Publications by authors named "Yang Xiao"

2,772 Publications

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Analysis of Changes in Weight, Waist Circumference, or Both, and All-Cause Mortality in Chinese Adults.

JAMA Netw Open 2022 Aug 1;5(8):e2225876. Epub 2022 Aug 1.

Department of Epidemiology and Biostatistics, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Importance: Although numerous studies have separately investigated the associations of changes in weight or waist circumference with mortality risk, few studies have examined the associations of concurrent changes in these 2 anthropometric parameters with all-cause mortality.

Objective: To assess the associations of changes in body weight, waist circumference, or both, combined with all-cause mortality.

Design, Setting, And Participants: This cohort study used data from 2 longitudinal cohort studies in Dongfeng-Tongji and Kailuan, China. Participants included 58 132 adults (aged 40 years and older) with measures of weight and waist circumference at baseline and follow-up visit. Statistical analysis was performed from June 2020 to September 2021.

Exposures: Changes in weight and waist circumference between 2 visits (2008-2010 to 2013 in the Dongfeng-Tongji cohort, and 2006-2007 to 2010-2011 in the Kailuan study). Stable weight was defined as change in weight within 2.5 kg between the 2 visits and stable waist circumference was defined as changes within 3.0 cm. Changes were categorized as loss, stable, or gain for weight and waist circumference separately, and created a 9-category variable to represent the joint changes.

Main Outcomes And Measures: All-cause mortality from follow-up visit (2013 in Dongfeng-Tongji cohort and 2010-2011 in Kailuan study) until December 31, 2018. Cox proportional hazard regression models were used to estimate the associations with adjustment for potential confounders. Results were obtained in the 2 cohorts separately and pooled via fixed-effect meta-analysis.

Results: A total of 10 951 participants in the Dongfeng-Tongji cohort (median [IQR] age, 62 [56-66] years; 4203 [38.4%] men) and 47 181 participants in the Kailuan study (median [IQR] age, 51 [46-58] years; 36 663 [77.7%] men) were included in the analysis. During 426 072 person-years of follow-up, 4028 deaths (523 in the Dongfeng-Tongji cohort and 3505 in the Kailuan study) were documented. When changes in weight and waist circumference were examined separately, U-shape associations were found: both gain and loss in weight (weight loss: pooled hazard ratio [HR], 1.33; 95% CI, 1.23-1.43; weight gain: HR, 1.10; 95% CI, 1.02-1.19) or waist circumference (waist circumference loss: HR, 1.14; 95% CI, 1.05-1.24; waist circumference gain: HR, 1.11; 95% CI, 1.03-1.21) were associated with higher mortality risk compared with stable weight or waist group. When changes in weight and waist circumference were jointly assessed, compared with participants with stable weight and waist circumference (16.9% of the total population [9828 of 58 132] with 508 deaths), participants with different combinations of weight and waist circumference change all had higher mortality risks except for those with stable weight but significant loss in waist. Notably, those who lost weight but gained waist circumference (6.4% of the total population [3698 of 58 132] with 308 deaths) had the highest risk of all-cause mortality (HR, 1.69; 95% CI, 1.46-1.96; absolute rate difference per 100 000 person-years in the Dongfeng-Tongji cohort: 414; 95% CI, 116-819; and in the Kailuan study: 333; 95% CI, 195-492) among the joint subgroups.

Conclusions And Relevance: In this cohort study, weight loss with concurrent waist circumference gain was associated with a higher mortality risk in middle-aged and older Chinese adults. This study's findings suggest the importance of evaluating the changes in both body weight and waist circumference when assessing their associations with mortality.
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http://dx.doi.org/10.1001/jamanetworkopen.2022.25876DOI Listing
August 2022

Latent Autoimmune Diabetes in Adults (LADA): From Immunopathogenesis to Immunotherapy.

Front Endocrinol (Lausanne) 2022 21;13:917169. Epub 2022 Jul 21.

National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, China.

Latent autoimmune diabetes in adults (LADA) is a type of diabetes characterized by slow autoimmune damage of pancreatic β cells without insulin treatment in the early clinical stage. There are differences between LADA and classical type 1 diabetes (T1D) and type 2 diabetes (T2D) in genetic background, autoimmune response, rate of islet function decline, clinical metabolic characteristics, and so on. The disease progression and drug response of patients with LADA are closely related to the level of islet autoimmunity, thus exploring the pathogenesis of LADA is of great significance for its prevention and treatment. Previous studies reported that adaptive immunity and innate immunity play a critical role in the etiology of LADA. Recent studies have shown that the intestinal microbiota which impacts host immunity hugely, participates in the pathogenesis of LADA. In addition, the progression of autoimmune pancreatic β cell destruction in LADA is slower than in classical T1D, providing a wider window of opportunities for intervention. Therefore, therapies including antidiabetic drugs with immune-regulation effects and immunomodulators could contribute to promising interventions for LADA. We also shed light on potential interventions targeting the gut microbiota and gut-associated immunity, which may be envisaged to halt or delay the process of autoimmunity in LADA.
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http://dx.doi.org/10.3389/fendo.2022.917169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350734PMC
July 2022

Immune-Related Biomarkers Improve Performance of Risk Prediction Models for Survival in Patients With Hepatocellular Carcinoma.

Front Oncol 2022 22;12:925362. Epub 2022 Jul 22.

Department of Liver Surgery and Liver Transplantation, West China Hospital, Sichuan University, Chengdu, China.

Object: The prediction of hepatocellular carcinoma (HCC) prognosis faced great challenge due to tumor heterogeneity. The purpose of this study was to explore the correlation between the immune infiltrate and prognosis. Moreover, we aimed to establish a risk prediction model for survival in HCC patients based on clinicopathological and immune indicators.

Methods: In this study, 316 patients with HCC who underwent radical resection in West China Hospital from 2009 to 2014 were included. Clinicopathological data and pathological specimens were collected. H&E staining and immunohistochemical staining were performed on the pathological tissue sections. The evaluation of tumor-infiltrating lymphocyte (TIL) density was based on H&E slices, and the assessment of the expressions of CD8, CD68, Lymphocyte activation gene-3 (LAG-3), T cell immunoglobulin domain and mucin domain-3 (TIM-3), Programmed Cell Death Protein 1 (PD-1), Programmed Cell Death Ligand 1 (PD-L1), OX40, CD66b, and Tryptase. was performed on the immunohistochemical slices. A risk prediction model for survival in HCC patients was established by integrating immune-related biomarkers and clinicopathological indicators.

Results: The Barcelona Clinic Liver Cancer (BCLC) stage; the microvascular invasion status; the density of TILs; the expressing levels of CD66b, OX40, and PD-L1 in the immune cell; CD68; and CD8 were the predictors of patients' overall survival (OS). The BCLC stage; the density of TILs; and the expressions of OX40, CD68, and CD8 were associated with disease-free survival (DFS). The expressions of CD66b, CD68, OX40, and CD8 had a cumulative effect on prognosis. The area under the curve of the prediction model for OS based on clinicopathological features was improved from 0.62 to 0.74 by adding to CD8, OX40, CD68, CD66b, and TILs, whereas it was improved from 0.59 to 0.73 for the DFS prediction model.

Conclusion: Our results, if confirmed, indicated that immune-related biomarkers should be taken into account or stratified in survival analysis for HCC.
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http://dx.doi.org/10.3389/fonc.2022.925362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353009PMC
July 2022

Decreased modular segregation of the frontal-parietal network in major depressive disorder.

Front Psychiatry 2022 22;13:929812. Epub 2022 Jul 22.

Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.

Major depressive disorder (MDD) is a common psychiatric condition associated with aberrant large-scale distributed brain networks. However, it is unclear how the network dysfunction in MDD patients is characterized by imbalance or derangement of network modular segregation. Fifty-one MDD patients and forty-three matched healthy controls (HC) were recruited in the present study. We analyzed intrinsic brain activity derived from resting-state functional magnetic resonance imaging (R-fMRI) and then examined brain network segregation by computing the participation coefficient (PC). Further intra- and inter-modular connections analysis were preformed to explain atypical PC. Besides, we explored the potential relationship between the above graph theory measures and symptom severity in MDD. Lower modular segregation of the frontal-parietal network (FPN) was found in MDD compared with the HC group. The MDD group exhibited increased inter-module connections between the FPN and cingulo-opercular network (CON), between the FPN and cerebellum (Cere), between the CON and Cere. At the nodal level, the PC of the anterior prefrontal cortex, anterior cingulate cortex, inferior parietal lobule (IPL), and intraparietal sulcus showed larger in MDD. Additionally, the inter-module connections between the FPN and CON and the PC values of the IPL were negatively correlated with depression symptom in the MDD group. These findings might give evidence about abnormal FPN in MDD from the perspective of modular segregation in brain networks.
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http://dx.doi.org/10.3389/fpsyt.2022.929812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353222PMC
July 2022

Individual and joint associations of co-exposure to multiple plasma metals with telomere length among middle-aged and older Chinese in the Dongfeng-Tongji cohort.

Environ Res 2022 Aug 4:114031. Epub 2022 Aug 4.

Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, And State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. Electronic address:

Studies on associations of metals with leucocyte telomere length (LTL) were mainly limited to several most common toxic metals and single-metal effect, but the impact of other common metals and especially the overall joint associations and interactions of metal mixture with LTL are largely unknown. We included 15 plasma metals and LTL among 4906 participants from Dongfeng-Tongji cohort. Multivariable linear regression was used to estimate associations of individual metals with LTL. We also applied Bayesian kernel machine regression (BKMR) and quantile g-computation regression (Q-g) to evaluate the overall association and interactions, and identified the major contributors as well as the potential modifications by major characteristics. Multivariable linear regression found vanadium, copper, arsenic, aluminum and nickel were negatively associated with LTL, and a 2-fold change was related to 1.9%-5.1% shorter LTL; while manganese and zinc showed 3.7% and 4.0% longer LTL (all P < 0.05) in multiple-metal models. BKMR confirmed above metals and revealed a linearly inverse joint association between 15 metals and LTL. Q-g regression further indicated each quantile increase in mixture was associated with 5.2% shorter LTL (95% CI: -8.1%, -2.3%). Furthermore, manganese counteracted against aluminum and vanadium respectively (P<0.05). In addition, associations of vanadium, aluminum and metal mixture with LTL were more prominent in overweight participants. Our results are among the first to provide a new comprehensive view of metal mixture exposure on LTL attrition in the general population, including identifying the major components, metals interactions and the overall effects.
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http://dx.doi.org/10.1016/j.envres.2022.114031DOI Listing
August 2022

In vivo phytotoxic effect of yttrium-oxide nanoparticles on the growth, uptake and translocation of tomato seedlings (Lycopersicon esculentum).

Ecotoxicol Environ Saf 2022 Aug 2;242:113939. Epub 2022 Aug 2.

University of Wuppertal, School of Architecture and Civil Engineering, Institute of Foundation Engineering, Water, and Waste-Management, Laboratory of Soil, and Groundwater-Management, Pauluskirchstraße 7, 42285 Wuppertal, Germany; International Research Centre of Nanotechnology for Himalayan Sustainability (IRCNHS), Shoolini University, Solan 173212, Himachal Pradesh, India. Electronic address:

The potential toxicity and ecological risks of rare-earth nanoparticles in the environment have become a concern due to their widespread application and inevitable releases. The integration of hydroponics experiments, partial least squares structural equation modeling (PLS-SEM), and Transmission Electron Microscopy (TEM) were utilized to investigate the physiological toxicity, uptake and translocation of yttrium oxide nanoparticles (YO NPs) under different hydroponic treatments (1, 5, 10, 20, 50 and 100 mg·L of YO NPs, 19.2 mg·L Y(NO) and control) in tomato (Lycopersicon esculentum) seedlings. The results indicated that YO NPs had a phytotoxic effect on tomato seedlings' germination, morphology, physiology, and oxidative stress. The YO NPs and soluble Y reduced the root elongation, bud elongation, root activity, chlorophyll, soluble protein content and superoxide dismutase and accelerated the proline and malondialdehyde in the plant with increasing concentrations. The phytotoxic effects of YO NPs on tomato seedlings had a higher phytotoxic effect than soluble Y under the all treatments. The inhibition rates of different levels of YO NPs in shoot and root biomass ranged from 0.2% to 6.3% and 1.0-11.3%, respectively. The bioaccumulation and translocation factors were less than 1, which suggested that YO NPs significantly suppressed shoot and root biomass of tomato seedlings and easily bioaccumulated in the root. The observations were consistent with the process of concentration-dependent uptake and translocation factor and confirmed by TEM. YO NPs penetrate the epidermis, enter the cell wall, and exist in the intercellular space and cytoplasm of mesophyll cells of tomato seedlings by endocytic pathway. Moreover, PLS-SEM revealed that the concentration of NPs significantly negatively affects the morphology and physiology, leading to the change in biomass of plants. This study demonstrated the possible pathway of YO NPs in uptake, phytotoxicity and translocation of YO NPs in tomato seedlings.
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http://dx.doi.org/10.1016/j.ecoenv.2022.113939DOI Listing
August 2022

[Family analysis of a child with Short-rib polydactyly syndrome type III due to variant of DYNC2H1 gene].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2022 Aug;39(8):881-883

Reproductive Center and Prenatal Diagnosis Center, the First Hospital of Jilin University, Changchun, Jilin 130021, China.

Objective: To report on the clinical characteristics of a family of short-rib polydactyly syndrome type III and its pathogenic variants.

Methods: Muscle samples from the the third fetus was collected after the induction of labor, and peripheral blood samples of its parents and grandparents were also collected. Whole exome sequencing (WES) was carried out for the pedigree. Candidate variants were verified by Sanger sequencing of the family.

Results: The proband was found to harbor a c.9819+1G>A variant and a c.4625C>A variant of the DYNC2H1 gene, which were respectively inherited from its mother and father. Sanger sequencing verified that the family has fit the autosomal recessive inheritance.

Conclusion: The c.9819+1G>A and c.4625C>A variants of the DYNC2H1 gene probably underlay the short-rib polydactyly syndrome type 3 in the proband.
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http://dx.doi.org/10.3760/cma.j.cn511374-20210628-00549DOI Listing
August 2022

Expandable, biodegradable, bioactive quaternized gelatin sponges for rapidly controlling incompressible hemorrhage and promoting wound healing.

Biomater Adv 2022 May 29;136:212776. Epub 2022 Mar 29.

Department of Intensive Care, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China. Electronic address:

Designing expandable sponges with biodegradability and effective antibacterial properties are the urgent challenge for incompressible hemorrhage and wound healing. In the present investigation, based on quaternized gelatin (QG) and oxidized dextran (OD), a series of expandable sponges (ODQG) with high-water absorption capacity and robust mechanical properties were prepared. ODQG had good biodegradability in vitro and in vivo, and had inherent antibacterial activity (90% for E. coli and 99.74% for S. aureus). Due to the synergy effect of electrostatic interaction and blood concentration, ODQG could effectively attract and activate red blood cells/platelets and accelerate the coagulation process. Therefore, ODQG showed better hemostatic performance than Kuaikang® gelatin sponges and gauzes in incompressible hemorrhage model. Furthermore, ODQG could regulate inflammatory factor (TNF-α) and cytokines (TGF-β, VEGF), and greatly promote wound healing process. The biodegradable sponges with excellent antibacterial properties might have potential application prospect for incompressible hemostasis and wound healing in the future.
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http://dx.doi.org/10.1016/j.bioadv.2022.212776DOI Listing
May 2022

Controlling sustained statins release in multi-layered composite scaffolds for healing of osteoporotic bone defects.

Biomater Adv 2022 Jun 5;137:212838. Epub 2022 May 5.

Department of Orthopaedic Surgery, Sichuan Provincial People's Hospital, Sichuan Academy of Medical Science, Affiliated Hospital of University of Electronic Science and Technology, Chengdu 610072, China. Electronic address:

The risk of fragility fracture sharply increases due to the decreased bone mineral density and toughness in patients with osteoporosis (OP). The local use of bone tissue scaffolds with both mechanical stability and drug-delivery functionality is one of the key strategies for the efficient curing of OP. In this work, we reported a layer-by-layer constructing strategy to fabricate 3-D composite bone tissue scaffolds (eSTPS) by assembling β-tri‑calcium phosphate (β-TCP)/polycaprolactone (PCL) microchips and lovastatin-loaded nanofiber membranes (eLOV/PCL). The eSTPS scaffolds show a strong and suited compressive strength as well as long-term delivery of lovastatin. The in vitro tests indicate well biocompatibility and alkaline phosphatase activity of the scaffolds. The eSTPS scaffolds were implanted into the femur of OP modeled rabbits. After 12 weeks curing, the bone parameters are significantly improved, meanwhile ingrowth of new bone and vascular-like tissue were observed. These results suggest the eSTPS scaffolds to be a promising candidate for the local treatment of OP.
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http://dx.doi.org/10.1016/j.bioadv.2022.212838DOI Listing
June 2022

[A comparison of clinical characteristics between acute fatty liver of pregnancy and hemolysis, elevated liver enzymes and low platelets syndrome].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2022 Jun;34(6):624-629

Department of Critical Care Medicine, Yan'an Hospital of Kunming City, Kunming 650051, Yunnan, China. Corresponding author: Xu Wangbin, Email:

Objective: To compare and analyze the clinical characteristics between acute fatty liver of pregnancy (AFLP) and the hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome.

Methods: This is a retrospective cohort study. The clinical data of 13 cases with AFLP and 34 cases with HELLP syndrome were collected from three tertiary referral centers in Yunnan (the First Affiliated Hospital of Kunming Medical University, the Second Affiliated Hospital of Kunming Medical University, and Yan'an Hospital of Kunming City) from January 2016 to December 2021. The patients were diagnosed to AFLP and HELLP syndrome according to the Swansea criteria and the Tennessee classification system. The general characteristics, clinical features, laboratory results within 24 hours after admission, complications, maternal and neonatal outcomes were compared to analysis the differences between the two groups.

Results: (1) Maternal characteristics: compared with HELLP syndrome group, AFLP group had lower body mass index (BMI) and blood pressure at admission (both P < 0.01). (2) Clinical features: the most common symptoms in AFLP patients were skin jaundice, abdominal pain, nausea and vomiting, edema. The main manifestations of patients with HELLP syndrome were albuminuria, hypertension, edema, headache. Some patients had multiple symptoms concurrently. (3) Laboratory results: compared with HELLP syndrome group, the levels of platelet count (PLT), total bilirubin (TBil), direct bilirubin (DBil), γ-glutamyl transferase (γ-GGT), alkaline phosphatase (ALP), total bile acid (TBA), serum creatinine (SCr) and international standardized ratio (INR) in AFLP group were significantly increased within 24 hours after admission [PLT (×10/L): 107.69±51.13 vs.76.71±43.25,TBil (μmol/L): 121.60 (83.20, 170.00) vs.15.25 (7.22, 29.05), DBil (μmol/L): 86.50 (58.60, 104.00) vs. 4.30 (2.22,10.10), γ-GGT (U/L): 87.00 (37.00, 127.00) vs. 41.00 (19.00,64.42), ALP (U/L): 199.10 (109.00, 349.20) vs. 125.50 (90.50, 155.25), TBA (μmol/L): 51.50 (16.20, 117.40) vs. 4.15 (2.02, 6.95), SCr (μmol/L): 155.80 (129.00, 237.00) vs. 79.00 (65.43, 113.70), INR: 1.28 (1.17, 1.63) vs. 0.94 (0.88, 1.08), all P < 0.05], prothrombin time (PT) was significantly prolonged [seconds: 16.10 (14.50, 19.20) vs. 12.40 (11.43, 13.40), P < 0.05]. The level of blood glucose (GLU), fibrinogen (FIB) and the activity of antithrombin III (AT III) decreased significantly [GLU (mmol/L): 5.18±1.33 vs. 6.33±1.19, FIB (g/L): 1.96±1.46 vs. 3.81±1.58, AT III (%): 40.61±25.84 vs. 66.39±24.11, all P < 0.05]; (4) Complications: compared with HELLP syndrome group, the incidence of patients with hypoglycemia [30.77% (4/13) vs. 0% (0/34)], acute liver failure [53.85% (7/13) vs. 5.88% (2/34)], acute renal insufficiency [69.23% (9/13) vs. 8.82% (3/34)], coagulopathy [76.92% (10/13) vs. 38.24% (13/34)], disseminated intravascular coagulation (DIC) [53.85% (7/13) vs. 5.88% (2/34)], and multiple organ dysfunction syndrome (MODS) [53.85% (7/13) vs. 5.88% (2/34)] were significantly higher in AFLP group (all P <0.05). (5) Maternal and neonatal outcome: all patients delivered after admission. The total length of hospital and intensive care unit stay were significantly longer in the AFLP group than in the HELLP syndrome group [days: 17.00 (11.00, 25.00) vs. 9.00 (7.00, 12.00), 12.00 (4.00, 22.00) vs. 3.91 (0, 7.00), both P < 0.01]. Two AFLP patients died, including one due to intracranial venous thrombosis and one due to multiple organ failure and cardiopulmonary arrest. There were no deaths in the HELLP syndrome group.

Conclusions: There are significant differences in maternal characteristics, laboratory results and complications between AFLP and HELLP syndrome. TBil, γ-GGT, SCr, FIB, INR and AT III activity may help to distinguish the two diseases.
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http://dx.doi.org/10.3760/cma.j.cn121430-20220411-00361DOI Listing
June 2022

Characterization of the complete mitochondrial genome of and phylogenetic studies of Sisoridae.

Mitochondrial DNA B Resour 2022 28;7(7):1408-1409. Epub 2022 Jul 28.

Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, China.

The entire mitochondrial genome (mitogenome) of was sequenced; it spanned 16,536 bp in length and contained 13 protein-coding genes (PCGs), 2 ribosomal RNAs, and 22 transfer RNA genes. A total of 37 genes formed a typical vertebrate mitochondrial gene arrangement. The phylogenetic tree of Sisoridae based on 13 PCGs was constructed and supported that was closely related to , , , and . The mitogenome of described in this study provided molecular evidence for its current taxonomic status and laid a groundwork for further study concerning phylogenetics within Sisoridae.
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http://dx.doi.org/10.1080/23802359.2022.2093666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9341339PMC
July 2022

The pattern glare and visual memory are disrupted in patients with major depressive disorder.

BMC Psychiatry 2022 08 2;22(1):518. Epub 2022 Aug 2.

Psychiatric Laboratory and Mental Health Center, West China Hospital of Sichuan University, Chengdu, China.

Background: Visual memory impairment is one of the most commonly complained symptoms in patients with major depressive disorder (MDD). Pattern glare is also a distorted visual phenomenon that puzzles patients with MDD. Nevertheless, how these two phenomena interact in MDD remains unknown. This study investigated the association between pattern glare and visual memory in MDD patients.

Methods: Sixty-two patients with MDD and forty-nine age-, sex- and education level-matched healthy controls (HCs) were included in this study. The Pattern Recognition Memory (PRM) test and the Brief Visual Memory Test-Revised (BVMT-R) were applied to measure visual memory. The pattern glare test including three patterns with different spatial frequencies (SFs) was used to explore pattern glare levels.

Results: Patients with MDD scored lower on the PRM-PCi, BVMT-R1, BVMT-R2, BVMT-R3, and BVMT-Rt and higher on the PRM-MCLd than HCs (all p < 0.05). Pattern glare scores for MDD patients were higher with mid-SF (p < 0.001), high-SF (p = 0.006) and mid-high SF differences (p = 0.01) than for HCs. A positive correlation between mid-SF and PRM-MCLd scores in all participants was observed (p = 0.01, r = 0.246). A negative correlation between mid-high difference scores and BVMT-R2 scores (p = 0.032, r = -0.317) was observed in HCs, but no significant correlation was observed in MDD patients.

Conclusions: The present study showed that visual memory and pattern glare are disrupted in MDD. Visual memory may be associated with pattern glare and needs to be studied in future work.
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http://dx.doi.org/10.1186/s12888-022-04167-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344705PMC
August 2022

Organic covalent modification to improve thermoelectric properties of TaS.

Nat Commun 2022 Jul 29;13(1):4401. Epub 2022 Jul 29.

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.

Organic semiconductors are attracting considerable attention as a new thermoelectric material because of their molecular diversity, non-toxicity and easy processing. The side chains which are introduced into two-dimensional (2D) transition metal dichalcogenides (TMDs) by covalent modification lead to a significant decrease in their thermal conductivity. Here, we describe a simple approach to preparing the side chains covalent modification TaS (SCCM-TaS) organic/inorganic hybrid structures, which is a homogeneous and non-destructive technique that does not depend on defects and boundaries. Electrical conductivity of 3,401 S cm and a power factor of 0.34 mW m K are obtained for a hybrid material of SCCM-TaS, with an in-plane thermal conductivity of 4.0 W m K, which is 7 times smaller than the thermal conductivity of the pristine TaS crystal. The power factor and low thermal conductivity contribute to a thermoelectric figure of merit (ZT) of ~0.04 at 443 K.
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http://dx.doi.org/10.1038/s41467-022-32058-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338255PMC
July 2022

Indocyanine green for targeted imaging of the gall bladder and fluorescence navigation.

J Biophotonics 2022 Jul 29:e202200142. Epub 2022 Jul 29.

Scientific Research Center and Precision Medical Institute, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.

Researchers nowadays have devoted extra attention to the different biomedical applications of indocyanine green (ICG), a US Food and Drug Administration (FDA)-approved fluorescent compound in the fields such as drug delivery, medical imaging, and disease diagnosis. In addition, hepatic function evaluation could be conducted by using ICG before surgical procedures and angiographic assessment of blood. Therefore, ICG will be expected to be excellent imaging and targeting agent in various preclinical and clinical model systems. However, whether ICG possesses the potential for the gall bladder's intraoperative imaging guidance needs to be further explored in vivo animal experiments. Herein, NIR fluorophores ICG can display the specific uptake by the gall bladder cells and tissues. The dynamic process of biodistribution and the clearance of ICG in vivo in mice are clearly shown in real-time live-body imaging. Furthermore, ICG was rapidly excreted into the bile and lately biodistributed to the stomach after treatment in mice. Meanwhile, the signal-to-background ratio (SBR) of the gall bladder demonstrated a tremendously higher level compared to other organs (stomach, heart, liver, lung, pancreas, spleen, intestine, and duodenum). In conclusion, fluorescence navigation using ICG fluorescence imaging will provide good visualization and detection of the target lesions (gall bladder) in clinics such as diagnostic medical imaging and intraoperative navigation. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/jbio.202200142DOI Listing
July 2022

Two Children With Steroid-Resistant Significant Proteinuria Due to Nonsense Mutations of the Gene: A Case Report and Literature Review.

Front Pediatr 2022 12;10:918373. Epub 2022 Jul 12.

Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Background: gene mutations have been reported as the genetic basis of autosomal dominant (AD) neuro-renal syndrome in children, which presents with epileptic encephalopathy, focal segmental glomerulosclerosis (FSGS), developmental delay, and mental retardation. In this study, we report the cases of two children with significant proteinuria due to de novo nonsense mutations of the gene.

Case Presentation: Case 1 was a 7-year-old girl who presented with proteinuria and developmental delay, and her renal biopsy showed FSGS. She developed end-stage renal disease (ESRD) 3 years after onset. Case 2 was another 7-year-old girl who developed proteinuria only at age 3, and renal biopsy showed glomerular segmental mesangial proliferative lesions. The two girls underwent genetic testing but we did not find a positive result in the whole exon. However, cluster analysis revealed two new nonsense mutations of the gene (c.1461C>A, p.Tyr 487 and c.1453C>T, p.Gln485).

Conclusions: We reported the clinical manifestation of this neuro-renal syndrome for the first time in China. It is necessary to perform genetic testing in children with steroid-resistant significant proteinuria to identify its etiology and avoid the side effects of immunosuppressants.
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http://dx.doi.org/10.3389/fped.2022.918373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315245PMC
July 2022

Abnormal Dynamic Functional Connectivity of the Left Rostral Hippocampus in Predicting Antidepressant Efficacy in Major Depressive Disorder.

Psychiatry Investig 2022 Jul 21;19(7):562-569. Epub 2022 Jul 21.

Center for Cognition and Brain Disorders, The Affiliated Hospital and Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.

Objective: Some pharmacological treatments are ineffective in parts of patients with major depressive disorder (MDD), hence this needs prediction of effective treatment responses. The study aims to examine the relationship between dynamic functional connectivity (dFC) of the hippocampal subregion and antidepressant improvement of MDD patients and to estimate the capability of dFC to predict antidepressant efficacy.

Methods: The data were from 70 MDD patients and 43 healthy controls (HC); the dFC of hippocampal subregions was estimated by sliding-window approach based on resting-state functional magnetic resonance imaging (R-fMRI). After 3 months treatment, 36 patients underwent second R-fMRI scan and were then divided into the response group and non-response group according to clinical responses.

Results: The result manifested that MDD patients exhibited lower mean dFC of the left rostral hippocampus (rHipp.l) compared with HC. After 3 months therapy, the response group showed lower dFC of rHipp.l compared with the non-response group. The dFC of rHipp.l was also negatively correlated with the reduction rate of Hamilton Depression Rating Scale.

Conclusion: These findings highlighted the importance of rHipp in MDD from the dFC perspective. Detection and estimation of these changes might demonstrate helpful for comprehending the pathophysiological mechanism and for assessment of treatment reaction of MDD.
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http://dx.doi.org/10.30773/pi.2021.0386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334807PMC
July 2022

Cross-platform analysis reveals cellular and molecular landscape of glioblastoma invasion.

Neuro Oncol 2022 Jul 28. Epub 2022 Jul 28.

Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.

Background: Improved treatment of glioblastoma (GBM) needs to address tumor invasion, a hallmark of the disease that remains poorly understood. In this study, we profiled GBM invasion through integrative analysis of histological and single-cell RNA sequencing (scRNA-seq) data from ten patients.

Methods: Human histology samples, patient-derived xenograft mouse histology samples, and scRNA-seq data were collected from ten GBM patients. Tumor invasion was characterized and quantified at the phenotypic level using H&E and Ki-67 histology stains. Crystallin alpha B (CRYAB) and CD44 were identified as regulators of tumor invasion from scRNA-seq transcriptomic data and validated in vitro, in vivo, and in a mouse GBM resection model.

Results: At the cellular level, we found that invasive GBM are less dense and proliferative than their non-invasive counterparts. At the molecular level, we identified unique transcriptomic features that significantly contribute to GBM invasion. Specifically, we found that CRYAB significantly contributes to post-operative recurrence and is highly co-expressed with CD44 in invasive GBM samples.

Conclusions: Collectively, our analysis identifies differentially expressed features between invasive and nodular GBM, and describes a novel relationship between CRYAB and CD44 that contributes to tumor invasiveness, establishing a cellular and molecular landscape of GBM invasion.
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http://dx.doi.org/10.1093/neuonc/noac186DOI Listing
July 2022

Prediction of biomarker-disease associations based on graph attention network and text representation.

Brief Bioinform 2022 Jul 29. Epub 2022 Jul 29.

College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, 518000, China.

Motivation: The associations between biomarkers and human diseases play a key role in understanding complex pathology and developing targeted therapies. Wet lab experiments for biomarker discovery are costly, laborious and time-consuming. Computational prediction methods can be used to greatly expedite the identification of candidate biomarkers.

Results: Here, we present a novel computational model named GTGenie for predicting the biomarker-disease associations based on graph and text features. In GTGenie, a graph attention network is utilized to characterize diverse similarities of biomarkers and diseases from heterogeneous information resources. Meanwhile, a pretrained BERT-based model is applied to learn the text-based representation of biomarker-disease relation from biomedical literature. The captured graph and text features are then integrated in a bimodal fusion network to model the hybrid entity representation. Finally, inductive matrix completion is adopted to infer the missing entries for reconstructing relation matrix, with which the unknown biomarker-disease associations are predicted. Experimental results on HMDD, HMDAD and LncRNADisease data sets showed that GTGenie can obtain competitive prediction performance with other state-of-the-art methods.

Availability: The source code of GTGenie and the test data are available at: https://github.com/Wolverinerine/GTGenie.
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http://dx.doi.org/10.1093/bib/bbac298DOI Listing
July 2022

Isolation of Bioactive Compounds, Antibacterial Activity, and Action Mechanism of Spore Powder From xj.

Front Microbiol 2022 11;13:934857. Epub 2022 Jul 11.

Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), College of Life Sciences, Institute of Agro-Bioengineering, Guizhou University, Guiyang, China.

fungi can produce a wide range of secondary metabolites, and they have represented a potential resource of novel bioactive compounds. Bacterial plant diseases have a serious impact on the sustainable development of agriculture worldwide, so it is necessary to use natural antibacterial compounds in microorganisms to control plant pathogens. This study was conducted to investigate the bioactive compounds of xj, three plant pathogens ( T-37, EC-1, and RS-2) were used as indicator bacteria, according to the biological activity tracking, five compounds were isolated from xj spore powder, and characterization of compounds was done by NMR (H-NMR and C-NMR) and EI-MS and was identified as ergosterol (1), β-sitosterol (2), 5-pentadecylresorcinol (3), 5-hydroxymethyl-2-furancarboxylic acid (4), and succinimide (5). Compounds 3 and 5 were isolated from xj for the first time. The minimum inhibitory concentration (MIC) of five compounds against three plant pathogens was evaluated, the results showed that compound 4 exhibited the strongest antibacterial activity against tested bacteria, and RS-2 was the most sensitive to compound 4, showing the lowest MIC of 15.56 μg/ml. We concluded that the mechanism of action of the compound 4 against RS-2 might be described as compound 4 acting on bacterial protein synthesis and intracellular metabolism according to the results of the scanning electron microscopy observation, permeability of cell membrane and SDS-PAGE. These results indicated that compound 4 has good potential to be as a biocontrol agent. In conclusion, the results from this study demonstrated that the compounds with antibacterial activity are of great significance of the prevention and control of plant phytopathogenic bacteria, and they may be applicable to exploring alternative approaches to integrated control of phytopathogens.
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http://dx.doi.org/10.3389/fmicb.2022.934857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309528PMC
July 2022

Role of the Glyoxalase System in Breast Cancer and Gynecological Cancer-Implications for Therapeutic Intervention: a Review.

Front Oncol 2022 8;12:857746. Epub 2022 Jul 8.

Peking University People's Hospital, Beijing, China.

Methyglyoxal (MGO), an essential endogenous dicarbonyl metabolite, can lead to multiple physiological problems including hyperglycemia, kidney diseases, malignant tumors, beyond its normal concentration range. The glyoxalase system, making MGO maintained at a low level, links glycation to carcinogenesis, growth, metastasis, and cancer chemotherapy. The glyoxalase system comprises glyoxalase 1 (Glo1) and glyoxalase 2 (Glo2), which is often overexpressed in various tumor tissues. However, very little is known about the glyoxalase system in breast cancer and gynecological cancer. In this review, we introduce the role of the glyoxalase system in breast cancer, endometrial cancer, ovarian cancer and cervical cancer, and highlight the potential of the glyoxalase system to be both as a marker for diagnosis and a novel target for antitumor therapy. However, the intrinsic molecular biology and mechanisms of the glyoxalase system in breast cancer and gynecological cancer need further exploration.
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http://dx.doi.org/10.3389/fonc.2022.857746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309216PMC
July 2022

Mechano-Enzymatic Degradation of the Chitin from Crustacea Shells for Efficient Production of N-acetylglucosamine (GlcNAc).

Molecules 2022 Jul 23;27(15). Epub 2022 Jul 23.

Zaozhuang Chengmei Environmental Engineering Consulting Co., Ltd., Linyi 276000, China.

Chitin, the second richest polymer in nature, is composed of the monomer N-acetylglucosamine (GlcNAc), which has numerous functions and is widely applied in the medical, food, and chemical industries. However, due to the highly crystalline configuration and low accessibility in water of the chitin resources, such as shrimp and crab shells, the chitin is difficult utilize, and the traditional chemical method causes serious environment pollution and a waste of resources. In the present study, three genes encoding chitinolytic enzymes, including the N-acetylglucosaminidase from (), endo-chitinase from (), and multifunctional chitinase from (), were expressed in the system, and the positive transformants with multiple copies were isolated by the PTVA (post-transformational vector amplification) method, respectively. The three recombinants OfHex1, TvChi1, and CmChi1 were induced by methanol and purified by the chitin affinity adsorption method. The purified recombinants OfHex1 and TvChi1 were characterized, and they were further used together for degrading chitin from shrimp and crab shells to produce GlcNAc through liquid-assisted grinding (LAG) under a water-less condition. The substrate chitin concentration reached up to 300 g/L, and the highest yield of the product GlcNAc reached up to 61.3 g/L using the mechano-enzymatic method. A yield rate of up to 102.2 g GlcNAc per 1 g enzyme was obtained.
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http://dx.doi.org/10.3390/molecules27154720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331973PMC
July 2022

Recent Progress on Bioinspired Antibacterial Surfaces for Biomedical Application.

Biomimetics (Basel) 2022 Jul 4;7(3). Epub 2022 Jul 4.

Department of Mechanical Engineering, City University of Hong Kong, Kowloon, Hong Kong 999077, China.

Surface bacterial fouling has become an urgent global challenge that calls for resilient solutions. Despite the effectiveness in combating bacterial invasion, antibiotics are susceptible to causing microbial antibiotic resistance that threatens human health and compromises the medication efficacy. In nature, many organisms have evolved a myriad of surfaces with specific physicochemical properties to combat bacteria in diverse environments, providing important inspirations for implementing bioinspired approaches. This review highlights representative natural antibacterial surfaces and discusses their corresponding mechanisms, including repelling adherent bacteria through tailoring surface wettability and mechanically killing bacteria via engineering surface textures. Following this, we present the recent progress in bioinspired active and passive antibacterial strategies. Finally, the biomedical applications and the prospects of these antibacterial surfaces are discussed.
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http://dx.doi.org/10.3390/biomimetics7030088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326651PMC
July 2022

The Effect of Grain Size on the Diffusion Efficiency and Microstructure of Sintered Nd-Fe-B Magnets by Tb Grain Boundary Diffusion.

Materials (Basel) 2022 Jul 18;15(14). Epub 2022 Jul 18.

CISRI & NIMTE Joint Innovation Center for Rare Earth Permanent Magnets, Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.

The grain boundary diffusion process (GBDP) of heavy rare earth Tb is an effective method to improve the coercivity of Nd-Fe-B magnets, and the matrix grain size has a crucial effect on the diffusion efficiency and depth of the Tb element. In this work, magnets with different grain sizes have been fabricated using powder metallurgy to investigate the effect of grain size on Tb diffusion efficiency and the microstructure of Nd-Fe-B-type magnets. After the Tb diffusion process, the coercivity increment of the magnet with 4.9 μm large grain is 8.60 kOe, which is much higher than that of the magnet with 3.0 μm small grain (~5.90 kOe), which clearly demonstrates that the coercivity increment decreases as the grain size decreases. Microstructure analysis suggested that grain refinement significantly increases the total surface area, resulting in narrowing and discontinuity of the grain boundary phase (GBP). Therefore, as the channel for diffusion, the narrowing and discontinuity of the GBP are unfavorable for diffusion, resulting in a decrease in diffusion efficiency.
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http://dx.doi.org/10.3390/ma15144987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319959PMC
July 2022

Cross-Cultural Adaptation and Validation of the Fear of COVID-19 Scale for Chinese University Students: A Cross-Sectional Study.

Int J Environ Res Public Health 2022 Jul 15;19(14). Epub 2022 Jul 15.

CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.

Background: fear of COVID-19 is widespread among the population, especially among college students because of their increased exposure to the media information overload of the COVID-19 outbreak. The Fear of COVID-19 scale (FCV-19 S) is a relatively short instrument used to evaluate fears surrounding the COVID-19 pandemic. However, the validity and reliability of the Fear of COVID-19 Scale have not been fully investigated in Chinese university student groups.

Objectives: this study assessed the cross-cultural adaptability and reliability of the FCV-19S for Chinese university students.

Methods: a Chinese version of Fear of COVID-19 Scale (C-FCV-19S) was generated using the translation-backward translation method. Psychometric properties of the C-FCV-19S, including internal consistency, split-half reliability, construct reliability, convergent validity, and diagnostic accuracy, were evaluated. The Patient Health Questionnaire (PHQ) and Generalized Anxiety Disorder Questionnaire (GAD-7) scales were also used to evaluate participants for depression and anxiety.

Results: the C-FCV-19S has acceptable internal consistency (Cronbach's alpha: 0.872) and satisfactory split-half reliability (correlation coefficient: 0.799). Using the exploratory factor analysis (EFA), we examined the construct reliability (KMO = 0.920). The confirmatory factor analysis (CFA) confirmed that the bifactor model of scale (including general factor, factor1: the awareness of COVID-19 and physiological arousal, factor 2: fear-related thinking) had a good fit index (χ2/df =6.18, RMSEA= 0.067, SRMR = 0.028, GFI = 0.986, TLI = 0.970 and CFI= 0.988). Using depression-positive and anxiety-positive scores as reference criteria, we found that the areas under the curve were 0.70 and 0.68, respectively, and that the optimal cutoff scores of the C-FCV-19S was 17.5 (sensitivity: 66.3% and 58.7%, respectively).

Conclusions: the validity and reliability of C-FCV-19S are satisfactory, and the optimal cutoff point was 17.5. The C-FCV-19S can be applied adopted in Chinese university students.
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http://dx.doi.org/10.3390/ijerph19148624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320396PMC
July 2022

Optical Flow-Aware-Based Multi-Modal Fusion Network for Violence Detection.

Entropy (Basel) 2022 Jul 6;24(7). Epub 2022 Jul 6.

Xinjiang Key Laboratory of Signal Detection and Processing, College of Information Science and Engineering, Xinjiang University, Urumqi 830046, China.

Violence detection aims to locate violent content in video frames. Improving the accuracy of violence detection is of great importance for security. However, the current methods do not make full use of the multi-modal vision and audio information, which affects the accuracy of violence detection. We found that the violence detection accuracy of different kinds of videos is related to the change of optical flow. With this in mind, we propose an optical flow-aware-based multi-modal fusion network (OAMFN) for violence detection. Specifically, we use three different fusion strategies to fully integrate multi-modal features. First, the main branch concatenates RGB features and audio features and the optical flow branch concatenates optical flow features with RGB features and audio features, respectively. Then, the cross-modal information fusion module integrates the features of different combinations and applies weights to them to capture cross-modal information in audio and video. After that, the channel attention module extracts valuable information by weighting the integration features. Furthermore, an optical flow-aware-based score fusion strategy is introduced to fuse features of different modalities from two branches. Compared with methods on the XD-Violence dataset, our multi-modal fusion network yields APs that are 83.09% and 1.4% higher than those of the state-of-the-art methods in offline detection, and 78.09% and 4.42% higher than those of the state-of-the-art methods in online detection.
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http://dx.doi.org/10.3390/e24070939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316342PMC
July 2022

Research on Chengdu Ma Goat Recognition Based on Computer Vison.

Animals (Basel) 2022 Jul 7;12(14). Epub 2022 Jul 7.

College of Information Engineering, Sichuan Agricultural University, Ya'an 625000, China.

The Chengdu ma goat is an excellent local breed in China. As one of the breeds listed in the National List of Livestock and Poultry Genetic Resources Protection, the protection of its germplasm resources is particularly important. However, the existing breeding and protection methods for them are relatively simple, due to the weak technical force and lack of intelligent means to assist. Most livestock farmers still conduct small-scale breeding in primitive ways, which is not conducive to the breeding and protection of Chengdu ma goats. In this paper, an automatic individual recognition method for Chengdu ma goats is proposed, which saves labor costs and does not depend on large-scale mechanized facilities. The main contributions of our work are as follows: (1) a new Chengdu ma goat dataset is built, which forms the basis for object detection and classification tasks; (2) an improved detection algorithm for Chengdu ma goats based on TPH-YOLOv5 is proposed, which is able to accurately localize goats in high-density scenes with severe scale variance of targets; (3) a classifier incorporating a self-supervised learning module is implemented to improve the classification performance without increasing the labeled data and inference computation overhead. Experiments show that our method is able to accurately recognize Chengdu ma goats in the actual indoor barn breeding environment, which lays the foundation for precision feeding based on sex and age.
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http://dx.doi.org/10.3390/ani12141746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312181PMC
July 2022

Genomic signature of MTOR could be an immunogenicity marker in human colorectal cancer.

BMC Cancer 2022 Jul 26;22(1):818. Epub 2022 Jul 26.

Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Background: The mTOR signaling pathway plays an important role in cancer. As a master regulator, the status of MTOR affects pathway activity and the efficacy of mTOR inhibitor therapy. However, little research has been performed to explore MTOR in colorectal cancer (CRC).

Methods: In this study, gene expression and clinical data were analyzed using The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. Signaling pathways related to MTOR in CRC were identified by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and gene set enrichment analysis (GSEA). Somatic mutation data were downloaded from TCGA and analyzed using the maftools R package. Tumor Immune Estimation Resource (TIMER) and CIBERSORT were used to analyze correlations between MTOR and tumor-infiltrating immune cells (TIICs). Finally, we detected MTOR mutations in a CRC cohort from our database using whole-exome sequencing.

Results: We found that MTOR was overexpressed in Asian CRC patients and associated with a poor prognosis. Enrichment analysis showed that MTOR was involved in metabolism, cell adhesion, and translation pathways in CRC. High MTOR expression was correlated with high tumor mutation burden (TMB) and several TIICs. Finally, we found that the mTOR signaling pathway was activated in CRC lines characterized by microsatellite instability (MSI), and the frequency of MTOR mutations was higher in MSI-high (MSI-H) patients than in microsatellite stable (MSS) patients.

Conclusions: MTOR may represent a comprehensive indicator of prognosis and immunological status in CRC. The genomic signatures of MTOR may provide guidance for exploring the role of mTOR inhibitors in CRC.
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http://dx.doi.org/10.1186/s12885-022-09901-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327395PMC
July 2022

Tracking short-term health impacts attributed to ambient PM and ozone pollution in Chinese cities: an assessment integrates daily population.

Environ Sci Pollut Res Int 2022 Jul 26. Epub 2022 Jul 26.

Center of Environmental Status and Plan Assessment, Chinese Academy of Environmental Planning, Beijing, 100012, China.

Joint and synergistic control of PM and ozone pollution is an urgent need in China and a global-widely concerned issue. Health impact assessment could provide a comprehensive perspective for PM-ozone coordinated control strategies. For a detailed understanding of the seasonality and regionality of the health impacts attributed to PM and ozone in China, this study extended the classic health impact function by daily population and assessed the short-term (daily) health impacts in 335 Chinese cities in 2021. Population migration indexes from Baidu were introduced to estimate the cities' daily population. Using this method, we quantitatively investigated the influence of population on short-term health impact assessment and identified which was significant in the Pearl River Delta (PRD) region and other populous cities. Although the annual sums of PM- and ozone-related daily health impacts were close for all Chinese cities, the PM-related health impact was equivalent to 333.96% and 32.07% of that ozone-related, during the cold and warm periods. The correlation and local spatial association analysis found significant city-specific and city-cluster associations of daily health impacts during the warm period and in Beijing-Tianjin-Hebei and surrounding regions (BTHS) and the Yangtze River Delta (YRD). Policymakers could promote period- and pollutant-targeted control actions for the major city groups, especially the BTHS, YRD, and PRD. Our methods and findings investigated the various influences of the population on short-term health impact assessment and proposed the PM-ozone collaborative control idea for key regions and city groups.
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http://dx.doi.org/10.1007/s11356-022-22067-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315092PMC
July 2022

The duration of tracheostomy dependence in patients with juvenile-onset recurrent respiratory papillomatosis.

Acta Otolaryngol 2022 Jul 25:1-6. Epub 2022 Jul 25.

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Background: Tracheostomy is a vital therapy for juvenile-onset recurrent respiratory papillomatosis (JORRP) to maintain an adequate airway in an emergency, yet the relationship between cannulation duration and prognosis has not been extensively explored.

Objectives: To investigate the predictive influence of the duration of tracheostomy dependence on JORRP remission.

Materials And Methods: A retrospective review of JORRP patients ( = 77) with tracheostomy treated in Beijing Tongren Hospital was performed.

Results: The rate of decannulation was 72.7%. After decannulation for one year, the percentage of distal spread fell from 42.9 to 30.4%. Twenty-six of 77 patients (33.8%) had remission of their disease, 40 (51.9%) continued to have active disease while 11 (14.3%) died during follow-up. The cannulation duration was positively correlated with the overall duration of this disease ( = 0.6). The cut-off point of 34.9 months for cannulation duration indicated the highest predictive value of remission. Duration of cannulation >34.9 months (OR = 0.33) and distal spread (OR = 0.29) decreased odds of remission.

Conclusion: The study demonstrates that the time span before decannulation indicates the severity of disease and cannulation aggravates the distal spread. Patients with cannulation duration ≤ 34.9 months after tracheostomy are prone to possess a relatively pleasant prognosis.
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http://dx.doi.org/10.1080/00016489.2022.2098532DOI Listing
July 2022

Detection of Carbohydrate Antigen 50 Based on a Novel Miniaturized Chemiluminescence Analyzer Enables Large-Scale Cancer Early Screening in Grassroots Community.

Front Bioeng Biotechnol 2022 7;10:920972. Epub 2022 Jul 7.

South China University of Technology, Guangzhou, China.

Early screening of cancer can effectively prolong survival time and reduce cancer mortality. However, the existing health-monitoring devices can only be carried out in professional laboratories, so large-scale early cancer screening in resource-limited settings is hardly achieved. To embrace the challenge, we developed a novel chemiluminescence immunoassay (CLIA) analyzer that does not require a professional operation. Then, it was applied to detect carbohydrate antigen 50 (CA50), a non-organ-specific tumor marker for screening various cancers. As a result, the analyzer exhibited excellent performance that the total assay time was only 15 min, and the detection limit reached 0.057 U ml. A coefficient of variance () less than 15% was well-controlled for both intra- and inter-assay precision, and the linear range was 0-500 U ml. More importantly, this analyzer can continuously detect 60 samples per hour without any professional paramedic. Finally, this analyzer has been applied to evaluate clinical samples and the detected results showed a good correlation with the clinical test results (correlation coefficient, 0.9958). These characteristics exactly meet large-scale and high-throughput early screening of cancer. Thus, this miniaturized analyzer for CA50 detection is promising to achieve early large-scale screening of cancer in the resource-limited grassroots community.
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http://dx.doi.org/10.3389/fbioe.2022.920972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302941PMC
July 2022
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