Publications by authors named "Yangang Wang"

177 Publications

Engineering of anatase/rutile TiO heterophase junction via in-situ phase transformation for enhanced photocatalytic hydrogen evolution.

J Colloid Interface Sci 2021 Oct 28;599:795-804. Epub 2021 Apr 28.

College of Biological Chemical Science and Engineering, Jiaxing University, Jiaxing 314001, China. Electronic address:

Constructing effective interphase boundary is one of the efficient approaches for improving photocatalytic performances of semiconductor materials. In this work, an anatase/rutile-TiO (AR-TiO) heterophase junction with appropriate carbon content was successfully fabricated via an in-situ phase transformation process. The phase transformation started from the inner core of the nanoparticles and the area of phase interface between anatase and rutile was carefully controlled by regulating the activation temperature. The well-established type-II band alignment between two TiO phases with residual carbon as additional charge transfer intermediary which significantly improved the light-harvesting and photoinduced electron-hole pair separation. As a result, the optimal AR-TiO-550 catalyst (without adding commonly used Pt as co-catalyst) remarkably enhanced photocatalytic H generation (201 μmol h g), which was about 12-fold to that of P25. The AR-TiO-550 heterophase junction also showed long-term stability under simulated solar light irradiation. This research provides a new phase engineering route for developing high-efficient photocatalysts.
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http://dx.doi.org/10.1016/j.jcis.2021.04.127DOI Listing
October 2021

Arming wood carbon with carbon-coated mesoporous nickel-silica nanolayer as monolithic composite catalyst for steam reforming of toluene.

J Colloid Interface Sci 2021 Oct 30;599:650-660. Epub 2021 Apr 30.

College of Biological Chemical Science and Engineering, Jiaxing University, Jiaxing, Zhejiang 314001, China. Electronic address:

Steam reforming is an effective measure for biomass tar elimination as well as H-rich syngas (H + CO) production. However, the granular or powdery Ni-based catalysts are prone to deactivation, which is caused by inappropriate mass transfer and clogging of catalyst bed. Herein, monolithic wood carbon (WC) with low-tortuosity microchannels is armed with a carbon-coated mesoporous nickel-silica nanocomposite ([email protected]) layer via an evaporation-induced self-assembly and calcination procedure for toluene (tar model compound) steam reforming. The quality of the [email protected] layer growing on the surface of WC microchannel is affected by the molar ratios of Si/Ni feed. A uniform thin-layer coverage is obtained on the [email protected]/WC (Si/Ni = 15) catalyst, where highly dispersed Ni nanoparticles (average size of 6.6 nm) with appropriate metal-support interaction and remarkable mechanical strength are achieved. The mass transfer, coke resistance, and hydrothermal stability of the [email protected]/WC catalyst were significantly improved by the multilevel structure assembled from the WC microchannels and the secondary ordered SiO mesopores. A stable toluene conversion over 97% with an H yield of 135 μmol/min was obtained at 600 °C on the [email protected]/WC catalyst. This work opens a new window for facilely constructing high-performance wood carbon-based monolithic tar reforming catalyst.
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http://dx.doi.org/10.1016/j.jcis.2021.04.112DOI Listing
October 2021

Construction of hierarchically porous biomass carbon using iodine as pore-making agent for energy storage.

J Colloid Interface Sci 2021 Oct 24;599:351-359. Epub 2021 Apr 24.

College of Biological, Chemical Science and Engineering, Jiaxing University, Jiaxing 314001, China. Electronic address:

High specific surface area, hierarchical porosity, high conductivity and heteroatoms doping have been considered as the dominating factors of high-performance carbon-based supercapacitors. Inspired by the blue phenomenon of combination of starch and iodine, iodine is employed firstly as pore-making agent to create micropores for the starch-derived carbon in this study. Based on this mechanism, the hierarchically porous carbon is synthesized through simple solvent heating and high-temperature (1000 °C) carbonization, which achieves high specific surface area of 2989 m g (an increase of 39.7% compared to that without iodine) and low electrical resistivity of 0.21 Ω·cm. The assembled symmetric supercapacitors, combined with dual redox-active electrolyte (Bi and Br), deliver the specific capacitance of 1216 F g, energy density of 65.4 Wh kg, as well as power density of 787.3 W kg at 2 A g. In brief, the abundant biomass resource starch is exploited as carbon source, and the iodine sublimation reaction is conducted to provide more micropores to develop high-performance electrodes of supercapacitors.
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http://dx.doi.org/10.1016/j.jcis.2021.04.108DOI Listing
October 2021

Determination of the protective effects of Hua-Zhuo-Jie-Du in chronic atrophic gastritis by regulating intestinal microbiota and metabolites: combination of liquid chromatograph mass spectrometer metabolic profiling and 16S rRNA gene sequencing.

Chin Med 2021 May 1;16(1):37. Epub 2021 May 1.

Hebei University of Chinese Medicine, Xinshi South Road No 326, Qiaoxi District, Hebei, 050091, Shijiazhuang, China.

Background: Hua-Zhuo-Jie-Du (HZJD), a Chinese herbal prescription consisting of 11 herbs, is commonly used in China to treat chronic atrophic gastritis (CAG). We aimed to determine the effect of HZJD on the microbiome-associated metabolic changes in CAG rats.

Methods: The CAG rat models were induced by 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) combined with irregular fasting and 2% sodium salicylate, which was intragastrically administrated in fasted animals for 24 weeks. The CAG rats in the Chinese medicine (CM) group were administered a daily dose of 14.81 g/kg/day HZJD, and the vitacoenzyme (V) group were administered a daily dose of 0.08 g/kg/day vitacoenzyme. All animals were treated for 10 consecutive weeks, consecutively. Hematoxylin and eosin (H&E) staining was used to assess the histopathological changes in the gastric tissues. An integrated approach based on liquid chromatograph mass spectrometer (LC-MS) metabolic profiling combined with 16S rRNA gene sequencing was carried out to assess the effects of HZJD on CAG rats. Spearman analysis was used to calculate the correlation coefficient between the different intestinal microbiota and the metabolites.

Results: The H&E results indicated that HZJD could improve the pathological condition of CAG rats. The LC-MS results indicated that HZJD could significantly improve 21 gastric mucosal tissue perturbed metabolites in CAG rats; the affected metabolites were found to be involved in multiple metabolic pathways, such as the central carbon metabolism in cancer. The results of 16S rRNA gene sequencing indicated that HZJD could regulate the diversity, microbial composition, and abundance of the intestinal microbiota of CAG rats. Following HZJD treatment, the relative abundance of Turicibacter was increased, and the relative abundance of Desulfococcus and Escherichia were decreased in the CM group when compared with the M group. Spearman analysis revealed that perturbed intestinal microbes had a strong correlation with differential metabolites, Escherichia exhibited a negative correlation with l-Leucine, Turicibacter was negatively correlated with urea, and Desulfococcus exhibited a positive correlation with trimethylamine, and a negative correlation with choline.

Conclusions: HZJD could protect CAG by regulating intestinal microbiota and its metabolites.
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http://dx.doi.org/10.1186/s13020-021-00445-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088729PMC
May 2021

Molecular and clinical characteristics of congenital hypothyroidism in a large cohort study based on comprehensive thyroid transcription factor mutation screening in Henan.

Clin Chim Acta 2021 Jul 24;518:162-169. Epub 2021 Mar 24.

Department of Henan Newborn Screening Center, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address:

Background: Congenital hypothyroidism (CH), the most common neonatal endocrine disorder worldwide, can be caused by variants in thyroid transcription factor (TTF) genes including NKX2-1, FOXE1, PAX8, NKX2-5 and HHEX. This study aims to perform targeted next-generation sequencing (NGS) panel for comprehensive mutation screening on these genes in a cohort of 606 CH patients with various types from Henan Province, China, to investigate the mutation rate of TTF genes, and to analyze the clinical, biochemical and molecular characteristics of our CH cohort.

Methods: High-throughput sequencing combined with statistical calculation were applied for mutation screening and analyses of the clinical data.

Results: Twenty-two likely disease-causing monoallelic mutations in the TTF genes were identified in our cohort (3.63%, 22/606). Mutated PAX8 was the most predominant genetic alteration among these TTF mutations. Interestingly, PAX8 defects were only found in TD cases and variants in the five TTF genes were detected in gland in situ (GIS) patients. CH patients with the same genotype may have significant phenotypic variability and permanent CH (PCH) patients in the GIS group were significantly fewer than those in the TD group.

Conclusions: Our study showed the estimated TTF mutation rate among CH cases was 3.63% in Henan Province and genetic alternations in TTF genes played a role not only in TD but also in GIS, especially in goiter. Although we speculated that the five TTF genes may be involved in certain steps of thyroid hormone biosynthesis, more researches are needed to verify the conclusions of the present study.
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http://dx.doi.org/10.1016/j.cca.2021.03.015DOI Listing
July 2021

MiR-223-3p and miR-22-3p inhibit monosodium urate-induced gouty inflammation by targeting NLRP3.

Int J Rheum Dis 2021 Apr 1;24(4):599-607. Epub 2021 Mar 1.

Department of Endocrinology, Affiliated Hospital of Medical College Qingdao University, Qingdao, China.

Background: MicroRNAs (miRNAs) have been shown to play a crucial role in inflammation regulation; however, their relationship with inflammation in acute gouty arthritis has not been fully elucidated. Herein, we conducted a study to explore the regulatory roles of miR-223-3p and miR-22-3p in gouty-associated inflammation.

Methods: In vitro and in vivo experiments were conducted to examine the molecular mechanisms of miRNA regulation in gouty inflammation. Dual-luciferase reporter assay was used to verify the direct target of miR-223-3p and miR-22-3p.

Results: We found that miR-223-3p and miR-22-3p interacted with the 3' untranslated region segment of NLRP3 (nucleotide-binding domain leucine-rich repeat [NLR] and pyrin domain containing receptor 3) and inhibited its expression. A decreased expression of miR-223-3p and miR-22-3p was observed in both mice air pouch synovium and phorbol myristrate acetate-treated THP-1 cells stimulated with monosodium urate (P < .05). Compared with the negative control group, NLRP3 expression at the transcript and protein level in miR-223-3p and miR-22-3p overexpression group significantly decreased after 6 hours of monosodium urate treatment in vivo and in vitro (P < .05). The results of the dual-luciferase reporter assay demonstrated that miR-223-3p and miR-22-3p directly targeted NLRP3.

Conclusion: The findings of the present study show that miR-223-3p and miR-22-3p can reduce the inflammatory effects of gout by inhibiting the expression of NLRP3.
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http://dx.doi.org/10.1111/1756-185X.14089DOI Listing
April 2021

Generation of a gene-corrected isogenic iPSC line (AHQUi001-A-1) from a patient with familial hypertriglyceridemia (FHTG) carrying a heterozygous p.C310R (c.928 T > C) mutation in LPL gene using CRISPR/Cas9.

Stem Cell Res 2021 Apr 11;52:102230. Epub 2021 Feb 11.

Department of Endocrinology and Metabolic Diseases, The Affiliated Hospital of Qingdao University, Qingdao 266003, China. Electronic address:

Mutations in the LPL gene lead to familial hypertriglyceridemia (FHTG) . We have previously generated an iPSC line (AHQUi001-A) from a FHTG patient with a heterozygous p.C310R (c.928 T > C) mutation in the LPL gene. Here we genetically corrected the C310R mutation in the LPL gene using CRISPR/Cas9 technology to generate AHQUi001-A-1, which demonstrates normal karyotype, morphology, pluripotency, and potential to differentiate towards three germ layers.
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http://dx.doi.org/10.1016/j.scr.2021.102230DOI Listing
April 2021

Controllable synthesis of nitrogen-doped carbon containing Co and CoFe nanoparticles as effective catalysts for electrochemical oxygen conversion.

J Colloid Interface Sci 2021 May 2;590:622-631. Epub 2021 Feb 2.

Department of Environmental Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address:

Sufficient and well-distributed active sites and highly conductive carbon matrix are two important factors to achieve highly efficient electrocatalysts. In this study, we report an adjusted metal-organic frameworks (MOF)-based route for the preparation of nitrogen-doped Fe/Co bimetallic electrocatalysts. With suitable Fe/Co molar ratio (Fe/Co = 1/4.15), Co nanoparticles (NPs) with mild oxidation state and CoFe alloys wrapped with thin graphene layers are embedded in an integrated and continuous carbon network. The corresponding [email protected] catalyst exhibits excellent oxygen reduction reaction (ORR) activity (onset potential (E) of 0.94 V and half-wave potential (E) of 0.84 V vs RHE) in alkaline medium, close to commercial Pt/C and superior to the other two [email protected] The desirable ORR performance results from the uniform distribution CoFe active sites, electron density modification from Co NPs to surrounding carbon layers, hierarchical pore structure with large surface area, low carbon content, high pyridinic and graphitic N components. The [email protected] also displays satisfactory methanol crossover tolerance and durability.
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http://dx.doi.org/10.1016/j.jcis.2021.01.097DOI Listing
May 2021

A comparative study of acarbose, vildagliptin and saxagliptin intended for better efficacy and safety on type 2 diabetes mellitus treatment.

Life Sci 2021 Jun 15;274:119069. Epub 2021 Jan 15.

Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao 266000, PR China. Electronic address:

As a complicated metabolic disorder, type 2 diabetes mellitus (T2DM) is becoming a major health concern worldwide. Drugs including acarbose, saxagliptin and vildagliptin are applied, but their efficacy is still required to be compared. Therefore, the study aimed to evaluate the efficacy and safety of acarbose, saxagliptin and vildagliptin in the treatment of T2DM. Ninety patients diagnosed with T2DM were treated with acarbose, saxagliptin and vildagliptin, respectively (30 patients for each drug). All patients were examined at 0, 4 and 12 weeks after treatment with vital signs recorded. Fasting blood glucose and blood biochemical indices were analyzed. In addition, fecal samples were taken for microbial macrogenome sequencing and safety evaluation within 12 weeks after treatment. Blood glucose level decreased at 4 and 12 weeks after treatment, and the total cholesterol (TC) and high-density lipoprotein (HDL) levels at 12 weeks were different. Genus abundance of intestinal flora was altered at different time points. Acarbose increased Butyricimonas level first and then decreased it during drug treatment. Saxagliptin increased Megamonas and decreased Turicibacter genus level gradually. Pseudomonas, Klebsiella, Blautia, Faecalibacterium and Roseburia levels fluctuated after Vildagliptin treatment, which increased fasting C-peptide level greater than the other two drugs. Saxagliptin showed higher adverse reactions than acarbose and vildagliptin. Collectively, acarbose, vildagliptin, and saxagliptin can effectively reduce the HbA1c level and affect the intestinal flora distribution in T2DM patients, and the adverse reactions of acarbose and vildagliptin are less than saxagliptin, providing alternative strategies for the treatment of T2DM.
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http://dx.doi.org/10.1016/j.lfs.2021.119069DOI Listing
June 2021

Integrating Network Pharmacology and Experimental Validation to Investigate the Mechanisms of Huazhuojiedu Decoction to Treat Chronic Atrophic Gastritis.

Evid Based Complement Alternat Med 2020 7;2020:2638362. Epub 2020 Dec 7.

The First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang 050011, China.

Background: Chronic atrophic gastritis (CAG) is an important stage in the normal gastric mucosa's transformation into gastric cancer. Huazhuojiedu decoction (HZJD), a Chinese herbal preparation, has proven clinically effective to treat CAG. However, few studies have explored the mechanism of HZJD in CAG treatment.

Purpose: This study aimed to shed light on the mechanisms underlying HZJD decoction CAG treatment using a network pharmacology approach and experimental validation.

Methods: The active components of HZJD decoction were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform. Their targets were predicted through the SwissTargetPrediction database. Disease targets were screened using the GeneCards database. The disease and drug prediction targets were intersected to select the common potential therapeutic targets, which then were input into the Search Tool for the Retrieval of Interacting Genes to build a protein-protein interaction network. The "herb-compound-target-disease" and the "herb-target-pathway" network diagrams were constructed in Cytoscape 3.3.0. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of effective targets were performed using the Database for Annotation, Visualization, and Integrated Discovery. Finally, the core targets were preliminarily verified by CAG rat model. The gastric mucosa's histopathological changes were observed via hematoxylin-eosin staining. The expressions of MAPK1, AKT1, TNF, VEGFA, and EGFR were detected by western blot and quantitative real-time reverse transcription-polymerase chain reaction.

Results: A total of 155 nodes, including 20 putative targets of HZJD decoction, were selected as core hubs based on topological importance and were closely associated with the regulation of cell proliferation, apoptotic process, and cancer-related pathways (AKT1, TNF, VEGFA, and EGFR) in CAG. Further animal experiments showed that the expression of AKT1 in CAG rats was significantly increased, which was suppressed by HZJD decoction. TNF and VEGFA expression increased in the model group, but did not change in the HZJD group. MAPK1 and EGFR expression showed no significant differences among control, model, and HZJD groups.

Conclusion: Taken together, the results suggest that the components of HZJD decoction can alleviate and prevent the severity of gastric precancerous lesions via AKT1 inhibition in CAG.
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http://dx.doi.org/10.1155/2020/2638362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735863PMC
December 2020

Enhanced flux and fouling resistance forward osmosis membrane based on a hydrogel/MOF hybrid selective layer.

J Colloid Interface Sci 2021 Mar 25;585:158-166. Epub 2020 Nov 25.

Department of Environmental Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address:

Although forward osmosis (FO) technology has been widely adopted for water treatment, it still faces great challenges, including low permeability and fouling problem. Herein, a novel forward osmosis membrane was developed with a stable, uniform and defect-free polyvinyl alcohol/polydopamine coated zeolitic imidazolate framework (PVA/[email protected]) hybrid selective layer to simultaneously enhance its transport property and fouling resistance. The prepared FO membrane exhibits improved water flux without losing the selectivity, since the [email protected] provide additional preferential passageway for water transporting while hinder the diffusion of salt. The optimized membrane shows a higher water flux than pristine PVA membrane (14.2 vs. 8.7 L m h in FO mode, 24.3 vs. 14.8 L m h in PRO mode) with a reasonable selectivity considering as J/J value (0.44 vs. 0.4 g L in FO mode, 0.38 vs. 0.33 g L). Moreover, the dynamic fouling experiments with organic foulants (protein and polysaccharide) indicate that the prepared membrane exhibits strong antifouling property and excellent permeation recovery ability (>95.0%) due to the optimized surface property. This study opens a new avenue for treatment wastewater by developing a forward osmosis membrane based on a hydrogel/MOF hybrid selective layer.
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http://dx.doi.org/10.1016/j.jcis.2020.11.092DOI Listing
March 2021

Serum progesterone and retinopathy in male patients with type 2 diabetes: A cross-sectional study.

J Diabetes Investig 2020 Nov 17. Epub 2020 Nov 17.

Department of Endocrinology, Affiliated Hospital of Medical College Qingdao University, Qingdao, China.

Aims/introduction: The aim of this study was to investigate the relationship between serum progesterone (P) and retinopathy in male patients with type 2 diabetes mellitus, and to investigate whether P is associated with its progression.

Materials And Methods: A total of 1,376 male participants with type 2 diabetes mellitus were recruited from Affiliated Hospital of Medical College Qingdao University (Qingdao, China). Through logistic regression analysis after adjusting the potential confounding variation, the odds ratio (OR) and the corresponding 95% confidence interval related to the quartiles of progesterone were obtained.

Results: According to the quartiles of P levels, the prevalence rate of diabetic retinopathy (DR) in the last quartile is obviously greater to other quartiles (52.5-34.9%, 31.9%, 37.5%, P < 0.001). Compared with those in the first quartile, the prevalence of DR for the last quartile had an OR of 1.85 in the non-proliferative diabetic retinopathy group, while the OR was 8.35 in the proliferative diabetic retinopathy group (P < 0.001, unadjusted model). When adjusted for age, body mass index, duration of type 2 diabetes mellitus, glycated hemoglobin, blood pressure and other variables, the ORs for DR in the fourth quartile were 2.13 (95% confidence interval 1.49-3.06) in the non-proliferative diabetic retinopathy group and 8.44 (95% confidence interval 2.69-26.43) in the proliferative diabetic retinopathy group (P < 0.001). The positive association between P and DR risk was independent in adjusted logistic regression.

Conclusions: High levels of serum progesterone are significantly associated with DR in male hospitalized patients. This could mean that a higher P level in men is a potential clinical factor to identify DR, and the causality remains to be further explored.
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http://dx.doi.org/10.1111/jdi.13463DOI Listing
November 2020

Normal parathyroid hormone and non-proliferative diabetic retinopathy in patients with type 2 diabetes.

J Diabetes Investig 2020 Nov 1. Epub 2020 Nov 1.

Department of Endocrinology, Affiliated Hospital of Medical College Qingdao University, Qingdao, China.

Aims/introduction: To investigate the associations between parathyroid hormone (PTH) and non-proliferative diabetic retinopathy (NPDR) in patients with type 2 diabetes mellitus.

Materials And Methods: Data were collected from 2,322 patients with type 2 diabetes mellitus in hospital between 2017 and 2019. The odds ratio (OR) and the corresponding 95% confidence interval related to the quartiles of PTH were obtained by logistic regression analysis after adjusting the potential confounding variation.

Results: The patients were stratified into quartiles (Q1-Q4) based on the PTH levels, with the cut-off limits of ≤23.74, 23.74-29.47, 29.47-37.30 and >37.30 pg/mL in men, and ≤24.47, 24.47-31.22, 31.22-39.49 and >39.49 pg/mL in women. The first quartile (Q1) represents the lowest quartile and the fourth quartile (Q4) is the highest. According to the quartiles (Q1-Q4), the prevalence rate of NPDR in patients showed a significantly decreasing trend (37.9%, 36.3%, 34.0% vs 24.0% in men; 43.2%, 40.5%, 31.1% vs 26.2% in women, both P < 0.05). Independent of age, diabetes duration and other metabolic factors, multivariate logistic regression showed that participants in Q4 had a lower OR of NPDR than those in Q1 (OR 0.443, 95% confidence interval 0.300-0.654, P < 0.001 for men; OR 0.428, 95% confidence interval 0.283-0.646, P < 0.001 for women).

Conclusions: Low serum PTH levels were significantly associated with complications of NPDR in inpatients. Its causality remains to be further studied.
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http://dx.doi.org/10.1111/jdi.13456DOI Listing
November 2020

Association between gastroesophageal reflux disease and depression disorder: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Oct;99(43):e22696

Department of Gastroenterology, The First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang, Hebei, P.R. China.

Background: This study will systematically synthesize the evidence on the potential association between gastroesophageal reflux disease (GERD) and depression disorder (DD).

Methods: We will search the following electronic bibliographic databases: PubMed/MEDLINE, Embase, Cochrane Library, Web of Science, the Chinese Bio Medical Literature Database, China National Knowledge Infrastructure (CNKI), the China Science and Technology Journal database (VIP) and Wanfang Data. In addition, ongoing trials will be retrieved from the WHO ICTRP Search Portal, the Chinese Clinical Trial Register and The Clinical Trials Register. Articles related to gastroesophageal reflux disease and depression will be searched. And language and time will be unlimited.

Results: The study will afford additional insight into the investigation the association between GERD and DD.

Conclusions: The results of this study will provide helpful evidence to explore the association between GERD and DD.

Registration Number: INPLASY202090026.
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http://dx.doi.org/10.1097/MD.0000000000022696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581124PMC
October 2020

Surface functionalized red fluorescent dual-metallic Au/Ag nanoclusters for endoplasmic reticulum imaging.

Mikrochim Acta 2020 Oct 14;187(11):606. Epub 2020 Oct 14.

College of Biological, Chemical Science and Engineering, Jiaxing University, Jiaxing, 314001, China.

An efficient method is reported to prepare endoplasmic reticulum-targetable dual-metallic gold-silver nanoclusters, denoted as ER-Au/Ag nanoclusters (NCs), by virtue of a rationally designed molecular ligand. The prepared ER-Au/Ag NCs possesses red-emitting fluorescence with a strong emission at 622 nm and a high fluorescence quantum yield of 5.1%, which could avoid the influence of biological auto-fluorescence. Further investigation results showed that ER-Au/Ag NCs exhibited superior photostability, minimal cytotoxicity, and ER-targeting capability. Enabled by these meritorious features, ER-Au/Ag NCs have been successfully employed for long-term bioimaging of ER in living cells.Graphical abstract A sensitive non-enzymatic fluorescent glucose probe-based ZnO nanorod decorated with Au nanoparticles.
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http://dx.doi.org/10.1007/s00604-020-04585-0DOI Listing
October 2020

Hierarchically porous carbon derived from potassium-citrate-loaded poplar catkin for high performance supercapacitors.

J Colloid Interface Sci 2021 Jan 27;582(Pt B):940-949. Epub 2020 Aug 27.

Department of Environmental Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address:

A simple one-step preparation of biomass derived carbon materials with hierarchical pore structure for supercapacitor application is proposed. Briefly, potassium citrate is loaded onto poplar catkin, a forestry and agricultural residue, for carbonization at different temperature (750-900 ℃). With the confined effect of poplar catkin and pore-forming role of potassium compounds, interconnected carbon networks combining of macropores, small mesopores and micropores are obtained. The product carbonized at 850 ℃ (S-850) processes large surface area of 2186 m/g with two main micropore ranges distributed in 0.5-0.7 nm and 0.7-1.5 nm, and the sample of S-900 processes relatively high electrical conductivity because of the high degree of graphitization. The electrodes based on these carbon materials show main electrical double-layer capacitors with small part of pseudo-capacitors due to O-doping. The S-850 sample displays superior specific capacity at low charge-discharge current density while the electrode based on S-900 shows high specific capacity under high current density. The symmetrical devices based on S-850 give a superb stability and high energy and power densities in alkaline electrolyte. Within a voltage window of 1.4 V, the device can deliver a 13.3 Wh/kg energy density at a power density of 720 W/kg and maintain 7.8 Wh/kg at 14040 W/kg.
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http://dx.doi.org/10.1016/j.jcis.2020.08.088DOI Listing
January 2021

Facile synthesis of anionic porous organic polymer for ethylene purification.

J Colloid Interface Sci 2021 Jan 2;582(Pt B):631-637. Epub 2020 Sep 2.

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China.

The removal of acetylene from ethylene is of vital significance in the petroleum and chemical industry, the presence of trace acetylene impurities in ethylene polymerization process could lead to the interruption of ethylene polymerization. Herein, we construct a new anionic porous organic polymer using potassium tetraphenylborate via Friedel-Crafts alkylation reaction under mild conditions. The resulting material, APOP, possesses good thermal stability and a decent BET surface area, as exemplified by thermogravimetric analysis measurement and nitrogen gas sorption experiment. Acetylene and ethylene adsorption isotherms reveal that APOP has a higher adsorption capacity of acetylene than that of ethylene under same conditions. Ideal adsorbed solution theory calculations and breakthrough experiments both demonstrate that APOP is capable of selective adsorption of acetylene over ethylene. To the best of our knowledge, APOP represents the first anionic porous organic polymer material capable of selective adsorption of acetylene over ethylene, and the exploration of APOP may provide a new way for these key gas separations using ionic porous organic polymer materials.
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http://dx.doi.org/10.1016/j.jcis.2020.08.104DOI Listing
January 2021

Metastatic large cell neuroendocrine lung cancer to the foramen magnum: A case report.

Medicine (Baltimore) 2020 Aug;99(33):e21628

Department of Neurosurgery, Xijing Hospital, Air Force Medical University, Xi 'an Shaanxi, China.

Rationable: Large cell neuroendocrine carcinoma of the lung is rare, especially in the area of the foramen magnum. No previous studies have reported metastatic large cell neuroendocrine lung cancer to the foramen magnum. This paper will be the first time to report this special case.

Patient Concerns: A case of a 37-year-old woman presented with headache that had developed 20 days previously. Imaging examination revealed a circular abnormal signal at the posterior margin of the foramen magnum.

Diagnoses: The patient we report was diagnosed with a metastatic intracranial tumor.

Interventions: The patient underwent occipital craniotomy. Pathological results showed metastatic neuroendocrine carcinoma of the brain. Whole body PET-CT examination showed that fusiform soft tissue shadows could be seen near the hilum of the lower lobe of the left lung.

Outcomes: The final bronchoscopy pathological results showed the large cell neuroendocrine carcinoma of the lung. The patient underwent further chemotherapy and radiotherapy in the oncology department.

Lessons: Diagnosis and treatment of large cell neuroendocrine carcinoma of the lung are difficult. The prognosis is poorer, and effective treatment is urgently needed.
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http://dx.doi.org/10.1097/MD.0000000000021628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437775PMC
August 2020

A near-infrared fluorescent probe for hydrogen polysulfides detection with a large Stokes shift.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Dec 1;242:118755. Epub 2020 Aug 1.

College of Chemistry & Chemical Engineering, Central South University, Changsha 410083, PR China; Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, Changsha 410083, PR China. Electronic address:

Due to the crucial biological roles of hydrogen polysulfides (HS) in living systems, the selective determination of HS is essential. In this work, we reported a turn-on fluorescent probe, JSI-Sn, for HS with high sensitivity and good selectivity. Probe JSI-Sn displayed a near-infrared emission (λ = 701 nm) and a large Stokes shift (123 nm) in the presence of HS in solution. Using probe JSI-Sn as an indispensable tool, the monitoring of intracellular HS in living cells and zebrafish were realized.
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http://dx.doi.org/10.1016/j.saa.2020.118755DOI Listing
December 2020

A comparison of the efficacy and safety of complementary and alternative therapies for gastroesophageal reflux disease: A protocol for network meta-analysis.

Medicine (Baltimore) 2020 Jul;99(30):e21318

Hebei Province Hospital of Chinese Medicine, Shijiazhuang City, Hebei, China.

Background: Gastroesophageal reflux disease (GERD) is one of the most common gastrointestinal diseases in the world and is showing increasing prevalence in some countries. The disease has a chronic course that leads to a significant decline in the quality of life of patients and is associated with a high economic burden worldwide. And complementary and alternative medicine is used to treat the disease. Over the past few decades, a number of randomized controlled trials and systematic evaluations have been conducted to evaluate the effectiveness and safety of different types of complementary and alternative medicine methods, so there is an urgent need to summarize and further evaluate these studies.

Methods: We will search the following sources without restrictions for date, language, or publication status: PubMed, Cochrane Central Register of Controlled Trials (CENTRAL) Cochrane Library, and EMBASE, China National Knowledge Infrastructure, Chinese Bio-medicine Database, VIP Chinese Periodical Database, Wan Fang Database. We will apply a combination of Medical Subject Heading and free-text terms incorporating database-specific controlled vocabularies and text words to implement search strategies. We will also search the ongoing trials registered in the World Health Organization's International Clinical Trials Registry Platform. Besides, the previous relevant reviews conducted on complementary and alternative therapies for GERD and reference lists of included studies will also be searched.

Results: This study will provide a reliable basis for the treatment of GERD with complementary and alternative therapies.

Conclusions: The findings will be an available reference to evaluate the efficacy and safety of complementary and alternative therapies on GERD and may provide decision-making reference on which method to choose for clinicians.

Prospero Registration Number: PROSPERO CRD42020169332.
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http://dx.doi.org/10.1097/MD.0000000000021318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387018PMC
July 2020

Identification of compound mutations of SLC12A3 gene in a Chinese pedigree with Gitelman syndrome exhibiting Bartter syndrome-liked phenotypes.

BMC Nephrol 2020 08 5;21(1):328. Epub 2020 Aug 5.

Department of Endocrinology and Metabolism, the Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.

Background: Gitelman syndrome is a rare salt-losing renal tubular disorder associated with mutation of SLC12A3 gene, which encodes the Na-Cl co-transporter (NCCT). Gitelman syndrome is characterized by hypokalemia, metabolic alkalosis, hypomagnesemia, hypocalciuria, and renin-angiotensin-aldosterone system (RAAS) activation. Different SLC12A3 variants may lead to phenotypic variability and severity.

Methods: In this study, we reported the clinical features and genetic analysis of a Chinese pedigree diagnosed with Gitelman syndrome.

Results: The proband exhibited hypokalaemia, hypomagnesemia, metabolic alkalosis, but hypercalciuria and kidney stone formation. The increased urinary calcium excretion made it confused to Bartter syndrome. The persistent renal potassium wasting resulted in renal tubular lesions, and might affect urinary calcium reabsorption and excretion. Genetic analysis revealed mutations of SLC12A3 gene with c.433C > T (p.Arg145Cys), c.1077C > G (p.Asn359Lys), and c.1666C > T (p.Pro556Ser). Potential alterations of structure and function of NCCT protein due to those genetic variations of SLC12A3 are predicted. Interestingly, one sibling of the proband carried the same mutant sites and exhibited similar clinical features with milder phenotypes of hypokalemia and hypomagnesemia, but hypocalciuria rather than hypercalciuria. Family members with at least one wild type copy of SLC12A3 had normal biochemistry. With administration of spironolactone, potassium chloride and magnesium supplement, the serum potassium and magnesium were maintained within normal ranges.

Conclusions: In this study, we identified compound mutations of SLC12A3 associated with varieties of clinical features. Further efforts are needed to investigate the diversity in clinical manifestations of Gitelman syndrome and its correlation with specific SLC12A3 mutations.
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http://dx.doi.org/10.1186/s12882-020-01996-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409507PMC
August 2020

Mitochondrial DNA: A New Predictor of Diabetic Kidney Disease.

Int J Endocrinol 2020 15;2020:3650937. Epub 2020 Jul 15.

Department of Endocrinology, The Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, China.

Diabetic kidney disease (DKD) is a common cause of end-stage renal disease, and diagnosis and treatment in time can help delay its progress. At present, there are more and more studies on the pathogenesis of DKD; mitochondrial dysfunction plays an important role in DKD. The occurrence and development of DKD is closely related to epigenetic changes and the interaction between mtDNA, ROS, inflammatory factors, and endothelial damage, which continuously aggravates kidney. The change of mtDNA is both the cause of DKD and the result of DKD. It is of great significance to incorporate the change of mtDNA into the monitoring of patients with diabetes. Existing evidence indicates that changes in mtDNA copy number in blood and urine reflect mitochondrial dysfunction and the severity of DKD. However, large-scale, long-term follow-up clinical trials are still needed to determine the threshold range. By the time, mitochondrial-targeted antioxidants will become a new method for the treatment of DKD and other diabetic complications; mtDNA also can be a therapeutic target for them.
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http://dx.doi.org/10.1155/2020/3650937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378596PMC
July 2020

Comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019: A systematic review and meta-analysis.

Int J Infect Dis 2020 Oct 25;99:47-56. Epub 2020 Jul 25.

Department of Endocrinology, Affiliated Hospital of Medical College Qingdao University, Qingdao, China. Electronic address:

Objectives: Existing findings regarding the relationship between comorbidities and the severity of coronavirus disease 2019 (COVID-19) are inconsistent and insufficient. The aim of this study was to evaluate the association between different comorbidities and the severity of COVID-19.

Methods: The PubMed, Embase, and Cochrane Library databases were searched to identify studies reporting the rates of comorbidities in COVID-19 patients with severe/fatal outcomes. Subgroup analyses were conducted according to disease severity and the country of residence. Odds ratios (OR) with 95% confidence intervals (CI) were pooled using random-effects models.

Results: A total of 34 eligible studies were identified. In patients with severe/fatal COVID-19, the most prevalent chronic comorbidities were obesity (42%, 95% CI 34-49%) and hypertension (40%, 95% CI 35-45%), followed by diabetes (17%, 95% CI 15-20%), cardiovascular disease (13%, 95% CI 11-15%), respiratory disease (8%, 95% CI 6-10%), cerebrovascular disease (6%, 95% CI 4-8%), malignancy (4%, 95% CI 3-6%), kidney disease (3%, 95% CI 2-4%), and liver disease (2%, 95% CI 1-3%). In order of the prediction, the pooled ORs of the comorbidities in patients with severe or fatal COVID-19 when compared to patients with non-severe/fatal COVID-19 were as follows: chronic respiratory disease, OR 3.56 (95% CI 2.87-4.41); hypertension, OR 3.17 (95% CI 2.46-4.08); cardiovascular disease, OR 3.13 (95% CI 2.65-3.70); kidney disease, OR 3.02 (95% CI 2.23-4.08); cerebrovascular disease, OR 2.74 (95% CI 1.59-4.74); malignancy, OR 2.73 (95% CI 1.73-4.21); diabetes, OR 2.63 (95% CI 2.08-3.33); and obesity, OR 1.72 (95% CI 1.04-2.85). No correlation was observed between liver disease and COVID-19 aggravation (OR 1.54, 95% CI 0.95-2.49).

Conclusions: Chronic comorbidities, including obesity, hypertension, diabetes, cardiovascular disease, cerebrovascular disease, respiratory disease, kidney disease, and malignancy are clinical risk factors for a severe or fatal outcome associated with COVID-19, with obesity being the most prevalent and respiratory disease being the most strongly predictive. Knowledge of these risk factors could help clinicians better identify and manage the high-risk populations.
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http://dx.doi.org/10.1016/j.ijid.2020.07.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381888PMC
October 2020

Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats.

Geroscience 2020 10 21;42(5):1387-1410. Epub 2020 Jul 21.

Department of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.

Diabetes mellitus (DM) is a leading risk factor for aging-related dementia; however, the underlying mechanisms are not well understood. The present study, utilizing a non-obese T2DN diabetic model, demonstrates that the myogenic response of the middle cerebral artery (MCA) and parenchymal arteriole (PA) and autoregulation of cerebral blood flow (CBF) in the surface and deep cortex were impaired at both young and old ages. The impaired CBF autoregulation was more severe in old than young DM rats, and in the deep than the surface cortex. The myogenic tone of the MCA was enhanced at perfusion pressure in the range of 40-100 mmHg in young DM rats but was reduced at 140-180 mmHg in old DM rats. No change of the myogenic tone of the PA was observed in young DM rats, whereas it was significantly reduced at 30-60 mmHg in old DM rats. Old DM rats had enhanced blood-brain barrier (BBB) leakage and neurodegeneration, reduced vascular density, tight junction, and pericyte coverage on cerebral capillaries in the CA3 region in the hippocampus. Additionally, DM rats displayed impaired functional hyperemia and spatial learning and short- and long-term memory at both young and old ages. Old DM rats had impaired non-spatial short-term memory. These results revealed that impaired CBF autoregulation and enhanced BBB leakage plays an essential role in the pathogenesis of age- and diabetes-related dementia. These findings will lay the foundations for the discovery of anti-diabetic therapies targeting restoring CBF autoregulation to prevent the onset and progression of dementia in elderly DM.
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http://dx.doi.org/10.1007/s11357-020-00233-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525432PMC
October 2020

The efficacy and safety of fecal microbiota transplantation in the treatment of systemic sclerosis: A protocol for systematic review and meta analysis.

Medicine (Baltimore) 2020 Jul;99(28):e21267

Hebei Province Hospital of Chinese Medicine, Shijiazhuang City, Hebei.

Background: Systemic sclerosis (SSc) is 1 of the most complex systemic autoimmune diseases.Accumulating evidence suggests that gut microbiota affect the development and function of the immune system and may play a role in the pathogenesis of autoimmune diseases. This new paradigm raises the possibility that many diseases result, at least partially, from microbiota-related dysfunction. This understanding invites the investigation of fecal microbiota transplantation (FMT) in the treatment of SSc. However, no study has specifically and systematically investigated the efficacy and safety of FMT in the treatment of SSc. Thus, this study will systematically and comprehensively appraise the efficacy and safety of FMT in the treatment of SSc.

Methods: We will search the following sources without restrictions for date, language, or publication status: PubMed, Web of Science,Cochrane Central Register of Controlled Trials (CENTRAL) Cochrane Library, EMBASE and China National Knowledge Infrastructure. We will apply a combination of Medical Subject Heading (MeSH) and free-text terms incorporating database-specific controlled vocabularies and text words to implement search strategies. We will also search the ongoing trials registered in the World Health Organization's International Clinical Trials Registry Platform. Besides, the previous relevant reviews conducted on FMT for SSc and reference lists of included studies will also be searched.

Results: This study will provide a reliable basis for the treatment of SSc with FMT.

Conclusions: The findings will be an available reference to evaluate the efficacy and safety of FMT in the treatment of SSc.

Registration Number: INPLASY202060019.
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http://dx.doi.org/10.1097/MD.0000000000021267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360200PMC
July 2020

Obesity and diabetes as high-risk factors for severe coronavirus disease 2019 (Covid-19).

Diabetes Metab Res Rev 2021 02 20;37(2):e3377. Epub 2020 Jul 20.

Department of Endocrinology, Affiliated Hospital of Medical College Qingdao University, Qingdao, China.

The outbreak of the coronavirus disease 2019 (Covid-19) has become an evolving worldwide health crisis. With the rising prevalence of obesity and diabetes has come an increasing awareness of their impacts on infectious diseases, including increased risk for various infections, post-infection complications and mortality from critical infections. Although epidemiological and clinical characteristics of Covid-19 have been constantly reported, no article has systematically illustrated the role of obesity and diabetes in Covid-19, or how Covid-19 affects obesity and diabetes, or special treatment in these at-risk populations. Here, we present a synthesis of the recent advances in our understanding of the relationships between obesity, diabetes and Covid-19 along with the underlying mechanisms, and provide special treatment guidance for these at-risk populations.
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http://dx.doi.org/10.1002/dmrr.3377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7361201PMC
February 2021

Insulin delivery with a needle-free insulin injector versus a conventional insulin pen in Chinese patients with type 2 diabetes mellitus: A 16-week, multicenter, randomized clinical trial (the FREE study).

EClinicalMedicine 2020 Jun 4;23:100368. Epub 2020 Jun 4.

Department of Endocrinology, the First Affiliated Hospital of China Medical University, Shenyang, China.

Background: Insulin therapy is poorly accepted by patients with type 2 diabetes mellitus (T2DM). A needle-free insulin injector has been developed for patients who fear injections or are reluctant to initiate insulin therapy when it is clearly indicated. The objective of this trial was to evaluate the glucose-lowering effect, tolerability, patient satisfaction and compliance with insulin treatment via a needle-free insulin injector (NFII) compared with insulin treatment via a conventional insulin pen (CIP) in patients with T2DM.

Methods: A total of 427 patients with T2DM were enrolled in a prospective, multicenter, randomized, open-label study, and were randomly assigned 1:1 to receive 16 weeks' treatment with basal insulin or premixed insulin administered either by a NFII or CIP.

Trial Registration: ClinicalTrials.gov (NCT03243903).

Findings: In the 412 patients who completed the study, the adjusted mean reduction of HbA1c from baseline at week 16 in the NFII group was 0.55% (95% CI -0.71, -0.39), which was non-inferior and statistically superior to the HbA1c reduction in the CIP group (0.26%, 95% CI -0.42, -0.11). Patients in the NFII group showed significantly higher treatment satisfaction scores than those in the CIP group (mean scores, 8.17 ± 1.78 vs. 7.21 ± 2.22, respectively; <0.0001). The occurrence of hypoglycemia was similar in the two groups, and the NFII group showed reduced incidences of skin scratches, indurations and lower VAS pain scores.

Interpretation: Insulin therapy through needle-free injector showed a non-inferior glycemic-lowering effect and a significantly enhanced level of patient satisfaction with insulin treatment compared with conventional insulin therapy through needle injections. In addition, the needle-free injector also had a better safety profile.

Funding: This study were funded by Beijing QS Medical Technology Co., Ltd, as well as The Major Chronic Non-communicable Disease Prevention and Control Research.
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http://dx.doi.org/10.1016/j.eclinm.2020.100368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283138PMC
June 2020

Dramatic enhancement of photocatalytic H evolution over hydrolyzed MOF-5 coupled ZnCdS heterojunction.

J Colloid Interface Sci 2020 Oct 23;577:233-241. Epub 2020 May 23.

College of Biological Chemical Science and Engineering, Jiaxing University, Jiaxing 314001, China. Electronic address:

MOF-5 has been criticized for its poor water stability, which results in complete damage of its traditional functionality. Therefore, there are very few researches about the further application of hydrolyzed MOF-5 (h-M). However, in this work, the h-M can function as both superior support and semiconductor for photocatalytic reaction after a water-based process. Herein, a rational design of [email protected] ([email protected]) heterojunction photocatalyst has been synthesized via a hydrothermal method with different mass ratio of ZCS. As demonstrated in the results of SEM and TEM, during the hydrothermal process, MOF-5 exfoliated into two-dimensional small sheets and ZCS nanoparticles embedded into h-M frameworks, which is in favor for the dispersion of ZCS and better interface connection, thus further boosts the migration of photogenerated charge carriers and protect the photocorrosion of ZCS, ultimately improves the photocatalytic hydrogen production. Optimal ZCS content of 10 wt% exhibited a significantly enhanced visible light photocatalytic hydrogen production efficiency of 15.08 mmol h g, which far surpassed bare ZCS at 7.62 times. Furthermore, the [email protected] showed outstanding stability during photocatalytic hydrogen production over a number of cycles.
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http://dx.doi.org/10.1016/j.jcis.2020.05.023DOI Listing
October 2020

Blood glucose fluctuations detected by continuous glucose monitoring system in gout patients with normal glucose tolerance and the effect of urate-lowering therapy.

Int J Rheum Dis 2020 Aug 1;23(9):1145-1151. Epub 2020 Jun 1.

Department of Endocrinology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Aim: The aim of this study was to investigate whether there are blood glucose fluctuations in gout patients with hyperuricemia and normal glucose tolerance, and the effect of urate-lowering therapy on blood glucose fluctuations.

Methods: Thirty patients with newly diagnosed gout, hyperuricemia and normal glucose tolerance were enrolled in our study. Continuous glucose monitoring system (CGMS) was used to detect the blood glucose fluctuations of these gout patients. Changes in blood glucose fluctuations after allopurinol therapy were also evaluated.

Results: Compared with the reference values of blood glucose fluctuation parameters in China, gout patients had greater glycemic fluctuations including higher mean amplitude of glucose excursions (MAGE) (4.65 vs 1.94 mmol/L, P < .001), higher largest amplitude of blood glucose excursions (LAGE) (4.99 vs 3.72 mmol/L, P < .001) and higher standard deviations of blood glucose (SDBG) (1.36 vs 0.79 mmol/L, P < .001). MAGE was significantly correlated with uric acid (β = .007, P = .024) and HOMA-insulin resistance (IR) (β = .508, P = .03). Allopurinol treatment significantly reduced MAGE (4.16 vs 4.65 mmol/L, P < .001), SDBG (0.99 vs 1.36 mmol/L, P < .001) and HOMA-IR (2.26 vs 3.01, P < .001) in gout patients.

Conclusion: Blood glucose fluctuation increased even in the stage of normal glucose tolerance among gout patients. Blood glucose fluctuations in gout patients were associated with the level of serum uric acid and allopurinol could decrease blood glucose fluctuation as well as IR.
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http://dx.doi.org/10.1111/1756-185X.13862DOI Listing
August 2020

Elevated circulating luteinizing hormone levels are associated with diabetic macroalbuminuria in Chinese men and postmenopausal women: A cross-sectional study.

J Diabetes 2020 Nov 10;12(11):819-833. Epub 2020 Jul 10.

Department of Endocrinology, Affiliated Hospital of Medical College Qingdao University, Qingdao, China.

Background: Associations between sex hormones and diabetic vascular complications have recently been studied, but the role luteinizing hormone (LH) plays in diabetic kidney disease (DKD) remains uncertain. We aimed to investigate the relationship of LH and DKD in Chinese men and postmenopausal women with type 2 diabetes mellitus (T2DM).

Methods: Data were collected from 1775 T2DM men and postmenopausal women in hospital. The odds ratios (OR) and corresponding 95% confidence intervals (CI) in relation to LH quartiles were obtained by multiple logistic regression analysis.

Results: LH levels were significantly higher in patients with macroalbuminuria than in those with microalbuminuria, but were not higher in patients with microalbuminuria than in those with normoalbuminuria. Consistently, LH in those with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m were significantly higher than in those with eGFR≥60 mL/min/1.73m . The prevalence of macroalbuminuria was obviously increased for subjects of the fourth quartile of LH vs the first to third quartile (20.4% vs 6.2%, 8.0%, 12.2% in men; 25.3% vs 5.5%, 3.8%, 9.3% in postmenopausal women). Multivariate logistic regression demonstrated that subjects within the highest quartile of LH had higher odds of macroalbuminuria than those within the lowest quartile (OR 4.00, 95% CI, 1.87-8.55 for men; OR 9.62, 95% CI, 3.42-27.08 for postmenopausal women), independent of age, diabetes duration, or other metabolic factors. The area under the curve for detecting macroalbuminuria based on LH was 0.662 for men, and 0.767 for postmenopausal women.

Conclusion: High LH levels are positively associated with established DKD among Chinese men and postmenopausal women. Elevated LH may be a promising clinical factor for identifying established DKD.
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http://dx.doi.org/10.1111/1753-0407.13073DOI Listing
November 2020