Publications by authors named "Yang Zheng"

1,351 Publications

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[Study of the Relationship between Oral Diseases and Depression Symptoms in Middle-Aged and Older Adult Populations in China-A Retrospective Study Based on CHARLS Data].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Nov;52(6):987-991

State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Objective: To study the relationship between oral disease and depressive symptoms in middle-aged and older adult populations in China.

Methods: The data from the China Health and Retirement Longitudinal Study (CHARLS) done between 2013 and 2015 were analyzed. A total of 3828 middle-aged and older adults showing no depressive symptoms in an assessment with the 10-item Centre for Epidemiological Studies Depression Scale (CES-D-10) were selected as the subjects of observation, and oral disease was taken as the dependent variable. Changes in depressive symptoms in the population were tracked in 2015, and the Cox proportional hazards model was used to estimate the relationship between oral diseases and depressive symptoms.

Results: The detection rate of depressive symptoms was 29.3% in middle-aged and older adults with oral diseases, and that of middle-aged and older adults without oral diseases was 20.4%, the difference being statistically significant ( <0.001). After controlling for confounding factors, Cox proportional hazards model analysis found an association between oral diseases and depressive symptoms (hazard ratio [ ]=0.683, 95% confidence interval [ ]: 0.583-0.800). It was more likely for middle-aged and older women ( =0.708, 95% : 0.573-0.874) with oral diseases to develop depressive symptoms than men ( =0.644, 95% : 0.506-0.819) did ( <0.05).

Conclusion: Oral diseases in the middle-aged and older adult populations tended to lead to depressive symptoms, and women showed higher rate than men did. Prevention and control measures should be taken actively in the course of oral disease treatment to promote mental health of middle-aged and older adults.
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http://dx.doi.org/10.12182/20211160106DOI Listing
November 2021

Novel Minimally-Invasive Triple Pelvic Osteotomy: JiShuiTan Minimally-Invasive Approach.

J Pediatr Orthop 2021 Nov 25. Epub 2021 Nov 25.

Department of Pediatric Orthopaedics, BeiJing JiShui Tan Hospital, Beijing, China.

Purpose: Triple pelvic osteotomy (TPO) is often performed to improve femoral head coverage, correct deformity, and stabilize the hip joint in a variety of pediatric orthopaedic conditions. After the TPO was first reported, many modifications were developed to simplify or improve the procedure, however, because of the specific anatomy with several critical nerves and vessels passing through the approaches, extensive exposure and prolonged intraoperative fluoroscopy are often required for TPO. This report introduces a novel, minimally-invasive surgical approach that minimizes the time of intraoperative fluoroscopy and size of the surgical incision, and reviews our experience.

Methods: A total of 48 hips in 43 patients with a mean age of 8.3±1.7 years (range: 6.0 to 12.2 y) were included in this study. Of these, 21 patients (22 hips) had Legg-Calvé-Perthes disease (LCPD) and 22 patients (26 hips) had developmental dysplasia of the hip (DDH). The TPOs were performed using the novel, minimally-invasive TPO approach, with a mean postoperative follow-up of 38 months (range: 24 to 54 mo) in the DDH group and 44 months (range: 23 to 58 mo) in the LCPD group. The acetabular index (AI), femoral head migration rate (MP), center edge angle (CEA) and the Severin and Stulberg classification systems were used to evaluate the preoperative and postoperative results. SPSS software was used to analyze the data.

Results: The AI decreased from 33.8 degrees±9.2 to 2.9 degrees±10.1, the lateral CEA increased from -10.8 degrees±23.8 to 34.1 degrees±9.9, and the femoral head MP decreased from 64.0%±19.8% to 1.1%±2.6% in the DDH group at last follow-up, indicating significant improvement. The AI decreased from 20.8 degrees±4.7 to -1.3 degrees±7.3, the lateral CEA increased from 6.8 degrees±11.5 to 42.3 degrees±6.4, and the femoral head MP decreased from 42.2%±13.0% to 1.3%±3.3% in the LCPD group at last follow-up, also indicating significant improvement.

Conclusion: This approach can simplify the TPO, making the complex operation safer, more effective, and capable of achieving satisfactory correction.
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http://dx.doi.org/10.1097/BPO.0000000000002019DOI Listing
November 2021

A Novel Deoxynivalenol-Activated Wheat Gene Encodes an Antifungal Peptide with Deoxynivalenol Affinity and Protects Plants against Pathogens and Mycotoxins.

J Fungi (Basel) 2021 Nov 6;7(11). Epub 2021 Nov 6.

Molecular Biotechnology Laboratory of Triticeae Crops, Huazhong Agricultural University, Wuhan 430070, China.

Deoxynivalenol (DON) is one of the most widespread trichothecene mycotoxins in contaminated cereal products. DON plays a vital role in the pathogenesis of , but the molecular mechanisms of DON underlying -wheat interactions are not yet well understood. In this study, a novel wheat ADP-ribosylation factor-like protein 6-interacting protein 4 gene, was identified from DON-treated wheat suspension cells by suppression subtractive hybridization (SSH). The qRT-PCR result suggested that expression is specifically activated by DON in both the intermediate susceptible wheat cultivar Zhengmai9023 and the resistant cultivar Sumai3. The transient expression results of the TaARL6IP4::GFP fusion protein indicate that encodes a plasma membrane and nucleus-localized protein. Multiple sequence alignment using microscale thermophoresis showed that TaARL6IP4 comprises a conserved DON binding motif, HXXXG, and exhibits DON affinity with a dissociation constant () of 91 ± 2.6 µM. Moreover, TaARL6IP4 exhibited antifungal activity with IC values of 22 ± 1.5 µM and 25 ± 2.6 µM against and , respectively. Furthermore, TaArl6ip4 interacted with the plasma membrane of spores, resulting in membrane disruption and the leakage of cytoplasmic materials. The heterologous over-expression of conferred greater DON tolerance and resistance in Finally, we describe a novel DON-induced wheat gene, , exhibiting antifungal function and DON affinity that may play a key role in wheat interactions.
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http://dx.doi.org/10.3390/jof7110941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618893PMC
November 2021

FN3 Domain Displaying Double Epitopes: A Cost-Effective Strategy for Producing Substitute Antigens.

Front Mol Biosci 2021 4;8:742617. Epub 2021 Nov 4.

Medical College, Dalian University, Dalian, China.

Construction of substitute antigens based on alternative scaffold proteins is a promising strategy in bioassay technology. In this study, we proposed a strategy for constructing substitute antigens derived from 10th human fibronectin type III (FN3) using two peptide epitopes of terminal pro-brain natriuretic peptide (NT-proBNP) as an example. The base sequences encoding the two antigenic epitopes of NT-proBNP were recombined into the FG loop region and the C-terminus of FN3, fused by 4 GS or polyN linker. The fusion proteins (named FN3-epitopes-4GS and FN3-epitopes-polyN, respectively) were expressed and purified cost-effectively using an expression system. The immunoreactivity of recombinant substitutes was preliminarily confirmed by western blot analysis using epitope-specific antibodies. The sandwich enzyme-linked immunosorbent assay demonstrated that either FN3-epitopes-polyN or FN3-epitopes-4GS was highly sensitive, and FN3-epitopes-polyN exhibited better kinetics to specific antibodies than FN3-epitopes-4GS, showing a linear dose-response relationship in the concentration range of 0.06-12.85 ng/ml, which suggest that the polyN linker was more suitable for constructing the FN3-based substitute antigens compared to the 4 GS linker. Furthermore, the serum stability test and differential scanning calorimetry analysis showed that the recombinant FN3-epitopes-polyN maintained the original stability of FN3. Therefore, it was confirmed that FN3 could be engineered to construct a stable biomacromolecular substitute for displaying double epitopes of antigen proteins, such as NT-proBNP. In summary, a cost-effective strategy to produce NT-proBNP substitute antigens with good immunoreactivity and physicochemical stability was established in this work, which may provide potential uses for the production of other substitute antigens in the future.
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http://dx.doi.org/10.3389/fmolb.2021.742617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607273PMC
November 2021

Influence of abstinence on automatic detection bias to gaming cues in individuals with Internet gaming disorder: Evidence from visual mismatch negativity.

Psychophysiology 2021 Nov 24:e13973. Epub 2021 Nov 24.

State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.

Internet gaming disorder (IGD) has been classified by the DSM-5 as a condition for further study, and many studies have shown that the occurrence and maintenance of IGD and the automatic detection bias to gaming cues of individuals with IGD may be significantly related. However, whether abstinence, a common intervention method in behavioral addiction, can adjust the automatic detection bias in individuals with IGD and its underlying neural mechanisms is unclear. In this study, we investigated the effects of 7 days of abstinence from gaming on automatic detection bias, negative affect and craving in individuals with IGD with event-related potential technology. A total of 50 IGD subjects were recruited in this study and randomly divided into abstinence and control groups. Visual mismatch negativity (vMMN) was induced using a standard-deviant reversed oddball paradigm, and differences in automatic detection bias, negative affect, and craving between the two groups were recorded and compared at baseline, day 3, and day 7. The results showed that compared with baseline, vMMN, negative affect and craving were significantly enhanced on day 3 and significantly diminished on day 7 in the abstinence group but not in the control group, and the changes in vMMN were significantly correlated with changes in negative affect and craving in both groups. This study demonstrates that abstinence can restore automatic detection bias in individuals with IGD and that abstinence has to last for 7 days to have a significant effect, while recovery may be related to the negative affect and craving.
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http://dx.doi.org/10.1111/psyp.13973DOI Listing
November 2021

[Comparative study of two high-efficiency methods for purifying spermatogonial stem cells].

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2021 Sep;37(5):571-576

Laboratory of Psychosomatic Medicine, Inner Mongolia Medical University, Hohhot 010110, China.

To compare the advantages and disadvantages of the differential attachment method and immunomagnetic bead method for purification of mouse spermatogonial stem cells (mSSCs). Ten male C57BL/6 mice aged 12~15 days were selected and sacrificed by cervical dislocation. Testes were collected and the seminiferous tubule single cell suspension was obtained by enzymatic digestion. mSSCs were purified by using the differential attachment method and immunomagnetic bead method respectively. Then a detailed comparison of the two methods in terms of cell number, separation efficiency, and impact on cell proliferation and growth was conducted. Both of the methods could isolate and purify stem cells from single cell suspension of mouse seminiferous tubules. mSSCs showed typical grape cluster-like clones in vitro culture, which could be continuously cultured and proliferated for over 3 months in vitro. The testes of 10 mice could obtain 3×10±0.4×10 mSSCs (=5) by differential attachment method, cell recovery rate (the number of cells after purification/the number of cells of the single cell suspension of seminiferous tubules) was 1.5%±0.1%; 6×10±0.4×10 mSSCs (= 5) could be obtained by immunomagnetic bead method. The recovery rate was about 3%±0.1%, and the number of stem cells obtained by the immunomagnetic bead method was higher. The stem cells obtained by the differential attachment method were more pure, because the stem cell colonies were preferentially obtained after 5 days of in vitro culture, while the stem cells obtained by the immunomagnetic bead method needed to be cultured for about 10 days before the obvious cell colonies could be observed, but the two types of purification method had no obvious effect on the long-term growth of cells . Both methods can get high quality mSSCs, but both methods have their own advantages and disadvantages. The differential attachment method is more economical and practical than the other, it does not require special equipment, but the stem cell number obtained is relatively lower and the time needed is longer.
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http://dx.doi.org/10.12047/j.cjap.6046.2021.056DOI Listing
September 2021

Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents.

Eur J Med Chem 2021 Nov 12:113987. Epub 2021 Nov 12.

Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.

To discover antifungal compounds with broad-spectrum and stable metabolism, a series of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives was designed and synthesized. Compounds A30-A34 exhibited excellent broad-spectrum antifungal activity against Candida albicans with MIC values in the range of 0.03-0.5 μg/mL, and against Cryptococcus neoformans and Aspergillus fumigatus with MIC values in the range of 0.25-2 μg/mL. In addition, compounds A31 and A33 showed high metabolic stability in human liver microsomes in vitro, with the half-life of 80.5 min and 69.4 min, respectively. Moreover, compounds A31 and A33 showed weak or almost no inhibitory effect on the CYP3A4 and CYP2D6. The pharmacokinetic evaluation in SD rats showed that compound A31 had suitable pharmacokinetic properties and was worthy of further study.
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http://dx.doi.org/10.1016/j.ejmech.2021.113987DOI Listing
November 2021

Antibiotics in mariculture systems: A review of occurrence, environmental behavior, and ecological effects.

Environ Pollut 2021 Nov 17;293:118541. Epub 2021 Nov 17.

Key Laboratory of Marine Environment and Ecology, Ministry of Education, Ocean University of China, Qingdao, 266100, China; College of Environmental Science and Engineering, Ocean University of China, Qingdao, 266100, China. Electronic address:

Antibiotics are widely applied to prevent and treat diseases occurred in mariculture. The often-open nature of mariculture production systems has led to antibiotic residue accumulation in the culturing and adjacent environments, which can adversely affect aquatic ecosystems, and even human. This review summarizes the occurrence, environmental behavior, and ecological effects of antibiotics in mariculture systems based on peer-reviewed papers. Forty-five different antibiotics (categorized into ten groups) have been detected in mariculture systems around the world, which is far greater than the number officially allowed. Indiscriminate use of antibiotics is relatively high among major producing countries in Asia, which highlights the need for stricter enforcement of regulations and policies and effective antibiotic removal methods. Compared with other environmental systems, some environmental characteristics of mariculture systems, such as high salinity and dissolved organic matter (DOM) content, can affect the migration and transformation processes of antibiotics. Residues of antibiotics favor the proliferation of antibiotic resistance genes (ARGs). Antibiotics and ARGs alter microbial communities and biogeochemical cycles, as well as posing threats to marine organisms and human health. This review may provide a valuable summary of the effects of antibiotics on mariculture systems.
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http://dx.doi.org/10.1016/j.envpol.2021.118541DOI Listing
November 2021

Identification of the key genes and immune infiltrating cells determined by sex differences in ischaemic stroke through co-expression network module.

IET Syst Biol 2021 Nov 18. Epub 2021 Nov 18.

Department of Respiratory, The First People's Hospital of Lanzhou City, Lanzhou, Gansu, China.

Stroke is one of the leading causes of patients' death and long-term disability worldwide, and ischaemic stroke (IS) accounts for nearly 80% of all strokes. Differential genes and weighted gene co-expression network analysis (WGCNA) in male and female patients with IS were compared. The authors used cell type identification by estimating relative subsets of RNA transcripts (CIBERSORT) to analyse the distribution pattern of immune subtypes between male and female patients. In this study, 141 up-regulated and 61 down-regulated genes were gathered and distributed into five modules in response to their correlation degree to clinical traits. The criterion for Gene Ontology (GO) term and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway indicated that detailed analysis had the potential to enhance clinical prediction and to identify the gender-related mechanism. After that, the expression levels of hub genes were measured via the quantitative real-time PCR (qRT-PCR) method. Finally, CCL20, ICAM1 and PTGS2 were identified and these may be some promising targets for sex differences in IS. Besides, the hub genes were further verified by rat experiments. Furthermore, these CIBERSORT results showed that T cells CD8 and Monocytes may be the target for the treatment of male and female patients, respectively.
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http://dx.doi.org/10.1049/syb2.12039DOI Listing
November 2021

Efficacy and safety of immunosuppressive therapy in myelin oligodendrocyte glycoprotein antibody-associated disease: a systematic review and meta-analysis.

Ther Adv Neurol Disord 2021 10;14:17562864211054157. Epub 2021 Nov 10.

Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, China.

Background: A considerable number of patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) will experience a relapse, but the effect of maintenance therapies on re-attack rates is currently unknown.

Objective: To investigate the efficacy and safety of immunosuppressive therapy for preventing disease relapses in patients with MOGAD, including rituximab (RTX), mycophenolate mofetil (MMF), and azathioprine (AZA).

Methods: English-language studies published prior to August 31, 2020, were searched in the NCBI (PubMed), ISI Web of Science, and the Cochrane Library databases. Patient characteristics, treatment regimens, outcome measures, and adverse effects were retrieved.

Results: We enrolled 11 studies in the final meta-analysis, including 346 patients with MOGAD. RTX therapy was demonstrated to result in reduced mean annualized relapse rate (ARR) by 1.35 (95% confidence interval (CI): 0.85-1.85) and reduced mean Expanded Disability Status Scale score by 0.80 (95% CI: 0.53-1.08) in patients with MOGAD. MMF therapy was associated with the mean ARR decreasing by 0.83 (95% CI: 0.31-1.35), and AZA was related to the mean ARR decreasing by 1.71 (95% CI: 0.83-2.58). The reported discontinuation rates of RTX, MMF, and AZA therapy due to adverse effects were 3/197 (1.52%), 3/39 (7.69%), and 4/37 (10.81%), respectively.

Conclusion: The study provided evidence to support the efficacy of RTX, MMF, and AZA on the preventive treatment in patients with MOGAD. However, large randomized controlled trials are still needed in the future.
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http://dx.doi.org/10.1177/17562864211054157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591780PMC
November 2021

Isoliquiritigenin attenuates acute renal injury through suppressing oxidative stress, fibrosis and JAK2/STAT3 pathway in streptozotocin-induced diabetic rats.

Bioengineered 2021 Dec;12(2):11188-11200

Department of Critical Care Medicine, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang Province, PR China.

The aim of the current study was to evaluate the protective effects and mechanisms of isoliquiritigenin (ISO) on acute renal injury. CCK-8 assays were applied to assess the effects of ISO at different doses (20, 40, and 80 μg/mL) on oxidative damage in human renal HK-2 cells incubated with high glucose. After the diabetic nephropathy (DN) rat model was established, the model animals were randomly assigned to saline-treated control, three model groups received the 10, 20 and 40 mg/kg ISO, respectively, using the healthy Sprague-Dawley (SD) rats as normal control. The blood biochemical indexes, renal functions, oxidative stress, morphological changes, fibrosis- and JAK2/STAT3-related factors in DN model rats were all assessed. The cellular viability of the renal HK-2 cells with oxidative damages were all markedly ameliorated via the incubation of ISO between 10 and 80 μg/mL compared with negative control. In addition, the significantly down-regulated ROS content and up-regulated expression levels of GSH, SOD2, and GPX1 were all observed in ISO-treated groups. Long-term administration of ISO at different doses in DN rats effectively improved general diabetic characteristics and renal morphology. Furthermore, long-term administration of ISO could ameliorate excessive oxidation stress, down-regulate the expression levels of renal fibrosis- and inflammation-related factors, as well as inhibit the JAK2/STAT3 signaling pathway. In conclusion, ISO at all three dosages could efficiently improve the renal injury induced by STZ via ameliorating renal fibrosis, oxidative stress, and inhibiting JAK2/STAT3 signaling pathways in the DN rats.
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http://dx.doi.org/10.1080/21655979.2021.2006978DOI Listing
December 2021

Leaf Extract Suppresses the Progress of Atherosclerosis in Rats via the FKN/SYK/p38 Signal Pathway.

Evid Based Complement Alternat Med 2021 3;2021:5524226. Epub 2021 Nov 3.

Department of Cardiovascular, The First Hospital of Jilin University, Changchun, China.

To investigate the antiatherosclerotic effects of flavonoids extracted from (AVF) leaves in atherosclerotic rats and the underlying mechanisms, a total of 72 male Wistar rats were randomly divided into six groups: control group, model group, simvastatin group, low-dose AVF group, medium-dose AVF group, and high-dose AVF group. Atherosclerosis in rats was induced with a high-fat diet and an intraperitoneal injection of VD once daily for three contiguous days at a total injection dose of 70 U/kg. At the end of the 13 week, total serum cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) contents were measured. The hematoxylin-eosin (HE) staining was applied to evaluate the morphological changes. The ELISA method was used to detect related inflammatory factors and oxidative stress indicators. The corresponding protein expression and the mRNA level were detected by western blot analysis and reverse transcriptase PCR. HE staining showed that the thoracic aorta wall was thickened, and the aortic subendothelial foam cells and lipid vacuoles were reduced in the medium/high-AVF groups. Similarly, the TC, TG, LDL-C, and malondialdehyde (MDA) levels in the model group were significantly higher, but the HDL-C level and superoxide dismutase (SOD) activity were lower than those of the control group, and these effects were ameliorated by treatment with simvastatin or AVF. ELISA results showed that compared with the control group, the model group C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor- (TNF-) results were significantly increased, and the medium AVF and high AVF could significantly reduce the expression of related inflammatory factors. The AVF inhibited intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin mRNA and related protein expression in the aorta in atherosclerotic rats. Western blot analysis also showed that AVF can significantly reduce the protein expression of fractalkine (FKN), spleen tyrosine kinase (SYK), and p38 mitogen-activated protein kinase (p38) in the rat aorta. We believe that the AVF can effectively reduce blood lipid levels in rats with atherosclerosis and delay atherosclerotic progression by inhibiting excessive inflammatory factors and inhibiting related adhesion factors. The underlying mechanism may be related to the FKN/SYK/p38 signaling pathway activity. Our results contribute to validating the traditional use of the leaf extract in the treatment of atherosclerosis.
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http://dx.doi.org/10.1155/2021/5524226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580673PMC
November 2021

Dynamic Traffic Assignment Model Based on GPS Data and Point of Interest (POI) in Shanghai.

Sensors (Basel) 2021 Nov 4;21(21). Epub 2021 Nov 4.

School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

Dynamic traffic flow, which can facilitate the efficient operation of traffic road networks, is an important prerequisite for the application of reasonable assignment of traffic demands in an urban road network. In order to improve the accuracy of dynamic traffic flow assignment, this paper proposes a dynamic traffic flow assignment model based on GPS trajectory data and the influence of POI. First, this paper explores the impact patterns of POI on regional road network congestion during peak hours through qualitative and quantitative analysis. Then, based on the user equilibrium theory, a dynamic traffic flow assignment model, in which the effect of POI on links is reflected using the link-node impedance function, is proposed. Finally, the accuracy of the model is validated by the GPS trajectory data and origin-destination (OD) traffic data of motor vehicles in Xuhui District, Shanghai, China. The results show that the model can be used to coordinate and optimize the traffic assignment of the regional road network under the influence of POI during peak hours and alleviate the congestion of the road network. The findings can provide a powerful reference for developing scientific and rational traffic assignment decisions and management strategies for urban road network traffic.
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http://dx.doi.org/10.3390/s21217341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587448PMC
November 2021

Recent Progress in Self-Powered Sensors Based on Triboelectric Nanogenerators.

Sensors (Basel) 2021 Oct 27;21(21). Epub 2021 Oct 27.

School of Materials Science and Engineering, Ocean University of China, Qingdao 266100, China.

The emergence of the Internet of Things (IoT) has subverted people's lives, causing the rapid development of sensor technologies. However, traditional sensor energy sources, like batteries, suffer from the pollution problem and the limited lifetime for powering widely implemented electronics or sensors. Therefore, it is essential to obtain self-powered sensors integrated with renewable energy harvesters. The triboelectric nanogenerator (TENG), which can convert the surrounding mechanical energy into electrical energy based on the surface triboelectrification effect, was born of this background. This paper systematically introduces the working principle of the TENG-based self-powered sensor, including the triboelectrification effect, Maxwell's displacement current, and quantitative analysis method. Meanwhile, this paper also reviews the recent application of TENG in different fields and summarizes the future development and current problems of TENG. We believe that there will be a rise of TENG-based self-powered sensors in the future.
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http://dx.doi.org/10.3390/s21217129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587673PMC
October 2021

Smart exosomes with lymph node homing and immune-amplifying capacities for enhanced immunotherapy of metastatic breast cancer.

Mol Ther Nucleic Acids 2021 Dec 19;26:987-996. Epub 2021 Oct 19.

Department of Breast Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi 530021, China.

Tumor-draining lymph nodes (TDLNs) are the primary sites to initiate immune responses against cancer, as well as the origin of metastasis for most breast cancer cases. Reverting the immunosuppression microenvironment in TDLNs is critical to improving the outcome of the malignancy, though still a big technical challenge. In this study, a type of smart exosomes was developed in which the exosome surface was functionally engineered with CD62L (L-selectin, a gene for lymphocyte homing to lymph nodes) and OX40L (CD134L, a gene for effector T cell expansion and regulatory T cell [Treg] inhibition) by forced expression of the genes in the donor cells. Compared with control exosomes, the smart exosomes displayed strong TDLN homing capacity in the 4T1 syngeneic mouse model. Moreover, injection of the smart exosomes activated effector T cells and inhibited Treg induction, thereby amplifying the antitumor immune response and inhibiting tumor development. Together, the engineered smart exosomes provide a novel nanoplatform for TDLN-targeted delivery and cancer immunotherapy.
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http://dx.doi.org/10.1016/j.omtn.2021.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560825PMC
December 2021

Competitive tetrel bond and hydrogen bond in benzaldehyde-CO: characterization rotational spectroscopy.

Phys Chem Chem Phys 2021 Nov 24;23(45):25784-25788. Epub 2021 Nov 24.

School of Chemistry and Chemical Engineering, Chongqing University, Daxuecheng South Rd. 55, 401331, Chongqing, China.

The rotational spectrum of the 1 : 1 benzaldehyde-CO complex has been investigated using pulsed-jet Fourier transform microwave spectroscopy complemented with quantum chemical calculations. Two isomers, both characterized by one C⋯O tetrel bond (n → π* interaction) and one C-H⋯O hydrogen bond (n → σ* interaction), have been observed in the pulsed jet. Competition between the tetrel bond and the hydrogen bond has been disclosed by natural bond orbital analysis: isomer I is characterized by one dominating OC⋯O tetrel bond (12.6 kJ mol) and a secondary (C-H)⋯O hydrogen bond (2.2 kJ mol); by contrast, in isomer II the (C-H)⋯O hydrogen bond (7.6 kJ mol) becomes the dominant bond, while the OC⋯O tetrel bond (5.8 kJ mol) becomes much weaker with respect to that of isomer I. Using intensity measurements the relative population ratio of the two isomers was estimated to be / ≈ 2/1.
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http://dx.doi.org/10.1039/d1cp03608dDOI Listing
November 2021

two-dimensional quantitative imaging of skin and cutaneous microcirculation with perturbative spatial frequency domain imaging (p-SFDI).

Biomed Opt Express 2021 Oct 9;12(10):6143-6156. Epub 2021 Sep 9.

Institute of Lasers and Biomedical Photonics, Biomedical Engineering College, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.

We introduce perturbative spatial frequency domain imaging (p-SFDI) for fast two-dimensional (2D) mapping of the optical properties and physiological characteristics of skin and cutaneous microcirculation using spatially modulated visible light. Compared to the traditional methods for recovering 2D maps through a pixel-by-pixel inversion, p-SFDI significantly shortens parameter retrieval time, largely avoids the random fitting errors caused by measurement noise, and enhances the image reconstruction quality. The efficacy of p-SFDI is demonstrated by imaging forearm of one healthy subject, recovering the 2D spatial distribution of cutaneous hemoglobin concentration, oxygen saturation, scattering properties, the melanin content, and the epidermal thickness over a large field of view. Furthermore, the temporal and spatial variations in physiological parameters under the forearm reactive hyperemia protocol are revealed, showing its applications in monitoring temporal and spatial dynamics.
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http://dx.doi.org/10.1364/BOE.428243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547977PMC
October 2021

Exosomal lncRNA KLF3-AS1 derived from bone marrow mesenchymal stem cells stimulates angiogenesis to promote diabetic cutaneous wound healing.

Diabetes Res Clin Pract 2021 Nov 3:109126. Epub 2021 Nov 3.

Department of Plastic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, Henan Province, China.

Aims: We focused on BMSC-derived exosomal lncRNA KLF3-AS1 and its significance in diabetic cutaneous wound healing.

Methods: Potential interaction between KLF3-AS1 and miR-383, miR-383 and VEGFA were predicted using bioinformatic analysis and validated by luciferase reporter, RIP, and FISH assays. The proliferation, apoptosis, migration and tube formation of HUVECs were evaluated by CCK-8, flow cytometry, wound healing, and tube formation assays, respectively. A murine diabetic cutaneous wound model was used to investigate therapeutic effects of exosomal KLF3-AS1 in vivo. Histological alterations in skin tissues were examined using HE, Masson staining, and immunostaining of CD31.

Results: BMSC-derived exosomal KLF3-AS1 sufficiently promoted proliferation, migration, and tube formation, while inhibited apoptosis of HUVECs challenged by high glucose. The protective effects of exosomal KLF3-AS1 were achieved at least partially by down-regulating miR-383, and boosting the expression of its target, VEGFA. In vivo, exosomes from KLF3-AS1-expressing BMSCs demonstrated the best effects in promoting cutaneous wound healing in diabetic mice, which were associated with minimal weight loss, increased blood vessel formation, reduced inflammation, decreased miR-383 expression, and up-regulated VEGFA.

Conclusions: Exosomal lncRNA KLF3-AS1 derived from BMSCs induces angiogenesis to promote diabetic cutaneous wound healing.
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http://dx.doi.org/10.1016/j.diabres.2021.109126DOI Listing
November 2021

The role of circular RNAs in neuropathic pain.

Neurosci Biobehav Rev 2021 Nov 2. Epub 2021 Nov 2.

Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China; Department of Rehabilitation Medicine, Shanghai Shangti Orthopaedic Hospital, Shanghai, China. Electronic address:

Neuropathic pain (NP) results from a lesion or disease of the nervous system and accompanied by chronic pain, leading a serious public health issue and economic burden. In terms of the NP mechanisms remaining poorly understood, circular RNAs (circRNAs), owing to their high stability and evolutionary conservation, are expected to be used as potential therapeutic targets or diagnostic biomarkers. In this review, we concisely discuss the characteristics and biological functions of circRNAs. As emerging evidence we reviewed, deregulation of circRNAs (e.g., circ-Filip1l, circHIPK3, ciRS-7, circRNA.2837, circ-Ankib1 and circAnks1a) were involved in NP development. It suggested that specific circRNAs modulated through sponging their target miRNAs and thus regulated the homologous downstream mRNAs and proteins in neuropathic pain. These findings provide a theoretical basis for circRNAs use as biomarkers and therapeutic targets in neuropathic pain.
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http://dx.doi.org/10.1016/j.neubiorev.2021.10.048DOI Listing
November 2021

In silico prediction of Severe Acute Respiratory Syndrome Coronavirus 2 main protease cleavage sites.

Authors:
Zheng Rong Yang

Proteins 2021 Nov 5. Epub 2021 Nov 5.

School of Biosciences, University of Exeter, Exeter, UK.

One of the emerging subjects to combat the SARS-CoV-2 virus is to design accurate and efficient drug such as inhibitors against the viral protease to stop the viral spread. In addition to laboratory investigation of the viral protease, which is fundamental, the in silico research of viral protease such as the protease cleavage site prediction is critically important and urgent. However, this problem has yet to be addressed. This article has, for the first time, investigated this problem using the pattern recognition approaches. The article has shown that the pattern recognition approaches incorporating a specially tailored kernel function for dealing with amino acids has the outstanding performance in the accuracy of cleavage site prediction and the discovery of the prototype cleavage peptides.
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http://dx.doi.org/10.1002/prot.26274DOI Listing
November 2021

Mechanism and prevention strategy of a bidirectional relationship between heart failure and cancer (Review).

Exp Ther Med 2021 Dec 20;22(6):1463. Epub 2021 Oct 20.

Cardiovascular Center, The First Hospital of Jilin University, Jilin University, Changchun, Jilin 130021, P.R. China.

The relationship between cancer and heart failure has been extensively studied in the last decade. These studies have focused on describing heart injury caused by certain cancer treatments, including radiotherapy, chemotherapy and targeted therapy. Previous studies have demonstrated a higher incidence of cancer in patients with heart failure. Heart failure enhances an over-activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system, and subsequently promotes cancer development. Other studies have found that heart failure and cancer both have a common pathological origin, flanked by chronic inflammation in certain organs. The present review aims to summarize and describe the recent discoveries, suggested mechanisms and relationships between heart failure and cancer. The current review provides more ideas on clinical prevention strategies according to the pathological mechanism involved.
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http://dx.doi.org/10.3892/etm.2021.10898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561773PMC
December 2021

The Prognostic Value of LncRNA SLNCR1 in Cancers: A Meta-Analysis.

J Oncol 2021 25;2021:3161714. Epub 2021 Oct 25.

Department of Dermatology, China-Japan Union Hospital of Jilin University, Changchun, China.

Objective: This meta-analysis was performed to identify the prognostic value of SLNCR1 in multiple cancer types.

Methods: Electronic databases, including PubMed, EMBASE, and Web of Science, Cochrane Library, Medline, BioMed Central, Springer, Science Direct, and China National Knowledge Internet (CNKI), were searched for relevant studies up to August 2021, and the hazard ratios (HR) and 95% confidence intervals (95% CI) were calculated to assess the relationship between SLNCR1 expression and overall survival (OS).

Results: 12 studies with a total of 1155 patients with 9 different types of cancers were included in this meta-analysis. The pooled HR indicates that high SLNCR1 expression represented poorer prognosis of cancer (HR = 2.11, 95% CI: 1.59-2.80,  = 0%, < 0.00001). Additionally, high SLNCR1 expression was correlated with TNM stage (odds ratio (OR): 1.72, 95% CI: 1.08-2.74,  = 62%, =0.02), lymph node metastasis (LNM) (OR:2.42, 95% CI: 1.61-3.64,  = 55%, < 0.0001), and distant metastases (DM) (OR: 2.30, 95% CI: 1.50-3.55,  = 27%, =0.0002). However, no evidence was found for a relationship between SLNCR1 expression and clinical features such as tumor size (OR: 1.71, 95% CI: 0.93-3.14,  = 71%, =0.09), age (OR: 0.86, 95% CI: 0.68-1.08,  = 0%, =0.19), or gender (OR: 1.07, 95% CI: 0.64-1.81,  = 55%, =0.79).

Conclusion: Our findings found that high SLNCR1 expression was associated with poor OS, advanced tumor stage, tumor size, LNM, and DM in multiple cancers, indicating that SLNCR1 may serve as a potential prognostic biomarker for cancer patients in China.
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http://dx.doi.org/10.1155/2021/3161714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560271PMC
October 2021

How Does Mentoring Affect the Creative Performance of Mentors: The Role of Personal Learning and Career Stage.

Front Psychol 2021 14;12:741139. Epub 2021 Oct 14.

School of Management and Economics, Beijing Institute of Technology, Beijing, China.

Mentoring has become a vital strategy for improving employee performance and organizational development. A few previous literature studies made a detailed study on the benefits of mentees. The creative performance of mentors that improves from mentoring, however, only draws little attention. This article extends this line of inquiry by shedding light on whether, how, and when mentoring affects the creative performance of mentors, which is a crucial topic in research and practice. Based on the conservation of the resources theory (COR) and relational cultural theory (RCT), this article investigates the influence mechanism and boundary conditions of mentoring on the creative performance of mentors by conducting a multisource empirical study in China. The result shows that there is a positive impact of mentoring on the creative performance of mentors. We also reveal that the relationship is mediated by personal learning, especially the relational job learning dimension. Furthermore, this article finds that the career stage of mentors moderates the relationship between mentoring and personal learning, namely, the relationship is stronger among mentors at the later career stage. The empirical findings show implications for an understanding of how the creative behavior of mentors benefits mentoring and can be beneficial for developing the targeted measures to promote competitive advantages for organizations.
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http://dx.doi.org/10.3389/fpsyg.2021.741139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551566PMC
October 2021

Effect of early cardiac rehabilitation on prognosis in patients with heart failure following acute myocardial infarction.

BMC Sports Sci Med Rehabil 2021 Oct 30;13(1):139. Epub 2021 Oct 30.

The Cardiovascular Center, First Hospital of Jilin University, 71 Xinmin Road, Changchun, 130021, Jilin, China.

Objective: The purpose of this retrospective study is to evaluate the effectiveness of early cardiac rehabilitation on patients with heart failure following acute myocardial infarction.

Methods: Two hundred and thirty-two patients who developed heart failure following acute myocardial infarction were enrolled in this study. Patients were divided into heart failure with reduced ejection fraction group (n = 54) and heart failure with mid-range ejection fraction group (n = 178). Seventy-eight patients who accepted a two-week cardiac rehabilitation were further divided into two subgroups based on major adverse cardiovascular events. Key cardio-pulmonary exercise testing indicators that may affect the prognosis were identified among the cardiac rehabilitation patients.

Results: Early cardiac rehabilitation significantly reduced cardiac death and re-hospitalization in patients. There was more incidence of diabetes, hyperkalemia and low PCO in the cardiac rehabilitation group who developed re-hospitalization. Low PCO at anaerobic threshold (≤ 33.5 mmHg) was an independent risk factor for re-hospitalization.

Conclusions: Early cardiac rehabilitation reduced major cardiac events in patients with heart failure following acute myocardial infarction. The lower PCO at anaerobic threshold is an independent risk factor for re-hospitalization, and could be used as a evaluating hallmark for early cardiac rehabilitation.
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http://dx.doi.org/10.1186/s13102-021-00368-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557619PMC
October 2021

Elevated cytokines and chemokines in peripheral blood of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma.

PLoS Pathog 2021 10 29;17(10):e1010025. Epub 2021 Oct 29.

Hackensack Meridian Health Center for Discovery and Innovation, Nutley, New Jersey, United States of America.

The global SARS-CoV-2 coronavirus pandemic continues to be devastating in many areas. Treatment options have been limited and convalescent donor plasma has been used by many centers to transfer passive neutralizing antibodies to patients with respiratory involvement. The results often vary by institution and are complicated by the nature and quality of the donor plasma itself, the timing of administration and the clinical aspects of the recipients. SARS-CoV-2 infection is known to be associated with an increase in the blood concentrations of several inflammatory cytokines/chemokines, as part of the overall immune response to the virus and consequential to mediated lung pathology. Some of these correlates contribute to the cytokine storm syndrome and acute respiratory distress syndrome, often resulting in fatality. A Phase IIa clinical trial at our institution using high neutralizing titer convalescent plasma transfer gave us the unique opportunity to study the elevations of correlates in the first 10 days after infusion. Plasma recipients were divided into hospitalized COVID-19 pneumonia patients who did not (Track 2) or did (Track 3) require mechanical ventilation. Several cytokines were elevated in the patients of each Track and some continued to rise through Day 10, while others initially increased and then subsided. Furthermore, elevations in MIP-1α, MIP-1β and CRP correlated with disease progression of Track 2 recipients. Overall, our observations serve as a foundation for further study of these correlates and the identification of potential biomarkers to improve upon convalescent plasma therapy and to drive more successful patient outcomes.
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http://dx.doi.org/10.1371/journal.ppat.1010025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580259PMC
October 2021

Tumor Microenvironment Characterization in Breast Cancer Identifies Prognostic and Neoadjuvant Chemotherapy Relevant Signatures.

Front Mol Biosci 2021 11;8:759495. Epub 2021 Oct 11.

Department of Breast Cancer, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Immune response which involves distinct immune cells is associated with prognosis of breast cancer. Nonetheless, less study have determined the associations of different types of immune cells with patient survival and treatment response. In this study, A total of 1,502 estrogen receptor(ER)-negative breast cancers from public databases were used to infer the proportions of 22 subsets of immune cells. Another 320 ER-negative breast cancer patients from Guangdong Provincial People's Hospital were also included and divided into the testing and validation cohorts. CD8 T cells, CD4 T cells, B cells, and M1 macrophages were associated with favourable outcome (all <0.01), whereas Treg cells were strongly associated with poor outcome ( = 0.005). Using the LASSO model, we classified patients into the stromal immunotype A and B subgroups according to immunoscores. The 10 years OS and DFS rates were significantly higher in the immunotype A subgroup than immunotype B subgroup. Stromal immunotype was identified as an independent prognostic indicator in multivariate analysis in all cohorts and was also related to pathological complete response(pCR) after neoadjuvant chemotherapy. The nomogram that integrated the immunotype and clinicopathologic features showed good predictive accuracy for pCR and discriminatory power. The stromal immunotype A subgroup had higher expression levels of immune checkpoint molecules (PD-L1, PD-1, and CTLA-4) and cytokines (IL-2, INF-γ, and TGF-β). In addition, patients with immunotype A and B diseases had distinct mutation signatures. Therefore, The stromal immunotypes could predict survival and responses of ER-negative breast cancer patients to neoadjuvant chemotherapy.
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http://dx.doi.org/10.3389/fmolb.2021.759495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544945PMC
October 2021

Interactions Among lncRNA/circRNA, miRNA, and mRNA in Musculoskeletal Degenerative Diseases.

Front Cell Dev Biol 2021 11;9:753931. Epub 2021 Oct 11.

Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China.

Musculoskeletal degenerative diseases (MSDDs) are pathological conditions that affect muscle, bone, cartilage, joint and connective tissue, leading to physical and functional impairments in patients, mainly consist of osteoarthritis (OA), intervertebral disc degeneration (IDD), rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are novel regulators of gene expression that play an important role in biological regulation, involving in chondrocyte proliferation and apoptosis, extracellular matrix degradation and peripheral blood mononuclear cell inflammation. Research on MSDD pathogenesis, especially on RA and AS, is still in its infancy and major knowledge gaps remain to be filled. The effects of lncRNA/circRNA-miRNA-mRNA axis on MSDD progression help us to fully understand their contribution to the dynamic cellular processes, provide the potential OA, IDD, RA and AS therapeutic strategies. Further studies are needed to explore the mutual regulatory mechanisms between lncRNA/circRNA regulation and effective therapeutic interventions in the pathology of MSDD.
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http://dx.doi.org/10.3389/fcell.2021.753931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542847PMC
October 2021

Laser-triggered combination therapy by iron [email protected] nanozymes for breast cancer therapy.

J Nanobiotechnology 2021 Oct 27;19(1):344. Epub 2021 Oct 27.

Department of Breast Surgery, Harbin Medical University Cancer Hospital, 150 haping Road, Nangang District, Harbin, 150000, China.

Background: The use of magnetic nanozymes (NZs) with the ability to synchronize gas therapy through photodynamic and chemotherapy in the treatment of breast cancer has received much attention.

Results: Hence, in this study, we designed a bovine lactoferrin-coated iron sulfide NZs containing doxorubicin (abbreviated as: [email protected] NZs) by wet-chemical synthesis method. Then, the physicochemical characteristics of synthesized NZs were explored by several methods. Also, the level of Fe, HS and Dox releases from [email protected] NZs. Also, the cytotoxic effects of [email protected] NZs were investigated by cellular assays. After intravenous injections of NZs and laser irradiation, significant effects of [email protected] NZs on mice weight and tumor status were observed. Afterwards, not only the distribution of Dox in the body was examined by fluorescent, but also the time of Fe clearance and the amount of Dox and Fe retention in vital tissues were determined. The findings confirm that [email protected] NZs, in addition to targeted drug distribution in tumor tissue, resulted in superior therapeutic performance compared to free Dox due to reduced Dox side effects in vital tissues, and increased level of free radicals in 4T1 cells.

Conclusion: Overall, [email protected] NZs with the ability to synchronize chemotherapy and gas therapy raised hopes for more effective treatment of breast cancer.
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http://dx.doi.org/10.1186/s12951-021-01023-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554880PMC
October 2021

Long-Acting Tumor-Activated Prodrug of a TGFβR Inhibitor.

J Med Chem 2021 Nov 27;64(21):15787-15798. Epub 2021 Oct 27.

Bristol Myers Squibb, Research and Early Development, P.O. Box 4000, Princeton, New Jersey 08544, United States.

Inhibition of TGFβ signaling in concert with a checkpoint blockade has been shown to provide improved and durable antitumor immune response in mouse models. However, on-target adverse cardiovascular effects have limited the clinical use of TGFβ receptor (TGFβR) inhibitors in cancer therapy. To restrict the activity of TGFβR inhibitors to tumor tissues and thereby widen the therapeutic index, a series of tumor-activated prodrugs of a selective small molecule TGFβR1 inhibitor were prepared by appending to a serine protease substrate and a half-life extension fatty acid carbon chain. The prodrugs were shown to be selectively metabolized in tumor tissues relative to the heart and blood and demonstrated a prolonged favorable increase in the tumor-to-heart ratio of the active drug in tissue distribution studies. Once-weekly administration of the most tissue-selective compound provided anti-tumor efficacy comparable to the parent compound and reduced systemic exposure of the active drug.
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http://dx.doi.org/10.1021/acs.jmedchem.0c02043DOI Listing
November 2021

Oxoammonium Salt-Mediated Regioselective Vicinal Dioxidation of Alkenes: Relying on Transient and Persistent Nitroxides.

Org Lett 2021 Nov 26;23(21):8533-8538. Epub 2021 Oct 26.

Henan Provincial Engineering and Technology Research Center for Precise Synthesis of Fluorine-Containing Drugs, College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, P. R. China.

A novel, easy-to-handle, and regioselective vicinal dioxidation of alkenes under transition metal and organic peroxide free conditions has been developed. This approach uses -hydroxyphthalimide and its analogues as the transient nitroxyl-radical precursors and 2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate (TEMPOBF) as the oxidant as well as the source of persistent nitroxide. By employing this method, multifarious structurally important dioxidation products were efficiently synthesized from simple alkenes and complex bioactive molecule derivatives.
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http://dx.doi.org/10.1021/acs.orglett.1c03196DOI Listing
November 2021
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