composition, microstructure, and chemical analyses show that the as-prepared NHTiOF mesocrystals possess "tablet-like" morphology, and the formation of the NHTiOF/TiO interface can be controlled by the calcination temperature. When evaluated as the anode for LIBs, the optimized sample (NHTiOF calcined at 250 °C, NTF-250) shows excellent, fast, and stable lithium storage properties. Specifically, the NTF-250 electrode holds a reversible capacity of 159.5 mA h g after 200 cycles at 0.2 A g. At a high current density of 20 A g, the electrode still maintains a reversible capacity of 89.6 mA h g and reaches a reversible capacity of 128.6 mA h g at a current density of 1 A g after 2000 cycles. Theoretical and experimental studies show that the synergistic effects of the heterogeneous NHTiOF/anatase TiO interface in the layer-structured NHTiOF mesocrystals lead to the upgraded electrochemical properties. Especially, the local build-in electric field induced by the nonuniform distribution of charge across the NHTiOF/anatase TiO interface facilitates the charge transport during the charging and discharging cycling. The current electrode design strategy paves a new way in boosting stable ion storage and thus is of great interest in energy storage and conversion.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.0c01795DOI Listing
May 2020

The safety and feasibility of intraoperative near-infrared fluorescence imaging with indocyanine green in thoracoscopic sympathectomy for primary palmar hyperhidrosis.

Thorac Cancer 2020 04 15;11(4):943-949. Epub 2020 Feb 15.

Department of Thoracic Surgery, Beijing Haidian Hospital (Haidian Section of Peking University Third Hospital), Beijing, China.

Background: We investigated the safety and feasibility of intraoperative near-infrared (NIR) imaging using indocyanine green (ICG) during sympathectomy in the management of primary palmar hyperhidrosis (PPH).

Methods: We performed a retrospective review of 142 patients (ICG group) who underwent endoscopic thoracic sympathectomy (ETS) between February 2018 and April 2019. All patients received a 5 mg/kg infusion of ICG 24 hours preoperatively. The vital signs before and after ICG injection and adverse reactions were recorded. Meanwhile, 498 patients (Non-ICG group) who underwent ETS by normal thoracoscopy during August 2017 to April 2019 were also reviewed to compare the abnormal white blood cell (WBC) counts, alanine transaminase (ALT), aspartate transaminase (AST), blood urea nitrogen (BUN), and creatinine (Cr) levels before and after operation between two groups.

Results: For ICG group, the vital signs including body temperature, heart rate and blood pressure before and after ICG injection were stable. There was no significant difference in the abnormal WBC counts, ALT, AST, BUN, and Cr levels before and after operation between two groups. Only one patient had mild adverse reaction (0.7%) after ICG injection. The visibility rate of all sympathetic ganglions was 96.7% (1369/1415). The visibility rate from T1 to T5 was 98.23% (278/283), 98.23% (278/283), 97.17% (275/283), 95.76% (271/283), and 94.35% (267/283), respectively. There was no significant difference in the visibility rate with regard to age, gender, height, weight, body mass index, and PPH grade.

Conclusions: NIR fluorescence imaging with ICG for identifying sympathetic ganglions is relatively safe and feasible.

Key Points: • Significant findings of the study. NIR fluorescence imaging with ICG for identifying sympathetic ganglions is relatively safe and feasible. • What this study adds. This technology may take the place of the rib-oriented method as standard practice for the precise localization of sympathetic ganglions, and may improve the effect of sympathectomies.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1759-7714.13345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113049PMC
April 2020

Endoscopic thoracic sympathicotomy for primary palmar hyperhidrosis: A retrospective multicenter study in China.

Surgery 2019 12 2;166(6):1092-1098. Epub 2019 Aug 2.

Department of Thoracic Surgery, First Affiliated Hospital of Fujian Medical University, Fuzhou, People's Republic of China. Electronic address:

Background: This study aimed to evaluate the clinical efficacy and safety of endoscopic thoracic sympathicotomy and to explore strategies to decrease the incidence of transfer hyperhidrosis (TH).

Methods: From January 2003 to July 2016, 10,275 patients with primary palmar hyperhidrosis underwent endoscopic thoracic sympathicotomy in 15 different institutions. We carried out a retrospective analysis of these patients who were grouped into group A, those with nonretained R2 (R2, R2-3, or R2-4 ablation), and group B, those with retained R2 (single R3 or R4 ablation).

Results: All procedures were performed successfully. Both hands of all patients became warm and dry immediately after endoscopic thoracic sympathicotomy. Pneumothorax occurred in 146 patients, and 39 patients had intraoperative bleeding. Follow-up was carried out from 6 months to 13 years. A total of 531 patients (5.2%) were lost to follow-up. The effective rate for primary palmar hyperhidrosis was 100%. Palmar hyperhidrosis recurred in 73 patients (0.7%). Transfer hyperhidrosis appeared in 7,678 patients (78.8%). For groups A and B, the incidence of TH was 80.4% and 78.5%, respectively (P > .05), but the incidence of grade III+IV TH in group B (1.6%) was less than that in group A (4.8%; P < .001).

Conclusion: Endoscopic thoracic sympathicotomy is a minimally invasive, safe, and effective therapeutic method for primary palmar hyperhidrosis. Although the overall incidence of TH is high, the incidence of grade III to IV TH can be decreased by reserving R2, lowering the level of thoracic sympathicotomy, and single severing of R3 or R4.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.surg.2019.05.039DOI Listing
December 2019

Familial spontaneous pneumothorax: importance of screening for Birt-Hogg-Dubé syndrome.

Eur J Cardiothorac Surg 2020 01;57(1):39-45

Department of Thoracic Surgery, Peking University People's Hospital, Beijing, China.

Objectives: The goal of this study was to investigate the prevalence of Birt-Hogg-Dubé (BHD) syndrome in patients with familial spontaneous pneumothorax (FSP) and the clinical characteristics of pneumothorax related to BHD syndrome compared with those of primary spontaneous pneumothorax.

Methods: A total of 37 families diagnosed with FSP from 2007 to 2017 were enrolled in this study. The FLCN gene, which is responsible for BHD syndrome, was sequenced using the Sanger method in 25 probands. For the patients with confirmed BHD syndrome-related pneumothorax, clinical characteristics including the median onset age of pneumothorax, the male-to-female ratio, the mean height and body mass index (BMI) and the recurrence rate after different treatment modalities were obtained and compared with those of patients with primary spontaneous pneumothorax.

Results: Of the 25 probands with FSP, 16 [64.0%, 95% confidence interval (CI) 43.8-84.2%] harboured FLCN germline mutations. In the patients with BHD syndrome-related pneumothorax, the median onset age of pneumothorax was 34 years; the male-to-female ratio was 1.3:1; and the mean height and BMI were 167.0 ± 8.6 cm and 23.6 ± 3.4 kg/m2, respectively. These characteristics were significantly different from those in patients with primary spontaneous pneumothorax from the same centre. The recurrence rate of BHD syndrome-related pneumothorax after conservative therapy was 53.1% (95% CI 38.6-67.5%) compared with 9.1% (95% CI 0-19.4%) after surgical treatment.

Conclusions: BHD syndrome is one of the most common causes of FSP. Patients with FSP should be recommended for mutation screening for the FLCN gene to facilitate early diagnosis and proper intervention.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/ejcts/ezz171DOI Listing
January 2020

Comparison of the Effectiveness of Surgical Versus Nonsurgical Treatment for Multiple Rib Fractures Accompanied with Pulmonary Contusion.

Ann Thorac Cardiovasc Surg 2019 Aug 8;25(4):185-191. Epub 2019 May 8.

Department of Thoracic and Cardiovascular Surgery, Yiyuan People's Hospital, Zibo, China.

Objective: To compare the effectiveness of surgical versus nonsurgical treatment for multiple rib fractures accompanied with pulmonary contusion.

Methods: The clinical records of consecutive 167 patients with multiple rib fractures accompanied with pulmonary contusion, who were treated from June 2014 to June 2017, were retrospectively analyzed. Of them, 75 and 92 underwent surgery (surgery group) and non-surgical treatment (non-surgery group), respectively. Patient pain score, complications, length of hospital stay, cost of hospitalization, and post-treatment 3-month follow-up results were compared.

Results: The mean number of days and moderate pain in the surgery group was significantly lower than that of the non-surgery group (p <0.01). The incidence of post-treatment complications was significantly lower in the surgery group than in the non-surgery group. The length of hospital stay of the surgery group was also significantly shorter than that of the non-surgery group (p <0.01). The cost of hospitalization was significantly higher in the surgery group than in the non-surgery group (p <0.01). The chest computed tomography (CT) scan which was performed 3 months after the treatment revealed that the surgery group had a better recovery than the non-surgery group. Physical recovery of the surgery group was also significantly better than that of the non-surgery group.

Conclusion: Surgery to treat multiple rib fractures (≥ 4 fractures) accompanied with pulmonary contusion is safe and effective.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5761/atcs.oa.18-00295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698715PMC
August 2019

Combined inhibition of sonic Hedgehog signaling and histone deacetylase is an effective treatment for liver cancer.

Oncol Rep 2019 Mar 23;41(3):1991-1997. Epub 2019 Jan 23.

Department of Histology and Embryology, Binzhou Medical University, Yantai, Shandong 264003, P.R. China.

Clinical trials have revealed that inhibition of sonic Hedgehog (SHH) signaling or histone deacetylase (HDAC) holds promise as a treatment for liver cancer. Based on our previous results, it was hypothesized that dual inhibition of SHH and HDAC may contribute to more efficient targeting of this disease. The effect of SHH inhibitor vismodegib as a single‑agent or in combination with HDAC inhibitor entinostat was evaluated by Cell Counting Kit‑8 (CCK‑8) and flow cytometric assays, as well as immunoblotting. The synergistic effect on cell viability was assessed by combination indexes. Ex vivo cultured liver cancer tissues from a patient were treated with vismodegib as a single‑agent or in combination with entinostat, and analyzed by histological and immunohistochemical methods. The results revealed that the dual use of the SHH inhibitor and the HDAC inhibitor effectively synergized to inhibit proliferation, and promote apoptosis in liver cancer cells. Furthermore, the effect of the combination of these drugs was confirmed in an ex vivo culture of human liver cancer tissue. Mechanistically, combined use of SHH and HDAC inhibitors resulted in significantly greater downregulation of SHH and PI3K/mTOR signaling. In conclusion, the combined use of SHH signaling and HDAC inhibitors may be an effective therapeutic strategy for liver cancer.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3892/or.2019.6982DOI Listing
March 2019

Preoperative neutrophil lymphocyte ratio but not platelet lymphocyte ratio predicts survival and early relapse in patients with oral, pharyngeal, and lip cancer.

Head Neck 2019 05 11;41(5):1468-1474. Epub 2019 Jan 11.

Institute of Basic Medical Sciences, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Background: To evaluate the prognostic value of preoperative neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) in oral, pharyngeal, and lip cancer for survival and relapse.

Methods: Clinic-pathologic and hematological records were retrospectively retrieved. Patients completed follow-up period were included for survival and relapse analysis.

Results: The preoperative NLR value was a prognostic factor for both overall survival and relapse-free survival. The high NLR group demonstrated higher total relapse rate, higher local relapse rate, and higher relapse rate within 12 months. However, the preoperative PLR did not associate with survival or relapse.

Conclusions: The preoperative NLR, not PLR, is an independent prognostic indicator of survival. It also exhibits predictive value for relapse, particularly early relapse within 12 months. The preoperative NLR value might be recommended as a useful tool for predicting the outcomes and stratifying patients for different management strategies.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/hed.25580DOI Listing
May 2019

Downregulation of basic fibroblast growth factor increases cisplatin sensitivity in A549 non-small cell lung cancer cells.

J Cancer Res Ther 2018 ;14(7):1519-1524

Department of Medical Oncology, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Objectives: The objective of the study is to investigate the role of basic fibroblast growth factor (bFGF) in sensitivity to cisplatin in non-small cell lung cancer (NSCLC) A549 cells and its effect on the stemness characteristics of NSCLC cells, revealing possible mechanisms of cisplatin resistance.

Materials And Methods: After A549 cells were treated with cisplatin, bFGF protein expression was analyzed by Western blot. A549 cells were transfected with bFGF small interfering RNAs (siRNAs), and the knockdown efficiency was confirmed by quantitative reverse transcription polymerase chain reaction and Western blot. After bFGF downregulation, A549 cell proliferation was assessed by Cell Counting Kit-8 assay. The effect of bFGF siRNA on the sensitivity to cisplatin was evaluated by cell viability assays and flow cytometry for cell apoptosis. Colony formation assay was performed to explore whether bFGF affected the stemness characteristics of A549 cells, and OCT-4 protein expression was analyzed by Western blot after bFGF siRNA treatment.

Results: Cisplatin treatment enhanced bFGF expression in A549 cells. After A549 cells were transfected with bFGF siRNAs, bFGF expression was significantly decreased compared to that in the negative control siRNA group. In addition, bFGF knockdown inhibited A549 cell proliferation. bFGF siRNA treatment enhanced the inhibitory effect of different concentrations of cisplatin on cell viability and promoted cisplatin-induced apoptosis in A549 cells. Further analyses showed that bFGF siRNA treatment not only significantly decreased colony formation in A549 cells but also downregulated OCT-4 protein expression.

Conclusion: bFGF decreased NSCLC sensitivity to cisplatin in vitro, while it enhanced colony formation ability and increased OCT-4 expression of A549 cells, which might account for its involved mechanisms of cisplatin resistance.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4103/jcrt.JCRT_481_18DOI Listing
February 2019

A long-term evaluation of postoperative moist hands after R4/R4+5 sympathectomy for primary palmar hyperhidrosis.

J Thorac Dis 2018 Mar;10(3):1532-1537

Department of Thoracic Surgery, Peking University People's Hospital, Beijing 100044, China.

Background: Thoracoscopic R4 sympathectomy has been recommended as a safe and effective surgical treatment procedure for primary palmar hyperhidrosis (PPH). However, approximately half of patients presented postoperative moist hands (PMH), and recurrence occurred individually. Therefore, more thorough long-term results should be evaluated.

Methods: Between January 2005 and December 2014, 506 consecutive patients with palmar hyperhidrosis treated with either R4 or R4+5 were retrospectively reviewed and followed-up.

Results: A total of 451 patients (89.1%) completed the follow-up with an average follow-up time of 30.7±25.4 months. Palmar sweating completely ceased in 178 patients (39.5%), whereas 215 (47.7%) achieved greater than 50% improvement, 43 (9.5%) achieved 20-50% improvement. Fifteen individuals (3.3%) experienced recurrence. The frequency of individuals achieving 100% improvement was significantly higher in the group R4+5 than in the group R4 (60.9% 27.8%, respectively; P<0.001). A total of 321 patients (71.2%) showed compensatory hyperhidrosis with 290 (64.3%) and 29 (6.4%) experiencing mild or moderate types respectively. Two individuals (0.4%) suffered from severe type. The incidence of compensatory hyperhidrosis in the group R4+5 was significantly lower than the group R4 (63.8% 73.7%, respectively; P=0.037). Regarding satisfaction, 345 (76.5%) and 83 (18.4%) patients were highly satisfied and partially satisfied with their surgical results, respectively. Six patients (1.3%) were dissatisfied, and 17 (3.8%) expressed regret for surgery.

Conclusions: PMH occurred in over half of patients after R4 or R4+5 sympathectomy, but most of these patients were satisfied with the surgical results. R4+5 appears to be a better option for palmar hyperhidrosis with lower incidence of PMH and compensatory hyperhidrosis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.21037/jtd.2018.02.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906351PMC
March 2018

After neoadjuvant chemotherapy platelet/lymphocyte ratios negatively correlate with prognosis in gastric cancer patients.

J Clin Lab Anal 2018 Jun 18;32(5):e22364. Epub 2017 Dec 18.

Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Introduction: Circulating predictors prognostic factors of neoadjuvant chemotherapy, which identify the patients who are potential possibly to benefit from it are limited at present. In this research, we aimed to compare the prognostic significance of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in patients with locally advance gastric carcinoma who were treated with neoadjuvant chemotherapy (NAC) followed by D2 gastrectomy.

Materials And Methods: From 2007 to 2015, 91 patients with locally advanced gastric cancer treated with NAC followed by D2 gastrectomy included in this retrospective cohort study. The correlation of clinical data, including tumor regression, response evaluation, tumor location, pathological type, systemic therapy, tumor size (cm), neural invasion, lymphatic-vascular invasion, ypTNM stage, and survival prognosis were analyzed.

Results: Platelet/lymphocyte ratio and neutrophil/lymphocyte ratio in gastric cancer patients were higher than in matched normal volunteers. PLR levels higher after neoadjuvant chemotherapy are associated with worse OS. Multivariate Cox proportional analysis showed that pre-neoadjuvant chemotherapy PLR was an independent prognostic factor.

Conclusions: Pre-neoadjuvant chemotherapy PLR may be a feasible biomarker for survival prognosis in patients with locally advanced gastric cancer. PLR and NLR were reduced after neoadjuvant chemotherapy. After neoadjuvant chemotherapy, PLR level was negatively correlated with survival prognosis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcla.22364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816988PMC
June 2018

The Roles of Glycodelin in Cancer Development and Progression.

Front Immunol 2017 29;8:1685. Epub 2017 Nov 29.

Qilu Hospital of Shandong University, Jinan, Shandong, China.

Glycodelin is a kind of glycoprotein expressed in secretory endometrium, pregnancy deciduas, and amniotic fluid originally, which is vital for the maintenance of normal human reproductive activities. Recent researches have reported that glycodelin is specifically expressed in various malignancies, including female-specific cancers such as endometrial cancer, ovarian cancer and breast cancer, and non-gender specific cancers including lung cancer, and colon cancer, and glycodelin expression correlates with the diagnosis and prognosis of cancer patients. This review focuses on the expression of glycodelin in different cancers and its role in cancer development and progression. Glycodelin possesses the abilities to regulate cancer cell proliferation, differentiation, and invasion, promote cancer angiogenesis, and modulate the differentiation and function of immune cells including T cells, dendritic cells, monocyte-macrophages, natural killer cells and B cells participating in cancer development. The expression of glycodelin can be regulated by stromal cells, lysophosphatidic acid, histone deacetylase inhibitors, and relaxin. In summary, glycodelin is a promising biomarker for the diagnosis and prognosis of cancer patients, and depending on its distinct immunoregulatory effects, glycodelin can be a prospective target for cancer immunotherapy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2017.01685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712544PMC
November 2017

PU.1-deficient mice are resistant to thioacetamide-induced hepatic fibrosis: PU.1 finely regulates Sirt1 expression via transcriptional promotion of and in hepatic stellate cells.

Biosci Rep 2017 Dec 12;37(6). Epub 2017 Dec 12.

Department of Hepatobiliary Surgery, Yantaishan Hospital, Yantai, China.

PU box binding protein (PU.1) is a critical transcription factor involved in many pathological processes. However, its exact role in activation of hepatic stellate cells (HSCs) and liver fibrosis was rarely reported. Here, we found that, in HSCs of PU.1 mice, mRNA expression was not changed but Sirt1 protein was significantly increased, suggesting its promoting role in Sirt1 translation. We then isolated HSCs from wild-type (WT) and PU.1 mice, and the pcDNA-PU.1 expression vector was transfected into PU.1 HSCs. We checked the levels of and , two Sirt1-targetting miRNAs, and protein levels of PU.1 and Sirt1. The results showed that were significantly reduced and Sirt1 protein was increased in PU.1 HSCs, compared with WT HSCs. Besides, PU.1 overexpression inversed the reduction in levels and the increase in Sirt1 protein in both PU.1 HSCs and WT HSCs. Additionally, ChIP-quantitive real-time PCR (qPCR) assay comfirmed that PU.1 was directly bound to both the promoter regions of and Importantly, PU.1 overexpression promoted the proliferation, migration, activation, oxidative stress and inflammatory response in WT HSCs, while the promotion could be inversed by either overexpression of Sirt1 or inhibition of Moreover, animal model of liver fibrosis was established by intraperitoneal injections of thioacetamide (TAA) in WT and PU.1 mice, respectively. Compared with the WT mice, PU.1 mice displayed a lower fibrotic score, less collagen content, better liver function, and lower levels of oxidative stress and inflammatory response. In conclusion, PU.1 suppresses Sirt1 translation via transcriptional promotion of , thus promoting Sirt1-mediated HSC activation and TAA-induced hepatic fibrosis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1042/BSR20170926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725609PMC
December 2017

Clinical and genetic study of a large Chinese family presented with familial spontaneous pneumothorax.

J Thorac Dis 2017 Jul;9(7):1967-1972

Department of Thoracic Surgery, Peking University People's Hospital, Beijing 100044, China.

Background: Familial spontaneous pneumothorax (FSP) is an inherited disease, and Birt-Hogg-Dubé (BHD) syndrome is its leading cause. BHD syndrome is an autosomal dominant disorder characterized by pulmonary cysts, spontaneous pneumothorax, renal cancer, and skin fibrofolliculomas. It is caused by germline mutations in the gene. Thus far a variety of mutations have been reported; however, the unique characteristics of BHD syndrome-related FSP are still unclear.

Method: We reviewed the family history of a large Chinese family that presented with FSP. Genetic testing of the gene was performed and the special clinical characteristics of BHD syndrome-related FSP were discussed.

Results: This family comprised 5 generations and 76 members. Six of these had experienced pneumothorax episodes and 35 members had undergone genetic analysis of the gene, except for one member who had pneumothorax. Among the 35 members, 17 had the mutation in the gene. All five members with pneumothorax had the mutation. Frequency of pneumothorax in the mutation members was 29.4% (5/17). Clinical characteristics of the BHD syndrome-related pneumothorax differed from those of primary spontaneous pneumothorax, which typically affects tall, thin young men, and the recurrence rate of BHD syndrome-related pneumothorax after observation, needle aspiration or tube drainage was higher than that of primary spontaneous pneumothorax, and higher than that observed after VATS bullectomy and mechanical pleurodesis.

Conclusions: We reported the largest single family that presented with FSP from China. The clinical and genetic characteristics of the BHD syndrome-related pneumothorax differ from those of primary spontaneous pneumothorax.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.21037/jtd.2017.06.69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542951PMC
July 2017

Reply.

Ann Thorac Surg 2017 05;103(5):1680

Department of Thoracic Surgery, Peking University People's Hospital, No. 11 Xizhimen S St, Xicheng District, Beijing, China.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.athoracsur.2016.09.068DOI Listing
May 2017

Fucoidan inhibits CCL22 production through NF-κB pathway in M2 macrophages: a potential therapeutic strategy for cancer.

Sci Rep 2016 10 24;6:35855. Epub 2016 Oct 24.

Institute of Basic Medical Sciences, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, P. R. China.

In tumor microenvironment, macrophages as a polarized M2 population promote tumor progression via releasing multiple cytokines and chemokines. A brown seaweed fucose-rich polysaccharide, fucoidan has antitumor activity and immune modulation through affecting tumor cells and lymphocytes. Here, we focused on the effect of fucoidan on macrophages especially M2 subtype. Our results demonstrated that fucoidan down-regulated partial cytokines and chemokines, especially a M2-type chemokine CCL22. Furthermore, fucoidan inhibited tumor cells migration and CD4 T lymphocytes, especially Treg cells, recruitment induced by M2 macrophages conditioned medium through suppression of CCL22. Mechanismly, fucoidan inhibited CCL22 via suppressing p65-NF-κB phosphorylation and nuclear translocation. In addition, p38-MAPK and PI3K-AKT also affected the expression of CCL22 through differential modulation of NF-κB transcriptional activity. Taken together, we reveal an interesting result that fucoidan can inhibit tumor cell migration and lymphocytes recruitment by suppressing CCL22 in M2 macrophages via NF-κB-dependent transcription, which may be a novel and promising mechanism for tumor immunotherapy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep35855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075786PMC
October 2016

Thoracoscopic Indocyanine Green Near-Infrared Fluorescence for Thoracic Sympathetic Ganglions.

Ann Thorac Surg 2016 Jun;101(6):2394

Department of Thoracic Surgery, Peking University People's Hospital, Beijing, China. Electronic address:

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.athoracsur.2016.02.030DOI Listing
June 2016

Nanoparticle Decorated Ultrathin Porous Nanosheets as Hierarchical Co3O4 Nanostructures for Lithium Ion Battery Anode Materials.

Sci Rep 2016 Feb 5;6:20592. Epub 2016 Feb 5.

Beijing National Center for Electron Microscopy, School of Materials Science and Engineering, The State Key Laboratory of New Ceramics and Fine Processing, Key Laboratory of Advanced Materials (MOE), Tsinghua University, Beijing 100084, China.

We report a facile synthesis of a novel cobalt oxide (Co3O4) hierarchical nanostructure, in which crystalline core-amorphous shell Co3O4 nanoparticles with a bimodal size distribution are uniformly dispersed on ultrathin Co3O4 nanosheets. When tested as anode materials for lithium ion batteries, the as-prepared Co3O4 hierarchical electrodes delivered high lithium storage properties comparing to the other Co3O4 nanostructures, including a high reversible capacity of 1053.1 mAhg(-1) after 50 cycles at a current density of 0.2 C (1 C = 890 mAg(-1)), good cycling stability and rate capability.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep20592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742879PMC
February 2016

[Clinical features and treatment outcome of multiple primary lung cancer patients with different imaging performance].

Zhonghua Wai Ke Za Zhi 2015 Oct;53(10):731-6

Department of Thoracic Surgery, Peking University People's Hospital, Beijing 100044, China; Email:

Objective: To analyze the clinical characteristics and follow up record of patients with synchronous multiple lung cancers (SMLC).

Methods: The medical records of 1 868 lung cancer patients who underwent surgical treatments From January 2007 to December 2014 were reviewed, in which 103 patients were diagnosed SMLC by Martini and American College of Chest Physicians modified guideline. The average age was 60.5 years, including 34 male and 69 female patients. According to consolidation/tumor ratio (CTR) on thin-section computed tomography, 103 cases were classified into three groups: group A (multiple ground-glass opacities, CTR ≤ 50%), group B (with one solid dominant nodules, CTR > 50%), group C (with two solid dominant nodules). The surgical procedure was determined according to CT findings and respiratory function. The Kaplan-Meier method was used to analyze the duration of recurrence-free survival (RFS) and over-all survival (OS), and differences were assessed using the Log-rank test. Multivariate analysis using the Cox proportional hazards models was used to assess the potential independent effects on RFS or OS.

Results: There were 38 patients in group A (36.9%), 40 patients in group B (38.8%) and 25 patients (24.3%) in group C. More female (73.7% vs. 48.0%, χ² = 4.291, P = 0.038), less smoker (21.1% vs. 44.0%, 2 = 3.770, P = 0.052), younger (56.2 years old vs. 65.9 years old, t = -4.172, P = 0.000) and less tumor size (1.24 cm vs. 2.31 cm, t = -4.573, P = 0.000) patients in group A than in group C. The 3, 5-year RFS were 80.3% and 64.9% for all patients, respectively. The 3, 5-year OS were 87.3% and 68.6% for all patients, respectively. The 3, 5-year RFS were 100% and 100% in group A, 77.7% and 51.8% in group B, 59.6% and 44.7% in group C (P = 0.029). No significance were found in OS between the three groups (P = 0.214). Multivariate Cox analysis demonstrated that size of dominant nodule larger than 2 cm (HR = 4.475, 95% CI: 1.138 to 17.604, P = 0.032) is associated with poor prognosis, whereas postoperative chemotherapy did not affect RFS.

Conclusions: Multifocal ground-glass opacities and multiple solid lung cancers are different in nature. RFS of patients with SMLC is strongly affected tumor size. Surgical resection is effective and should be performed specifically to patients.
View Article and Find Full Text PDF

Download full-text PDF

Source
October 2015

Assembly of multicomponent nanoframes via the synergistic actions of graphene oxide space confinement effect and oriented cation exchange.

Nanotechnology 2015 Nov 9;26(44):445601. Epub 2015 Oct 9.

School of Resources and Materials, Northeastern University at Qinhuangdao, Qinhuangdao 066004, People's Republic of China.

Multicomponent nanoframes (NFs) with a hollow structural character have shown the potential to be applied in many fields. Here we report a novel strategy to synthesize Zn x Cd1-x S NFs via the synergistic actions of the graphene oxide (GO) confinement effect and oriented cation exchange. The obtained samples have been systematically characterized by x-ray diffractometry (XRD), field-emission scanning electron microscopy (SEM), transmission electron microscopy (TEM), x-ray photospectroscopy (XPS) and Raman spectrometry. The results show that the two dimensional space confinement effect induced by GO and the oriented cation exchange reaction are responsible for the formation of the multicomponent NFs. The high photoelectrochemical activity and the low cost of the starting materials will make the multicomponent NFs applicable in photoelectronic and photoelectrocatalytic fields.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1088/0957-4484/26/44/445601DOI Listing
November 2015

Increased expression of surface CD44 in hypoxia-DCs skews helper T cells toward a Th2 polarization.

Sci Rep 2015 Sep 1;5:13674. Epub 2015 Sep 1.

Institute of Basic Medical Sciences, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China.

A low partial oxygen pressure (hypoxia) occurs in many pathological environments, such as solid tumors and inflammatory lesions. Understanding the cellular response to hypoxic stress has broad implications for human diseases. As we previously reported, hypoxia significantly altered dendritic cells (DCs) to a DC2 phenotype and promoted a Th2 polarization of naïve T cells with increased IL-4 production. However, the underlying mechanisms still remain largely unknown. In this study, we found the over-expression of surface CD44 in DCs was involved in this process via ligand binding. Further investigation showed hypoxia could reduce the surface expression of membrane type 1 metalloprotease (MT1-MMP) via down-regulating the kinesin-like protein KIF2A, which subsequently alleviated the shedding of CD44 from DCs. Moreover, KIF2A expression was found negatively regulated by HIF-1α in hypoxic microenvironment. These results suggest a previously uncharacterized mechanism by which hypoxia regulates the function of DCs via KIF2A/MT1-MMP/CD44 axis, providing critical information to understand the immune response under hypoxia.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep13674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555176PMC
September 2015

Overexpression of Class III β-tubulin, Sox2, and nuclear Survivin is predictive of taxane resistance in patients with stage III ovarian epithelial cancer.

BMC Cancer 2015 Jul 23;15:536. Epub 2015 Jul 23.

Department of Chemotherapy, Qilu Hospital of Shandong University, No. 107 Wenhuaxi road, Ji'nan, Shandong, 250012, China.

Background: Class III β-tubulin, Sox2, and Survivin play important roles in tumor survival and proliferation. However, the association of these three factors with clinicopathological characteristics, chemoresistance, and survival in patients with ovarian cancer remains controversial.

Methods: We investigated the predictive value and correlation among the expression levels of Class III β-tubulin, Sox2, and Survivin in 110 patients with stage III ovarian epithelial cancer, including 58 patients who received taxane-based chemotherapy and 52 patients who received non-taxane-based chemotherapy. Expression of these three factors was immunohistochemically examined in 110 ovarian tumor tissues obtained from patients before chemotherapy.

Results: The positive expression rates for Class III β-tubulin, Sox2, and Survivin in ovarian tumor tissues were 59.09 %, 61.82 % and 52.73 %, respectively. The expression of nuclear Survivin and Class III β-tubulin was consistent with that of Sox2 (p = 0.005 and 0.020, respectively). Positive expression of Class III β-tubulin, Sox2, and nuclear Survivin was significantly associated with chemoresistance to taxane-based chemotherapy (p = 0.006, 0.007, and 0.009, respectively), but not to non-taxane-based chemotherapy. Additionally, overexpression of Class III β-tubulin, Sox2, and nuclear Survivin predicted poor progression-free survival in patients receiving taxane-based chemotherapy (p = 0.032, 0.005, and 0.004, respectively).

Conclusions: These findings suggest that overexpression of Class III β-tubulin, Sox2, and nuclear Survivin might be predictive of taxane resistance and poor progression-free survival in patients with stage III ovarian epithelial cancer. Expression of these three factors may show positive correlations in these patients.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12885-015-1553-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511538PMC
July 2015

Sympathicotomy for palmar hyperhidrosis: the association between intraoperative palm temperature change and the curative effect.

Ann Thorac Cardiovasc Surg 2015 2;21(4):359-63. Epub 2015 Jun 2.

Department of Thoracic Surgery, Center of Thoracic Mini-invasive Surgery, Peking University People's Hospital, Beijing, 100044, China.

Purpose: To investigate the association between intraoperative palm temperature change and the curative effect of sympathicotomy.

Methods: 49 patients with palmar hyperhidrosis were treated with bilateral endoscopic sympathicotomy. Ipsilateral palm temperature was monitored before and at 3-5 min increments after the sympathetic trunk was transected. The maximum temperature elevation (Tmax) was calculated and used to evaluate the effect on postoperative cure rates.

Results: Forty-nine patients underwent 98 sympathicotomies. There were 77 T4 sympathicotomies, 15 T4 + T5 sympathicotomies, and six T3 sympathicotomies due to pleural adhesions or neurovascular proximity. The Tmax was ≤1°C in 49 (50.0%), 1-1.5°C in 17 (17.3%), and >1.5°C in 32 (32.7%) palms. Ninety-two palms of 46 patients were followed with complete efficacy, and three patients were lost to follow up. Cure was achieved in 86 palms (93.4%). Of the 71 palms which underwent T4 sympathicotomy, cure was achieved in 67 palms (94.3%). In those palms which did not achieve cure, the Tmax was less than 1°C in each case, while in palms with a Tmax ≤1°C, 32 of 36 (88.9%) were cured.

Conclusion: There is an association between intraoperative palmar temperature change and curative effect. However, palmar temperature change cannot be used to predict cure or guide surgical approach.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5761/atcs.oa.14-00270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904872PMC
June 2016