Publications by authors named "Yan Tang"

589 Publications

NMU Is a Poor Prognostic Biomarker in Patients with Lung Adenocarcinoma.

Dis Markers 2021 12;2021:5031479. Epub 2021 Jul 12.

College of Pharmacy (International Academy of Targeted Therapeutics and Innovation), National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160, China.

Lung adenocarcinoma (LUAD) is the most prevalent histologic type of lung cancer, associated with a high incidence rate and substantial mortality rate worldwide. Accumulating evidence shows that the aberrant expression of neuromedin U (NMU) contributes to the initiation and progression of cancer. Herein, we explored whether NMU could be adopted as a new diagnostic and therapeutic marker in LUAD. The UALCAN and GEPIA web resources were employed to assess data on the NMU expression in LUAD. The STRING web resource was used to develop the PPI (protein-protein interaction) network of NMU, whereas Cytoscape was applied for module analysis. The Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of NMU and the interacting proteins were examined using the WebGestalt tool. Survival analysis was performed with the Kaplan-Meier plotter tool. Results revealed that the NMU expression in LUAD was significantly higher than in the nonmalignant tissues. Moreover, higher NMU levels were dramatically related to shorter overall survival, first progression survival, and postprogression survival. The specific gene mutations G45V, R143T, and F152L of NMU occurred in LUAD samples and were associated with a worse prognosis in patients. KEGG and western blot analyses demonstrated an association of NMU with the cell cycle and the cAMP signaling cascade. Bioinformatic analysis and the in vitro experiments implicated NMU as a promising prognostic signature and treatment target for LUAD.
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http://dx.doi.org/10.1155/2021/5031479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292091PMC
July 2021

Long noncoding RNAs as biomarkers for the diagnosis of hepatocellular carcinoma: A meta-analysis.

Pathol Res Pract 2021 Jul 9;224:153546. Epub 2021 Jul 9.

Department of Clinical Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, China. Electronic address:

Background: Long non-coding RNAs (lncRNAs) are often aberrantly expressed in hepatocellular carcinoma (HCC). The role of lncRNAs in the diagnosis of HCC has attracted increasing attention. Hence, we performed a meta-analysis based on current studies to assess the diagnostic value of lncRNAs for HCC.

Methods: A systematic search was performed using PubMed, Web of Science, and Embase databases for relevant studies. The quality of the studies was assessed with the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2). A fixed-effect model was used if the value of I statistics < 50%; otherwise, a bivariate random effects model was applied (I ≥ 50%). In addition, subgroup analysis and meta-regression analysis were conducted to explore the sources of heterogeneity. Statistical analyses were based on Meta-Disc statistical software (Version 1.4) and STATA software (Version 15.1).

Results: A total of 52 studies in 20 related articles were selected for this meta-analysis, including 4930 patients and 4614 controls. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were 0.85 [95% confidence interval (CI) 0.82-0.88], 0.76 (95% CI 0.73-0.80), 3.6 (95% CI 3.1-4.2), 0.19 (95% CI 0.16-0.24), 19 (95% CI 14-26), and 0.88 (95% CI 0.85-0.91), respectively. The publication bias was evaluated by the Deek's funnel plot in our meta-analysis.

Conclusions: LncRNAs can serve as feasible HCC diagnostic biomarkers. However, further studies are necessary to confirm its diagnostic and clinical value.
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http://dx.doi.org/10.1016/j.prp.2021.153546DOI Listing
July 2021

Visual typing detection of brucellosis with a lateral flow immunoassay based on coloured latex microspheres.

J Appl Microbiol 2021 Jul 28. Epub 2021 Jul 28.

College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, 832003, P. R. China.

Aims: Treatment and preventive control strategies for Brucella melitensis (B. melitensis) and Brucella abortus (B. abortus) infection differ. A lateral flow immunoassay (LFIA) for the rapid typing and detection of brucellosis by using polychromatic dye-doped latex microspheres (LMs) as a labelling material was developed.

Methods And Results: This LFIA utilize a double-antigen sandwich method in which the BP26 protein is used as the diagnostic antigen to detect brucellosis infection and the OMP31 protein is used as the identified antigen to distinguish bovine and sheep brucellosis. Thus, people and animals infected with brucellosis can be diagnosed according to the different colours of the signals displayed on the detection lines. The results indicated that the accuracy of this assay was found to reach 98%, and the immunochromatographic test strip is highly accurate, shows good sensitivity and can facilitate typing diagnosis, among other features.

Conclusions: The established LFIA can distinguish B. melitensis infection from B. abortus infection and produces results in a short period of time while retaining the advantages of lateral flow immunoassays.

Significance And Impact Of The Study: This technology lays a foundation for the development of multi-disease test strips and the establishment of methods for rapid, multi-specimen quantitative detection and is thus of great importance for the development of medical diagnostic technologies.
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http://dx.doi.org/10.1111/jam.15240DOI Listing
July 2021

Lactate Consumption via Cascaded Enzymes Combined VEGF siRNA for Synergistic Anti-Proliferation and Anti-Angiogenesis Therapy of Tumors.

Adv Healthc Mater 2021 Jul 26:e2100799. Epub 2021 Jul 26.

Department of Pharmaceutics, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.

Lactate, as the most abundant component with concentrations of 4-40 mm in tumors, contributes to the regulation of metabolic pathways, angiogenesis, and immunosuppression, exhibiting remarkable potential in cancer treatment. Therefore, a codelivery strategy that combined the cascaded enzymes Lactate oxidase/Catalase (LOx/CAT) and vascular endothelial growth factor (VEGF) siRNA (siVEGF) to suppress tumor proliferation and angiogenesis synergistically is creatively proposed. In brief, the cationic liposomes (LIP) encapsulated with LOx/CAT and siVEGF via hydrophilic interaction and electrostatic adsorption followed by coating with PEGylated phenylboronic acid (PP) is established ([email protected][LOX+CAT]). Moreover, a simple 3-aminophenylboronic acid (PBA)-shielded strategy via fructose (Fru) is applied to further enhance the targeting efficiency in the tumor site. The obtained co-encapsulated nanoparticles (NPs) can simultaneous intracellular release of LOx/CAT and siVEGF, and the collaborative use of LOx and CAT can promote lactate consumption even under a hypoxic tumor microenvironment (TME) without producing systemic toxicity. The combined application of lactate depletion and VEGF silencing demonstrated the efficient migration suppression of 4T1 cells in vitro and superior antitumor and antimetastatic properties in vivo. This work offers a promising tumor treatment strategy via integrating cascaded enzymes and gene therapy, and explores a promising therapy regimen for 4T1 triple-negative breast cancer.
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http://dx.doi.org/10.1002/adhm.202100799DOI Listing
July 2021

The Emerging Role of Circ-SHPRH in Cancer.

Onco Targets Ther 2021 13;14:4177-4188. Epub 2021 Jul 13.

Department of Hematology and Oncology, The Second Bethune Clinical Medical College of Jilin University, Changchun, Jilin, People's Republic of China.

Purpose: Circ-SHPRH is a circular RNA that can regulate the expression of target genes by sponging microRNAs (miRNAs) or translating tumor suppressor proteins. Recent studies have suggested that circ-SHPRH may play a role in the development of tumors and cancers. Hence, this paper aimed to review the biological characteristics, molecular mechanisms, and potential clinical significance of circ-SHPRH in a variety of tumors and to evaluate its potential as a new diagnostic and prognostic biomarker.

Methods: Numerous experiments were performed regarding the abnormal expression of circ-SHPRH in a variety of tumors, including hepatocellular carcinoma, gastric carcinoma, non-small cell lung cancer, osteosarcoma, colorectal cancer, cholangiocarcinoma, pancreatic ductal adenocarcinoma, retinoblastoma, and glioblastoma.

Results: Upregulation of circ-SHPRH reportedly inhibits tumor cell proliferation, migration, and invasion, leading to the inhibition of tumor development. The clinicopathological parameters and the functional characteristics of circ-SHPRH in multiple human tumors and cancers were summarized. Circ-SHPRH functions as a tumor suppressor gene and has great potential as a diagnostic and prognostic biomarker for different types of cancer.
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http://dx.doi.org/10.2147/OTT.S317403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286153PMC
July 2021

Oxytocinergic Feedback Circuitries: An Anatomical Basis for Neuromodulation of Social Behaviors.

Front Neural Circuits 2021 14;15:688234. Epub 2021 Jun 14.

Department of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Oxytocin (OT) is a neuropeptide produced by hypothalamic neurons and is known to modulate social behavior among other functions. Several experiments have shown that OT modulates neuronal activity in many brain areas, including sensory cortices. OT neurons thus project axons to various cortical and subcortical structures and activate neuronal subpopulations to increase the signal-to-noise ratio, and in turn, increases the saliency of social stimuli. Less is known about the origin of inputs to OT neurons, but recent studies show that cells projecting to OT neurons are often located in regions where the OT receptor (OTR) is expressed. Thus, we propose the existence of reciprocal connectivity between OT neurons and extrahypothalamic OTR neurons to tune OT neuron activity depending on the behavioral context. Furthermore, the latest studies have shown that OTR-expressing neurons located in social brain regions also project to other social brain regions containing OTR-expressing neurons. We hypothesize that OTR-expressing neurons across the brain constitute a common network coordinated by OT.
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http://dx.doi.org/10.3389/fncir.2021.688234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236528PMC
June 2021

Subungual Angiokeratoma Simulating a Malignant Melanoma: A Case Report and Mini Review.

Indian J Dermatol 2021 Mar-Apr;66(2):216-218

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

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http://dx.doi.org/10.4103/ijd.IJD_141_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208257PMC
June 2021

Effects of mechanical circulatory support devices in patients with acute myocardial infarction undergoing stent implantation: a systematic review and meta-analysis of randomised controlled trials.

BMJ Open 2021 06 29;11(6):e044072. Epub 2021 Jun 29.

Department of Cardiology, Third Xiangya Hospital, Central South University, Changsha, Hunan, China

Objective: The survival benefit of using mechanical circulatory support (MCS) in patients with acute myocardial infarction (AMI) is still controversial. It is necessary to explore the impact on clinical outcomes of MCS in patients with AMI undergoing stenting.

Design: Systematic review and meta-analysis.

Data Sources: Embase, Cochrane Library, Medline, PubMed, Web of Science, ClinicalTrials.gov and Clinicaltrialsregister.eu databases were searched from database inception to February 2021.

Eligibility Criteria: Randomised clinical trials (RCTs) on MCS use in patients with AMI undergoing stent implantation were included.

Data Extraction And Synthesis: Data were extracted and summarised independently by two reviewers. Risk ratios (RRs) and 95% CIs were calculated for clinical outcomes according to random-effects model.

Results: Twelve studies of 1497 patients with AMI were included, nine studies including 1382 patients compared MCS with non-MCS, and three studies including 115 patients compared percutaneous ventricular assist devices (pVADs) versus intra-aortic balloon pump (IABP). Compared with non-MCS, MCS was not associated with short-term (within 30 days) (RR=0.90; 95% CI 0.57 to 1.41; I=46.8%) and long-term (at least 6 months) (RR=0.82; 95% CI 0.57 to 1.17; I=37.6%) mortality reductions. In the subset of patients without cardiogenic shock (CS) compared with non-MCS, the patients with IABP treatment significantly had decreased long-term mortality (RR=0.49; 95% CI 0.27 to 0.90; I=0), but without the short-term mortality reductions (RR=0.51; 95% CI 0.22 to 1.19; I=17.9%). While in the patients with CS, the patients with MCS did not benefit from the short-term (RR=1.09; 95% CI 0.67 to 1.79; I=46.6%) or long-term (RR=1.00; 95% CI 0.75 to 1.33; I=22.1%) survival. Moreover, the application of pVADs increased risk of bleeding (RR=1.86; 95% CI 1.15 to 3.00; I=15.3%) compared with IABP treatment (RR=1.86; 95% CI 1.15 to 3.00; I=15.3%).

Conclusions: In all patients with AMI undergoing stent implantation, the MCS use does not reduce all-cause mortality. Patients without CS can benefit from MCS regarding long-term survival, while patients with CS seem not.
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http://dx.doi.org/10.1136/bmjopen-2020-044072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245450PMC
June 2021

Investigation of alterations in phospholipids during the production chain of infant formulas via HILIC-QTOF-MS and multivariate data analysis.

Food Chem 2021 Jun 19;364:130414. Epub 2021 Jun 19.

College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China; Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address:

Phospholipids play a key role in infant nutrition and cognitive function. In this study, hydrophilic interaction liquid chromatography coupled to quadrupole time-of-flight mass spectrometry method was firstly developed to analyze the composition of phospholipids. Then we characterized and quantified phospholipids extracted from raw, pasteurized, homogenized, and spray-dried milk to investigate the effect of the technological process on the composition of the phospholipids. Results indicate that the composition of the phospholipids underwent minor changes after pasteurization, while the concentration of phospholipids was significantly affected by the spray-drying process, especially phosphatidylethanolamine and phosphatidylinositol. Multivariate data analysis further verified the results and indicated that phospholipids containing polyunsaturated fatty acids had undergone significant changes during the production chain, especially in spray-drying. This work reveals the changes of phospholipids composition during the production chain of infant formulas and serve as a reference for the subsequent optimization of infant formulas to meet nutritional need of infants.
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http://dx.doi.org/10.1016/j.foodchem.2021.130414DOI Listing
June 2021

A review of Cremastra appendiculata (D.Don) Makino as a traditional herbal medicine and its main components.

J Ethnopharmacol 2021 Jun 22;279:114357. Epub 2021 Jun 22.

College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. Electronic address:

Ethnopharmacological Relevance: Cremastra appendiculata (D.Don) Makino is a herbal medicine with a medicinal history of more than a thousand years in China. It is traditionally used to treat carbuncle, swelling, abscess, fistula, scrofula and scleroma (related to modern lymph node enlargement and various tumors.).

Aim Of The Review: This paper comprehensively reviewed the botany, traditional application, phytochemistry, pharmacological activities, and quality control of C. appendiculata, discussesed the application of ethnic medicine, modern scientific research and the relationship between them, and put forward some suggestions to promote the further development and utilization of C. appendiculata. We hope to provide a valuable reference for all researchers who are interested in obtaining relevant information about C. appendiculata.

Materials And Methods: The relevant information on C. appendiculata was collected through published materials and electronic databases, including ancient and modern books, Chinese Pharmacopoeia, Ph.D. and M. Sc. dissertations, PubMed, ScienceDirect, Wiley, ACS, CNKI, Springer, Taylor & Francis, Web of Science, Google Scholar, and Baidu Scholar.

Results: At present, 190 compounds have been isolated from C. appendiculata, including phenanthrene, dihydrophenanthrene, bibenzyl, flavonoids, terpenoids, glycosides, aromatics, and other compounds. These compounds have been reported to have a variety of pharmacological activities, such as anti-tumor, anti-bacterial, anti-angiogenesis, anti-oxidation, etc. Modern pharmacological studies have proved that C. appendiculata has significant anti-tumor activity and has a good therapeutic effect on liver cancer, gastric cancer, colon cancer, breast cancer, thyroid cancer and other malignant tumors.

Conclusions: C. appendiculata is not only an excellent traditional Chinese medicine for the treatment of tumors, but also a source of bioactive molecules with good application prospects. At present, the close relationship between the chemical components and pharmacological activities of C. appendiculata has not been established, and there is a lack of systematic and in-depth research on its anti-tumor components and its mechanism. In addition, it is necessary to establish systematic and effective index components and determination standards of C. appendiculata to better explore its therapeutic potential. Therefore, it is necessary to carry out further research on C. appendiculata.
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http://dx.doi.org/10.1016/j.jep.2021.114357DOI Listing
June 2021

Relationship Between Tea Drinking Behaviour and Rosacea: A Clinical Case-control Study.

Acta Derm Venereol 2021 06 30;101(6):adv00488. Epub 2021 Jun 30.

Department of Dermatology, Xiangya Hospital, Central South University, 410008 Changsha, China.

The exact mechanisms of rosacea development are unknown, but it has been suggested that tea consumption may be associated with its development. To determine the relationship between tea drinking behaviour and rosacea, this clinical case-control study recruited 2,063 participants, who completed a questionnaire about tea drinking behaviour. A 1:1 ratio propensity score matching method was used to generate 619 cases and 619 controls. High-frequency tea drinking (3 times/day: adjusted odds ratio (aOR) 2.592; 95% confidence interval (95% CI) 1.225-5.485; ≥ 4 times/day; aOR 8.86; 95% CI 3.43-22.887), non-fermented tea (aOR 2.172; 95% CI 1.562-3.022), and hot tea (aOR 2.793; 95% CI 1.796-1.344) were associated with an increased risk of rosacea. Further results showed that these tea drinking behaviours were significantly associated with an increased risk of flushing (aOR 1.41; 95% CI 1.07-1.87) and erythema (aOR 1.48; 95% CI 1.10-2.00). Tea drinking behaviour is closely related to rosacea and.
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http://dx.doi.org/10.2340/00015555-3849DOI Listing
June 2021

The effects of dynamic daylight-like light on the rhythm, cognition, and mood of irregular shift workers in closed environment.

Sci Rep 2021 Jun 22;11(1):13059. Epub 2021 Jun 22.

State Key Laboratory for Artificial Microstructure and Mesoscopic Physics, School of Physics, Peking University, 209, Chengfu Road, Haidian District, Beijing, 100871, China.

Shift workers are mostly suffered from the disruption of circadian rhythm and health problems. In this study, we designed proper light environment to maintain stable circadian rhythm, cognitive performance, and mood status of shift workers. We used five-channel light-emitting diodes to build up the dynamic daylight-like light environment. The illuminance, correlated color temperature, and circadian action factor of light were tunable in the ranges of 226 to 678 lx, 2680 to 7314 K, and 0.32 to 0.96 throughout the day (5:30 to 19:40). During the nighttime, these parameters maintained about 200 lx, 2700 K, and 0.32, respectively. In this light environment, three subjects had engaged in shift work for 38 consecutive days. We measured plasma melatonin, activity counts, continuous performance tests, and visual analogue scale on mood to assess the rhythm, cognitive performance, and mood of subjects. After 38-day shift work, the subjects' peak melatonin concentration increased significantly. Their physiological and behavioral rhythms maintained stable. Their cognitive performance improved significantly after night work, compared with that before night work. Their mood status had no significant change during the 38-day shift work. These results indicated that the light environment was beneficial to maintain circadian rhythm, cognitive performance and mood status during long-term shift work in closed environment.
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http://dx.doi.org/10.1038/s41598-021-92438-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219698PMC
June 2021

Fast structured illumination microscopy with a large dynamic measurement range.

Appl Opt 2021 Jun;60(17):5169-5176

Fast structured illumination microscopy plays an important role in micro-nano detection due to the features of high accuracy, high efficiency, and excellent adaptability. The existing method utilizes the linear region of the axial modulation response curve (AMR), and by building the relationship between the modulation and the real height, achieves topography recovery. However, the traditional method is limited to narrow dynamic measurement range due to the linear region of the AMR being very short. In this paper, a double-differential fast structured illumination microscopy (DDFSIM) is proposed. By introducing two additional detectable branches for building the double-differential axial modulation response curve (DDAMR), the proposed method can obtain a large dynamic measurement range. In the measurement, three charge-coupled devices are respectively placed in and behind and before the focal plane to generate three axial modulation response curves. Three AMRs are used to set up the DDAMR, which has a large dynamic measurement range. Through simulation and experimental verification, the measurement range of DDFSIM is twice that of the conventional method under the same system parameters.
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http://dx.doi.org/10.1364/AO.424081DOI Listing
June 2021

Willingness-to-Pay and Benefit-Cost Analysis of Botulinum Toxin for the Treatment of Rosacea in China: Findings from a Web-Based Survey.

Patient Prefer Adherence 2021 3;15:1197-1205. Epub 2021 Jun 3.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.

Purpose: Botulinum toxin (BTX) is a new treatment approach primarily aimed at relieving flushing and erythema for rosacea, but it is expensive and lacks economic benefit evaluation studies.This study aimed to investigate willingness-to-pay (WTP) of BTX treatment and conduct benefit-cost analysis (BCA) to assess if BTX treatment for rosacea is recommendable from a viewpoint of economics in China.

Methods: WTP of BTX treatment in rosacea and information of sociodemographic and clinical characteristics were inquired via an online questionnaire among the Chinese rosacea patients. The WTP was inquired by photos of three cases with different severities of rosacea before and after BTX treatment. The benefit-cost ratio (BCR) was calculated by dividing WTP by cost. Factors associated with WTP were identified using logistic regression models.

Results: The average costs of BTX treatment were USD410.09. The mean WTP for Case 1, Case 2, and Case 3 was USD295.53, 307.91, and 311.78, respectively (p<0.05 for Case 1 vs Case 3). 44.31% to 47.52% of Chinese rosacea patients were willing to pay for the BTX treatment. The BCRs were 0.72, 0.75, and 0.76 for Case 1, Case 2, and Case 3, respectively. A positive correlation between WTP and visiting frequency in the past year (OR=1.181-1.200, p=0.015-0.032, for Cases 1 and 2) or Dermatology Life Quality Index (DLQI) score (OR=2.022-2.266, all p<0.01) was observed, but duration (OR=0.521-0.564, p<0.05, for Cases 1 and 2) of rosacea was negatively correlated with WTP.

Conclusion: For rosacea patients with poor quality of life, and those with high visiting frequency, BTX should be regarded as a recommendable new treatment in China.
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http://dx.doi.org/10.2147/PPA.S311322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185460PMC
June 2021

[Design and Clinical Application of Split Memory Alloy Sternum Plate].

Zhongguo Yi Liao Qi Xie Za Zhi 2021 Jun;45(3):288-291

Lanzhou Seemine SMA Co. Ltd., Lanzhou, 730000.

Objective: The design and development of split memory alloy sternum bone plate are discussed, and the effect of split memory alloy sternum bone plate internal fixation in the treatment of sternal fractures are analysed.

Methods: The structure of the product is designed according to the anatomy and physiological characteristics of human bones, and the cross section shape of the product is designed according to the cross section shape of human bones. Internal fixation is effective in the treatment of sternal fracture.

Results: The split memory alloy sternal plate was successfully designed and developed, and all the patients with sternal fractures treated by internal fixation were clinically healed, the hospitalization and fracture healing time were significantly shortened, and no obvious complications occurred.

Conclusions: The application of split memory alloy sternal plate internal fixation in the treatment of sternal fracture has the advantages of small trauma, simple operation, safety, reliable fixation, good histocompatibility and less complications, and is conducive to promoting fracture healing and respiratory function improvement.
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http://dx.doi.org/10.3969/j.issn.1671-7104.2021.03.012DOI Listing
June 2021

Crystal Structures, Phase Stabilities, Electronic Properties, and Hardness of Yttrium Borides: New Insight from First-Principles Calculations.

J Phys Chem Lett 2021 Jun 3;12(22):5423-5429. Epub 2021 Jun 3.

Science and Technology on Surface Physics and Chemistry Laboratory, P.O. Box 9-35, Jiangyou 621908, China.

Yttrium borides have attracted much attention for their superconducting and high chemical stability. However, the fundamental knowledge of the mechanical properties and hardness of yttrium borides is rather lack. Here, we performed a systematic investigation on yttrium borides with various stoichiometries based on an unbiased CALYPSO structure search method and first-principles calculations. A new YB compound with 3 hexagonal structure is observed, which is more stable than the experimental synthesized 3̅ phase. The calculated formation enthalpy, elastic constants, and phonon dispersions distinctly show that the 3-YB is energetically, mechanically, and dynamically stable. The density of states and electronic band structure reveal that all the stable yttrium borides are metallic. Based on a semiempirical method, the Vicker hardness of 3-YB is expectant to be 37.0 GPa, indicating it is a potential ultrahard metal. Our results provide insights for future synthesis and design of new type functional materials.
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http://dx.doi.org/10.1021/acs.jpclett.1c01300DOI Listing
June 2021

Thermal Effect and Mechanism Analysis of Flame-Retardant Modified Polymer Electrolyte for Lithium-Ion Battery.

Polymers (Basel) 2021 May 21;13(11). Epub 2021 May 21.

School of Environmental and Safety Engineering, Changzhou University, Changzhou 213164, China.

In recent years, the prosperous electric vehicle industry has contributed to the rapid development of lithium-ion batteries. However, the increase in the energy density of lithium-ion batteries has also created more pressing safety concerns. The emergence of a new flame-retardant material with the additive ethoxy (pentafluoro) cyclotriphosphazene can ameliorate the performance of lithium-ion batteries while ensuring their safety. The present study proposes a new polymer composite flame-retardant electrolyte and adopts differential scanning calorimetry (DSC) and accelerating rate calorimetry to investigate its thermal effect. The study found that the heating rate is positively correlated with the onset temperature, peak temperature, and endset temperature of the endothermic peak. The flame-retardant modified polymer electrolyte for new lithium-ion batteries has better thermal stability than traditional lithium-ion battery electrolytes. Three non-isothermal methods (Kissinger; Kissinger-Akahira-Sunose; and Flynn-Wall-Ozawa) were also used to calculate the kinetic parameters based on the DSC experimental data. The apparent activation energy results of the three non-isothermal methods were averaged as 54.16 kJ/mol. The research results can provide valuable references for the selection and preparation of flame-retardant additives in lithium-ion batteries.
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http://dx.doi.org/10.3390/polym13111675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196796PMC
May 2021

Retraction Note to: Decellularized scaffolds containing hyaluronic acid and EGF for promoting the recovery of skin wounds.

J Mater Sci Mater Med 2021 May 26;32(6):62. Epub 2021 May 26.

Key Lab for Genetic Medicine of Guangdong Province, National Engineering Research Center of Genetic Medicine, Institute of Biomedicine, Jinan University, Guangzhou, 510632,, Guangdong, China.

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http://dx.doi.org/10.1007/s10856-021-06531-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154757PMC
May 2021

CircSOS2 promotes cervical squamous cell carcinoma by regulation of proliferation, cell cycle, apoptosis, migration, invasion, and glycolysis by targeting miR-543/FNDC3B axis.

Arch Biochem Biophys 2021 Sep 21;708:108925. Epub 2021 May 21.

Department of Obstetrics and Gynecology, Weihai Center Hospital, Weihai, Shandong, China. Electronic address:

Background: Cervical squamous cell carcinoma (SCC) is a common subtype of cervical cancer. Circular RNAs (circRNAs) have been demonstrated as vital regulators in gene regulation and malignant tumor progression. Therefore, the precise role of circular RNA salt overly-sensitive 2 (circSOS2) was investigated in SCC.

Methods: The relative expression levels of circSOS2, microRNA-543 (miR-543), and Fibronectin type III domain containing 3B (FNDC3B) were determined by real-time quantitative polymerase chain reaction (RT-qPCR) and Western blot assays. The correlation between percent survival times of SCC patients and circSOS2 level was presented by Kaplan-Meier Plotter analysis. The cell proliferation was measured by MTT and colony-forming assays. Flow cytometry assay was used to assess apoptosis and cell cycle distribution. The migration and invasion were measured by transwell assay. The glycolysis was analyzed by extracellular acidification rate (ECAR) assay, Glucose Assay Kit, and Lactate Assay Kit. The interaction relationship between miR-543 and circSOS2 or FNDC3B was analyzed by dual-luciferase reporter, RNA immunoprecipitation (RIP), and RNA pull-down assays. A xenograft experiment was established to clarify the functional role of circSOS2 inhibition in viv.

Results: CircSOS2 was highly expressed in SCC tissues and cells; besides, its expression level was closely associated with poor prognosis. Loss-of-functional experiments revealed that suppression of circSOS2 repressed proliferation, cell cycle process, migration, invasion, and glycolysis while induced apoptosis in SCC cells, which was overturned by inhibition of miR-543. In addition, miR-543 was downregulated and negatively correlated with circSOS2 expression in SCC tissues. We also found that overexpression of miR-543 impeded proliferation, cell cycle process, migration, invasion, and glycolysis while induced apoptosis in SCC cells by targeting FNDC3B. The silencing of circSOS2 impeded tumorigenesis in vivo.

Conclusion: CircSOS2 conferred an oncogenic function in SCC by regulation of proliferation, cell cycle, apoptosis, migration, invasion, and glycolysis of SCC cells, which was contributed to its interactions with miR-543 and FNDC3B.
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http://dx.doi.org/10.1016/j.abb.2021.108925DOI Listing
September 2021

Association of body composition with risk of overall and site-specific cancers: A population-based prospective cohort study.

Int J Cancer 2021 May 21. Epub 2021 May 21.

Center for Digestive Disease, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.

Although excess adiposity has been linked with various cancers, association between body composition and some cancers remains unclear, like lung and prostate cancers. We investigated associations of body composition with risk of overall cancer and major site-specific cancers in a prospective cohort of 454 079 cancer-free participants from UK-Biobank. Body composition was measured with bioimpedance analysis. We evaluated hazard ratio (HR) and 95% confidence interval (CI) with multivariate Cox linear and nonlinear models in men and women separately. We identified 27 794 cancers over 7.6 years of follow-up. Multivariable adjusted models including fat-free mass (FFM) and fat mass (FM) showed that FFM was positively associated with overall cancer risk in men and women (HR 1.03, 95% CI 1.01-1.04 and 1.07, 1.04-1.10, respectively); while the association between FM and overall cancer disappeared after adjusting for FFM. FFM was associated with higher risks of obesity-related cancers combined, stomach (women only), malignant melanoma, postmenopausal breast, corpus uteri, prostate, kidney (men only), and blood cancers and lower risk of lung cancer. FM was associated with higher risks of obesity-related cancers combined, esophageal, colon, lung (men only), postmenopausal breast (at the lower end of FM range), and corpus uteri cancers and lower risks of rectal, malignant melanoma (women only), prostate and blood cancers. FFM and FM seemed to have different effects on cancer risk, and the effects varied substantially by cancer type, in both direction and size. Higher FM/FFM ratio was also associated with some cancers risk, and might be a useful predictor of cancer risk.
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http://dx.doi.org/10.1002/ijc.33697DOI Listing
May 2021

Sertoli cell-derived exosome-mediated transfer of miR-145-5p inhibits Leydig cell steroidogenesis by targeting steroidogenic factor 1.

FASEB J 2021 06;35(6):e21660

Department of Cell Biology & Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, China.

In the mammalian testis, two distinct populations of Sertoli cells (SCs), the immature SCs (ISCs) and adult SCs (ASCs), play significant roles in regulating the development and function of Leydig cells. However, the effect of different SC types on the function of Leydig cells is poorly understood. Here, our study showed that miR-145-5p expression was significantly different in SCs at different stages, with the highest expression observed in ISCs. Exosomes mediate the transfer of miR-145-5p from ISCs to Leydig cells. Overexpression of miR-145-5p in Leydig cells significantly downregulated steroidogenic gene expression and inhibited testosterone synthesis. Additionally, miR-145-5p functioned by directly targeted steroidogenic factor-1 (Sf-1) and downregulated the expression of SF-1, which further downregulated the expression of steroidogenic genes, induced accumulation of lipid droplets, and eventually suppressed testosterone production. These findings demonstrate that SC-derived miR-145-5p plays a significant role in regulating the functions of Leydig cells and may therefore serve as a diagnostic biomarker for male hypogonadism developmental abnormalities during puberty.
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http://dx.doi.org/10.1096/fj.202002589RRRRDOI Listing
June 2021

Caspase-11-Gasdermin D-Mediated Pyroptosis Is Involved in the Pathogenesis of Atherosclerosis.

Front Pharmacol 2021 26;12:657486. Epub 2021 Apr 26.

Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China.

Pyroptosis is a form of cell death triggered by proinflammatory signals. Recent studies have reported that oxidized phospholipids function as caspase-11 agonists to induce noncanonical inflammasome activation in immune cells. As the levels of oxidized phospholipids derived from ox-LDL are largely elevated in atherosclerotic lesions, this study sought to determine whether oxidized lipids trigger pyroptosis and subsequent inflammation in the pathogenesis of atherosclerosis. In our current study, after integrating transcriptomic data available from the Gene Expression Omnibus with data from hyperlipidemic mice and ox-LDL-treated peritoneal macrophages, we discovered that caspase-4/11-gasdermin D-associated inflammatory signaling was significantly activated. Consistently, the mRNA expression of caspase-4 and gasdermin D was upregulated in peripheral blood mononuclear cells from patients with coronary heart disease. In particular, the expression of caspase-4 was closely associated with the severity of lesions in the coronary arteries. An study showed that caspase-11-gasdermin D activation occurred in response to a high-fat/high-cholesterol (HFHC) diet in ApoE mice, while caspase-11 deletion largely attenuated the volume and macrophage infiltration of atherosclerotic lesions. An mechanistic study showed that caspase-11-mediated inflammation occurred partly via gasdermin D-mediated pyroptosis in macrophages. Suppressing gasdermin D in HFHC-fed ApoE mice via delivery of an adeno-associated virus markedly decreased lesion volume and infiltrating macrophage numbers. Caspase-11-gasdermin D-mediated pyroptosis and the subsequent proinflammatory response in macrophages are involved in the pathogenesis of atherosclerosis. Therefore, targeting the caspase 11-gasdermin D may serve as an alternative strategy for the treatment of atherosclerosis.
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http://dx.doi.org/10.3389/fphar.2021.657486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109243PMC
April 2021

Association between Toll-like receptor gene polymorphisms and risk of Helicobacter pylori infection: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 May;100(18):e25729

Graduate School, Guangxi University of Chinese Medicine.

Background: There were many case-control studies performed the association between TLRs gene polymorphisms and the correlation of Helicobactor pylori infection, these results were inconformity. Therefore, a comprehensive meta-analysis was performed to evaluate the TLRs gene polymorphism and susceptibility to H. pylori infection.

Methods: Eligible studies were searched from PubMed, EMBASE, Web of science, Cochrane library, CNKI, CBM, Wan Fang Database and VIP Database, all the databases were searched from inception to December 2020. OR with the corresponding 95% CI were presented as associations between certain TLR gene polymorphism and the risk of H. pylori infection, all the included data will be analyzed with the software of Review Manager 5.2 and STATA 14.2.

Results: This study will provide a high-quality evidence to find the TLR gene polymorphisms with H. pylori infection susceptibility.

Conclusion: This study will explore which TLR genotype increase the risk of H. pylori infection.
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http://dx.doi.org/10.1097/MD.0000000000025729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104181PMC
May 2021

Hepatic SENP2 Controls Systemic Metabolism via SUMOylation-dependent Regulation of Liver-Adipose Tissue Crosstalk.

Hepatology 2021 May 2. Epub 2021 May 2.

Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences, Department of Endocrinology and Metabolism of Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

Background & Aims: Nonalcoholic fatty liver disease (NAFLD), characterized by aberrant triglycerides accumulation in liver, affects the metabolism remodeling of hepatic and non-hepatic tissues by secreting altered hepatokines. SUMO-specific protease 2 (SENP2) is responsible for de-SUMOylation of target protein, with broad effects on cell growth, signal transduction and developmental process. However, role of SENP2 in hepatic metabolism remains unclear.

Approach & Results: Herein, we found that SENP2 was the most dramatically increased SENPs in the fatty liver, and its level was modulated by fed/fasted conditions. To define the role of hepatic SENP2 in metabolic regulation, we generated liver-specific SENP2 knockout (Senp2-LKO) mice. Senp2-LKO mice exhibited resistance to HFD-induced hepatic steatosis and obesity. RNA-seq analysis showed that Senp2 deficiency upregulated genes involved in fatty acid oxidation and downregulated genes in lipogenesis in the liver. Additionally, ablation of hepatic SENP2 activated thermogenesis of adipose tissues. Improved energy homeostasis of both the liver and adipose tissues by SENP2 disruption prompted us to detect the hepatokines, with FGF21 identified as a key factor markedly elevated in Senp2-LKO mice that maintained metabolic homeostasis. Loss of FGF21 obviously reversed the positive effects of SENP2 deficiency on metabolism. Mechanistically, by screening transcriptional factors of FGF21, PPARα was defined as the mediator for SENP2 and FGF21. SENP2 interacted with PPARα and deSUMOylated it, thereby promoting ubiquitylation and subsequent degradation of PPARα, which in turn inhibited FGF21 expression and fatty acid oxidation. Consistently, SENP2 overexpression in liver facilitated development of metabolic disorders.

Conclusions: Our finding demonstrated key role of hepatic SENP2 in governing metabolic balance by regulating liver-adipose tissue crosstalk, linking the SUMOylation process to metabolic regulation.
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http://dx.doi.org/10.1002/hep.31881DOI Listing
May 2021

BMP4-mediated browning of perivascular adipose tissue governs an anti-inflammatory program and prevents atherosclerosis.

Redox Biol 2021 07 17;43:101979. Epub 2021 Apr 17.

Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences and Department of Endocrinology and Metabolism of Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address:

Loss of perivascular adipose tissue (PVAT) impairs endothelial function and enhances atherosclerosis. However, the roles of PVAT thermoregulation in vascular inflammation and the development of atherosclerosis remains unclear. Bone morphogenetic protein 4 (BMP4) transforms white adipocyte to beige adipocyte, while promotes a brown-to-white shift in inter-scapular brown adipose tissue (BAT). Here, we found that knockdown of BMP4 in PVAT reduced expression of brown adipocyte-characteristic genes and increased endothelial inflammation in vitro co-culture system. Ablating BMP4 expression either in adipose tissues or specifically in BAT in ApoE mice demonstrated a marked exacerbation of atherosclerotic plaque formation in vivo. We further demonstrated that proinflammatory factors (especially IL-1β) increased in the supernatant of BMP4 knockdown adipocytes. Overexpression of BMP4 in adipose tissues promotes browning of PVAT and protects against atherosclerosis in ApoE mice. These findings uncover an organ crosstalk between PVAT and blood endothelial cells that is engaged in atherosclerosis.
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http://dx.doi.org/10.1016/j.redox.2021.101979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099561PMC
July 2021

PCA062, a P-cadherin Targeting Antibody-Drug Conjugate, Displays Potent Antitumor Activity Against P-cadherin-expressing Malignancies.

Mol Cancer Ther 2021 Jul 20;20(7):1270-1282. Epub 2021 Apr 20.

Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.

The cell surface glycoprotein P-cadherin is highly expressed in a number of malignancies, including those arising in the epithelium of the bladder, breast, esophagus, lung, and upper aerodigestive system. PCA062 is a P-cadherin specific antibody-drug conjugate that utilizes the clinically validated SMCC-DM1 linker payload to mediate potent cytotoxicity in cell lines expressing high levels of P-cadherin , while displaying no specific activity in P-cadherin-negative cell lines. High cell surface P-cadherin is necessary, but not sufficient, to mediate PCA062 cytotoxicity. , PCA062 demonstrated high serum stability and a potent ability to induce mitotic arrest. In addition, PCA062 was efficacious in clinically relevant models of P-cadherin-expressing cancers, including breast, esophageal, and head and neck. Preclinical non-human primate toxicology studies demonstrated a favorable safety profile that supports clinical development. Genome-wide CRISPR screens reveal that expression of the multidrug-resistant gene ABCC1 and the lysosomal transporter SLC46A3 differentially impact tumor cell sensitivity to PCA062. The preclinical data presented here suggest that PCA062 may have clinical value for treating patients with multiple cancer types including basal-like breast cancer.
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http://dx.doi.org/10.1158/1535-7163.MCT-20-0708DOI Listing
July 2021

Adipose tissue plasticity and the pleiotropic roles of BMP signaling.

J Biol Chem 2021 Jan-Jun;296:100678. Epub 2021 Apr 17.

The Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences, and Department of Endocrinology and Metabolism of Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address:

Adipose tissues, including white, beige, and brown adipose tissue, have evolved to be highly dynamic organs. Adipose tissues undergo profound changes during development and regeneration and readily undergo remodeling to meet the demands of an everchanging metabolic landscape. The dynamics are determined by the high plasticity of adipose tissues, which contain various cell types: adipocytes, immune cells, endothelial cells, nerves, and fibroblasts. There are numerous proteins that participate in regulating the plasticity of adipose tissues. Among these, bone morphogenetic proteins (BMPs) were initially found to regulate the differentiation of adipocytes, and they are being reported to have pleiotropic functions by emerging studies. Here, in the first half of the article, we summarize the plasticity of adipocytes and macrophages, which are two groups of cells targeted by BMP signaling in adipose tissues. We then review how BMPs regulate the differentiation, death, and lipid metabolism of adipocytes. In addition, the potential role of BMPs in regulating adipose tissue macrophages is considered. Finally, the expression of BMPs in adipose tissues and their metabolic relevance are discussed.
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http://dx.doi.org/10.1016/j.jbc.2021.100678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131923PMC
April 2021

Effects of environmental contaminants in water resources on nonalcoholic fatty liver disease.

Environ Int 2021 09 12;154:106555. Epub 2021 Apr 12.

Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha 410078, China; Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, University of South China, Hengyang 421001, China; Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health Southeast University, Nanjing 210009, China. Electronic address:

The global prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing rapidly in recent years, which is now estimated to be over 25%. NAFLD is one of the most common chronic liver diseases in the world. At present, with the rapid development of economy and industrialization, many chemicals are released into the environment. These chemical contaminants in the environment might cause harm to human health and result in lipid metabolism disorder during long-term exposure. Moreover, the incentive of many NAFLD cases is unknown, and the environmental risk factors of NAFLD need to be urgently identified. Hence, we focus on the impacts of several popular environmental contaminants in water environment on the development and progression of NAFLD. These contaminants mainly include microcystins (MCs), disinfection by-products (DBPs), heavy metals (HMs), dioxins and polychlorinated biphenyls (PCBs). Through analyzing a great many epidemiological and toxicological studies, we have found positive associations between NAFLD and chronic exposure to these contaminants at the environmental levels. This review may enhance the understanding of liver damage caused by environmental pollutants, which are considered as tangible environmental risk factors for NAFLD.
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http://dx.doi.org/10.1016/j.envint.2021.106555DOI Listing
September 2021

Detrimental effects of long-term elevated serum uric acid on cognitive function in rats.

Sci Rep 2021 Mar 24;11(1):6732. Epub 2021 Mar 24.

School of Public Health, Southwest Medical University, Luzhou, 646000, China.

Uric acid is a powerful antioxidant. However, its elevated levels in association with cardiovascular diseases predispose individuals to cognitive impairment. Uric acid's effects on cognition may be related to its concentration and exposure period. We aimed to explore the effects of long-term elevated serum uric acid on cognitive function and hippocampus. Rats were randomly divided into four groups: NC, M1, M2 and M3 groups. Hyperuricemia was established in rats at week 6 and maintained until week 48 in groups M1, M2 and M3. The rats' spatial learning and memory abilities were assessed by the Morris Water Maze test at weeks 0, 6, 16, 32, and 48. After week 48, we observed pathological changes in right hippocampal CA1 and CA3 regions, and measured levels of oxidative stress, inflammatory cytokines, and β-amyloid peptide of left hippocampus. Starting from week 6, the serum uric acid level of M3 group > M2 group, the serum uric acid level of M2 group > M1 group, and the serum uric acid level of M1 group > NC group. The rats in M3 and M2 groups had longer escape latencies, longer mean distances to the platform, more extensive pathological damage, stronger inflammation response, higher oxidative stress and β-amyloid peptide levels than those in NC group. No significant differences were observed between M1 and NC groups. In addition, we also found that oxidative stress significantly correlated with tumour necrosis factor-α and β-amyloid peptide. Long-term elevated serum uric acid was significantly associated with cognitive impairment risk. Oxidative stress, tumour necrosis factor-α and β-amyloid peptide may mediate the pathogenesis of the cognitive impairment induced by uric acid. The detrimental effect of elevated serum uric acid on cognitive function was probably expressed when the serum uric acid concentration reached a certain level.
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http://dx.doi.org/10.1038/s41598-021-86279-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991666PMC
March 2021

Evolution and spatial heterogeneity patterns of ecological efficiency of resource recycling in China.

Ying Yong Sheng Tai Xue Bao 2021 Mar;32(3):983-992

School of Management, Tianjin University of Technology, Tianjin 300384, China.

Analyzing the evolution and heterogeneity patterns of resources' ecological efficiency in China could provide reference for balancing regional development and improving the ecological efficiency of resource recycling. With the panel data of resource recycling in 26 provinces (cities, regions), we measured the ecological efficiency during 2004 to 2017 by the super efficiency DEA model, and analyzed the evolution of ecological efficiency and heterogeneity patterns based on the regionalization. The results showed that, from 2004 to 2017, the ecological efficiency of resource recycling was increasing yearly, with a mean annual growth potential of 1.5%, showing an spatially increasing trend from inland to coast. The ecological efficiency in China showed significant spatial correlation, with clustering character among provinces. During 2004 to 2017, the overall correlation decreased yearly due to the strong radiation effect of high level provinces. Because of the decrease of differentiation in the north, northeast, east, central, south, southwest and northwest in China, the spatial heterogeneity of ecological efficiency of resource recycling in China turned to relieve, which was weakened by the increasing heterogeneity in the southwest region.
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http://dx.doi.org/10.13287/j.1001-9332.202103.014DOI Listing
March 2021
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