Publications by authors named "Yan Qun"

128 Publications

Issue of spatial coherence in MQW based micro-LED simulation.

Opt Express 2021 Sep;29(20):31520-31526

In existing flip-chip LED simulations, the light extraction efficiency is related to the multiple quantum well (MQW) to metal reflector distance because of optical interference. We calculate the contrast using several typical light intensity distributions among the several QWs in MQW. The coherence is obtained analytically. When the luminosity of each QW is equal, the contrast is ∼0, meaning the light is incoherent, contrary to traditional studies. The spatial coherence is important only when the light emission comes from just one QW. As the MQW has a not negligible thickness, the traditional single-dipole model is no longer accurate.
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http://dx.doi.org/10.1364/OE.438135DOI Listing
September 2021

Design and fabrication of hybrid MLAs/gratings for the enhancement of light extraction efficiency and distribution uniformity of OLEDs.

Opt Express 2021 Aug;29(16):25812-25823

Extracting light from organic light-emitting diodes (OLEDs) and improving the angular distribution are essential for their commercial applications in illumination and displays. In this work, hybrid microlens arrays (MLAs) and gratings with periods and depths in the scale of submicron have been designed and incorporated on the lighting surface of OLEDs for simultaneous enhancement of light outcoupling efficiency and angular distribution improvement. It is found that the augmentation of light extraction efficiency is mainly attributed to the MLAs, while the gratings can improve the viewing angle by increasing the angular distribution uniformity. A novel approach was proposed by combining photoresist thermal reflow, soft-lithography and plasma treatments on polydimethylsiloxane (PDMS) surfaces synergistically to realize gratings on the wavy surface of MLAs. It has been proved that with the hybrid MLAs/gratings, the external quantum efficiency (EQE) of the OLED can reach up to 22.8%, which increased by 24% compared to that of bare OLED. Moreover, the OLED with the hybrid MLAs/gratings showed an obvious lateral enhancement at wider viewing angle.
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http://dx.doi.org/10.1364/OE.427258DOI Listing
August 2021

Projection optical engine design based on tri-color LEDs and digital light processing technology.

Appl Opt 2021 Aug;60(23):6971-6977

Digital light processing (DLP) is currently a cutting-edge technology for desktop projection optical engines. Due to the passive luminescence characteristics, the DLP projection engine needs a few specific illumination optical components for light collimation, homogenization, and color combination, together with a projection lens matching the DLP chip and magnifying the image. In this paper, we propose a design approach that first splits the DLP projection optical engine into individual components for separate design, and then integrates them into a whole system for further verification. For the first step, the collimating lens group is designed for light collection, and the dichroic mirrors are used to fold the light path based on tri-color LED light sources. For the second step, a fly-eye lens and the corresponding relay lens group are designed to achieve uniform illumination on the DMD chip. The third step is to optimize the projection lens group for high-resolution projection display. Based on the design and simulation, the optical efficiency is 63.4% and the uniformity reaches 94.9% on the projection screen. The modulation transfer function (MTF) of the projection lens is higher than 0.4 at 66 lines for the distance of 500∼1500, and the distortion is lower than 1%. Simulation results show that the total luminous flux is estimated to reach 224.15 lm when the powers of tri-color LEDs are 21 W, 15.5 W, and 25 W, respectively. A projector prototype is built and tested for further verification, which provides a luminous flux of 220.43 lm and uniformity of 90.22%, respectively. The proposed design, demonstrated by both simulation and experiment, exhibits high feasibility and application potential in state-of-the-art commercial projector design.
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http://dx.doi.org/10.1364/AO.432355DOI Listing
August 2021

In situ biogas upgrading via cathodic biohydrogen using mitigated ammonia nitrogen during the anaerobic digestion of Taihu blue algae in an integrated bioelectrochemical system (BES).

Bioresour Technol 2021 Dec 8;341:125902. Epub 2021 Sep 8.

School of Environmental and Civil Engineering, Jiangnan University, Wuxi 214122, China; Jiangsu Key Laboratory of Anaerobic Biotechnology, Wuxi 214122, China; Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment, Suzhou 215011, China. Electronic address:

Biohydrogen using migrated ammonia as nitrogen source, and biogas upgrading with hydrogen collected at biocathode in an integrated bioelectrochemical system (BES) were investigated, during the anaerobic digestion of Taihu blue algae. Under an applied voltage of 0.4 V, biohydrogen (202.87 mL) reached 2.34 and 2.90 times than groups with applied voltage of 0 V and 0.8 V, respectively. Moreover, biohydrogen of the group with 1000 mg/L initial ammonia addition (524.16 mL) reached 1.53 times than that the of the control. With 0.25 bar of H injected at the beginning (R1), highest methane production (286.62) mL and content (75.73%) were obtained. Comparing to other groups, not only microbial genus responsible for both aceticlastic and hydrogenotrophic methanogens of the group R1 were apparently enriched, but key enzymes related to methane production also acquired better abundances. Therefore, it's promising to conduct the ammonia alleviating, hydrogen producing and biogas upgrading simultaneously using BES.
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http://dx.doi.org/10.1016/j.biortech.2021.125902DOI Listing
December 2021

Epstein-Barr virus EBNA2 phase separation regulates cancer-associated alternative RNA splicing patterns.

Clin Transl Med 2021 Aug;11(8):e504

Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.

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http://dx.doi.org/10.1002/ctm2.504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351520PMC
August 2021

Neck Circumference and Incidence of Type 2 Diabetes in Chinese Elderly Individuals: A Community-Based Cohort Study.

Obes Facts 2021 24;14(5):450-455. Epub 2021 Aug 24.

Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Introduction: This study aimed to investigate whether neck circumference (NC) was associated with the incidence of type 2 diabetes in Chinese elderly individuals.

Methods: A community-based cohort study was conducted on elderly inhabitants in Shanghai with a mean age of 71.0 ± 5.8 years (n = 2,646). Binary logistic regression analysis was performed to evaluate the association between NC and the prevalence of type 2 diabetes, while a Cox regression model was used to determine the association between NC and the incidence of type 2 diabetes after a follow-up of 2 years.

Results: Logistic regression analysis showed that a larger NC was significantly associated with an increased risk for type 2 diabetes in men (odds ratio [OR] 1.18, 95% confidence interval [CI] 1.07-1.31; p = 0.001) and women (OR 1.25, 95% CI 1.13-1.38; p < 0.001). Cox regression analysis revealed that NC was independently associated with the incidence of type 2 diabetes in both men (hazard ratio [HR] 1.14, 95% CI 1.05-1.23; p = 0.002) and women (HR 1.18, 95% CI 1.10-1.27; p < 0.001).

Conclusions: A larger NC was associated with a higher risk of developing type 2 diabetes in Chinese elderly individuals. However, studies with larger sample sizes and longer follow-up durations are needed to definitively determine the relationship between NC and the risk of developing type 2 diabetes.
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http://dx.doi.org/10.1159/000514219DOI Listing
August 2021

Nitrate removal from groundwater using a batch and continuous flow hybrid Fe-electrocoagulation and electrooxidation system.

J Environ Manage 2021 Nov 28;297:113387. Epub 2021 Jul 28.

Department of Chemical Engineering, University of Patras, Rio, GR-26504, Patras, Greece; Institute of Chemical Engineering Sciences (ICE-HT), Stadiou Str., Platani, GR-26504, Patras, Greece.

During the last two decades nitrate contaminated groundwater has become an extensive worldwide problem with wide-reaching negative effects on human health and the environment. In this study, a combination of electrocoagulation (EC) and electrooxidation (EO) was studied as a denitrification process to efficiently remove nitrates and ammonium (a by-product produced during EC) from real polluted groundwater. Initially, EC experiments under batch operating mode were performed using iron electrodes at different applied current density values (20-40 mA cm). Nitrate percentage removal of 100 % was recorded, however high ammonium concentrations were performed (4.5-6.5 mg NH-Ν L). Therefore, a continuous flow system was examined for the complete removal of both nitrates and EC-generated ammonium cations. The system comprised an EC reactor, a settling tank and an EO reactor. The applied current densities to the EC process were the same as those in the batch experiments, while the volumetric flow rates were 4, 6 and 8 mL min. Regarding the current density of the EO process was kept constant at the value of 75 mA cm. The percentage nitrate removal recorded during the EC process ranged between 52.0 and 100 %, while the NH-N concentration at the outlet of the EO reduced significantly (53-100 %) depending on the applied current density and the volumetric flow rate. Also, the dissolved iron concentration in the treated water was always below the legislated limit of 0.2 mg L (up to 0.027 mg L). These results indicate that the proposed hybrid system is capable of denitrifying real nitrate contaminated groundwater without generating toxic by-products, therefore making the water suitable for human consumption.
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http://dx.doi.org/10.1016/j.jenvman.2021.113387DOI Listing
November 2021

Fluorescence and crystal structure of SrLa AlO :xEu phosphor synthesized using a sol-gel method.

Luminescence 2021 Nov 11;36(7):1775-1780. Epub 2021 Aug 11.

College of Material Science and Engineering, Sichuan University, Chengdu, Sichuan, China.

The SrLa AlO :xEu phosphors were obtained using one calcination of a precursor synthesized using a sol-gel method. When excited at 396 nm, this phosphor emits a red light mixed with several strong peaks centred at 596 nm, 616 nm and 625 nm, attributed to D → F transitions of Eu ions, respectively. The concentration quenching occurs at x = 1.5 mol% mol of SrLa Eu AlO and the critical energy transfer distance is calculated to be 13.13 Å, the dipole-dipole interaction was found to play a role. In addition, the colour purity could be up to 97.5%. Simultaneously, the thermal stability of SrLaAlO :Eu was measured and the thermal quenching was found at c. 275°C (T ), the excitation energy was 0.19 eV. Current results demonstrate that SrLaAlO :Eu could be a red component candidate for white light LEDs pumped by near-UV chips.
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http://dx.doi.org/10.1002/bio.4122DOI Listing
November 2021

Microbial community and metabolic responses to electrical field intensity for alleviation of ammonia inhibition in an integrated bioelectrochemical system (BES).

Bioresour Technol 2021 Sep 27;336:125332. Epub 2021 May 27.

School of Chemical Engineering, Pusan National University, 63 Busandeahak-ro, Geumjeong-Gu, Busan 46241, Republic of Korea.

Bioelectrochemical system (BES) is a promising solution for mitigation of ammonia inhibition in anaerobic digestion (AD) process. However, the effect of electric field intensity on microbial community changes and metabolic function prediction during the alleviation of ammonia inhibition are still missing. The results of the current study represented that the improvement of ammonia removal (20.6%) and methane production (14.6%) could both be achieved at 0.2 V while higher voltages led to reductions of methane production (more than 48.9%) compared with the control. Moreover, hydrogenotrophic methanogens (Methanobacterium) seemed to be more robust to high voltages compared with aceticlastic methanogens (Methanosaeta). Additionally, bacteria for hydrolysis and acidogenesis (Rikenellaceae and Soehngenia) were found vulnerable to external electric field intensity. Furthermore, abundances changes of metabolic pathways demonstrated that the degradation of carbohydrates, lipids and proteins during all steps (hydrolysis, acidogenesis, acetogenesis and methanogenesis) of AD process could be affected by different applied voltages.
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http://dx.doi.org/10.1016/j.biortech.2021.125332DOI Listing
September 2021

Spontaneous Formation of Random Wrinkles by Atomic Layer Infiltration for Anticounterfeiting.

ACS Appl Mater Interfaces 2021 Jun 1;13(23):27548-27556. Epub 2021 Jun 1.

College of Physics and Information Engineering, Fuzhou University, Fuzhou, Fujian 350108, P. R. China.

Continuous developments of innovative anticounterfeiting strategies are vital to restrain the fast-growing counterfeit markets. Physical unclonable function (PUF)-based taggants allow for a practical solution to provide irreproducible codes for strong authentication. Herein, an advanced anticounterfeiting strategy with multiple security levels was successfully developed using screen printing and atomic layer infiltration (ALI) techniques. Macroscale poly(dimethylsiloxane) (PDMS) patterns were fabricated for primary verification. Spontaneous formation of random wrinkles with size in the micrometer scale was achieved on the top surface of screen-printed PDMS patterns due to the anisotropic relief and redistribution of extra compressive stress after AlO infiltration, which can be used for senior authentication by image identification using the artificial intelligence (AI) technique. Furthermore, the complexity and security level of a code, which are proportional to the minutia density, can be adjusted by the morphology of the wrinkles in terms of amplitude and wavelength via the degree of AlO permeation depending on ALI conditions. These spontaneously formed random wrinkles were demonstrated for validation and decoding with AI, exhibiting the merits of being unclonable, nondestructive, universally adaptable, environmentally stable, and mass-producible, and sufficiently adaptable for an industry-suitable authentication strategy.
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http://dx.doi.org/10.1021/acsami.1c04076DOI Listing
June 2021

Edge/direct-lit hybrid mini-LED backlight with U-grooved light guiding plates for local dimming.

Opt Express 2021 Apr;29(8):12179-12194

Current mini-LED backlights improve high-dynamic-range liquid crystal displays (LCDs) by using tens of thousands of direct-lit sources for local dimming. However, relative thick profile and high power consumption are the inherent limitations while compared with edge-lit backlights. By synthesizing edge- and direct-lit advantages, we propose a novel hybrid mini-LED backlight equipped with a specially designed integrated light guiding plate (LGP) for large-area displays. This LGP is seamlessly spliced by multiple physically segmented sub-LGPs with a scattering dot array on the bottom and U-shaped grooves at the corners. Each sub-LGP is a single local dimming zone that can be independently controlled. Scattering dot distribution can be numerically calculated even from multiple edge-lit sources. High optical performance and satisfactory local dimming effect are verified and analyzed via both simulation and experiment. The experimental spatial illuminance uniformity and the light extraction efficiency reach 81% and 83% while the crosstalk can be well suppressed below 0.2% between adjacent local dimming zones. The significant advantages of our design towards state-of-the-art mini-LED backlights include the zero optical distance for an ultra-thin profile, low mini-LED amount for local dimming, high optical efficiency, and infinite extension of zone number, which is expected to have a broad application prospect in the near future.
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http://dx.doi.org/10.1364/OE.421346DOI Listing
April 2021

Comparative Evaluation of Seven Tigecycline Susceptibility Testing Methods for Carbapenem-Resistant .

Infect Drug Resist 2021 20;14:1511-1516. Epub 2021 Apr 20.

Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, People's Republic of China.

Purpose: Carbapenem-resistant Enterobacteriaceae (CRE) strains are extensively resistant to most antibiotics. Tigecycline is one of the few effective drugs that can be used to treat infections caused by CRE. The aim of this study was to evaluate the accuracy of different methods for detecting the susceptibility of CRE to tigecycline.

Methods: Seven commonly used drug susceptibility testing methods were compared and evaluated for the ability to determine CRE tigecycline susceptibility: broth microdilution (BMD), agar dilution method (ADM), disk diffusion method, Etest, MicroScan, Vitek2 COMPACT, and BD Phoenix 100.

Results: The minimum inhibitory concentration (MIC) of tigecycline to inhibit 50% and 90% of CRE growth (MIC and MIC, respectively) assessed by ADM and BD Phoenix 100 was the same as that determined by the reference method, BMD. The MIC was 2 µg/mL, and the MIC was 4 µg/mL. The highest number of susceptible strains was detected by MicroScan, followed by BMD, Etest, ADM, BD Phoenix 100, Vitek2 COMPACT, and disk diffusion method, in descending order. No significant differences were observed among the tigecycline susceptibility results (P > 0.05) obtained from MicroScan, Etest, BD Phoenix 100, and BMD. BMD confirmed that 82.0% of strains were susceptible to tigecycline. ADM, MicroScan, and BD Phoenix 100 yielded the categorical agreement of 96%, 92%, and 93%, respectively. No method was found to present any very major errors (VMEs), and only the Vitek2 COMPACT yielded major errors (MEs) greater than 3%.

Conclusion: Among the seven methods tested, the ADM, MicroScan, and BD Phoenix 100 methods were accurate for determining the tigecycline susceptibility of CRE. MicroScan was acceptable with better performance than other methods.
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http://dx.doi.org/10.2147/IDR.S289499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068477PMC
April 2021

Lactoferrin is required for early B cell development in C57BL/6 mice.

J Hematol Oncol 2021 04 7;14(1):58. Epub 2021 Apr 7.

Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.

Lactoferrin (Lf) is widely distributed in mammalian milk, various tissues, and their exocrine fluids and has many physiological functions, such as bacteriostasis, antivirus, and immunoregulation. Here, we provide evidence that lactoferrin is required for early stages of B cell development in mice. Lactoferrin-deficient (Lf) C57BL/6 mice showed systematic reduction in total B cells, which was attributed to the arrest of early B cell development from pre-pro-B to pro-B stage. Although the Lf B cell "seeds" generated greater pro-B cells comparing to wild type (WT) littermates, the Lf mice bone marrow had less stromal cells, and lower CXCL12 expression, produced a less favorable "microenvironment" for early B cell development. The underlying mechanism was mediated through ERK and AKT signalings and an abnormality in the transcription factors related to early differentiation of B cells. The Lf mice also displayed abnormal antibody production in T cell-dependent and T cell-independent immunization experiments. In a pristane-induced lupus model, Lf mice had more serious symptoms than WT mice, whereas lactoferrin treatment alleviated these symptoms. This study demonstrates a novel role of lactoferrin in early B cell development, suggesting a potential benefit for using lactoferrin in B cell-related diseases.
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http://dx.doi.org/10.1186/s13045-021-01074-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8028198PMC
April 2021

The 3D-Printed Honeycomb Metamaterials Tubes with Tunable Negative Poisson's Ratio for High-Performance Static and Dynamic Mechanical Properties.

Materials (Basel) 2021 Mar 11;14(6). Epub 2021 Mar 11.

Tianjin Key Laboratory of Nonlinear Dynamics and Control, Tianjin University, Tianjin 300350, China.

The synthesized understanding of the mechanical properties of negative Poisson's ratio (NPR) convex-concave honeycomb tubes (CCHTs) under quasi-static and dynamic compression loads is of great significance for their multifunctional applications in mechanical, aerospace, aircraft, and biomedical fields. In this paper, the quasi-static and dynamic compression tests of three kinds of 3D-printed NPR convex-concave honeycomb tubes are carried out. The sinusoidal honeycomb wall with equal mass is used to replace the cell wall structure of the conventional square honeycomb tube (CSHT). The influence of geometric morphology on the elastic modulus, peak force, energy absorption, and damage mode of the tube was discussed. The experimental results show that the NPR, peak force, failure mode, and energy absorption of CCHTs can be adjusted by changing the geometric topology of the sinusoidal element. Through the reasonable design of NPR, compared with the equal mass CSHTs, CCHTs could have the comprehensive advantages of relatively high stiffness and strength, enhanced energy absorption, and damage resistance. The results of this paper are expected to be meaningful for the optimization design of tubular structures widely used in mechanical, aerospace, vehicle, biomedical engineering, etc.
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http://dx.doi.org/10.3390/ma14061353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000550PMC
March 2021

Complete mesogastric excision for locally advanced gastric cancer: short-term outcomes of a randomized clinical trial.

Cell Rep Med 2021 Mar 16;2(3):100217. Epub 2021 Mar 16.

Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

Implementation of complete mesogastric excision in gastric cancer surgery, named D2 lymphadenectomy plus complete mesogastric excision (D2+CME), has recently been proposed as an optimal procedure. However, the safety and efficacy of D2+CME remain uncertain. In this randomized controlled trial, patients receiving D2+CME exhibit less intraoperative blood loss, more lymph node harvesting, and earlier postoperative flatus than patients receiving conventional D2 radical surgery. Univariate Cox regression analysis reveals that the risk ratio for postoperative flatus in D2+CME group is 1.247 (p = 0.044). Overall postoperative complications are comparable between the two groups, but complications are significantly less severe in the D2+CME group than the D2 group (Clavien-Dindo classification grade ≥ IIIa: 4 D2+CME patients [11.8%] versus 9 D2 patients [33.3%]; p = 0.041). In conclusion, our work shows that D2+CME is associated with better short-term outcomes and surgical safety than conventional D2 dissection for patients with advanced gastric cancer.
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http://dx.doi.org/10.1016/j.xcrm.2021.100217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7974547PMC
March 2021

Simultaneous nitrogen removal and methane production from Taihu blue algae against ammonia inhibition using integrated bioelectrochemical system (BES).

Sci Total Environ 2021 Jul 28;777:146144. Epub 2021 Feb 28.

School of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China.

Simultaneous nitrogen removal and methane production using an integrated bioelectrochemical system (BES) during the anaerobic digestion (AD) process of Taihu blue algae were investigated. Upon an applied voltage of 0.4 V and total solids (TS) ratio of blue algae to anaerobic sludge as 1:1, the highest methanogenesis potential as 69.12 mL/g VS could be obtained, attaining 18.7 times of the TS ratio group of 3:1. Moreover, methane production of the integrated BES group reached 3.18 times of the AD group using conical flask, even with the same TS ratio (1:1) and initial ammonia nitrogen concentration (1000 mg NH-N/L). Apart from the bettered electrochemical performance, bio-augmented microbial genus responsible for acetoclastic methanogenesis, power generation, resisting to hostile circumstance, co-existence with hydrogenotrophic methanogens could all be enriched. Therefore, integrated BES with appropriate TS ratio under applied voltage might help offset both the ammonia and electrical stress, thereby to maintain enhanced biomethanation performance.
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http://dx.doi.org/10.1016/j.scitotenv.2021.146144DOI Listing
July 2021

Feeding strategies of continuous biomethanation processes during increasing organic loading with lipids or glucose for avoiding potential inhibition.

Bioresour Technol 2021 May 5;327:124812. Epub 2021 Feb 5.

Department of Chemical Engineering, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.

Anaerobic co-digestion is a promising solution for nutrients balance and improvement of methane production in anaerobic digestion (AD) processes. However, the knowledge about the effects of different co-substrates in manure-based AD, and different feeding strategies, on the process performance and the methanogenic microbiome pathway, are still missing. Therefore, under harsh and slow stepwise increase of organic loading rate (OLR), by addition of lipids and carbohydrates as co-substrates in continuous reactors, this study elucidated their effect on methane production and methanogenic microbiome. The results showed that, when OLR increased by adding lipids, a severe inhibition due to accumulated long-chain fatty acids (LCFA) was observed, while no significant inhibition was obtained by addition of glucose. Additionally, the LCFA inhibition in the reactor fed with lipid was alleviated by slow stepwise feeding strategy that enriched aceticlastic Methanosarcina thermophile and Methanosaeta concilii, and hydrogenotrophic Methanobacterium methanogens.
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http://dx.doi.org/10.1016/j.biortech.2021.124812DOI Listing
May 2021

In-situ pyrolysis of Taihu blue algae biomass as appealing porous carbon adsorbent for CO capture: Role of the intrinsic N.

Sci Total Environ 2021 Jun 27;771:145424. Epub 2021 Jan 27.

School of Environmental and Civil Engineering, Jiangnan University, Wuxi 214122, PR China; Jiangsu Key Laboratory of Anaerobic Biotechnology, Wuxi 214122, PR China; Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment, Suzhou 215011, PR China. Electronic address:

An environment-friendly, cost-effective, and facile N self-doping porous carbon (NC) were prepared through in-situ pyrolysis of nitrogen abundant Taihu blue algae biomass for CO uptake. It was found that the CO sorption capacity of porous carbon prepared through carbonization at 800 °C with KOH activation (N-C-800) exhibit higher CO uptake capacity of 4.88 (1 bar and 0 °C) and 2.76 mmol/g (1 bar and 25 °C) respectively, with the CO/N selectivity of N-C-800 attaining 39.3. Besides, the adsorption capacity of N-C-800 remained stable even after 7 repeated cycles, with a slight loss of nearly 6%. Moreover, total graphitic N (N) sources from the intrinsic N in N-C-800 is not only higher than other agro-sourced porous carbon materials, but the graphitic N performed a sound correlation with the CO uptake capacity. Combining experiments with Density Functional Theory (DFT) calculations, higher adsorption energy of N-C-800 (-13.6 kJ/mol, comparing with -6.9 kJ/mol of N-free carbon framework) would render the efficient adsorption of CO molecular onto the graphitic N site. The current study not only provides a new option for the reclamation of Taihu blue algae biomass as N self-doping material, but a proof-of-concept investigation employing NC materials as an appealing candidate for CO capture.
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http://dx.doi.org/10.1016/j.scitotenv.2021.145424DOI Listing
June 2021

The DDX39B/FUT3/TGFβR-I axis promotes tumor metastasis and EMT in colorectal cancer.

Cell Death Dis 2021 01 12;12(1):74. Epub 2021 Jan 12.

Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China.

DDX39B is a member of the DEAD box (DDX) RNA helicase family required for nearly all cellular RNA metabolic processes. The exact role and potential molecular mechanism of DDX39B in the progression of human colorectal cancer (CRC) remain to be investigated. In the present study, we demonstrate that DDX39B expression is higher in CRC tissues than in adjacent normal tissues. Gain- and loss-of-function assays revealed that DDX39B facilitates CRC metastasis in vivo and in vitro. Mechanistically, RNA-sequencing (RNA-seq) and RNA-binding protein immunoprecipitation-sequencing (RIP-seq) showed that DDX39B binds directly to the FUT3 pre-mRNA and upregulates FUT3 expression. Splicing experiments in vitro using a Minigene assay confirmed that DDX39B promotes FUT3 pre-mRNA splicing. A nuclear and cytoplasmic RNA separation assay indicates that DDX39B enhances the mRNA export of FUT3. Upregulation of FUT3 accelerates the fucosylation of TGFβR-I, which activates the TGFβ signaling pathway and eventually drives the epithelial-mesenchymal transition (EMT) program and contributes to CRC progression. These findings not only provide new insight into the role of DDX39B in mRNA splicing and export as well as in tumorigenesis, but also shed light on the effects of aberrant fucosylation on CRC progression.
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http://dx.doi.org/10.1038/s41419-020-03360-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803960PMC
January 2021

RNA m A methylation regulates virus-host interaction and EBNA2 expression during Epstein-Barr virus infection.

Immun Inflamm Dis 2021 06 12;9(2):351-362. Epub 2021 Jan 12.

Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.

Introduction: N -methyladenosine (m A) is the most prevalent modification that occurs in messenger RNA (mRNA), affecting mRNA splicing, translation, and stability. This modification is reversible, and its related biological functions are mediated by "writers," "erasers," and "readers." The field of viral epitranscriptomics and the role of m A modification in virus-host interaction have attracted much attention recently. When Epstein-Barr virus (EBV) infects a human B lymphocyte, it goes through three phases: the pre-latent phase, latent phase, and lytic phase. Little is known about the viral and cellular m A epitranscriptomes in EBV infection, especially in the pre-latent phase during de novo infection.

Methods: Methylated RNA immunoprecipitation sequencing (MeRIP-seq) and MeRIP-RT-qPCR were used to determine the m A-modified transcripts during de novo EBV infection. RIP assay was used to confirm the binding of EBNA2 and m A readers. Quantitative reverse-transcription polymerase chain reaction (RT-qPCR) and Western blot analysis were performed to test the effect of m A on the host and viral gene expression.

Results: Here, we provided mechanistic insights by examining the viral and cellular m A epitranscriptomes during de novo EBV infection, which is in the pre-latent phase. EBV EBNA2 and BHRF1 were highly m A-modified upon EBV infection. Knockdown of METTL3 (a "writer") decreased EBNA2 expression levels. The emergent m A modifications induced by EBV infection preferentially distributed in 3' untranslated regions of cellular transcripts, while the lost m A modifications induced by EBV infection preferentially distributed in coding sequence regions of mRNAs. EBV infection could influence the host cellular m A epitranscriptome.

Conclusions: These results reveal the critical role of m A modification in the process of de novo EBV infection.
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http://dx.doi.org/10.1002/iid3.396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127537PMC
June 2021

Tuning electron transfer by crystal facet engineering of BiVO for boosting visible-light driven photocatalytic reduction of bromate.

Sci Total Environ 2021 Mar 17;762:143086. Epub 2020 Oct 17.

Department of Water Management, Section Sanitary Engineering, Delft University of Technology, PO Box 5048, 2600, GA, Delft, the Netherlands.

Removal of bromate (BrO) has gained increasing attention in drinking water treatment process. Photocatalysis technology is an effective strategy for bromate removal. During the photocatalytic reduction of bromate process, the photo-generated electrons are reductive species toward bromate reduction and photo-generated holes responsible for water oxidation. In this study, the monoclinic bismuth vanadate (BiVO) single crystal was developed as a visible photocatalyst for the effective removal of bromate. The as-synthesized BiVO photocatalyst with optimized {010} and {110} facets ratio could achieve almost 100% removal efficiency of BrO driven by visible light with a first-order kinetic constant of 0.0368 min. As demonstrated by the electron scavenger experiment and density functional theory (DFT) calculations, the exposed facets of BiVO should account for the high photocatalytic reduction efficiency. Under visible light illumination, the photo-generated electron and holes were spatially transferred to {010} facets and {110} facets, respectively. The BiVO single crystal photocatalyst may serve as an attractive photocatalyst by virtue of its response to the visible light, spatially charge transfer and separation as well as high photocatalytic activity, which will make the removal of BrO in water much easier, more economical and more sustainable.
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http://dx.doi.org/10.1016/j.scitotenv.2020.143086DOI Listing
March 2021

CPEB3 functions as a tumor suppressor in colorectal cancer via JAK/STAT signaling.

Aging (Albany NY) 2020 11 3;12(21):21404-21422. Epub 2020 Nov 3.

Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

As RNA-binding proteins, cytoplasmic polyadenylation element binding proteins (CPEBs) have drawn increasing attention for their function of controlling gene expression related to malignant transformation via post-transcriptional regulation. However, the contribution of CPEB3 to malignant development in cancers is poorly understood. In this study, we explored the clinical, biological, and mechanical role of CPEB3 in colorectal cancer progression. We showed that colorectal cancer tissues exhibited dampened CPEB3 expression which was closely associated with poor prognosis in patients with colorectal cancer (47 vs. 62 months, = 0.035, n=99). Down-regulation CPEB3 promoted proliferation, migration, and invasion in colorectal cancer cells and vice versa. Mechanistically, CPEB3 performed as an RNA binding protein binding to 3'UTR of JAK1 mRNA to inhibit JAK/STAT pathways in colorectal cancer cells. Knockdown of CPEB3 induced active JAK-STAT signaling, thereby triggering the proliferation and metastasis capacity of colorectal cancer cells. These results suggest that CPEB3 functions as a tumor suppressor in colorectal cancer through its post-transcriptional regulation of JAK/STAT signaling. Implications: This study identified a novel role of the RNA binding protein CPEB3 in inhibiting cell proliferation and migration as well as the underlining mechanisms in colorectal cancer cells.
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http://dx.doi.org/10.18632/aging.103893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695424PMC
November 2020

All-solution-processed colour-tuneable tandem quantum-dot light-emitting diode driven by AC signal.

Nanoscale 2020 Aug;12(32):17020-17028

Department of Electrical and Computer Engineering, Sungkyunkwan University, Jangan-Gu, Suwon, Gyeonggi-do 16419, South Korea.

We demonstrate a novel structure for a quantum-dot light-emitting diode (QD-LED) with wide-range colour-tuneable pixels, fabricated via full solution processing. The proposed device has a symmetrical structure produced via stacking of an inverted-structure diode with a green QD emission layer (EML) and normal-structure diode with a red QD EML. It is an electron-only device; however, a charge generation layer in the middle of the device generates holes for the formation of excitons. Depending on the polarity of the applied voltage, either the bottom inverted unit or the top normal unit is operated, thereby emitting green or red light, respectively. The working mechanism of the device is investigated via analysis of the charge generation mechanism and carrier transport path. In addition, the colour tunability is verified using a simple alternating current (AC) driving scheme; the duty cycle modulation of the AC signal enables fine colour adjustment over a broad range, from pure green to pure red. Thus, our colour-tuneable QD-LED with vertically stacked independently operated sub-pixels can open a promising pathway towards cost-effective ultra-high-resolution displays.
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http://dx.doi.org/10.1039/d0nr03123bDOI Listing
August 2020

CTCF promotes colorectal cancer cell proliferation and chemotherapy resistance to 5-FU via the P53-Hedgehog axis.

Aging (Albany NY) 2020 07 20;12(16):16270-16293. Epub 2020 Jul 20.

Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

CTCF is overexpressed in several cancers and plays crucial roles in regulating aggressiveness, but little is known about whether CTCF drives colorectal cancer progression. Here, we identified a tumor-promoting role for CTCF in colorectal cancer. Our study demonstrated that CTCF was upregulated in colorectal cancer specimens compared with adjacent noncancerous colorectal tissues. The overexpression of CTCF promoted colorectal cancer cell proliferation and tumor growth, while the opposite effects were observed in CTCF knockdown cells. Increased GLI1, Shh, PTCH1, and PTCH2 levels were observed in CTCF-overexpressing cells using western blot analyses. CCK-8 and apoptosis assays revealed that 5-fluorouracil chemosensitivity was negatively associated with CTCF expression. Furthermore, we identified that P53 is a direct transcriptional target gene of CTCF in colorectal cancer. Western blot and nuclear extract assays showed that inhibition of P53 can counteract Hedgehog signaling pathway repression induced by CTCF knockdown. In conclusion, we uncovered a crucial role for CTCF regulation that possibly involves the P53-Hedgehog axis and highlighted the clinical utility of colorectal cancer-specific potential therapeutic target as disease progression or clinical response biomarkers.
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http://dx.doi.org/10.18632/aging.103648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485712PMC
July 2020

Large-scale microlens arrays on flexible substrate with improved numerical aperture for curved integral imaging 3D display.

Sci Rep 2020 Jul 16;10(1):11741. Epub 2020 Jul 16.

College of Physics and Information Engineering, Fuzhou University, Fuzhou, 350116, Fujian, People's Republic of China.

Curved integral imaging 3D display could provide enhanced 3D sense of immersion and wider viewing angle, and is gaining increasing interest among discerning users. In this work, large scale microlens arrays (MLAs) on flexible PMMA substrate were achieved based on screen printing method. Meanwhile, an inverted reflowing configuration as well as optimization of UV resin's viscosity and substrate's surface wettability were implemented to improved the numerical aperture (NA) of microlenses. The results showed that the NA values of MLAs could be increased effectively by adopting inverted reflowing manner with appropriate reflowing time. With decreasing the substrate's wettability, the NA values could be increased from 0.036 to 0.096, when the UV resin contact angles increased from 60.1° to 88.7°. For demonstration, the fabricated MLAs was combined to a curved 2D monitor to realize a 31-inch curved integral imaging 3D display system, exhibiting wider viewing angle than flat integral imaging 3D display system.
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http://dx.doi.org/10.1038/s41598-020-68620-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367310PMC
July 2020

Epidemiology and molecular characteristics of the type VI secretion system in Klebsiella pneumoniae isolated from bloodstream infections.

J Clin Lab Anal 2020 Nov 12;34(11):e23459. Epub 2020 Jul 12.

Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, China.

Background: The type VI secretion system (T6SS) has been identified as a novel virulence factor. This study aimed to investigate the prevalence of the T6SS genes in Klebsiella pneumoniae-induced bloodstream infections (BSIs). We also evaluated clinical and molecular characteristics of T6SS-positive K pneumoniae.

Methods: A total of 344 non-repetitive K. pneumoniae bloodstream isolates and relevant clinical data were collected from January 2016 to January 2019. For all isolates, T6SS genes, capsular serotypes, and virulence genes were detected by polymerase chain reaction, and antimicrobial susceptibility was tested by VITEK® 2 Compact. MLST was being conducted for hypervirulent K. pneumoniae (HVKP).

Results: 69 (20.1%) were identified as T6SS-positive K. pneumoniae among 344 isolates recovered from patients with BSIs. The rate of K1 capsular serotypes and ten virulence genes in T6SS-positive strains was higher than T6SS-negative strains (P = .000). The T6SS-positive rate was significantly higher than T6SS-negative rate among HVKP isolates. (P = .000). The T6SS-positive K. pneumoniae isolates were significantly more susceptible to cefoperazone-sulbactam, ampicillin-sulbactam, cefazolin, ceftriaxone, cefotan, aztreonam, ertapenem, amikacin, gentamicin, levofloxacin, and ciprofloxacin (P < 0.05). More strains isolated from the community and liver abscess were T6SS-positive K. pneumoniae (P < .05). Multivariate regression analysis indicated that community-acquired BSIs (OR 2.986), the carriage of wcaG (OR 10.579), iucA (OR 2.441), and p-rmpA (OR 7.438) virulence genes, and biliary diseases (OR 5.361) were independent risk factors for T6SS-positive K. pneumoniae-induced BSIs.

Conclusion: The T6SS-positive K. pneumoniae was prevalent in individuals with BSIs. T6SS-positive K. pneumoniae strains seemed to be hypervirulent which revealed the potential pathogenicity of this emerging gene cluster.
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http://dx.doi.org/10.1002/jcla.23459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676210PMC
November 2020

CPEB3 inhibits epithelial-mesenchymal transition by disrupting the crosstalk between colorectal cancer cells and tumor-associated macrophages via IL-6R/STAT3 signaling.

J Exp Clin Cancer Res 2020 Jul 11;39(1):132. Epub 2020 Jul 11.

Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, 1838th North Guangzhou Avenue, Guangzhou, 510515, China.

Background: Crosstalk between cancer cells and tumor-associated macrophages (TAMs) mediates tumor progression in colorectal cancer (CRC). Cytoplasmic polyadenylation element binding protein 3 (CPEB3) has been shown to exhibit tumor-suppressive role in CRC.

Methods: The expression of CPEB3, CD68, CD86 and CD163 was determined in CRC tissues. SW480 or HCT116 cells overexpressing CPEB3 and LoVo or RKO cells with CPEB3 knockdown were constructed. Stably transfected CRC cells were co-cultured with THP-1 macrophages to determine the malignant phenotype of CRC cells, macrophage polarization, and secretory signals. The inhibition of CPEB3 on tumor progression and M2-like TAM polarization was confirmed in nude mice.

Results: Decreased CPEB3 expression in CRC was associated with fewer CD86 TAMs and more CD163 TAMs. CPEB3 knockdown in CRC cells increased the number of CD163 TAMs and the expression of IL1RA, IL-6, IL-4 and IL-10 in TAM supernatants. TAMs enhanced CRC cell proliferation and invasion via IL-6, and then activated the IL-6R/STAT3 pathway in CRC cells. However, CPEB3 reduced the IL-6R protein levels by directly binding to IL-6R mRNA, leading to decreased phosphorylated-STAT3 expression in CRC cells. CCL2 was significantly increased in CPEB3 knockdown cells, while CCL2 antibody treatment rescued the effect of CPEB3 knockdown in promoting CD163 TAM polarization. Eventually, we confirmed that CPEB3 inhibits tumor progression and M2-like TAM polarization in vivo.

Conclusions: CPEB3 is involved in the crosstalk between CRC cells and TAMs by targeting IL-6R/STAT3 signaling.
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http://dx.doi.org/10.1186/s13046-020-01637-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353816PMC
July 2020

IMP-38-Producing High-Risk Sequence Type 307 Klebsiella pneumoniae Strains from a Neonatal Unit in China.

mSphere 2020 07 1;5(4). Epub 2020 Jul 1.

Department of Clinical Laboratory, Xiangya Hospital of Central South University, Changsha, China

An emerging multidrug-resistant high-risk clone of sequence type 307 (ST307) has been increasingly reported worldwide. Here, we described the genomic characteristics of an IMP-38-producing ST307 strain and investigated the prevalence of among carbapenem-resistant isolates from a tertiary care hospital in central China. A total of 14 IMP-38-producing ST307 strains were identified from 2013 to 2016, with 13 strains isolated from patients with neonatal sepsis in the neonatal ward. PacBio and Illumina whole-genome sequencing analysis performed on a representative IMP-38-producing strain, WCGKP294, showed that it contained a circular chromosome and two plasmids. Carbapenemase gene is colocated with in transposon Tn on an IncHI5 plasmid (pWCGKP294-2). WCGKP294 harbors another IncFIB plasmid, pWCGKP294-1, carrying three copies of tandem-repeated IS- -----IS composite transposon elements. Phylogenetic analysis placed WCGKP294 in the global ST307 cluster, distant from the U.S. (Texas) and South Africa clusters. Nevertheless, WCGKP294 does not contain the chromosomal fluoroquinolone resistance-associated mutations and IncFIIK/IncFIBK plasmid-associated gene that are frequently found in other global ST307 strains. We described the genome and resistome characterization of a carbapenem-resistant ST307 strain carrying in China. This report highlights that the high-risk ST307 clone continues to acquire different antimicrobial resistance genes, posing significant challenges to clinical practice, and should be closely monitored.
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http://dx.doi.org/10.1128/mSphere.00407-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333572PMC
July 2020

Risk Factors for Subsequential Carbapenem-Resistant Clinical Infection Among Rectal Carriers with Carbapenem-Resistant .

Infect Drug Resist 2020 5;13:1299-1305. Epub 2020 May 5.

Department of Clinical Laboratory, Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.

Purpose: Carbapenem-resistant (CRKP) infection has become a critical clinical concern for its high mortality. Rectal carriage of CRKP has been reported playing an important role in CRKP infection; however, the extent to which carrier develops clinical CRKP infection is unclear. This study aimed to identify risk factors for developing subsequential CRKP clinical infection in rectal carriers with CRKP.

Patients And Methods: Patients were screened for rectal carriage of CRKP in a tertiary university hospital; then, rectal CRKP carriers were divided into case group (those who developed subsequential clinical infection) and control group. Demographics, comorbid conditions, invasive procedures, antimicrobial exposure and other clinical parameters of those two groups were compared and analyzed using univariate and multivariate logistic regression analyses. Antimicrobial susceptibility profile and carbapenemase phenotype/genotype of those CRKP isolates were determined. MLST was applied to elucidate the molecular epidemiology of rectal CRKP isolates and clinical infection ones.

Results: Eight hundred and thirty-five patients were screened for rectal CRKP carriage. A total of 62 CRKP rectal carriers were identified; among them, 37.1% (23/62) developed CRKP clinical infection. CRKP isolates were resistant to most of the tested antimicrobial agents. ST11 was the dominant MLST type in rectal CRKP isolates (71.0%), and all the 23 clinical infection isolates were ST11. Multivariate analysis revealed that admission to the intensive care unit (ICU) (OR, 6.753; =0.006), being in coma condition (OR, 11.085; =0.015) and receiving central venous catheter (OR, 8.628; =0.003) were independent risk factors for progressing to subsequential CRKP infection among those rectal carriers.

Conclusion: This study identified independent risk factors for developing subsequential CRKP clinical infection among CRKP rectal carriers, with being in coma condition as a new finding. It would help clinician target those high-risk rectal CRKP-colonized patients for prevention of subsequential clinical infection.
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http://dx.doi.org/10.2147/IDR.S247101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211322PMC
May 2020

A retrospective study on Escherichia coli bacteremia in immunocompromised patients: Microbiological features, clinical characteristics, and risk factors for shock and death.

J Clin Lab Anal 2020 Aug 8;34(8):e23319. Epub 2020 Apr 8.

Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, China.

Background: To evaluate clinical features, bacterial characteristics, and risk factors for shock and mortality of immunocompromised patients with Escherichia coli bacteremia.

Methods: A nearly 6-year retrospective study of E coli bacteremia in 188 immunocompromised patients at Xiangya Hospital was conducted. Demographic, clinical, and laboratory data were documented. Phylogenetic background and virulence factors of E coli isolates were detected by polymerase chain reaction. Risk factors for shock and mortality were also investigated.

Results: Of all 188 E coli isolates, most prevalent virulence factors were fimH (91.0%), followed by traT (68.6%) and iutA (67.0%), while papG allele I, gafD, and cdtB were not detected. Phylogenetic group D was dominant (42.0%) among all isolates, and group B2 accounted for 17.6%, while group A and B1 accounted for 28.2% and 12.2%, respectively. In univariate analysis, ibeA and cnf1 were associated with mortality, which were not found in multivariate regression analysis. 22.3% of patients suffered shock, and 30-day mortality rate was 21.3%. MDR (HR 2.956; 95% CI, 1.091-8.012) was the only risk factor for shock, while adult (HR 0.239; 95% CI, 0.108-0.527) was a protective factor. Multivariate analysis revealed that shock (HR 4.268; 95% CI, 2.208-8.248; P < .001) and Charlson index > 2 (HR 2.073; 95% CI, 1.087-3.952; P = .027) were associated with fatal outcome.

Conclusions: Escherichia coli bacteremia was highly lethal in immunocompromised patients, and host-related factors played major roles in poor prognosis, while bacterial determinants had little effect on outcome. This study also provided additional information about the virulence and phylogenetic group characteristics of E coli bacteremia.
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http://dx.doi.org/10.1002/jcla.23319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439330PMC
August 2020
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