Yangchao Chen

Yangchao Chen

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Yangchao Chen

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Ectopic HOTTIP expression induces noncanonical transactivation pathways to promote growth and invasiveness in pancreatic ductal adenocarcinoma.

Cancer Lett 2020 May 28;477:1-9. Epub 2020 Feb 28.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, 518087, China. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2020.02.038DOI Listing
May 2020

Activation of PTEN by inhibition of TRPV4 suppresses colon cancer development.

Cell Death Dis 2019 06 12;10(6):460. Epub 2019 Jun 12.

School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.

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http://dx.doi.org/10.1038/s41419-019-1700-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561944PMC
June 2019

Genome-Wide Screening and Functional Analysis Identifies Tumor Suppressor Long Noncoding RNAs Epigenetically Silenced in Hepatocellular Carcinoma.

Cancer Res 2019 04 4;79(7):1305-1317. Epub 2019 Feb 4.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-1659DOI Listing
April 2019

Berberine induces miR-373 expression in hepatocytes to inactivate hepatic steatosis associated AKT-S6 kinase pathway.

Eur J Pharmacol 2018 Apr 22;825:107-118. Epub 2018 Feb 22.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong; CUHK Shenzhen Research Institute, Shenzhen, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2018.02.035DOI Listing
April 2018

Identification of Small Molecule Modulators of MicroRNA by Library Screening.

Methods Mol Biol 2017 ;1517:169-178

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1007/978-1-4939-6563-2_12DOI Listing
January 2018

EZH2 coupled with HOTAIR to silence MicroRNA-34a by the induction of heterochromatin formation in human pancreatic ductal adenocarcinoma.

Int J Cancer 2017 Jan 19;140(1):120-129. Epub 2016 Sep 19.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.

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http://dx.doi.org/10.1002/ijc.30414DOI Listing
January 2017

Small molecule targeting miR-34a for cancer therapy.

Mol Cell Oncol 2015 Jan-Mar;2(1):e977160. Epub 2015 Feb 24.

School of Biomedical Sciences; Faculty of Medicine; The Chinese University of Hong Kong; Shatin, Hong Kong; State Key Laboratory of Digestive Disease; Institute of Digestive Disease; The Chinese University of Hong Kong; Shatin, Hong Kong; Shenzhen Research Institute; The Chinese University of Hong Kong; Shenzhen, China.

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http://dx.doi.org/10.4161/23723556.2014.977160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905251PMC
June 2016

Overexpression of GOLPH3 is associated with poor survival in Non-small-cell lung cancer.

Am J Transl Res 2016 15;8(4):1756-62. Epub 2016 Apr 15.

Department of Medical Oncology, Key Laboratory of Biotherapy in Zhejiang, Sir Runrun Shaw Hospital, Medical School of Zhejiang University China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859904PMC
May 2016

Diagnostic Potential of lncRNAs in Cancer.

EBioMedicine 2016 05 12;7:7-8. Epub 2016 May 12.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China; State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, NT, Hong Kong. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909482PMC
May 2016

Targeting EZH2 for cancer therapy: progress and perspective.

Curr Protein Pept Sci 2015 ;16(6):559-70

School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, NT, Hong Kong.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997953PMC
http://dx.doi.org/10.2174/1389203716666150409100233DOI Listing
April 2016

Hepatitis C virus NS5A protein cooperates with phosphatidylinositol 4-kinase IIIα to induce mitochondrial fragmentation.

Sci Rep 2016 Mar 24;6:23464. Epub 2016 Mar 24.

School of Biomedical Sciences and The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, P.R. China.

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http://dx.doi.org/10.1038/srep23464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806301PMC
March 2016

Marine natural products with anti-inflammatory activity.

Appl Microbiol Biotechnol 2016 Feb 28;100(4):1645-1666. Epub 2015 Dec 28.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1007/s00253-015-7244-3DOI Listing
February 2016

Small and Long Non-Coding RNAs: Novel Targets in Perspective Cancer Therapy.

Curr Genomics 2015 Oct;16(5):319-26

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong;; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China;; State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.

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http://dx.doi.org/10.2174/1389202916666150707155851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763970PMC
October 2015

Truncated HBx-dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53-mediated apoptosis.

J Pathol 2015 Sep 28;237(1):38-49. Epub 2015 May 28.

Institute of Digestive Disease and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, SAR, China.

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http://dx.doi.org/10.1002/path.4554DOI Listing
September 2015

Effect of Berberine on promoting the excretion of cholesterol in high-fat diet-induced hyperlipidemic hamsters.

J Transl Med 2015 Aug 27;13:278. Epub 2015 Aug 27.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, 100050, China.

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http://dx.doi.org/10.1186/s12967-015-0629-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549888PMC
August 2015

Transforming berberine into its intestine-absorbable form by the gut microbiota.

Sci Rep 2015 Jul 15;5:12155. Epub 2015 Jul 15.

1] State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing 100050, China [2] Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing 100050, China.

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http://dx.doi.org/10.1038/srep12155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502414PMC
July 2015

Epigenetic silencing of miR-490-3p reactivates the chromatin remodeler SMARCD1 to promote Helicobacter pylori-induced gastric carcinogenesis.

Cancer Res 2015 Feb 12;75(4):754-65. Epub 2014 Dec 12.

School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong. Institute of Digestive Disease and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1301DOI Listing
February 2015

B cell CLL/lymphoma 6 member B inhibits hepatocellular carcinoma metastases in vitro and in mice.

Cancer Lett 2014 Dec 11;355(2):192-200. Epub 2014 Sep 11.

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, Shenzhen Research Insititute, The Chinese University of Hong Kong, Hong Kong. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2014.08.025DOI Listing
December 2014

A small-molecule modulator of the tumor-suppressor miR34a inhibits the growth of hepatocellular carcinoma.

Cancer Res 2014 Nov 12;74(21):6236-47. Epub 2014 Sep 12.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong. State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, NT, Hong Kong. Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0855DOI Listing
November 2014

Hepatitis B virus X protein promotes hepatocellular carcinoma transformation through interleukin-6 activation of microRNA-21 expression.

Eur J Cancer 2014 Oct 30;50(15):2560-9. Epub 2014 Jul 30.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518057, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2014.07.008DOI Listing
October 2014

β-arrestin2/miR-155/GSK3β regulates transition of 5'-azacytizine-induced Sca-1-positive cells to cardiomyocytes.

J Cell Mol Med 2014 Aug 26;18(8):1562-70. Epub 2014 Jun 26.

Institute of Developmental Biology, School of Life Science, Shandong University, Jinan, China; Department of Internal Medicine, College of Medicine, East Tennessee State University, Johnson City, TN, USA.

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http://dx.doi.org/10.1111/jcmm.12339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190902PMC
August 2014

Biotransformation and in vitro metabolic profile of bioactive extracts from a traditional Miao-nationality herbal medicine, Polygonum capitatum.

Molecules 2014 Jul 16;19(7):10291-308. Epub 2014 Jul 16.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China.

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http://dx.doi.org/10.3390/molecules190710291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270779PMC
July 2014

Role of microRNA-95 in the anticancer activity of Brucein D in hepatocellular carcinoma.

Eur J Pharmacol 2014 Apr 11;728:141-50. Epub 2014 Feb 11.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518057, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2014.02.002DOI Listing
April 2014

A potential antitumor ellagitannin, davidiin, inhibited hepatocellular tumor growth by targeting EZH2.

Tumour Biol 2014 Jan 30;35(1):205-12. Epub 2013 Jul 30.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, 100050, China.

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http://dx.doi.org/10.1007/s13277-013-1025-3DOI Listing
January 2014

Inhibition of bone morphogenic protein 4 restores endothelial function in db/db diabetic mice.

Arterioscler Thromb Vasc Biol 2014 Jan 7;34(1):152-9. Epub 2013 Nov 7.

From the Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences (Y.Z., L.W., J.L., W.S.C., C.W.L., X.Y., Y.H.), School of Biomedical Sciences (J.L., Y.C., X.Y., Y.H.), School of Life Sciences (K.M.K.), Chinese University of Hong Kong, Hong Kong SAR, China; Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX (X.Y.T., W.T.W.); and Institute of Cardiovascular Sciences, Peking University Health Science Center, Beijing, China (N.W.).

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http://atvb.ahajournals.org/content/34/1/152.full.pdf
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http://atvb.ahajournals.org/cgi/doi/10.1161/ATVBAHA.113.3026
Publisher Site
http://dx.doi.org/10.1161/ATVBAHA.113.302696DOI Listing
January 2014

Targeting long non-coding RNAs in cancers: progress and prospects.

Int J Biochem Cell Biol 2013 Aug 4;45(8):1895-910. Epub 2013 Jun 4.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1016/j.biocel.2013.05.030DOI Listing
August 2013

Enhancer of zeste homolog 2 silences microRNA-218 in human pancreatic ductal adenocarcinoma cells by inducing formation of heterochromatin.

Gastroenterology 2013 May 7;144(5):1086-1097.e9. Epub 2013 Feb 7.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1053/j.gastro.2013.01.058DOI Listing
May 2013

Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway.

J Mol Cell Cardiol 2012 Jan 25;52(1):237-44. Epub 2011 Oct 25.

Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.1016/j.yjmcc.2011.10.013DOI Listing
January 2012

Revisit complexation between DNA and polyethylenimine - Effect of uncomplexed chains free in the solution mixture on gene transfection.

J Control Release 2011 Oct 3;155(1):67-76. Epub 2010 Nov 3.

Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.

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http://dx.doi.org/10.1016/j.jconrel.2010.10.028DOI Listing
October 2011

RNAi targeting EZH2 inhibits tumor growth and liver metastasis of pancreatic cancer in vivo.

Cancer Lett 2010 Nov 1;297(1):109-16. Epub 2010 Jun 1.

The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1016/j.canlet.2010.05.003DOI Listing
November 2010

Proteomic identification of microRNA-122a target proteins in hepatocellular carcinoma.

Proteomics 2010 Oct;10(20):3723-31

Department of Chemistry, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1002/pmic.201000050DOI Listing
October 2010

Microarray profile of brain aging-related genes in the frontal cortex of SAMP8.

J Mol Neurosci 2010 May 17;41(1):12-6. Epub 2009 Oct 17.

Department of Anatomy, Kunming Medical College, Kunming, Yunnan, People's Republic of China.

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http://dx.doi.org/10.1007/s12031-009-9215-6DOI Listing
May 2010

Dynamic transcriptional changes of TIEG1 and TIEG2 during mouse tissue development.

Anat Rec (Hoboken) 2010 May;293(5):858-64

Institute of Cell Biology, Zhejiang University, Hangzhou, People's Republic of China.

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http://dx.doi.org/10.1002/ar.21108DOI Listing
May 2010

Revisit the complexation of PEI and DNA - how to make low cytotoxic and highly efficient PEI gene transfection non-viral vectors with a controllable chain length and structure?

J Control Release 2009 Nov 19;140(1):40-6. Epub 2009 Jul 19.

Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.

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http://dx.doi.org/10.1016/j.jconrel.2009.07.009DOI Listing
November 2009

Adenosine diphosphate-ribosylation factor 6 is required for epidermal growth factor-induced glioblastoma cell proliferation.

Cancer 2009 Nov;115(21):4959-72

Department of Chemistry, Open Laboratory of Chemical Biology, the University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1002/cncr.24550DOI Listing
November 2009

HIV-1 gp120 primes lymphocytes for opioid-induced, beta-arrestin 2-dependent apoptosis.

Biochim Biophys Acta 2009 Aug 27;1793(8):1366-71. Epub 2009 May 27.

Departments of Internal Medicine, College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.

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http://dx.doi.org/10.1016/j.bbamcr.2009.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716560PMC
August 2009

High level virion production and surface antigen expression with 1.5 copies of hepatitis B viral genome.

J Virol Methods 2009 Aug 21;159(2):135-40. Epub 2009 Mar 21.

Stanley Ho Centre for Emerging Infectious Diseases, School of Public Health, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1016/j.jviromet.2009.03.012DOI Listing
August 2009

microRNA-146b inhibits glioma cell migration and invasion by targeting MMPs.

Brain Res 2009 May 3;1269:158-65. Epub 2009 Mar 3.

Integrative Chemical Biology Laboratory, Institute of Molecular Technology, Department of Chemistry, The University of Hong Kong, Pokfulam, Hong Kong, China.

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https://linkinghub.elsevier.com/retrieve/pii/S00068993090037
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http://dx.doi.org/10.1016/j.brainres.2009.02.037DOI Listing
May 2009

MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells.

Biochem Biophys Res Commun 2009 Mar 9;380(2):205-10. Epub 2009 Jan 9.

Integrative Chemical Biology Laboratory, Institute of Molecular Technology, Department of Chemistry, 8/F, Kadoorie Biological Science Building, The University of Hong Kong, Pokfulam Road, Hong Kong, China.

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http://dx.doi.org/10.1016/j.bbrc.2008.12.169DOI Listing
March 2009

Down-regulation of stathmin is required for TGF-beta inducible early gene 1 induced growth inhibition of pancreatic cancer cells.

Cancer Lett 2009 Feb 18;274(1):101-8. Epub 2008 Oct 18.

Institute of Cell Biology, Zhejiang University, Hangzhou, 310058, Zhejiang Province, People's Republic of China.

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http://linkinghub.elsevier.com/retrieve/pii/S030438350800717
Publisher Site
http://dx.doi.org/10.1016/j.canlet.2008.09.017DOI Listing
February 2009

Proteomic identification of molecular targets of gambogic acid: role of stathmin in hepatocellular carcinoma.

Proteomics 2009 Jan;9(2):242-53

State Key Laboratory of Oncology in Southern China and Stanley Ho Center for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1002/pmic.200800155DOI Listing
January 2009

A1762T/G1764A mutations of hepatitis B virus, associated with the increased risk of hepatocellular carcinoma, reduce basal core promoter activities.

Biochem Biophys Res Commun 2008 Oct 8;374(4):773-6. Epub 2008 Aug 8.

Stanley Ho Centre for Emerging Infectious Diseases and Li Ka Shing Institute of Health Sciences, School of Public Health, Prince of Wales Hospital, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.

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http://dx.doi.org/10.1016/j.bbrc.2008.07.115DOI Listing
October 2008

Transcriptional regulation of corticotrophin releasing factor gene by furocoumarins isolated from seeds of Psoralea corylifolia.

Life Sci 2008 May 1;82(21-22):1117-21. Epub 2008 Apr 1.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1016/j.lfs.2008.03.014DOI Listing
May 2008

Proteomic analysis of EZH2 downstream target proteins in hepatocellular carcinoma.

Proteomics 2007 Sep;7(17):3097-104

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1002/pmic.200700019DOI Listing
September 2007

Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro.

Cancer Res 2003 Aug;63(16):4801-4

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington 98195, USA.

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August 2003

Functional interplay between CBP and PCAF in acetylation and regulation of transcription factor KLF13 activity.

J Mol Biol 2003 May;329(2):207-15

Division of Medical Genetics, Department of Medicine, School of Medicine, University of Washington, Seattle 98195-7720, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808423PMC
http://dx.doi.org/10.1016/s0022-2836(03)00429-7DOI Listing
May 2003

Transcription coactivator CBP has direct DNA binding activity and stimulates transcription factor DNA binding through small domains.

Biochem Biophys Res Commun 2002 Aug;296(1):118-24

Division of Medical Genetics, Department of Medicine, University of Washington, Box 357720, 1705 NE Pacific Streets, 98195, Seattle, WA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808418PMC
http://dx.doi.org/10.1016/s0006-291x(02)00842-2DOI Listing
August 2002