Publications by authors named "Yanbiao Wang"

12 Publications

  • Page 1 of 1

Effects of Ultrasound-Guided Bilateral Cervical Plexus Block Combined with General Anesthesia in Patients Undergoing Total Parathyroidectomy and Partial Gland Autotransplantation Surgery.

Local Reg Anesth 2021 23;14:75-83. Epub 2021 Apr 23.

Department of Orthopaedics, The 960th Hospital of the People's Liberation Army Joint Logistical Support Force, Jinan, Shandong, People's Republic of China.

Background: The aim of this study is to evaluate the effect of ultrasound-guided bilateral cervical plexus block on general anesthesia, postoperative analgesia, and surgical outcomes in patients undergoing total parathyroidectomy with autotransplantation.

Patients And Methods: Forty-eight ASA III-IV patients with hyperparathyroidism secondary to renal failure were included: 24 patients received ultrasound-guided bilateral superficial and deep cervical plexus block combined with general anesthesia (group A), and 24 patients received general anesthesia alone (group B). Postoperative patient-controlled intravenous analgesia was provided with sufentanil 2 μg/kg. The primary outcome is the postoperative pain scores. Secondary outcomes include intraoperative remifentanil dosage, changes in hemodynamics, extubation time, and sufentanil consumption. Surgical outcomes regarding calcium, phosphorus and parathormone values were also noted.

Results: The patients in group A required less remifentanil than group B (2.56±0.92mg vs 3.38±0.84mg, =0.002) and lower VAS scores at 1, 3, 10, 24, and 48h postoperatively ( < 0.001). While the systolic blood pressure in group A patients was significantly greater than that in group B at T3 (immediately after extubation, [138.33±11.36 vs 129.08±17.06 mmHg; =0.032]), heart rates in group A were lower than in group B at 1 min before induction (T1 [89.46 ± 9.14 vs 96.71±14.19, =0.042]) and 1 min after intubation (T2 [70.08 ± 5.35 vs 79.25 ± 11.81, =0.002]). The extubation time in group A was shorter than that in group B ( < 0.001). There was no difference in calcium, phosphorus and parathormone values, nor in sufentanil consumption between the groups.

Conclusion: Ultrasound-guided bilateral superficial and deep cervical plexus block combined with general anesthesia for TPTA is an effective strategy to improve anesthesia management and achieve better postoperative analgesia, and has no impact on surgical outcomes.
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http://dx.doi.org/10.2147/LRA.S299312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079358PMC
April 2021

Biomechanical analysis of a novel clavicular hook plate for the treatment of acromioclavicular joint dislocation: A finite element analysis.

Comput Biol Med 2021 Apr 14;133:104379. Epub 2021 Apr 14.

The Second Department of Orthopedics, Xi'an Centeral Hospital, No. 161, West Fifth Road, Xincheng District, Xi'an, 710003, Shaanxi, China. Electronic address:

Background: Clavicular hook plates are frequently used in clinical orthopedics to treat acromioclavicular joint dislocation. However, patients often exhibit acromial osteolysis and peri-implant fracture after hook plate fixation. To solve the above problems, we developed a novel double-hook clavicular plate and used finite element analysis (FEA) to investigate its biomechanical properties.

Methods: A finite element (FE) model was constructed and validated. Then, a double-hook clavicular plate, a single-hook clavicular plate, and an anatomical double-hook clavicular plate was implanted into the acromioclavicular joint and fixed with screws in groups 1, 2 and 3, respectively. Finally, a load was applied, and some indicators were recorded and analyzed.

Results: For both the proximal clavicular rotation angle and the distal clavicular displacement, the range of motion in groups 1 and 3 was more than 90% lower than that in group 2. The maximum von Mises stress of the clavicle in groups 1 and 3 was more than 45% lower than that in group 2. The maximum stress of the acromion in group 2 was significantly higher than that in groups 1 and 3, and that in group 3 was less than that in group 1, for both cortical and cancellous bone.

Conclusions: The double-hook clavicular plate could immediately reconstruct the stability of the acromioclavicular joint, effectively reducing the stress of the bone around the clavicle and screws. Additionally, the double-hook clavicular plate could reduce the peak stress of the acromion and produce a more uniform stress distribution.
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http://dx.doi.org/10.1016/j.compbiomed.2021.104379DOI Listing
April 2021

Abnormal expression of promotes the malignant behavior of glioma cells and leads to poor prognosis of glioma patients.

PeerJ 2021 8;9:e10820. Epub 2021 Feb 8.

Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, School of Clinical Medicine, Henan University, Zhengzhou, Henan, China.

Background: Homeobox D11 () plays an important role in a variety of cancers, but its precise role in gliomas remains unclear. This study aimed to explore the relationship between and gliomas by combining bioinformatics methods with basic experimental validation.

Materials And Methods: Obtain gene expression information and clinical information of glioma and non-tumor brain tissue samples from multiple public databases such as TCGA (666 glioma samples), CGGA (749 glioma samples), GEPIA(163 glioblastoma samples and 207 normal control samples), GEO (GSE4290 and GSE15824). Nine cases of glioma tissue and five cases of normal control brain tissue were collected from the clinical department of Henan Provincial People's Hospital for further verification. A series of bioinformatic analysis methods were used to confirm the relationship between expression and overall survival and clinical molecular characteristics of patients with glioma. RT-qPCR was used to verify the change of expression level of in glioma cells and tissues. MTT assay, colony formation assay, wound-healing assay, immunofluorescence staining, flow cytometry and western blotting were used to detect the effect of on the biological behavior of glioma cell line U251.

Results: The high expression of was significantly related to age, World Health Organization (WHO) grade, chemotherapy status, histological type, and even 1p19q codeletion data and isocitrate dehydrogenase (IDH) mutation. , as an independent risk factor, reduces the overall survival of glioma patients and has diagnostic value for the prognosis of glioma. Gene Set Enrichment Analysis (GSEA) showed that was significantly enriched in cell signaling pathway such as cell cycle, DNA replication and so on. Finally, we confirmed that the knockout of can inhibit the proliferation and invasion of U251 glioma cells, and change the biological behavior of tumor cells by preventing the progression of cell cycle.

Conclusions: may be used as a candidate biomarker for the clinical application of targeted drug and prognostic assessment treatment of glioma. In addition, This study will help to explore the pathological mechanism of glioma.
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http://dx.doi.org/10.7717/peerj.10820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877241PMC
February 2021

Biomechanical properties of a novel nonfusion artificial vertebral body for anterior lumbar vertebra resection and internal fixation.

Sci Rep 2021 Jan 29;11(1):2632. Epub 2021 Jan 29.

Department of Spine and Spinal Cord Surgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou Umiversity, Zhengzhou, 450003, China.

The aim of the study was to evaluate the biomechanical properties of a novel nonfused artificial vertebral body in treating lumbar diseases and to compare with those of the fusion artificial vertebral body. An intact finite element model of the L1-L5 lumbar spine was constructed and validated. Then, the finite element models of the fusion group and nonfusion group were constructed by replacing the L3 vertebral body and adjacent intervertebral discs with prostheses. For all finite element models, an axial preload of 500 N and another 10 N m imposed on the superior surface of L1. The range of motion and stress peaks in the adjacent discs, endplates, and facet joints were compared among the three groups. The ranges of motion of the L1-2 and L4-5 discs in flexion, extension, left lateral bending, right lateral bending, left rotation and right rotation were greater in the fusion group than those in the intact group and nonfusion group. The fusion group induced the greatest stress peaks in the adjacent discs and adjacent facet joints compared to the intact group and nonfusion group. The nonfused artificial vertebral body could better retain mobility of the surgical site after implantation (3.6°-8.7°), avoid increased mobility and stress of the adjacent discs and facet joints.
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http://dx.doi.org/10.1038/s41598-021-82086-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846776PMC
January 2021

Biomechanical Comparison of a New Memory Compression Alloy Plate versus Traditional Titanium Plate for Anterior Cervical Discectomy and Fusion: A Finite Element Analysis.

Biomed Res Int 2020 17;2020:5769293. Epub 2020 Jul 17.

Department of Spine and Spinal Cord Surgery, Henan Provincial People's Hospital, 450003, No. 7 the Weft Five Road, Zhengzhou, Henan, China.

Objective: To compare the biomechanical properties of a new memory compression alloy plate and traditional titanium plate after anterior cervical discectomy and fusion (ACDF).

Methods: A finite element model of the C3-7 segments was developed and validated. The C5-6 disc was removed, and an intervertebral cage made of peek material was implanted. Then, a new memory compression alloy plate composed of Ti-Ni memory alloy and a traditional titanium plate were integrated at the C5-6 segment. All models were subjected to a load of 73.6 N to simulate the head weight and 1 Nm of flexion-extension, lateral bending, and axial rotation. The range of segmental motion (ROM) and stress on the prostheses, adjacent discs, and endplates were analyzed.

Results: Compared with intact status, ACDF with the new prothesis and traditional titanium plate reduced the ROM of C5-6 in six directions by 95.2%-100% and increased that of adjacent discs (C4-5 and C6-7) by 4.8%-112.5%. Adjacent disc stress peaks were higher for the traditional titanium plate (0.7-4.2 MPa) than for the new prosthesis (0.6-4.1 MPa). Endplate stress peaks were the highest in ACDF with the new prosthesis (15.6-53.3 MPa), followed by ACDF with traditional titanium plate (5.0-29.4 MPa). Stress peaks were significantly lower for the new prothesis (12.8-52.3 MPa) than for the traditional titanium plate (397.0-666.1 MPa).

Conclusions: The new prosthesis improved the immediate stability of the surgical site and had an elastic modulus that was smaller than that of traditional titanium plate, making it conducive to reducing stress shielding and the impact on the adjacent intervertebral disc.
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http://dx.doi.org/10.1155/2020/5769293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382732PMC
April 2021

The effectiveness of intra-articular vs subacromial corticosteroid injection for frozen shoulder: Study protocol for a randomized controlled trial.

Medicine (Baltimore) 2020 Apr;99(16):e19706

Department of Anesthesiology, The 960th Hospital of the People's Liberation Army Joint Logistice Support Force, Shandong, China.

Background: Intra-articular (IA) corticosteroid injection is a commonly used therapy for frozen shoulder (FS), but controversy still exists regarding the injection site with the best outcome. This randomized controlled trial is designed to determine whether corticosteroid injection into the subacromial space was not inferior to IA injection in patients with FS.

Methods: This study will be a single-center, randomized, and double-blinded trial. Sixty patients who meet inclusion criteria will be randomized in a ratio of 1:1 to either subacromial injection or IA injection group. The outcome evaluations will be conducted at 4 time points (baseline, 4, 8, and 12 weeks after the injection) by an independent physical therapist. The primary outcome measure is visual analog scale for pain, whereas the secondary outcomes include Constant score, and shoulder passive range of motion including abduction, forward elevation, external rotation at the side, and internal rotation at the side.

Discussion: This study has limited inclusion and exclusion criteria and a well-controlled intervention. This clinical trial is expected to provide evidence of proper site of corticosteroid injection for the treatment of FS.

Trial Registration: This study protocol was registered in Research Registry (researchregistry5368).
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http://dx.doi.org/10.1097/MD.0000000000019706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7440081PMC
April 2020

Locking compression plate as an external fixator in the treatment of closed distal tibial fractures.

Int Orthop 2015 Nov 17;39(11):2227-37. Epub 2015 Jul 17.

Orthopaedic Department, The General Hospital of Jinan Military Command, Jinan, 250031, China.

Background: Tibial fractures often follow high-energy trauma, and although soft tissue can remain intact, poor blood supply can lead to skin necrosis, infections and potential amputation. We used closed reduction and locking compression plates as external fixators for treating closed distal tibial fractures with soft tissue compromise. The method aims to avoid those potential complications.

Methods: A retrospective series of 23 closed distal tibial fractures were treated using locking compression plates as external fixators. Protecting the blood supply was an essential intra-operative consideration, and postoperative physical therapy and partial weight bearing were encouraged early. Patients were followed at regular intervals and evaluated radiographically and clinically.

Results: The average time to radiological bony union was 29.4 weeks (range, 14-52 weeks). No infections were seen. Fractures in 22 cases (95.65 %) united, and most fractures healed in an acceptable position. All patients had good functional results and were fully weight bearing with a well-healed tibia at the final follow-up.

Conclusions: Locking compression plates can be used as external fixators and provide a high rate of union, comfortable clinical course and excellent ankle-joint motion. Although indications are limited, this method is a suitable surgical approach for treating closed distal tibial fractures with soft tissue compromise.
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http://dx.doi.org/10.1007/s00264-015-2903-7DOI Listing
November 2015

Ab initio study of structure and magnetism of late transition metal oxide TMnOm clusters (TM = Fe, Co, Ni, n = 1, 2, m = 1-6).

J Nanosci Nanotechnol 2012 Aug;12(8):6488-93

Department of Physics, Southeast University, Nanjing, 211189, P. R. China.

We systematically investigate the structural and magnetic properties of late transition metal oxide clusters, TMnOm (TM = Fe, Co, Ni; n = 1, 2; m = 1-6) by using ab initio density functional theory approach. FenOm clusters prefer to adopt three dimensional configurations, while ConOm and NinOm clusters are apt to form planar structures. The O atoms are all atomic bonding to Fe atoms in the FenOm clusters, and are partly molecularly adsorbed to Co(Ni) in ConOm(NinOm) clusters, such as Co2O(5-6) (NiO3, and Ni2O(4-6)). The average binding energies per atom of TMnOm show a monotonous increase trend with the increase of O atoms for both n = 1 and 2 for TM = Fe, Co and Ni, and reach the peak at m = 4 for TM2Om and decrease a little bit afterwards. The odd-even magnetic oscillation is major trait with the peaks at odd and bottoms at even sizes for Fe2Om and Ni2Om (m = 2-6), respectively and large magnetic moments are found in Co2O3 and Co2O6.
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http://dx.doi.org/10.1166/jnn.2012.5442DOI Listing
August 2012

Comparative ab initio study of CO adsorption on Sc(n) and Sc(n)O (n = 2-13) clusters.

J Phys Chem A 2012 Jan 22;116(1):93-7. Epub 2011 Dec 22.

Department of Physics, Southeast University, Nanjing 211189, P. R. China.

Using a cluster model, we investigated the similarities and differences in chemical activity and the magnetic properties of Sc(n) clusters (n = 2-13) and their oxides, Sc(n)O, toward CO molecule adsorption via a spin-polarized density functional theory approach. The Sc(n) and Sc(n)O clusters have similar chemical activity at small sizes of n = 2-10, whereas remarkable differences are observed at large sizes of n = 11-13. More interestingly, different magnetic responses are found in the Sc(n) and Sc(n)O clusters with the presence of CO molecule: The magnetic moment is attenuated significantly for Sc(n) with n = 2, 4, 12, and 13, whereas for Sc(n)O, it is enhanced at n = 4 and 13 and is reduced for n = 7, 8, 10, and 11. In particular, the magnetic moment remarkably increases from 7 μ(B) of Sc(13)O to 13 μ(B) of Sc(13)OCO, whereas it reduces from 19 μ(B) of Sc(13) to 5 μ(B) of Sc(13)CO.
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http://dx.doi.org/10.1021/jp208314gDOI Listing
January 2012

Comparative DFT study of structure and magnetism of TM(n)O(m) (TM = Sc-Mn, n = 1-2, m = 1-6) clusters.

Phys Chem Chem Phys 2010 Mar 19;12(10):2471-7. Epub 2010 Jan 19.

Department of Physics, Southeast University, Nanjing, 211189, PR China.

A systematic theoretical study of the structural and magnetic properties of small transition metal oxide clusters TM(n)O(m) (TM = Sc, Ti, V, Cr and Mn; n = 1, 2; m = 1-6) has been carried out by using an ab initio density functional theory approach. The O atoms are partly molecularly adsorbed in O-rich and few-valence electron TM oxide clusters like ScO(3), TiO(3), Sc(2)O(4-6), Ti(2)O(5-6), and V(2)O(6). The binding energy increases monotonously with increasing O atoms and decreases with the appearance of the peroxide unit, with the exception of ScO(3). The Sc-, Ti- and V- oxide clusters have a stronger binding than the Cr- and Mn-oxide ones. The magnetic properties are dependent on the TM element and on the density of O. The successive addition of an O atom to Mn(2) induces an odd-even magnetic oscillation from antiferromagnetic to ferrimagnetic and to nonmagnetic state. In the V-, Cr- and Mn-oxide clusters, the O atoms play a negligible role in the magnetism and they are generally antiferromagnetic when coupled with TM atoms, while the O atoms possess large magnetic moments in some Sc- and Ti- oxide clusters.
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http://dx.doi.org/10.1039/b920033aDOI Listing
March 2010

Theoretical studies on structural, magnetic, and spintronic characteristics of sandwiched Eu(n)COT(n+1) (n = 1-4) clusters.

ACS Nano 2009 Sep;3(9):2515-22

Department of Physics, Southeast University, Nanjing 211189, PR China.

Europium (Eu)-cyclootetatrene (COT = C(8)H(8)) multidecker clusters (Eu(n)COT(n+1), n = 1-4) are studied by relativistic density functional theory calculations. These clusters are found to be thermodynamically stable with freely rotatable COT rings, and their total magnetic moments (MMs) increase linearly along with the number of Eu atoms. Each Eu atom contributes about 7 mu(B) to the cluster. Meanwhile, the internal COT rings have little MM contribution while the external COT rings have about 1 mu(B) MM aligned in opposite direction to that of the Eu atoms. The total MM of the Eu(n)COT(n+1) clusters can thus be generalized as 7n - 2 mu(B) where n is the number of Eu atoms. Besides, the ground states of these clusters are ferromagnetic and energetically competitive with the antiferromagnetic states, meaning that their spin states are very unstable, especially for larger clusters. More importantly, we uncover an interesting bonding characteristic of these clusters in which the interior ionic structure is capped by two hybrid covalent-ionic terminals. We suggest that such a characteristic makes the Eu(n)COT(n+1) clusters extremely stable. Finally, we reveal that for the positively charged clusters, the hybrid covalent-ionic terminals will tip further toward the interior part of the clusters to form deeper covalent-ionic caps. In contrast, the negatively charged clusters turn to pure ionic structures.
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http://dx.doi.org/10.1021/nn900401bDOI Listing
September 2009

Ab initio study of the structure and magnetism of atomic oxygen adsorbed Scn (n = 2-14) clusters.

Phys Chem Chem Phys 2009 Jul 27;11(28):5980-5. Epub 2009 May 27.

Department of Physics, Southeast University, Nanjing, 211189, China.

We have investigated the structure and magnetism of atomic oxygen adsorbed Sc(n) (n = 2-14) clusters by using the ab initio density functional theory approach. The oxygen atom tends to attack the hollow site in the ground state structures, and the bridge site in some metastable structures. The adsorption energies exhibit clear size-dependent variation, with maxima at n = 6, 10, 12 and minima at n = 4, 7 and 13, which can be assigned to the stability of the corresponding pure Sc(n) clusters. The incoming O atom exhibits great influence on the magnetism of the clusters. The magnetic moments of the Sc(n) clusters are partly or totally quenched at n = 2, 4, 6, 10, 12, 13, and 14, and enhanced at n = 7, 9, and 11 upon the addition of O, particularly the magnetic moment increases from 1 to 5 micro(B) for n = 11 and decreases from 19 to 7 micro(B) for n = 13. The different magnetic responses to O adsorption are further investigated using the Hirshfeld population analysis and partial and local density of states analysis.
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http://dx.doi.org/10.1039/b902627dDOI Listing
July 2009